Jeffrey Neul

TitleAdjunct Professor
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0626
La Jolla CA 92093
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    Collapse Research 
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    Neurobehavioral and biochemical outcome measures in Rett syndrome rodent models
    NIH/NICHD R01HD083181Sep 1, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt University
    NIH/NICHD U54HD083211Sep 17, 2015 - May 31, 2020
    Role: Principal Investigator
    The nature of astrocyte heterogeneity in RTT
    NIH/NINDS R21NS089366Feb 1, 2015 - Jan 31, 2017
    Role: Co-Principal Investigator
    Baylor Intellectual and Developmental Disabilities Research Centers
    NIH/NICHD U54HD083092Sep 23, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Characterization of autonomic dysfunction in Rett syndrome &other MECP2 disorder
    NIH/NICHD R01HD062553Jul 1, 2010 - May 31, 2015
    Role: Principal Investigator
    Analysis of the dopamine system in Rett syndrome
    NIH/NINDS K08NS052240Jul 1, 2005 - Sep 30, 2010
    Role: Principal Investigator

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    Collapse Clinical Trials

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Percy AK, Lane J, Annese F, Warren H, Skinner SA, Neul J. When Rett syndrome is due to genes other than MECP2. Transl Sci Rare Dis. 2018 Apr 13; 3(1):49-53. PMID: 29682453.
      View in: PubMed
    2. Tarquinio DC, Hou W, Neul J, Berkmen GK, Drummond J, Aronoff E, Harris J, Lane JB, Kaufmann WE, Motil KJ, Glaze DG, Skinner SA, Percy AK. The course of awake breathing disturbances across the lifespan in Rett syndrome. Brain Dev. 2018 Apr 12. PMID: 29657083.
      View in: PubMed
    3. Thurm A, Powell EM, Neul J, Wagner A, Zwaigenbaum L. Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms. Autism Res. 2018 Feb; 11(2):212-222. PMID: 29226600.
      View in: PubMed
    4. Sun JJ, Huang TW, Neul J, Ray RS. Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult. Sci Rep. 2017 Aug 22; 7(1):9117. PMID: 28831138.
      View in: PubMed
    5. Glaze DG, Neul J, Percy A, Feyma T, Beisang A, Yaroshinsky A, Stoms G, Zuchero D, Horrigan J, Glass L, Jones NE. A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Rett Syndrome. Pediatr Neurol. 2017 Nov; 76:37-46. PMID: 28964591.
      View in: PubMed
    6. Lane JB, Salter AR, Jones NE, Cutter G, Horrigan J, Skinner SA, Kaufmann WE, Glaze DG, Neul J, Percy AK. Assessment of Caregiver Inventory for Rett Syndrome. J Autism Dev Disord. 2017 04; 47(4):1102-1112. PMID: 28132121.
      View in: PubMed
    7. Killian JT, Lane JB, Lee HS, Skinner SA, Kaufmann WE, Glaze DG, Neul J, Percy AK. Scoliosis in Rett Syndrome: Progression, Comorbidities, and Predictors. Pediatr Neurol. 2017 May; 70:20-25. PMID: 28347601.
      View in: PubMed
    8. Tarquinio DC, Hou W, Berg A, Kaufmann WE, Lane JB, Skinner SA, Motil KJ, Neul J, Percy AK, Glaze DG. Longitudinal course of epilepsy in Rett syndrome and related disorders. Brain. 2017 02; 140(2):306-318. PMID: 28007990.
      View in: PubMed
    9. Herrera JA, Ward CS, Wehrens XH, Neul J. Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis. Hum Mol Genet. 2016 11 15; 25(22):4983-4995. PMID: 28159985.
      View in: PubMed
    10. Ward CS, Huang TW, Herrera JA, Samaco RC, Pitcher MR, Herron A, Skinner SA, Kaufmann WE, Glaze DG, Percy AK, Neul J. Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome. PLoS One. 2016; 11(11):e0165550. PMID: 27828991.
      View in: PubMed
    11. Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul J, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Hum Mol Genet. 2016 08 01; 25(15):3284-3302. PMID: 27365498.
      View in: PubMed
    12. Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul J, Pereira FA, Tang J, Xue M, Zoghbi HY. Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. Elife. 2016 06 21; 5. PMID: 27328325; PMCID: PMC4946906.
    13. Huang TW, Kochukov MY, Ward CS, Merritt J, Thomas K, Nguyen T, Arenkiel BR, Neul J. Progressive Changes in a Distributed Neural Circuit Underlie Breathing Abnormalities in Mice Lacking MeCP2. J Neurosci. 2016 05 18; 36(20):5572-86. PMID: 27194336; PMCID: PMC4871990 [Available on 11/18/16].
    14. Sajan SA, Jhangiani SN, Muzny DM, Gibbs RA, Lupski JR, Glaze DG, Kaufmann WE, Skinner SA, Annese F, Friez MJ, Lane J, Percy AK, Neul J. Enrichment of mutations in chromatin regulators in people with Rett syndrome lacking mutations in MECP2. Genet Med. 2017 01; 19(1):13-19. PMID: 27171548.
      View in: PubMed
    15. Killian JT, Lane JB, Lee HS, Pelham JH, Skinner SA, Kaufmann WE, Glaze DG, Neul J, Percy AK. Caretaker Quality of Life in Rett Syndrome: Disorder Features and Psychological Predictors. Pediatr Neurol. 2016 05; 58:67-74. PMID: 26995066.
      View in: PubMed
    16. Yuengert R, Hori K, Kibodeaux EE, McClellan JX, Morales JE, Huang TP, Neul J, Lai HC. Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function. Cell Rep. 2015 Nov 10; 13(6):1258-1271. PMID: 26527010; PMCID: PMC4644487.
    17. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul J, Bedalov A, Pieper AA. Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 Sep 24; 525(7570):552. PMID: 26176914.
      View in: PubMed
    18. Neul J, Sahin M. Therapeutic Advances in Autism and Other Neurodevelopmental Disorders. Neurotherapeutics. 2015 Jul; 12(3):519-20. PMID: 26076992; PMCID: PMC4489958.
    19. Tarquinio DC, Hou W, Neul J, Kaufmann WE, Glaze DG, Motil KJ, Skinner SA, Lee HS, Percy AK. The Changing Face of Survival in Rett Syndrome and MECP2-Related Disorders. Pediatr Neurol. 2015 Nov; 53(5):402-11. PMID: 26278631; PMCID: PMC4609589 [Available on 11/01/16].
    20. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vingeau S, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul J, Bedalov A, Pieper AA. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 May 21; 521(7552):E1-4. PMID: 25993969.
      View in: PubMed
    21. Neul J, Glaze DG, Percy AK, Feyma T, Beisang A, Dinh T, Suter B, Anagnostou E, Snape M, Horrigan J, Jones NE. Improving Treatment Trial Outcomes for Rett Syndrome: The Development of Rett-specific Anchors for the Clinical Global Impression Scale. J Child Neurol. 2015 Nov; 30(13):1743-8. PMID: 25895911; PMCID: PMC4610825.
    22. Herrera JA, Ward CS, Pitcher MR, Percy AK, Skinner S, Kaufmann WE, Glaze DG, Wehrens XH, Neul J. Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. Dis Model Mech. 2015 Apr; 8(4):363-71. PMID: 25713300; PMCID: PMC4381335.
    23. Tarquinio DC, Hou W, Neul J, Lane JB, Barnes KV, O'Leary HM, Bruck NM, Kaufmann WE, Motil KJ, Glaze DG, Skinner SA, Annese F, Baggett L, Barrish JO, Geerts SP, Percy AK. Age of diagnosis in Rett syndrome: patterns of recognition among diagnosticians and risk factors for late diagnosis. Pediatr Neurol. 2015 Jun; 52(6):585-91.e2. PMID: 25801175; PMCID: PMC4442062.
    24. Pitcher MR, Herrera JA, Buffington SA, Kochukov MY, Merritt JK, Fisher AR, Schanen NC, Costa-Mattioli M, Neul J. Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene. Hum Mol Genet. 2015 May 01; 24(9):2662-72. PMID: 25634563; PMCID: PMC4383870.
    25. Motil KJ, Barrish JO, Neul J, Glaze DG. Low bone mineral mass is associated with decreased bone formation and diet in girls with Rett syndrome. J Pediatr Gastroenterol Nutr. 2014 Sep; 59(3):386-92. PMID: 25144778; PMCID: PMC4144049.
    26. Killian JT, Lane JB, Cutter GR, Skinner SA, Kaufmann WE, Tarquinio DC, Glaze DG, Motil KJ, Neul J, Percy AK. Pubertal development in Rett syndrome deviates from typical females. Pediatr Neurol. 2014 Dec; 51(6):769-75. PMID: 25283752; PMCID: PMC4254166.
    27. Glasgow SM, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul J, Wegner M, Mohila C, Deneen B. Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct; 17(10):1322-9. PMID: 25151262; PMCID: PMC4313923.
    28. Neul J, Lane JB, Lee HS, Geerts S, Barrish JO, Annese F, Baggett LM, Barnes K, Skinner SA, Motil KJ, Glaze DG, Kaufmann WE, Percy AK. Developmental delay in Rett syndrome: data from the natural history study. J Neurodev Disord. 2014; 6(1):20. PMID: 25071871; PMCID: PMC4112822.
    29. Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, Chopra A, Probst FJ, Xia F, Yang Y, Werlin S, Eglite I, Kornejeva L, Bacino CA, Baldridge D, Neul J, Lehman EL, Larson A, Beuten J, Muzny DM, Jhangiani S. Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome. PLoS Genet. 2014 Mar; 10(3):e1004258. PMID: 24676022; PMCID: PMC3967950.
    30. Suter B, Treadwell-Deering D, Zoghbi HY, Glaze DG, Neul J. Brief report: MECP2 mutations in people without Rett syndrome. J Autism Dev Disord. 2014 Mar; 44(3):703-11. PMID: 23921973; PMCID: PMC3880396.
    31. Cuddapah VA, Pillai RB, Shekar KV, Lane JB, Motil KJ, Skinner SA, Tarquinio DC, Glaze DG, McGwin G, Kaufmann WE, Percy AK, Neul J, Olsen ML. Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome. J Med Genet. 2014 Mar; 51(3):152-8. PMID: 24399845; PMCID: PMC4403764.
    32. Ramirez JM, Ward CS, Neul J. Breathing challenges in Rett syndrome: lessons learned from humans and animal models. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):280-7. PMID: 23816600; PMCID: PMC3812329.
    33. Chapleau CA, Lane J, Kirwin SM, Schanen C, Vinette KM, Stubbolo D, MacLeod P, Glaze DG, Motil KJ, Neul J, Skinner SA, Kaufmann WE, Percy AK. Detection of rarely identified multiple mutations in MECP2 gene do not contribute to enhanced severity in Rett syndrome. Am J Med Genet A. 2013 Jul; 161A(7):1638-46. PMID: 23696494; PMCID: PMC3689857.
    34. Pitcher MR, Ward CS, Arvide EM, Chapleau CA, Pozzo-Miller L, Hoeflich A, Sivaramakrishnan M, Saenger S, Metzger F, Neul J. Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet. 2013 Jul 01; 22(13):2626-33. PMID: 23462290; PMCID: PMC3674803.
    35. Yang T, Ramocki MB, Neul J, Lu W, Roberts L, Knight J, Ward CS, Zoghbi HY, Kheradmand F, Corry DB. Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses. Sci Transl Med. 2012 Dec 05; 4(163):163ra158. PMID: 23220634; PMCID: PMC3628825.
    36. Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul J, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA. Preclinical research in Rett syndrome: setting the foundation for translational success. Dis Model Mech. 2012 Nov; 5(6):733-45. PMID: 23115203; PMCID: PMC3484856.
    37. Tarquinio DC, Motil KJ, Hou W, Lee HS, Glaze DG, Skinner SA, Neul J, Annese F, McNair L, Barrish JO, Geerts SP, Lane JB, Percy AK. Growth failure and outcome in Rett syndrome: specific growth references. Neurology. 2012 Oct 16; 79(16):1653-61. PMID: 23035069; PMCID: PMC3468773.
    38. Samaco RC, McGraw CM, Ward CS, Sun Y, Neul J, Zoghbi HY. Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies. Hum Mol Genet. 2013 Jan 01; 22(1):96-109. PMID: 23026749; PMCID: PMC3522402.
    39. Neul J. The relationship of Rett syndrome and MECP2 disorders to autism. Dialogues Clin Neurosci. 2012 Sep; 14(3):253-62. PMID: 23226951; PMCID: PMC3513680.
    40. Motil KJ, Caeg E, Barrish JO, Geerts S, Lane JB, Percy AK, Annese F, McNair L, Skinner SA, Lee HS, Neul J, Glaze DG. Gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):292-8. PMID: 22331013; PMCID: PMC3393805.
    41. McCauley MD, Wang T, Mike E, Herrera J, Beavers DL, Huang TW, Ward CS, Skinner S, Percy AK, Glaze DG, Wehrens XH, Neul J. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14; 3(113):113ra125. PMID: 22174313; PMCID: PMC3633081.
    42. Neul J. Unfolding neurodevelopmental disorders: the mystery of developing connections. Nat Med. 2011 Nov 02; 17(11):1353-5. PMID: 22064413; PMCID: PMC3629696.
    43. Motil KJ, Barrish JO, Lane J, Geerts SP, Annese F, McNair L, Percy AK, Skinner SA, Neul J, Glaze DG. Vitamin D deficiency is prevalent in girls and women with Rett syndrome. J Pediatr Gastroenterol Nutr. 2011 Nov; 53(5):569-74. PMID: 21637127; PMCID: PMC3638258.
    44. Ward CS, Arvide EM, Huang TW, Yoo J, Noebels JL, Neul J. MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan. J Neurosci. 2011 Jul 13; 31(28):10359-70. PMID: 21753013; PMCID: PMC3175623.
    45. Samaco RC, Neul J. Complexities of Rett syndrome and MeCP2. J Neurosci. 2011 Jun 01; 31(22):7951-9. PMID: 21632916; PMCID: PMC3127460.
    46. Percy AK, Neul J, Glaze DG, Motil KJ, Skinner SA, Khwaja O, Lee HS, Lane JB, Barrish JO, Annese F, McNair L, Graham J, Barnes K. Rett syndrome diagnostic criteria: lessons from the Natural History Study. Ann Neurol. 2010 Dec; 68(6):951-5. PMID: 21104896; PMCID: PMC3021984.
    47. Neul J, Kaufmann WE, Glaze DG, Christodoulou J, Clarke AJ, Bahi-Buisson N, Leonard H, Bailey ME, Schanen NC, Zappella M, Renieri A, Huppke P, Percy AK. Rett syndrome: revised diagnostic criteria and nomenclature. Ann Neurol. 2010 Dec; 68(6):944-50. PMID: 21154482; PMCID: PMC3058521.
    48. Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul J, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9. PMID: 21068835; PMCID: PMC3057962.
    49. Percy AK, Lee HS, Neul J, Lane JB, Skinner SA, Geerts SP, Annese F, Graham J, McNair L, Motil KJ, Barrish JO, Glaze DG. Profiling scoliosis in Rett syndrome. Pediatr Res. 2010 Apr; 67(4):435-9. PMID: 20032810; PMCID: PMC2852102.
    50. Neul J. Interested in a career as a clinician-scientist? Dis Model Mech. 2010 Mar-Apr; 3(3-4):125-30. PMID: 20212077.
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    51. Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul J. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21966-71. PMID: 20007372.
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    52. Glaze DG, Percy AK, Motil KJ, Lane JB, Isaacs JS, Schultz RJ, Barrish JO, Neul J, O'Brien WE, Smith EO. A study of the treatment of Rett syndrome with folate and betaine. J Child Neurol. 2009 May; 24(5):551-6. PMID: 19225139; PMCID: PMC2760386.
    53. Fyffe SL, Neul J, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron. 2008 Sep 25; 59(6):947-58. PMID: 18817733.
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    54. Samaco RC, Fryer JD, Ren J, Fyffe S, Chao HT, Sun Y, Greer JJ, Zoghbi HY, Neul J. A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum Mol Genet. 2008 Jun 15; 17(12):1718-27. PMID: 18321864.
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    55. del Gaudio D, Fang P, Scaglia F, Ward PA, Craigen WJ, Glaze DG, Neul J, Patel A, Lee JA, Irons M, Berry SA, Pursley AA, Grebe TA, Freedenberg D, Martin RA, Hsich GE, Khera JR, Friedman NR, Zoghbi HY, Eng CM, Lupski JR, Beaudet AL, Cheung SW, Roa BB. Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males. Genet Med. 2006 Dec; 8(12):784-92. PMID: 17172942.
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    56. Maricich SM, Neul J, Lotze TE, Cazacu AC, Uyeki TM, Demmler GJ, Clark GD. Neurologic complications associated with influenza A in children during the 2003-2004 influenza season in Houston, Texas. Pediatrics. 2004 Nov; 114(5):e626-33. PMID: 15520093.
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    57. Neul J, Zoghbi HY. Rett syndrome: a prototypical neurodevelopmental disorder. Neuroscientist. 2004 Apr; 10(2):118-28. PMID: 15070486.
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