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John Griffin

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0912
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Protein C Pathways
    NIH/NHLBI R01HL142975Jun 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
    NIH/NIAID U01AI133561Jun 5, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Human exomics genotyping-driven discovery and characterization of proteins related to clinical thrombosis, blood coagulation and thrombin generation
    NIH/NHLBI R01HL133728Sep 15, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Murine Protein C and Protein S Proof of Principle Research
    NIH/NHLBI R01HL104074Jan 1, 2011 - Jul 31, 2011
    Role: Principal Investigator
    Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    NIH/NHLBI RC1HL101034Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Drug Engineering of Transglutaminase 2 Inhibitors
    NIH/NIDDK R41DK081244Feb 1, 2009 - Jan 31, 2011
    Role: Principal Investigator
    Novel targets and agents to treat thrombotic disorders
    NIH/NHLBI R01HL078684Sep 24, 2004 - Aug 31, 2005
    Role: Principal Investigator
    Structure and Function of Protein C
    NIH/NHLBI R01HL052246Dec 1, 1994 - Dec 31, 2017
    Role: Principal Investigator
    STRUCTURE AND FUNCTION OF PROTEIN C
    NIH/NHLBI R37HL052246Dec 1, 1994 - Dec 26, 2004
    Role: Principal Investigator
    IMPROVED FUNCTIONS FOR RECEPTOR LIKE ANTIBIOTICS
    NIH/NIGMS R01GM051122May 1, 1994 - Aug 31, 1998
    Role: Principal Investigator
    NOVEL SEMISYNTHETIC DERIVATIVES OF VANCOMYCIN
    NIH/NIGMS R21GM051122May 1, 1994 - Apr 30, 1996
    Role: Principal Investigator
    Thrombus Formation and Antithrombotic Intervention
    NIH/NHLBI P01HL031950Apr 1, 1984 - Jun 30, 2016
    Role: Principal Investigator
    PROTEIN C--AN ANTITHROMBOTIC-PROFIBRINOLYTIC AGENT
    NIH/NHLBI R01HL024891Aug 1, 1982 - Jul 31, 1992
    Role: Principal Investigator
    Proteins of Coagulation Pathways
    NIH/NHLBI R01HL021544Jul 1, 1977 - Aug 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Griffin J, Zlokovic BV, Mosnier LO. Activated protein C, protease activated receptor 1 and neuroprotection. Blood. 2018 Jun 04. PMID: 29866816.
      View in: PubMed
    2. Healy LD, Rigg RA, Griffin J, McCarty OJT. Regulation of immune cell signaling by activated protein C. J Leukoc Biol. 2018 Mar 30. PMID: 29601101.
      View in: PubMed
    3. Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin J, Nizet V, Corriden R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 Mar 05. PMID: 29514266.
      View in: PubMed
    4. Martos L, Ramón LA, Oto J, Fernández-Pardo Á, Bonanad S, Cid AR, Gruber A, Griffin J, España F, Navarro S, Medina P. a2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:a2M Levels Are Associated with Venous Thromboembolism. Thromb Haemost. 2018 Apr; 118(4):630-638. PMID: 29448296.
      View in: PubMed
    5. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin J. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 Feb 02. PMID: 29396891.
      View in: PubMed
    6. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin J. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 Mar 15; 131(11):1163-1171. PMID: 29343482.
      View in: PubMed
    7. Prince R, Bologna L, Manetti M, Melchiorre D, Rosa I, Dewarrat N, Suardi S, Amini P, Fernández JA, Burnier L, Quarroz C, Reina Caro MD, Matsumura Y, Kremer Hovinga JA, Griffin J, Simon HU, Ibba-Manneschi L, Saller F, Calzavarini S, Angelillo-Scherrer A. Targeting anticoagulant protein S to improve hemostasis in hemophilia. Blood. 2018 Mar 22; 131(12):1360-1371. PMID: 29317453.
      View in: PubMed
    8. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin J, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2017 Sep 18. PMID: 28923278.
      View in: PubMed
    9. Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin J, Isermann B, Shahzad K. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. Blood. 2017 12 14; 130(24):2664-2677. PMID: 28882883.
      View in: PubMed
    10. Fernández JA, Xu X, Sinha RK, Mosnier LO, Sanner MF, Griffin J. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S. Blood Adv. 2017 Aug 08; 1(18):1423-1426. PMID: 29296783.
      View in: PubMed
    11. Deguchi H, Navarro S, Payne AB, Elias DJ, Dowling NF, Austin HD, España F, Medina P, Hooper WC, Griffin J. Low level of the plasma sphingolipid, glucosylceramide, is associated with thrombotic diseases. Res Pract Thromb Haemost. 2017 Jul; 1(1):33-40. PMID: 29202121.
      View in: PubMed
    12. Deguchi H, Elias DJ, Griffin J. Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk. Res Pract Thromb Haemost. 2017 Jul; 1(1):93-102. PMID: 29082360.
      View in: PubMed
    13. Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin J, McCarty OJT. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017 05 26; 292(21):8616-8629. PMID: 28408624.
      View in: PubMed
    14. Griffin J, Mosnier LO, Fernández JA, Zlokovic BV. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 Nov; 36(11):2143-2151. PMID: 27758767.
      View in: PubMed
    15. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin J, Goldman SA, Zlokovic BV. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5. PMID: 27548576.
      View in: PubMed
    16. Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJT, Cohen MJ, Griffin J. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood. 2016 10 06; 128(14):1870-1878. PMID: 27421960.
      View in: PubMed
    17. Burnier L, Boroujerdi A, Fernández JA, Welser-Alves JV, Griffin J, Milner R. Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C. Exp Neurol. 2016 09; 283(Pt A):396-403. PMID: 27412766.
      View in: PubMed
    18. Deguchi H, Banerjee Y, Elias DJ, Griffin J. Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism. J Atheroscler Thromb. 2016 Oct 01; 23(10):1159-1167. PMID: 27169917.
      View in: PubMed
    19. Griffin J, Fernández JA, Lyden PD, Zlokovic BV. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thromb Res. 2016 May; 141 Suppl 2:S62-4. PMID: 27207428; PMCID: PMC4904825 [Available on 05/01/17].
    20. Alsultan A, Gale AJ, Kurban K, Khalifah M, Albadr FB, Griffin J. Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis. Thromb Res. 2016 Jul; 143:17-21. PMID: 27172833; PMCID: PMC4943460 [Available on 07/01/17].
    21. Gale AJ, Bhat V, Pellequer JL, Griffin J, Mosnier LO, Von Drygalski A. Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding. Pharm Res. 2016 06; 33(6):1517-26. PMID: 26960296; PMCID: PMC4854778 [Available on 06/01/17].
    22. Sinha RK, Yang XV, Fernández JA, Xu X, Mosnier LO, Griffin J. Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):518-24. PMID: 26800564; PMCID: PMC4816599 [Available on 03/01/17].
    23. Bhat V, von Drygalski A, Gale AJ, Griffin J, Mosnier LO. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thromb Haemost. 2016 Mar; 115(3):551-61. PMID: 26466980; PMCID: PMC4775351 [Available on 02/28/17].
    24. Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin J, Weiler H. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood. 2015 Nov 19; 126(21):2415-23. PMID: 26341257; PMCID: PMC4653768 [Available on 11/19/16].
    25. Amar AP, Griffin J, Zlokovic BV. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344. PMID: 26388732; PMCID: PMC4556986.
    26. Yegneswaran S, Banerjee Y, Fernández JA, Deguchi H, Griffin J. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex. PLoS One. 2015; 10(8):e0135025. PMID: 26263376; PMCID: PMC4532512.
    27. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin J, Miyata T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015 Nov 05; 126(19):2247-53. PMID: 26251307; PMCID: PMC4635119 [Available on 11/05/16].
    28. Deguchi H, Wolfbauer G, Cheung MC, Banerjee Y, Elias DJ, Fernández JA, Albers JJ, Griffin J. Inhibition of thrombin generation in human plasma by phospholipid transfer protein. Thromb J. 2015; 13:24. PMID: 26185485; PMCID: PMC4504036.
    29. Deguchi H, Banerjee Y, Trauger S, Siuzdak G, Kalisiak E, Fernández JA, Hoang L, Tran M, Yegneswaran S, Elias DJ, Griffin J. Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data. Blood. 2015 Sep 24; 126(13):1595-600. PMID: 26175037; PMCID: PMC4582336.
    30. Griffin J, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 2015 May 07; 125(19):2898-907. PMID: 25824691; PMCID: PMC4424414.
    31. Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin J, Ruf W, Weiler H. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30; 125(18):2845-54. PMID: 25733582; PMCID: PMC4424632.
    32. Fernandez JA, Deguchi H, Banka CL, Witztum JL, Griffin J. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):570-2. PMID: 25550205; PMCID: PMC4344393.
    33. Mosnier LO, Zlokovic BV, Griffin J. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost. 2014 Nov; 112(5):883-92. PMID: 25230930; PMCID: PMC4356129.
    34. von Drygalski A, Bhat V, Gale AJ, Burnier L, Cramer TJ, Griffin J, Mosnier LO. An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C. PLoS One. 2014; 9(8):e104304. PMID: 25127130; PMCID: PMC4134195.
    35. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin J, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. PMID: 24591593.
      View in: PubMed
    36. Deguchi H, Elias DJ, Trauger S, Zhang HM, Kalisiak E, Siuzdak G, Griffin J. Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids. Br J Haematol. 2014 May; 165(3):409-12. PMID: 24450944; PMCID: PMC3984601.
    37. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin J, Lyden PD, Zlokovic BV. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36. PMID: 24159062; PMCID: PMC3912991.
    38. Heeb MJ, Mesters RM, Fernández JA, Hackeng TM, Nakasone RK, Griffin J. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation. Thromb Haemost. 2013 Aug; 110(2):275-82. PMID: 23892573; PMCID: PMC3733499.
    39. Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin J, Goldman SA, Zlokovic BV. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013 Apr 03; 33(14):6181-90. PMID: 23554499; PMCID: PMC3707621.
    40. Wang Y, Sinha RK, Mosnier LO, Griffin J, Zlokovic BV. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. PMID: 23541526; PMCID: PMC3812054.
    41. Wang Y, Zhao Z, Chow N, Ali T, Griffin J, Zlokovic BV. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res. 2013 Apr 24; 1507:97-104. PMID: 23438513; PMCID: PMC3739836.
    42. von Drygalski A, Furlan-Freguia C, Ruf W, Griffin J, Mosnier LO. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):769-76. PMID: 23393392; PMCID: PMC3735365.
    43. Burnier L, Fernández JA, Griffin J. Antibody SPC-54 provides acute in vivo blockage of the murine protein C system. Blood Cells Mol Dis. 2013 Apr; 50(4):252-8. PMID: 23385154; PMCID: PMC3594351.
    44. Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin J, Davis TP, Zlokovic B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des. 2013; 19(42):7479-85. PMID: 24372304; PMCID: PMC4040367.
    45. Deguchi H, Elias DJ, Navarro S, España F, Griffin J. Elevated serum amyloid A is associated with venous thromboembolism. Thromb Haemost. 2013 Feb; 109(2):358-9. PMID: 23255027; PMCID: PMC3579663.
    46. Mosnier LO, Sinha RK, Burnier L, Bouwens EA, Griffin J. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood. 2012 Dec 20; 120(26):5237-46. PMID: 23149848; PMCID: PMC3537315.
    47. Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin J, Koenen RR, Hackeng TM. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. J Am Chem Soc. 2012 Nov 28; 134(47):19318-21. PMID: 23066897.
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    48. von Drygalski A, Furlan-Freguia C, Mosnier LO, Yegneswaran S, Ruf W, Griffin J. Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux. Thromb Haemost. 2012 Nov; 108(5):981-91. PMID: 23052565; PMCID: PMC3597782.
    49. Wang Y, Zhang Z, Chow N, Davis TP, Griffin J, Chopp M, Zlokovic BV. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke. 2012 Sep; 43(9):2444-9. PMID: 22811462; PMCID: PMC3429704.
    50. Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin J, Baum C, Weiler H, Hauer-Jensen M. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med. 2012 Jul; 18(7):1123-9. PMID: 22729286; PMCID: PMC3491776.
    51. Griffin J, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. Int J Hematol. 2012 Apr; 95(4):333-45. PMID: 22477541; PMCID: PMC3413316.
    52. Williams PD, Zlokovic BV, Griffin J, Pryor KE, Davis TP. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22. PMID: 22632606; PMCID: PMC3472038.
    53. Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin J, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood. 2012 Jan 19; 119(3):874-83. PMID: 22117049; PMCID: PMC3398751.
    54. Raife TJ, Dwyre DM, Stevens JW, Erger RA, Leo L, Wilson KM, Fernández JA, Wilder J, Kim HS, Griffin J, Maeda N, Lentz SR. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2509-17. PMID: 21885846; PMCID: PMC3202707.
    55. Hansen JB, Fernández JA, Borch KH, Griffin J, Brox JH, Braekkan SK. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism. Thromb Res. 2012 Apr; 129(4):502-7. PMID: 21777953; PMCID: PMC3480311.
    56. Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, Griffin J. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 01; 21(13):4108-14. PMID: 21632247.
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    57. Zlokovic BV, Griffin J. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 2011 Apr; 34(4):198-209. PMID: 21353711; PMCID: PMC3491752.
    58. Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin J, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13. PMID: 21291561; PMCID: PMC3042387.
    59. Bir N, Lafargue M, Howard M, Goolaerts A, Roux J, Carles M, Cohen MJ, Iles KE, Fernández JA, Griffin J, Pittet JF. Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):632-41. PMID: 21257925; PMCID: PMC3175583.
    60. Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin J. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorg Med Chem Lett. 2011 May 01; 21(9):2692-6. PMID: 21215619; PMCID: PMC3081996.
    61. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin J, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. PMID: 21084607; PMCID: PMC3012432.
    62. Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin J, Huettner CS, Castellino FJ, Weiler H. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest. 2010 Sep; 120(9):3167-78. PMID: 20714108; PMCID: PMC2929901.
    63. Cramer TJ, Griffin J, Gale AJ. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va. Pathophysiol Haemost Thromb. 2010; 37(1):17-23. PMID: 20501981; PMCID: PMC2974842.
    64. Cheung MC, Albers JJ, Kennedy H, Deguchi H, Elias DJ, Averell PM, Griffin J, Marcovina SM. Association of Apo(a)isoform size with dyslipoproteinemia in male venous thrombosis patients. Clin Chim Acta. 2010 Sep 06; 411(17-18):1279-83. PMID: 20488173; PMCID: PMC3427714.
    65. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin J, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. PMID: 19841542.
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    66. Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin J. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31. PMID: 19815836; PMCID: PMC2791928.
    67. Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernández JA, Schapira M, Hackeng TM, Griffin J, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009 Sep 10; 114(11):2307-14. PMID: 19567881; PMCID: PMC2745849.
    68. Schuepbach RA, Feistritzer C, Fernández JA, Griffin J, Riewald M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost. 2009 Apr; 101(4):724-33. PMID: 19350118; PMCID: PMC2680237.
    69. Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin J, Zlokovic BV. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci. 2009 Mar; 29(6):1119-30. PMID: 19302148; PMCID: PMC2692517.
    70. Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernández JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin J. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood. 2009 Jun 04; 113(23):5970-8. PMID: 19244160; PMCID: PMC2700330.
    71. Heeb MJ, Prashun D, Griffin J, Bouma BN. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J. 2009 Jul; 23(7):2244-53. PMID: 19244162; PMCID: PMC2704590.
    72. Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin J, Chow N, Zlokovic BV. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem. 2009 Apr; 109(1):116-24. PMID: 19166505; PMCID: PMC2692505.
    73. Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin J, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 2009 Mar 19; 113(12):2859-66. PMID: 19141861; PMCID: PMC2661868.
    74. Yegneswaran S, Nguyen PM, Gale AJ, Griffin J. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C. Thromb Haemost. 2009 Jan; 101(1):55-61. PMID: 19132189; PMCID: PMC2730196.
    75. Yang XV, Banerjee Y, Fernández JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin J. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):274-9. PMID: 19116273; PMCID: PMC2629184.
    76. Cheung MC, Wolfbauer G, Deguchi H, Fernández JA, Griffin J, Albers JJ. Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology. Biochim Biophys Acta. 2009 Mar; 1791(3):206-11. PMID: 19162221; PMCID: PMC2733856.
    77. Thiyagarajan M, Fernández JA, Lane SM, Griffin J, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. PMID: 19036971; PMCID: PMC2742231.
    78. Yegneswaran S, Hackeng TM, Dawson PE, Griffin J. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. J Biol Chem. 2008 Nov 28; 283(48):33046-52. PMID: 18784085; PMCID: PMC2586267.
    79. Pecheniuk NM, Elias DJ, Deguchi H, Averell PM, Griffin J. Elevated plasma fibronectin levels associated with venous thromboembolism. Thromb Haemost. 2008 Aug; 100(2):224-8. PMID: 18690341; PMCID: PMC2909754.
    80. Pecheniuk NM, Elias DJ, Xu X, Griffin J. Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry. Thromb Haemost. 2008 Feb; 99(2):453-5. PMID: 18278202.
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    81. Deguchi H, Fernández JA, Griffin J. Plasma cholesteryl ester transfer protein and blood coagulability. Thromb Haemost. 2007 Dec; 98(6):1160-4. PMID: 18064308.
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    82. Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin J, Weiler H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007 Oct 01; 204(10):2439-48. PMID: 17893198; PMCID: PMC2118455.
    83. Mosnier LO, Yang XV, Griffin J. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem. 2007 Nov 09; 282(45):33022-33. PMID: 17872949.
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    84. Yegneswaran S, Kojima Y, Nguyen PM, Gale AJ, Heeb MJ, Griffin J. Factor Va residues 311-325 represent an activated protein C binding region. J Biol Chem. 2007 Sep 28; 282(39):28353-61. PMID: 17646160.
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    85. Gale AJ, Yegneswaran S, Xu X, Pellequer JL, Griffin J. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. J Biol Chem. 2007 Jul 27; 282(30):21848-55. PMID: 17553804.
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    86. Eichinger S, Pecheniuk NM, Hron G, Deguchi H, Schemper M, Kyrle PA, Griffin J. High-density lipoprotein and the risk of recurrent venous thromboembolism. Circulation. 2007 Mar 27; 115(12):1609-14. PMID: 17372172.
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    87. Gruber A, Marzec UM, Bush L, Di Cera E, Fernández JA, Berny MA, Tucker EI, McCarty OJ, Griffin J, Hanson SR. Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood. 2007 May 01; 109(9):3733-40. PMID: 17227834; PMCID: PMC1874578.
    88. Raivio P, Fernández JA, Kuitunen A, Griffin J, Lassila R, Petäjä J. Activation of protein C and hemodynamic recovery after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2007 Jan; 133(1):44-51. PMID: 17198779.
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    89. Mosnier LO, Zlokovic BV, Griffin J. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. PMID: 17110453.
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    90. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin J, Chopp M, Zlokovic BV. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85. PMID: 17072311.
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    91. Mosnier LO, Griffin J. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities. Front Biosci. 2006 Sep 01; 11:2381-99. PMID: 16720321.
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    92. Fernández JA, Lentz SR, Dwyre DM, Griffin J. A novel ELISA for mouse activated protein C in plasma. J Immunol Methods. 2006 Jul 31; 314(1-2):174-81. PMID: 16828789.
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    93. Mineo C, Deguchi H, Griffin J, Shaul PW. Endothelial and antithrombotic actions of HDL. Circ Res. 2006 Jun 09; 98(11):1352-64. PMID: 16763172.
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    94. Feistritzer C, Schuepbach RA, Mosnier LO, Bush LA, Di Cera E, Griffin J, Riewald M. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem. 2006 Jul 21; 281(29):20077-84. PMID: 16709569.
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    95. Fernández JA, Vento AE, Jormalainen M, Griffin J, Pesonen E, Syrjälä M, Repo H, Jansson SE, Rämö OJ, Petäjä J. Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects. Cardiovasc Drugs Ther. 2006 Apr; 20(2):113-21. PMID: 16761191.
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    96. Griffin J, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. PMID: 16464623.
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    97. Lindstrom O, Kylanpaa L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin J, Repo H, Petaja J. Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis. Crit Care. 2006 Feb; 10(1):R16. PMID: 16420659; PMCID: PMC1550818.
    98. Ilmakunnas M, Pesonen EJ, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin J, Repo H, Siitonen S, Petäjä J. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation. Crit Care Med. 2006 Feb; 34(2):426-32. PMID: 16424724.
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    99. Tanaka KA, Fernández JA, Marzec UM, Kelly AB, Mohri M, Griffin J, Hanson SR, Gruber A. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates. Br J Haematol. 2006 Jan; 132(2):197-203. PMID: 16398653.
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    100. Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin J, Chopp M. Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7. PMID: 16130108.
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    101. Turunen AJ, Fernández JA, Lindgren L, Salmela KT, Kyllönen LE, Mäkisalo H, Griffin J, Siitonen SM, Petäjä J, Pesonen EJ. Activated protein C reduces graft neutrophil activation in clinical renal transplantation. Am J Transplant. 2005 Sep; 5(9):2204-12. PMID: 16095499.
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    102. Deguchi H, Pecheniuk NM, Elias DJ, Averell PM, Griffin J. High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. Circulation. 2005 Aug 09; 112(6):893-9. PMID: 16087810.
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    103. Contreras JL, Eckstein C, Smyth CA, Bilbao G, Vilatoba M, Ringland SE, Young C, Thompson JA, Fernández JA, Griffin J, Eckhoff DE. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes. 2004 Nov; 53(11):2804-14. PMID: 15504960.
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    104. Liu D, Cheng T, Guo H, Fernández JA, Griffin J, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec; 10(12):1379-83. PMID: 15516929.
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    105. Yegneswaran S, Mesters RM, Fernández JA, Griffin J. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex. J Biol Chem. 2004 Nov 19; 279(47):49019-25. PMID: 15331602.
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    106. Mosnier LO, Gale AJ, Yegneswaran S, Griffin J. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood. 2004 Sep 15; 104(6):1740-4. PMID: 15178575.
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    107. Griffin J, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53. PMID: 15118526.
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    108. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin J, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72. PMID: 14980205.
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    109. Gale AJ, Griffin J. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va. Proteins. 2004 Feb 15; 54(3):433-41. PMID: 14747992.
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    110. Deguchi H, Yegneswaran S, Griffin J. Sphingolipids as bioactive regulators of thrombin generation. J Biol Chem. 2004 Mar 26; 279(13):12036-42. PMID: 14722105.
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    111. McDougal PG, Griffin J. Enantiotracin. Bioorg Med Chem Lett. 2003 Jul 07; 13(13):2239-40. PMID: 12798342.
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    112. Mosnier LO, Griffin J. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J. 2003 Jul 01; 373(Pt 1):65-70. PMID: 12683950; PMCID: PMC1223481.
    113. Griffin J, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R. Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7830-5. PMID: 12808148; PMCID: PMC164673.
    114. Yegneswaran S, Mesters RM, Griffin J. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. J Biol Chem. 2003 Aug 29; 278(35):33312-8. PMID: 12805370.
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    115. Griffin J, Linsell MS, Nodwell MB, Chen Q, Pace JL, Quast KL, Krause KM, Farrington L, Wu TX, Higgins DL, Jenkins TE, Christensen BG, Judice JK. Multivalent drug design. Synthesis and in vitro analysis of an array of vancomycin dimers. J Am Chem Soc. 2003 May 28; 125(21):6517-31. PMID: 12785792.
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    116. Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin J. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. PMID: 12737945.
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    117. Liu D, Guo H, Griffin J, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6. PMID: 12665496.
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    118. Ilmakunnas M, Petäjä J, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin J, Jansson SE, Repo H, Pesonen EJ. Activation of protein C during reperfusion in clinical liver transplantation. Transplantation. 2003 Feb 27; 75(4):467-72. PMID: 12605111.
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    119. Slungaard A, Fernandez JA, Griffin J, Key NS, Long JR, Piegors DJ, Lentz SR. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood. 2003 Jul 01; 102(1):146-51. PMID: 12609838.
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    120. Dömötör E, Benzakour O, Griffin J, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801. PMID: 12586611.
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    121. Cheng T, Liu D, Griffin J, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. PMID: 12563316.
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    122. Yegneswaran S, Deguchi H, Griffin J. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles. J Biol Chem. 2003 Apr 25; 278(17):14614-21. PMID: 12560338.
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    123. Khrenov AV, Ananyeva NM, Griffin J, Saenko EL. Coagulation pathways in atherothrombosis. Trends Cardiovasc Med. 2002 Oct; 12(7):317-24. PMID: 12458095.
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    124. Lentz SR, Piegors DJ, Fernández JA, Erger RA, Arning E, Malinow MR, Griffin J, Bottiglieri T, Haynes WG, Heistad DD. Effect of hyperhomocysteinemia on protein C activation and activity. Blood. 2002 Sep 15; 100(6):2108-12. PMID: 12200374.
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    125. Gale AJ, Xu X, Pellequer JL, Getzoff ED, Griffin J. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C. Protein Sci. 2002 Sep; 11(9):2091-101. PMID: 12192065; PMCID: PMC2373598.
    126. Heeb MJ, Paganini-Hill A, Griffin J, Fisher M. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender. Blood Cells Mol Dis. 2002 Sep-Oct; 29(2):139-44. PMID: 12490280.
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    127. Heeb MJ, Griffin J. Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements. Blood Cells Mol Dis. 2002 Sep-Oct; 29(2):190-9. PMID: 12490286.
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    128. Lentz SR, Miller FJ, Piegors DJ, Erger RA, Fernández JA, Griffin J, Heistad DD. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation. 2002 Aug 13; 106(7):842-6. PMID: 12176958.
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    129. Simmelink MJ, de Groot PG, Derksen RH, Fernandez JA, Griffin J. Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors. Blood. 2002 Dec 01; 100(12):4232-3. PMID: 12393585.
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    130. Wu TK, Griffin J. Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis. Biochemistry. 2002 Jul 02; 41(26):8238-44. PMID: 12081472.
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    131. Griffin J, Zlokovic B, Fernández JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. PMID: 12124682.
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    132. Fernández JA, Gruber A, Heeb MJ, Griffin J. Protein C pathway impairment in nonsymptomatic cigarette smokers. Blood Cells Mol Dis. 2002 Jul-Aug; 29(1):73-82. PMID: 12482406.
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    133. Gale AJ, Tsavaler A, Griffin J. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C. J Biol Chem. 2002 Aug 09; 277(32):28836-40. PMID: 12063259.
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    134. Simmelink MJ, Fernández JA, Derksen RH, Griffin J, de Groot PG. Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II. Br J Haematol. 2002 Jun; 117(3):676-84. PMID: 12028041.
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    135. Yegneswaran S, Fernández JA, Griffin J, Dawson PE. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe. Chem Biol. 2002 Apr; 9(4):485-94. PMID: 11983337.
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    136. Deguchi H, Fernández JA, Griffin J. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S. J Biol Chem. 2002 Mar 15; 277(11):8861-5. PMID: 11741960.
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    137. Gravert DJ, Griffin J. Steric and Electronic Effects, Enantiospecificity, and Reactive Orientation in DNA Binding/Cleaving by Substituted Derivatives of [SalenMn(III)](+). Inorg Chem. 1996 Aug 14; 35(17):4837-4847. PMID: 11666683.
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    138. Lee J, Griffin J, Nicas TI. Solid-Phase Total Synthesis of Bacitracin A. J Org Chem. 1996 Jun 14; 61(12):3983-3986. PMID: 11667271.
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