John Cashman

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Address9500 Gilman Drive #
La Jolla CA 92093
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    Non-Toxic Small Molecule for Inhibition of Prostate Cancer
    NIH R43CA203566Sep 23, 2015 - Sep 22, 2017
    Role: Co-Principal Investigator
    Novel Small Molecule Therapeutics for Pancreatic Cancer
    NIH R41CA176931Jun 1, 2014 - May 31, 2016
    Role: Co-Principal Investigator
    Small Molecule Toolbox: Cardiomyocytes from Human Stem Cells
    NIH R41HL108714Jul 1, 2011 - Jun 30, 2012
    Role: Co-Principal Investigator
    Novel Medicinal Chemicals: Cardiomyogenesis from Human Stem Cells
    NIH R41HL107088Mar 4, 2011 - Dec 31, 2012
    Role: Co-Principal Investigator
    Biosensor for real-time chemical monitoring
    NIH U01NS058038Sep 30, 2006 - May 31, 2012
    Role: Principal Investigator
    New Opioids for Alcoholism
    NIH R41AA016029May 1, 2006 - Apr 30, 2009
    Role: Principal Investigator
    Amine N-Oxygenation by FMO3 and FMO4
    NIH R01DK059618Apr 15, 2002 - Feb 28, 2009
    Role: Principal Investigator
    NIH R01DA011547Sep 30, 1997 - Jul 31, 2003
    Role: Principal Investigator
    NIH K02DA000269May 1, 1997 - Apr 30, 2002
    Role: Principal Investigator
    NIH R01DA008531Sep 30, 1993 - Jul 31, 1998
    Role: Principal Investigator
    NIH R01GM036426Sep 19, 1988 - Dec 31, 2000
    Role: Principal Investigator
    NIH R01DK036398Mar 1, 1988 - Feb 29, 1992
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human iPSC-derived Cardiomyocytes and Pyridyl-Phenyl Mexiletine Analogs. Bioorg Med Chem Lett. 2021 May 29; 128162. Johnson M, Gomez-Galeno J, Ryan D, Okolotowicz K, McKeithan WL, Sampson KJ, Kass RS, Mercola M, Cashman JR. PMID: 34062251.
      View in: PubMed   Mentions:
    2. Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes. J Med Chem. 2021 May 13; 64(9):5384-5403. Cashman JR, Ryan D, McKeithan WL, Okolotowicz K, Gomez-Galeno J, Johnson M, Sampson KJ, Kass RS, Pezhouman A, Karagueuzian HS, Mercola M. PMID: 33942619.
      View in: PubMed   Mentions:    Fields:    
    3. Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell Chem Biol. 2021 Jan 20. Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, Wu JC, Moon RT, Si Dong PD, Karakikes I, Cashman JR, Mercola M. PMID: 33503403.
      View in: PubMed   Mentions:    Fields:    
    4. Role of Curcuminoids and Tricalcium Phosphate Ceramic in Rat Spinal Fusion. Tissue Eng Part C Methods. 2020 11; 26(11):577-589. Ryan DA, Cheng J, Masuda K, Cashman JR. PMID: 33086948.
      View in: PubMed   Mentions:    Fields:    
    5. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity. Cell Stem Cell. 2020 Nov 05; 27(5):813-821.e6. McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL, Kass RS, Cashman JR, Mercola M. PMID: 32931730.
      View in: PubMed   Mentions:    Fields:    
    6. Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression. Invest New Drugs. 2021 Feb; 39(1):131-141. Cheng J, Cashman JR. PMID: 32915418.
      View in: PubMed   Mentions:    Fields:    
    7. PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin ß3-KRAS-dependent pancreatic cancer stem cells. Sci Rep. 2020 06 08; 10(1):9162. Cheng J, Cashman JR. PMID: 32514015.
      View in: PubMed   Mentions: 1     Fields:    
    8. N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide. Drug Metab Dispos. 2020 02; 48(2):106-115. Cashman JR, Gohdes M, de Kater A, Schoenhard G. PMID: 31727673.
      View in: PubMed   Mentions:    Fields:    
    9. A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer. J Pharmacol Exp Ther. 2019 12; 371(3):703-712. Cheng J, Moore S, Gomez-Galeno J, Lee DH, Okolotowicz KJ, Cashman JR. PMID: 31582422.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 07 25; 9(1):10811. Hurtado C, Safarova A, Smith M, Chung R, Bruyneel AAN, Gomez-Galeno J, Oswald F, Larson CJ, Cashman JR, Ruiz-Lozano P, Janiak P, Suzuki T, Mercola M. PMID: 31346210.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. Am J Cancer Res. 2019; 9(2):390-405. Cheng J, Okolotowicz KJ, Ryan D, Mose E, Lowy AM, Cashman JR. PMID: 30906636.
      View in: PubMed   Mentions:
    12. Curcumin and Novel Synthetic Analogs in Cell-Based Studies of Alzheimer's Disease. Front Pharmacol. 2018; 9:1404. Gagliardi S, Franco V, Sorrentino S, Zucca S, Pandini C, Rota P, Bernuzzi S, Costa A, Sinforiani E, Pansarasa O, Cashman JR, Cereda C. PMID: 30559668.
      View in: PubMed   Mentions:
    13. b-Annulated 1,4-dihydropyridines as Notch inhibitors. Bioorg Med Chem Lett. 2018 11 01; 28(20):3363-3367. Gómez-Galeno JE, Hurtado C, Cheng J, Yardimci C, Mercola M, Cashman JR. PMID: 30201292.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Novel tertiary sulfonamides as potent anti-cancer agents. Bioorg Med Chem. 2018 08 15; 26(15):4441-4451. Okolotowicz KJ, Dwyer M, Ryan D, Cheng J, Cashman EA, Moore S, Mercola M, Cashman JR. PMID: 30075999.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer. Cancer Res. 2018 09 01; 78(17):5072-5083. Cheng J, Dwyer M, Okolotowicz KJ, Mercola M, Cashman JR. PMID: 30032112.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017; 8:766. McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M. PMID: 29075196.
      View in: PubMed   Mentions:
    17. 1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells. Bioorg Med Chem. 2015 Sep 01; 23(17):5282-92. Okolotowicz KJ, Bushway P, Lanier M, Gilley C, Mercola M, Cashman JR. PMID: 26278027.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    18. Potent inhibition of alcohol self-administration in alcohol-preferring rats by a ?-opioid receptor antagonist. J Pharmacol Exp Ther. 2014 Jul; 350(1):171-80. Cashman JR, Azar MR. PMID: 24817033.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    19. Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFß signaling. J Med Chem. 2012 Nov 26; 55(22):9946-57. Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. PMID: 23130626.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Regulation of FMO and PON detoxication systems in ALS human tissues. Neurotox Res. 2013 May; 23(4):370-7. Gagliardi S, Abel K, Bianchi M, Milani P, Bernuzzi S, Corato M, Ceroni M, Cashman JR, Cereda C. PMID: 23073612.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. PMID: 22862949.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    22. HNF4a antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27; 19(7):806-18. Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. PMID: 22840769.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    23. Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response. J Med Chem. 2012 Jan 26; 55(2):697-708. Lanier M, Schade D, Willems E, Tsuda M, Spiering S, Kalisiak J, Mercola M, Cashman JR. PMID: 22191557.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    24. Nonquaternary reactivators for organophosphate-inhibited cholinesterases. J Med Chem. 2012 Jan 12; 55(1):465-74. Kalisiak J, Ralph EC, Cashman JR. PMID: 22206546.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    25. Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ Res. 2011 Aug 05; 109(4):360-4. Willems E, Spiering S, Davidovics H, Lanier M, Xia Z, Dawson M, Cashman J, Mercola M. PMID: 21737789.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    26. Amidine-oximes: reactivators for organophosphate exposure. J Med Chem. 2011 May 12; 54(9):3319-30. Kalisiak J, Ralph EC, Zhang J, Cashman JR. PMID: 21438612.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    27. A chemical biology approach to myocardial regeneration. J Cardiovasc Transl Res. 2011 Jun; 4(3):340-50. Willems E, Lanier M, Forte E, Lo F, Cashman J, Mercola M. PMID: 21424858.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Flavin-containing monooxygenase mRNA levels are up-regulated in als brain areas in SOD1-mutant mice. Neurotox Res. 2011 Aug; 20(2):150-8. Gagliardi S, Ogliari P, Davin A, Corato M, Cova E, Abel K, Cashman JR, Ceroni M, Cereda C. PMID: 21082301.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules. J Med Chem. 2010 Jun 24; 53(12):4793-7. Peddibhotla S, Shi R, Khan P, Smith LH, Mangravita-Novo A, Vicchiarelli M, Su Y, Okolotowicz KJ, Cashman JR, Reed JC, Roth GP. PMID: 20481485.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis. Neurobiol Dis. 2010 Aug; 39(2):198-203. Gagliardi S, Cova E, Davin A, Guareschi S, Abel K, Alvisi E, Laforenza U, Ghidoni R, Cashman JR, Ceroni M, Cereda C. PMID: 20399857.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    31. Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C. ACS Chem Biol. 2010 Mar 19; 5(3):287-99. Shi R, Re D, Dudl E, Cuddy M, Okolotowicz KJ, Dahl R, Su Y, Hurder A, Kitada S, Peddibhotla S, Roth GP, Smith LH, Kipps TJ, Cosford N, Cashman J, Reed JC. PMID: 20141195.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    32. Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2009 Oct; 22(10):1669-79. Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J. PMID: 19715346.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. Chem Res Toxicol. 2009 Oct; 22(10):1680-8. Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O. PMID: 19715348.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    34. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl). 2009 Sep; 205(4):565-75. Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF. PMID: 19484223.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    35. Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J Med Chem. 2009 Mar 26; 52(6):1530-9. Cashman JR, Voelker T, Zhang HT, O'Donnell JM. PMID: 19256502.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    36. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2009; 17(3):703-17. Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M. PMID: 19433889.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCellsCTClinical Trials
    37. Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models. Drug Metab Dispos. 2009 Mar; 37(3):462-8. Zhang J, Chaluvadi MR, Reddy R, Motika MS, Richardson TA, Cashman JR, Morgan ET. PMID: 19088265.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Immune defects in Alzheimer's disease: new medications development. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S13. Cashman JR, Ghirmai S, Abel KJ, Fiala M. PMID: 19090986.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14beta-dihydroxy-4, 5alpha-epoxymorphinan: potential alcohol-cessation agents. J Med Chem. 2008 Mar 27; 51(6):1913-24. Ghirmai S, Azar MR, Polgar WE, Berzetei-Gurske I, Cashman JR. PMID: 18298057.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem. 2007 Dec 27; 50(26):6607-17. Stebbins JL, Zhang Z, Chen J, Wu B, Emdadi A, Williams ME, Cashman J, Pellecchia M. PMID: 18038971.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30; 49(24):6987-7001. Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. PMID: 17125252.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    42. Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15; 15(6):1583-6. MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. PMID: 15745801.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    43. 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13; 48(1):224-39. Denton TT, Zhang X, Cashman JR. PMID: 15634016.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    44. Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide. J Med Chem. 2004 Nov 04; 47(23):5809-15. MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. PMID: 15509180.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    45. Alternative processing events in human FMO genes. Mol Pharmacol. 2004 Jun; 65(6):1517-25. Lattard V, Zhang J, Cashman JR. PMID: 15155844.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    46. Inhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analogues. Chem Res Toxicol. 2003 Aug; 16(8):988-93. MacDougall JM, Fandrick K, Zhang X, Serafin SV, Cashman JR. PMID: 12924926.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
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