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SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells. Signal Transduct Target Ther. 2023 Jul 14; 8(1):276.
Yang K, Liu S, Yan H, Lu W, Shan X, Chen H, Bao C, Feng H, Liao J, Liang S, Xu L, Tang H, Yuan JX, Zhong N, Wang J. PMID: 37452066; PMCID: PMC10349149.
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HumansAnimalsCells
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Revisiting the Role of KCNA5 in Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2023 May 18.
Ayon RJ, Yuan JX. PMID: 37201951.
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Humans
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Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice. Diab Vasc Dis Res. 2023 May-Jun; 20(3):14791641231173630.
Cabrera JT, Si R, Tsuji-Hosokawa A, Cai H, Yuan JX, Dillmann WH, Makino A. PMID: 37186669; PMCID: PMC10196148.
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AnimalsCells
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Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats. Br J Pharmacol. 2023 08; 180(16):2102-2119.
Zhang C, Zhang T, Xing Y, Lu W, Chen J, Luo X, Wu X, Liu S, Chen L, Zhang Z, Zhou D, Lin Z, Chen Y, Xiong M, Yuan JX, Yang K, Wang J. PMID: 36869838.
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AnimalsCells
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Pathogenic Mechanisms of Pulmonary Arterial Hypertension: Homeostasis Imbalance of Endothelium-Derived Relaxing and Contracting Factors. JACC Asia. 2022 Dec; 2(7):787-802.
Zhu J, Yang L, Jia Y, Balistrieri A, Fraidenburg DR, Wang J, Tang H, Yuan JX. PMID: 36713766; PMCID: PMC9877237.
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PubMed Mentions:
1
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Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood. Nat Commun. 2022 Nov 25; 13(1):7276.
Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX, An TS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Gräf S, Morrell NW, Wilkins MR, Lawrie A, Wang D, UK National PAH Cohort Study Consortium. PMID: 36433938; PMCID: PMC9700755.
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Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling. Physiol Rev. 2023 07 01; 103(3):1827-1897.
Balistrieri A, Makino A, Yuan JX. PMID: 36422993; PMCID: PMC10110735.
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5 Fields:
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HumansCells
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The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension. Hypertension. 2023 01; 80(1):70-83.
Bao C, Liang S, Han Y, Yang Z, Liu S, Sun Y, Zheng S, Li Y, Wang T, Gu Y, Wu K, Black SM, Wang J, Nawrocki ST, Carew JS, Yuan JX, Tang H. PMID: 36345832.
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1 Fields:
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HumansAnimalsCells
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Editorial: Calcium and pulmonary hypertension. Front Physiol. 2022; 13:1019158.
Li JF, Chen YQ, Wang L, Cao YS, Yuan JX. PMID: 36407003; PMCID: PMC9670137.
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MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension. Circ Res. 2022 Oct 28; 131(10):828-841.
Wang C, Xing Y, Zhang J, He M, Dong J, Chen S, Wu H, Huang HY, Chou CH, Bai L, He F, She J, Su A, Wang Y, Thistlethwaite PA, Huang HD, Yuan JX, Yuan ZY, Shyy JY. PMID: 36252121.
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PubMed Mentions:
2 Fields:
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HumansAnimalsCells
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Microbiome and metabolome dysbiosis of the gut-lung axis in pulmonary hypertension. Microbiol Res. 2022 Dec; 265:127205.
Chen J, Zhou D, Miao J, Zhang C, Li X, Feng H, Xing Y, Zhang Z, Bao C, Lin Z, Chen Y, Yuan JX, Sun D, Yang K, Wang J. PMID: 36202007.
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4 Fields:
Translation:
Animals
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Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Chest. 2023 01; 163(1):204-215.
Alotaibi M, Shao J, Pauciulo MW, Nichols WC, Hemnes AR, Malhotra A, Kim NH, Yuan JX, Fernandes T, Kerr KM, Alshawabkeh L, Desai AA, Bujor AM, Lafyatis R, Watrous JD, Long T, Cheng S, Chan SY, Jain M. PMID: 36087794; PMCID: PMC9899641.
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3 Fields:
Translation:
Humans
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Upregulation of mechanosensitive channel Piezo1 involved in high shear stress-induced pulmonary hypertension. Thromb Res. 2022 10; 218:52-63.
Chen J, Miao J, Zhou D, Liao J, Wang Z, Lin Z, Zhang C, Luo X, Li Y, Li X, Liu S, Xing Y, Zhang Z, Zhao M, Parmisano S, Chen Y, Yuan JX, Yang K, Sun D, Wang J. PMID: 35988445.
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1 Fields:
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AnimalsCells
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Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease. J Am Coll Cardiol. 2022 08 16; 80(7):697-718.
Hemnes AR, Leopold JA, Radeva MK, Beck GJ, Abidov A, Aldred MA, Barnard J, Rosenzweig EB, Borlaug BA, Chung WK, Comhair SAA, Desai AA, Dubrock HM, Erzurum SC, Finet JE, Frantz RP, Garcia JGN, Geraci MW, Gray MP, Grunig G, Hassoun PM, Highland KB, Hill NS, Hu B, Kwon DH, Jacob MS, Jellis CL, Larive AB, Lempel JK, Maron BA, Mathai SC, McCarthy K, Mehra R, Nawabit R, Newman JH, Olman MA, Park MM, Ramos JA, Renapurkar RD, Rischard FP, Sherer SG, Tang WHW, Thomas JD, Vanderpool RR, Waxman AB, Wilcox JD, Yuan JX, Horn EM, PVDOMICS Study Group. PMID: 35953136; PMCID: PMC9897285.
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PubMed Mentions:
6 Fields:
Translation:
HumansCTClinical Trials
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Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells. Am J Physiol Cell Physiol. 2022 10 01; 323(4):C959-C973.
Zhao T, Parmisano S, Soroureddin Z, Zhao M, Yung L, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35968892; PMCID: PMC9485000.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Time Domains of Hypoxia Responses and -Omics Insights. Front Physiol. 2022; 13:885295.
Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O'Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS. PMID: 36035495; PMCID: PMC9400701.
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4
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Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype. Sleep. 2022 06 13; 45(6).
Zhen X, Moya EA, Gautane M, Zhao H, Lawrence ES, Gu W, Barnes LA, Yuan JX, Jain PP, Xiong M, Catalan Serra P, Pham LV, Malhotra A, Simonson TS, Mesarwi OA. PMID: 34893914; PMCID: PMC9189937.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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NEDD9 provides mechanistic insight into the coagulopathy of COVID-19. Pulm Circ. 2022 Apr; 12(2):e12087.
Rizzo AN, Yuan JX. PMID: 35599982; PMCID: PMC9111000.
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Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability. Antioxidants (Basel). 2022 May 05; 11(5).
Liu Z, Zhang Y, Youn JY, Zhang Y, Makino A, Yuan JX, Cai H. PMID: 35624768; PMCID: PMC9137638.
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PubMed Mentions:
2
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JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension. Sci Transl Med. 2022 05 04; 14(643):eabl5471.
Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, Yuan JX, Shyy J, Thistlethwaite PA. PMID: 35507674.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Targeting ATP-Sensitive K+ Channels to Treat Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2022 05; 66(5):476-478.
Breen E, Yuan JX. PMID: 35238728; PMCID: PMC9116352.
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1 Fields:
Translation:
Humans
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Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex. Transl Res. 2022 09; 247:1-18.
Rafikov R, Rischard F, Vasilyev M, Varghese MV, Yuan JX, Desai AA, Garcia JGN, Rafikova O. PMID: 35405322; PMCID: PMC10062382.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia. Hum Mol Genet. 2022 03 31; 31(7):1130-1140.
Stobdan T, Jain PP, Xiong M, Bafna V, Yuan JX, Haddad GG. PMID: 34718575; PMCID: PMC8976430.
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AnimalsCells
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Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2022 05 01; 322(5):L737-L760.
Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 35318857; PMCID: PMC9076422.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 04 11; 57(7):839-853.e6.
Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. PMID: 35303432; PMCID: PMC9137452.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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In Vivo and Ex Vivo Experimental Approach for Studying Functional Role of Notch in Pulmonary Vascular Disease. Methods Mol Biol. 2022; 2472:209-220.
Jain PP, Hosokawa S, Babicheva A, Zhao T, Chen J, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35674903.
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AnimalsCells
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Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial. Lancet Respir Med. 2022 03; 10(3):267-277.
Sutharsan S, McKone EF, Downey DG, Duckers J, MacGregor G, Tullis E, Van Braeckel E, Wainwright CE, Watson D, Ahluwalia N, Bruinsma BG, Harris C, Lam AP, Lou Y, Moskowitz SM, Tian S, Yuan J, Waltz D, Mall MA, VX18-445-109 study group. PMID: 34942085.
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PubMed Mentions:
19 Fields:
Translation:
HumansCTClinical Trials
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Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood. Nat Commun. 2021 12 07; 12(1):7104.
Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX, An TS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Gräf S, Morrell NW, Wilkins MR, Lawrie A, Wang D, UK National PAH Cohort Study Consortium. PMID: 34876579; PMCID: PMC8651638.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist. Br J Pharmacol. 2022 03; 179(5):1065-1081.
Zheng Q, Lu W, Yan H, Duan X, Chen Y, Zhang C, Luo X, Chen J, Wang C, Liu S, Li Y, Tang H, Rahimi S, Rahimi S, Yuan JX, Zhong N, Yang K, Wang J. PMID: 34599843.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211059712.
Ahmed M, Zaghloul N, Zimmerman P, Casanova NG, Sun X, Song JH, Hernon VR, Sammani S, Rischard F, Rafikova O, Rafikov R, Makino A, Kempf CL, Camp SM, Wang J, Desai AA, Lussier Y, Yuan JX, Garcia JGN. PMID: 34790349; PMCID: PMC8591779.
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PubMed Mentions:
5
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HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes. JCI Insight. 2021 11 08; 6(21).
Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A. PMID: 34747371; PMCID: PMC8663561.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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TRPC6, a therapeutic target for pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1161-L1182.
Jain PP, Lai N, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34704831; PMCID: PMC8715021.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C1010-C1027.
Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 34669509; PMCID: PMC8714987.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211041512.
Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 34531976; PMCID: PMC8438952.
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4
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Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells. Front Physiol. 2021; 12:714785.
Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, Lai N, Zhao T, Hernandez M, Balistrieri A, Parmisano S, Simonson T, Breen E, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34408668; PMCID: PMC8364962.
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PubMed Mentions:
1
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Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 09; 178(17):3373-3394.
Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-Endothelial Cell Interaction in Pulmonary Hypertension. Am J Respir Crit Care Med. 2021 06 15; 203(12):1455-1458.
Wang J, Yang K, Yuan JX. PMID: 33770456; PMCID: PMC8483222.
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3 Fields:
Translation:
HumansCells
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Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients. Hypertension. 2021 06; 77(6):1974-1989.
Liao J, Lu W, Chen Y, Duan X, Zhang C, Luo X, Lin Z, Chen J, Liu S, Yan H, Chen Y, Feng H, Zhou D, Chen X, Zhang Z, Yang Q, Liu X, Tang H, Li J, Makino A, Yuan JX, Zhong N, Yang K, Wang J. PMID: 33813851.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021 04 30; 128(9):1323-1326.
Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33784827; PMCID: PMC8091897.
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PubMed Mentions:
190 Fields:
Translation:
AnimalsCells
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Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy. Antioxidants (Basel). 2021 Mar 11; 10(3).
Muralidharan P, Acosta MF, Gomez AI, Grijalva C, Tang H, Yuan JX, Mansour HM. PMID: 33799587; PMCID: PMC7998162.
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PubMed Mentions:
3
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IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. Blood. 2021 03 04; 137(9):1208-1218.
Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman E, Indik JH, Shi G, Christensen J, Gupta G, Hillery C, Kansal MM, Parikh DS, Zhou T, Yuan JX, Kanthi Y, Bronk P, Koren G, Kittles R, Duarte JD, Garcia JGN, Machado RF, Dudley SC, Choi BR, Desai AA. PMID: 33181835; PMCID: PMC7933768.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target. Int J Mol Sci. 2021 Feb 21; 22(4).
Babicheva A, Makino A, Yuan JX. PMID: 33670032; PMCID: PMC7926633.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension. J Am Heart Assoc. 2020 12 15; 9(24):e018327.
Si R, Zhang Q, Cabrera JTO, Zheng Q, Tsuji-Hosokawa A, Watanabe M, Hosokawa S, Xiong M, Jain PP, Ashton AW, Yuan JX, Wang J, Makino A. PMID: 33307937; PMCID: PMC7955394.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020968531.
Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. PMID: 33343881; PMCID: PMC7727059.
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PubMed Mentions:
6
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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv. 2020 Dec 04.
Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33300001; PMCID: PMC7724674.
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4
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Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020956592.
Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. PMID: 33282184; PMCID: PMC7691930.
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PubMed Mentions:
7
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Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox Biol. 2021 01; 38:101785.
Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 33221570; PMCID: PMC7691184.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery. Pulm Pharmacol Ther. 2020 10; 64:101975.
Gomez AI, Acosta MF, Muralidharan P, Yuan JX, Black SM, Hayes D, Mansour HM. PMID: 33137515; PMCID: PMC8923534.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172.
Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718; PMCID: PMC7834011.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension. Hypertension. 2020 11; 76(5):1589-1599.
Zhang C, Zhang T, Lu W, Duan X, Luo X, Liu S, Chen Y, Li Y, Chen J, Liao J, Zhou D, Chen X, Feng H, Gu G, Wang T, Tang H, Makino A, Zhong N, Yuan JX, Yang K, Wang J. PMID: 32921193.
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14 Fields:
Translation:
Humans
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Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep; 10(3):2045894020948470.
Wu K, Tang H, Lin R, Carr SG, Wang Z, Babicheva A, Ayon RJ, Jain PP, Xiong M, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Valdez-Jasso D, Simonson TS, Desai AA, Garcia JGN, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 33294172; PMCID: PMC7707860.
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PubMed Mentions:
8
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Hypoxia-induced pulmonary hypertension-Utilizing experiments of nature. Br J Pharmacol. 2021 01; 178(1):121-131.
Gassmann M, Cowburn A, Gu H, Li J, Rodriguez M, Babicheva A, Jain PP, Xiong M, Gassmann NN, Yuan JX, Wilkins MR, Zhao L. PMID: 32464698.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. 2020 09 22; 142(12):1190-1204.
Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, Lei Y, Chen S, Yin Q, Thistlethwaite PA, Wang J, Gong K, Yuan ZY, Yuan JX, Shyy JY. PMID: 32755395; PMCID: PMC7497891.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α. Am J Respir Cell Mol Biol. 2020 07; 63(1):92-103.
Sun X, Sun BL, Babicheva A, Vanderpool R, Oita RC, Casanova N, Tang H, Gupta A, Lynn H, Gupta G, Rischard F, Sammani S, Kempf CL, Moreno-Vinasco L, Ahmed M, Camp SM, Wang J, Desai AA, Yuan JX, Garcia JGN. PMID: 32142369; PMCID: PMC7328254.
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22 Fields:
Translation:
HumansAnimalsCells
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Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 06 01; 201(11):1407-1415.
Karnes JH, Wiener HW, Schwantes-An TH, Natarajan B, Sweatt AJ, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JX, Kittles R, de Jesus Perez V, Zamanian RT, Rischard F, Tiwari HK, Nichols WC, Benza RL, Desai AA. PMID: 31916850; PMCID: PMC7258627.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling? Am J Respir Crit Care Med. 2020 05 15; 201(10):1177-1179.
Goncharova EA, Simon MA, Yuan JX. PMID: 31968178; PMCID: PMC7233339.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes. Cardiovasc Res. 2020 05 01; 116(6):1186-1198.
Si R, Zhang Q, Tsuji-Hosokawa A, Watanabe M, Willson C, Lai N, Wang J, Dai A, Scott BT, Dillmann WH, Yuan JX, Makino A. PMID: 31504245; PMCID: PMC7177511.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension. Br J Pharmacol. 2020 06; 177(12):2743-2764.
Chen Y, Lu W, Yang K, Duan X, Li M, Chen X, Zhang J, Kuang M, Liu S, Wu X, Zou G, Liu C, Hong C, He W, Liao J, Hou C, Zhang Z, Zheng Q, Chen J, Zhang N, Tang H, Vanderpool RR, Desai AA, Rischard F, Black SM, Garcia JGN, Makino A, Yuan JX, Zhong N, Wang J. PMID: 31976548; PMCID: PMC7236078.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels. Am J Physiol Cell Physiol. 2020 05 01; 318(5):C954-C968.
Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX. PMID: 32186932; PMCID: PMC7294324.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis. J Heart Lung Transplant. 2020 04; 39(4):310-320.
Badagliacca R, Rischard F, Papa S, Kubba S, Vanderpool R, Yuan JX, Garcia JGN, Airhart S, Poscia R, Pezzuto B, Manzi G, Miotti C, Luongo F, Scoccia G, Sciomer S, Torre R, Fedele F, Vizza CD. PMID: 32061507.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. Br J Pharmacol. 2020 01; 177(2):314-327.
Zhang Q, Tsuji-Hosokawa A, Willson C, Watanabe M, Si R, Lai N, Wang Z, Yuan JX, Wang J, Makino A. PMID: 31503328; PMCID: PMC6989957.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition. Am J Respir Cell Mol Biol. 2020 01; 62(1):49-60.
Huang J, Lu W, Ouyang H, Chen Y, Zhang C, Luo X, Li M, Shu J, Zheng Q, Chen H, Chen J, Tang H, Sun D, Yuan JX, Yang K, Wang J. PMID: 31211918; PMCID: PMC6938136.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L10-L26.
Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX. PMID: 31553627; PMCID: PMC6985878.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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KCNK3 Channel: A New Player in the Field of Pulmonary Vascular Disease. Circ Res. 2019 09 13; 125(7):696-698.
Babicheva A, Zhao T, Yuan JX. PMID: 31513487.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13394-13403.
Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L, Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y. PMID: 31213542; PMCID: PMC6613097.
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PubMed Mentions:
59 Fields:
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HumansAnimalsCells
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EXPRESS: Surfing the Right Ventricular Pressure Waveform: Methods to assess Global, Systolic and Diastolic RV Function from a Clinical Right Heart Catheterization. Pulm Circ. 2019 Apr 29; 2045894019850993.
Vanderpool RR, Puri R, Osorio A, Wickstrom K, Desai A, Black S, Garcia JGN, Yuan J, Rischard F. PMID: 31032737; PMCID: PMC7031797.
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PubMed Mentions:
8
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Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension. Antioxid Redox Signal. 2019 11 01; 31(13):917-932.
Rafikov R, Nair V, Sinari S, Babu H, Sullivan JC, Yuan JX, Desai AA, Rafikova O. PMID: 30652485; PMCID: PMC6765065.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. Antioxid Redox Signal. 2019 10 20; 31(12):819-842.
Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 30623676; PMCID: PMC6751394.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Endothelial Notch1 in Pulmonary Hypertension. Circ Res. 2019 01 18; 124(2):176-179.
Babicheva A, Yuan JX. PMID: 30653427; PMCID: PMC6368966.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. JACC Basic Transl Sci. 2018 Dec; 3(6):744-762.
Tang H, Wu K, Wang J, Vinjamuri S, Gu Y, Song S, Wang Z, Zhang Q, Balistrieri A, Ayon RJ, Rischard F, Vanderpool R, Chen J, Zhou G, Desai AA, Black SM, Garcia JGN, Yuan JX, Makino A. PMID: 30623134; PMCID: PMC6314964.
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PubMed Mentions:
30
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Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase. mBio. 2018 12 18; 9(6).
Sutherland MC, Tran NL, Tillman DE, Jarodsky JM, Yuan J, Kranz RG. PMID: 30563894; PMCID: PMC6299221.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Pathophysiology of stroke: what do cells of the neurovascular unit have to do with it? Am J Physiol Cell Physiol. 2019 01 01; 316(1):C1.
O'Donnell ME, Yuan JX. PMID: 30462541.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L216-L228.
Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, Jiang Q, Li M, Chen Y, Carr SG, Wu K, Zhang Q, Balistrieri A, Wang C, Song S, Ayon RJ, Desai AA, Black SM, Garcia JGN, Makino A, Yuan JX, Lu W, Wang J. PMID: 30358436; PMCID: PMC6383500.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca2+ Channels. Biomed Res Int. 2018; 2018:4892349.
Miao R, Wan J, Liu J, Yuan JX, Wang J, Xie W, Zhai Z, Wang C. PMID: 30320134; PMCID: PMC6167576.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension. PLoS One. 2018; 13(8):e0203493.
Kurdyukov S, Eccles CA, Desai AA, Gonzalez-Garay M, Yuan JX, Garcia JGN, Rafikova O, Rafikov R. PMID: 30161219; PMCID: PMC6117081.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Pathophysiology of stroke: the many and varied contributions of brain microvasculature. Am J Physiol Cell Physiol. 2018 09 01; 315(3):C341-C342.
O'Donnell ME, Yuan JX. PMID: 30110563; PMCID: PMC6171040.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension. Cell Signal. 2018 11; 51:119-129.
Dai J, Zhou Q, Tang H, Chen T, Li J, Raychaudhuri P, Yuan JX, Zhou G. PMID: 30092353; PMCID: PMC6119636.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18. Am J Respir Cell Mol Biol. 2018 05; 58(5):614-624.
Gross CM, Kellner M, Wang T, Lu Q, Sun X, Zemskov EA, Noonepalle S, Kangath A, Kumar S, Gonzalez-Garay M, Desai AA, Aggarwal S, Gorshkov B, Klinger C, Verin AD, Catravas JD, Jacobson JR, Yuan JX, Rafikov R, Garcia JGN, Black SM. PMID: 29115856; PMCID: PMC5946326.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension. Hypertension. 2018 03; 71(3):518-529.
Song S, Carr SG, McDermott KM, Rodriguez M, Babicheva A, Balistrieri A, Ayon RJ, Wang J, Makino A, Yuan JX. PMID: 29358461; PMCID: PMC5955710.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C504-C517.
He X, Song S, Ayon RJ, Balisterieri A, Black SM, Makino A, Wier WG, Zang WJ, Yuan JX. PMID: 29351410; PMCID: PMC5966788.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217752912.
Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ. PMID: 29283043; PMCID: PMC5798691.
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PubMed Mentions:
65
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AJP-Cell Physiology begins landmark reviews in cell physiology: an editorial from the senior editors of AJP-Cell Physiology. Am J Physiol Cell Physiol. 2018 01 01; 314(1):C1-C2.
Delpire E, Hamilton KL, Hawke TJ, Isenberg JS, Lotersztajn S, Yuan JX, Adams JC. PMID: 29092820; PMCID: PMC6334934.
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PubMed Mentions: Fields:
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Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension? Am J Respir Cell Mol Biol. 2017 11; 57(5):506-508.
Vanderpool RR, Tang H, Rischard F, Yuan JX. PMID: 29090954; PMCID: PMC5705908.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ Res. 2017 10 27; 121(10):1136-1139.
Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA, PVDOMICS Study Group. PMID: 29074534; PMCID: PMC5685561.
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PubMed Mentions:
64 Fields:
Translation:
HumansCTClinical Trials
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Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2018 02 01; 314(2):L256-L275.
Tang H, Babicheva A, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX. PMID: 29074488; PMCID: PMC5866501.
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PubMed Mentions:
102 Fields:
Translation:
AnimalsCells
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Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol. 2017 Nov; 174(22):4155-4172.
Wu K, Zhang Q, Wu X, Lu W, Tang H, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z, McDermott KM, Balistrieri A, Wang C, Black SM, Garcia JGN, Makino A, Yuan JX, Wang J. PMID: 28849593; PMCID: PMC5659991.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension. Eur Respir J. 2017 08; 50(2).
Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP. PMID: 28838981; PMCID: PMC6330704.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension. Pulm Circ. 2017 Jul-Sep; 7(3):569-571.
Tang H, Vanderpool RR, Wang J, Yuan JX. PMID: 28895506; PMCID: PMC5841892.
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PubMed Mentions:
2
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The Pulmonary Vascular Research Institute celebrates its first decade. Pulm Circ. 2017 Apr-Jun; 7(2):283-284.
Yuan JX, Morrell NW, Stenmark KR, Lang IM, Butrous G, Reynolds ME. PMID: 28597776; PMCID: PMC5467951.
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Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension. Circulation. 2017 04 18; 135(16):1532-1546.
Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JGN, Machado RF. PMID: 28202489; PMCID: PMC5400780.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimals
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Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets. Am J Physiol Lung Cell Mol Physiol. 2017 04 01; 312(4):L452-L476.
Wang T, Gross C, Desai AA, Zemskov E, Wu X, Garcia AN, Jacobson JR, Yuan JX, Garcia JG, Black SM. PMID: 27979857; PMCID: PMC5407098.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol. 2017 03 01; 312(3):L309-L325.
Song S, Ayon RJ, Yamamura A, Yamamura H, Dash S, Babicheva A, Tang H, Sun X, Cordery AG, Khalpey Z, Black SM, Desai AA, Rischard F, McDermott KM, Garcia JG, Makino A, Yuan JX. PMID: 27979859; PMCID: PMC5374303.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016 12 05; 5(12).
Chen T, Zhou Q, Tang H, Bozkanat M, Yuan JX, Raj JU, Zhou G. PMID: 27919930; PMCID: PMC5210422.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Our readership grows by leaps and bounds. Pulm Circ. 2016 Dec; 6(4):405-406.
Yuan JX, Morrell NW, Stenmark KR, Butrous G, Reynolds ME. PMID: 28090284; PMCID: PMC5210069.
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Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series). Pulm Circ. 2016 Dec; 6(4):448-464.
Pullamsetti SS, Perros F, Chelladurai P, Yuan J, Stenmark K. PMID: 28090287; PMCID: PMC5210074.
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29
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Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. Free Radic Biol Med. 2017 01; 102:217-228.
Kumar S, Sun X, Noonepalle SK, Lu Q, Zemskov E, Wang T, Aggarwal S, Gross C, Sharma S, Desai AA, Hou Y, Dasarathy S, Qu N, Reddy V, Lee SG, Cherian-Shaw M, Yuan JX, Catravas JD, Rafikov R, Garcia JGN, Black SM. PMID: 27838434; PMCID: PMC5449193.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. Front Physiol. 2016; 7:517.
Smith KA, Ayon RJ, Tang H, Makino A, Yuan JX. PMID: 27867361; PMCID: PMC5095111.
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34
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Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 10 01; 311(4):H944-H957.
Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. PMID: 27591215; PMCID: PMC5114466.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms. Am J Respir Crit Care Med. 2016 08 15; 194(4):393-7.
Tang H, Desai AA, Yuan JX. PMID: 27525458; PMCID: PMC5003333.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol. 2016 08; 55(2):275-87.
Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM. PMID: 26959555; PMCID: PMC4979361.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Ryanodine receptor-2: a necessity for gating store-operated Ca2+ channels. Cardiovasc Res. 2016 07 01; 111(1):13-5.
Song S, Ayon RJ, Yuan JX. PMID: 27229459.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 07 01; 311(1):C136-49.
Jiang Q, Lu W, Yang K, Hadadi C, Fu X, Chen Y, Yun X, Zhang J, Li M, Xu L, Tang H, Yuan JX, Wang J, Sun D. PMID: 27194472; PMCID: PMC4967135.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L846-59.
Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg DR, Chen J, Gu Y, Pohl NM, Zhou T, Jiménez-Pérez L, Ayon RJ, Desai AA, Goltzman D, Rischard F, Khalpey Z, Black SM, Garcia JG, Makino A, Yuan JX. PMID: 26968768; PMCID: PMC4867349.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One. 2016; 11(3):e0150480.
Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM. PMID: 26937637; PMCID: PMC4777490.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimals
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Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. Free Radic Biol Med. 2016 06; 95:96-111.
Rafikova O, Rafikov R, Kangath A, Qu N, Aggarwal S, Sharma S, Desai J, Fields T, Ludewig B, Yuan JX, Jonigk D, Black SM. PMID: 26928584; PMCID: PMC5929487.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Gasping for answers. Focus on "Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia". Am J Physiol Cell Physiol. 2016 Mar 15; 310(6):C432-3.
Ayon RJ, Tang H, Yuan JX. PMID: 26843530; PMCID: PMC4796283.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol. 2016 Jan 15; 310(2):C99-114.
Song S, Jacobson KN, McDermott KM, Reddy SP, Cress AE, Tang H, Dudek SM, Black SM, Garcia JG, Makino A, Yuan JX. PMID: 26491047; PMCID: PMC4719033.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L1027-36.
Han Y, Cho YE, Ayon R, Guo R, Youssef KD, Pan M, Dai A, Yuan JX, Makino A. PMID: 26361875; PMCID: PMC4628985.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimals
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Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67.
Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. PMID: 25569851; PMCID: PMC4566064.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Redox Biol. 2015 Dec; 6:278-286.
Rafikov R, Sun X, Rafikova O, Louise Meadows M, Desai AA, Khalpey Z, Yuan JX, Fineman JR, Black SM. PMID: 26298201; PMCID: PMC4556771.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on "miR-223 reverses experimental pulmonary arterial hypertension". Am J Physiol Cell Physiol. 2015 Sep 15; 309(6):C361-2.
Smith KA, Yuan JX, Schumacker PT. PMID: 26201953.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Response to Letter Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". Circulation. 2015 Jul 14; 132(2):e17.
Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. PMID: 26169652; PMCID: PMC4624330.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis. EMBO Mol Med. 2015 Jun; 7(6):689-91.
Tang H, Ayon RJ, Yuan JX. PMID: 25851536; PMCID: PMC4459811.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015 Mar 15; 191(6):678-92.
Chen T, Zhou G, Zhou Q, Tang H, Ibe JC, Cheng H, Gou D, Chen J, Yuan JX, Raj JU. PMID: 25647182; PMCID: PMC4384776.
View in:
PubMed Mentions:
39 Fields:
Translation:
Animals
-
The rise and rise of Pulmonary Circulation. Pulm Circ. 2015 Mar; 5(1):1-2.
Yuan JX, Morrell NW, Westcott A, Butrous G. PMID: 25992266; PMCID: PMC4405727.
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PubMed Mentions:
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Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. Am J Physiol Cell Physiol. 2015 Apr 15; 308(8):C581-93.
Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX. PMID: 25673771; PMCID: PMC4398853.
View in:
PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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miRNA208/Mef2 and TNF-α in right ventricular dysfunction: the transition from hypertrophy to failure. Circ Res. 2015 Jan 02; 116(1):6-8.
Tang H, Fernandez RA, Yuan JX. PMID: 25552686; PMCID: PMC4890563.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
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Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15; 308(2):L208-20.
Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. PMID: 25416384; PMCID: PMC4338938.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 Nov 01; 190(9):1032-43.
Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. PMID: 25180446; PMCID: PMC4299585.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease. Circulation. 2014 Sep 30; 130(14):1179-91.
Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. PMID: 25062690; PMCID: PMC4182129.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension. PLoS One. 2014; 9(6):e101055.
Guo L, Yang Y, Liu J, Wang L, Li J, Wang Y, Liu Y, Gu S, Gan H, Cai J, Yuan JX, Wang J, Wang C. PMID: 24978044; PMCID: PMC4076206.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Aug 15; 307(4):C373-83.
Song S, Yamamura A, Yamamura H, Ayon RJ, Smith KA, Tang H, Makino A, Yuan JX. PMID: 24920677; PMCID: PMC4137136.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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[Effects of gender on severity and pulmonary artery vascular reactivity in chronic hypoxic pulmonary hypertension in mice]. Zhonghua Yi Xue Za Zhi. 2014 Jun 10; 94(22):1692-5.
Wan J, Yuan JX, Miao R, Zhai Z, Zhang M, Yang Y, Wang J, Wang C. PMID: 25151896.
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PubMed Mentions: Fields:
Translation:
Animals
-
Breaking barriers in obstructive sleep apnea. Focus on "Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation". Am J Physiol Cell Physiol. 2014 Apr 15; 306(8):C724-5.
Smith KA, Yuan JX. PMID: 24627556.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One. 2014; 9(3):e90544.
Zimnicka AM, Tang H, Guo Q, Kuhr FK, Oh MJ, Wan J, Chen J, Smith KA, Fraidenburg DR, Choudhury MS, Levitan I, Machado RF, Kaplan JH, Yuan JX. PMID: 24614111; PMCID: PMC3948681.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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The voice of pulmonary circulation. Pulm Circ. 2014 Mar; 4(1):1.
Yuan JX, Morrell NW, Holt C, Butrous G. PMID: 25006415; PMCID: PMC4070763.
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PubMed Mentions:
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Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C871-8.
Yamamura H, Yamamura A, Ko EA, Pohl NM, Smith KA, Zeifman A, Powell FL, Thistlethwaite PA, Yuan JX. PMID: 24573085; PMCID: PMC4010807.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Hypoxia-inducible factor-1α in pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):245-6.
Smith KA, Yuan JX. PMID: 24484328; PMCID: PMC3977736.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Deacetylation of MicroRNA-124 in fibroblasts: role in pulmonary hypertension. Circ Res. 2014 Jan 03; 114(1):5-8.
Pohl NM, Fernandez RA, Smith KA, Yuan JX. PMID: 24385500.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension. Pulm Circ. 2013 Sep; 3(3):654-64.
Wang L, Guo LJ, Liu J, Wang W, Yuan JX, Zhao L, Wang J, Wang C. PMID: 24618550; PMCID: PMC4070804.
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PubMed Mentions:
19
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Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension. Physiol Rep. 2013 Dec 01; 1(7):e00190.
Ogawa A, Firth AL, Ariyasu S, Yamadori I, Matsubara H, Song S, Fraidenburg DR, Yuan JX. PMID: 24744867; PMCID: PMC3970741.
View in:
PubMed Mentions:
13 Fields:
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Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice. Hypertens Res. 2014 Feb; 37(2):116-24.
Guo Q, Huang JA, Yamamura A, Yamamura H, Zimnicka AM, Fernandez R, Yuan JX. PMID: 24089267; PMCID: PMC5524516.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
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Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):609-18.
Ibe JC, Zhou Q, Chen T, Tang H, Yuan JX, Raj JU, Zhou G. PMID: 23668615; PMCID: PMC3824043.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Mutant hERG channel traffic jam. Focus on "Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum". Am J Physiol Cell Physiol. 2013 Nov 01; 305(9):C916-8.
Ayon RJ, Fernandez RA, Yuan JX. PMID: 23986200.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model. PLoS One. 2013; 8(8):e70176.
Chen J, Feng G, Guo Q, Wardenburg JB, Lin S, Inoshima I, Deaton R, Yuan JX, Garcia JG, Machado RF, Otto M, Wunderink RG. PMID: 23936388; PMCID: PMC3731344.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5.
Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. PMID: 23713908; PMCID: PMC3778734.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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Current and future therapeutic targets for pulmonary arterial hypertension. High Alt Med Biol. 2013 Jun; 14(2):134-43.
Fraidenburg D, Yuan J. PMID: 23795733.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15; 305(2):L154-64.
Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. PMID: 23686856; PMCID: PMC3726947.
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PubMed Mentions:
49 Fields:
Translation:
Animals
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Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension. Circ Res. 2013 Apr 12; 112(8):1091-3.
Fraidenburg DR, Yuan JX. PMID: 23580770; PMCID: PMC3728159.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction. Pulm Circ. 2013 Apr; 3(2):396-405.
Yoo HY, Zeifman A, Ko EA, Smith KA, Chen J, Machado RF, Zhao YY, Minshall RD, Yuan JX. PMID: 24015341; PMCID: PMC3757835.
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PubMed Mentions:
14
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Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol. 2013 Jun 01; 304(11):C1042-52.
Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. PMID: 23426966; PMCID: PMC3677177.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Human models for smooth muscle cell differentiation. Focus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells". Am J Physiol Cell Physiol. 2013 Feb 15; 304(4):C287-8.
Firth AL, Yuan JX. PMID: 23325406.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells. Circ Res. 2013 Feb 15; 112(4):640-50.
Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wan J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX. PMID: 23300272; PMCID: PMC3642037.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Readership: The heart of Pulmonary Circulation. Pulm Circ. 2013 Jan; 3(1):1-2.
Yuan JX, Morrell NW, Holt C, Butrous G. PMID: 23662169; PMCID: PMC3641711.
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PubMed Mentions:
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[Enhanced Ca2+-sensing receptor function in pulmonary hypertension]. Yakugaku Zasshi. 2013; 133(12):1351-9.
Yamamura A, Yamamura H, Yuan JX. PMID: 24292183.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension. J Signal Transduct. 2012; 2012:951497.
Fernandez RA, Sundivakkam P, Smith KA, Zeifman AS, Drennan AR, Yuan JX. PMID: 23056939; PMCID: PMC3465915.
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PubMed Mentions:
12
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H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on "Endogenous H2S is required for hypoxic sensing by carotid body glomus cells". Am J Physiol Cell Physiol. 2012 Nov 01; 303(9):C911-2.
Smith KA, Yuan JX. PMID: 22992680.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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STIM1 restores coronary endothelial function in type 1 diabetic mice. Circ Res. 2012 Oct 12; 111(9):1166-75.
Estrada IA, Donthamsetty R, Debski P, Zhou MH, Zhang SL, Yuan JX, Han W, Makino A. PMID: 22896585; PMCID: PMC3627729.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Are men at risk? The role of testosterone in cardiovascular morbidity. Pulm Circ. 2012 Jul; 2(3):275-7.
Sundivakkam PC, Desai AA, Smith KA, Yuan JX. PMID: 23130097; PMCID: PMC3487297.
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PubMed Mentions:
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CRACing the cluster: functionally active Orai1 channels in the absence of clustering with STIM1. Circ Res. 2012 Jun 22; 111(1):9-11.
Smith KA, Yuan JX. PMID: 22723218; PMCID: PMC3387275.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012 Aug 03; 111(4):469-81.
Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX. PMID: 22730443; PMCID: PMC3695473.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J. 2013 Feb; 41(2):462-8.
Lang IM, Pesavento R, Bonderman D, Yuan JX. PMID: 22700839.
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PubMed Mentions:
128 Fields:
Translation:
HumansAnimals
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A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med. 2012 Aug 15; 186(4):359-68.
Desai AA, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, Wade MS, Raghavachari N, Kato GJ, Peters-Lawrence MH, Thiruvoipati T, Turner K, Artz N, Huang Y, Patel AR, Yuan JX, Gordeuk VR, Lang RM, Garcia JG, Machado RF. PMID: 22679008; PMCID: PMC3443809.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. Am J Pathol. 2012 Jun; 180(6):2268-75.
Zhao YD, Cai L, Mirza MK, Huang X, Geenen DL, Hofmann F, Yuan JX, Zhao YY. PMID: 22632818; PMCID: PMC3717780.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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"Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cells. Focus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel". Am J Physiol Cell Physiol. 2012 Jul 15; 303(2):C113-4.
Firth AL, Yuan JX. PMID: 22572851.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Science is an endless frontier: Encouraging translational research in pulmonary vascular disease. Pulm Circ. 2012 Apr-Jun; 2(2):137-8.
Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22837853; PMCID: PMC3401866.
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PubMed Mentions:
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Thyroid hormone receptor-α and vascular function. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1346-52.
Makino A, Wang H, Scott BT, Yuan JX, Dillmann WH. PMID: 22322976; PMCID: PMC3361953.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8):H1546-62.
Kuhr FK, Smith KA, Song MY, Levitan I, Yuan JX. PMID: 22245772; PMCID: PMC3330808.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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A one-year-old baby… into the Year of the Dragon. Pulm Circ. 2012 Jan-Mar; 2(1):1-2.
Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22558513; PMCID: PMC3342737.
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PubMed Mentions:
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Identification of functional progenitor cells in the pulmonary vasculature. Pulm Circ. 2012 Jan-Mar; 2(1):84-100.
Firth AL, Yuan JX. PMID: 22558524; PMCID: PMC3342753.
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PubMed Mentions:
3
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PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C405-11.
Ogawa A, Firth AL, Smith KA, Maliakal MV, Yuan JX. PMID: 22031597; PMCID: PMC3328839.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury. Biochem Biophys Res Commun. 2011 Oct 07; 413(4):630-6.
Guo Q, Jin J, Yuan JX, Zeifman A, Chen J, Shen B, Huang J. PMID: 21939637.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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The world of pulmonary vascular disease. Pulm Circ. 2011 Jul-Sep; 1(3):303-4.
Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22140619; PMCID: PMC3224421.
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PubMed Mentions:
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Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr Physiol. 2011 Jul; 1(3):1555-602.
Makino A, Firth AL, Yuan JX. PMID: 23733654; PMCID: PMC5524522.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells. Pulm Circ. 2011 Jul-Sep; 1(3):405-18.
Yao W, Mu W, Zeifman A, Lofti M, Remillard CV, Makino A, Perkins DL, Garcia JG, Yuan JX, Zhang W. PMID: 22140631; PMCID: PMC3224433.
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PubMed Mentions:
3
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American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C253-4.
Arcangeli A, Yuan JX. PMID: 21613608.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Tension Measurement in Isolated Rat and Mouse Pulmonary Artery. Drug Discov Today Dis Models. 2010; 7(3-4):123-130.
Ko EA, Song MY, Donthamsetty R, Makino A, Yuan JX. PMID: 23175638; PMCID: PMC3501740.
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PubMed Mentions:
7
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Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts. J Am Coll Cardiol. 2011 May 03; 57(18):1846-55.
Tang T, Hammond HK, Firth A, Yang Y, Gao MH, Yuan JX, Lai NC. PMID: 21527160; PMCID: PMC3087976.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. Antioxid Redox Signal. 2011 Sep 15; 15(6):1549-65.
Song MY, Makino A, Yuan JX. PMID: 21126186; PMCID: PMC3151422.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Our journey continues. Pulm Circ. 2011 Apr-Jun; 1(2):133.
Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22034601; PMCID: PMC3198651.
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PubMed Mentions:
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Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells. Pulm Circ. 2011 Apr-Jun; 1(2):269-79.
Yamamura A, Yamamura H, Zeifman A, Yuan JX. PMID: 22034612; PMCID: PMC3198647.
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PubMed Mentions:
25
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Pulmonary Circulation : A new venue for communicating your findings, ideas and perspectives. Pulm Circ. 2011 Jan-Mar; 1(1):1-2.
Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22034592; PMCID: PMC3198629.
View in:
PubMed Mentions:
1
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STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension. Pulm Circ. 2011; 1(1):84-94.
Song MY, Makino A, Yuan JX. PMID: 21709766; PMCID: PMC3121304.
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PubMed Mentions:
51
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Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension. Pulm Circ. 2011 Jan-Mar; 1(1):111-4.
Kuang T, Wang J, Zeifman A, Pang B, Huang X, Burg ED, Yuan JX, Wang C. PMID: 22034597; PMCID: PMC3198628.
View in:
PubMed Mentions:
1
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Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels. Pulm Circ. 2011 Jan 01; 1(1):48-71.
Firth AL, Remillard CV, Platoshyn O, Fantozzi I, Ko EA, Yuan JX. PMID: 21927714; PMCID: PMC3173772.
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PubMed Mentions:
37
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Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):349-55.
Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK. PMID: 21195051; PMCID: PMC3219303.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol. 2011 Mar; 79(3):381-8.
Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK. PMID: 21127130; PMCID: PMC3061356.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Pulmonary hypertension in China: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl):69S-77S.
Zhai Z, Wang J, Zhao L, Yuan JX, Wang C. PMID: 20522582.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Idiopathic pulmonary arterial hypertension. Dis Model Mech. 2010 May-Jun; 3(5-6):268-73.
Firth AL, Mandel J, Yuan JX. PMID: 20427556; PMCID: PMC2860847.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Cell Physiol. 2010 May; 298(5):C1217-25.
Firth AL, Yao W, Ogawa A, Madani MM, Lin GY, Yuan JX. PMID: 20181931; PMCID: PMC2867379.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats. Pulm Pharmacol Ther. 2010 Oct; 23(5):456-64.
Kuang T, Wang J, Pang B, Huang X, Burg ED, Yuan JX, Wang C. PMID: 20188205; PMCID: PMC3108059.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2010 Apr; 298(4):L548-57.
Firth AL, Yao W, Remillard CV, Ogawa A, Yuan JX. PMID: 20139178; PMCID: PMC2853339.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Introduction to TRP channels: structure, function, and regulation. Adv Exp Med Biol. 2010; 661:99-108.
Song MY, Yuan JX. PMID: 20204725.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C496-509.
Burg ED, Platoshyn O, Tsigelny IF, Lozano-Ruiz B, Rana BK, Yuan JX. PMID: 20018952; PMCID: PMC2838577.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med. 2009 Nov; 15(11):1289-97.
Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW, Thistlethwaite PA. PMID: 19855400; PMCID: PMC2780347.
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PubMed Mentions:
168 Fields:
Translation:
HumansAnimalsCells
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Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases. Prog Biophys Mol Biol. 2010 Sep; 103(1):95-101.
Ko EA, Park WS, Firth AL, Kim N, Yuan JX, Han J. PMID: 19835907.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann N Y Acad Sci. 2009 Oct; 1177:101-11.
Firth AL, Platoshyn O, Brevnova EE, Burg ED, Powell F, Haddad GH, Yuan JX. PMID: 19845612.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L666-76.
Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite PA, Yuan JX. PMID: 19633069; PMCID: PMC2770792.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest. 2009 Jul; 119(7):2009-18.
Zhao YY, Zhao YD, Mirza MK, Huang JH, Potula HH, Vogel SM, Brovkovych V, Yuan JX, Wharton J, Malik AB. PMID: 19487814; PMCID: PMC2701851.
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PubMed Mentions:
154 Fields:
Translation:
HumansAnimalsCells
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Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S10-S19.
Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M. PMID: 19555853.
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PubMed Mentions:
320 Fields:
Translation:
HumansAnimals
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Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S20-S31.
Morrell NW, Adnot S, Archer SL, Dupuis J, Lloyd Jones P, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. PMID: 19555855; PMCID: PMC2790324.
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PubMed Mentions:
327 Fields:
Translation:
HumansAnimalsCells
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A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009 May 05; 119(17):2313-22.
Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX. PMID: 19380626; PMCID: PMC2749566.
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PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L979-86.
Firth AL, Yau J, White A, Chiles PG, Marsh JJ, Morris TA, Yuan JX. PMID: 19363122; PMCID: PMC2692802.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L870-8.
Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX. PMID: 19286928; PMCID: PMC2692803.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Bringing down the ROS: a new therapeutic approach for PPHN. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L976-8.
Firth AL, Yuan JX. PMID: 18931050; PMCID: PMC2654816.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1499-509.
Rao JN, Liu SV, Zou T, Liu L, Xiao L, Zhang X, Bellavance E, Yuan JX, Wang JY. PMID: 18923057; PMCID: PMC2603560.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1048-55.
Sacks RS, Firth AL, Remillard CV, Agange N, Yau J, Ko EA, Yuan JX. PMID: 18836030; PMCID: PMC2604792.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135.
Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546; PMCID: PMC2519786.
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PubMed Mentions:
129 Fields:
Translation:
HumansAnimalsCells
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Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L648-57.
Ogawa A, Firth AL, Yao W, Rubin LJ, Yuan JX. PMID: 18708631; PMCID: PMC2575943.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1529-38.
Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX. PMID: 18689502; PMCID: PMC2593496.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C221-30.
Makino A, Platoshyn O, Suarez J, Yuan JX, Dillmann WH. PMID: 18463230; PMCID: PMC2493564.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208.
Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JX. PMID: 18432456; PMCID: PMC5524512.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 01; 117(1):61-9.
Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. PMID: 18071070.
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PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
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Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H220-8.
Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX. PMID: 17982012.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L952-9.
Wu W, Platoshyn O, Firth AL, Yuan JX. PMID: 17693484.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). Biol Cell. 2007 Aug; 99(8):433-44.
Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH. PMID: 17388782.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C928-37.
Ko EA, Burg ED, Platoshyn O, Msefya J, Firth AL, Yuan JX. PMID: 17581857.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Heterogeneity of hypoxia-mediated decrease in I(K(V)) and increase in [Ca2+](cyt) in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L402-16.
Platoshyn O, Yu Y, Ko EA, Remillard CV, Yuan JX. PMID: 17526598.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Point:Counterpoint "Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction". J Appl Physiol (1985). 2007 05; 102(5):2078; discussion 2080.
Yuan JX. PMID: 17549820.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9.
Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. PMID: 17470567.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77.
Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. PMID: 17381514.
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PubMed Mentions:
74 Fields:
Translation:
HumansCells
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Cardiac L-arginine transport: the CAT is back. J Physiol. 2007 May 01; 580(Pt.3):699-700.
Remillard CV, Yuan JX. PMID: 17363379; PMCID: PMC2075442.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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TRP channels in hypertension. Biochim Biophys Acta. 2007 Aug; 1772(8):895-906.
Firth AL, Remillard CV, Yuan JX. PMID: 17399958; PMCID: PMC2025589.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007 May; 292(5):C1837-53.
Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O'connor DT, Yuan JX. PMID: 17267549.
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PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007 Jun; 292(6):C2297-305.
Zhang S, Dong H, Rubin LJ, Yuan JX. PMID: 17192285.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10.
Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. PMID: 17189322.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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TRP channels, CCE, and the pulmonary vascular smooth muscle. Microcirculation. 2006 Dec; 13(8):671-92.
Remillard CV, Yuan JX. PMID: 17085427.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels. Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3):L685-98.
Schach C, Xu M, Platoshyn O, Keller SH, Yuan JX. PMID: 17098807.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303.
Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. PMID: 16980375.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Transient receptor potential channels and caveolin-1: good friends in tight spaces. Mol Pharmacol. 2006 Oct; 70(4):1151-4.
Remillard CV, Yuan JX. PMID: 16873578.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L993-1004.
Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. PMID: 16815889.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Molecular biology of chronic thromboembolic pulmonary hypertension. Semin Thorac Cardiovasc Surg. 2006; 18(3):265-76.
Sacks RS, Remillard CV, Agange N, Auger WR, Thistlethwaite PA, Yuan JX. PMID: 17185190.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):192-208.
Murray F, Insel PA, Yuan JX. PMID: 16364695.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G782-92.
Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Marasa BS, Turner DJ, Yuan JX, Wang JY. PMID: 16282360.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C907-16.
Platoshyn O, Brevnova EE, Burg ED, Yu Y, Remillard CV, Yuan JX. PMID: 16236819; PMCID: PMC1363730.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension. Exp Lung Res. 2005 Oct; 31(8):783-806.
Fantozzi I, Huang W, Zhang J, Zhang S, Platoshyn O, Remillard CV, Thistlethwaite PA, Yuan JX. PMID: 16368652; PMCID: PMC1409757.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C325-36.
Mauban JR, Wilkinson K, Schach C, Yuan JX. PMID: 16162658; PMCID: PMC1351365.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells. Pflugers Arch. 2005 Nov; 451(2):380-387.
Platoshyn O, Remillard CV, Fantozzi I, Sison T, Yuan JX. PMID: 16052353; PMCID: PMC1351366.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2356-63.
Iwata M, Cowling RT, Gurantz D, Moore C, Zhang S, Yuan JX, Greenberg BH. PMID: 16024575.
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PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you? Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L789-92.
Remillard CV, Yuan JX. PMID: 15821019.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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ClC-3: more than just a volume-sensitive Cl- channel. Br J Pharmacol. 2005 May; 145(1):1-2.
Remillard CV, Yuan JX. PMID: 15723095; PMCID: PMC1576112.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53.
Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. PMID: 15703750; PMCID: PMC5578466.
View in:
PubMed Mentions:
473 Fields:
Translation:
HumansAnimalsCells
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Pathogenesis of pulmonary arterial hypertension: the need for multiple hits. Circulation. 2005 Feb 08; 111(5):534-8.
Yuan JX, Rubin LJ. PMID: 15699271.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways. Cell Biochem Biophys. 2005; 43(3):365-77.
Keller SH, Platoshyn O, Yuan JX. PMID: 16244363.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis. Cell Biochem Biophys. 2005; 42(1):41-53.
Tsigelny I, Hotchko M, Yuan JX, Keller SH. PMID: 15673927.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Hypoxic pulmonary vasoconstriction: role of ion channels. J Appl Physiol (1985). 2005 Jan; 98(1):415-20.
Mauban JR, Remillard CV, Yuan JX. PMID: 15591311.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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High altitude pulmonary hypertension: role of K+ and Ca2+ channels. High Alt Med Biol. 2005; 6(2):133-46.
Remillard CV, Yuan JX. PMID: 16060848; PMCID: PMC1351363.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2005 Feb; 288(2):C245-52.
Zhang S, Yuan JX, Barrett KE, Dong H. PMID: 15456699.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13861-6.
Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. PMID: 15358862; PMCID: PMC518765.
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PubMed Mentions:
194 Fields:
Translation:
HumansCells
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Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension. Microvasc Res. 2004 Sep; 68(2):75-103.
Mandegar M, Fung YC, Huang W, Remillard CV, Rubin LJ, Yuan JX. PMID: 15313118.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
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Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1101-7.
Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite PA, Rubin LJ, Yuan JX. PMID: 15317671.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Molecular biology of primary pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):417-29, vi.
Mandegar M, Thistlethwaite PA, Yuan JX. PMID: 15302361.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1192-201.
Zhang S, Remillard CV, Fantozzi I, Yuan JX. PMID: 15229105.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L962-9.
Kunichika N, Yu Y, Remillard CV, Platoshyn O, Zhang S, Yuan JX. PMID: 15220115.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Overexpression of human KCNA5 increases IK V and enhances apoptosis. Am J Physiol Cell Physiol. 2004 Sep; 287(3):C715-22.
Brevnova EE, Platoshyn O, Zhang S, Yuan JX. PMID: 15140747.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci. 2004 Apr; 19:44-50.
Landsberg JW, Yuan JX. PMID: 15016901.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimals
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Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L226-38.
Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. PMID: 15047570.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Activation of K+ channels: an essential pathway in programmed cell death. Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L49-67.
Remillard CV, Yuan JX. PMID: 14656699.
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PubMed Mentions:
77 Fields:
Translation:
HumansAnimals
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Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1233-45.
Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JX. PMID: 12909593.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L740-54.
Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX. PMID: 12740218.
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PubMed Mentions:
90 Fields:
Translation:
HumansCells
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Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med. 2003 Feb 06; 348(6):500-9.
Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethwaite PA. PMID: 12571257.
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PubMed Mentions:
87 Fields:
Translation:
HumansCells
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PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol. 2003 Feb; 284(2):C316-30.
Yu Y, Sweeney M, Zhang S, Platoshyn O, Landsberg J, Rothman A, Yuan JX. PMID: 12529250.
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PubMed Mentions:
126 Fields:
Translation:
AnimalsCells
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Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents. Am J Physiol Cell Physiol. 2003 Jun; 284(6):C1405-10.
Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX. PMID: 12734105.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C848-59.
Rao JN, Guo X, Liu L, Zou T, Murthy KS, Yuan JX, Wang JY. PMID: 12466151.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Cytochrome c activates K+ channels before inducing apoptosis. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1298-305.
Platoshyn O, Zhang S, McDaniel SS, Yuan JX. PMID: 12225992.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J Appl Physiol (1985). 2002 Apr; 92(4):1594-602.
Sweeney M, McDaniel SS, Platoshyn O, Zhang S, Yu Y, Lapp BR, Zhao Y, Thistlethwaite PA, Yuan JX. PMID: 11896026.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding. Am J Physiol Cell Physiol. 2002 Apr; 282(4):C885-98.
Rao JN, Platoshyn O, Li L, Guo X, Golovina VA, Yuan JX, Wang JY. PMID: 11880277.
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Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H184-93.
Krick S, Platoshyn O, Sweeney M, McDaniel SS, Zhang S, Rubin LJ, Yuan JX. PMID: 11748062.
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