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John Griffin

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Protein C Pathways
    NIH/NHLBI R01HL142975Jun 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
    NIH/NIAID U01AI133561Jun 5, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Human exomics genotyping-driven discovery and characterization of proteins related to clinical thrombosis, blood coagulation and thrombin generation
    NIH/NHLBI R01HL133728Sep 15, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Murine Protein C and Protein S Proof of Principle Research
    NIH/NHLBI R01HL104074Jan 1, 2011 - Jul 31, 2011
    Role: Principal Investigator
    Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    NIH/NHLBI RC1HL101034Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Drug Engineering of Transglutaminase 2 Inhibitors
    NIH/NIDDK R41DK081244Feb 1, 2009 - Jan 31, 2011
    Role: Principal Investigator
    Novel targets and agents to treat thrombotic disorders
    NIH/NHLBI R01HL078684Sep 24, 2004 - Aug 31, 2005
    Role: Principal Investigator
    Structure and Function of Protein C
    NIH/NHLBI R01HL052246Dec 1, 1994 - Dec 31, 2017
    Role: Principal Investigator
    STRUCTURE AND FUNCTION OF PROTEIN C
    NIH/NHLBI R37HL052246Dec 1, 1994 - Dec 26, 2004
    Role: Principal Investigator
    IMPROVED FUNCTIONS FOR RECEPTOR LIKE ANTIBIOTICS
    NIH/NIGMS R01GM051122May 1, 1994 - Aug 31, 1998
    Role: Principal Investigator
    NOVEL SEMISYNTHETIC DERIVATIVES OF VANCOMYCIN
    NIH/NIGMS R21GM051122May 1, 1994 - Apr 30, 1996
    Role: Principal Investigator
    Thrombus Formation and Antithrombotic Intervention
    NIH/NHLBI P01HL031950Apr 1, 1984 - Jun 30, 2016
    Role: Principal Investigator
    PROTEIN C--AN ANTITHROMBOTIC-PROFIBRINOLYTIC AGENT
    NIH/NHLBI R01HL024891Aug 1, 1982 - Jul 31, 1992
    Role: Principal Investigator
    Proteins of Coagulation Pathways
    NIH/NHLBI R01HL021544Jul 1, 1977 - Aug 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Deguchi H, Guo Z, Hayat M, Pflimlin E, Lear S, Shen W, Griffin JH. Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombin activation. J Biol Chem. 2019 Sep 03. PMID: 31481465.
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    2. Müller-Calleja N, Hollerbach A, Ritter S, Pedrosa DG, Strand D, Graf C, Reinhardt C, Strand S, Poncelet P, Griffin JH, Lackner KJ, Ruf W. Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis. Blood. 2019 Aug 21. PMID: 31434703.
      View in: PubMed
    3. Coleman JR, Moore EE, Zilberman-Rudenko J, Samuels JM, Cohen MJ, Silliman CC, Banerjee A, Sauaia A, Griffin JH, Deguchi H. Rapid Communication: Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects. Shock. 2019 Jul 30. PMID: 31365491.
      View in: PubMed
    4. Sinha RK, Flynn R, Zaiken M, Paz K, Gavin AL, Nemazee D, Fernández JA, Xu X, Griffin JH, Blazar BR. Activated Protein C Ameliorates Chronic Graft-Versus-Host Disease by PAR1-dependent Biased Cell Signaling on T-cells. Blood. 2019 Jun 26. PMID: 31243040.
      View in: PubMed
    5. Rajput PS, Lamb JA, Fernández JÁ, Bai J, Pereira BR, Lei IF, Leung J, Griffin JH, Lyden PD. Neuroprotection and vasculoprotection using genetically targeted protease-ligands. Brain Res. 2019 Jul 15; 1715:13-20. PMID: 30880117.
      View in: PubMed
    6. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 Feb 04; 216(2):279-293. PMID: 30647119.
      View in: PubMed
    7. Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV. Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 Jan; 85(1):125-136. PMID: 30450637.
      View in: PubMed
    8. Mukherjee P, Leman LJ, Griffin JH, Ghadiri MR. Design of a DNA-Programmed Plasminogen Activator. J Am Chem Soc. 2018 Nov 14; 140(45):15516-15524. PMID: 30347143.
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    9. Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C, protease activated receptor 1, and neuroprotection. Blood. 2018 Jul 12; 132(2):159-169. PMID: 29866816.
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    10. Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 06 01; 73(6):1586-1594. PMID: 29514266.
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    11. Healy LD, Rigg RA, Griffin JH, McCarty OJT. Regulation of immune cell signaling by activated protein C. J Leukoc Biol. 2018 Mar 30. PMID: 29601101.
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    12. Martos L, Ramón LA, Oto J, Fernández-Pardo Á, Bonanad S, Cid AR, Gruber A, Griffin JH, España F, Navarro S, Medina P. a2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:a2M Levels Are Associated with Venous Thromboembolism. Thromb Haemost. 2018 04; 118(4):630-638. PMID: 29448296.
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    13. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 05; 36(5):796-806. PMID: 29396891.
      View in: PubMed
    14. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171. PMID: 29343482.
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    15. Prince R, Bologna L, Manetti M, Melchiorre D, Rosa I, Dewarrat N, Suardi S, Amini P, Fernández JA, Burnier L, Quarroz C, Reina Caro MD, Matsumura Y, Kremer Hovinga JA, Griffin JH, Simon HU, Ibba-Manneschi L, Saller F, Calzavarini S, Angelillo-Scherrer A. Targeting anticoagulant protein S to improve hemostasis in hemophilia. Blood. 2018 03 22; 131(12):1360-1371. PMID: 29317453.
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    16. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. PMID: 28923278.
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    17. Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. Blood. 2017 12 14; 130(24):2664-2677. PMID: 28882883.
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    18. Fernández JA, Xu X, Sinha RK, Mosnier LO, Sanner MF, Griffin JH. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S. Blood Adv. 2017 Aug 08; 1(18):1423-1426. PMID: 29296783.
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    19. Deguchi H, Navarro S, Payne AB, Elias DJ, Dowling NF, Austin HD, España F, Medina P, Hooper WC, Griffin JH. Low level of the plasma sphingolipid, glucosylceramide, is associated with thrombotic diseases. Res Pract Thromb Haemost. 2017 Jul; 1(1):33-40. PMID: 29202121.
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    20. Deguchi H, Elias DJ, Griffin JH. Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk. Res Pract Thromb Haemost. 2017 Jul; 1(1):93-102. PMID: 29082360.
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    21. Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin JH, McCarty OJT. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017 05 26; 292(21):8616-8629. PMID: 28408624.
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    22. Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. PMID: 27758767.
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    23. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5. PMID: 27548576.
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    24. Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJT, Cohen MJ, Griffin JH. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood. 2016 10 06; 128(14):1870-1878. PMID: 27421960.
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    25. Burnier L, Boroujerdi A, Fernández JA, Welser-Alves JV, Griffin JH, Milner R. Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C. Exp Neurol. 2016 09; 283(Pt A):396-403. PMID: 27412766.
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    26. Deguchi H, Banerjee Y, Elias DJ, Griffin JH. Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism. J Atheroscler Thromb. 2016 Oct 01; 23(10):1159-1167. PMID: 27169917.
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    27. Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thromb Res. 2016 May; 141 Suppl 2:S62-4. PMID: 27207428.
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    28. Alsultan A, Gale AJ, Kurban K, Khalifah M, Albadr FB, Griffin JH. Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis. Thromb Res. 2016 Jul; 143:17-21. PMID: 27172833.
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    29. Gale AJ, Bhat V, Pellequer JL, Griffin JH, Mosnier LO, Von Drygalski A. Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding. Pharm Res. 2016 06; 33(6):1517-26. PMID: 26960296.
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    30. Sinha RK, Yang XV, Fernández JA, Xu X, Mosnier LO, Griffin JH. Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):518-24. PMID: 26800564.
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    31. Bhat V, von Drygalski A, Gale AJ, Griffin JH, Mosnier LO. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thromb Haemost. 2016 Mar; 115(3):551-61. PMID: 26466980.
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    32. Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood. 2015 Nov 19; 126(21):2415-23. PMID: 26341257.
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    33. Amar AP, Griffin JH, Zlokovic BV. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344. PMID: 26388732.
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    34. Yegneswaran S, Banerjee Y, Fernández JA, Deguchi H, Griffin JH. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex. PLoS One. 2015; 10(8):e0135025. PMID: 26263376.
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    35. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, Miyata T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015 Nov 05; 126(19):2247-53. PMID: 26251307.
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    36. Deguchi H, Wolfbauer G, Cheung MC, Banerjee Y, Elias DJ, Fernández JA, Albers JJ, Griffin JH. Inhibition of thrombin generation in human plasma by phospholipid transfer protein. Thromb J. 2015; 13:24. PMID: 26185485.
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    37. Deguchi H, Banerjee Y, Trauger S, Siuzdak G, Kalisiak E, Fernández JA, Hoang L, Tran M, Yegneswaran S, Elias DJ, Griffin JH. Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data. Blood. 2015 Sep 24; 126(13):1595-600. PMID: 26175037.
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    38. Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 2015 May 07; 125(19):2898-907. PMID: 25824691.
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    39. Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30; 125(18):2845-54. PMID: 25733582.
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    40. Fernandez JA, Deguchi H, Banka CL, Witztum JL, Griffin JH. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):570-2. PMID: 25550205.
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    41. Mosnier LO, Zlokovic BV, Griffin JH. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost. 2014 Nov; 112(5):883-92. PMID: 25230930.
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    42. von Drygalski A, Bhat V, Gale AJ, Burnier L, Cramer TJ, Griffin JH, Mosnier LO. An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C. PLoS One. 2014; 9(8):e104304. PMID: 25127130.
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    43. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. PMID: 24591593.
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    44. Deguchi H, Elias DJ, Trauger S, Zhang HM, Kalisiak E, Siuzdak G, Griffin JH. Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids. Br J Haematol. 2014 May; 165(3):409-12. PMID: 24450944.
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    45. Deguchi H, Elias DJ, Griffin JH. Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution. J Thromb Haemost. 2014 Jan; 12(1):90-2. PMID: 24406066.
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    46. von Drygalski A, Cramer TJ, Bhat V, Griffin JH, Gale AJ, Mosnier LO. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant. J Thromb Haemost. 2014; 12(3):363-72. PMID: 24818532.
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    47. Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. J Thromb Haemost. 2013 Nov; 11(11):2059-62. PMID: 24034518.
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    48. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36. PMID: 24159062.
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    49. Heeb MJ, Mesters RM, Fernández JA, Hackeng TM, Nakasone RK, Griffin JH. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation. Thromb Haemost. 2013 Aug; 110(2):275-82. PMID: 23892573.
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    50. Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013 Apr 03; 33(14):6181-90. PMID: 23554499.
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    51. Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. PMID: 23541526.
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    52. Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res. 2013 Apr 24; 1507:97-104. PMID: 23438513.
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    53. von Drygalski A, Furlan-Freguia C, Ruf W, Griffin JH, Mosnier LO. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):769-76. PMID: 23393392.
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    54. Burnier L, Fernández JA, Griffin JH. Antibody SPC-54 provides acute in vivo blockage of the murine protein C system. Blood Cells Mol Dis. 2013 Apr; 50(4):252-8. PMID: 23385154.
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    55. Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des. 2013; 19(42):7479-85. PMID: 24372304.
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    56. Deguchi H, Elias DJ, Navarro S, España F, Griffin JH. Elevated serum amyloid A is associated with venous thromboembolism. Thromb Haemost. 2013 Feb; 109(2):358-9. PMID: 23255027.
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    57. Mosnier LO, Sinha RK, Burnier L, Bouwens EA, Griffin JH. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood. 2012 Dec 20; 120(26):5237-46. PMID: 23149848.
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    58. Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. J Am Chem Soc. 2012 Nov 28; 134(47):19318-21. PMID: 23066897.
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    59. von Drygalski A, Furlan-Freguia C, Mosnier LO, Yegneswaran S, Ruf W, Griffin JH. Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux. Thromb Haemost. 2012 Nov; 108(5):981-91. PMID: 23052565.
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    60. Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke. 2012 Sep; 43(9):2444-9. PMID: 22811462.
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    61. Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med. 2012 Jul; 18(7):1123-9. PMID: 22729286.
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    62. Griffin JH, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. Int J Hematol. 2012 Apr; 95(4):333-45. PMID: 22477541.
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    63. Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22. PMID: 22632606.
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    64. Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood. 2012 Jan 19; 119(3):874-83. PMID: 22117049.
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    65. Raife TJ, Dwyre DM, Stevens JW, Erger RA, Leo L, Wilson KM, Fernández JA, Wilder J, Kim HS, Griffin JH, Maeda N, Lentz SR. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2509-17. PMID: 21885846.
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    66. Hansen JB, Fernández JA, Borch KH, Griffin JH, Brox JH, Braekkan SK. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism. Thromb Res. 2012 Apr; 129(4):502-7. PMID: 21777953.
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    67. Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, Griffin JH. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 01; 21(13):4108-14. PMID: 21632247.
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    68. Zlokovic BV, Griffin JH. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 2011 Apr; 34(4):198-209. PMID: 21353711.
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    69. Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13. PMID: 21291561.
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    70. Bir N, Lafargue M, Howard M, Goolaerts A, Roux J, Carles M, Cohen MJ, Iles KE, Fernández JA, Griffin JH, Pittet JF. Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):632-41. PMID: 21257925.
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    71. Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorg Med Chem Lett. 2011 May 01; 21(9):2692-6. PMID: 21215619.
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    72. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. PMID: 21084607.
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    73. Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest. 2010 Sep; 120(9):3167-78. PMID: 20714108.
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    74. Cramer TJ, Griffin JH, Gale AJ. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va. Pathophysiol Haemost Thromb. 2010; 37(1):17-23. PMID: 20501981.
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    75. Cheung MC, Albers JJ, Kennedy H, Deguchi H, Elias DJ, Averell PM, Griffin JH, Marcovina SM. Association of Apo(a)isoform size with dyslipoproteinemia in male venous thrombosis patients. Clin Chim Acta. 2010 Sep 06; 411(17-18):1279-83. PMID: 20488173.
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    76. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. PMID: 19841542.
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    77. Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31. PMID: 19815836.
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    78. Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernández JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009 Sep 10; 114(11):2307-14. PMID: 19567881.
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    79. Schuepbach RA, Feistritzer C, Fernández JA, Griffin JH, Riewald M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost. 2009 Apr; 101(4):724-33. PMID: 19350118.
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    80. Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci. 2009 Mar; 29(6):1119-30. PMID: 19302148.
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    81. Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernández JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin JH. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood. 2009 Jun 04; 113(23):5970-8. PMID: 19244160.
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    82. Heeb MJ, Prashun D, Griffin JH, Bouma BN. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J. 2009 Jul; 23(7):2244-53. PMID: 19244162.
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    83. Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem. 2009 Apr; 109(1):116-24. PMID: 19166505.
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    84. Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 2009 Mar 19; 113(12):2859-66. PMID: 19141861.
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    85. Yegneswaran S, Nguyen PM, Gale AJ, Griffin JH. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C. Thromb Haemost. 2009 Jan; 101(1):55-61. PMID: 19132189.
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    86. Yang XV, Banerjee Y, Fernández JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):274-9. PMID: 19116273.
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    87. Cheung MC, Wolfbauer G, Deguchi H, Fernández JA, Griffin JH, Albers JJ. Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology. Biochim Biophys Acta. 2009 Mar; 1791(3):206-11. PMID: 19162221.
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    88. Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. PMID: 19036971.
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    89. Yegneswaran S, Hackeng TM, Dawson PE, Griffin JH. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. J Biol Chem. 2008 Nov 28; 283(48):33046-52. PMID: 18784085.
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    90. Pecheniuk NM, Elias DJ, Deguchi H, Averell PM, Griffin JH. Elevated plasma fibronectin levels associated with venous thromboembolism. Thromb Haemost. 2008 Aug; 100(2):224-8. PMID: 18690341.
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    91. Heeb MJ, Gandrille S, Fernandez JA, Griffin JH, Fedullo PF. Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations. J Thromb Haemost. 2008 Jul; 6(7):1235-7. PMID: 18433462.
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    92. White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernández JA, Griffin JH, Gruber A, McCarty OJ. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. J Thromb Haemost. 2008 Jun; 6(6):995-1002. PMID: 18489431.
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    93. Pecheniuk NM, Elias DJ, Xu X, Griffin JH. Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry. Thromb Haemost. 2008 Feb; 99(2):453-5. PMID: 18278202.
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    94. Deguchi H, Fernández JA, Griffin JH. Plasma cholesteryl ester transfer protein and blood coagulability. Thromb Haemost. 2007 Dec; 98(6):1160-4. PMID: 18064308.
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    95. Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007 Oct 01; 204(10):2439-48. PMID: 17893198.
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    96. Mosnier LO, Yang XV, Griffin JH. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem. 2007 Nov 09; 282(45):33022-33. PMID: 17872949.
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    97. Yegneswaran S, Kojima Y, Nguyen PM, Gale AJ, Heeb MJ, Griffin JH. Factor Va residues 311-325 represent an activated protein C binding region. J Biol Chem. 2007 Sep 28; 282(39):28353-61. PMID: 17646160.
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    98. Griffin JH, Fernández JA, Gale AJ, Mosnier LO. Activated protein C. J Thromb Haemost. 2007 Jul; 5 Suppl 1:73-80. PMID: 17635713.
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    99. Gale AJ, Yegneswaran S, Xu X, Pellequer JL, Griffin JH. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. J Biol Chem. 2007 Jul 27; 282(30):21848-55. PMID: 17553804.
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    100. Eichinger S, Pecheniuk NM, Hron G, Deguchi H, Schemper M, Kyrle PA, Griffin JH. High-density lipoprotein and the risk of recurrent venous thromboembolism. Circulation. 2007 Mar 27; 115(12):1609-14. PMID: 17372172.
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    101. Gruber A, Marzec UM, Bush L, Di Cera E, Fernández JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR. Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood. 2007 May 01; 109(9):3733-40. PMID: 17227834.
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    102. Raivio P, Fernández JA, Kuitunen A, Griffin JH, Lassila R, Petäjä J. Activation of protein C and hemodynamic recovery after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2007 Jan; 133(1):44-51. PMID: 17198779.
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    103. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. PMID: 17110453.
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    104. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85. PMID: 17072311.
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    105. Radtke KP, Griffin JH, Riceberg J, Gale AJ. Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays. J Thromb Haemost. 2007 Jan; 5(1):102-8. PMID: 17059431.
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    106. Mosnier LO, Griffin JH. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities. Front Biosci. 2006 Sep 01; 11:2381-99. PMID: 16720321.
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    107. Pecheniuk NM, Deguchi H, Elias DJ, Xu X, Griffin JH. Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males. J Thromb Haemost. 2006 Sep; 4(9):2080-2. PMID: 16961620.
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    108. Fernández JA, Lentz SR, Dwyre DM, Griffin JH. A novel ELISA for mouse activated protein C in plasma. J Immunol Methods. 2006 Jul 31; 314(1-2):174-81. PMID: 16828789.
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    109. Mineo C, Deguchi H, Griffin JH, Shaul PW. Endothelial and antithrombotic actions of HDL. Circ Res. 2006 Jun 09; 98(11):1352-64. PMID: 16763172.
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    110. Gale AJ, Radtke KP, Cunningham MA, Chamberlain D, Pellequer JL, Griffin JH. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants. J Thromb Haemost. 2006 Jun; 4(6):1315-22. PMID: 16706977.
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    111. Feistritzer C, Schuepbach RA, Mosnier LO, Bush LA, Di Cera E, Griffin JH, Riewald M. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem. 2006 Jul 21; 281(29):20077-84. PMID: 16709569.
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    112. Fernández JA, Pecheniuk NM, Deguchi H, Elias DJ, Griffin JH. Is adiponectin implicated in venous thromboembolism? J Thromb Haemost. 2006 May; 4(5):1151-2. PMID: 16689775.
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    113. Fernández JA, Vento AE, Jormalainen M, Griffin JH, Pesonen E, Syrjälä M, Repo H, Jansson SE, Rämö OJ, Petäjä J. Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects. Cardiovasc Drugs Ther. 2006 Apr; 20(2):113-21. PMID: 16761191.
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    114. Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. PMID: 16464623.
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    115. Gruber A, Fernández JA, Bush L, Marzec U, Griffin JH, Hanson SR, DI Cera E. Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates. J Thromb Haemost. 2006 Feb; 4(2):392-7. PMID: 16420571.
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    116. Lindstrom O, Kylanpaa L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petaja J. Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis. Crit Care. 2006 Feb; 10(1):R16. PMID: 16420659.
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    117. Ilmakunnas M, Pesonen EJ, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin JH, Repo H, Siitonen S, Petäjä J. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation. Crit Care Med. 2006 Feb; 34(2):426-32. PMID: 16424724.
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    118. Tanaka KA, Fernández JA, Marzec UM, Kelly AB, Mohri M, Griffin JH, Hanson SR, Gruber A. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates. Br J Haematol. 2006 Jan; 132(2):197-203. PMID: 16398653.
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    119. Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7. PMID: 16130108.
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    120. Turunen AJ, Fernández JA, Lindgren L, Salmela KT, Kyllönen LE, Mäkisalo H, Griffin JH, Siitonen SM, Petäjä J, Pesonen EJ. Activated protein C reduces graft neutrophil activation in clinical renal transplantation. Am J Transplant. 2005 Sep; 5(9):2204-12. PMID: 16095499.
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    121. Deguchi H, Pecheniuk NM, Elias DJ, Averell PM, Griffin JH. High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. Circulation. 2005 Aug 09; 112(6):893-9. PMID: 16087810.
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    122. Deguchi H, Bouma BN, Middeldorp S, Lee YM, Griffin JH. Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide. J Thromb Haemost. 2005 May; 3(5):935-8. PMID: 15869587.
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    123. Pecheniuk NM, Deguchi H, Griffin JH. Cholesterol enhances phospholipid-dependent activated protein C anticoagulant activity. J Thromb Haemost. 2005 Feb; 3(2):340-5. PMID: 15670041.
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    124. Contreras JL, Eckstein C, Smyth CA, Bilbao G, Vilatoba M, Ringland SE, Young C, Thompson JA, Fernández JA, Griffin JH, Eckhoff DE. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes. 2004 Nov; 53(11):2804-14. PMID: 15504960.
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    125. Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livneh A, Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Ann Rheum Dis. 2004 Nov; 63(11):1445-9. PMID: 15479893.
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    126. Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec; 10(12):1379-83. PMID: 15516929.
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    127. Yegneswaran S, Mesters RM, Fernández JA, Griffin JH. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex. J Biol Chem. 2004 Nov 19; 279(47):49019-25. PMID: 15331602.
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    128. Mosnier LO, Gale AJ, Yegneswaran S, Griffin JH. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood. 2004 Sep 15; 104(6):1740-4. PMID: 15178575.
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    129. Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53. PMID: 15118526.
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    130. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72. PMID: 14980205.
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    131. Gale AJ, Griffin JH. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va. Proteins. 2004 Feb 15; 54(3):433-41. PMID: 14747992.
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    132. Deguchi H, Yegneswaran S, Griffin JH. Sphingolipids as bioactive regulators of thrombin generation. J Biol Chem. 2004 Mar 26; 279(13):12036-42. PMID: 14722105.
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    133. McDougal PG, Griffin JH. Enantiotracin. Bioorg Med Chem Lett. 2003 Jul 07; 13(13):2239-40. PMID: 12798342.
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    134. Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J. 2003 Jul 01; 373(Pt 1):65-70. PMID: 12683950.
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    135. Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R. Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7830-5. PMID: 12808148.
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    136. Yegneswaran S, Mesters RM, Griffin JH. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. J Biol Chem. 2003 Aug 29; 278(35):33312-8. PMID: 12805370.
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    137. Griffin JH, Linsell MS, Nodwell MB, Chen Q, Pace JL, Quast KL, Krause KM, Farrington L, Wu TX, Higgins DL, Jenkins TE, Christensen BG, Judice JK. Multivalent drug design. Synthesis and in vitro analysis of an array of vancomycin dimers. J Am Chem Soc. 2003 May 28; 125(21):6517-31. PMID: 12785792.
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    138. Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. PMID: 12737945.
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    139. Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6. PMID: 12665496.
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    140. Slungaard A, Fernandez JA, Griffin JH, Key NS, Long JR, Piegors DJ, Lentz SR. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood. 2003 Jul 01; 102(1):146-51. PMID: 12609838.
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    141. Ilmakunnas M, Petäjä J, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin JH, Jansson SE, Repo H, Pesonen EJ. Activation of protein C during reperfusion in clinical liver transplantation. Transplantation. 2003 Feb 27; 75(4):467-72. PMID: 12605111.
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    142. Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801. PMID: 12586611.
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    143. Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. PMID: 12563316.
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    144. Yegneswaran S, Deguchi H, Griffin JH. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles. J Biol Chem. 2003 Apr 25; 278(17):14614-21. PMID: 12560338.
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    145. Khrenov AV, Ananyeva NM, Griffin JH, Saenko EL. Coagulation pathways in atherothrombosis. Trends Cardiovasc Med. 2002 Oct; 12(7):317-24. PMID: 12458095.
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    146. Lentz SR, Piegors DJ, Fernández JA, Erger RA, Arning E, Malinow MR, Griffin JH, Bottiglieri T, Haynes WG, Heistad DD. Effect of hyperhomocysteinemia on protein C activation and activity. Blood. 2002 Sep 15; 100(6):2108-12. PMID: 12200374.
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    147. Gale AJ, Xu X, Pellequer JL, Getzoff ED, Griffin JH. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C. Protein Sci. 2002 Sep; 11(9):2091-101. PMID: 12192065.
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    148. Heeb MJ, Paganini-Hill A, Griffin JH, Fisher M. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender. Blood Cells Mol Dis. 2002 Sep-Oct; 29(2):139-44. PMID: 12490280.
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    149. Heeb MJ, Griffin JH. Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements. Blood Cells Mol Dis. 2002 Sep-Oct; 29(2):190-9. PMID: 12490286.
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    150. Lentz SR, Miller FJ, Piegors DJ, Erger RA, Fernández JA, Griffin JH, Heistad DD. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation. 2002 Aug 13; 106(7):842-6. PMID: 12176958.
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    151. Simmelink MJ, de Groot PG, Derksen RH, Fernandez JA, Griffin JH. Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors. Blood. 2002 Dec 01; 100(12):4232-3. PMID: 12393585.
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    152. Kottke-Marchant K, Bahit MC, Granger CB, Zoldhelyi P, Ardissino D, Brooks L, Griffin JH, Potthoff RF, Van de Werf F, Califf RM, Topol EJ. Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes; the GUSTO-IIb haemostasis substudy. Eur Heart J. 2002 Aug; 23(15):1202-12. PMID: 12127922.
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    153. Wu TK, Griffin JH. Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis. Biochemistry. 2002 Jul 02; 41(26):8238-44. PMID: 12081472.
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    154. Griffin JH, Zlokovic B, Fernández JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. PMID: 12124682.
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    155. Fernández JA, Gruber A, Heeb MJ, Griffin JH. Protein C pathway impairment in nonsymptomatic cigarette smokers. Blood Cells Mol Dis. 2002 Jul-Aug; 29(1):73-82. PMID: 12482406.
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    156. Gale AJ, Tsavaler A, Griffin JH. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C. J Biol Chem. 2002 Aug 09; 277(32):28836-40. PMID: 12063259.
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    157. Simmelink MJ, Fernández JA, Derksen RH, Griffin JH, de Groot PG. Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II. Br J Haematol. 2002 Jun; 117(3):676-84. PMID: 12028041.
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    158. Yegneswaran S, Fernández JA, Griffin JH, Dawson PE. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe. Chem Biol. 2002 Apr; 9(4):485-94. PMID: 11983337.
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    159. Deguchi H, Fernández JA, Griffin JH. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S. J Biol Chem. 2002 Mar 15; 277(11):8861-5. PMID: 11741960.
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    160. Griffin JH, Fernández JA, Deguchi H. Plasma lipoproteins, hemostasis and thrombosis. Thromb Haemost. 2001 Jul; 86(1):386-94. PMID: 11487028.
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    161. Petäjä J, Pesonen E, Fernández JA, Griffin JH, Repo H, Jansson SE, Vento AE, Rämö OJ. Activated protein C and inflammation in human myocardium after heart surgery. Am J Hematol. 2001 Jul; 67(3):210-2. PMID: 11391722.
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    162. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. PMID: 11282913.
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    163. Buckner FS, Griffin JH, Wilson AJ, Van Voorhis WC. Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors. Antimicrob Agents Chemother. 2001 Apr; 45(4):1210-5. PMID: 11257036.
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    164. Deguchi H, Fernández JA, Pabinger I, Heit JA, Griffin JH. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway. Blood. 2001 Apr 01; 97(7):1907-14. PMID: 11264150.
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    165. Grody WW, Griffin JH, Taylor AK, Korf BR, Heit JA. American College of Medical Genetics consensus statement on factor V Leiden mutation testing. Genet Med. 2001 Mar-Apr; 3(2):139-48. PMID: 11280951.
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    166. Rintelen C, Yegneswaran S, Griffin JH. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation. Thromb Haemost. 2001 Feb; 85(2):274-9. PMID: 11246547.
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    167. Hackeng TM, Fernández JA, Dawson PE, Kent SB, Griffin JH. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14074-8. PMID: 11106381.
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    168. Pellequer JL, Gale AJ, Getzoff ED, Griffin JH. Three-dimensional model of coagulation factor Va bound to activated protein C. Thromb Haemost. 2000 Nov; 84(5):849-57. PMID: 11127867.
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    169. Hackeng TM, Yegneswaran S, Johnson AE, Griffin JH. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S. Biochem J. 2000 Aug 01; 349 Pt 3:757-64. PMID: 10903136.
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    170. Gale AJ, Heeb MJ, Griffin JH. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites. Blood. 2000 Jul 15; 96(2):585-93. PMID: 10887122.
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    171. Mesters RM, Helterbrand J, Utterback BG, Yan B, Chao YB, Fernandez JA, Griffin JH, Hartman DL. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications. Crit Care Med. 2000 Jul; 28(7):2209-16. PMID: 10921542.
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    172. Marx PF, Hackeng TM, Dawson PE, Griffin JH, Meijers JC, Bouma BN. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage. J Biol Chem. 2000 Apr 28; 275(17):12410-5. PMID: 10777524.
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    173. Fernández JA, Kojima K, Petäjä J, Hackeng TM, Griffin JH. Cardiolipin enhances protein C pathway anticoagulant activity. Blood Cells Mol Dis. 2000 Apr; 26(2):115-23. PMID: 10753602.
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    174. Deguchi H, Fernandez JA, Hackeng TM, Banka CL, Griffin JH. Cardiolipin is a normal component of human plasma lipoproteins. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1743-8. PMID: 10677528.
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    175. Gale AJ, Pellequer JL, Getzoff ED, Griffin JH. Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII. Thromb Haemost. 2000 Jan; 83(1):78-85. PMID: 10669159.
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    176. Griffin JH, Deguchi H, Fernandez JA. Causes of thrombophilia yet to be discovered: a personal view. Haemostasis. 2000; 30 Suppl 2:26-33. PMID: 11251338.
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    177. Heeb MJ, Kojima Y, Rosing J, Tans G, Griffin JH. C-terminal residues 621-635 of protein S are essential for binding to factor Va. J Biol Chem. 1999 Dec 17; 274(51):36187-92. PMID: 10593904.
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    178. Bouma BN, Mosnier LO, Meijers JC, Griffin JH. Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation. Thromb Haemost. 1999 Dec; 82(6):1703-8. PMID: 10613658.
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    179. Fernández JA, Petäjä J, Griffin JH. Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C. Thromb Haemost. 1999 Nov; 82(5):1462-8. PMID: 10595639.
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    180. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. PMID: 10559029.
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    181. Petäjä J, Pesonen E, Fernández JA, Vento AE, Rämö OJ, Griffin JH. Cardiopulmonary bypass and activation of antithrombotic plasma protein C. J Thorac Cardiovasc Surg. 1999 Sep; 118(3):422-9; discussion 429-31. PMID: 10469954.
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    182. Hackeng TM, Griffin JH, Dawson PE. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10068-73. PMID: 10468563.
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    183. Zivelin A, Gitel S, Griffin JH, Xu X, Fernandez JA, Martinowitz U, Cohen Y, Halkin H, Seligsohn U, Inbal A. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C. Blood. 1999 Aug 01; 94(3):895-901. PMID: 10419879.
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    184. Lentz SR, Fernández JA, Griffin JH, Piegors DJ, Erger RA, Malinow MR, Heistad DD. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1744-50. PMID: 10397693.
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    185. Xu X, Bauer KA, Griffin JH. Two multiplex PCR-based DNA assays for the thrombosis risk factors prothrombin G20210A and coagulation factor V G1691A polymorphisms. Thromb Res. 1999 Mar 15; 93(6):265-9. PMID: 10093967.
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    186. Macko RF, Killewich LA, Fernández JA, Cox DK, Gruber A, Griffin JH. Brain-specific protein C activation during carotid artery occlusion in humans. Stroke. 1999 Mar; 30(3):542-5. PMID: 10066849.
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    187. Griffin JH, Kojima K, Banka CL, Curtiss LK, Fernández JA. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C. J Clin Invest. 1999 Jan; 103(2):219-27. PMID: 9916134.
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    188. Pellequer JL, Gale AJ, Griffin JH, Getzoff ED. Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains. Blood Cells Mol Dis. 1998 Dec; 24(4):448-61. PMID: 9880241.
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    189. Petäjä J, Fernández JA, Fellman V, Griffin JH. Upregulation of the antithrombotic protein C pathway at birth. Pediatr Hematol Oncol. 1998 Nov-Dec; 15(6):489-99. PMID: 9842642.
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    190. Mounier CM, Hackeng TM, Schaeffer F, Faure G, Bon C, Griffin JH. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa. J Biol Chem. 1998 Sep 11; 273(37):23764-72. PMID: 9726985.
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    191. Hackeng TM, Dawson PE, Kent SB, Griffin JH. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module. Biopolymers. 1998 Aug; 46(2):53-63. PMID: 9664841.
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    192. Kojima Y, Heeb MJ, Gale AJ, Hackeng TM, Griffin JH. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va. J Biol Chem. 1998 Jun 12; 273(24):14900-5. PMID: 9614093.
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    193. Fernández JA, Griffin JH, Chang GT, Stam J, Reitsma PH, Bertina RM, Bouma BN. Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein. Blood Cells Mol Dis. 1998 Jun; 24(2):101-12; discussion 113. PMID: 9628846.
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    194. Petäjä J, Hakala L, Rasi V, Griffin JH. Circulating activated protein C in subjects with heterozygous Gln506-factor V. Haemostasis. 1998 Jan-Feb; 28(1):31-6. PMID: 9885368.
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    195. Petäjä JM, Griffin JH. Activated protein C resistance: What have we learned now that the dust has settled? Ann Med. 1997 Dec; 29(6):469-72. PMID: 9562511.
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    196. Smiley ST, Boyer SN, Heeb MJ, Griffin JH, Grusby MJ. Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11484-9. PMID: 9326636.
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    197. Wang L, Zoppè M, Hackeng TM, Griffin JH, Lee KF, Verma IM. A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11563-6. PMID: 9326649.
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    198. Fernández JA, Petäjä J, Gruber A, Griffin JH. Activated protein C correlates inversely with thrombin levels in resting healthy individuals. Am J Hematol. 1997 Sep; 56(1):29-31. PMID: 9298864.
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    199. Hackeng TM, Mounier CM, Bon C, Dawson PE, Griffin JH, Kent SB. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7845-50. PMID: 9223275.
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    200. Fernández JA, Hackeng TM, Kojima K, Griffin JH. The carbohydrate moiety of factor V modulates inactivation by activated protein C. Blood. 1997 Jun 15; 89(12):4348-54. PMID: 9192757.
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    201. Petäjä J, Fernández JA, Gruber A, Griffin JH. Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C. J Clin Invest. 1997 Jun 01; 99(11):2655-63. PMID: 9169495.
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    202. Fernández JA, Heeb MJ, Radtke KP, Griffin JH. Potent blood coagulant activity of human semen due to prostasome-bound tissue factor. Biol Reprod. 1997 Mar; 56(3):757-63. PMID: 9047022.
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    203. Zivelin A, Griffin JH, Xu X, Pabinger I, Samama M, Conard J, Brenner B, Eldor A, Seligsohn U. A single genetic origin for a common Caucasian risk factor for venous thrombosis. Blood. 1997 Jan 15; 89(2):397-402. PMID: 9002940.
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    204. Gale AJ, Sun X, Heeb MJ, Griffin JH. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va. Protein Sci. 1997 Jan; 6(1):132-40. PMID: 9007985.
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    205. Macko RF, Ameriso SF, Gruber A, Griffin JH, Fernandez JA, Barndt R, Quismorio FP, Weiner JM, Fisher M. Impairments of the protein C system and fibrinolysis in infection-associated stroke. Stroke. 1996 Nov; 27(11):2005-11. PMID: 8898806.
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    206. Petäjä J, Lundström U, Sairanen H, Marttinen E, Griffin JH. Central venous thrombosis after cardiac operations in children. J Thorac Cardiovasc Surg. 1996 Oct; 112(4):883-9. PMID: 8873713.
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    207. Heeb MJ, Kojima Y, Hackeng TM, Griffin JH. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va. Protein Sci. 1996 Sep; 5(9):1883-9. PMID: 8880912.
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    208. Gravert DJ, Griffin JH. Steric and Electronic Effects, Enantiospecificity, and Reactive Orientation in DNA Binding/Cleaving by Substituted Derivatives of [SalenMn(III)](+). Inorg Chem. 1996 Aug 14; 35(17):4837-4847. PMID: 11666683.
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    209. Brenner B, Zivelin A, Lanir N, Greengard JS, Griffin JH, Seligsohn U. Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis. Blood. 1996 Aug 01; 88(3):877-80. PMID: 8704244.
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    210. Fisher M, Fernandez JA, Ameriso SF, Xie D, Gruber A, Paganini-Hill A, Griffin JH. Activated protein C resistance in ischemic stroke not due to factor V arginine506-->glutamine mutation. Stroke. 1996 Jul; 27(7):1163-6. PMID: 8685921.
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    211. Lee J, Griffin JH, Nicas TI. Solid-Phase Total Synthesis of Bacitracin A. J Org Chem. 1996 Jun 14; 61(12):3983-3986. PMID: 11667271.
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    212. Goldman RC, Zakula D, Capobianco JO, Sharpe BA, Griffin JH. Inhibition of 2,3-oxidosqualene-lanosterol cyclase in Candida albicans by pyridinium ion-based inhibitors. Antimicrob Agents Chemother. 1996 Apr; 40(4):1044-7. PMID: 8849227.
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    213. España F, Sánchez-Cuenca J, Estellés A, Gilabert J, Griffin JH, Heeb MJ. Quantitative immunoassay for complexes of prostate-specific antigen with alpha2-macroglobulin. Clin Chem. 1996 Apr; 42(4):545-50. PMID: 8605671.
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    214. Gillespie DL, Carrington LR, Griffin JH, Alving BM. Resistance to activated protein C: a common inherited cause of venous thrombosis. Ann Vasc Surg. 1996 Mar; 10(2):174-7. PMID: 8733870.
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    215. Sifontes MT, Nuss R, Jacobson LJ, Griffin JH, Manco-Johnson MJ. Thrombosis in otherwise well children with the factor V Leiden mutation. J Pediatr. 1996 Mar; 128(3):324-8. PMID: 8774498.
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    216. Gravert DJ, Griffin JH. Specific DNA cleavage by manganese(III) complexes. Met Ions Biol Syst. 1996; 33:515-36. PMID: 8742854.
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    217. Radtke KP, Greengard JS, Fernández JA, Villoutreix BO, Griffin JH. A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations. Thromb Haemost. 1996 Jan; 75(1):62-9. PMID: 8713781.
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    218. Rose IC, Sharpe BA, Lee RC, Griffin JH, Capobianco JO, Zakula D, Goldman RC. Design, synthesis and in vitro evaluation of pyridinium ion based cyclase inhibitors and antifungal agents. Bioorg Med Chem. 1996 Jan; 4(1):97-103. PMID: 8689245.
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    219. Villoutreix BO, Fernández JA, Teleman O, Griffin JH. Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S. Protein Eng. 1995 Dec; 8(12):1253-8. PMID: 8869637.
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    220. Greengard JS, Xu X, Gandrille S, Griffin JH. Alternative PCR method for diagnosis of mutation causing activated protein C resistant Gln506-factor V. Thromb Res. 1995 Dec 01; 80(5):441-3. PMID: 8588206.
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    221. Griffin JH. Blood coagulation. The thrombin paradox. Nature. 1995 Nov 23; 378(6555):337-8. PMID: 7477366.
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    222. Heeb MJ, España F, Gittes RF, Griffin JH. Prostate specific antigen-alpha 2-macroglobulin complexes in prostate cancer patient sera. Biochem Mol Biol Int. 1995 Nov; 37(5):917-23. PMID: 8624498.
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    223. Spek CA, Greengard JS, Griffin JH, Bertina RM, Reitsma PH. Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites. J Biol Chem. 1995 Oct 13; 270(41):24216-21. PMID: 7592627.
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    224. Radtke KP, Fernández JA, Villoutreix BO, Greengard JS, Griffin JH. Characterization of a cDNA for rhesus monkey protein C inhibitor--evidence for N-terminal involvement in heparin stimulation. Thromb Haemost. 1995 Oct; 74(4):1079-87. PMID: 8560417.
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    225. Griffin JH. A conference of crosstalk: the Gordon Research Conference in Bioorganic Chemistry. Chem Biol. 1995 Aug; 2(8):501-2. PMID: 9383452.
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    226. Griffin JH, Heeb MJ, Kojima Y, Fernández JA, Kojima K, Hackeng TM, Greengard JS. Activated protein C resistance: molecular mechanisms. Thromb Haemost. 1995 Jul; 74(1):444-8. PMID: 8578503.
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    227. Gandrille S, Greengard JS, Alhenc-Gelas M, Juhan-Vague I, Abgrall JF, Jude B, Griffin JH, Aiach M. Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM. Blood. 1995 Jul 01; 86(1):219-24. PMID: 7795227.
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    228. Heeb MJ, Kojima Y, Greengard JS, Griffin JH. Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V. Blood. 1995 Jun 15; 85(12):3405-11. PMID: 7780127.
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    229. Le DT, Griffin JH, Greengard JS, Mujumdar V, Rapaport SI. Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant. Blood. 1995 Apr 01; 85(7):1704-11. PMID: 7703480.
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    230. Greengard JS, Fernandez JA, Radtke KP, Griffin JH. Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C. Biochem J. 1995 Jan 15; 305 ( Pt 2):397-403. PMID: 7832752.
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    231. Calkins T, Greengard J, Griffin JH, Bylund D. Anticoagulant response to activated protein C: method validation and assay comparison. J Clin Lab Anal. 1995; 9(6):418-23. PMID: 8587012.
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    232. Greengard JS, Eichinger S, Griffin JH, Bauer KA. Brief report: variability of thrombosis among homozygous siblings with resistance to activated protein C due to an Arg-->Gln mutation in the gene for factor V. N Engl J Med. 1994 Dec 08; 331(23):1559-62. PMID: 7969326.
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    233. Greengard JS, Griffin JH, Fisher CL. Possible structural implications of 20 mutations in the protein C protease domain. Thromb Haemost. 1994 Dec; 72(6):869-73. PMID: 7740456.
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    234. Villoutreix BO, Getzoff ED, Griffin JH. A structural model for the prostate disease marker, human prostate-specific antigen. Protein Sci. 1994 Nov; 3(11):2033-44. PMID: 7535613.
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    235. Radtke KP, Fernández JA, Greengard JS, Tang WW, Wilson CB, Loskutoff DJ, Scharrer I, Griffin JH. Protein C inhibitor is expressed in tubular cells of human kidney. J Clin Invest. 1994 Nov; 94(5):2117-24. PMID: 7525654.
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    236. Fernández JA, Villoutreix BO, Hackeng TM, Griffin JH, Bouma BN. Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies. Biochemistry. 1994 Sep 20; 33(37):11073-8. PMID: 7727359.
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    237. Tsay W, Greengard JS, Griffin JH. Exonic polymorphisms in the protein C gene: interethnic comparison between Caucasians and Asians. Hum Genet. 1994 Aug; 94(2):177-8. PMID: 8045564.
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    238. Shi Z, Buntel CJ, Griffin JH. Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7370-4. PMID: 8041797.
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    239. Sun X, Evatt B, Griffin JH. Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia. Blood. 1994 Jun 01; 83(11):3120-5. PMID: 8193349.
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    240. Greengard JS, Sun X, Xu X, Fernandez JA, Griffin JH, Evatt B. Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet. 1994 May 28; 343(8909):1361-2. PMID: 7910348.
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    241. Gruber A, Mori E, del Zoppo GJ, Waxman L, Griffin JH. Alteration of fibrin network by activated protein C. Blood. 1994 May 01; 83(9):2541-8. PMID: 8167339.
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    242. Greengard JS, Fisher CL, Villoutreix B, Griffin JH. Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: patterns revealed by three-dimensional molecular modelling of mutations of the protease domain. Proteins. 1994 Apr; 18(4):367-80. PMID: 8208728.
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    243. Fisher CL, Greengard JS, Griffin JH. Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen. Protein Sci. 1994 Apr; 3(4):588-99. PMID: 8003977.
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    244. Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2728-32. PMID: 8146182.
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    245. Fernández JA, Griffin JH. A protein S binding site on C4b-binding protein involves beta chain residues 31-45. J Biol Chem. 1994 Jan 28; 269(4):2535-40. PMID: 8300581.
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    246. España F, Estellés A, Fernández PJ, Gilabert J, Sánchez-Cuenca J, Griffin JH. Evidence for the regulation of urokinase and tissue type plasminogen activators by the serpin, protein C inhibitor, in semen and blood plasma. Thromb Haemost. 1993 Dec 20; 70(6):989-94. PMID: 8165623.
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    247. Mesters RM, Heeb MJ, Griffin JH. A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va. Biochemistry. 1993 Nov 30; 32(47):12656-63. PMID: 8251484.
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    248. Gruber A, Pál A, Kiss RG, Sas G, Griffin JH. Generation of activated protein C during thrombolysis. Lancet. 1993 Nov 20; 342(8882):1275-6. PMID: 7901587.
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    249. Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest. 1993 Oct; 92(4):2003-12. PMID: 8408654.
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    250. Tsay W, Greengard JS, Montgomery RR, McPherson RA, Fucci JC, Koerper MA, Coughlin J, Griffin JH. Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency. Blood Coagul Fibrinolysis. 1993 Oct; 4(5):791-6. PMID: 8292730.
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    251. Griffin JH, Evatt B, Wideman C, Fernández JA. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood. 1993 Oct 01; 82(7):1989-93. PMID: 8400251.
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    252. Mesters RM, Heeb MJ, Griffin JH. Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C. Protein Sci. 1993 Sep; 2(9):1482-9. PMID: 8401232.
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    253. Conard J, Bauer KA, Gruber A, Griffin JH, Schwarz HP, Horellou MH, Samama MM, Rosenberg RD. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency. Blood. 1993 Aug 15; 82(4):1159-64. PMID: 8353282.
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    254. Fernández JA, Heeb MJ, Griffin JH. Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein. J Biol Chem. 1993 Aug 05; 268(22):16788-94. PMID: 7688369.
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    255. Phillips DJ, Greengard JS, Fernandez JA, Ribeiro M, Evatt BL, Griffin JH, Hooper WC. Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells. J Neurochem. 1993 Jul; 61(1):344-7. PMID: 8515282.
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    256. Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem. 1993 Feb 05; 268(4):2872-7. PMID: 8428962.
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    257. Berrettini M, Schleef RR, Heeb MJ, Hopmeier P, Griffin JH. Assembly and expression of an intrinsic factor IX activator complex on the surface of cultured human endothelial cells. J Biol Chem. 1992 Oct 05; 267(28):19833-9. PMID: 1400299.
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    258. Bakker HM, Tans G, Janssen-Claessen T, Thomassen MC, Hemker HC, Griffin JH, Rosing J. The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C. Eur J Biochem. 1992 Aug 15; 208(1):171-8. PMID: 1387359.
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    259. Griffin JH, Gruber A, Fernández JA. Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin. Blood. 1992 Jun 15; 79(12):3203-11. PMID: 1534488.
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    260. Gruber A, Griffin JH. Direct detection of activated protein C in blood from human subjects. Blood. 1992 May 01; 79(9):2340-8. PMID: 1571547.
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    261. Greengard JS, Griffin JH. High molecular weight kininogen receptor. Methods Enzymol. 1992; 215:369-82. PMID: 1331710.
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    262. Mesters RM, Houghten RA, Griffin JH. Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity. J Biol Chem. 1991 Dec 25; 266(36):24514-9. PMID: 1761551.
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    263. Richman D, Shih CK, Lowy I, Rose J, Prodanovich P, Goff S, Griffin J. Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11241-5. PMID: 1722324.
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    264. Gruber A, Harker LA, Hanson SR, Kelly AB, Griffin JH. Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates. Circulation. 1991 Dec; 84(6):2454-62. PMID: 1835678.
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    265. Heeb MJ, Gruber A, Griffin JH. Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin. J Biol Chem. 1991 Sep 15; 266(26):17606-12. PMID: 1716632.
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    266. Vicente V, España F, Tabernero D, Estellés A, Aznar J, Hendl S, Griffin JH. Evidence of activation of the protein C pathway during acute vascular damage induced by Mediterranean spotted fever. Blood. 1991 Jul 15; 78(2):416-22. PMID: 1648982.
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    267. Geiger M, Priglinger U, Griffin JH, Binder BR. Urinary protein C inhibitor. Glycosaminoclycans synthesized by the epithelial kidney cell line TCL-598 enhance its interaction with urokinase. J Biol Chem. 1991 Jun 25; 266(18):11851-7. PMID: 1646816.
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    268. Tans G, Rosing J, Thomassen MC, Heeb MJ, Zwaal RF, Griffin JH. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood. 1991 Jun 15; 77(12):2641-8. PMID: 2043766.
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    269. España F, Gilabert J, Aznar J, Estellés A, Kobayashi T, Griffin JH. Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia. Am J Obstet Gynecol. 1991 May; 164(5 Pt 1):1310-6. PMID: 1852102.
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    270. España F, Gruber A, Heeb MJ, Hanson SR, Harker LA, Griffin JH. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons. Blood. 1991 Apr 15; 77(8):1754-60. PMID: 1849759.
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    271. España F, Estelles A, Griffin JH, Aznar J. Interaction of plasma kallikrein with protein C inhibitor in purified mixtures and in plasma. Thromb Haemost. 1991 Jan 23; 65(1):46-51. PMID: 1850876.
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    272. Kuhn LA, Griffin JH, Fisher CL, Greengard JS, Bouma BN, España F, Tainer JA. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8506-10. PMID: 2172989.
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    273. España F, Vicente V, Tabernero D, Scharrer I, Griffin JH. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thromb Res. 1990 Aug 01; 59(3):593-608. PMID: 2173167.
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    274. Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA. Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis. Circulation. 1990 Aug; 82(2):578-85. PMID: 2372904.
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    275. Mack DP, Sluka JP, Shin JA, Griffin JH, Simon MI, Dervan PB. Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site. Biochemistry. 1990 Jul 17; 29(28):6561-7. PMID: 2204416.
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    276. Heeb MJ, Bischoff R, Courtney M, Griffin JH. Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358. J Biol Chem. 1990 Feb 05; 265(4):2365-9. PMID: 2298753.
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    277. España F, Estelles A, Griffin JH, Aznar J, Gilabert J. Aprotinin (trasylol) is a competitive inhibitor of activated protein C. Thromb Res. 1989 Dec 15; 56(6):751-6. PMID: 2483763.
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    278. España F, Griffin JH. Determination of functional and antigenic protein C inhibitor and its complexes with activated protein C in plasma by ELISA's. Thromb Res. 1989 Sep 15; 55(6):671-82. PMID: 2551066.
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    279. España F, Berrettini M, Griffin JH. Purification and characterization of plasma protein C inhibitor. Thromb Res. 1989 Aug 01; 55(3):369-84. PMID: 2551064.
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    280. Geiger M, Huber K, Wojta J, Stingl L, Espana F, Griffin JH, Binder BR. Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo. Blood. 1989 Aug 01; 74(2):722-8. PMID: 2752144.
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    281. Berrettini M, Schleef RR, España F, Loskutoff DJ, Griffin JH. Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system. J Biol Chem. 1989 Jul 15; 264(20):11738-43. PMID: 2787318.
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    282. Schwarz HP, Heeb MJ, Lottenberg R, Roberts H, Griffin JH. Familial protein S deficiency with a variant protein S molecule in plasma and platelets. Blood. 1989 Jul; 74(1):213-21. PMID: 2526663.
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    283. Gladson CL, Schleef RR, Binder BR, Loskutoff DJ, Griffin JH. A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor. Blood. 1989 Jul; 74(1):173-81. PMID: 2787675.
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    284. Geiger M, White TM, Griffin JH. Functional assays for protein C activity and protein C inhibitor activity in plasma. Thromb Haemost. 1989 Feb 28; 61(1):86-92. PMID: 2546280.
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    285. Gruber A, Griffin JH, Harker LA, Hanson SR. Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model. Blood. 1989 Feb 15; 73(3):639-42. PMID: 2917194.
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    286. Heeb MJ, Mosher D, Griffin JH. Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation. Blood. 1989 Feb; 73(2):455-61. PMID: 2521800.
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    287. Heeb MJ, España F, Griffin JH. Inhibition and complexation of activated protein C by two major inhibitors in plasma. Blood. 1989 Feb; 73(2):446-54. PMID: 2917184.
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    288. Heeb MJ, Schwarz HP, White T, Lämmle B, Berrettini M, Griffin JH. Immunoblotting studies of the molecular forms of protein C in plasma. Thromb Res. 1988 Oct 01; 52(1):33-43. PMID: 3201394.
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    289. Heeb MJ, Griffin JH. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. J Biol Chem. 1988 Aug 25; 263(24):11613-6. PMID: 3261294.
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    290. Lämmle B, Zuraw BL, Heeb MJ, Schwarz HP, Berrettini M, Curd JG, Griffin JH. Detection and quantitation of cleaved and uncleaved high molecular weight kininogen in plasma by ligand blotting with radiolabeled plasma prekallikrein or factor XI. Thromb Haemost. 1988 Apr 08; 59(2):151-61. PMID: 3388291.
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    291. Geiger M, Heeb MJ, Binder BR, Griffin JH. Competition of activated protein C and urokinase for a heparin-dependent inhibitor. FASEB J. 1988 Apr; 2(7):2263-7. PMID: 3350241.
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    292. Schwarz HP, Muntean W, Watzke H, Richter B, Griffin JH. Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates. Blood. 1988 Mar; 71(3):562-5. PMID: 2964259.
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    293. Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost. 1988 Feb 25; 59(1):18-22. PMID: 2966450.
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    294. Tans G, Verkleij AJ, Yu J, Griffin JH. Sulfatide bilayers as a surface for contact activation in human plasma. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):1002-7. PMID: 3426605.
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    295. Gladson CL, Groncy P, Griffin JH. Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency. Arch Dermatol. 1987 Dec; 123(12):1701a-1706a. PMID: 2961308.
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    296. Heeb MJ, España F, Geiger M, Collen D, Stump DC, Griffin JH. Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3. J Biol Chem. 1987 Nov 25; 262(33):15813-6. PMID: 2824468.
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    297. Schwarz HP, Schernthaner G, Griffin JH. Decreased plasma levels of protein S in well-controlled type I diabetes mellitus. Thromb Haemost. 1987 Apr 07; 57(2):240. PMID: 2955541.
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    298. Griffin JH, Heeb MJ, Schwarz HP. Plasma protein S deficiency and thromboembolic disease. Prog Hematol. 1987; 15:39-49. PMID: 2971986.
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    299. Schwarz HP, Heeb MJ, Lämmle B, Berrettini M, Griffin JH. Quantitative immunoblotting of plasma and platelet protein S. Thromb Haemost. 1986 Dec 15; 56(3):382-6. PMID: 2436335.
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    300. Sakata Y, Loskutoff DJ, Gladson CL, Hekman CM, Griffin JH. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood. 1986 Dec; 68(6):1218-23. PMID: 3096399.
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    301. Cembrowski GS, Griffin JH, Mosher DF. Diagnostic efficacy of six plasma proteins in evaluating consumptive coagulopathies. Use of receiver operating characteristic curves to compare antithrombin III, plasminogen, alpha 2-plasmin inhibitor, fibronectin, prothrombin, and protein C. Arch Intern Med. 1986 Oct; 146(10):1997-2002. PMID: 3767544.
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    302. Berrettini M, Lämmle B, White T, Heeb MJ, Schwarz HP, Zuraw B, Curd J, Griffin JH. Detection of in vitro and in vivo cleavage of high molecular weight kininogen in human plasma by immunoblotting with monoclonal antibodies. Blood. 1986 Aug; 68(2):455-62. PMID: 3730610.
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    303. Lämmle B, Berrettini M, Griffin JH. Enhanced specificity of immunoblotting using radiolabeled antigen overlay: studies of blood coagulation factor XII and prekallikrein in plasma. Anal Biochem. 1986 Jul; 156(1):118-25. PMID: 3638135.
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    304. Bouma BN, Kerbiriou DM, Baker J, Griffin JH. Characterization of a variant prekallikrein, prekallikrein Long Beach, from a family with mixed cross-reacting material-positive and cross-reacting material-negative prekallikrein deficiency. J Clin Invest. 1986 Jul; 78(1):170-6. PMID: 3487556.
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    305. Greengard JS, Heeb MJ, Ersdal E, Walsh PN, Griffin JH. Binding of coagulation factor XI to washed human platelets. Biochemistry. 1986 Jul 01; 25(13):3884-90. PMID: 3017409.
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    306. Podack ER, Dahlbäck B, Griffin JH. Interaction of S-protein of complement with thrombin and antithrombin III during coagulation. Protection of thrombin by S-protein from antithrombin III inactivation. J Biol Chem. 1986 Jun 05; 261(16):7387-92. PMID: 3754869.
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    307. Bezeaud A, Drouet L, Leverger G, Griffin JH, Guillin MC. Effect of L-asparaginase therapy for acute lymphoblastic leukemia on plasma vitamin K-dependent coagulation factors and inhibitors. J Pediatr. 1986 May; 108(5 Pt 1):698-701. PMID: 2939229.
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    308. Lämmle B, Berrettini M, Schwarz HP, Heeb MJ, Griffin JH. Quantitative immunoblotting assay of blood coagulation factor XII. Thromb Res. 1986 Mar 15; 41(6):747-59. PMID: 3085274.
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    309. Schwarz HP, Heeb MJ, Wencel-Drake JD, Griffin JH. Identification and quantitation of protein S in human platelets. Blood. 1985 Dec; 66(6):1452-5. PMID: 2933098.
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    310. Sas G, Blaskó G, Petrö I, Griffin JH. A protein S deficient family with portal vein thrombosis. Thromb Haemost. 1985 Oct 30; 54(3):724. PMID: 2935967.
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    311. Bock PE, Shore JD, Tans G, Griffin JH. Protein-protein interactions in contact activation of blood coagulation. Binding of high molecular weight kininogen and the 5-(iodoacetamido) fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light chains. J Biol Chem. 1985 Oct 15; 260(23):12434-43. PMID: 3850090.
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    312. Rosing J, Tans G, Griffin JH. Surface-dependent activation of human factor XII (Hageman factor) by kallikrein and its light chain. Eur J Biochem. 1985 Sep 16; 151(3):531-8. PMID: 3875484.
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    313. Cosio FG, Harker C, Batard MA, Brandt JT, Griffin JH. Plasma concentrations of the natural anticoagulants protein C and protein S in patients with proteinuria. J Lab Clin Med. 1985 Aug; 106(2):218-22. PMID: 3160800.
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    314. Lämmle B, Griffin JH. Formation of the fibrin clot: the balance of procoagulant and inhibitory factors. Clin Haematol. 1985 Jun; 14(2):281-342. PMID: 2994929.
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    315. Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ. Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1121-5. PMID: 3871946.
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    316. Greengard JS, Griffin JH. Receptors for high molecular weight kininogen on stimulated washed human platelets. Biochemistry. 1984 Dec 18; 23(26):6863-9. PMID: 6099145.
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    317. Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. Plasma protein S deficiency in familial thrombotic disease. Blood. 1984 Dec; 64(6):1297-300. PMID: 6238642.
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    318. Gardiner JE, Griffin JH. Studies on human protein C inhibitor in normal and Factor V/VIII deficient plasmas. Thromb Res. 1984 Nov 01; 36(3):197-203. PMID: 6549082.
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    319. Griffin JH, Bezeaud A, Evatt B, Mosher D. Studies of protein C in thromboembolic disease. Ric Clin Lab. 1984 Jul-Sep; 14(3):469-73. PMID: 6395293.
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    320. Griffin JH. Clinical studies of protein C. Semin Thromb Hemost. 1984 Apr; 10(2):162-6. PMID: 6377499.
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    321. Fulcher CA, Gardiner JE, Griffin JH, Zimmerman TS. Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V. Blood. 1984 Feb; 63(2):486-9. PMID: 6419799.
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    322. Walsh PN, Tuszynski GP, Greengard JS, Griffin JH. The possible role of platelets in bypassing the contact phase of blood coagulation. Haematologia (Budap). 1984; 17(2):169-78. PMID: 6534825.
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    323. Branson HE, Katz J, Marble R, Griffin JH. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant. Lancet. 1983 Nov 19; 2(8360):1165-8. PMID: 6139528.
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    324. Bouma BN, Vlooswijk RA, Griffin JH. Immunologic studies of human coagulation factor XI and its complex with high molecular weight kininogen. Blood. 1983 Nov; 62(5):1123-31. PMID: 6626744.
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    325. van der Graaf F, Koedam JA, Griffin JH, Bouma BN. Interaction of human plasma kallikrein and its light chain with C1 inhibitor. Biochemistry. 1983 Sep 27; 22(20):4860-6. PMID: 6556071.
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    326. van der Graaf F, Greengard JS, Bouma BN, Kerbiriou DM, Griffin JH. Isolation and functional characterization of the active light chain of activated human blood coagulation factor XI. J Biol Chem. 1983 Aug 25; 258(16):9669-75. PMID: 6604052.
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    327. Tans G, Rosing J, Griffin JH. Sulfatide-dependent autoactivation of human blood coagulation Factor XII (Hageman Factor). J Biol Chem. 1983 Jul 10; 258(13):8215-22. PMID: 6553053.
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    328. Miles LA, Greengard JS, Griffin JH. A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen. Thromb Res. 1983 Feb 15; 29(4):407-17. PMID: 6344314.
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    329. Gardiner JE, Griffin JH. Human protein C and thromboembolic disease. Prog Hematol. 1983; 13:265-78. PMID: 6422505.
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    330. Bouma BN, Vlooswijk RA, Griffin JH. Immunological studies of human Factor XI and prekallikrein: demonstration of complex formation with high molecular weight kininogen. Adv Exp Med Biol. 1983; 156:109-13. PMID: 6552836.
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    331. Tans G, Griffin JH. Initiation of contact activation by sulfatides. Adv Exp Med Biol. 1983; 156:63-72. PMID: 6602464.
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    332. van der Graaf F, Tans G, Bouma BN, Griffin JH. Isolation and functional properties of the heavy and light chains of human plasma kallikrein. J Biol Chem. 1982 Dec 10; 257(23):14300-5. PMID: 6815193.
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    333. Marlar RA, Kleiss AJ, Griffin JH. An alternative extrinsic pathway of human blood coagulation. Blood. 1982 Dec; 60(6):1353-8. PMID: 7139124.
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    334. Griffin JH, Mosher DF, Zimmerman TS, Kleiss AJ. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation. Blood. 1982 Jul; 60(1):261-4. PMID: 6896290.
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    335. Miles LA, Plow EF, Donnelly KJ, Hougie C, Griffin JH. A bleeding disorder due to deficiency of alpha 2-antiplasmin. Blood. 1982 Jun; 59(6):1246-51. PMID: 7082827.
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    336. Marlar RA, Kleiss AJ, Griffin JH. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood. 1982 May; 59(5):1067-72. PMID: 6803853.
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    337. Tans G, Griffin JH. Properties of sulfatides in factor-XII-dependent contact activation. Blood. 1982 Jan; 59(1):69-75. PMID: 6914902.
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    338. Cochrane CG, Griffin JH. The biochemistry and pathophysiology of the contact system of plasma. Adv Immunol. 1982; 33:241-306. PMID: 6182767.
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    339. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981 Nov; 68(5):1370-3. PMID: 6895379.
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    340. Miles LA, Burnier JP, Verlander MS, Goodman M, Kleiss AJ, Griffin JH. Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents. Blood. 1981 Jun; 57(6):1015-24. PMID: 6452920.
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    341. Marlar RA, Griffin JH. Alternative pathways of thromboplastin-dependent activation of human factor X in plasma. Ann N Y Acad Sci. 1981; 370:325-35. PMID: 6943963.
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    342. Marlar RA, Kleiss AJ, Griffin JH. Human protein C: inactivation of factors V and VIII in plasma by the activated molecule. Ann N Y Acad Sci. 1981; 370:303-10. PMID: 6791548.
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    343. Walsh PN, Griffin JH. Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI. Blood. 1981 Jan; 57(1):106-18. PMID: 7004531.
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    344. Walsh PN, Griffin JH. Platelet-coagulant protein interactions in contact activation. Ann N Y Acad Sci. 1981; 370:241-52. PMID: 7023319.
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    345. Marlar RA, Griffin JH. Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease. J Clin Invest. 1980 Nov; 66(5):1186-9. PMID: 6253526.
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    346. Bouma BN, Kerbiriou DM, Vlooswijk RA, Griffin JH. Immunological studies of prekallikrein, kallikrein, and high-molecular-weight kininogen in normal and deficient plasmas and in normal plasma after cold-dependent activation. J Lab Clin Med. 1980 Oct; 96(4):693-709. PMID: 6903191.
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    347. Kerbiriou DM, Bouma BN, Griffin JH. Immunochemical studies of human high molecular weight kininogen and of its complexes with plasma prekallikrein or kallikrein. J Biol Chem. 1980 May 10; 255(9):3952-8. PMID: 6154706.
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    348. Bouma BN, Miles LA, Beretta G, Griffin JH. Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate. Biochemistry. 1980 Mar 18; 19(6):1151-60. PMID: 6768384.
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    349. Wiggins RC, Loskutoff DJ, Cochrane CG, Griffin JH, Edgington TS. Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells. J Clin Invest. 1980 Jan; 65(1):197-206. PMID: 6444222.
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    350. Cochrane CG, Griffin JH. Molecular assembly in the contact phase of the Hageman factor system. Am J Med. 1979 Oct; 67(4):657-64. PMID: 386794.
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    351. Seligsohn U, Osterud B, Brown SF, Griffin JH, Rapaport SI. Activation of human factor VII in plasma and in purified systems: roles of activated factor IX, kallikrein, and activated factor XII. J Clin Invest. 1979 Oct; 64(4):1056-65. PMID: 479368.
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    352. Griffin JH, Beretta G. Molecular mechanisms of surface-dependent activation of Hageman factor (Factor XII). Adv Exp Med Biol. 1979; 120B:39-51. PMID: 517240.
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    353. Wiggins RC, Cochrane CG, Griffin JH. Rabbit blood coagulation factor XI. Purification and properties. Thromb Res. 1979; 15(3-4):475-86. PMID: 494156.
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    354. Griffin JH, Cochrane CG. Recent advances in the understanding of contact activation reactions. Semin Thromb Hemost. 1979; 5(4):254-73. PMID: 386517.
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    355. Wiggins RC, Cochrane CG, Griffin JH. Rabbit blood coagulation factor XI. Mechanism of activation of rabbit Hageman factor (factor XII). Thromb Res. 1979; 15(3-4):487-95. PMID: 494157.
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    356. Seligsohn U, Osterud B, Griffin JH, Rapaport SI. Evidence for the participation of both activated factor XII and activated factor IX in cold-promoted activation of factor VII. Thromb Res. 1978 Dec; 13(6):1049-56. PMID: 749262.
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    357. Osterud B, Bouma BN, Griffin JH. Human blood coagulation factor IX. Purification, properties, and mechanism of activation by activated factor XI. J Biol Chem. 1978 Sep 10; 253(17):5946-51. PMID: 681330.
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    358. Griffin JH. Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). Proc Natl Acad Sci U S A. 1978 Apr; 75(4):1998-2002. PMID: 273926.
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    359. Revak SD, Cochrane CG, Bouma BN, Griffin JH. Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma. J Exp Med. 1978 Mar 01; 147(3):719-29. PMID: 632748.
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    360. Bouma BN, Griffin JH. Deficiency of factor XII-dependent plasminogen proactivator in prekallikrein-deficient plasma. J Lab Clin Med. 1978 Jan; 91(1):148-55. PMID: 73563.
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    361. Davis S, Furie BC, Griffin JH, Furie B, Willey R. Circulating inhibitors of blood coagulation associated with procainamide-induced lupus erythematosus. Am J Hematol. 1978; 4(4):401-7. PMID: 717399.
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    362. Convert O, Griffin JH, Di Bello C, Nicolas P, Cohen P. Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for the analysis of peptide hormone interactions with bovine neurophysin I using 13C nuclear magnetic resonance spectroscopy. Biochemistry. 1977 Nov 15; 16(23):5061-5. PMID: 562184.
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    363. Wiggins RC, Bouma BN, Cochrane CG, Griffin JH. Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4636-40. PMID: 270705.
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    364. Bouma BN, Griffin JH. Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII. J Biol Chem. 1977 Sep 25; 252(18):6432-7. PMID: 893417.
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    365. Griffin JH, DiBello C, Alazard R, Nicolas P, Cohen P. Carbon-13 nuclear magnetic resonance studies of the binding of selectively 13C-enriched oxytocins to the neurophypophyseal protein, bovine neurophysin II. Biochemistry. 1977 Sep 20; 16(19):4194-8. PMID: 561612.
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    366. Revak SD, Cochrane CG, Griffin JH. The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen. J Clin Invest. 1977 Jun; 59(6):1167-75. PMID: 864009.
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    367. Di Bello C, Griffin JH. Circular dichroism and absorbance properties of nitrotyrosyl chromophores in staphylococcal nuclease and in a model diketopiperazine. J Biol Chem. 1975 Feb 25; 250(4):1445-50. PMID: 234457.
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    368. Cohen P, Camier M, Wolff J, Alazard R, Cohen JS, Griffin JH. Studies of bovine neurophysin-neurohypophyseal hormone interactions. Ann N Y Acad Sci. 1975 Feb 21; 248:463-79. PMID: 235235.
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    369. Griffin JH, Furie B, Schechter AN. Application of nuclear magnetic resonance spectroscopy to proteins. Biochimie. 1975; 57(4):453-60. PMID: 1148335.
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    370. Alazard R, Cohen P, Cohen JS, Griffin JH. Interactions of bovine neurophysin II with oxytocin and (8-lysine) vasopressin. High resolution proton nuclear magnetic resonance spectroscopy studies. J Biol Chem. 1974 Nov 10; 249(21):6895-900. PMID: 4423570.
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    371. Griffin JH, Schechter AN, Cohen JS. Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme. Ann N Y Acad Sci. 1973 Dec 31; 222:693-708. PMID: 4522440.
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    372. Griffin JH, Alazard R, Cohen P. Complex formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region. Absorbance and circular dichroism difference spectroscopic studies. J Biol Chem. 1973 Dec 10; 248(23):7975-8. PMID: 4796247.
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    373. Griffin JH, Cohen JS, Schechter AN. The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119. Biochemistry. 1973 May 22; 12(11):2096-9. PMID: 4735881.
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    374. Griffin JH, Criddle RS. Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits. Biochemistry. 1970 Mar 03; 9(5):1195-205. PMID: 4313938.
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