Johannes Karges

Title(s)Postdoctoral Scholar, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-5258-0260 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Philipps-University, Marburg, Germany Bachelor of Science2014Chemistry
    Imperial College, London, United KingdomErasmus Exchange2015Chemistry
    Philipps-University, Marburg, Germany Master of Science2016Chemistry
    Sun Yat-sen University, Guangzhou, ChinaPhD Exchange2019Bioinorganic Chemistry
    École Nationale Supérieure de Chimie de Paris - Université Paris Sciences et Lettres, Paris, FrancePhD2020Bioinorganic Chemistry
    Collapse Awards and Honors
    2014  - 2015Erasmus Scholarship
    2015  - 2016 Deutschlandstipendium Scholarship
    2020Reaxys PhD Prize
    2020René Dabard – ENSCR Award

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chiral rhodium(III)-azobenzene complexes as photoswitchable DNA molecular locks. Chem Commun (Camb). 2022 Mar 31; 58(27):4324-4327. Lin M, Zou S, Li T, Karges J, Chen Y, Zhao Y, Ji L, Chao H. PMID: 35274116.
      View in: PubMed   Mentions:
    2. Photo-Reduction with NIR Light of Nucleus-Targeting PtIV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy. Angew Chem Int Ed Engl. 2022 May 09; 61(20):e202201486. Wei D, Huang Y, Wang B, Ma L, Karges J, Xiao H. PMID: 35212437.
      View in: PubMed   Mentions:
    3. Combination of chemistry and material science to overcome health problems. Biosaf Health. 2022 Mar 09. Karges J. PMID: 35284813; PMCID: PMC8906073.
      View in: PubMed   Mentions:
    4. Computational Prediction of the Binding Pose of Metal-Binding Pharmacophores. ACS Med Chem Lett. 2022 Mar 10; 13(3):428-435. Karges J, Stokes RW, Cohen SM. PMID: 35300086; PMCID: PMC8919381.
      View in: PubMed   Mentions:
    5. Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia. J Am Chem Soc. 2022 03 09; 144(9):4091-4101. Kuang S, Wei F, Karges J, Ke L, Xiong K, Liao X, Gasser G, Ji L, Chao H. PMID: 35171598.
      View in: PubMed   Mentions:
    6. Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition. Chem Sci. 2022 Feb 16; 13(7):2128-2136. Jackl MK, Seo H, Karges J, Kalaj M, Cohen SM. PMID: 35308862; PMCID: PMC8849047.
      View in: PubMed   Mentions:
    7. Clinical Development of Metal Complexes as Photosensitizers for Photodynamic Therapy of Cancer. Angew Chem Int Ed Engl. 2022 01 26; 61(5):e202112236. Karges J. PMID: 34748690.
      View in: PubMed   Mentions:
    8. Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro. Chemistry. 2021 Dec 20; 27(71):17928-17940. Gil-Moles M, Türck S, Basu U, Pettenuzzo A, Bhattacharya S, Rajan A, Ma X, Büssing R, Wölker J, Burmeister H, Hoffmeister H, Schneeberg P, Prause A, Lippmann P, Kusi-Nimarko J, Hassell-Hart S, McGown A, Guest D, Lin Y, Notaro A, Vinck R, Karges J, Cariou K, Peng K, Qin X, Wang X, Skiba J, Szczupak L, Kowalski K, Schatzschneider U, Hemmert C, Gornitzka H, Milaeva ER, Nazarov AA, Gasser G, Spencer J, Ronconi L, Kortz U, Cinatl J, Bojkova D, Ott I, Gil-Moles M, Türck S, Basu U, Pettenuzzo A, Bhattacharya S, Rajan A, Ma X, Büssing R, Wölker J, Burmeister H, Hoffmeister H, Schneeberg P, Prause A, Lippmann P, Kusi-Nimarko J, Hassell-Hart S, McGown A, Guest D, Lin Y, Notaro A, Vinck R, Karges J, Cariou K, Peng K, Qin X, Wang X, Skiba J, Szczupak L, Kowalski K, Schatzschneider U, Hemmert C, Gornitzka H, Milaeva ER, Nazarov AA, Gasser G, Spencer J, Ronconi L, Kortz U, Cinatl J, Bojkova D, Ott I. PMID: 34714566; PMCID: PMC8653295.
      View in: PubMed   Mentions:
    9. Synthesis of tetranuclear rhenium(I) tricarbonyl metallacycles. Dalton Trans. 2021 Nov 16; 50(44):16147-16155. Karges J, Seo H, Cohen SM. PMID: 34679156.
      View in: PubMed   Mentions:    Fields:    
    10. A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy. RSC Chem Biol. 2022 Jan 05; 3(1):85-95. McKenzie LK, Flamme M, Felder PS, Karges J, Bonhomme F, Gandioso A, Malosse C, Gasser G, Hollenstein M. PMID: 35128412; PMCID: PMC8729177.
      View in: PubMed   Mentions:
    11. Physical, spectroscopic, and biological properties of ruthenium and osmium photosensitizers bearing diversely substituted 4,4'-di(styryl)-2,2'-bipyridine ligands. Dalton Trans. 2021 Oct 26; 50(41):14629-14639. Vinck R, Karges J, Tharaud M, Cariou K, Gasser G. PMID: 34581373.
      View in: PubMed   Mentions:    Fields:    
    12. Evaluating Metal-Ligand Interactions of Metal-Binding Isosteres Using Model Complexes. Inorg Chem. 2021 Nov 15; 60(22):17161-17172. Seo H, Prosser KE, Kalaj M, Karges J, Dick BL, Cohen SM. PMID: 34699201; PMCID: PMC8846946.
      View in: PubMed   Mentions:
    13. Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells. ACS Appl Mater Interfaces. 2021 Aug 25; 13(33):38959-38968. Xiong K, Zhou Y, Karges J, Du K, Shen J, Lin M, Wei F, Kou J, Chen Y, Ji L, Chao H. PMID: 34379404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Corrigendum: ReI Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease. Angew Chem Int Ed Engl. 2021 Jul 26; 60(31):16740. Karges J, Kalaj M, Gembicky M, Cohen SM. PMID: 34278669; PMCID: PMC8426708.
      View in: PubMed   Mentions:    Fields:    
    15. Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for hierarchical-targeted synergistic NIR-II photothermal and sonodynamic therapy. Biomaterials. 2021 08; 275:120979. Shen J, Karges J, Xiong K, Chen Y, Ji L, Chao H. PMID: 34166910.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Metal Complexes as Antiviral Agents for SARS-CoV-2. Chembiochem. 2021 08 17; 22(16):2600-2607. Karges J, Cohen SM. PMID: 34002456; PMCID: PMC8239769.
      View in: PubMed   Mentions:    Fields:    
    17. Ru(II) Polypyridine Complex-Functionalized Mesoporous Silica Nanoparticles as Photosensitizers for Cancer Targeted Photodynamic Therapy. ACS Appl Bio Mater. 2021 05 17; 4(5):4394-4405. Karges J, Díaz-García D, Prashar S, Gómez-Ruiz S, Gasser G. PMID: 35006851.
      View in: PubMed   Mentions:
    18. Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers. J Med Chem. 2021 04 22; 64(8):4612-4622. Karges J, Tharaud M, Gasser G. PMID: 33818111.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. ReI Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease. Angew Chem Int Ed Engl. 2021 05 03; 60(19):10716-10723. Karges J, Kalaj M, Gembicky M, Cohen SM. PMID: 33606889; PMCID: PMC8014511.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Photorelease of a metal-binding pharmacophore from a Ru(II) polypyridine complex. Dalton Trans. 2021 Mar 02; 50(8):2757-2765. Karges J, Stokes RW, Cohen SM. PMID: 33564808; PMCID: PMC7944940.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    21. Highly Cytotoxic Copper(II) Terpyridine Complexes as Anticancer Drug Candidates. Inorganica Chim. Acta. 2021; 516:120137. . View Publication.
    22. Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy. ACS Appl Mater Interfaces. 2020 Dec 09; 12(49):54433-54444. Karges J, Li J, Zeng L, Chao H, Gasser G. PMID: 33238711.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    23. One- and Two-Photon Phototherapeutic Effects of RuII Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumor Spheroids and Tumor-Bearing Mice*. Chemistry. 2021 Jan 04; 27(1):362-370. Karges J, Kuang S, Ong YC, Chao H, Gasser G. PMID: 32716591.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy. J Biol Inorg Chem. 2020 12; 25(8):1035-1050. Karges J, Chao H, Gasser G. PMID: 33146771.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Combining Inorganic Chemistry and Biology: The Underestimated Potential of Metal Complexes in Medicine. Chembiochem. 2020 11 02; 21(21):3044-3046. Karges J. PMID: 32896976.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    26. Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy. Nat Commun. 2020 06 26; 11(1):3262. Karges J, Kuang S, Maschietto F, Blacque O, Ciofini I, Chao H, Gasser G. PMID: 32591538; PMCID: PMC7320011.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans. 2020 May 26; 49(20):6616-6626. Lin Y, Ong YC, Keller S, Karges J, Bouchene R, Manoury E, Blacque O, Müller J, Anghel N, Hemphill A, Häberli C, Taki AC, Gasser RB, Cariou K, Keiser J, Gasser G. PMID: 32347259.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy. J Am Chem Soc. 2020 04 08; 142(14):6578-6587. Karges J, Heinemann F, Jakubaszek M, Maschietto F, Subecz C, Dotou M, Vinck R, Blacque O, Tharaud M, Goud B, Viñuelas Zahi Nos E, Spingler B, Ciofini I, Gasser G. PMID: 32172564.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. A Multi-action and Multi-target RuII -PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers. Angew Chem Int Ed Engl. 2020 04 27; 59(18):7069-7075. Karges J, Yempala T, Tharaud M, Gibson D, Gasser G. PMID: 32017379.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer. Chem Sci. 2020 Jan 30; 11(10):2657-2663. Soliman N, McKenzie LK, Karges J, Bertrand E, Tharaud M, Jakubaszek M, Guérineau V, Goud B, Hollenstein M, Gasser G, Thomas CM. PMID: 34084324; PMCID: PMC8157674.
      View in: PubMed   Mentions:
    31. Ruthenium-Initiated Polymerization of Lactide A Route to Remarkable Cellular Uptake for Photodynamic Therapy of Cancer. Chem. Sci. 2020; 11:2657-2663. . View Publication.
    32. Metal Dipyrrin Complexes as Potential Photosensitizers for Photodynamic Therapy. Inorganica Chim. Acta. 2020; 505:119482. . View Publication.
    33. Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy. Inorganica Chim. Acta. 2020; 499:119196. . View Publication.
    34. Polymeric Encapsulation of a Ru(II) Polypyridine Complex with Pluronic F‐127 for Photodynamic Therapy. Eur. J. Inorg. Chem. 2020; 2020:3242-3248. . View Publication.
    35. Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy. Chembiochem. 2020 02 17; 21(4):531-542. Karges J, Jakubaszek M, Mari C, Zarschler K, Goud B, Stephan H, Gasser G. PMID: 31339225; PMCID: PMC7065149.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    36. Towards Light-Activated Ruthenium-Arene (RAPTA-Type) Prodrug Candidates. Chembiochem. 2019 11 18; 20(22):2876-2882. Renfrew AK, Karges J, Scopelliti R, Bobbink FD, Nowak-Sliwinska P, Gasser G, Dyson PJ. PMID: 31102568.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells. Inorg Chem. 2019 Sep 16; 58(18):12422-12432. Karges J, Blacque O, Chao H, Gasser G. PMID: 31483641.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    38. Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers. Angew Chem Int Ed Engl. 2019 10 01; 58(40):14334-14340. Karges J, Basu U, Blacque O, Chao H, Gasser G. PMID: 31386250.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes. J Inorg Biochem. 2019 09; 198:110752. Karges J, Blacque O, Jakubaszek M, Goud B, Goldner P, Gasser G. PMID: 31242458.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers. Bioorg Med Chem. 2019 06 15; 27(12):2666-2675. Karges J, Heinemann F, Maschietto F, Patra M, Blacque O, Ciofini I, Spingler B, Gasser G. PMID: 31103403.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. Mesoporous silica nanoparticles functionalised with a photoactive ruthenium(ii) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser. Dalton Trans. 2019 May 07; 48(18):5940-5951. Ellahioui Y, Patra M, Mari C, Kaabi R, Karges J, Gasser G, Gómez-Ruiz S. PMID: 30209497.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    42. Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes. Inorganics. 2019; 7:4. . View Publication.
    43. Investigation of photo-activation on Ruthenium(II)-arene complexes for the discovery of potential selective cytotoxic agents. Polyhedron. 2019; 172:22-27. . View Publication.
    44. Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitisers for Photodynamic Therapy. Helv. Chim. Acta. 2019; 102:e1900104. . View Publication.
    45. Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3]2+ Core. Eur. J. Inorg. Chem. 2019; 2019:3704-3712. . View Publication.
    46. Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy. Acc Chem Res. 2017 11 21; 50(11):2727-2736. Heinemann F, Karges J, Gasser G. PMID: 29058879.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    47. Photoionization Yields in Intense fs-Laser Fields – A Systematic Investigation of Chirp Effects. Z. Phys. Chem. 2015; 229:1729-1746. Reusch N, Griebe S, Karges J, Weitzel K M. View Publication.
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