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John Carethers

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0063
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    (PQ3) Immune Modulation of DNA Mismatch Repair in Colorectal Cancer
    NIH/NCI R01CA206010Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Inflammatory Differentiation of Colorectal Cancer Among African Americans
    NIH/NCI U01CA162147Sep 1, 2012 - Aug 31, 2017
    Role: Principal Investigator
    The UCSD Digestive Diseases Research Development Center
    NIH/NIDDK R24DK080506Apr 10, 2008 - Jun 30, 2010
    Role: Co-Principal Investigator
    Microsatellite Instability and the DNA Mismatch Repair System
    NIH/NIDDK R01DK067287Apr 1, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Pathogensis of Hamartomatous Polyps
    NIH/NCI R01CA090231Sep 1, 2000 - Aug 31, 2006
    Role: Principal Investigator
    CELL CYCLE REGULATION BY THE MISMATCH REPAIR GENES
    NIH/NIDDK K08DK002433Sep 30, 1995 - Aug 31, 2000
    Role: Principal Investigator
    Training Grant in Gastroenterology
    NIH/NIDDK T32DK007202Jul 1, 1976 - Mar 31, 1992
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Human DNA Mismatch Repair Protein MSH3 Contains Nuclear Localization and Export Signals That Enable Nuclear-Cytosolic Shuttling in Response to Inflammation. Mol Cell Biol. 2020 Jun 15; 40(13). Tseng-Rogenski SS, Munakata K, Choi DY, Martin PK, Mehta S, Koi M, Zheng W, Zhang Y, Carethers JM. PMID: 32284349.
      View in: PubMed   Mentions:    Fields:    
    2. Altered ARID1A expression in colorectal cancer. BMC Cancer. 2020 Apr 25; 20(1):350. Erfani M, Hosseini SV, Mokhtari M, Zamani M, Tahmasebi K, Alizadeh Naini M, Taghavi A, Carethers JM, Koi M, Brim H, Mokarram P, Ashktorab H. PMID: 32334542.
      View in: PubMed   Mentions:    Fields:    
    3. Rising Incidence of Colorectal Cancer in Young Adults Corresponds With Increasing Surgical Resections in Obese Patients. Clin Transl Gastroenterol. 2020 Apr; 11(4):e00160. Hussan H, Patel A, Le Roux M, Cruz-Monserrate Z, Porter K, Clinton SK, Carethers JM, Courneya KS. PMID: 32352680.
      View in: PubMed   Mentions:    Fields:    
    4. Tetranucleotide Microsatellite Mutational Behavior Assessed in Real Time: Implications for Future Microsatellite Panels. Cell Mol Gastroenterol Hepatol. 2020; 9(4):689-704. Raeker MÖ, Pierre-Charles J, Carethers JM. PMID: 31982570.
      View in: PubMed   Mentions: 1     Fields:    
    5. Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps. Dig Dis Sci. 2019 Dec 12. Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H. PMID: 31832971.
      View in: PubMed   Mentions:    Fields:    
    6. Diversification in the medical sciences fuels growth of physician-scientists. J Clin Invest. 2019 12 02; 129(12):5051-5054. Carethers JM. PMID: 31746810.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement. Clin Transl Gastroenterol. 2019 12; 10(12):e00105. Munakata K, Koi M, Kitajima T, Tseng-Rogenski S, Uemura M, Matsuno H, Kawai K, Sekido Y, Mizushima T, Toiyama Y, Yamada T, Mano M, Mita E, Kusunoki M, Mori M, Carethers JM. PMID: 31789935.
      View in: PubMed   Mentions: 2     Fields:    
    8. High predictability for identifying Lynch syndrome via microsatellite instability testing or immunohistochemistry in all Lynch-associated tumor types. Transl Cancer Res. 2019 Dec; 8(Suppl 6):S559-S563. Carethers JM. PMID: 32266124.
      View in: PubMed   Mentions:
    9. Current Approaches to Germline Cancer Genetic Testing. Annu Rev Med. 2020 01 27; 71:85-102. Stoffel EM, Carethers JM. PMID: 31756137.
      View in: PubMed   Mentions:    Fields:    
    10. Causes of Socioeconomic Disparities in Colorectal Cancer and Intervention Framework and Strategies. Gastroenterology. 2020 01; 158(2):354-367. Carethers JM, Doubeni CA. PMID: 31682851.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    11. Fecal DNA Testing for Colorectal Cancer Screening. Annu Rev Med. 2020 01 27; 71:59-69. Carethers JM. PMID: 31451044.
      View in: PubMed   Mentions:    Fields:    
    12. Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort. Gastroenterology. 2019 08; 157(2):572-574. Ashktorab H, Delker D, Kanth P, Goel A, Carethers JM, Brim H. PMID: 31004568.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism. Oncogene. 2019 05; 38(20):3946-3961. Tang B, Wu J, Zhu MX, Sun X, Liu J, Xie R, Dong TX, Xiao Y, Carethers JM, Yang S, Dong H. PMID: 30692637.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Clinical and Genetic Factors to Inform Reducing Colorectal Cancer Disparitites in African Americans. Front Oncol. 2018; 8:531. Carethers JM. PMID: 30524961.
      View in: PubMed   Mentions:
    15. Diversity Within US Gastroenterology Physician Practices: The Pipeline, Cultural Competencies, and Gastroenterology Societies Approaches. Gastroenterology. 2019 03; 156(4):829-833. Carethers JM, Quezada SM, Carr RM, Day LW. PMID: 30452917.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Risk factors for colon location of cancer. Transl Gastroenterol Hepatol. 2018; 3:76. Carethers JM. PMID: 30505963.
      View in: PubMed   Mentions:
    17. Fusobacterium nucleatum Infection in Colorectal Cancer: Linking Inflammation, DNA Mismatch Repair and Genetic and Epigenetic Alterations. J Anus Rectum Colon. 2018; 2(2):37-46. Koi M, Okita Y, Carethers JM. PMID: 30116794.
      View in: PubMed   Mentions:
    18. Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer. World J Gastrointest Oncol. 2018 Jan 15; 10(1):1-14. Koi M, Tseng-Rogenski SS, Carethers JM. PMID: 29375743.
      View in: PubMed   Mentions:
    19. MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells. Oncotarget. 2018 Feb 20; 9(14):11477-11488. Suzuki S, Iwaizumi M, Yamada H, Sugiyama T, Hamaya Y, Furuta T, Kanaoka S, Sugimura H, Miyajima H, Osawa S, Carethers JM, Sugimoto K. PMID: 29545913.
      View in: PubMed   Mentions: 2     Fields:    
    20. Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel. Cancer Res. 2017 12 01; 77(23):6499-6512. Xie R, Xu J, Xiao Y, Wu J, Wan H, Tang B, Liu J, Fan Y, Wang S, Wu Y, Dong TX, Zhu MX, Carethers JM, Dong H, Yang S. PMID: 28951460.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. The colorectal cancer immune microenvironment and approach to immunotherapies. Future Oncol. 2017 Aug; 13(18):1633-1647. Koi M, Carethers JM. PMID: 28829193.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    22. Racial Disparity in Gastrointestinal Cancer Risk. Gastroenterology. 2017 10; 153(4):910-923. Ashktorab H, Kupfer SS, Brim H, Carethers JM. PMID: 28807841.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    23. Charting the Future of Cancer Health Disparities Research: A Position Statement From the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute. J Clin Oncol. 2017 09 10; 35(26):3075-3082. Polite BN, Adams-Campbell LL, Brawley OW, Bickell N, Carethers JM, Flowers CR, Foti M, Gomez SL, Griggs JJ, Lathan CS, Li CI, Lichtenfeld JL, McCaskill-Stevens W, Paskett ED. PMID: 28737975.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Charting the future of cancer health disparities research: A position statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute. CA Cancer J Clin. 2017 09; 67(5):353-361. Polite BN, Adams-Campbell LL, Brawley OW, Bickell N, Carethers JM, Flowers CR, Foti M, Gomez SL, Griggs JJ, Lathan CS, Li CI, Lichtenfeld JL, McCaskill-Stevens W, Paskett ED. PMID: 28738442.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Charting the Future of Cancer Health Disparities Research: A Position Statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute. Cancer Res. 2017 09 01; 77(17):4548-4555. Polite BN, Adams-Campbell LL, Brawley OW, Bickell N, Carethers JM, Flowers CR, Foti M, Gomez SL, Griggs JJ, Lathan CS, Li CI, Lichtenfeld JL, McCaskill-Stevens W, Paskett ED. PMID: 28739629.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Anti-proliferative Effects of Nucleotides on Gastric Cancer via a Novel P2Y6/SOCE/Ca2+/ß-catenin Pathway. Sci Rep. 2017 05 26; 7(1):2459. Wan H, Xie R, Xu J, He J, Tang B, Liu Q, Wang S, Guo Y, Yang X, Dong TX, Carethers JM, Yang S, Dong H. PMID: 28550303.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Microsatellite Instability Pathway and EMAST in Colorectal Cancer. Curr Colorectal Cancer Rep. 2017 Feb; 13(1):73-80. Carethers JM. PMID: 28367107.
      View in: PubMed   Mentions:
    28. International Exchange and American Medicine. N Engl J Med. 2017 May 11; 376(19):e40. Armstrong K, Anderson ME, Carethers JM, Loscalzo J, Parmacek MS, Wachter RM, Zeidel ML. PMID: 28146413.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. The Increasing Incidence of Colorectal Cancers Diagnosed in Subjects Under Age 50 Among Races: CRaCking the Conundrum. Dig Dis Sci. 2016 10; 61(10):2767-2769. Carethers JM. PMID: 27480086.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLoS One. 2016; 11(6):e0156660. Basa RC, Davies V, Li X, Murali B, Shah J, Yang B, Li S, Khan MW, Tian M, Tejada R, Hassan A, Washington A, Mukherjee B, Carethers JM, McGuire KL. PMID: 27310868.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Facilitating Minority Medical Education, Research, and Faculty. Dig Dis Sci. 2016 06; 61(6):1436-9. Carethers JM. PMID: 26856718.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. GRG Profiles: John M. Carethers. Dig Dis Sci. 2016 06; 61(6):1429-35. Carethers JM. PMID: 26846119.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Gastroenterology 2011-2016: Looking Back and Forward. Gastroenterology. 2016 06; 150(7):1496-1502. Omary MB, Carethers JM, Owyang C. PMID: 27302536.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity. Clin Cancer Res. 2016 Nov 01; 22(21):5277-5286. Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, Kano Y, Nishikawa S, Fukusumi T, Takahashi Y, Hata T, Nishimura J, Takemasa I, Mizushima T, Ikenaga M, Kato T, Murata K, Carethers JM, Yamamoto H, Doki Y, Mori M. PMID: 27166395.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. Presentation of the Julius M. Friedenwald Medal to C. Richard Boland, MD, AGAF. Gastroenterology. 2016 06; 150(7):1673-1677. Carethers JM, Goel A. PMID: 27138978.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status. Cancer Biol Ther. 2016 07 02; 17(7):760-8. Suzuki S, Iwaizumi M, Tseng-Rogenski S, Hamaya Y, Miyajima H, Kanaoka S, Sugimoto K, Carethers JM. PMID: 27115207.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016 Apr 23; 7(23):34546-57. Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. PMID: 27120810.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    38. Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/ß-catenin signaling pathway. Cancer Lett. 2016 07 10; 377(1):44-54. Tang B, Chow JY, Dong TX, Yang SM, Lu DS, Carethers JM, Dong H. PMID: 27108064.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    39. Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis. Gastroenterology. 2016 Apr; 150(4):944-55. Koi M, Garcia M, Choi C, Kim HR, Koike J, Hemmi H, Nagasaka T, Okugawa Y, Toiyama Y, Kitajima T, Imaoka H, Kusunoki M, Chen YH, Mukherjee B, Boland CR, Carethers JM. PMID: 26752111.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. HEREDITARY, SPORADIC AND METASTATIC COLORECTAL CANCER ARE COMMONLY DRIVEN BY SPECIFIC SPECTRUMS OF DEFECTIVE DNA MISMATCH REPAIR COMPONENTS. Trans Am Clin Climatol Assoc. 2016; 127:81-97. Carethers JM. PMID: 28066040.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. Genetics, Genetic Testing, and Biomarkers of Digestive Diseases. Gastroenterology. 2015 Oct; 149(5):1131-3. Carethers JM, Braun J, Sands BE. PMID: 26327133.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Reducing colorectal cancer risk among African Americans. Gastroenterology. 2015 Nov; 149(6):1302-4. Kupfer SS, Carr RM, Carethers JM. PMID: 26302487.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer. World J Gastroenterol. 2015 Aug 21; 21(31):9253-61. Carethers JM, Stoffel EM. PMID: 26309352.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    44. Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer. Gastroenterology. 2015 Oct; 149(5):1177-1190.e3. Carethers JM, Jung BH. PMID: 26216840.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    45. Biomarker-directed Targeted Therapy in Colorectal Cancer. J Dig Cancer Rep. 2015 Jun; 3(1):5-10. Carethers JM. PMID: 26609516.
      View in: PubMed   Mentions:
    46. Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer. PLoS One. 2015; 10(5):e0127591. Hamaya Y, Guarinos C, Tseng-Rogenski SS, Iwaizumi M, Das R, Jover R, Castells A, Llor X, Andreu M, Carethers JM. PMID: 25996601.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    47. Martin F. Kagnoff, MD: 1941-2014. Mucosal Immunol. 2015 May; 8(3):441-3. Barrett KE, Eckmann L, Carethers JM. PMID: 25943415.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression. Genes (Basel). 2015 Mar 31; 6(2):185-205. Carethers JM, Koi M, Tseng-Rogenski SS. PMID: 25836926.
      View in: PubMed   Mentions: 28     Fields:    
    49. Martin F. Kagnoff, MD, January 19, 1941--November 16, 2014. Gastroenterology. 2015 Mar; 148(3):457-8. Eckmann L, Barrett KE, Carethers JM. PMID: 25620667.
      View in: PubMed   Mentions:    Fields:    
    50. Screening for colorectal cancer in African Americans: determinants and rationale for an earlier age to commence screening. Dig Dis Sci. 2015 Mar; 60(3):711-21. Carethers JM. PMID: 25540085.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansPHPublic Health
    51. Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome. Gastroenterology. 2015 Jan; 148(1):10-3. Fearon ER, Carethers JM. PMID: 25451650.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    52. Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. Gastroenterology. 2015 Mar; 148(3):579-89. Tseng-Rogenski SS, Hamaya Y, Choi DY, Carethers JM. PMID: 25461668.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    53. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. PMID: 25180532.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    54. Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer. PLoS One. 2014; 9(6):e100461. Carethers JM, Murali B, Yang B, Doctolero RT, Tajima A, Basa R, Smith EJ, Lee M, Janke R, Ngo T, Tejada R, Ji M, Kinseth M, Cabrera BL, Miyai K, Keku TO, Martin CF, Galanko JA, Sandler RS, McGuire KL. PMID: 24956473.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    55. Differentiating Lynch-like from Lynch syndrome. Gastroenterology. 2014 Mar; 146(3):602-4. Carethers JM. PMID: 24468183.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    56. The United States System for Training of Gastroenterologists in Oncology. J Dig Cancer Rep. 2014; 2(1):11-14. Carethers JM. PMID: 25584345.
      View in: PubMed   Mentions:
    57. DNA testing and molecular screening for colon cancer. Clin Gastroenterol Hepatol. 2014 Mar; 12(3):377-81. Carethers JM. PMID: 24355100.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    58. Current and Future Role of the Gastroenterologist in GI Cancer Management. J Dig Cancer Rep. 2013 Nov; 1(2):78-81. Carethers JM. PMID: 25506586.
      View in: PubMed   Mentions:
    59. Toward a comprehensive and systematic methylome signature in colorectal cancers. Epigenetics. 2013 Aug; 8(8):807-15. Ashktorab H, Rahi H, Wansley D, Varma S, Shokrani B, Lee E, Daremipouran M, Laiyemo A, Goel A, Carethers JM, Brim H. PMID: 23975090.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    60. Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity. Mutat Res. 2013 Jul-Aug; 747-748:19-27. Iwaizumi M, Tseng-Rogenski S, Carethers JM. PMID: 23643670.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    61. Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. PLoS One. 2012; 7(11):e50616. Tseng-Rogenski SS, Chung H, Wilk MB, Zhang S, Iwaizumi M, Carethers JM. PMID: 23226332.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    62. Bridging behavior and biology to reduce socioeconomic disparities in colorectal cancer risk. J Natl Cancer Inst. 2012 Sep 19; 104(18):1343-4. Ayanian JZ, Carethers JM. PMID: 22952312.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    63. Proteomics, genomics, and molecular biology in the personalized treatment of colorectal cancer. J Gastrointest Surg. 2012 Sep; 16(9):1648-50. Carethers JM. PMID: 22760966.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    64. Both hMutSa and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity. PLoS One. 2011; 6(12):e28117. Tajima A, Iwaizumi M, Tseng-Rogenski S, Cabrera BL, Carethers JM. PMID: 22164234.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. DNA mismatch repair proficiency executing 5-fluorouracil cytotoxicity in colorectal cancer cells. Cancer Biol Ther. 2011 Oct 15; 12(8):756-64. Iwaizumi M, Tseng-Rogenski S, Carethers JM. PMID: 21814034.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    66. Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2). Mutat Res. 2012 Jan 03; 729(1-2):73-80. Chung H, Chaudhry J, Lai JF, Young DJ, Carethers JM. PMID: 22001236.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    67. Microsatellite instability, EMAST, and morphology associations with T cell infiltration in colorectal neoplasia. Dig Dis Sci. 2012 Jan; 57(1):72-8. Lee SY, Miyai K, Han HS, Hwang DY, Seong MK, Chung H, Jung BH, Devaraj B, McGuire KL, Carethers JM. PMID: 21773681.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    68. One colon lumen but two organs. Gastroenterology. 2011 Aug; 141(2):411-2. Carethers JM. PMID: 21708155.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    69. John Cunningham virus T-antigen expression in anal carcinoma. Cancer. 2011 Jun 01; 117(11):2379-85. Ramamoorthy S, Devaraj B, Miyai K, Luo L, Liu YT, Boland CR, Goel A, Carethers JM. PMID: 24048785.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    70. Cyclin E and histone H3 levels are regulated by 5-fluorouracil in a DNA mismatch repair-dependent manner. Cancer Biol Ther. 2010 Dec 01; 10(11):1147-56. Chung H, Chaudhry J, Lopez CG, Carethers JM. PMID: 20930505.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    71. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb; 25(2):590-9. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. PMID: 20974669.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    72. Detection of multiple human papillomavirus genotypes in anal carcinoma. Infect Agent Cancer. 2010 Oct 12; 5:17. Ramamoorthy S, Liu YT, Luo L, Miyai K, Lu Q, Carethers JM. PMID: 20939896.
      View in: PubMed   Mentions:
    73. Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1493-503. Dong H, Shim KN, Li JM, Estrema C, Ornelas TA, Nguyen F, Liu S, Ramamoorthy SL, Ho S, Carethers JM, Chow JY. PMID: 20861471.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    74. Relationship of EMAST and microsatellite instability among patients with rectal cancer. J Gastrointest Surg. 2010 Oct; 14(10):1521-8. Devaraj B, Lee A, Cabrera BL, Miyai K, Luo L, Ramamoorthy S, Keku T, Sandler RS, McGuire KL, Carethers JM. PMID: 20844976.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    75. Evidence for an hMSH3 defect in familial hamartomatous polyps. Cancer. 2011 Feb 01; 117(3):492-500. Huang SC, Lee JK, Smith EJ, Doctolero RT, Tajima A, Beck SE, Weidner N, Carethers JM. PMID: 20845481.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    76. Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasias. Gastroenterology. 2010 Nov; 139(5):1519-25. Lee SY, Chung H, Devaraj B, Iwaizumi M, Han HS, Hwang DY, Seong MK, Jung BH, Carethers JM. PMID: 20708618.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    77. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 01; 21(13):2338-54. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. PMID: 20462955.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    78. Both microsatellite length and sequence context determine frameshift mutation rates in defective DNA mismatch repair. Hum Mol Genet. 2010 Jul 01; 19(13):2638-47. Chung H, Lopez CG, Holmstrom J, Young DJ, Lai JF, Ream-Robinson D, Carethers JM. PMID: 20418486.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    79. Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats. Clin Cancer Res. 2010 Mar 15; 16(6):1950-6. Campregher C, Honeder C, Chung H, Carethers JM, Gasche C. PMID: 20197483.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    80. Flanking sequence specificity determines coding microsatellite heteroduplex and mutation rates with defective DNA mismatch repair (MMR). Oncogene. 2010 Apr 15; 29(15):2172-80. Chung H, Lopez CG, Young DJ, Lai JF, Holmstrom J, Ream-Robinson D, Cabrera BL, Carethers JM. PMID: 20140012.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    81. Secondary Prevention of Colorectal Cancer: Is There an Optimal Follow-up for Patients with Colorectal Cancer? Curr Colorectal Cancer Rep. 2010 Jan; 6(1):24-29. Carethers JM. PMID: 20157368.
      View in: PubMed   Mentions:
    82. Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms. PLoS One. 2009 Dec 14; 4(12):e8308. Jung B, Gomez J, Chau E, Cabral J, Lee JK, Anselm A, Slowik P, Ream-Robinson D, Messer K, Sporn J, Shin SK, Boland CR, Goel A, Carethers JM. PMID: 20011542.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    83. TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G275-82. Chow JY, Ban M, Wu HL, Nguyen F, Huang M, Chung H, Dong H, Carethers JM. PMID: 19940030.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    84. Multiple "apple-core" lesions in chronic ischemic colitis: the great masquerader. Am J Gastroenterol. 2009 Nov; 104(11):2870-2. Ghosh P, Carethers JM. PMID: 19888260.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    85. ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding. Gastroenterol Res Pract. 2009; 2009:384506. Lee JK, Carethers JM, Ghosh P. PMID: 19753317.
      View in: PubMed   Mentions:
    86. The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease. Surg Endosc. 2010 Mar; 24(3):531-5. Ramamoorthy SL, Lee JK, Luo L, Mintz Y, Cullen J, Easter DW, Savu MK, Chock A, Carethers J, Horgan S, Talamini MA. PMID: 19688397.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    87. Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis. Gastroenterology. 2009 Jul; 137(1):33-6. Carethers JM. PMID: 19482104.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    88. TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells. Cancer Biol Ther. 2008 Oct; 7(10):1694-9. Chow JY, Cabral JA, Chang J, Carethers JM. PMID: 18769113.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    89. Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair. PLoS One. 2008; 3(10):e3463. Chung H, Young DJ, Lopez CG, Le TA, Lee JK, Ream-Robinson D, Huang SC, Carethers JM. PMID: 18941508.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    90. This month in Gastroenterology. Gastroenterology. 2008 Nov; 135(5):1435-8. Tack J, Carethers JM. PMID: 18848831.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    91. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology. 2008 Oct; 135(4):1079-99. Grady WM, Carethers JM. PMID: 18773902.
      View in: PubMed   Mentions: 309     Fields:    Translation:Humans
    92. Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma. World J Gastroenterol. 2008 Jul 21; 14(27):4389-94. Lee JK, Ghosh P, McWhorter V, Payne M, Olson R, Krinsky ML, Ramamoorthy S, Carethers JM. PMID: 18666331.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    93. Tobacco smoking and risk of recurrence for squamous cell cancer of the anus. Cancer Detect Prev. 2008; 32(2):116-20. Ramamoorthy S, Luo L, Luo E, Carethers JM. PMID: 18639388.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    94. Systemic treatment of advanced colorectal cancer: tailoring therapy to the tumor. Therap Adv Gastroenterol. 2008 Jul; 1(1):33-42. Carethers JM. PMID: 21180512.
      View in: PubMed   Mentions:
    95. This month in gastroenterology. Gastroenterology. 2008 Jul; 135(1):1-5. Tack J, Carethers JM. PMID: 18554514.
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    96. TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G899-905. Chow JY, Dong H, Quach KT, Van Nguyen PN, Chen K, Carethers JM. PMID: 18239055.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    97. Starting your first faculty position. Gastrointest Endosc. 2007 Dec; 66(6):1186-7. Carethers JM. PMID: 18061719.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    98. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology. 2007 Dec; 133(6):1849-57. Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. PMID: 18054557.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    99. BMP suppresses PTEN expression via RAS/ERK signaling. Cancer Biol Ther. 2007 Aug; 6(8):1313-7. Beck SE, Carethers JM. PMID: 18059158.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    100. The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside. Fam Cancer. 2008; 7(1):41-52. Boland CR, Koi M, Chang DK, Carethers JM. PMID: 17636426.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    101. RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis. 2007 Nov; 28(11):2321-7. Chow JY, Quach KT, Cabrera BL, Cabral JA, Beck SE, Carethers JM. PMID: 17638924.
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    102. Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A. J Pediatr Gastroenterol Nutr. 2007 Mar; 44(3):318-25. Kurland JE, Beck SE, Solomon CJ, Brann OS, Carethers JM, Huang SC. PMID: 17325551.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    103. BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. Cell Signal. 2007 Jul; 19(7):1465-72. Beck SE, Jung BH, Del Rosario E, Gomez J, Carethers JM. PMID: 17317101.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    104. Prospective evaluation of fluorouracil chemotherapy based on the genetic makeup of colorectal cancer. Gut. 2006 Dec; 55(12):1819. Carethers JM. PMID: 17124162.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    105. Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. Gastroenterology. 2007 Feb; 132(2):633-44. Jung BH, Beck SE, Cabral J, Chau E, Cabrera BL, Fiorino A, Smith EJ, Bocanegra M, Carethers JM. PMID: 17258738.
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    106. Symptomatic colonic spirochaetosis in an immunocompetent patient. J Clin Pathol. 2006 Oct; 59(10):1100-1. Lin RK, Miyai K, Carethers JM. PMID: 17021136.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    107. Bone morphogenetic protein signaling and growth suppression in colon cancer. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G135-45. Beck SE, Jung BH, Fiorino A, Gomez J, Rosario ED, Cabrera BL, Huang SC, Chow JY, Carethers JM. PMID: 16769811.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    108. Prospective evaluation of fluorouracil chemotherapy based on the genetic makeup of colorectal cancer. Gut. 2006 Jun; 55(6):759-61. Carethers JM. PMID: 16698750.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    109. Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. Int J Cancer. 2006 May 15; 118(10):2509-13. Jung B, Smith EJ, Doctolero RT, Gervaz P, Alonso JC, Miyai K, Keku T, Sandler RS, Carethers JM. PMID: 16380996.
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    110. Peritoneal mice implicated in intestinal obstruction: report of a case and review of the literature. J Clin Gastroenterol. 2006 May-Jun; 40(5):427-30. Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. PMID: 16721225.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    111. Chemotherapeutic implications in microsatellite unstable colorectal cancer. Cancer Biomark. 2006; 2(1-2):51-60. Jo WS, Carethers JM. PMID: 17192059.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    112. Unwinding the heterogeneous nature of hamartomatous polyposis syndromes. JAMA. 2005 Nov 16; 294(19):2498-500. Carethers JM. PMID: 16287964.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    113. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer. 2005 Oct 10; 116(6):914-9. Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, Hylind L, Iacosozio-Dononue C, Carethers JM, Goel A, Boland CR, Giardiello FM. PMID: 15856472.
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    114. Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2253-6. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR. PMID: 16172239.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    115. Should African Americans be screened for colorectal cancer at an earlier age? Nat Clin Pract Gastroenterol Hepatol. 2005 Aug; 2(8):352-3. Carethers JM. PMID: 16265401.
      View in: PubMed   Mentions: 9     Fields:    
    116. 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer. Cancer Epidemiol Biomarkers Prev. 2005 Aug; 14(8):2023-9. Eaton AM, Sandler R, Carethers JM, Millikan RC, Galanko J, Keku TO. PMID: 16103455.
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    117. Quality of life and diet intervention in individuals at risk for recurrence of colorectal adenomas. Psychooncology. 2005 Feb; 14(2):85-93. Pakiz B, Flatt SW, Mills KC, Jordan LJ, Carethers JM, Rock CL. PMID: 15386785.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    118. Diet, lifestyle, and genomic instability in the North Carolina Colon Cancer Study. Cancer Epidemiol Biomarkers Prev. 2005 Feb; 14(2):429-36. Satia JA, Keku T, Galanko JA, Martin C, Doctolero RT, Tajima A, Sandler RS, Carethers JM. PMID: 15734969.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    119. The mismatch repair complex hMutS alpha recognizes 5-fluorouracil-modified DNA: implications for chemosensitivity and resistance. Gastroenterology. 2004 Dec; 127(6):1678-84. Tajima A, Hess MT, Cabrera BL, Kolodner RD, Carethers JM. PMID: 15578504.
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    120. Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps. Pediatr Res. 2005 Jan; 57(1):4-9; discussion 1-3. Iwamoto M, Hoffenberg EJ, Carethers JM, Doctolero R, Tajima A, Sugano K, Franklin WA, Ahnen DJ. PMID: 15557107.
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    121. NOD2 and colorectal cancer: guilt by non-association. Cancer Res. 2004 Aug 01; 64(15):5525; author reply 5525-6. Gasche C, Carethers JM. PMID: 15289364.
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    122. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004 May 01; 64(9):3014-21. Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. PMID: 15126336.
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    123. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology. 2004 Mar; 126(3):654-9. Jung B, Doctolero RT, Tajima A, Nguyen AK, Keku T, Sandler RS, Carethers JM. PMID: 14988818.
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    124. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology. 2004 Feb; 126(2):394-401. Carethers JM, Smith EJ, Behling CA, Nguyen L, Tajima A, Doctolero RT, Cabrera BL, Goel A, Arnold CA, Miyai K, Boland CR. PMID: 14762775.
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    125. Aphthous colitis in a young man with diverticulitis. Gastrointest Endosc. 2003 Aug; 58(2):301-4. Jung B, Carethers JM, Behling C, Garvie JJ. PMID: 12872111.
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    126. Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines. Cancer Lett. 2003 Jun 10; 195(2):243-51. Chang DK, Goel A, Ricciardiello L, Lee DH, Chang CL, Carethers JM, Boland CR. PMID: 12767533.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    127. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res. 2003 Apr 01; 63(7):1608-14. Goel A, Arnold CN, Niedzwiecki D, Chang DK, Ricciardiello L, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. PMID: 12670912.
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    128. High incidence of microsatellite instability in colorectal cancer from African Americans. Clin Cancer Res. 2003 Mar; 9(3):1112-7. Ashktorab H, Smoot DT, Carethers JM, Rahmanian M, Kittles R, Vosganian G, Doura M, Nidhiry E, Naab T, Momen B, Shakhani S, Giardiello FM, Shakhani S. PMID: 12631615.
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    129. Occult gastrointestinal bleeding and colonic mass lesion as initial presentation of renal cell carcinoma. J Clin Gastroenterol. 2002 Nov-Dec; 35(5):410-2. Pompa DJ, Carethers JM. PMID: 12394233.
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    130. Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol. 2002 Jul; 283(1):C148-54. Chang CL, Marra G, Chauhan DP, Ha HT, Chang DK, Ricciardiello L, Randolph A, Carethers JM, Boland CR. PMID: 12055083.
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    131. Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer. Surgery. 2002 Feb; 131(2):190-7. Gervaz P, Cerottini JP, Bouzourene H, Hahnloser D, Doan CL, Benhattar J, Chaubert P, Secic M, Gillet M, Carethers JM. PMID: 11854698.
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    132. Hamartomatous polyposis syndromes: genetic pathways. Curr Opin Gastroenterol. 2002 Jan; 18(1):60-7. Carethers JM. PMID: 17031232.
      View in: PubMed   Mentions: 1     Fields:    
    133. Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. Dis Colon Rectum. 2001 Oct; 44(10):1503-8. Gervaz P, Efron J, Poza AA, Chun SW, Pham TT, Woodhouse S, Wexner SD, Carethers JM. PMID: 11598481.
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    134. Intramural duodenal hematoma presenting as a complication of peptic ulcer disease. J Clin Gastroenterol. 2001 Jul; 33(1):53-5. Ahn MS, Miyai K, Carethers JM. PMID: 11418792.
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    135. Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. J Pediatr. 2001 May; 138(5):629-35. Huang SC, Lavine JE, Boland PS, Newbury RO, Kolodner R, Pham TT, Arnold CN, Boland CR, Carethers JM. PMID: 11343035.
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    136. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res. 2001 Mar 15; 61(6):2676-83. Yashiro M, Carethers JM, Laghi L, Saito K, Slezak P, Jaramillo E, Rubio C, Koizumi K, Hirakawa K, Boland CR. PMID: 11289147.
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    137. Human pancreatic adenocarcinomas express parathyroid hormone-related protein. J Clin Endocrinol Metab. 2001 Jan; 86(1):310-6. Bouvet M, Nardin SR, Burton DW, Behling C, Carethers JM, Moossa AR, Deftos LJ. PMID: 11232017.
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    138. Genetic heterogeneity in familial juvenile polyposis. Cancer Res. 2000 Dec 15; 60(24):6882-5. Huang SC, Chen CR, Lavine JE, Taylor SF, Newbury RO, Pham TT, Ricciardiello L, Carethers JM. PMID: 11156385.
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    139. Antisense inhibition of hMLH1 is not sufficient for loss of DNA mismatch repair function in the HCT116+chromosome 3 cell line. Clin Cancer Res. 2000 Oct; 6(10):3827-31. Chauhan DP, Yang Q, Carethers JM, Marra G, Chang CL, Chamberlain SM, Boland CR. PMID: 11051225.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    140. Colorectal cancer prevention and treatment. Gastroenterology. 2000 Feb; 118(2 Suppl 1):S115-28. Boland CR, Sinicrope FA, Brenner DE, Carethers JM. PMID: 10868902.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    141. Mutations of transforming growth factor beta 1 type II receptor, BAX, and insulin-like growth factor II receptor genes in microsatellite unstable cell lines. In Vivo. 2000 Jan-Feb; 14(1):13-20. Carethers JM, Pham TT. PMID: 10757056.
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    142. Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology. 1999 Jul; 117(1):123-31. Carethers JM, Chauhan DP, Fink D, Nebel S, Bresalier RS, Howell SB, Boland CR. PMID: 10381918.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    143. Racial and ethnic factors in the genetic pathogenesis of colorectal cancer. J Assoc Acad Minor Phys. 1999; 10(3):59-67. Carethers JM. PMID: 10826011.
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    144. Cell checkpoints and enterocyte differentiation: a recipe for sequential stages focus on "Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4". Am J Physiol. 1998 11; 275(5):C1191-2. Carethers JM. PMID: 9814965.
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    145. Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6. Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland CR. PMID: 9661881.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    146. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology. 1998 Jun; 114(6):1188-95. Carethers JM, Hawn MT, Greenson JK, Hitchcock CL, Boland CR. PMID: 9609755.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    147. Genetic instability and chromosomal aberrations in colorectal cancer: a review of the current models. Cancer Detect Prev. 1998; 22(5):377-82. Boland CR, Sato J, Saito K, Carethers JM, Marra G, Laghi L, Chauhan DP. PMID: 9727618.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    148. Localization of the Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23. Gastroenterology. 1997 Nov; 113(5):1433-7. Zigman AF, Lavine JE, Jones MC, Boland CR, Carethers JM. PMID: 9352843.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    149. The cellular and molecular pathogenesis of colorectal cancer. Gastroenterol Clin North Am. 1996 Dec; 25(4):737-54. Carethers JM. PMID: 8960890.
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    150. Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. J Clin Gastroenterol. 1996 Jul; 23(1):55-9. Carethers JM, McDonnell WM, Owyang C, Scheiman JM. PMID: 8835903.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    151. Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Clin Invest. 1996 Jul 01; 98(1):199-206. Carethers JM, Hawn MT, Chauhan DP, Luce MC, Marra G, Koi M, Boland CR. PMID: 8690794.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    152. In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer. Gastroenterology. 1995 Oct; 109(4):1368-74. Luce MC, Marra G, Chauhan DP, Laghi L, Carethers JM, Cherian SP, Hawn M, Binnie CG, Kam-Morgan LN, Cayouette MC. PMID: 7557107.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    153. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res. 1995 Sep 01; 55(17):3721-5. Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, Boland CR, Koi M. PMID: 7641183.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    154. Delayed gastric emptying after laparoscopic anterior highly selective and posterior truncal vagotomy. Am J Gastroenterol. 1995 May; 90(5):810-1. Tobi M, Holtz T, Carethers J, Owyang C. PMID: 7733092.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    155. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 1994 Aug 15; 54(16):4308-12. Koi M, Umar A, Chauhan DP, Cherian SP, Carethers JM, Kunkel TA, Boland CR. PMID: 8044777.
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    156. Images in clinical medicine. Extraintestinal manifestations of Crohn's disease. N Engl J Med. 1994 Jun 30; 330(26):1870. Carethers JM, McDonnell WM. PMID: 8196730.
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