Jeremy Rich

Title(s)Clinical Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-822-2703
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    Collapse Biography 
    Collapse Education and Training
    Duke University School of Medicine, Durham, NCMHS05/2009Clinical Research Training Program
    Baldwin Wallace University, Parma, OHMBA05/2016Health Care
    Duke University Medical Center, Durham, NC06/1998Neuro-Oncology
    Johns Hopkins Hospital, Baltimore, MD06/1997Neurology
    Johns Hopkins Hospital, Baltimore, MD06/1994Internal Medicine
    Duke University School of Medicine, Durham, NCMD05/1993Medicine
    Washington University, St. Louis, MOB.S.05/1989Electrical Engineering

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the Circadian Rhythm in Glioblastoma Stem Cells
    NIH R01CA238662Dec 1, 2019 - Nov 30, 2024
    Role: Principal Investigator
    Dual Targeting of Brain Tumor Initiating Cells through Inhibition of BMI1 and EZH2
    NIH R01NS103434Sep 30, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Dynamic Complexity of Brain Tumor Stem Cells
    NIH R35CA197718Aug 1, 2015 - Aug 31, 2022
    Role: Principal Investigator
    Instructive Cues in Glioblastoma Hierarchies
    NIH R01CA171652Aug 15, 2014 - Jul 31, 2015
    Role: Principal Investigator
    Energy Stress in Brain Tumor Initiating Stem Cells
    NIH R01NS089272Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Metabolism Informs Intertumoral & Intratumoral Heterogeneity
    NIH R01NS087913Apr 15, 2014 - Feb 28, 2019
    Role: Co-Principal Investigator
    Targeting Ferritin in Glioblastoma
    NIH R01CA169117Jul 1, 2013 - Apr 30, 2018
    Role: Co-Principal Investigator
    Targeting Brain Tumor Stem Cells Through Novel Therapeutic Combinations
    NIH R01CA154130Jul 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Stem Cell-Like Glioma Cells in Angiogenesis
    NIH R01CA129958Apr 7, 2008 - Dec 31, 2013
    Role: Principal Investigator
    TGFbeta-PTEN Interactions in Glioma Biology &Therapy
    NIH R01CA116659Aug 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    Molecular Mechanisms of SPARC Mediated Glioma Invasion
    NIH R01NS054276Feb 15, 2006 - Jan 31, 2011
    Role: Principal Investigator
    The Roles of Osteonectin and Osteoactivin in Gliomas
    NIH K02NS047409Jun 1, 2004 - Feb 28, 2009
    Role: Principal Investigator
    TGF beta and Brain Tumors
    NIH K08NS002055Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A delicate initiation: Lipolysis of lipid droplets fuels glioblastoma. Mol Cell. 2021 Jul 01; 81(13):2686-2687. Yang K, Rich JN. PMID: 34214442.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice. Sci Transl Med. 2021 06 30; 13(600). Fang X, Huang Z, Zhai K, Huang Q, Tao W, Kim L, Wu Q, Almasan A, Yu JS, Li X, Stark GR, Rich JN, Bao S. PMID: 34193614.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase. Nucleic Acids Res. 2021 Jun 28. Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q. PMID: 34181729.
      View in: PubMed   Mentions:    Fields:    
    4. Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches. Acta Neuropathol Commun. 2021 05 31; 9(1):101. Shakya S, Gromovsky AD, Hale JS, Knudsen AM, Prager B, Wallace LC, Penalva LOF, Brown HA, Kristensen BW, Rich JN, Lathia JD, Brown JM, Hubert CG. PMID: 34059134.
      View in: PubMed   Mentions: 1     Fields:    
    5. Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma. Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16). Kfoury N, Qi Z, Prager BC, Wilkinson MN, Broestl L, Berrett KC, Moudgil A, Sankararaman S, Chen X, Gertz J, Rich JN, Mitra RD, Rubin JB. PMID: 33850013.
      View in: PubMed   Mentions:    Fields:    
    6. PI3K? inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16). Li J, Kaneda MM, Ma J, Li M, Shepard RM, Patel K, Koga T, Sarver A, Furnari F, Xu B, Dhawan S, Ning J, Zhu H, Wu A, You G, Jiang T, Venteicher AS, Rich JN, Glass CK, Varner JA, Chen CC. PMID: 33846242.
      View in: PubMed   Mentions: 1     Fields:    
    7. Phage display targeting identifies EYA1 as a regulator of glioblastoma stem cell maintenance and proliferation. Stem Cells. 2021 Jul; 39(7):853-865. Kim J, She C, Potez M, Huang P, Wu Q, Prager BC, Qiu Z, Bao S, Rich JN, Liu JKC. PMID: 33594762.
      View in: PubMed   Mentions:    Fields:    
    8. Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs. Sci Adv. 2021 Feb; 7(9). Yang Z, Wang W, Zhao L, Wang X, Gimple RC, Xu L, Wang Y, Rich JN, Zhou S. PMID: 33627414.
      View in: PubMed   Mentions: 1     Fields:    
    9. Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade. JCI Insight. 2021 01 11; 6(1). Nair S, Mazzoccoli L, Jash A, Govero J, Bais SS, Hu T, Fontes-Garfias CR, Shan C, Okada H, Shresta S, Rich JN, Shi PY, Diamond MS, Chheda MG. PMID: 33232299.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells. Cell. 2021 Jan 21; 184(2):352-369.e23. Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck C. PMID: 33357448.
      View in: PubMed   Mentions: 1     Fields:    
    11. Protein sumoylation with SUMO1 promoted by Pin1 in glioma stem cells augments glioblastoma malignancy. Neuro Oncol. 2020 12 18; 22(12):1809-1821. Zhang A, Tao W, Zhai K, Fang X, Huang Z, Yu JS, Sloan AE, Rich JN, Zhou W, Bao S. PMID: 32592588.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Biomaterials and 3D Bioprinting Strategies to Model Glioblastoma and the Blood-Brain Barrier. Adv Mater. 2021 Feb; 33(5):e2004776. Tang M, Rich JN, Chen S. PMID: 33326131.
      View in: PubMed   Mentions:    Fields:    
    13. CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer Discov. 2021 May; 11(5):1192-1211. Wang D, Prager BC, Gimple RC, Aguilar B, Alizadeh D, Tang H, Lv D, Starr R, Brito A, Wu Q, Kim LJY, Qiu Z, Lin P, Lorenzini MH, Badie B, Forman SJ, Xie Q, Brown CE, Rich JN. PMID: 33328215.
      View in: PubMed   Mentions: 6     Fields:    
    14. Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose. J Virol. 2020 Dec 16. Clark AE, Zhu Z, Krach F, Rich JN, Yeo GW, Spector DH. PMID: 33328307.
      View in: PubMed   Mentions:    Fields:    
    15. Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33295-33304. Gao Y, Chen X, He Q, Gimple RC, Liao Y, Wang L, Wu R, Xie Q, Rich JN, Shen K, Yuan Z. PMID: 33318171.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO Mol Med. 2020 12 07; 12(12):e12291. Tao W, Zhang A, Zhai K, Huang Z, Huang H, Zhou W, Huang Q, Fang X, Prager BC, Wang X, Wu Q, Sloan AE, Ahluwalia MS, Lathia JD, Yu JS, Rich JN, Bao S. PMID: 33124191.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer Discov. 2021 Feb; 11(2):480-499. Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q, Qiu Z, Kidwell RL, Kim LJY, Xie Q, Vitting-Seerup K, Bhargava S, Dong Z, Jiang L, Zhu Z, Hamerlik P, Jaffrey SR, Zhao JC, Wang X, Rich JN. PMID: 33023892.
      View in: PubMed   Mentions: 13     Fields:    
    18. Reprogramming the microenvironment: tricks of tumor-derived astrocytes. Cell Res. 2020 08; 30(8):633-634. Zhang G, Rich JN. PMID: 32424205.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Cancer Discov. 2020 11; 10(11):1722-1741. Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN. PMID: 32703768.
      View in: PubMed   Mentions:    Fields:    
    20. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. N Engl J Med. 2020 07 09; 383(2):129-140. Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P, STRIDE Trial Investigators . PMID: 32640131.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nat Commun. 2020 06 15; 11(1):3015. Tao W, Chu C, Zhou W, Huang Z, Zhai K, Fang X, Huang Q, Zhang A, Wang X, Yu X, Huang H, Wu Q, Sloan AE, Yu JS, Li X, Stark GR, Rich JN, Bao S. PMID: 32541784.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Cell Res. 2020 10; 30(10):833-853. Tang M, Xie Q, Gimple RC, Zhong Z, Tam T, Tian J, Kidwell RL, Wu Q, Prager BC, Qiu Z, Yu A, Zhu Z, Mesci P, Jing H, Schimelman J, Wang P, Lee D, Lorenzini MH, Dixit D, Zhao L, Bhargava S, Miller TE, Wan X, Tang J, Sun B, Cravatt BF, Muotri AR, Chen S, Rich JN. PMID: 32499560.
      View in: PubMed   Mentions: 15     Fields:    
    23. Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell. 2020 06 11; 181(6):1329-1345.e24. Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD. PMID: 32445698.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    24. Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex-mediated STAT1 downregulation. J Exp Med. 2020 05 04; 217(5). Zhan X, Guo S, Li Y, Ran H, Huang H, Mi L, Wu J, Wang X, Xiao D, Chen L, Li D, Zhang S, Yan X, Yu Y, Li T, Han Q, He K, Cui J, Li T, Zhou T, Rich JN, Bao S, Zhang X, Li A, Man J. PMID: 32181805.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. Glioblastoma Stem Cells: Driving Resilience through Chaos. Trends Cancer. 2020 03; 6(3):223-235. Prager BC, Bhargava S, Mahadev V, Hubert CG, Rich JN. PMID: 32101725.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    26. Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. Cancer Discov. 2020 03; 10(3):382-393. Fan JB, Miyauchi S, Xu HZ, Liu D, Kim LJY, Burkart C, Cheng H, Arimoto KI, Yan M, Zhou Y, Gyorffy B, Knobeloch KP, Rich JN, Cang H, Fu XD, Zhang DE. PMID: 31974171.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin avß5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    28. Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Cell. 2019 11 27; 179(6):1330-1341.e13. Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, Allan KC, Mack SC, Wang X, Gimple RC, Wu Q, Rubin BP, Shetty S, Angers S, Dirks PB, Sallari RC, Lupien M, Rich JN, Scacheri PC. PMID: 31761532.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    29. Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma. Cancer Res. 2019 10 15; 79(20):5218-5232. Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM. PMID: 31488423.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    30. The dystroglycan receptor maintains glioma stem cells in the vascular niche. Acta Neuropathol. 2019 12; 138(6):1033-1052. Day BW, Lathia JD, Bruce ZC, D'Souza RCJ, Baumgartner U, Ensbey KS, Lim YC, Stringer BW, Akgül S, Offenhäuser C, Li Y, Jamieson PR, Smith FM, Jurd CLR, Robertson T, Inglis PL, Lwin Z, Jeffree RL, Johns TG, Bhat KPL, Rich JN, Campbell KP, Boyd AW. PMID: 31463571.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock. Cancer Discov. 2019 11; 9(11):1556-1573. Dong Z, Zhang G, Qu M, Gimple RC, Wu Q, Qiu Z, Prager BC, Wang X, Kim LJY, Morton AR, Dixit D, Zhou W, Huang H, Li B, Zhu Z, Bao S, Mack SC, Chavez L, Kay SA, Rich JN. PMID: 31455674.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    32. Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. Sci Transl Med. 2019 08 07; 11(504). Wang X, Yang K, Wu Q, Kim LJY, Morton AR, Gimple RC, Prager BC, Shi Y, Zhou W, Bhargava S, Zhu Z, Jiang L, Tao W, Qiu Z, Zhao L, Zhang G, Li X, Agnihotri S, Mischel PS, Mack SC, Bao S, Rich JN. PMID: 31391321.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'. Nat Rev Clin Oncol. 2019 08; 16(8):522-523. Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. PMID: 31150022.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Challenges to curing primary brain tumours. Nat Rev Clin Oncol. 2019 08; 16(8):509-520. Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. PMID: 30733593.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    35. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8. Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell. 2019 07 08; 36(1):51-67.e7. Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A. PMID: 31287992.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    37. Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. Cancer Discov. 2019 09; 9(9):1248-1267. Gimple RC, Kidwell RL, Kim LJY, Sun T, Gromovsky AD, Wu Q, Wolf M, Lv D, Bhargava S, Jiang L, Prager BC, Wang X, Ye Q, Zhu Z, Zhang G, Dong Z, Zhao L, Lee D, Bi J, Sloan AE, Mischel PS, Brown JM, Cang H, Huan T, Mack SC, Xie Q, Rich JN. PMID: 31201181.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    38. Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer. Genes Dev. 2019 06 01; 33(11-12):591-609. Gimple RC, Bhargava S, Dixit D, Rich JN. PMID: 31160393.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    39. Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells. Viruses. 2019 04 20; 11(4). Bernatchez JA, Coste M, Beck S, Wells GA, Luna LA, Clark AE, Zhu Z, Hecht D, Rich JN, Sohl CD, Purse BW, Siqueira-Neto JL. PMID: 31010044.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019 05 02; 24(5):707-723.e8. Weng Q, Wang J, Wang J, He D, Cheng Z, Zhang F, Verma R, Xu L, Dong X, Liao Y, He X, Potter A, Zhang L, Zhao C, Xin M, Zhou Q, Aronow BJ, Blackshear PJ, Rich JN, He Q, Zhou W, Suvà ML, Waclaw RR, Potter SS, Yu G, Lu QR. PMID: 30982771.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    41. Mechanism of Action of Methotrexate Against Zika Virus. Viruses. 2019 04 10; 11(4). Beck S, Zhu Z, Oliveira MF, Smith DM, Rich JN, Bernatchez JA, Siqueira-Neto JL. PMID: 30974762.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC. JCI Insight. 2019 04 04; 4(7). Zhang G, Dong Z, Prager BC, Kim LJ, Wu Q, Gimple RC, Wang X, Bao S, Hamerlik P, Rich JN. PMID: 30779712.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    43. Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma. J Exp Med. 2019 05 06; 216(5):1071-1090. Mack SC, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN. PMID: 30948495.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    44. SUFU: The Jekyll and Hyde of the Cerebellum. Dev Cell. 2019 01 28; 48(2):131-132. Kim LJY, Bhargava S, Gimple RC, Rich JN. PMID: 30695694.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Cancer Stem Cells: The Architects of the Tumor Ecosystem. Cell Stem Cell. 2019 01 03; 24(1):41-53. Prager BC, Xie Q, Bao S, Rich JN. PMID: 30609398.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    46. Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy. Stem Cells. 2019 01; 37(1):42-53. Jarrar A, Lotti F, DeVecchio J, Ferrandon S, Gantt G, Mace A, Karagkounis G, Orloff M, Venere M, Hitomi M, Lathia J, Rich JN, Kalady MF. PMID: 30353615.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    47. N6-methyladenine DNA Modification in Glioblastoma. Cell. 2018 11 15; 175(5):1228-1243.e20. Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, Dowiak AV, Lin K, Zeng C, Sui Y, Kim LJY, Miller TE, Jiang L, Lee CH, Huang Z, Fang X, Zhai K, Mack SC, Sander M, Bao S, Kerstetter-Fogle AE, Sloan AE, Xiao AZ, Rich JN. PMID: 30392959.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    48. Comparing costs of a senior wellness care redesign in group and independent physician practices of an accountable care organization. Int J Health Plann Manage. 2019 Jan; 34(1):241-250. Bustamante AV, Martinez A, Rich J, Chen X, Rodriguez HP. PMID: 30109902.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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    108. The tailless root of glioma: cancer stem cells. Cell Stem Cell. 2014 Aug 07; 15(2):114-6. Xie Q, Flavahan WA, Bao S, Rich J. PMID: 25105574.
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    109. The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. Stem Cells. 2014 Aug; 32(8):2033-47. Fang X, Huang Z, Zhou W, Wu Q, Sloan AE, Ouyang G, McLendon RE, Yu JS, Rich JN, Bao S. PMID: 24831540.
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    110. Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression. Stem Cells. 2014 Jul; 32(7):1746-58. Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD. PMID: 24737733.
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    111. Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells. Glia. 2014 Oct; 62(10):1687-98. Bai Y, Lathia JD, Zhang P, Flavahan W, Rich JN, Mattson MP. PMID: 24909307.
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    112. Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance. Mol Ther. 2014 Sep; 22(9):1678-87. Thorne AH, Meisen WH, Russell L, Yoo JY, Bolyard CM, Lathia JD, Rich J, Puduvalli VK, Mao H, Yu J, Caligiuri MA, Tridandapani S, Kaur B. PMID: 24895995.
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    113. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest. 2014 Jul; 124(7):2861-76. Ferrarese R, Harsh GR, Yadav AK, Bug E, Maticzka D, Reichardt W, Dombrowski SM, Miller TE, Masilamani AP, Dai F, Kim H, Hadler M, Scholtens DM, Yu IL, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte CW, He X, Prinz M, Chandler JP, Vogel H, Chakravarti A, Rich JN, Carro MS, Bredel M. PMID: 24865424.
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    114. Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes Dev. 2014 May 15; 28(10):1085-100. Yan K, Wu Q, Yan DH, Lee CH, Rahim N, Tritschler I, DeVecchio J, Kalady MF, Hjelmeland AB, Rich JN. PMID: 24788093.
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    115. Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1a accumulation. Nat Cell Biol. 2014 May; 16(5):445-56. Fan Y, Potdar AA, Gong Y, Eswarappa SM, Donnola S, Lathia JD, Hambardzumyan D, Rich JN, Fox PL. PMID: 24747440.
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    116. High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues. Nat Photonics. 2014; 8:627-634. Camp CH, Lee YJ, Heddleston JM, Hartshorn CM, Hight Walker AR, Rich JN, Lathia JD, Cicerone MT. PMID: 25621002.
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    117. High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. Cell Rep. 2014 Jan 16; 6(1):117-29. Lathia JD, Li M, Sinyuk M, Alvarado AG, Flavahan WA, Stoltz K, Rosager AM, Hale J, Hitomi M, Gallagher J, Wu Q, Martin J, Vidal JG, Nakano I, Dahlrot RH, Hansen S, McLendon RE, Sloan AE, Bao S, Hjelmeland AB, Carson CT, Naik UP, Kristensen B, Rich JN. PMID: 24373972.
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    118. miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):291-6. Mathew LK, Skuli N, Mucaj V, Lee SS, Zinn PO, Sathyan P, Imtiyaz HZ, Zhang Z, Davuluri RV, Rao S, Venneti S, Lal P, Lathia JD, Rich JN, Keith B, Minn AJ, Simon MC. PMID: 24368849.
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    119. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med. 2013 Dec 16; 210(13):2851-72. Lotti F, Jarrar AM, Pai RK, Hitomi M, Lathia J, Mace A, Gantt GA, Sukhdeo K, DeVecchio J, Vasanji A, Leahy P, Hjelmeland AB, Kalady MF, Rich JN. PMID: 24323355.
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    120. The evolving landscape of glioblastoma stem cells. Curr Opin Neurol. 2013 Dec; 26(6):701-7. Yan K, Yang K, Rich JN. PMID: 24152818.
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    121. Sleeve lobectomy for non-small cell lung cancer with N1 nodal disease does not compromise survival. Ann Thorac Surg. 2014 Jan; 97(1):230-5. Berry MF, Worni M, Wang X, Harpole DH, D'Amico TA, Onaitis MW. PMID: 24246263.
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    122. Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr Relat Cancer. 2013 Dec; 20(6):797-808. Zheng Q, Banaszak L, Fracci S, Basali D, Dunlap SM, Hursting SD, Rich JN, Hjlemeland AB, Vasanji A, Berger NA, Lathia JD, Reizes O. PMID: 24025407.
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    123. Genomics informs glioblastoma biology. Nat Genet. 2013 Oct; 45(10):1105-7. Schonberg DL, Bao S, Rich JN. PMID: 24071842.
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    124. Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci. 2013 Oct; 16(10):1373-82. Flavahan WA, Wu Q, Hitomi M, Rahim N, Kim Y, Sloan AE, Weil RJ, Nakano I, Sarkaria JN, Stringer BW, Day BW, Li M, Lathia JD, Rich JN, Hjelmeland AB. PMID: 23995067.
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    125. Changing the fate of cancer, one splice at a time. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14510-1. Schonberg DL, Venere M, Rich JN. PMID: 23969832.
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    126. Tumor cells upregulate normoxic HIF-1a in response to doxorubicin. Cancer Res. 2013 Oct 15; 73(20):6230-42. Cao Y, Eble JM, Moon E, Yuan H, Weitzel DH, Landon CD, Nien CY, Hanna G, Rich JN, Provenzale JM, Dewhirst MW. PMID: 23959856.
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    127. Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma. PLoS One. 2013; 8(8):e70962. Schulte JD, Srikanth M, Das S, Zhang J, Lathia JD, Yin L, Rich JN, Olson EC, Kessler JA, Chenn A. PMID: 23951053.
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    128. Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy. PLoS One. 2013; 8(8):e70804. Liu WM, Huang P, Kar N, Burgett M, Muller-Greven G, Nowacki AS, Distelhorst CW, Lathia JD, Rich JN, Kappes JC, Gladson CL. PMID: 23936469.
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    129. Brain tumor stem cells: Molecular characteristics and their impact on therapy. Mol Aspects Med. 2014 Oct; 39:82-101. Schonberg DL, Lubelski D, Miller TE, Rich JN. PMID: 23831316.
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    130. Decoding the cancer stem cell hypothesis in glioblastoma. CNS Oncol. 2013 Jul; 2(4):319-30. Hale JS, Sinyuk M, Rich JN, Lathia JD. PMID: 24379973.
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    131. Aptamer identification of brain tumor-initiating cells. Cancer Res. 2013 Aug 01; 73(15):4923-36. Kim Y, Wu Q, Hamerlik P, Hitomi M, Sloan AE, Barnett GH, Weil RJ, Leahy P, Hjelmeland AB, Rich JN. PMID: 23796560.
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    132. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell. 2013 Jun 10; 23(6):839-52. Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, Oh YT, Kim H, Rheey J, Nakano I, Lee C, Joo KM, Rich JN, Nam DH, Lee J. PMID: 23684459.
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    133. Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell. 2013 Mar 28; 153(1):139-52. Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, Min W, McLendon RE, Rich JN, Bao S. PMID: 23540695.
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    134. ß-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma. Cancer Res. 2013 May 15; 73(10):3181-9. Xu C, Xie D, Yu SC, Yang XJ, He LR, Yang J, Ping YF, Wang B, Yang L, Xu SL, Cui W, Wang QL, Fu WJ, Liu Q, Qian C, Cui YH, Rich JN, Kung HF, Zhang X, Bian XW. PMID: 23539445.
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    135. Growth factor receptors define cancer hierarchies. Cancer Cell. 2013 Feb 11; 23(2):135-7. Venere M, Lathia JD, Rich JN. PMID: 23410969.
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    136. Mitotic control of cancer stem cells. Cancer Discov. 2013 Feb; 3(2):141-4. Venere M, Miller TE, Rich JN. PMID: 23400473.
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    137. Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines. PLoS One. 2013; 8(1):e53015. Sukhdeo K, Paramban RI, Vidal JG, Elia J, Martin J, Rivera M, Carrasco DR, Jarrar A, Kalady MF, Carson CT, Balderas R, Hjelmeland AB, Lathia JD, Rich JN. PMID: 23308131.
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    138. Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol. 2012 Nov; 72(5):766-78. Lathia JD, Li M, Hall PE, Gallagher J, Hale JS, Wu Q, Venere M, Levy E, Rani MR, Huang P, Bae E, Selfridge J, Cheng L, Guvenc H, McLendon RE, Nakano I, Sloan AE, Phillips HS, Lai A, Gladson CL, Bredel M, Bao S, Hjelmeland AB, Rich JN. PMID: 23280793.
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    139. Looking in the miR-ror: TGF-ß-mediated activation of NF-?B in glioma. J Clin Invest. 2012 Oct; 122(10):3473-5. Eyler CE, Rich JN. PMID: 23006324.
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    140. TRP-ing up brain tumors. Nat Med. 2012 Aug; 18(8):1175-6. Schonberg DL, Bao S, Rich JN. PMID: 22869181.
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    141. Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair. Trends Neurosci. 2012 Oct; 35(10):619-28. Li M, Hale JS, Rich JN, Ransohoff RM, Lathia JD. PMID: 22784557.
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    142. The quest for self-identity: not all cancer stem cells are the same. Clin Cancer Res. 2012 Jul 01; 18(13):3495-8. Hjelmeland AB, Rich JN. PMID: 22711710.
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    143. All-cause mortality and obstructive sleep apnea severity revisited. Otolaryngol Head Neck Surg. 2012 Sep; 147(3):583-7. Rich J, Raviv A, Raviv N, Brietzke SE. PMID: 22687326.
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    144. Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev. 2012 Jun 01; 26(11):1247-62. Kim Y, Kim E, Wu Q, Guryanova O, Hitomi M, Lathia JD, Serwanski D, Sloan AE, Weil RJ, Lee J, Nishiyama A, Bao S, Hjelmeland AB, Rich JN. PMID: 22661233.
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    145. MET signaling regulates glioblastoma stem cells. Cancer Res. 2012 Aug 01; 72(15):3828-38. Joo KM, Jin J, Kim E, Ho Kim K, Kim Y, Gu Kang B, Kang YJ, Lathia JD, Cheong KH, Song PH, Kim H, Seol HJ, Kong DS, Lee JI, Rich JN, Lee J, Nam DH. PMID: 22617325.
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    146. Holding on to stemness. Nat Cell Biol. 2012 May 02; 14(5):450-2. Lathia JD, Rich JN. PMID: 22552145.
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    147. Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma. J Neurooncol. 2012 Jul; 108(3):499-506. Reardon DA, Vredenburgh JJ, Desjardins A, Peters KB, Sathornsumetee S, Threatt S, Sampson JH, Herndon JE, Coan A, McSherry F, Rich JN, McLendon RE, Zhang S, Friedman HS. PMID: 22407177.
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    148. Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin a6ß1 in glioblastoma. Cancer Res. 2012 Mar 15; 72(6):1428-37. Huang P, Rani MR, Ahluwalia MS, Bae E, Prayson RA, Weil RJ, Nowacki AS, Hedayat H, Sloan AE, Lathia JD, Rich JN, Tipps R, Gladson CL. PMID: 22396498.
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    149. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med. 2012 Mar 12; 209(3):507-20. Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, Lee M, Moudry P, Bartek J, Fischer W, Lukas J, Rich JN, Bartek J. PMID: 22393126.
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    150. Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma. Cancer. 2012 Oct 01; 118(19):4759-67. Reardon DA, Desjardins A, Vredenburgh JJ, Herndon JE, Coan A, Gururangan S, Peters KB, McLendon R, Sathornsumetee S, Rich JN, Lipp ES, Janney D, Friedman HS. PMID: 22371319.
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    151. Molecularly targeted therapy in neuro-oncology. Handb Clin Neurol. 2012; 104:255-78. Sathornsumetee S, Rich JN. PMID: 22230448.
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    152. Notch signaling in cancer stem cells. Adv Exp Med Biol. 2012; 727:174-85. Wang J, Sullenger BA, Rich JN. PMID: 22399347.
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    153. Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression. Curr Radiopharm. 2012 Jan; 5(1):47-58. Chin BB, Hjelemand A, Rich J, Song H, Lascola C, Storms R, McLendon R, Reiman R, Greer KL, Metzler SD, McDougald D, Dai D, Vaidyanathan G. PMID: 21864242.
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    154. Twisted tango: brain tumor neurovascular interactions. Nat Neurosci. 2011 Oct 26; 14(11):1375-81. Hjelmeland AB, Lathia JD, Sathornsumetee S, Rich JN. PMID: 22030548.
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    155. Outcome after bevacizumab clinical trial therapy among recurrent grade III malignant glioma patients. J Neurooncol. 2012 Mar; 107(1):213-21. Reardon DA, Herndon JE, Peters K, Desjardins A, Coan A, Lou E, Sumrall A, Turner S, Sathornsumetee S, Rich JN, Boulton S, Lipp ES, Friedman HS, Vredenburgh JJ. PMID: 21997879.
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    156. Pharmacokinetic drug interaction between AEE788 and RAD001 causing thrombocytopenia in patients with glioblastoma. Cancer Chemother Pharmacol. 2012 Jan; 69(1):281-7. Reardon DA, Cloughesy T, Rich J, Alfred Yung WK, Yung L, DiLea C, Huang J, Dugan M, Mietlowski W, Maes A, Conrad C. PMID: 21984222.
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    157. Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One. 2011; 6(9):e24807. Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, McLendon RE, Hjelmeland AB, Huang AY, Rich JN. PMID: 21961046.
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    158. Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfa production and reduced neutrophil clearance. PLoS One. 2011; 6(8):e23633. Hanses F, Park S, Rich J, Lee JC. PMID: 21912601.
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    159. An epidemiologic study of snoring and all-cause mortality. Otolaryngol Head Neck Surg. 2011 Aug; 145(2):341-6. Rich J, Raviv A, Raviv N, Brietzke SE. PMID: 21493281.
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    160. Glioma development: where did it all go wrong? Cell. 2011 Jul 22; 146(2):187-8. Sukhdeo K, Hambardzumyan D, Rich JN. PMID: 21784240.
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    161. Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. Endocr Relat Cancer. 2011 Aug; 18(4):491-503. Zheng Q, Dunlap SM, Zhu J, Downs-Kelly E, Rich J, Hursting SD, Berger NA, Reizes O. PMID: 21636700.
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    162. Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma. J Neurooncol. 2011 Dec; 105(3):621-7. Reardon DA, Vredenburgh JJ, Coan A, Desjardins A, Peters KB, Gururangan S, Sathornsumetee S, Rich JN, Herndon JE, Friedman HS. PMID: 21744079.
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    163. Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell. 2011 Jul 08; 146(1):53-66. Eyler CE, Wu Q, Yan K, MacSwords JM, Chandler-Militello D, Misuraca KL, Lathia JD, Forrester MT, Lee J, Stamler JS, Goldman SA, Bredel M, McLendon RE, Sloan AE, Hjelmeland AB, Rich JN. PMID: 21729780.
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    164. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 2011 Jul 01; 71(13):4640-52. Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM, Pinna CM, Hubaud A, Stadler B, Choi M, Bar M, Tewari M, Liu A, Vessella R, Rostomily R, Born D, Horwitz M, Ware C, Blau CA, Cleary MA, Rich JN, Ruohola-Baker H. PMID: 21712410.
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    165. Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology? Stem Cell Rev Rep. 2011 Jun; 7(2):227-37. Lathia JD, Venere M, Rao MS, Rich JN. PMID: 20957452.
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    166. Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell. 2011 May 06; 8(5):482-5. Lathia JD, Heddleston JM, Venere M, Rich JN. PMID: 21549324.
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    167. Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia. 2011 Aug; 59(8):1148-54. Venere M, Fine HA, Dirks PB, Rich JN. PMID: 21547954.
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    168. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell. 2011 Apr 12; 19(4):498-511. Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, MacSwords J, Eyler CE, McLendon RE, Heddleston JM, Shou W, Hambardzumyan D, Lee J, Hjelmeland AB, Sloan AE, Bredel M, Stark GR, Rich JN, Bao S. PMID: 21481791.
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    169. Elevated invasive potential of glioblastoma stem cells. Biochem Biophys Res Commun. 2011 Mar 25; 406(4):643-8. Cheng L, Wu Q, Guryanova OA, Huang Z, Huang Q, Rich JN, Bao S. PMID: 21371437.
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    170. L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J. 2011 Mar 02; 30(5):800-13. Cheng L, Wu Q, Huang Z, Guryanova OA, Huang Q, Shou W, Rich JN, Bao S. PMID: 21297581.
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    171. Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol. 2011 Feb; 13(2):142-52. Huang Z, Wu Q, Guryanova OA, Cheng L, Shou W, Rich JN, Bao S. PMID: 21258371.
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    172. Molecular targeting of neural cancer stem cells: TTAGGG, you're it! Clin Cancer Res. 2011 Jan 01; 17(1):3-5. Hjelmeland AB, Rich JN. PMID: 21208901.
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    173. Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology. Biotechniques. 2011 Jan; 50(1):41-5. Forrester MT, Eyler CE, Rich JN. PMID: 21231921.
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    174. Glioma stem cell maintenance: the role of the microenvironment. Curr Pharm Des. 2011; 17(23):2386-401. Heddleston JM, Hitomi M, Venere M, Flavahan WA, Yang K, Kim Y, Minhas S, Rich JN, Hjelmeland AB. PMID: 21827414.
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    175. Using a stem cell-based signature to guide therapeutic selection in cancer. Cancer Res. 2011 Mar 01; 71(5):1772-80. Shats I, Gatza ML, Chang JT, Mori S, Wang J, Rich J, Nevins JR. PMID: 21169407.
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    176. Glioblastoma Stem Cells: A Neuropathologist's View. J Oncol. 2011; 2011:397195. McLendon RE, Rich JN. PMID: 21052560.
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    178. Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol. 2011 Jun; 103(2):371-9. Reardon DA, Desjardins A, Peters K, Gururangan S, Sampson J, Rich JN, McLendon R, Herndon JE, Marcello J, Threatt S, Friedman AH, Vredenburgh JJ, Friedman HS. PMID: 20853132.
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    179. Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol. 2010 Dec; 12(12):1300-10. Sathornsumetee S, Desjardins A, Vredenburgh JJ, McLendon RE, Marcello J, Herndon JE, Mathe A, Hamilton M, Rich JN, Norfleet JA, Gururangan S, Friedman HS, Reardon DA. PMID: 20716591.
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    180. Dynamic and transient cancer stem cells nurture melanoma. Nat Med. 2010 Jul; 16(7):758. Weinberg R, Fisher DE, Rich J. PMID: 20613753.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    181. Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol. 2010 Sep 01; 80(5):654-65. Cheng L, Bao S, Rich JN. PMID: 20457135.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    182. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell. 2010 May 07; 6(5):421-32. Lathia JD, Gallagher J, Heddleston JM, Wang J, Eyler CE, Macswords J, Wu Q, Vasanji A, McLendon RE, Hjelmeland AB, Rich JN. PMID: 20452317.
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    183. Informed consent in pediatric surgery: Do parents understand the risks? Arch Otolaryngol Head Neck Surg. 2010 Mar; 136(3):265-9. Nadeau DP, Rich JN, Brietzke SE. PMID: 20231645.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    184. Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol. 2010 Feb 23; 8(2):e1000319. Hjelmeland AB, Wu Q, Wickman S, Eyler C, Heddleston J, Shi Q, Lathia JD, Macswords J, Lee J, McLendon RE, Rich JN. PMID: 20186265.
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    185. Medical oncology: treatment and management of malignant gliomas. Nat Rev Clin Oncol. 2010 Feb; 7(2):75-7. Park DM, Sathornsumetee S, Rich JN. PMID: 20118976.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    186. Notch promotes radioresistance of glioma stem cells. Stem Cells. 2010 Jan; 28(1):17-28. Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, Rich JN, Sullenger BA. PMID: 19921751.
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    187. Hypoxia and hypoxia inducible factors in cancer stem cell maintenance. Curr Top Microbiol Immunol. 2010; 345:21-30. Li Z, Rich JN. PMID: 20582533.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    188. Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance. Genes Cancer. 2010 Jan 01; 1(1):50-61. Cao Y, Lathia JD, Eyler CE, Wu Q, Li Z, Wang H, McLendon RE, Hjelmeland AB, Rich JN. PMID: 20657792.
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    189. Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res. 2010 Jan 01; 70(1):418-27. Chigurupati S, Venkataraman R, Barrera D, Naganathan A, Madan M, Paul L, Pattisapu JV, Kyriazis GA, Sugaya K, Bushnev S, Lathia JD, Rich JN, Chan SL. PMID: 20028870.
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    190. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. . 2009 Oct 15; 8(20):3274-84. Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN. PMID: 19770585.
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    191. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells. 2009 Oct; 27(10):2393-404. Wang H, Lathia JD, Wu Q, Wang J, Li Z, Heddleston JM, Eyler CE, Elderbroom J, Gallagher J, Schuschu J, MacSwords J, Cao Y, McLendon RE, Wang XF, Hjelmeland AB, Rich JN. PMID: 19658188.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    192. Squelching glioblastoma stem cells by targeting REST for proteasomal degradation. Trends Neurosci. 2009 Nov; 32(11):559-65. Zhang P, Lathia JD, Flavahan WA, Rich JN, Mattson MP. PMID: 19748686.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    193. Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy. Cancer. 2009 Aug 01; 115(15):3501-11. Affronti ML, Heery CR, Herndon JE, Rich JN, Reardon DA, Desjardins A, Vredenburgh JJ, Friedman AH, Bigner DD, Friedman HS. PMID: 19514083.
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    194. Biology of glioma cancer stem cells. Mol Cells. 2009 Jul 31; 28(1):7-12. Park DM, Rich JN. PMID: 19655094.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    195. NDRG4 is required for cell cycle progression and survival in glioblastoma cells. J Biol Chem. 2009 Sep 11; 284(37):25160-9. Schilling SH, Hjelmeland AB, Radiloff DR, Liu IM, Wakeman TP, Fielhauer JR, Foster EH, Lathia JD, Rich JN, Wang XF, Datto MB. PMID: 19592488.
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    196. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell. 2009 Jun 02; 15(6):501-13. Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, Hjelmeland AB, Rich JN. PMID: 19477429.
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    197. Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma. Neuro Oncol. 2009 Oct; 11(5):556-61. Quinn JA, Jiang SX, Reardon DA, Desjardins A, Vredenburgh JJ, Rich JN, Gururangan S, Friedman AH, Bigner DD, Sampson JH, McLendon RE, Herndon JE, Walker A, Friedman HS. PMID: 19289491.
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    198. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem. 2009 Jun 19; 284(25):16705-16709. Li Z, Wang H, Eyler CE, Hjelmeland AB, Rich JN. PMID: 19286664.
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    199. Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10; 27(8):1262-7. Quinn JA, Jiang SX, Reardon DA, Desjardins A, Vredenburgh JJ, Rich JN, Gururangan S, Friedman AH, Bigner DD, Sampson JH, McLendon RE, Herndon JE, Walker A, Friedman HS. PMID: 19204199.
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    200. Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. Clin Cancer Res. 2009 Feb 01; 15(3):1064-8. Quinn JA, Jiang SX, Carter J, Reardon DA, Desjardins A, Vredenburgh JJ, Rich JN, Gururangan S, Friedman AH, Bigner DD, Sampson JH, McLendon RE, Herndon JE, Threatt S, Friedman HS. PMID: 19188181.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    201. Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus. Infect Immun. 2009 Mar; 77(3):1008-14. Park S, Rich J, Hanses F, Lee JC. PMID: 19103772.
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    202. c-Myc is required for maintenance of glioma cancer stem cells. PLoS One. 2008; 3(11):e3769. Wang J, Wang H, Li Z, Wu Q, Lathia JD, McLendon RE, Hjelmeland AB, Rich JN. PMID: 19020659.
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    203. Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. Clin Cancer Res. 2008 Nov 01; 14(21):7068-73. Desjardins A, Reardon DA, Herndon JE, Marcello J, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Bailey L, Bigner DD, Friedman AH, Friedman HS, Vredenburgh JJ. PMID: 18981004.
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    204. Designer therapies for glioblastoma multiforme. Ann N Y Acad Sci. 2008 Oct; 1142:108-32. Sathornsumetee S, Rich JN. PMID: 18990124.
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    205. Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells. 2008 Dec; 26(12):3027-36. Eyler CE, Foo WC, LaFiura KM, McLendon RE, Hjelmeland AB, Rich JN. PMID: 18802038.
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    206. Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol. 2008 Oct; 10(5):745-51. Gururangan S, Krauser J, Watral MA, Driscoll T, Larrier N, Reardon DA, Rich JN, Quinn JA, Vredenburgh JJ, Desjardins A, McLendon RE, Fuchs H, Kurtzberg J, Friedman HS. PMID: 18755919.
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    207. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 2008 Aug 01; 68(15):6043-8. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, Hjelmeland AB, Rich JN. PMID: 18676824.
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    208. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol. 2008 Jun 10; 26(17):2839-45. Eyler CE, Rich JN. PMID: 18539962.
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    209. The Implications of the Cancer Stem Cell Hypothesis for Neuro-Oncology and Neurology. Future Neurol. 2008 May 01; 3(3):265-273. Rich JN. PMID: 19763280.
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    210. Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma. Neuro Oncol. 2008 Jun; 10(3):330-40. Reardon DA, Desjardins A, Vredenburgh JJ, Sathornsumetee S, Rich JN, Quinn JA, Lagattuta TF, Egorin MJ, Gururangan S, McLendon R, Herndon JE, Friedman AH, Salvado AJ, Friedman HS. PMID: 18359865.
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    211. A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost. Neuro Oncol. 2008 Apr; 10(2):182-9. Reardon DA, Zalutsky MR, Akabani G, Coleman RE, Friedman AH, Herndon JE, McLendon RE, Pegram CN, Quinn JA, Rich JN, Vredenburgh JJ, Desjardins A, Guruangan S, Boulton S, Raynor RH, Dowell JM, Wong TZ, Zhao XG, Friedman HS, Bigner DD. PMID: 18287339.
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    212. The emerging role of anti-angiogenic therapy for malignant glioma. Curr Treat Options Oncol. 2008 Feb; 9(1):1-22. Reardon DA, Desjardins A, Rich JN, Vredenburgh JJ. PMID: 18256938.
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    213. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol. 2008 Jan 10; 26(2):271-8. Sathornsumetee S, Cao Y, Marcello JE, Herndon JE, McLendon RE, Desjardins A, Friedman HS, Dewhirst MW, Vredenburgh JJ, Rich JN. PMID: 18182667.
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    214. Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007 Nov; 25(4):1111-39, x. Sathornsumetee S, Rich JN, Reardon DA. PMID: 17964028.
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    215. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol. 2007 Oct 20; 25(30):4722-9. Vredenburgh JJ, Desjardins A, Herndon JE, Marcello J, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L, Bigner DD, Friedman AH, Friedman HS. PMID: 17947719.
      View in: PubMed   Mentions: 530     Fields:    Translation:HumansCTClinical Trials
    216. Chemotherapy and cancer stem cells. Cell Stem Cell. 2007 Oct 11; 1(4):353-5. Rich JN, Bao S. PMID: 18371369.
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    217. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer. 2007 10; 7(10):733-6. Gilbertson RJ, Rich JN. PMID: 17882276.
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    218. Cancer stem cells in radiation resistance. Cancer Res. 2007 Oct 01; 67(19):8980-4. Rich JN. PMID: 17908997.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    219. Second messenger systems in human gliomas. Arch Pathol Lab Med. 2007 Oct; 131(10):1585-90. McLendon RE, Turner K, Perkinson K, Rich J. PMID: 17922598.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    220. The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. . 2007 Sep; 6(9):2449-57. Hjelmeland AB, Lattimore KP, Fee BE, Shi Q, Wickman S, Keir ST, Hjelmeland MD, Batt D, Bigner DD, Friedman HS, Rich JN. PMID: 17766837.
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    221. Molecularly targeted therapy for malignant glioma. Cancer. 2007 Jul 01; 110(1):13-24. Sathornsumetee S, Reardon DA, Desjardins A, Quinn JA, Vredenburgh JJ, Rich JN. PMID: 17520692.
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    222. A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog. 2007 Jun; 46(6):488-96. Shi Q, Hjelmeland AB, Keir ST, Song L, Wickman S, Jackson D, Ohmori O, Bigner DD, Friedman HS, Rich JN. PMID: 17219439.
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    223. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res. 2007 Feb 15; 13(4):1253-9. Vredenburgh JJ, Desjardins A, Herndon JE, Dowell JM, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH, Friedman HS. PMID: 17317837.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansCTClinical Trials
    224. Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. J Neurooncol. 2007 May; 83(1):53-60. Desjardins A, Quinn JA, Vredenburgh JJ, Sathornsumetee S, Friedman AH, Herndon JE, McLendon RE, Provenzale JM, Rich JN, Sampson JH, Gururangan S, Dowell JM, Salvado A, Friedman HS, Reardon DA. PMID: 17245623.
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    225. Antiangiogenic therapy in malignant glioma: promise and challenge. Curr Pharm Des. 2007; 13(35):3545-58. Sathornsumetee S, Rich JN. PMID: 18220791.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    226. Malignant glioma drug discovery - targeting protein kinases. Expert Opin Drug Discov. 2007 Jan; 2(1):1-17. Sathornsumetee S, Vredenburgh KA, Lattimore KP, Rich JN. PMID: 23496034.
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    227. Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme. Neuro Oncol. 2007 Jan; 9(1):70-4. Badruddoja MA, Penne K, Desjardins A, Reardon DA, Rich JN, Quinn JA, Sathornsumetee S, Friedman AH, Bigner DD, Herndon JE, Cahill A, Friedman HS, Vredenburgh JJ. PMID: 17108065.
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    228. The cancer stem cell: a new therapeutic paradigm? Expert Rev Anticancer Ther. 2006 Nov; 6(11):1531-3. Rich JN. PMID: 17134357.
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    229. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006 Dec 07; 444(7120):756-60. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. PMID: 17051156.
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    230. New approaches to primary brain tumor treatment. Anticancer Drugs. 2006 Oct; 17(9):1003-16. Sathornsumetee S, Rich JN. PMID: 17001172.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    231. Vandetanib, a novel multitargeted kinase inhibitor, in cancer therapy. Drugs Today (Barc). 2006 Oct; 42(10):657-70. Sathornsumetee S, Rich JN. PMID: 17136225.
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    232. APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2. Circ Res. 2006 Oct 13; 99(8):829-36. DeKroon R, Robinette JB, Hjelmeland AB, Wiggins E, Blackwell M, Mihovilovic M, Fujii M, York J, Hart J, Kontos C, Rich J, Strittmatter WJ. PMID: 16973905.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    233. AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma. Cancer Res. 2006 Sep 01; 66(17):8722-30. Sathornsumetee S, Hjelmeland AB, Keir ST, McLendon RE, Batt D, Ramsey T, Yusuff N, Rasheed BK, Kieran MW, Laforme A, Bigner DD, Friedman HS, Rich JN. PMID: 16951188.
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    234. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006 Aug 15; 66(16):7843-8. Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, Shi Q, McLendon RE, Bigner DD, Rich JN. PMID: 16912155.
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    235. New treatment strategies for malignant gliomas. Expert Rev Anticancer Ther. 2006 Jul; 6(7):1087-104. Sathornsumetee S, Rich JN. PMID: 16831080.
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    236. CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10408-10413. McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC. PMID: 16801559.
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    237. Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results. J Nucl Med. 2006 Jun; 47(6):912-8. Reardon DA, Quinn JA, Akabani G, Coleman RE, Friedman AH, Friedman HS, Herndon JE, McLendon RE, Pegram CN, Provenzale JM, Dowell JM, Rich JN, Vredenburgh JJ, Desjardins A, Sampson JH, Gururangan S, Wong TZ, Badruddoja MA, Zhao XG, Bigner DD, Zalutsky MR. PMID: 16741299.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic HealthCTClinical Trials
    238. Recent advances in the treatment of malignant astrocytoma. J Clin Oncol. 2006 Mar 10; 24(8):1253-65. Reardon DA, Rich JN, Friedman HS, Bigner DD. PMID: 16525180.
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    239. Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res. 2006 Feb 01; 12(3 Pt 1):860-8. Reardon DA, Quinn JA, Vredenburgh JJ, Gururangan S, Friedman AH, Desjardins A, Sathornsumetee S, Herndon JE, Dowell JM, McLendon RE, Provenzale JM, Sampson JH, Smith RP, Swaisland AJ, Ochs JS, Lyons P, Tourt-Uhlig S, Bigner DD, Friedman HS, Rich JN. PMID: 16467100.
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    240. Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results. J Clin Oncol. 2006 Jan 01; 24(1):115-22. Reardon DA, Akabani G, Coleman RE, Friedman AH, Friedman HS, Herndon JE, McLendon RE, Pegram CN, Provenzale JM, Quinn JA, Rich JN, Vredenburgh JJ, Desjardins A, Gururangan S, Guruangan S, Badruddoja M, Dowell JM, Wong TZ, Zhao XG, Zalutsky MR, Bigner DD. PMID: 16382120.
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    241. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol. 2005 Dec 20; 23(36):9359-68. Reardon DA, Egorin MJ, Quinn JA, Rich JN, Rich JN, Gururangan S, Gururangan I, Vredenburgh JJ, Desjardins A, Sathornsumetee S, Provenzale JM, Herndon JE, Dowell JM, Badruddoja MA, McLendon RE, Lagattuta TF, Kicielinski KP, Dresemann G, Sampson JH, Friedman AH, Salvado AJ, Friedman HS. PMID: 16361636.
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    242. Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. Cancer Res. 2005 Dec 15; 65(24):11276-81. Hjelmeland AB, Hjelmeland MD, Shi Q, Hart JL, Bigner DD, Wang XF, Kontos CD, Rich JN. PMID: 16357132.
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    243. ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin Cancer Res. 2005 Nov 15; 11(22):8145-57. Rich JN, Sathornsumetee S, Keir ST, Kieran MW, Laforme A, Kaipainen A, McLendon RE, Graner MW, Rasheed BK, Wang L, Reardon DA, Ryan AJ, Wheeler C, Dimery I, Bigner DD, Friedman HS. PMID: 16299247.
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    244. Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2005 Oct 01; 23(28):7178-87. Quinn JA, Desjardins A, Weingart J, Brem H, Dolan ME, Delaney SM, Vredenburgh J, Rich J, Friedman AH, Reardon DA, Sampson JH, Pegg AE, Moschel RC, Birch R, McLendon RE, Provenzale JM, Gururangan S, Dancey JE, Maxwell J, Tourt-Uhlig S, Herndon JE, Bigner DD, Friedman HS. PMID: 16192602.
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    245. Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma. Cancer. 2005 Oct 01; 104(7):1478-86. Reardon DA, Quinn JA, Rich JN, Desjardins A, Vredenburgh J, Gururangan S, Sathornsumetee S, Badruddoja M, McLendon R, Provenzale J, Herndon JE, Dowell JM, Burkart JL, Newton HB, Friedman AH, Friedman HS. PMID: 16088964.
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    246. The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse. Diabetes. 2005 Oct; 54(10):2904-10. Rich J, Lee JC. PMID: 16186391.
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    247. Chemotherapy and novel therapeutic approaches in malignant glioma. Front Biosci. 2005 Sep 01; 10:2645-68. Desjardins A, Rich JN, Quinn JA, Vredenburgh J, Gururangan S, Sathornsumetee S, Reardon DA, Friedman AH, Bigner DD, Friedman HS. PMID: 15970525.
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    248. Gene expression profiling and genetic markers in glioblastoma survival. Cancer Res. 2005 May 15; 65(10):4051-8. Rich JN, Hans C, Jones B, Iversen ES, McLendon RE, Rasheed BK, Dobra A, Dressman HK, Bigner DD, Nevins JR, West M. PMID: 15899794.
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    249. Human identification from the ankle with pre- and postsurgical radiographs. J Clin Forensic Med. 2005 Feb; 12(1):5-9. Dean DE, Tatarek NE, Rich J, Brogdon BG, Powers RH. PMID: 15763682.
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    250. Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. Cancer. 2005 Jan 15; 103(2):329-38. Reardon DA, Quinn JA, Vredenburgh J, Rich JN, Gururangan S, Badruddoja M, Herndon JE, Dowell JM, Friedman AH, Friedman HS. PMID: 15558802.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    251. Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. . 2005 Jan; 4(1):101-12. Goudar RK, Shi Q, Hjelmeland MD, Keir ST, McLendon RE, Wikstrand CJ, Reese ED, Conrad CA, Traxler P, Lane HA, Reardon DA, Cavenee WK, Wang XF, Bigner DD, Friedman HS, Rich JN. PMID: 15657358.
      View in: PubMed   Mentions:
    252. Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation. J Biol Chem. 2004 Dec 10; 279(50):52200-9. Shi Q, Bao S, Maxwell JA, Reese ED, Friedman HS, Bigner DD, Wang XF, Rich JN. PMID: 15469933.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    253. EGFR mutations and sensitivity to gefitinib. N Engl J Med. 2004 Sep 16; 351(12):1260-1; author reply 1260-1. Rich JN, Rasheed BK, Yan H. PMID: 15376352.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    254. SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. . 2004 Jun; 3(6):737-45. Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, Reese ED, Herbstreith MH, Laping NJ, Friedman HS, Bigner DD, Wang XF, Rich JN. PMID: 15210860.
      View in: PubMed   Mentions:
    255. Development of novel targeted therapies in the treatment of malignant glioma. Nat Rev Drug Discov. 2004 May; 3(5):430-46. Rich JN, Bigner DD. PMID: 15136790.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    256. Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. Clin Cancer Res. 2004 May 01; 10(9):3216-24. Learn CA, Hartzell TL, Wikstrand CJ, Archer GE, Rich JN, Friedman AH, Friedman HS, Bigner DD, Sampson JH. PMID: 15131063.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    257. Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma. Neuro Oncol. 2004 Apr; 6(2):145-53. Quinn JA, Reardon DA, Friedman AH, Rich JN, Sampson JH, Vredenburgh J, Gururangan S, Provenzale JM, Walker A, Schweitzer H, Bigner DD, Tourt-Uhlig S, Herndon JE, Affronti ML, Jackson S, Allen D, Ziegler K, Bohlin C, Lentz C, Friedman HS. PMID: 15134629.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    258. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004 Apr; 5(4):329-39. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF. PMID: 15093540.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    259. Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma. Neuro Oncol. 2004 Apr; 6(2):134-44. Reardon DA, Quinn JA, Rich JN, Gururangan S, Vredenburgh J, Sampson JH, Provenzale JM, Walker A, Badruddoja M, Tourt-Uhlig S, Herndon JE, Dowell JM, Affronti ML, Jackson S, Allen D, Ziegler K, Silverman S, Bohlin C, Friedman AH, Bigner DD, Friedman HS. PMID: 15134628.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    260. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol. 2004 Jan 01; 22(1):133-42. Rich JN, Reardon DA, Peery T, Dowell JM, Quinn JA, Penne KL, Wikstrand CJ, Van Duyn LB, Dancey JE, McLendon RE, Kao JC, Stenzel TT, Ahmed Rasheed BK, Tourt-Uhlig SE, Herndon JE, Vredenburgh JJ, Sampson JH, Friedman AH, Bigner DD, Friedman HS. PMID: 14638850.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansCTClinical Trials
    261. Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. J Neurooncol. 2003 Oct; 65(1):27-35. Sampson JH, Akabani G, Archer GE, Bigner DD, Berger MS, Friedman AH, Friedman HS, Herndon JE, Kunwar S, Marcus S, McLendon RE, Paolino A, Penne K, Provenzale J, Quinn J, Reardon DA, Rich J, Stenzel T, Tourt-Uhlig S, Wikstrand C, Wong T, Williams R, Yuan F, Zalutsky MR, Pastan I. PMID: 14649883.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCellsCTClinical Trials
    262. Forensic implications of the foot and ankle. J Foot Ankle Surg. 2003 Jul-Aug; 42(4):221-5. Rich J, Dean DE, Cheung YY. PMID: 12907933.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    263. High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas. J Clin Oncol. 2003 Jun 01; 21(11):2187-91. Gururangan S, McLaughlin C, Quinn J, Rich J, Reardon D, Halperin EC, Herndon J, Fuchs H, George T, Provenzale J, Watral M, McLendon RE, Friedman A, Friedman HS, Kurtzberg J, Vredenbergh J, Martin PL. PMID: 12775745.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    264. Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem. 2003 May 02; 278(18):15951-7. Rich JN, Shi Q, Hjelmeland M, Cummings TJ, Kuan CT, Bigner DD, Counter CM, Wang XF. PMID: 12590137.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    265. Phase II trial of temozolomide in patients with progressive low-grade glioma. J Clin Oncol. 2003 Feb 15; 21(4):646-51. Quinn JA, Reardon DA, Friedman AH, Rich JN, Sampson JH, Provenzale JM, McLendon RE, Gururangan S, Bigner DD, Herndon JE, Avgeropoulos N, Finlay J, Tourt-Uhlig S, Affronti ML, Evans B, Stafford-Fox V, Zaknoen S, Friedman HS. PMID: 12586801.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCTClinical Trials
    266. The role of transforming growth factor-beta in primary brain tumors. Front Biosci. 2003 Jan 01; 8:e245-60. Rich JN. PMID: 12456378.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    267. Using pre- and post-surgical foot and ankle radiographs for identification. J Forensic Sci. 2002 Nov; 47(6):1319-22. Rich J, Tatarek NE, Powers RH, Brogdon BG, Lewis BJ, Dean DE. PMID: 12455656.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    268. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 2002 Aug 15; 16(16):2045-57. Hamad NM, Elconin JH, Karnoub AE, Bai W, Rich JN, Abraham RT, Der CJ, Counter CM. PMID: 12183360.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    269. Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol. 2002 May 01; 20(9):2277-83. Quinn JA, Pluda J, Dolan ME, Delaney S, Kaplan R, Rich JN, Friedman AH, Reardon DA, Sampson JH, Colvin OM, Haglund MM, Pegg AE, Moschel RC, McLendon RE, Provenzale JM, Gururangan S, Tourt-Uhlig S, Herndon JE, Bigner DD, Friedman HS. PMID: 11980998.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCTClinical Trials
    270. Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. J Clin Oncol. 2002 Mar 01; 20(5):1389-97. Reardon DA, Akabani G, Coleman RE, Friedman AH, Friedman HS, Herndon JE, Cokgor I, McLendon RE, Pegram CN, Provenzale JM, Quinn JA, Rich JN, Regalado LV, Sampson JH, Shafman TD, Wikstrand CJ, Wong TZ, Zhao XG, Zalutsky MR, Bigner DD. PMID: 11870184.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCTClinical Trials
    271. Using living skin equivalents for diabetic foot ulceration. Int J Low Extrem Wounds. 2002 Mar; 1(1):27-32. Pham HT, Rich J, Veves A. PMID: 15871949.
      View in: PubMed   Mentions: 3     Fields:    
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