John Cashman
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School | Vc-academic Affairs |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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Research Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Role of Curcuminoids and Tricalcium Phosphate Ceramic in Rat Spinal Fusion. Tissue Eng Part C Methods. 2020 11; 26(11):577-589.
Ryan DA, Cheng J, Masuda K, Cashman JR. PMID: 33086948.
View in: PubMed Mentions: Fields:
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Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity. Cell Stem Cell. 2020 Nov 05; 27(5):813-821.e6.
McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL, Kass RS, Cashman JR, Mercola M. PMID: 32931730.
View in: PubMed Mentions: Fields:
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Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression. Invest New Drugs. 2020 Sep 11.
Cheng J, Cashman JR. PMID: 32915418.
View in: PubMed Mentions: Fields:
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PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin ß3-KRAS-dependent pancreatic cancer stem cells. Sci Rep. 2020 06 08; 10(1):9162.
Cheng J, Cashman JR. PMID: 32514015.
View in: PubMed Mentions: 1 Fields:
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N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide. Drug Metab Dispos. 2020 02; 48(2):106-115.
Cashman JR, Gohdes M, de Kater A, Schoenhard G. PMID: 31727673.
View in: PubMed Mentions: Fields:
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A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer. J Pharmacol Exp Ther. 2019 12; 371(3):703-712.
Cheng J, Moore S, Gomez-Galeno J, Lee DH, Okolotowicz KJ, Cashman JR. PMID: 31582422.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 07 25; 9(1):10811.
Hurtado C, Safarova A, Smith M, Chung R, Bruyneel AAN, Gomez-Galeno J, Oswald F, Larson CJ, Cashman JR, Ruiz-Lozano P, Janiak P, Suzuki T, Mercola M. PMID: 31346210.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. Am J Cancer Res. 2019; 9(2):390-405.
Cheng J, Okolotowicz KJ, Ryan D, Mose E, Lowy AM, Cashman JR. PMID: 30906636.
View in: PubMed Mentions:
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Curcumin and Novel Synthetic Analogs in Cell-Based Studies of Alzheimer's Disease. Front Pharmacol. 2018; 9:1404.
Gagliardi S, Franco V, Sorrentino S, Zucca S, Pandini C, Rota P, Bernuzzi S, Costa A, Sinforiani E, Pansarasa O, Cashman JR, Cereda C. PMID: 30559668.
View in: PubMed Mentions:
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b-Annulated 1,4-dihydropyridines as Notch inhibitors. Bioorg Med Chem Lett. 2018 11 01; 28(20):3363-3367.
Gómez-Galeno JE, Hurtado C, Cheng J, Yardimci C, Mercola M, Cashman JR. PMID: 30201292.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Novel tertiary sulfonamides as potent anti-cancer agents. Bioorg Med Chem. 2018 08 15; 26(15):4441-4451.
Okolotowicz KJ, Dwyer M, Ryan D, Cheng J, Cashman EA, Moore S, Mercola M, Cashman JR. PMID: 30075999.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer. Cancer Res. 2018 09 01; 78(17):5072-5083.
Cheng J, Dwyer M, Okolotowicz KJ, Mercola M, Cashman JR. PMID: 30032112.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017; 8:766.
McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M. PMID: 29075196.
View in: PubMed Mentions:
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1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells. Bioorg Med Chem. 2015 Sep 01; 23(17):5282-92.
Okolotowicz KJ, Bushway P, Lanier M, Gilley C, Mercola M, Cashman JR. PMID: 26278027.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Novel human butyrylcholinesterase variants: toward organophosphonate detoxication. Biochemistry. 2014 Jul 15; 53(27):4476-87.
Dwyer M, Javor S, Ryan DA, Smith EM, Wang B, Zhang J, Cashman JR. PMID: 24902043.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ-opioid receptor antagonist. J Pharmacol Exp Ther. 2014 Jul; 350(1):171-80.
Cashman JR, Azar MR. PMID: 24817033.
View in: PubMed Mentions: 7 Fields: Translation: Animals
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Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFß signaling. J Med Chem. 2012 Nov 26; 55(22):9946-57.
Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. PMID: 23130626.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Regulation of FMO and PON detoxication systems in ALS human tissues. Neurotox Res. 2013 May; 23(4):370-7.
Gagliardi S, Abel K, Bianchi M, Milani P, Bernuzzi S, Corato M, Ceroni M, Cashman JR, Cereda C. PMID: 23073612.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52.
Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. PMID: 22862949.
View in: PubMed Mentions: 43 Fields: Translation: HumansAnimalsCells
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HNF4a antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27; 19(7):806-18.
Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. PMID: 22840769.
View in: PubMed Mentions: 20 Fields: Translation: HumansCells
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Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response. J Med Chem. 2012 Jan 26; 55(2):697-708.
Lanier M, Schade D, Willems E, Tsuda M, Spiering S, Kalisiak J, Mercola M, Cashman JR. PMID: 22191557.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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Nonquaternary reactivators for organophosphate-inhibited cholinesterases. J Med Chem. 2012 Jan 12; 55(1):465-74.
Kalisiak J, Ralph EC, Cashman JR. PMID: 22206546.
View in: PubMed Mentions: 10 Fields: Translation: Animals
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Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ Res. 2011 Aug 05; 109(4):360-4.
Willems E, Spiering S, Davidovics H, Lanier M, Xia Z, Dawson M, Cashman J, Mercola M. PMID: 21737789.
View in: PubMed Mentions: 80 Fields: Translation: HumansCells
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Amidine-oximes: reactivators for organophosphate exposure. J Med Chem. 2011 May 12; 54(9):3319-30.
Kalisiak J, Ralph EC, Zhang J, Cashman JR. PMID: 21438612.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimals
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A chemical biology approach to myocardial regeneration. J Cardiovasc Transl Res. 2011 Jun; 4(3):340-50.
Willems E, Lanier M, Forte E, Lo F, Cashman J, Mercola M. PMID: 21424858.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Flavin-containing monooxygenase mRNA levels are up-regulated in als brain areas in SOD1-mutant mice. Neurotox Res. 2011 Aug; 20(2):150-8.
Gagliardi S, Ogliari P, Davin A, Corato M, Cova E, Abel K, Cashman JR, Ceroni M, Cereda C. PMID: 21082301.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules. J Med Chem. 2010 Jun 24; 53(12):4793-7.
Peddibhotla S, Shi R, Khan P, Smith LH, Mangravita-Novo A, Vicchiarelli M, Su Y, Okolotowicz KJ, Cashman JR, Reed JC, Roth GP. PMID: 20481485.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis. Neurobiol Dis. 2010 Aug; 39(2):198-203.
Gagliardi S, Cova E, Davin A, Guareschi S, Abel K, Alvisi E, Laforenza U, Ghidoni R, Cashman JR, Ceroni M, Cereda C. PMID: 20399857.
View in: PubMed Mentions: 25 Fields: Translation: HumansCells
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Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C. ACS Chem Biol. 2010 Mar 19; 5(3):287-99.
Shi R, Re D, Dudl E, Cuddy M, Okolotowicz KJ, Dahl R, Su Y, Hurder A, Kitada S, Peddibhotla S, Roth GP, Smith LH, Kipps TJ, Cosford N, Cashman J, Reed JC. PMID: 20141195.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2009 Oct; 22(10):1669-79.
Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J. PMID: 19715346.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. Chem Res Toxicol. 2009 Oct; 22(10):1680-8.
Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O. PMID: 19715348.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl). 2009 Sep; 205(4):565-75.
Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF. PMID: 19484223.
View in: PubMed Mentions: 58 Fields: Translation: AnimalsCells
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Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J Med Chem. 2009 Mar 26; 52(6):1530-9.
Cashman JR, Voelker T, Zhang HT, O'Donnell JM. PMID: 19256502.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2009; 17(3):703-17.
Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M. PMID: 19433889.
View in: PubMed Mentions: 60 Fields: Translation: HumansCellsCTClinical Trials
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Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models. Drug Metab Dispos. 2009 Mar; 37(3):462-8.
Zhang J, Chaluvadi MR, Reddy R, Motika MS, Richardson TA, Cashman JR, Morgan ET. PMID: 19088265.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Immune defects in Alzheimer's disease: new medications development. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S13.
Cashman JR, Ghirmai S, Abel KJ, Fiala M. PMID: 19090986.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14beta-dihydroxy-4, 5alpha-epoxymorphinan: potential alcohol-cessation agents. J Med Chem. 2008 Mar 27; 51(6):1913-24.
Ghirmai S, Azar MR, Polgar WE, Berzetei-Gurske I, Cashman JR. PMID: 18298057.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem. 2007 Dec 27; 50(26):6607-17.
Stebbins JL, Zhang Z, Chen J, Wu B, Emdadi A, Williams ME, Cashman J, Pellecchia M. PMID: 18038971.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30; 49(24):6987-7001.
Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. PMID: 17125252.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15; 15(6):1583-6.
MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. PMID: 15745801.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13; 48(1):224-39.
Denton TT, Zhang X, Cashman JR. PMID: 15634016.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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Dynamic medicinal chemistry in the elaboration of morphine-6-glucuronide analogs. Curr Top Med Chem. 2005; 5(6):585-94.
Cashman JR, MacDougall JM. PMID: 16022681.
View in: PubMed Mentions: 2 Fields:
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Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide. J Med Chem. 2004 Nov 04; 47(23):5809-15.
MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. PMID: 15509180.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Alternative processing events in human FMO genes. Mol Pharmacol. 2004 Jun; 65(6):1517-25.
Lattard V, Zhang J, Cashman JR. PMID: 15155844.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Inhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analogues. Chem Res Toxicol. 2003 Aug; 16(8):988-93.
MacDougall JM, Fandrick K, Zhang X, Serafin SV, Cashman JR. PMID: 12924926.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab Dispos. 2002 Oct; 30(10):1043-52.
Cashman JR, Zhang J. PMID: 12228178.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimals
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Year | Publications |
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2002 | 1 | 2003 | 1 | 2004 | 2 | 2005 | 3 | 2006 | 1 | 2007 | 1 | 2008 | 3 | 2009 | 5 | 2010 | 4 | 2011 | 4 | 2012 | 5 | 2014 | 2 | 2015 | 1 | 2017 | 1 | 2018 | 4 | 2019 | 4 | 2020 | 4 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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