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    John Lin

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0647
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Structure guided design of photoselectable channelrhodopsins
      NIH/NEI R21EY027620Sep 30, 2016 - Jul 31, 2018
      Role: Co-Principal Investigator
      Optogenetic mapping of synaptic activity and control of intracellular signaling
      NIH/NINDS U01NS090590Sep 30, 2014 - Jul 31, 2017
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sengupta A, Chaffiol A, Macé E, Caplette R, Desrosiers M, Lampic M, Forster V, Marre O, Lin J, Sahel JA, Picaud S, Dalkara D, Duebel J. Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina. EMBO Mol Med. 2016 11; 8(11):1248-1264. PMID: 27679671.
        View in: PubMed
      2. Rodriguez EA, Campbell RE, Lin J, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. Trends Biochem Sci. 2017 Feb; 42(2):111-129. PMID: 27814948.
        View in: PubMed
      3. Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin J, Tsien RY. A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein. Nat Methods. 2016 Sep; 13(9):763-9. PMID: 27479328; PMCID: PMC5007177 [Available on 03/01/17].
      4. Hooks BM, Lin J, Guo C, Svoboda K. Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex. J Neurosci. 2015 Mar 11; 35(10):4418-26. PMID: 25762684; PMCID: PMC4355205.
      5. Nabavi S, Fox R, Proulx CD, Lin J, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. 2014 Jul 17; 511(7509):348-52. PMID: 24896183; PMCID: PMC4210354.
      6. Levin RA, Felsen CN, Yang J, Lin J, Whitney MA, Nguyen QT, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415. PMID: 24816650; PMCID: PMC4016317.
      7. Inagaki HK, Jung Y, Hoopfer ED, Wong AM, Mishra N, Lin J, Tsien RY, Anderson DJ. Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship. Nat Methods. 2014 Mar; 11(3):325-32. PMID: 24363022; PMCID: PMC4151318.
      8. Lin J, Knutsen PM, Muller A, Kleinfeld D, Tsien RY. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nat Neurosci. 2013 Oct; 16(10):1499-508. PMID: 23995068; PMCID: PMC3793847.
      9. Lin J, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 2013 Jul 24; 79(2):241-53. PMID: 23889931; PMCID: PMC3804158.
      10. Lin J. Production and validation of recombinant adeno-associated virus for channelrhodopsin expression in neurons. Methods Mol Biol. 2013; 998:401-15. PMID: 23529447.
        View in: PubMed
      11. Miller EW, Lin J, Frady EP, Steinbach PA, Kristan WB, Tsien RY. Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2114-9. PMID: 22308458; PMCID: PMC3277584.
      12. Lin J. Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants. Prog Brain Res. 2012; 196:29-47. PMID: 22341319.
        View in: PubMed
      13. Lin J. A user's guide to channelrhodopsin variants: features, limitations and future developments. Exp Physiol. 2011 Jan; 96(1):19-25. PMID: 20621963; PMCID: PMC2995811.
      14. Lin J, Lin MZ, Steinbach P, Tsien RY. Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys J. 2009 Mar 04; 96(5):1803-14. PMID: 19254539; PMCID: PMC2717302.
      15. Sheng G, Chang GQ, Lin J, Yu ZX, Fang ZH, Rong J, Lipton SA, Li SH, Tong G, Leibowitz SF, Li XJ. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med. 2006 May; 12(5):526-33. PMID: 16604089.
        View in: PubMed
      16. Lin J, Chung KK, de Castro D, Funk GD, Lipski J. Effects of muscarinic acetylcholine receptor activation on membrane currents and intracellular messengers in medium spiny neurones of the rat striatum. Eur J Neurosci. 2004 Sep; 20(5):1219-30. PMID: 15341594.
        View in: PubMed
      17. Lin J, van Wyk M, Bowala TK, Teo MY, Lipski J. Dendritic projections and dye-coupling in dopaminergic neurons of the substantia nigra examined in horizontal brain slices from young rats. J Neurophysiol. 2003 Oct; 90(4):2531-5. PMID: 12815027.
        View in: PubMed
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