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Jean Bernatchez

Title(s)Postdoctoral Scholar, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    McGill University, Montreal, CanadaB.Sc. (Hons.)2008Biochemistry
    McGill University, Montreal, CanadaPh.D.2015Biochemistry (Chemical Biology Graduate Option)

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Cancer Discov. 2020 Nov; 10(11):1722-1741. Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN. PMID: 32703768.
      View in: PubMed   Mentions:    Fields:    
    2. Insights gained into respiratory infection pathogenesis using lung tissue metabolomics. PLoS Pathog. 2020 07; 16(7):e1008662. Bernatchez JA, McCall LI. PMID: 32663224.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. Microorganisms. 2020 Mar 26; 8(4). Bernatchez JA, Chen E, Hull MV, McNamara CW, McKerrow JH, Siqueira-Neto JL. PMID: 32224991.
      View in: PubMed   Mentions:
    4. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem. 2020 03 26; 63(6):3298-3316. Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. PMID: 32125159.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Local Phenomena Shape Backyard Soil Metabolite Composition. Metabolites. 2020 Feb 29; 10(3). Nguyen TD, Lesani M, Forrest I, Lan Y, Dean DA, Gibaut QMR, Guo Y, Hossain E, Olvera M, Panlilio H, Parab AR, Wu C, Bernatchez JA, Cichewicz RH, McCall LI. PMID: 32121389.
      View in: PubMed   Mentions:
    6. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin avß5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
      View in: PubMed   Mentions: 9     Fields:    
    7. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):249-257. Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. PMID: 32184953.
      View in: PubMed   Mentions:
    8. Drugs for the Treatment of Zika Virus Infection. J Med Chem. 2020 01 23; 63(2):470-489. Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R. PMID: 31549836.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells. Viruses. 2019 04 20; 11(4). Bernatchez JA, Coste M, Beck S, Wells GA, Luna LA, Clark AE, Zhu Z, Hecht D, Rich JN, Sohl CD, Purse BW, Siqueira-Neto JL. PMID: 31010044.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Mechanism of Action of Methotrexate Against Zika Virus. Viruses. 2019 04 10; 11(4). Beck S, Zhu Z, Oliveira MF, Smith DM, Rich JN, Bernatchez JA, Siqueira-Neto JL. PMID: 30974762.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma. J Exp Med. 2019 05 06; 216(5):1071-1090. Mack SC, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN. PMID: 30948495.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. In vitro evaluation of the leishmanicidal potential of selected plant-derived extracts against Leishmania (Leishmania) amazonensis. Int. J. Complement. Alt. Med. 2019; 1(12):36-41. Souza JM, Candido ACBB, Pagotti MC, Dias HJ, Aguiar GP, Arantes AT, Cunha WR, Groppo M, Crotti AEM, Parreira RLT, Bernatchez JA, Magalhães LG.
    13. Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy. J Med Chem. 2019 04 11; 62(7):3171-3183. Luan Y, Li J, Bernatchez JA, Li R. PMID: 30418766.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus. Antimicrob Agents Chemother. 2018 10; 62(10). Bernatchez JA, Yang Z, Coste M, Li J, Beck S, Liu Y, Clark AE, Zhu Z, Luna LA, Sohl CD, Purse BW, Li R, Siqueira-Neto JL. PMID: 30061280.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. PMID: 30138453.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    16. Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle. Bioorg Med Chem. 2018 05 01; 26(8):1713-1726. Lacbay CM, Menni M, Bernatchez JA, Götte M, Tsantrizos YS. PMID: 29478802.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 10 03; 89(19):10414-10421. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. PMID: 28892370.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. A common anti-cytomegalovirus drug, ganciclovir, inhibits HIV-1 replication in human tissues ex vivo. AIDS. 2017 07 17; 31(11):1519-1528. Vanpouille C, Bernatchez JA, Lisco A, Arakelyan A, Saba E, Götte M, Margolis L. PMID: 28657962.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT. ACS Chem Biol. 2015 Sep 18; 10(9):2024-33. Yamada K, Wahba AS, Bernatchez JA, Ilina T, Martínez-Montero S, Habibian M, Deleavey GF, Götte M, Parniak MA, Damha MJ. PMID: 26131619.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3475-80. Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, Götte M, Maguire AR, Arnold E. PMID: 25733891.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16; 290(3):1474-84. Bernatchez JA, Paul R, Tchesnokov EP, Ngure M, Beilhartz GL, Berghuis AM, Lavoie R, Li L, Auger A, Melnyk RA, Grobler JA, Miller MD, Hazuda DJ, Hecht SM, Götte M. PMID: 25355312.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    22. Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase. Acta Clin Belg. 2014 Oct; 69(5):348-57. Megens S, De Wit S, Bernatchez J, Dekeersmaeker N, Vinken L, Covens K, Theys K, Camacho RJ, Vandamme AM, Götte M, Van Laethem K. PMID: 25103592.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA. J Biol Chem. 2014 May 16; 289(20):14399-411. Karam P, Powdrill MH, Liu HW, Vasquez C, Mah W, Bernatchez J, Götte M, Cosa G. PMID: 24692556.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    24. Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer. J Biol Chem. 2013 Jun 14; 288(24):17336-46. Ehteshami M, Nijhuis M, Bernatchez JA, Ablenas CJ, McCormick S, de Jong D, Jochmans D, Götte M. PMID: 23598281.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses. 2010 Oct; 2(10):2169-95. Powdrill MH, Bernatchez JA, Götte M. PMID: 21994615.
      View in: PubMed   Mentions: 27     Fields:    
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