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Chiral rhodium(III)-azobenzene complexes as photoswitchable DNA molecular locks. Chem Commun (Camb). 2022 Mar 31; 58(27):4324-4327.
Lin M, Zou S, Li T, Karges J, Chen Y, Zhao Y, Ji L, Chao H. PMID: 35274116.
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Photo-Reduction with NIR Light of Nucleus-Targeting PtIV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy. Angew Chem Int Ed Engl. 2022 May 09; 61(20):e202201486.
Wei D, Huang Y, Wang B, Ma L, Karges J, Xiao H. PMID: 35212437.
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Combination of chemistry and material science to overcome health problems. Biosaf Health. 2022 Mar 09.
Karges J. PMID: 35284813; PMCID: PMC8906073.
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Computational Prediction of the Binding Pose of Metal-Binding Pharmacophores. ACS Med Chem Lett. 2022 Mar 10; 13(3):428-435.
Karges J, Stokes RW, Cohen SM. PMID: 35300086; PMCID: PMC8919381.
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Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia. J Am Chem Soc. 2022 03 09; 144(9):4091-4101.
Kuang S, Wei F, Karges J, Ke L, Xiong K, Liao X, Gasser G, Ji L, Chao H. PMID: 35171598.
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Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition. Chem Sci. 2022 Feb 16; 13(7):2128-2136.
Jackl MK, Seo H, Karges J, Kalaj M, Cohen SM. PMID: 35308862; PMCID: PMC8849047.
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Clinical Development of Metal Complexes as Photosensitizers for Photodynamic Therapy of Cancer. Angew Chem Int Ed Engl. 2022 01 26; 61(5):e202112236.
Karges J. PMID: 34748690.
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Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro. Chemistry. 2021 Dec 20; 27(71):17928-17940.
Gil-Moles M, Türck S, Basu U, Pettenuzzo A, Bhattacharya S, Rajan A, Ma X, Büssing R, Wölker J, Burmeister H, Hoffmeister H, Schneeberg P, Prause A, Lippmann P, Kusi-Nimarko J, Hassell-Hart S, McGown A, Guest D, Lin Y, Notaro A, Vinck R, Karges J, Cariou K, Peng K, Qin X, Wang X, Skiba J, Szczupak L, Kowalski K, Schatzschneider U, Hemmert C, Gornitzka H, Milaeva ER, Nazarov AA, Gasser G, Spencer J, Ronconi L, Kortz U, Cinatl J, Bojkova D, Ott I, Gil-Moles M, Türck S, Basu U, Pettenuzzo A, Bhattacharya S, Rajan A, Ma X, Büssing R, Wölker J, Burmeister H, Hoffmeister H, Schneeberg P, Prause A, Lippmann P, Kusi-Nimarko J, Hassell-Hart S, McGown A, Guest D, Lin Y, Notaro A, Vinck R, Karges J, Cariou K, Peng K, Qin X, Wang X, Skiba J, Szczupak L, Kowalski K, Schatzschneider U, Hemmert C, Gornitzka H, Milaeva ER, Nazarov AA, Gasser G, Spencer J, Ronconi L, Kortz U, Cinatl J, Bojkova D, Ott I. PMID: 34714566; PMCID: PMC8653295.
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Synthesis of tetranuclear rhenium(I) tricarbonyl metallacycles. Dalton Trans. 2021 Nov 16; 50(44):16147-16155.
Karges J, Seo H, Cohen SM. PMID: 34679156.
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A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy. RSC Chem Biol. 2022 Jan 05; 3(1):85-95.
McKenzie LK, Flamme M, Felder PS, Karges J, Bonhomme F, Gandioso A, Malosse C, Gasser G, Hollenstein M. PMID: 35128412; PMCID: PMC8729177.
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Physical, spectroscopic, and biological properties of ruthenium and osmium photosensitizers bearing diversely substituted 4,4'-di(styryl)-2,2'-bipyridine ligands. Dalton Trans. 2021 Oct 26; 50(41):14629-14639.
Vinck R, Karges J, Tharaud M, Cariou K, Gasser G. PMID: 34581373.
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Evaluating Metal-Ligand Interactions of Metal-Binding Isosteres Using Model Complexes. Inorg Chem. 2021 Nov 15; 60(22):17161-17172.
Seo H, Prosser KE, Kalaj M, Karges J, Dick BL, Cohen SM. PMID: 34699201; PMCID: PMC8846946.
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Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells. ACS Appl Mater Interfaces. 2021 Aug 25; 13(33):38959-38968.
Xiong K, Zhou Y, Karges J, Du K, Shen J, Lin M, Wei F, Kou J, Chen Y, Ji L, Chao H. PMID: 34379404.
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HumansAnimalsCells
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Corrigendum: ReI Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease. Angew Chem Int Ed Engl. 2021 Jul 26; 60(31):16740.
Karges J, Kalaj M, Gembicky M, Cohen SM. PMID: 34278669; PMCID: PMC8426708.
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Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for hierarchical-targeted synergistic NIR-II photothermal and sonodynamic therapy. Biomaterials. 2021 08; 275:120979.
Shen J, Karges J, Xiong K, Chen Y, Ji L, Chao H. PMID: 34166910.
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AnimalsCells
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Metal Complexes as Antiviral Agents for SARS-CoV-2. Chembiochem. 2021 08 17; 22(16):2600-2607.
Karges J, Cohen SM. PMID: 34002456; PMCID: PMC8239769.
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Ru(II) Polypyridine Complex-Functionalized Mesoporous Silica Nanoparticles as Photosensitizers for Cancer Targeted Photodynamic Therapy. ACS Appl Bio Mater. 2021 05 17; 4(5):4394-4405.
Karges J, Díaz-García D, Prashar S, Gómez-Ruiz S, Gasser G. PMID: 35006851.
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Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers. J Med Chem. 2021 04 22; 64(8):4612-4622.
Karges J, Tharaud M, Gasser G. PMID: 33818111.
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1 Fields:
Translation:
HumansCells
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ReI Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease. Angew Chem Int Ed Engl. 2021 05 03; 60(19):10716-10723.
Karges J, Kalaj M, Gembicky M, Cohen SM. PMID: 33606889; PMCID: PMC8014511.
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1 Fields:
Translation:
Humans
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Photorelease of a metal-binding pharmacophore from a Ru(II) polypyridine complex. Dalton Trans. 2021 Mar 02; 50(8):2757-2765.
Karges J, Stokes RW, Cohen SM. PMID: 33564808; PMCID: PMC7944940.
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Cells
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Highly Cytotoxic Copper(II) Terpyridine Complexes as Anticancer Drug Candidates. Inorganica Chim. Acta. 2021; 516:120137.
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Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy. ACS Appl Mater Interfaces. 2020 Dec 09; 12(49):54433-54444.
Karges J, Li J, Zeng L, Chao H, Gasser G. PMID: 33238711.
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1 Fields:
Translation:
HumansAnimalsCells
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One- and Two-Photon Phototherapeutic Effects of RuII Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumor Spheroids and Tumor-Bearing Mice*. Chemistry. 2021 Jan 04; 27(1):362-370.
Karges J, Kuang S, Ong YC, Chao H, Gasser G. PMID: 32716591.
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1 Fields:
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HumansAnimalsCells
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Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy. J Biol Inorg Chem. 2020 12; 25(8):1035-1050.
Karges J, Chao H, Gasser G. PMID: 33146771.
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Humans
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Combining Inorganic Chemistry and Biology: The Underestimated Potential of Metal Complexes in Medicine. Chembiochem. 2020 11 02; 21(21):3044-3046.
Karges J. PMID: 32896976.
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2 Fields:
Translation:
HumansAnimals
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Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy. Nat Commun. 2020 06 26; 11(1):3262.
Karges J, Kuang S, Maschietto F, Blacque O, Ciofini I, Chao H, Gasser G. PMID: 32591538; PMCID: PMC7320011.
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10 Fields:
Translation:
HumansAnimalsCells
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Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans. 2020 May 26; 49(20):6616-6626.
Lin Y, Ong YC, Keller S, Karges J, Bouchene R, Manoury E, Blacque O, Müller J, Anghel N, Hemphill A, Häberli C, Taki AC, Gasser RB, Cariou K, Keiser J, Gasser G. PMID: 32347259.
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AnimalsCells
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Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy. J Am Chem Soc. 2020 04 08; 142(14):6578-6587.
Karges J, Heinemann F, Jakubaszek M, Maschietto F, Subecz C, Dotou M, Vinck R, Blacque O, Tharaud M, Goud B, Viñuelas Zahi Nos E, Spingler B, Ciofini I, Gasser G. PMID: 32172564.
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6 Fields:
Translation:
Humans
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A Multi-action and Multi-target RuII -PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers. Angew Chem Int Ed Engl. 2020 04 27; 59(18):7069-7075.
Karges J, Yempala T, Tharaud M, Gibson D, Gasser G. PMID: 32017379.
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7 Fields:
Translation:
HumansCells
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Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer. Chem Sci. 2020 Jan 30; 11(10):2657-2663.
Soliman N, McKenzie LK, Karges J, Bertrand E, Tharaud M, Jakubaszek M, Guérineau V, Goud B, Hollenstein M, Gasser G, Thomas CM. PMID: 34084324; PMCID: PMC8157674.
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Ruthenium-Initiated Polymerization of Lactide A Route to Remarkable Cellular Uptake for Photodynamic Therapy of Cancer. Chem. Sci. 2020; 11:2657-2663.
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Metal Dipyrrin Complexes as Potential Photosensitizers for Photodynamic Therapy. Inorganica Chim. Acta. 2020; 505:119482.
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Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy. Inorganica Chim. Acta. 2020; 499:119196.
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Polymeric Encapsulation of a Ru(II) Polypyridine Complex with Pluronic F‐127 for Photodynamic Therapy. Eur. J. Inorg. Chem. 2020; 2020:3242-3248.
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Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy. Chembiochem. 2020 02 17; 21(4):531-542.
Karges J, Jakubaszek M, Mari C, Zarschler K, Goud B, Stephan H, Gasser G. PMID: 31339225; PMCID: PMC7065149.
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6 Fields:
Translation:
HumansCells
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Towards Light-Activated Ruthenium-Arene (RAPTA-Type) Prodrug Candidates. Chembiochem. 2019 11 18; 20(22):2876-2882.
Renfrew AK, Karges J, Scopelliti R, Bobbink FD, Nowak-Sliwinska P, Gasser G, Dyson PJ. PMID: 31102568.
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3 Fields:
Translation:
HumansCells
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Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells. Inorg Chem. 2019 Sep 16; 58(18):12422-12432.
Karges J, Blacque O, Chao H, Gasser G. PMID: 31483641.
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4 Fields:
Translation:
HumansCells
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Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers. Angew Chem Int Ed Engl. 2019 10 01; 58(40):14334-14340.
Karges J, Basu U, Blacque O, Chao H, Gasser G. PMID: 31386250.
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4 Fields:
Translation:
HumansCells
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Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes. J Inorg Biochem. 2019 09; 198:110752.
Karges J, Blacque O, Jakubaszek M, Goud B, Goldner P, Gasser G. PMID: 31242458.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers. Bioorg Med Chem. 2019 06 15; 27(12):2666-2675.
Karges J, Heinemann F, Maschietto F, Patra M, Blacque O, Ciofini I, Spingler B, Gasser G. PMID: 31103403.
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6 Fields:
Translation:
HumansCells
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Mesoporous silica nanoparticles functionalised with a photoactive ruthenium(ii) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser. Dalton Trans. 2019 May 07; 48(18):5940-5951.
Ellahioui Y, Patra M, Mari C, Kaabi R, Karges J, Gasser G, Gómez-Ruiz S. PMID: 30209497.
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14 Fields:
Translation:
HumansCells
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Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes. Inorganics. 2019; 7:4.
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Investigation of photo-activation on Ruthenium(II)-arene complexes for the discovery of potential selective cytotoxic agents. Polyhedron. 2019; 172:22-27.
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Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitisers for Photodynamic Therapy. Helv. Chim. Acta. 2019; 102:e1900104.
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Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3]2+ Core. Eur. J. Inorg. Chem. 2019; 2019:3704-3712.
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Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy. Acc Chem Res. 2017 11 21; 50(11):2727-2736.
Heinemann F, Karges J, Gasser G. PMID: 29058879.
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53 Fields:
Translation:
Humans
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Photoionization Yields in Intense fs-Laser Fields – A Systematic Investigation of Chirp Effects. Z. Phys. Chem. 2015; 229:1729-1746.
Reusch N, Griebe S, Karges J, Weitzel K M. View Publication.