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John Griffin

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0912
La Jolla CA 92093
Phone000-000-NULL
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    Collapse Research 
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    Regulation of Protein C Pathways
    NIH/NHLBI R01HL142975Jun 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
    NIH/NIAID U01AI133561Jun 5, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Human exomics genotyping-driven discovery and characterization of proteins related to clinical thrombosis, blood coagulation and thrombin generation
    NIH/NHLBI R01HL133728Sep 15, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Murine Protein C and Protein S Proof of Principle Research
    NIH/NHLBI R01HL104074Jan 1, 2011 - Jul 31, 2011
    Role: Principal Investigator
    Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    NIH/NHLBI RC1HL101034Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Drug Engineering of Transglutaminase 2 Inhibitors
    NIH/NIDDK R41DK081244Feb 1, 2009 - Jan 31, 2011
    Role: Principal Investigator
    Novel targets and agents to treat thrombotic disorders
    NIH/NHLBI R01HL078684Sep 24, 2004 - Aug 31, 2005
    Role: Principal Investigator
    Structure and Function of Protein C
    NIH/NHLBI R01HL052246Dec 1, 1994 - Nov 30, 2013
    Role: Principal Investigator
    STRUCTURE AND FUNCTION OF PROTEIN C
    NIH/NHLBI R37HL052246Dec 1, 1994 - Nov 30, 2004
    Role: Principal Investigator
    IMPROVED FUNCTIONS FOR RECEPTOR LIKE ANTIBIOTICS
    NIH/NIGMS R01GM051122May 1, 1994 - Aug 31, 1998
    Role: Principal Investigator
    NOVEL SEMISYNTHETIC DERIVATIVES OF VANCOMYCIN
    NIH/NIGMS R21GM051122May 1, 1994 - Apr 30, 1996
    Role: Principal Investigator
    Thrombus Formation and Antithrombotic Intervention
    NIH/NHLBI P01HL031950Apr 1, 1984 - Nov 30, 1999
    Role: Principal Investigator
    PROTEIN C--AN ANTITHROMBOTIC-PROFIBRINOLYTIC AGENT
    NIH/NHLBI R01HL024891Aug 1, 1982 - Jul 31, 1992
    Role: Principal Investigator
    Proteins of Coagulation Pathways
    NIH/NHLBI R01HL021544Jul 1, 1977 - Sep 14, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel Blood Coagulation Molecules: Skeletal Muscle Myosin and Cardiac Myosin. J Thromb Haemost. 2020 Sep 13. Deguchi H, Morla S, Griffin JH. PMID: 32920971.
      View in: PubMed   Mentions:    Fields:    
    2. An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms. Blood Adv. 2020 Aug 11; 4(15):3716-3727. von Drygalski A, Bhat V, Gale AJ, Averell PM, Cramer TJ, Elias DJ, Griffin JH, Mosnier LO. PMID: 32777068.
      View in: PubMed   Mentions:    Fields:    
    3. 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase. Stroke. 2020 Jul; 51(7):2236-2239. Mukherjee P, Lyden P, Fernández JA, Davis TP, Pryor KE, Zlokovic BV, Griffin JH. PMID: 32568648.
      View in: PubMed   Mentions:    Fields:    
    4. COVID-19 hypothesis: Activated protein C for therapy of virus-induced pathologic thromboinflammation. Res Pract Thromb Haemost. 2020 May; 4(4):506-509. Griffin JH, Lyden P. PMID: 32548551.
      View in: PubMed   Mentions:
    5. Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus. Blood. 2020 May 28; 135(22):1969-1982. Calzavarini S, Prince-Eladnani R, Saller F, Bologna L, Burnier L, Brisset AC, Quarroz C, Reina Caro MD, Ermolayev V, Matsumura Y, Fernández JA, Hackeng TM, Griffin JH, Angelillo-Scherrer A. PMID: 32276277.
      View in: PubMed   Mentions: 1     Fields:    
    6. Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation. Front Neurosci. 2020; 14:333. Kant R, Halder SK, Fernández JA, Griffin JH, Milner R. PMID: 32351356.
      View in: PubMed   Mentions:
    7. Novel exomic rare variants associated with venous thrombosis. Br J Haematol. 2020 Mar 30. Deguchi H, Shukla M, Hayat M, Torkamani A, Elias DJ, Griffin JH. PMID: 32232851.
      View in: PubMed   Mentions:    Fields:    
    8. FVIIa (Factor VIIa) Induces Biased Cytoprotective Signaling in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 (Arginine41) Site. Arterioscler Thromb Vasc Biol. 2020 05; 40(5):1275-1288. Kondreddy V, Pendurthi UR, Xu X, Griffin JH, Rao LVM. PMID: 32212848.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities. J Thromb Haemost. 2020 May; 18(5):1027-1038. Yamashita A, Zhang Y, Sanner MF, Griffin JH, Mosnier LO. PMID: 32017367.
      View in: PubMed   Mentions: 1     Fields:    
    10. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2020 04; 40(4):901-913. Zilberman-Rudenko J, Deguchi H, Shukla M, Oyama Y, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Eckle T, Griffin JH. PMID: 32102568.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Plasma skeletal muscle myosin phenotypes identified by immunoblotting are associated with pulmonary embolism occurrence in young adults. Thromb Res. 2020 05; 189:88-92. Deguchi TK, Deguchi H, Guo Z, Elias DJ, Griffin JH. PMID: 32192996.
      View in: PubMed   Mentions:    Fields:    
    12. Serum amyloid A4 is a procoagulant apolipoprotein that it is elevated in venous thrombosis patients. Res Pract Thromb Haemost. 2020 Feb; 4(2):217-223. Fernández JA, Deguchi H, Elias DJ, Griffin JH. PMID: 32110751.
      View in: PubMed   Mentions:
    13. Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin. Haematologica. 2020 Aug; 105(8):e424-e427. Heeb MJ, Fernández JA, Yamashita A, McDowell OR, Guo Z, Mosnier LO, Deguchi H, Griffin JH. PMID: 31857364.
      View in: PubMed   Mentions:    Fields:    
    14. Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects. Shock. 2019 11; 52(5):554-555. Coleman JR, Moore EE, Zilberman-Rudenko J, Samuels JM, Cohen MJ, Silliman CC, Banerjee A, Sauaia A, Griffin JH, Deguchi H. PMID: 31613865.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    15. Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombin activation. J Biol Chem. 2019 10 11; 294(41):15176-15181. Deguchi H, Guo Z, Hayat M, Pflimlin E, Lear S, Shen W, Griffin JH. PMID: 31481465.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis. Blood. 2019 10 03; 134(14):1119-1131. Müller-Calleja N, Hollerbach A, Ritter S, Pedrosa DG, Strand D, Graf C, Reinhardt C, Strand S, Poncelet P, Griffin JH, Lackner KJ, Ruf W. PMID: 31434703.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells. Blood. 2019 08 29; 134(9):776-781. Sinha RK, Flynn R, Zaiken M, Paz K, Gavin AL, Nemazee D, Fernández JA, Xu X, Griffin JH, Blazar BR. PMID: 31243040.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Neuroprotection and vasculoprotection using genetically targeted protease-ligands. Brain Res. 2019 07 15; 1715:13-20. Rajput PS, Lamb JA, Fernández JÁ, Bai J, Pereira BR, Lei IF, Leung J, Griffin JH, Lyden PD. PMID: 30880117.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. PMID: 30647119.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 01; 85(1):125-136. Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV. PMID: 30450637.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    21. Design of a DNA-Programmed Plasminogen Activator. J Am Chem Soc. 2018 11 14; 140(45):15516-15524. Mukherjee P, Leman LJ, Griffin JH, Ghadiri MR. PMID: 30347143.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Activated protein C, protease activated receptor 1, and neuroprotection. Blood. 2018 07 12; 132(2):159-169. Griffin JH, Zlokovic BV, Mosnier LO. PMID: 29866816.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 06 01; 73(6):1586-1594. Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. PMID: 29514266.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Regulation of immune cell signaling by activated protein C. J Leukoc Biol. 2018 Mar 30. Healy LD, Rigg RA, Griffin JH, McCarty OJT. PMID: 29601101.
      View in: PubMed   Mentions: 2     Fields:    
    25. a2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:a2M Levels Are Associated with Venous Thromboembolism. Thromb Haemost. 2018 04; 118(4):630-638. Martos L, Ramón LA, Oto J, Fernández-Pardo Á, Bonanad S, Cid AR, Gruber A, Griffin JH, España F, Navarro S, Medina P. PMID: 29448296.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    26. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 05; 36(5):796-806. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. PMID: 29396891.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PMID: 29343482.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    28. Targeting anticoagulant protein S to improve hemostasis in hemophilia. Blood. 2018 03 22; 131(12):1360-1371. Prince R, Bologna L, Manetti M, Melchiorre D, Rosa I, Dewarrat N, Suardi S, Amini P, Fernández JA, Burnier L, Quarroz C, Reina Caro MD, Matsumura Y, Kremer Hovinga JA, Griffin JH, Simon HU, Ibba-Manneschi L, Saller F, Calzavarini S, Angelillo-Scherrer A. PMID: 29317453.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    29. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. PMID: 28923278.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    30. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. Blood. 2017 12 14; 130(24):2664-2677. Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K. PMID: 28882883.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    31. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S. Blood Adv. 2017 Aug 08; 1(18):1423-1426. Fernández JA, Xu X, Sinha RK, Mosnier LO, Sanner MF, Griffin JH. PMID: 29296783.
      View in: PubMed   Mentions: 1     Fields:    
    32. Low level of the plasma sphingolipid, glucosylceramide, is associated with thrombotic diseases. Res Pract Thromb Haemost. 2017 Jul; 1(1):33-40. Deguchi H, Navarro S, Payne AB, Elias DJ, Dowling NF, Austin HD, España F, Medina P, Hooper WC, Griffin JH. PMID: 29202121.
      View in: PubMed   Mentions:
    33. Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk. Res Pract Thromb Haemost. 2017 Jul; 1(1):93-102. Deguchi H, Elias DJ, Griffin JH. PMID: 29082360.
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    34. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017 05 26; 292(21):8616-8629. Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin JH, McCarty OJT. PMID: 28408624.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. PMID: 27758767.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    36. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. PMID: 27548576.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    37. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood. 2016 10 06; 128(14):1870-1878. Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJT, Cohen MJ, Griffin JH. PMID: 27421960.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    38. Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C. Exp Neurol. 2016 09; 283(Pt A):396-403. Burnier L, Boroujerdi A, Fernández JA, Welser-Alves JV, Griffin JH, Milner R. PMID: 27412766.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    39. Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism. J Atheroscler Thromb. 2016 Oct 01; 23(10):1159-1167. Deguchi H, Banerjee Y, Elias DJ, Griffin JH. PMID: 27169917.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thromb Res. 2016 May; 141 Suppl 2:S62-4. Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. PMID: 27207428.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis. Thromb Res. 2016 Jul; 143:17-21. Alsultan A, Gale AJ, Kurban K, Khalifah M, Albadr FB, Griffin JH. PMID: 27172833.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding. Pharm Res. 2016 06; 33(6):1517-26. Gale AJ, Bhat V, Pellequer JL, Griffin JH, Mosnier LO, Von Drygalski A. PMID: 26960296.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    43. Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):518-24. Sinha RK, Yang XV, Fernández JA, Xu X, Mosnier LO, Griffin JH. PMID: 26800564.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thromb Haemost. 2016 Mar; 115(3):551-61. Bhat V, von Drygalski A, Gale AJ, Griffin JH, Mosnier LO. PMID: 26466980.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    45. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood. 2015 Nov 19; 126(21):2415-23. Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H. PMID: 26341257.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344. Amar AP, Griffin JH, Zlokovic BV. PMID: 26388732.
      View in: PubMed   Mentions:
    47. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex. PLoS One. 2015; 10(8):e0135025. Yegneswaran S, Banerjee Y, Fernández JA, Deguchi H, Griffin JH. PMID: 26263376.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    48. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015 Nov 05; 126(19):2247-53. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, Miyata T. PMID: 26251307.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    49. Inhibition of thrombin generation in human plasma by phospholipid transfer protein. Thromb J. 2015; 13:24. Deguchi H, Wolfbauer G, Cheung MC, Banerjee Y, Elias DJ, Fernández JA, Albers JJ, Griffin JH. PMID: 26185485.
      View in: PubMed   Mentions:
    50. Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data. Blood. 2015 Sep 24; 126(13):1595-600. Deguchi H, Banerjee Y, Trauger S, Siuzdak G, Kalisiak E, Fernández JA, Hoang L, Tran M, Yegneswaran S, Elias DJ, Griffin JH. PMID: 26175037.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. Activated protein C: biased for translation. Blood. 2015 May 07; 125(19):2898-907. Griffin JH, Zlokovic BV, Mosnier LO. PMID: 25824691.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    52. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30; 125(18):2845-54. Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H. PMID: 25733582.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    53. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):570-2. Fernandez JA, Deguchi H, Banka CL, Witztum JL, Griffin JH. PMID: 25550205.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    54. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost. 2014 Nov; 112(5):883-92. Mosnier LO, Zlokovic BV, Griffin JH. PMID: 25230930.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    55. An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C. PLoS One. 2014; 9(8):e104304. von Drygalski A, Bhat V, Gale AJ, Burnier L, Cramer TJ, Griffin JH, Mosnier LO. PMID: 25127130.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    56. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. PMID: 24591593.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    57. Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids. Br J Haematol. 2014 May; 165(3):409-12. Deguchi H, Elias DJ, Trauger S, Zhang HM, Kalisiak E, Siuzdak G, Griffin JH. PMID: 24450944.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution. J Thromb Haemost. 2014 Jan; 12(1):90-2. Deguchi H, Elias DJ, Griffin JH. PMID: 24406066.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    59. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant. J Thromb Haemost. 2014; 12(3):363-72. von Drygalski A, Cramer TJ, Bhat V, Griffin JH, Gale AJ, Mosnier LO. PMID: 24818532.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    60. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. J Thromb Haemost. 2013 Nov; 11(11):2059-62. Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. PMID: 24034518.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    61. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. PMID: 24159062.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    62. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation. Thromb Haemost. 2013 Aug; 110(2):275-82. Heeb MJ, Mesters RM, Fernández JA, Hackeng TM, Nakasone RK, Griffin JH. PMID: 23892573.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    63. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013 Apr 03; 33(14):6181-90. Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. PMID: 23554499.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    64. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. PMID: 23541526.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    65. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res. 2013 Apr 24; 1507:97-104. Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. PMID: 23438513.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    66. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):769-76. von Drygalski A, Furlan-Freguia C, Ruf W, Griffin JH, Mosnier LO. PMID: 23393392.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    67. Antibody SPC-54 provides acute in vivo blockage of the murine protein C system. Blood Cells Mol Dis. 2013 Apr; 50(4):252-8. Burnier L, Fernández JA, Griffin JH. PMID: 23385154.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    68. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des. 2013; 19(42):7479-85. Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. PMID: 24372304.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    69. Elevated serum amyloid A is associated with venous thromboembolism. Thromb Haemost. 2013 Feb; 109(2):358-9. Deguchi H, Elias DJ, Navarro S, España F, Griffin JH. PMID: 23255027.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    70. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood. 2012 Dec 20; 120(26):5237-46. Mosnier LO, Sinha RK, Burnier L, Bouwens EA, Griffin JH. PMID: 23149848.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    71. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. J Am Chem Soc. 2012 Nov 28; 134(47):19318-21. Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM. PMID: 23066897.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    72. Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux. Thromb Haemost. 2012 Nov; 108(5):981-91. von Drygalski A, Furlan-Freguia C, Mosnier LO, Yegneswaran S, Ruf W, Griffin JH. PMID: 23052565.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    73. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke. 2012 Sep; 43(9):2444-9. Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. PMID: 22811462.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    74. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med. 2012 Jul; 18(7):1123-9. Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M. PMID: 22729286.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    75. Protein C anticoagulant and cytoprotective pathways. Int J Hematol. 2012 Apr; 95(4):333-45. Griffin JH, Zlokovic BV, Mosnier LO. PMID: 22477541.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    76. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22. Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. PMID: 22632606.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    77. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood. 2012 Jan 19; 119(3):874-83. Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B. PMID: 22117049.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    78. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2509-17. Raife TJ, Dwyre DM, Stevens JW, Erger RA, Leo L, Wilson KM, Fernández JA, Wilder J, Kim HS, Griffin JH, Maeda N, Lentz SR. PMID: 21885846.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    79. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism. Thromb Res. 2012 Apr; 129(4):502-7. Hansen JB, Fernández JA, Borch KH, Griffin JH, Brox JH, Braekkan SK. PMID: 21777953.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    80. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 01; 21(13):4108-14. Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, Griffin JH. PMID: 21632247.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    81. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 2011 Apr; 34(4):198-209. Zlokovic BV, Griffin JH. PMID: 21353711.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    82. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13. Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21291561.
      View in: PubMed   Mentions: 9     Fields:    
    83. Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):632-41. Bir N, Lafargue M, Howard M, Goolaerts A, Roux J, Carles M, Cohen MJ, Iles KE, Fernández JA, Griffin JH, Pittet JF. PMID: 21257925.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    84. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorg Med Chem Lett. 2011 May 01; 21(9):2692-6. Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH. PMID: 21215619.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    85. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21084607.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    86. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest. 2010 Sep; 120(9):3167-78. Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H. PMID: 20714108.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    87. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va. Pathophysiol Haemost Thromb. 2010; 37(1):17-23. Cramer TJ, Griffin JH, Gale AJ. PMID: 20501981.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    88. Association of Apo(a)isoform size with dyslipoproteinemia in male venous thrombosis patients. Clin Chim Acta. 2010 Sep 06; 411(17-18):1279-83. Cheung MC, Albers JJ, Kennedy H, Deguchi H, Elias DJ, Averell PM, Griffin JH, Marcovina SM. PMID: 20488173.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    89. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. PMID: 19841542.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    90. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31. Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. PMID: 19815836.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    91. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009 Sep 10; 114(11):2307-14. Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernández JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. PMID: 19567881.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    92. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost. 2009 Apr; 101(4):724-33. Schuepbach RA, Feistritzer C, Fernández JA, Griffin JH, Riewald M. PMID: 19350118.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    93. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci. 2009 Mar; 29(6):1119-30. Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. PMID: 19302148.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    94. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood. 2009 Jun 04; 113(23):5970-8. Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernández JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin JH. PMID: 19244160.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    95. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J. 2009 Jul; 23(7):2244-53. Heeb MJ, Prashun D, Griffin JH, Bouma BN. PMID: 19244162.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    96. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem. 2009 Apr; 109(1):116-24. Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. PMID: 19166505.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    97. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 2009 Mar 19; 113(12):2859-66. Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. PMID: 19141861.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    98. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C. Thromb Haemost. 2009 Jan; 101(1):55-61. Yegneswaran S, Nguyen PM, Gale AJ, Griffin JH. PMID: 19132189.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    99. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):274-9. Yang XV, Banerjee Y, Fernández JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH. PMID: 19116273.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    100. Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology. Biochim Biophys Acta. 2009 Mar; 1791(3):206-11. Cheung MC, Wolfbauer G, Deguchi H, Fernández JA, Griffin JH, Albers JJ. PMID: 19162221.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    101. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. PMID: 19036971.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    102. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. J Biol Chem. 2008 Nov 28; 283(48):33046-52. Yegneswaran S, Hackeng TM, Dawson PE, Griffin JH. PMID: 18784085.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    103. Elevated plasma fibronectin levels associated with venous thromboembolism. Thromb Haemost. 2008 Aug; 100(2):224-8. Pecheniuk NM, Elias DJ, Deguchi H, Averell PM, Griffin JH. PMID: 18690341.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    104. Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations. J Thromb Haemost. 2008 Jul; 6(7):1235-7. Heeb MJ, Gandrille S, Fernandez JA, Griffin JH, Fedullo PF. PMID: 18433462.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    105. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. J Thromb Haemost. 2008 Jun; 6(6):995-1002. White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernández JA, Griffin JH, Gruber A, McCarty OJ. PMID: 18489431.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    106. Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry. Thromb Haemost. 2008 Feb; 99(2):453-5. Pecheniuk NM, Elias DJ, Xu X, Griffin JH. PMID: 18278202.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    107. Plasma cholesteryl ester transfer protein and blood coagulability. Thromb Haemost. 2007 Dec; 98(6):1160-4. Deguchi H, Fernández JA, Griffin JH. PMID: 18064308.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    108. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007 Oct 01; 204(10):2439-48. Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H. PMID: 17893198.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    109. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem. 2007 Nov 09; 282(45):33022-33. Mosnier LO, Yang XV, Griffin JH. PMID: 17872949.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    110. Factor Va residues 311-325 represent an activated protein C binding region. J Biol Chem. 2007 Sep 28; 282(39):28353-61. Yegneswaran S, Kojima Y, Nguyen PM, Gale AJ, Heeb MJ, Griffin JH. PMID: 17646160.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    111. Activated protein C. J Thromb Haemost. 2007 Jul; 5 Suppl 1:73-80. Griffin JH, Fernández JA, Gale AJ, Mosnier LO. PMID: 17635713.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    112. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. J Biol Chem. 2007 Jul 27; 282(30):21848-55. Gale AJ, Yegneswaran S, Xu X, Pellequer JL, Griffin JH. PMID: 17553804.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    113. High-density lipoprotein and the risk of recurrent venous thromboembolism. Circulation. 2007 Mar 27; 115(12):1609-14. Eichinger S, Pecheniuk NM, Hron G, Deguchi H, Schemper M, Kyrle PA, Griffin JH. PMID: 17372172.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    114. Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood. 2007 May 01; 109(9):3733-40. Gruber A, Marzec UM, Bush L, Di Cera E, Fernández JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR. PMID: 17227834.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    115. Activation of protein C and hemodynamic recovery after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2007 Jan; 133(1):44-51. Raivio P, Fernández JA, Kuitunen A, Griffin JH, Lassila R, Petäjä J. PMID: 17198779.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    116. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. Mosnier LO, Zlokovic BV, Griffin JH. PMID: 17110453.
      View in: PubMed   Mentions: 275     Fields:    Translation:HumansAnimals
    117. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. PMID: 17072311.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    118. Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays. J Thromb Haemost. 2007 Jan; 5(1):102-8. Radtke KP, Griffin JH, Riceberg J, Gale AJ. PMID: 17059431.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    119. Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males. J Thromb Haemost. 2006 Sep; 4(9):2080-2. Pecheniuk NM, Deguchi H, Elias DJ, Xu X, Griffin JH. PMID: 16961620.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    120. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities. Front Biosci. 2006 Sep 01; 11:2381-99. Mosnier LO, Griffin JH. PMID: 16720321.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    121. A novel ELISA for mouse activated protein C in plasma. J Immunol Methods. 2006 Jul 31; 314(1-2):174-81. Fernández JA, Lentz SR, Dwyre DM, Griffin JH. PMID: 16828789.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    122. Endothelial and antithrombotic actions of HDL. Circ Res. 2006 Jun 09; 98(11):1352-64. Mineo C, Deguchi H, Griffin JH, Shaul PW. PMID: 16763172.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimals
    123. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants. J Thromb Haemost. 2006 Jun; 4(6):1315-22. Gale AJ, Radtke KP, Cunningham MA, Chamberlain D, Pellequer JL, Griffin JH. PMID: 16706977.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    124. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem. 2006 Jul 21; 281(29):20077-84. Feistritzer C, Schuepbach RA, Mosnier LO, Bush LA, Di Cera E, Griffin JH, Riewald M. PMID: 16709569.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    125. Is adiponectin implicated in venous thromboembolism? J Thromb Haemost. 2006 May; 4(5):1151-2. Fernández JA, Pecheniuk NM, Deguchi H, Elias DJ, Griffin JH. PMID: 16689775.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    126. Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects. Cardiovasc Drugs Ther. 2006 Apr; 20(2):113-21. Fernández JA, Vento AE, Jormalainen M, Griffin JH, Pesonen E, Syrjälä M, Repo H, Jansson SE, Rämö OJ, Petäjä J. PMID: 16761191.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    127. The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 16464623.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    128. Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates. J Thromb Haemost. 2006 Feb; 4(2):392-7. Gruber A, Fernández JA, Bush L, Marzec U, Griffin JH, Hanson SR, DI Cera E. PMID: 16420571.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    129. Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis. Crit Care. 2006 Feb; 10(1):R16. Lindstrom O, Kylanpaa L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petaja J. PMID: 16420659.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    130. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation. Crit Care Med. 2006 Feb; 34(2):426-32. Ilmakunnas M, Pesonen EJ, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin JH, Repo H, Siitonen S, Petäjä J. PMID: 16424724.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    131. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates. Br J Haematol. 2006 Jan; 132(2):197-203. Tanaka KA, Fernández JA, Marzec UM, Kelly AB, Mohri M, Griffin JH, Hanson SR, Gruber A. PMID: 16398653.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    132. Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7. Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. PMID: 16130108.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    133. Activated protein C reduces graft neutrophil activation in clinical renal transplantation. Am J Transplant. 2005 Sep; 5(9):2204-12. Turunen AJ, Fernández JA, Lindgren L, Salmela KT, Kyllönen LE, Mäkisalo H, Griffin JH, Siitonen SM, Petäjä J, Pesonen EJ. PMID: 16095499.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    134. High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. Circulation. 2005 Aug 09; 112(6):893-9. Deguchi H, Pecheniuk NM, Elias DJ, Averell PM, Griffin JH. PMID: 16087810.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    135. Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide. J Thromb Haemost. 2005 May; 3(5):935-8. Deguchi H, Bouma BN, Middeldorp S, Lee YM, Griffin JH. PMID: 15869587.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    136. Cholesterol enhances phospholipid-dependent activated protein C anticoagulant activity. J Thromb Haemost. 2005 Feb; 3(2):340-5. Pecheniuk NM, Deguchi H, Griffin JH. PMID: 15670041.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    137. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Ann Rheum Dis. 2004 Nov; 63(11):1445-9. Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livneh A, Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. PMID: 15479893.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    138. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes. 2004 Nov; 53(11):2804-14. Contreras JL, Eckstein C, Smyth CA, Bilbao G, Vilatoba M, Ringland SE, Young C, Thompson JA, Fernández JA, Griffin JH, Eckhoff DE. PMID: 15504960.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    139. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec; 10(12):1379-83. Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. PMID: 15516929.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    140. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex. J Biol Chem. 2004 Nov 19; 279(47):49019-25. Yegneswaran S, Mesters RM, Fernández JA, Griffin JH. PMID: 15331602.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    141. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood. 2004 Sep 15; 104(6):1740-4. Mosnier LO, Gale AJ, Yegneswaran S, Griffin JH. PMID: 15178575.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    142. Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53. Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 15118526.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    143. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. PMID: 14980205.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    144. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va. Proteins. 2004 Feb 15; 54(3):433-41. Gale AJ, Griffin JH. PMID: 14747992.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    145. Sphingolipids as bioactive regulators of thrombin generation. J Biol Chem. 2004 Mar 26; 279(13):12036-42. Deguchi H, Yegneswaran S, Griffin JH. PMID: 14722105.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    146. Enantiotracin. Bioorg Med Chem Lett. 2003 Jul 07; 13(13):2239-40. McDougal PG, Griffin JH. PMID: 12798342.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    147. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J. 2003 Jul 01; 373(Pt 1):65-70. Mosnier LO, Griffin JH. PMID: 12683950.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    148. Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7830-5. Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R. PMID: 12808148.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    149. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. J Biol Chem. 2003 Aug 29; 278(35):33312-8. Yegneswaran S, Mesters RM, Griffin JH. PMID: 12805370.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    150. Multivalent drug design. Synthesis and in vitro analysis of an array of vancomycin dimers. J Am Chem Soc. 2003 May 28; 125(21):6517-31. Griffin JH, Linsell MS, Nodwell MB, Chen Q, Pace JL, Quast KL, Krause KM, Farrington L, Wu TX, Higgins DL, Jenkins TE, Christensen BG, Judice JK. PMID: 12785792.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    151. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. PMID: 12737945.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    152. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6. Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. PMID: 12665496.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    153. Activation of protein C during reperfusion in clinical liver transplantation. Transplantation. 2003 Feb 27; 75(4):467-72. Ilmakunnas M, Petäjä J, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin JH, Jansson SE, Repo H, Pesonen EJ. PMID: 12605111.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    154. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood. 2003 Jul 01; 102(1):146-51. Slungaard A, Fernandez JA, Griffin JH, Key NS, Long JR, Piegors DJ, Lentz SR. PMID: 12609838.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    155. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801. Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. PMID: 12586611.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    156. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. PMID: 12563316.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    157. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles. J Biol Chem. 2003 Apr 25; 278(17):14614-21. Yegneswaran S, Deguchi H, Griffin JH. PMID: 12560338.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    158. Coagulation pathways in atherothrombosis. Trends Cardiovasc Med. 2002 Oct; 12(7):317-24. Khrenov AV, Ananyeva NM, Griffin JH, Saenko EL. PMID: 12458095.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    159. Effect of hyperhomocysteinemia on protein C activation and activity. Blood. 2002 Sep 15; 100(6):2108-12. Lentz SR, Piegors DJ, Fernández JA, Erger RA, Arning E, Malinow MR, Griffin JH, Bottiglieri T, Haynes WG, Heistad DD. PMID: 12200374.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    160. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C. Protein Sci. 2002 Sep; 11(9):2091-101. Gale AJ, Xu X, Pellequer JL, Getzoff ED, Griffin JH. PMID: 12192065.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    161. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender. Blood Cells Mol Dis. 2002 Sep-Oct; 29(2):139-44. Heeb MJ, Paganini-Hill A, Griffin JH, Fisher M. PMID: 12490280.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    162. Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements. Blood Cells Mol Dis. 2002 Sep-Oct; 29(2):190-9. Heeb MJ, Griffin JH. PMID: 12490286.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    163. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation. 2002 Aug 13; 106(7):842-6. Lentz SR, Miller FJ, Piegors DJ, Erger RA, Fernández JA, Griffin JH, Heistad DD. PMID: 12176958.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    164. Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors. Blood. 2002 Dec 01; 100(12):4232-3. Simmelink MJ, de Groot PG, Derksen RH, Fernandez JA, Griffin JH. PMID: 12393585.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    165. Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes; the GUSTO-IIb haemostasis substudy. Eur Heart J. 2002 Aug; 23(15):1202-12. Kottke-Marchant K, Bahit MC, Granger CB, Zoldhelyi P, Ardissino D, Brooks L, Griffin JH, Potthoff RF, Van de Werf F, Califf RM, Topol EJ. PMID: 12127922.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    166. Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis. Biochemistry. 2002 Jul 02; 41(26):8238-44. Wu TK, Griffin JH. PMID: 12081472.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    167. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. Griffin JH, Zlokovic B, Fernández JA. PMID: 12124682.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    168. Protein C pathway impairment in nonsymptomatic cigarette smokers. Blood Cells Mol Dis. 2002 Jul-Aug; 29(1):73-82. Fernández JA, Gruber A, Heeb MJ, Griffin JH. PMID: 12482406.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    169. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C. J Biol Chem. 2002 Aug 09; 277(32):28836-40. Gale AJ, Tsavaler A, Griffin JH. PMID: 12063259.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    170. Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II. Br J Haematol. 2002 Jun; 117(3):676-84. Simmelink MJ, Fernández JA, Derksen RH, Griffin JH, de Groot PG. PMID: 12028041.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    171. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe. Chem Biol. 2002 Apr; 9(4):485-94. Yegneswaran S, Fernández JA, Griffin JH, Dawson PE. PMID: 11983337.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    172. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S. J Biol Chem. 2002 Mar 15; 277(11):8861-5. Deguchi H, Fernández JA, Griffin JH. PMID: 11741960.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    173. Plasma lipoproteins, hemostasis and thrombosis. Thromb Haemost. 2001 Jul; 86(1):386-94. Griffin JH, Fernández JA, Deguchi H. PMID: 11487028.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    174. Activated protein C and inflammation in human myocardium after heart surgery. Am J Hematol. 2001 Jul; 67(3):210-2. Petäjä J, Pesonen E, Fernández JA, Griffin JH, Repo H, Jansson SE, Vento AE, Rämö OJ. PMID: 11391722.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    175. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. PMID: 11282913.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    176. Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors. Antimicrob Agents Chemother. 2001 Apr; 45(4):1210-5. Buckner FS, Griffin JH, Wilson AJ, Van Voorhis WC. PMID: 11257036.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    177. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway. Blood. 2001 Apr 01; 97(7):1907-14. Deguchi H, Fernández JA, Pabinger I, Heit JA, Griffin JH. PMID: 11264150.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    178. American College of Medical Genetics consensus statement on factor V Leiden mutation testing. Genet Med. 2001 Mar-Apr; 3(2):139-48. Grody WW, Griffin JH, Taylor AK, Korf BR, Heit JA. PMID: 11280951.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    179. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation. Thromb Haemost. 2001 Feb; 85(2):274-9. Rintelen C, Yegneswaran S, Griffin JH. PMID: 11246547.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    180. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14074-8. Hackeng TM, Fernández JA, Dawson PE, Kent SB, Griffin JH. PMID: 11106381.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    181. Three-dimensional model of coagulation factor Va bound to activated protein C. Thromb Haemost. 2000 Nov; 84(5):849-57. Pellequer JL, Gale AJ, Getzoff ED, Griffin JH. PMID: 11127867.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    182. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S. Biochem J. 2000 Aug 01; 349 Pt 3:757-64. Hackeng TM, Yegneswaran S, Johnson AE, Griffin JH. PMID: 10903136.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    183. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites. Blood. 2000 Jul 15; 96(2):585-93. Gale AJ, Heeb MJ, Griffin JH. PMID: 10887122.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    184. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications. Crit Care Med. 2000 Jul; 28(7):2209-16. Mesters RM, Helterbrand J, Utterback BG, Yan B, Chao YB, Fernandez JA, Griffin JH, Hartman DL. PMID: 10921542.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    185. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage. J Biol Chem. 2000 Apr 28; 275(17):12410-5. Marx PF, Hackeng TM, Dawson PE, Griffin JH, Meijers JC, Bouma BN. PMID: 10777524.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    186. Cardiolipin enhances protein C pathway anticoagulant activity. Blood Cells Mol Dis. 2000 Apr; 26(2):115-23. Fernández JA, Kojima K, Petäjä J, Hackeng TM, Griffin JH. PMID: 10753602.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    187. Cardiolipin is a normal component of human plasma lipoproteins. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1743-8. Deguchi H, Fernandez JA, Hackeng TM, Banka CL, Griffin JH. PMID: 10677528.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    188. Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII. Thromb Haemost. 2000 Jan; 83(1):78-85. Gale AJ, Pellequer JL, Getzoff ED, Griffin JH. PMID: 10669159.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    189. Causes of thrombophilia yet to be discovered: a personal view. Haemostasis. 2000; 30 Suppl 2:26-33. Griffin JH, Deguchi H, Fernandez JA. PMID: 11251338.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    190. C-terminal residues 621-635 of protein S are essential for binding to factor Va. J Biol Chem. 1999 Dec 17; 274(51):36187-92. Heeb MJ, Kojima Y, Rosing J, Tans G, Griffin JH. PMID: 10593904.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    191. Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation. Thromb Haemost. 1999 Dec; 82(6):1703-8. Bouma BN, Mosnier LO, Meijers JC, Griffin JH. PMID: 10613658.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    192. Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C. Thromb Haemost. 1999 Nov; 82(5):1462-8. Fernández JA, Petäjä J, Griffin JH. PMID: 10595639.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    193. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. PMID: 10559029.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    194. Cardiopulmonary bypass and activation of antithrombotic plasma protein C. J Thorac Cardiovasc Surg. 1999 Sep; 118(3):422-9; discussion 429-31. Petäjä J, Pesonen E, Fernández JA, Vento AE, Rämö OJ, Griffin JH. PMID: 10469954.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    195. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10068-73. Hackeng TM, Griffin JH, Dawson PE. PMID: 10468563.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    196. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C. Blood. 1999 Aug 01; 94(3):895-901. Zivelin A, Gitel S, Griffin JH, Xu X, Fernandez JA, Martinowitz U, Cohen Y, Halkin H, Seligsohn U, Inbal A. PMID: 10419879.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    197. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1744-50. Lentz SR, Fernández JA, Griffin JH, Piegors DJ, Erger RA, Malinow MR, Heistad DD. PMID: 10397693.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    198. Two multiplex PCR-based DNA assays for the thrombosis risk factors prothrombin G20210A and coagulation factor V G1691A polymorphisms. Thromb Res. 1999 Mar 15; 93(6):265-9. Xu X, Bauer KA, Griffin JH. PMID: 10093967.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    199. Brain-specific protein C activation during carotid artery occlusion in humans. Stroke. 1999 Mar; 30(3):542-5. Macko RF, Killewich LA, Fernández JA, Cox DK, Gruber A, Griffin JH. PMID: 10066849.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    200. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C. J Clin Invest. 1999 Jan; 103(2):219-27. Griffin JH, Kojima K, Banka CL, Curtiss LK, Fernández JA. PMID: 9916134.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    201. Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains. Blood Cells Mol Dis. 1998 Dec; 24(4):448-61. Pellequer JL, Gale AJ, Griffin JH, Getzoff ED. PMID: 9880241.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    202. Upregulation of the antithrombotic protein C pathway at birth. Pediatr Hematol Oncol. 1998 Nov-Dec; 15(6):489-99. Petäjä J, Fernández JA, Fellman V, Griffin JH. PMID: 9842642.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    203. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa. J Biol Chem. 1998 Sep 11; 273(37):23764-72. Mounier CM, Hackeng TM, Schaeffer F, Faure G, Bon C, Griffin JH. PMID: 9726985.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    204. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module. Biopolymers. 1998 Aug; 46(2):53-63. Hackeng TM, Dawson PE, Kent SB, Griffin JH. PMID: 9664841.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    205. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va. J Biol Chem. 1998 Jun 12; 273(24):14900-5. Kojima Y, Heeb MJ, Gale AJ, Hackeng TM, Griffin JH. PMID: 9614093.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    206. Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein. Blood Cells Mol Dis. 1998 Jun; 24(2):101-12; discussion 113. Fernández JA, Griffin JH, Chang GT, Stam J, Reitsma PH, Bertina RM, Bouma BN. PMID: 9628846.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    207. Circulating activated protein C in subjects with heterozygous Gln506-factor V. Haemostasis. 1998 Jan-Feb; 28(1):31-6. Petäjä J, Hakala L, Rasi V, Griffin JH. PMID: 9885368.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    208. Activated protein C resistance: What have we learned now that the dust has settled? Ann Med. 1997 Dec; 29(6):469-72. Petäjä JM, Griffin JH. PMID: 9562511.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    209. A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11563-6. Wang L, Zoppè M, Hackeng TM, Griffin JH, Lee KF, Verma IM. PMID: 9326649.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    210. Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11484-9. Smiley ST, Boyer SN, Heeb MJ, Griffin JH, Grusby MJ. PMID: 9326636.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    211. Activated protein C correlates inversely with thrombin levels in resting healthy individuals. Am J Hematol. 1997 Sep; 56(1):29-31. Fernández JA, Petäjä J, Gruber A, Griffin JH. PMID: 9298864.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    212. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7845-50. Hackeng TM, Mounier CM, Bon C, Dawson PE, Griffin JH, Kent SB. PMID: 9223275.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    213. The carbohydrate moiety of factor V modulates inactivation by activated protein C. Blood. 1997 Jun 15; 89(12):4348-54. Fernández JA, Hackeng TM, Kojima K, Griffin JH. PMID: 9192757.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    214. Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C. J Clin Invest. 1997 Jun 01; 99(11):2655-63. Petäjä J, Fernández JA, Gruber A, Griffin JH. PMID: 9169495.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    215. Potent blood coagulant activity of human semen due to prostasome-bound tissue factor. Biol Reprod. 1997 Mar; 56(3):757-63. Fernández JA, Heeb MJ, Radtke KP, Griffin JH. PMID: 9047022.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    216. A single genetic origin for a common Caucasian risk factor for venous thrombosis. Blood. 1997 Jan 15; 89(2):397-402. Zivelin A, Griffin JH, Xu X, Pabinger I, Samama M, Conard J, Brenner B, Eldor A, Seligsohn U. PMID: 9002940.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    217. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va. Protein Sci. 1997 Jan; 6(1):132-40. Gale AJ, Sun X, Heeb MJ, Griffin JH. PMID: 9007985.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    218. Impairments of the protein C system and fibrinolysis in infection-associated stroke. Stroke. 1996 Nov; 27(11):2005-11. Macko RF, Ameriso SF, Gruber A, Griffin JH, Fernandez JA, Barndt R, Quismorio FP, Weiner JM, Fisher M. PMID: 8898806.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    219. Central venous thrombosis after cardiac operations in children. J Thorac Cardiovasc Surg. 1996 Oct; 112(4):883-9. Petäjä J, Lundström U, Sairanen H, Marttinen E, Griffin JH. PMID: 8873713.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    220. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va. Protein Sci. 1996 Sep; 5(9):1883-9. Heeb MJ, Kojima Y, Hackeng TM, Griffin JH. PMID: 8880912.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    221. Steric and Electronic Effects, Enantiospecificity, and Reactive Orientation in DNA Binding/Cleaving by Substituted Derivatives of [SalenMn(III)](+). Inorg Chem. 1996 Aug 14; 35(17):4837-4847. Gravert DJ, Griffin JH. PMID: 11666683.
      View in: PubMed   Mentions: 3     Fields:    
    222. Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis. Blood. 1996 Aug 01; 88(3):877-80. Brenner B, Zivelin A, Lanir N, Greengard JS, Griffin JH, Seligsohn U. PMID: 8704244.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    223. Activated protein C resistance in ischemic stroke not due to factor V arginine506-->glutamine mutation. Stroke. 1996 Jul; 27(7):1163-6. Fisher M, Fernandez JA, Ameriso SF, Xie D, Gruber A, Paganini-Hill A, Griffin JH. PMID: 8685921.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    224. Solid-Phase Total Synthesis of Bacitracin A. J Org Chem. 1996 Jun 14; 61(12):3983-3986. Lee J, Griffin JH, Nicas TI. PMID: 11667271.
      View in: PubMed   Mentions: 3     Fields:    
    225. Inhibition of 2,3-oxidosqualene-lanosterol cyclase in Candida albicans by pyridinium ion-based inhibitors. Antimicrob Agents Chemother. 1996 Apr; 40(4):1044-7. Goldman RC, Zakula D, Capobianco JO, Sharpe BA, Griffin JH. PMID: 8849227.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    226. Quantitative immunoassay for complexes of prostate-specific antigen with alpha2-macroglobulin. Clin Chem. 1996 Apr; 42(4):545-50. España F, Sánchez-Cuenca J, Estellés A, Gilabert J, Griffin JH, Heeb MJ. PMID: 8605671.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    227. Resistance to activated protein C: a common inherited cause of venous thrombosis. Ann Vasc Surg. 1996 Mar; 10(2):174-7. Gillespie DL, Carrington LR, Griffin JH, Alving BM. PMID: 8733870.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    228. Thrombosis in otherwise well children with the factor V Leiden mutation. J Pediatr. 1996 Mar; 128(3):324-8. Sifontes MT, Nuss R, Jacobson LJ, Griffin JH, Manco-Johnson MJ. PMID: 8774498.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    229. Specific DNA cleavage by manganese(III) complexes. Met Ions Biol Syst. 1996; 33:515-36. Gravert DJ, Griffin JH. PMID: 8742854.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    230. A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations. Thromb Haemost. 1996 Jan; 75(1):62-9. Radtke KP, Greengard JS, Fernández JA, Villoutreix BO, Griffin JH. PMID: 8713781.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    231. Design, synthesis and in vitro evaluation of pyridinium ion based cyclase inhibitors and antifungal agents. Bioorg Med Chem. 1996 Jan; 4(1):97-103. Rose IC, Sharpe BA, Lee RC, Griffin JH, Capobianco JO, Zakula D, Goldman RC. PMID: 8689245.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    232. Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S. Protein Eng. 1995 Dec; 8(12):1253-8. Villoutreix BO, Fernández JA, Teleman O, Griffin JH. PMID: 8869637.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    233. Alternative PCR method for diagnosis of mutation causing activated protein C resistant Gln506-factor V. Thromb Res. 1995 Dec 01; 80(5):441-3. Greengard JS, Xu X, Gandrille S, Griffin JH. PMID: 8588206.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    234. Blood coagulation. The thrombin paradox. Nature. 1995 Nov 23; 378(6555):337-8. Griffin JH. PMID: 7477366.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    235. Prostate specific antigen-alpha 2-macroglobulin complexes in prostate cancer patient sera. Biochem Mol Biol Int. 1995 Nov; 37(5):917-23. Heeb MJ, España F, Gittes RF, Griffin JH. PMID: 8624498.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    236. Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites. J Biol Chem. 1995 Oct 13; 270(41):24216-21. Spek CA, Greengard JS, Griffin JH, Bertina RM, Reitsma PH. PMID: 7592627.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    237. Characterization of a cDNA for rhesus monkey protein C inhibitor--evidence for N-terminal involvement in heparin stimulation. Thromb Haemost. 1995 Oct; 74(4):1079-87. Radtke KP, Fernández JA, Villoutreix BO, Greengard JS, Griffin JH. PMID: 8560417.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    238. A conference of crosstalk: the Gordon Research Conference in Bioorganic Chemistry. Chem Biol. 1995 Aug; 2(8):501-2. Griffin JH. PMID: 9383452.
      View in: PubMed   Mentions:    Fields:    
    239. Activated protein C resistance: molecular mechanisms. Thromb Haemost. 1995 Jul; 74(1):444-8. Griffin JH, Heeb MJ, Kojima Y, Fernández JA, Kojima K, Hackeng TM, Greengard JS. PMID: 8578503.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    240. Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM. Blood. 1995 Jul 01; 86(1):219-24. Gandrille S, Greengard JS, Alhenc-Gelas M, Juhan-Vague I, Abgrall JF, Jude B, Griffin JH, Aiach M. PMID: 7795227.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    241. Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V. Blood. 1995 Jun 15; 85(12):3405-11. Heeb MJ, Kojima Y, Greengard JS, Griffin JH. PMID: 7780127.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    242. Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant. Blood. 1995 Apr 01; 85(7):1704-11. Le DT, Griffin JH, Greengard JS, Mujumdar V, Rapaport SI. PMID: 7703480.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    243. Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C. Biochem J. 1995 Jan 15; 305 ( Pt 2):397-403. Greengard JS, Fernandez JA, Radtke KP, Griffin JH. PMID: 7832752.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    244. Anticoagulant response to activated protein C: method validation and assay comparison. J Clin Lab Anal. 1995; 9(6):418-23. Calkins T, Greengard J, Griffin JH, Bylund D. PMID: 8587012.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    245. Brief report: variability of thrombosis among homozygous siblings with resistance to activated protein C due to an Arg-->Gln mutation in the gene for factor V. N Engl J Med. 1994 Dec 08; 331(23):1559-62. Greengard JS, Eichinger S, Griffin JH, Bauer KA. PMID: 7969326.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    246. Possible structural implications of 20 mutations in the protein C protease domain. Thromb Haemost. 1994 Dec; 72(6):869-73. Greengard JS, Griffin JH, Fisher CL. PMID: 7740456.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    247. A structural model for the prostate disease marker, human prostate-specific antigen. Protein Sci. 1994 Nov; 3(11):2033-44. Villoutreix BO, Getzoff ED, Griffin JH. PMID: 7535613.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    248. Protein C inhibitor is expressed in tubular cells of human kidney. J Clin Invest. 1994 Nov; 94(5):2117-24. Radtke KP, Fernández JA, Greengard JS, Tang WW, Wilson CB, Loskutoff DJ, Scharrer I, Griffin JH. PMID: 7525654.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    249. Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies. Biochemistry. 1994 Sep 20; 33(37):11073-8. Fernández JA, Villoutreix BO, Hackeng TM, Griffin JH, Bouma BN. PMID: 7727359.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    250. Exonic polymorphisms in the protein C gene: interethnic comparison between Caucasians and Asians. Hum Genet. 1994 Aug; 94(2):177-8. Tsay W, Greengard JS, Griffin JH. PMID: 8045564.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    251. Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7370-4. Shi Z, Buntel CJ, Griffin JH. PMID: 8041797.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    252. Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia. Blood. 1994 Jun 01; 83(11):3120-5. Sun X, Evatt B, Griffin JH. PMID: 8193349.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    253. Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet. 1994 May 28; 343(8909):1361-2. Greengard JS, Sun X, Xu X, Fernandez JA, Griffin JH, Evatt B. PMID: 7910348.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    254. Alteration of fibrin network by activated protein C. Blood. 1994 May 01; 83(9):2541-8. Gruber A, Mori E, del Zoppo GJ, Waxman L, Griffin JH. PMID: 8167339.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    255. Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: patterns revealed by three-dimensional molecular modelling of mutations of the protease domain. Proteins. 1994 Apr; 18(4):367-80. Greengard JS, Fisher CL, Villoutreix B, Griffin JH. PMID: 8208728.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    256. Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen. Protein Sci. 1994 Apr; 3(4):588-99. Fisher CL, Greengard JS, Griffin JH. PMID: 8003977.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    257. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2728-32. Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. PMID: 8146182.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    258. A protein S binding site on C4b-binding protein involves beta chain residues 31-45. J Biol Chem. 1994 Jan 28; 269(4):2535-40. Fernández JA, Griffin JH. PMID: 8300581.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    259. Evidence for the regulation of urokinase and tissue type plasminogen activators by the serpin, protein C inhibitor, in semen and blood plasma. Thromb Haemost. 1993 Dec 20; 70(6):989-94. España F, Estellés A, Fernández PJ, Gilabert J, Sánchez-Cuenca J, Griffin JH. PMID: 8165623.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    260. A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va. Biochemistry. 1993 Nov 30; 32(47):12656-63. Mesters RM, Heeb MJ, Griffin JH. PMID: 8251484.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    261. Generation of activated protein C during thrombolysis. Lancet. 1993 Nov 20; 342(8882):1275-6. Gruber A, Pál A, Kiss RG, Sas G, Griffin JH. PMID: 7901587.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    262. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood. 1993 Oct 01; 82(7):1989-93. Griffin JH, Evatt B, Wideman C, Fernández JA. PMID: 8400251.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    263. Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency. Blood Coagul Fibrinolysis. 1993 Oct; 4(5):791-6. Tsay W, Greengard JS, Montgomery RR, McPherson RA, Fucci JC, Koerper MA, Coughlin J, Griffin JH. PMID: 8292730.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    264. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest. 1993 Oct; 92(4):2003-12. Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A. PMID: 8408654.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    265. Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C. Protein Sci. 1993 Sep; 2(9):1482-9. Mesters RM, Heeb MJ, Griffin JH. PMID: 8401232.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    266. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency. Blood. 1993 Aug 15; 82(4):1159-64. Conard J, Bauer KA, Gruber A, Griffin JH, Schwarz HP, Horellou MH, Samama MM, Rosenberg RD. PMID: 8353282.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    267. Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein. J Biol Chem. 1993 Aug 05; 268(22):16788-94. Fernández JA, Heeb MJ, Griffin JH. PMID: 7688369.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    268. Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells. J Neurochem. 1993 Jul; 61(1):344-7. Phillips DJ, Greengard JS, Fernandez JA, Ribeiro M, Evatt BL, Griffin JH, Hooper WC. PMID: 8515282.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    269. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem. 1993 Feb 05; 268(4):2872-7. Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH. PMID: 8428962.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    270. Assembly and expression of an intrinsic factor IX activator complex on the surface of cultured human endothelial cells. J Biol Chem. 1992 Oct 05; 267(28):19833-9. Berrettini M, Schleef RR, Heeb MJ, Hopmeier P, Griffin JH. PMID: 1400299.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    271. The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C. Eur J Biochem. 1992 Aug 15; 208(1):171-8. Bakker HM, Tans G, Janssen-Claessen T, Thomassen MC, Hemker HC, Griffin JH, Rosing J. PMID: 1387359.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    272. Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin. Blood. 1992 Jun 15; 79(12):3203-11. Griffin JH, Gruber A, Fernández JA. PMID: 1534488.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    273. Direct detection of activated protein C in blood from human subjects. Blood. 1992 May 01; 79(9):2340-8. Gruber A, Griffin JH. PMID: 1571547.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    274. High molecular weight kininogen receptor. Methods Enzymol. 1992; 215:369-82. Greengard JS, Griffin JH. PMID: 1331710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    275. Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity. J Biol Chem. 1991 Dec 25; 266(36):24514-9. Mesters RM, Houghten RA, Griffin JH. PMID: 1761551.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    276. Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11241-5. Richman D, Shih CK, Lowy I, Rose J, Prodanovich P, Goff S, Griffin J. PMID: 1722324.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    277. Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates. Circulation. 1991 Dec; 84(6):2454-62. Gruber A, Harker LA, Hanson SR, Kelly AB, Griffin JH. PMID: 1835678.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    278. Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin. J Biol Chem. 1991 Sep 15; 266(26):17606-12. Heeb MJ, Gruber A, Griffin JH. PMID: 1716632.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    279. Evidence of activation of the protein C pathway during acute vascular damage induced by Mediterranean spotted fever. Blood. 1991 Jul 15; 78(2):416-22. Vicente V, España F, Tabernero D, Estellés A, Aznar J, Hendl S, Griffin JH. PMID: 1648982.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    280. Urinary protein C inhibitor. Glycosaminoclycans synthesized by the epithelial kidney cell line TCL-598 enhance its interaction with urokinase. J Biol Chem. 1991 Jun 25; 266(18):11851-7. Geiger M, Priglinger U, Griffin JH, Binder BR. PMID: 1646816.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    281. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood. 1991 Jun 15; 77(12):2641-8. Tans G, Rosing J, Thomassen MC, Heeb MJ, Zwaal RF, Griffin JH. PMID: 2043766.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    282. Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia. Am J Obstet Gynecol. 1991 May; 164(5 Pt 1):1310-6. España F, Gilabert J, Aznar J, Estellés A, Kobayashi T, Griffin JH. PMID: 1852102.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    283. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons. Blood. 1991 Apr 15; 77(8):1754-60. España F, Gruber A, Heeb MJ, Hanson SR, Harker LA, Griffin JH. PMID: 1849759.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    284. Interaction of plasma kallikrein with protein C inhibitor in purified mixtures and in plasma. Thromb Haemost. 1991 Jan 23; 65(1):46-51. España F, Estelles A, Griffin JH, Aznar J. PMID: 1850876.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    285. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8506-10. Kuhn LA, Griffin JH, Fisher CL, Greengard JS, Bouma BN, España F, Tainer JA. PMID: 2172989.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    286. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thromb Res. 1990 Aug 01; 59(3):593-608. España F, Vicente V, Tabernero D, Scharrer I, Griffin JH. PMID: 2173167.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    287. Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis. Circulation. 1990 Aug; 82(2):578-85. Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA. PMID: 2372904.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    288. Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site. Biochemistry. 1990 Jul 17; 29(28):6561-7. Mack DP, Sluka JP, Shin JA, Griffin JH, Simon MI, Dervan PB. PMID: 2204416.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    289. Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358. J Biol Chem. 1990 Feb 05; 265(4):2365-9. Heeb MJ, Bischoff R, Courtney M, Griffin JH. PMID: 2298753.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    290. Aprotinin (trasylol) is a competitive inhibitor of activated protein C. Thromb Res. 1989 Dec 15; 56(6):751-6. España F, Estelles A, Griffin JH, Aznar J, Gilabert J. PMID: 2483763.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    291. Determination of functional and antigenic protein C inhibitor and its complexes with activated protein C in plasma by ELISA's. Thromb Res. 1989 Sep 15; 55(6):671-82. España F, Griffin JH. PMID: 2551066.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    292. Purification and characterization of plasma protein C inhibitor. Thromb Res. 1989 Aug 01; 55(3):369-84. España F, Berrettini M, Griffin JH. PMID: 2551064.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    293. Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo. Blood. 1989 Aug 01; 74(2):722-8. Geiger M, Huber K, Wojta J, Stingl L, Espana F, Griffin JH, Binder BR. PMID: 2752144.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    294. Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system. J Biol Chem. 1989 Jul 15; 264(20):11738-43. Berrettini M, Schleef RR, España F, Loskutoff DJ, Griffin JH. PMID: 2787318.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    295. Familial protein S deficiency with a variant protein S molecule in plasma and platelets. Blood. 1989 Jul; 74(1):213-21. Schwarz HP, Heeb MJ, Lottenberg R, Roberts H, Griffin JH. PMID: 2526663.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    296. A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor. Blood. 1989 Jul; 74(1):173-81. Gladson CL, Schleef RR, Binder BR, Loskutoff DJ, Griffin JH. PMID: 2787675.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    297. Functional assays for protein C activity and protein C inhibitor activity in plasma. Thromb Haemost. 1989 Feb 28; 61(1):86-92. Geiger M, White TM, Griffin JH. PMID: 2546280.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    298. Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model. Blood. 1989 Feb 15; 73(3):639-42. Gruber A, Griffin JH, Harker LA, Hanson SR. PMID: 2917194.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    299. Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation. Blood. 1989 Feb; 73(2):455-61. Heeb MJ, Mosher D, Griffin JH. PMID: 2521800.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    300. Inhibition and complexation of activated protein C by two major inhibitors in plasma. Blood. 1989 Feb; 73(2):446-54. Heeb MJ, España F, Griffin JH. PMID: 2917184.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    301. Immunoblotting studies of the molecular forms of protein C in plasma. Thromb Res. 1988 Oct 01; 52(1):33-43. Heeb MJ, Schwarz HP, White T, Lämmle B, Berrettini M, Griffin JH. PMID: 3201394.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    302. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. J Biol Chem. 1988 Aug 25; 263(24):11613-6. Heeb MJ, Griffin JH. PMID: 3261294.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    303. Detection and quantitation of cleaved and uncleaved high molecular weight kininogen in plasma by ligand blotting with radiolabeled plasma prekallikrein or factor XI. Thromb Haemost. 1988 Apr 08; 59(2):151-61. Lämmle B, Zuraw BL, Heeb MJ, Schwarz HP, Berrettini M, Curd JG, Griffin JH. PMID: 3388291.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    304. Competition of activated protein C and urokinase for a heparin-dependent inhibitor. FASEB J. 1988 Apr; 2(7):2263-7. Geiger M, Heeb MJ, Binder BR, Griffin JH. PMID: 3350241.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    305. Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates. Blood. 1988 Mar; 71(3):562-5. Schwarz HP, Muntean W, Watzke H, Richter B, Griffin JH. PMID: 2964259.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    306. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost. 1988 Feb 25; 59(1):18-22. Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. PMID: 2966450.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    307. Sulfatide bilayers as a surface for contact activation in human plasma. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):1002-7. Tans G, Verkleij AJ, Yu J, Griffin JH. PMID: 3426605.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    308. Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency. Arch Dermatol. 1987 Dec; 123(12):1701a-1706a. Gladson CL, Groncy P, Griffin JH. PMID: 2961308.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    309. Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3. J Biol Chem. 1987 Nov 25; 262(33):15813-6. Heeb MJ, España F, Geiger M, Collen D, Stump DC, Griffin JH. PMID: 2824468.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    310. Studies on the effect of serine protease inhibitors on activated contact factors. Application in amidolytic assays for factor XIIa, plasma kallikrein and factor XIa. Eur J Biochem. 1987 May 04; 164(3):637-42. Tans G, Janssen-Claessen T, Rosing J, Griffin JH. PMID: 3552674.
      View in: PubMed   Mentions: 7     Fields:    
    311. Decreased plasma levels of protein S in well-controlled type I diabetes mellitus. Thromb Haemost. 1987 Apr 07; 57(2):240. Schwarz HP, Schernthaner G, Griffin JH. PMID: 2955541.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    312. Plasma protein S deficiency and thromboembolic disease. Prog Hematol. 1987; 15:39-49. Griffin JH, Heeb MJ, Schwarz HP. PMID: 2971986.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    313. Quantitative immunoblotting of plasma and platelet protein S. Thromb Haemost. 1986 Dec 15; 56(3):382-6. Schwarz HP, Heeb MJ, Lämmle B, Berrettini M, Griffin JH. PMID: 2436335.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    314. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood. 1986 Dec; 68(6):1218-23. Sakata Y, Loskutoff DJ, Gladson CL, Hekman CM, Griffin JH. PMID: 3096399.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    315. Diagnostic efficacy of six plasma proteins in evaluating consumptive coagulopathies. Use of receiver operating characteristic curves to compare antithrombin III, plasminogen, alpha 2-plasmin inhibitor, fibronectin, prothrombin, and protein C. Arch Intern Med. 1986 Oct; 146(10):1997-2002. Cembrowski GS, Griffin JH, Mosher DF. PMID: 3767544.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    316. Detection of in vitro and in vivo cleavage of high molecular weight kininogen in human plasma by immunoblotting with monoclonal antibodies. Blood. 1986 Aug; 68(2):455-62. Berrettini M, Lämmle B, White T, Heeb MJ, Schwarz HP, Zuraw B, Curd J, Griffin JH. PMID: 3730610.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    317. Enhanced specificity of immunoblotting using radiolabeled antigen overlay: studies of blood coagulation factor XII and prekallikrein in plasma. Anal Biochem. 1986 Jul; 156(1):118-25. Lämmle B, Berrettini M, Griffin JH. PMID: 3638135.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    318. Characterization of a variant prekallikrein, prekallikrein Long Beach, from a family with mixed cross-reacting material-positive and cross-reacting material-negative prekallikrein deficiency. J Clin Invest. 1986 Jul; 78(1):170-6. Bouma BN, Kerbiriou DM, Baker J, Griffin JH. PMID: 3487556.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    319. Binding of coagulation factor XI to washed human platelets. Biochemistry. 1986 Jul 01; 25(13):3884-90. Greengard JS, Heeb MJ, Ersdal E, Walsh PN, Griffin JH. PMID: 3017409.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    320. Interaction of S-protein of complement with thrombin and antithrombin III during coagulation. Protection of thrombin by S-protein from antithrombin III inactivation. J Biol Chem. 1986 Jun 05; 261(16):7387-92. Podack ER, Dahlbäck B, Griffin JH. PMID: 3754869.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    321. Effect of L-asparaginase therapy for acute lymphoblastic leukemia on plasma vitamin K-dependent coagulation factors and inhibitors. J Pediatr. 1986 May; 108(5 Pt 1):698-701. Bezeaud A, Drouet L, Leverger G, Griffin JH, Guillin MC. PMID: 2939229.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    322. Quantitative immunoblotting assay of blood coagulation factor XII. Thromb Res. 1986 Mar 15; 41(6):747-59. Lämmle B, Berrettini M, Schwarz HP, Heeb MJ, Griffin JH. PMID: 3085274.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    323. Identification and quantitation of protein S in human platelets. Blood. 1985 Dec; 66(6):1452-5. Schwarz HP, Heeb MJ, Wencel-Drake JD, Griffin JH. PMID: 2933098.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    324. A protein S deficient family with portal vein thrombosis. Thromb Haemost. 1985 Oct 30; 54(3):724. Sas G, Blaskó G, Petrö I, Griffin JH. PMID: 2935967.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    325. Protein-protein interactions in contact activation of blood coagulation. Binding of high molecular weight kininogen and the 5-(iodoacetamido) fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light chains. J Biol Chem. 1985 Oct 15; 260(23):12434-43. Bock PE, Shore JD, Tans G, Griffin JH. PMID: 3850090.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    326. Surface-dependent activation of human factor XII (Hageman factor) by kallikrein and its light chain. Eur J Biochem. 1985 Sep 16; 151(3):531-8. Rosing J, Tans G, Griffin JH. PMID: 3875484.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    327. Plasma concentrations of the natural anticoagulants protein C and protein S in patients with proteinuria. J Lab Clin Med. 1985 Aug; 106(2):218-22. Cosio FG, Harker C, Batard MA, Brandt JT, Griffin JH. PMID: 3160800.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    328. Formation of the fibrin clot: the balance of procoagulant and inhibitory factors. Clin Haematol. 1985 Jun; 14(2):281-342. Lämmle B, Griffin JH. PMID: 2994929.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    329. Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1121-5. Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ. PMID: 3871946.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    330. Receptors for high molecular weight kininogen on stimulated washed human platelets. Biochemistry. 1984 Dec 18; 23(26):6863-9. Greengard JS, Griffin JH. PMID: 6099145.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    331. Plasma protein S deficiency in familial thrombotic disease. Blood. 1984 Dec; 64(6):1297-300. Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. PMID: 6238642.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    332. Studies on human protein C inhibitor in normal and Factor V/VIII deficient plasmas. Thromb Res. 1984 Nov 01; 36(3):197-203. Gardiner JE, Griffin JH. PMID: 6549082.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    333. Studies of protein C in thromboembolic disease. Ric Clin Lab. 1984 Jul-Sep; 14(3):469-73. Griffin JH, Bezeaud A, Evatt B, Mosher D. PMID: 6395293.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    334. Clinical studies of protein C. Semin Thromb Hemost. 1984 Apr; 10(2):162-6. Griffin JH. PMID: 6377499.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    335. Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V. Blood. 1984 Feb; 63(2):486-9. Fulcher CA, Gardiner JE, Griffin JH, Zimmerman TS. PMID: 6419799.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    336. The possible role of platelets in bypassing the contact phase of blood coagulation. Haematologia (Budap). 1984; 17(2):169-78. Walsh PN, Tuszynski GP, Greengard JS, Griffin JH. PMID: 6534825.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    337. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant. Lancet. 1983 Nov 19; 2(8360):1165-8. Branson HE, Katz J, Marble R, Griffin JH. PMID: 6139528.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    338. Immunologic studies of human coagulation factor XI and its complex with high molecular weight kininogen. Blood. 1983 Nov; 62(5):1123-31. Bouma BN, Vlooswijk RA, Griffin JH. PMID: 6626744.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    339. Interaction of human plasma kallikrein and its light chain with C1 inhibitor. Biochemistry. 1983 Sep 27; 22(20):4860-6. van der Graaf F, Koedam JA, Griffin JH, Bouma BN. PMID: 6556071.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    340. Isolation and functional characterization of the active light chain of activated human blood coagulation factor XI. J Biol Chem. 1983 Aug 25; 258(16):9669-75. van der Graaf F, Greengard JS, Bouma BN, Kerbiriou DM, Griffin JH. PMID: 6604052.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    341. Sulfatide-dependent autoactivation of human blood coagulation Factor XII (Hageman Factor). J Biol Chem. 1983 Jul 10; 258(13):8215-22. Tans G, Rosing J, Griffin JH. PMID: 6553053.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    342. A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen. Thromb Res. 1983 Feb 15; 29(4):407-17. Miles LA, Greengard JS, Griffin JH. PMID: 6344314.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    343. Human protein C and thromboembolic disease. Prog Hematol. 1983; 13:265-78. Gardiner JE, Griffin JH. PMID: 6422505.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    344. Immunological studies of human Factor XI and prekallikrein: demonstration of complex formation with high molecular weight kininogen. Adv Exp Med Biol. 1983; 156:109-13. Bouma BN, Vlooswijk RA, Griffin JH. PMID: 6552836.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    345. Initiation of contact activation by sulfatides. Adv Exp Med Biol. 1983; 156:63-72. Tans G, Griffin JH. PMID: 6602464.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    346. Isolation and functional properties of the heavy and light chains of human plasma kallikrein. J Biol Chem. 1982 Dec 10; 257(23):14300-5. van der Graaf F, Tans G, Bouma BN, Griffin JH. PMID: 6815193.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    347. An alternative extrinsic pathway of human blood coagulation. Blood. 1982 Dec; 60(6):1353-8. Marlar RA, Kleiss AJ, Griffin JH. PMID: 7139124.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    348. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation. Blood. 1982 Jul; 60(1):261-4. Griffin JH, Mosher DF, Zimmerman TS, Kleiss AJ. PMID: 6896290.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    349. A bleeding disorder due to deficiency of alpha 2-antiplasmin. Blood. 1982 Jun; 59(6):1246-51. Miles LA, Plow EF, Donnelly KJ, Hougie C, Griffin JH. PMID: 7082827.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    350. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood. 1982 May; 59(5):1067-72. Marlar RA, Kleiss AJ, Griffin JH. PMID: 6803853.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    351. Properties of sulfatides in factor-XII-dependent contact activation. Blood. 1982 Jan; 59(1):69-75. Tans G, Griffin JH. PMID: 6914902.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    352. The biochemistry and pathophysiology of the contact system of plasma. Adv Immunol. 1982; 33:241-306. Cochrane CG, Griffin JH. PMID: 6182767.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    353. Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981 Nov; 68(5):1370-3. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. PMID: 6895379.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
    354. Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents. Blood. 1981 Jun; 57(6):1015-24. Miles LA, Burnier JP, Verlander MS, Goodman M, Kleiss AJ, Griffin JH. PMID: 6452920.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    355. Alternative pathways of thromboplastin-dependent activation of human factor X in plasma. Ann N Y Acad Sci. 1981; 370:325-35. Marlar RA, Griffin JH. PMID: 6943963.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    356. Human protein C: inactivation of factors V and VIII in plasma by the activated molecule. Ann N Y Acad Sci. 1981; 370:303-10. Marlar RA, Kleiss AJ, Griffin JH. PMID: 6791548.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    357. Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI. Blood. 1981 Jan; 57(1):106-18. Walsh PN, Griffin JH. PMID: 7004531.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    358. Platelet-coagulant protein interactions in contact activation. Ann N Y Acad Sci. 1981; 370:241-52. Walsh PN, Griffin JH. PMID: 7023319.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    359. Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease. J Clin Invest. 1980 Nov; 66(5):1186-9. Marlar RA, Griffin JH. PMID: 6253526.
      View in: PubMed   Mentions: 32     Fields:    
    360. Immunological studies of prekallikrein, kallikrein, and high-molecular-weight kininogen in normal and deficient plasmas and in normal plasma after cold-dependent activation. J Lab Clin Med. 1980 Oct; 96(4):693-709. Bouma BN, Kerbiriou DM, Vlooswijk RA, Griffin JH. PMID: 6903191.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    361. Immunochemical studies of human high molecular weight kininogen and of its complexes with plasma prekallikrein or kallikrein. J Biol Chem. 1980 May 10; 255(9):3952-8. Kerbiriou DM, Bouma BN, Griffin JH. PMID: 6154706.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    362. Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate. Biochemistry. 1980 Mar 18; 19(6):1151-60. Bouma BN, Miles LA, Beretta G, Griffin JH. PMID: 6768384.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    363. Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells. J Clin Invest. 1980 Jan; 65(1):197-206. Wiggins RC, Loskutoff DJ, Cochrane CG, Griffin JH, Edgington TS. PMID: 6444222.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    364. Molecular assembly in the contact phase of the Hageman factor system. Am J Med. 1979 Oct; 67(4):657-64. Cochrane CG, Griffin JH. PMID: 386794.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    365. Activation of human factor VII in plasma and in purified systems: roles of activated factor IX, kallikrein, and activated factor XII. J Clin Invest. 1979 Oct; 64(4):1056-65. Seligsohn U, Osterud B, Brown SF, Griffin JH, Rapaport SI. PMID: 479368.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    366. Rabbit blood coagulation factor XI. Purification and properties. Thromb Res. 1979; 15(3-4):475-86. Wiggins RC, Cochrane CG, Griffin JH. PMID: 494156.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    367. Molecular mechanisms of surface-dependent activation of Hageman factor (Factor XII). Adv Exp Med Biol. 1979; 120B:39-51. Griffin JH, Beretta G. PMID: 517240.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    368. Recent advances in the understanding of contact activation reactions. Semin Thromb Hemost. 1979; 5(4):254-73. Griffin JH, Cochrane CG. PMID: 386517.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    369. Rabbit blood coagulation factor XI. Mechanism of activation of rabbit Hageman factor (factor XII). Thromb Res. 1979; 15(3-4):487-95. Wiggins RC, Cochrane CG, Griffin JH. PMID: 494157.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    370. Evidence for the participation of both activated factor XII and activated factor IX in cold-promoted activation of factor VII. Thromb Res. 1978 Dec; 13(6):1049-56. Seligsohn U, Osterud B, Griffin JH, Rapaport SI. PMID: 749262.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    371. Human blood coagulation factor IX. Purification, properties, and mechanism of activation by activated factor XI. J Biol Chem. 1978 Sep 10; 253(17):5946-51. Osterud B, Bouma BN, Griffin JH. PMID: 681330.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    372. Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). Proc Natl Acad Sci U S A. 1978 Apr; 75(4):1998-2002. Griffin JH. PMID: 273926.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    373. Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma. J Exp Med. 1978 Mar 01; 147(3):719-29. Revak SD, Cochrane CG, Bouma BN, Griffin JH. PMID: 632748.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    374. Deficiency of factor XII-dependent plasminogen proactivator in prekallikrein-deficient plasma. J Lab Clin Med. 1978 Jan; 91(1):148-55. Bouma BN, Griffin JH. PMID: 73563.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    375. Circulating inhibitors of blood coagulation associated with procainamide-induced lupus erythematosus. Am J Hematol. 1978; 4(4):401-7. Davis S, Furie BC, Griffin JH, Furie B, Willey R. PMID: 717399.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    376. Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for the analysis of peptide hormone interactions with bovine neurophysin I using 13C nuclear magnetic resonance spectroscopy. Biochemistry. 1977 Nov 15; 16(23):5061-5. Convert O, Griffin JH, Di Bello C, Nicolas P, Cohen P. PMID: 562184.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    377. Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4636-40. Wiggins RC, Bouma BN, Cochrane CG, Griffin JH. PMID: 270705.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    378. Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII. J Biol Chem. 1977 Sep 25; 252(18):6432-7. Bouma BN, Griffin JH. PMID: 893417.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    379. Carbon-13 nuclear magnetic resonance studies of the binding of selectively 13C-enriched oxytocins to the neurophypophyseal protein, bovine neurophysin II. Biochemistry. 1977 Sep 20; 16(19):4194-8. Griffin JH, DiBello C, Alazard R, Nicolas P, Cohen P. PMID: 561612.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    380. The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen. J Clin Invest. 1977 Jun; 59(6):1167-75. Revak SD, Cochrane CG, Griffin JH. PMID: 864009.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    381. Circular dichroism and absorbance properties of nitrotyrosyl chromophores in staphylococcal nuclease and in a model diketopiperazine. J Biol Chem. 1975 Feb 25; 250(4):1445-50. Di Bello C, Griffin JH. PMID: 234457.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    382. Studies of bovine neurophysin-neurohypophyseal hormone interactions. Ann N Y Acad Sci. 1975 Feb 21; 248:463-79. Cohen P, Camier M, Wolff J, Alazard R, Cohen JS, Griffin JH. PMID: 235235.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    383. Application of nuclear magnetic resonance spectroscopy to proteins. Biochimie. 1975; 57(4):453-60. Griffin JH, Furie B, Schechter AN. PMID: 1148335.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    384. Interactions of bovine neurophysin II with oxytocin and (8-lysine) vasopressin. High resolution proton nuclear magnetic resonance spectroscopy studies. J Biol Chem. 1974 Nov 10; 249(21):6895-900. Alazard R, Cohen P, Cohen JS, Griffin JH. PMID: 4423570.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    385. Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme. Ann N Y Acad Sci. 1973 Dec 31; 222:693-708. Griffin JH, Schechter AN, Cohen JS. PMID: 4522440.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    386. Complex formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region. Absorbance and circular dichroism difference spectroscopic studies. J Biol Chem. 1973 Dec 10; 248(23):7975-8. Griffin JH, Alazard R, Cohen P. PMID: 4796247.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    387. The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119. Biochemistry. 1973 May 22; 12(11):2096-9. Griffin JH, Cohen JS, Schechter AN. PMID: 4735881.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    388. Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy. J Biol Chem. 1972 Oct 25; 247(20):6482-90. Griffin JH, Rosenbusch JP, Weber KK, Blout ER. PMID: 4561937.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    389. Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits. Biochemistry. 1970 Mar 03; 9(5):1195-205. Griffin JH, Criddle RS. PMID: 4313938.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
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