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John Lin

TitleAssistant Project Scientist
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0647
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Structure guided design of photoselectable channelrhodopsins
    NIH/NEI R21EY027620Sep 30, 2016 - Jul 31, 2018
    Role: Co-Principal Investigator
    Optogenetic mapping of synaptic activity and control of intracellular signaling
    NIH/NINDS U01NS090590Sep 30, 2014 - Jul 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Rodriguez EA, Campbell RE, Lin J, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. Trends Biochem Sci. 2017 02; 42(2):111-129. PMID: 27814948.
      View in: PubMed
    2. Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin J, Tsien RY. A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein. Nat Methods. 2016 09; 13(9):763-9. PMID: 27479328; PMCID: PMC5007177 [Available on 03/01/17].
    3. Nabavi S, Fox R, Proulx CD, Lin J, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. 2014 Jul 17; 511(7509):348-52. PMID: 24896183; PMCID: PMC4210354.
    4. Levin RA, Felsen CN, Yang J, Lin J, Whitney MA, Nguyen QT, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415. PMID: 24816650; PMCID: PMC4016317.
    5. Inagaki HK, Jung Y, Hoopfer ED, Wong AM, Mishra N, Lin J, Tsien RY, Anderson DJ. Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship. Nat Methods. 2014 Mar; 11(3):325-32. PMID: 24363022; PMCID: PMC4151318.
    6. Lin J, Knutsen PM, Muller A, Kleinfeld D, Tsien RY. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nat Neurosci. 2013 Oct; 16(10):1499-508. PMID: 23995068; PMCID: PMC3793847.
    7. Lin J, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 2013 Jul 24; 79(2):241-53. PMID: 23889931; PMCID: PMC3804158.
    8. Lin J. Production and validation of recombinant adeno-associated virus for channelrhodopsin expression in neurons. Methods Mol Biol. 2013; 998:401-15. PMID: 23529447.
      View in: PubMed
    9. Miller EW, Lin J, Frady EP, Steinbach PA, Kristan WB, Tsien RY. Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2114-9. PMID: 22308458; PMCID: PMC3277584.
    10. Lin J. Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants. Prog Brain Res. 2012; 196:29-47. PMID: 22341319.
      View in: PubMed
    11. Lin J. A user's guide to channelrhodopsin variants: features, limitations and future developments. Exp Physiol. 2011 Jan; 96(1):19-25. PMID: 20621963; PMCID: PMC2995811.
    12. Lin J, Lin MZ, Steinbach P, Tsien RY. Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys J. 2009 Mar 04; 96(5):1803-14. PMID: 19254539; PMCID: PMC2717302.