Jason Yuan

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Peking Union Medical College, Beijing, ChinaPhD05/1993Cardiovascular Physiology
    Suzhou Medical College, Suzhou, ChinaMD07/1983
    Collapse Awards and Honors
    The Francis Families Foundation1994  - 1997Parker B. Francis Fellowship
    The American Physiological Society1995Giles F. Filley Memorial Award
    American Heart Association1995Cournand and Comroe Young Investigator Award (Winner)
    American Heart Association1996Best Abstract Award
    American Heart Association1998  - 2003Established Investigator Award
    American Heart Association2003Fellow
    American Society for Clinical Investigation2007Elected Member
    American Association for the Advancement of Science2007Fellow
    John Simon Guggenheim Memorial Foundation2008Guggenheim Fellowship Award
    American Thoracic Society2011Estelle Grover Lecturer
    Pulmonary Vascular Research Institute2012PVRI Achievement Award
    Association of American Physicians2013Elected Member
    American Heart Association2017Kenneth D. Bloch Memorial Lecturer
    The American Physiological Society2018Robert M. Berne Distinguished Lectureship
    American Thoracic Society2019Leadership Award
    The American Physiological Society2019Fellow (FAPS)

    Collapse Research 
    Collapse Research Activities and Funding
    Ion Channels and Membrane Receptors in Pulmonary Arterial Hypertension
    NIH R35HL135807Jan 15, 2017 - Dec 31, 2023
    Role: Principal Investigator
    Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertension
    NIH U01HL125208Sep 15, 2014 - Jul 31, 2020
    Role: Co-Principal Investigator
    Molecular mechanisms of downregulated Kv channels in IPAH: Role of microRNA
    NIH R01HL115014Sep 1, 2012 - May 31, 2017
    Role: Principal Investigator
    2008 Grover Conference on Pulmonary Vascular Pathobiology
    NIH R13HL092781Sep 10, 2008 - Sep 14, 2008
    Role: Principal Investigator
    SNPs in Idopathic Pulmonary Artierial Hypertension
    NIH R21HL080033May 10, 2005 - Apr 30, 2008
    Role: Principal Investigator
    Training in Mechanisms of Cardiovascular Diseases
    NIH T32HL072742Aug 1, 2003 - Jul 31, 2015
    Role: Principal Investigator
    Calcium Signaling in Pulmonary Arterial Hypertension: Role of CaSR and TRPC6
    NIH R01HL066012Dec 1, 2000 - May 31, 2017
    Role: Principal Investigator
    Cellular Mechanisms of PPH: Role of K+ Channels
    NIH R01HL064945Jul 15, 1999 - Jun 30, 2008
    Role: Principal Investigator
    Ion Channels and Pulmonary Vascular Tone
    NIH R01HL054043Apr 1, 1995 - Jun 30, 2010
    Role: Principal Investigator
    ION CHANNELS AND PULMONARY VASCULAR TONE
    NIH R29HL054043Apr 1, 1995 - Mar 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Airway Delivery of Streptococcus Salivarius is Sufficient to Induce Experimental Pulmonary Hypertension in Rat. Br J Pharmacol. 2023 Mar 04. Zhang C, Zhang T, Xing Y, Lu W, Chen J, Luo X, Wu X, Liu S, Chen L, Zhang Z, Zhou D, Lin Z, Chen Y, Xiong M, Yuan JX, Yang K, Wang J. PMID: 36869838.
      View in: PubMed   Mentions:    Fields:    
    2. Pathogenic Mechanisms of Pulmonary Arterial Hypertension: Homeostasis Imbalance of Endothelium-Derived Relaxing and Contracting Factors. JACC Asia. 2022 Dec; 2(7):787-802. Zhu J, Yang L, Jia Y, Balistrieri A, Fraidenburg DR, Wang J, Tang H, Yuan JX. PMID: 36713766; PMCID: PMC9877237.
      View in: PubMed   Mentions:
    3. Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood. Nat Commun. 2022 Nov 25; 13(1):7276. Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX, An TS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Gr?f S, Morrell NW, Wilkins MR, Lawrie A, Wang D, UK National PAH Cohort Study Consortium. PMID: 36433938; PMCID: PMC9700755.
      View in: PubMed   Mentions:    Fields:    
    4. Pathophysiology and Pathogenic Mechanisms of Pulmonary Hypertension: Role of Membrane Receptors, Ion Channels and Ca2+ Signaling. Physiol Rev. 2022 Nov 24. Balistrieri A, Makino A, Yuan JX. PMID: 36422993.
      View in: PubMed   Mentions: 1     Fields:    
    5. The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension. Hypertension. 2023 01; 80(1):70-83. Bao C, Liang S, Han Y, Yang Z, Liu S, Sun Y, Zheng S, Li Y, Wang T, Gu Y, Wu K, Black SM, Wang J, Nawrocki ST, Carew JS, Yuan JX, Tang H. PMID: 36345832.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Editorial: Calcium and pulmonary hypertension. Front Physiol. 2022; 13:1019158. Li JF, Chen YQ, Wang L, Cao YS, Yuan JX. PMID: 36407003; PMCID: PMC9670137.
      View in: PubMed   Mentions:
    7. MED1 Regulates BMP/TGF-� in Endothelium: Implication for Pulmonary Hypertension. Circ Res. 2022 10 28; 131(10):828-841. Wang C, Xing Y, Zhang J, He M, Dong J, Chen S, Wu H, Huang HY, Chou CH, Bai L, He F, She J, Su A, Wang Y, Thistlethwaite PA, Huang HD, Yuan JX, Yuan ZY, Shyy JY. PMID: 36252121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Microbiome and metabolome dysbiosis of the gut-lung axis in pulmonary hypertension. Microbiol Res. 2022 Dec; 265:127205. Chen J, Zhou D, Miao J, Zhang C, Li X, Feng H, Xing Y, Zhang Z, Bao C, Lin Z, Chen Y, Yuan JX, Sun D, Yang K, Wang J. PMID: 36202007.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Chest. 2023 01; 163(1):204-215. Alotaibi M, Shao J, Pauciulo MW, Nichols WC, Hemnes AR, Malhotra A, Kim NH, Yuan JX, Fernandes T, Kerr KM, Alshawabkeh L, Desai AA, Bujor AM, Lafyatis R, Watrous JD, Long T, Cheng S, Chan SY, Jain M. PMID: 36087794; PMCID: PMC9899641.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Upregulation of mechanosensitive channel Piezo1 involved in high shear stress-induced pulmonary hypertension. Thromb Res. 2022 Oct; 218:52-63. Chen J, Miao J, Zhou D, Liao J, Wang Z, Lin Z, Zhang C, Luo X, Li Y, Li X, Liu S, Xing Y, Zhang Z, Zhao M, Parmisano S, Chen Y, Yuan JX, Yang K, Sun D, Wang J. PMID: 35988445.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease. J Am Coll Cardiol. 2022 08 16; 80(7):697-718. Hemnes AR, Leopold JA, Radeva MK, Beck GJ, Abidov A, Aldred MA, Barnard J, Rosenzweig EB, Borlaug BA, Chung WK, Comhair SAA, Desai AA, Dubrock HM, Erzurum SC, Finet JE, Frantz RP, Garcia JGN, Geraci MW, Gray MP, Grunig G, Hassoun PM, Highland KB, Hill NS, Hu B, Kwon DH, Jacob MS, Jellis CL, Larive AB, Lempel JK, Maron BA, Mathai SC, McCarthy K, Mehra R, Nawabit R, Newman JH, Olman MA, Park MM, Ramos JA, Renapurkar RD, Rischard FP, Sherer SG, Tang WHW, Thomas JD, Vanderpool RR, Waxman AB, Wilcox JD, Yuan JX, Horn EM, PVDOMICS Study Group. PMID: 35953136; PMCID: PMC9897285.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    12. Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells. Am J Physiol Cell Physiol. 2022 Oct 01; 323(4):C959-C973. Zhao T, Parmisano S, Soroureddin Z, Zhao M, Yung L, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35968892; PMCID: PMC9485000.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Time Domains of Hypoxia Responses and -Omics Insights. Front Physiol. 2022; 13:885295. Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O'Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, V?zquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS. PMID: 36035495; PMCID: PMC9400701.
      View in: PubMed   Mentions: 1  
    14. Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype. Sleep. 2022 06 13; 45(6). Zhen X, Moya EA, Gautane M, Zhao H, Lawrence ES, Gu W, Barnes LA, Yuan JX, Jain PP, Xiong M, Catalan Serra P, Pham LV, Malhotra A, Simonson TS, Mesarwi OA. PMID: 34893914; PMCID: PMC9189937.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    15. NEDD9 provides mechanistic insight into the coagulopathy of COVID-19. Pulm Circ. 2022 Apr; 12(2):e12087. Rizzo AN, Yuan JX. PMID: 35599982; PMCID: PMC9111000.
      View in: PubMed   Mentions:
    16. Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability. Antioxidants (Basel). 2022 May 05; 11(5). Liu Z, Zhang Y, Youn JY, Zhang Y, Makino A, Yuan JX, Cai H. PMID: 35624768; PMCID: PMC9137638.
      View in: PubMed   Mentions:
    17. JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension. Sci Transl Med. 2022 05 04; 14(643):eabl5471. Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, Yuan JX, Shyy J, Thistlethwaite PA. PMID: 35507674.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Targeting ATP-Sensitive K+ Channels to Treat Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2022 05; 66(5):476-478. Breen E, Yuan JX. PMID: 35238728; PMCID: PMC9116352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex. Transl Res. 2022 09; 247:1-18. Rafikov R, Rischard F, Vasilyev M, Varghese MV, Yuan JX, Desai AA, Garcia JGN, Rafikova O. PMID: 35405322.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia. Hum Mol Genet. 2022 03 31; 31(7):1130-1140. Stobdan T, Jain PP, Xiong M, Bafna V, Yuan JX, Haddad GG. PMID: 34718575; PMCID: PMC8976430.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2022 05 01; 322(5):L737-L760. Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 35318857; PMCID: PMC9076422.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 04 11; 57(7):839-853.e6. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. PMID: 35303432; PMCID: PMC9137452.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. In Vivo and Ex Vivo Experimental Approach for Studying Functional Role of Notch in Pulmonary Vascular Disease. Methods Mol Biol. 2022; 2472:209-220. Jain PP, Hosokawa S, Babicheva A, Zhao T, Chen J, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35674903.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    24. Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial. Lancet Respir Med. 2022 03; 10(3):267-277. Sutharsan S, McKone EF, Downey DG, Duckers J, MacGregor G, Tullis E, Van Braeckel E, Wainwright CE, Watson D, Ahluwalia N, Bruinsma BG, Harris C, Lam AP, Lou Y, Moskowitz SM, Tian S, Yuan J, Waltz D, Mall MA, VX18-445-109 study group. PMID: 34942085.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    25. Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood. Nat Commun. 2021 12 07; 12(1):7104. Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX, An TS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Gr?f S, Morrell NW, Wilkins MR, Lawrie A, Wang D, UK National PAH Cohort Study Consortium. PMID: 34876579; PMCID: PMC8651638.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Established pulmonary hypertension in rats was reversed by a combination of a HIF-2a antagonist and a p53 agonist. Br J Pharmacol. 2022 03; 179(5):1065-1081. Zheng Q, Lu W, Yan H, Duan X, Chen Y, Zhang C, Luo X, Chen J, Wang C, Liu S, Li Y, Tang H, Rahimi S, Rahimi S, Yuan JX, Zhong N, Yang K, Wang J. PMID: 34599843.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211059712. Ahmed M, Zaghloul N, Zimmerman P, Casanova NG, Sun X, Song JH, Hernon VR, Sammani S, Rischard F, Rafikova O, Rafikov R, Makino A, Kempf CL, Camp SM, Wang J, Desai AA, Lussier Y, Yuan JX, Garcia JGN. PMID: 34790349; PMCID: PMC8591779.
      View in: PubMed   Mentions: 5  
    28. HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes. JCI Insight. 2021 11 08; 6(21). Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A. PMID: 34747371; PMCID: PMC8663561.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    29. TRPC6, a therapeutic target for pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1161-L1182. Jain PP, Lai N, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34704831; PMCID: PMC8715021.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C1010-C1027. Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 34669509; PMCID: PMC8714987.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    31. Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211041512. Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 34531976; PMCID: PMC8438952.
      View in: PubMed   Mentions: 3  
    32. Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells. Front Physiol. 2021; 12:714785. Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, Lai N, Zhao T, Hernandez M, Balistrieri A, Parmisano S, Simonson T, Breen E, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34408668; PMCID: PMC8364962.
      View in: PubMed   Mentions: 1  
    33. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 09; 178(17):3373-3394. Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155; PMCID: PMC9792225.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    34. NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-Endothelial Cell Interaction in Pulmonary Hypertension. Am J Respir Crit Care Med. 2021 06 15; 203(12):1455-1458. Wang J, Yang K, Yuan JX. PMID: 33770456; PMCID: PMC8483222.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients. Hypertension. 2021 06; 77(6):1974-1989. Liao J, Lu W, Chen Y, Duan X, Zhang C, Luo X, Lin Z, Chen J, Liu S, Yan H, Chen Y, Feng H, Zhou D, Chen X, Zhang Z, Yang Q, Liu X, Tang H, Li J, Makino A, Yuan JX, Zhong N, Yang K, Wang J. PMID: 33813851.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    36. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021 04 30; 128(9):1323-1326. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33784827; PMCID: PMC8091897.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    37. Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy. Antioxidants (Basel). 2021 Mar 11; 10(3). Muralidharan P, Acosta MF, Gomez AI, Grijalva C, Tang H, Yuan JX, Mansour HM. PMID: 33799587; PMCID: PMC7998162.
      View in: PubMed   Mentions: 2  
    38. IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. Blood. 2021 03 04; 137(9):1208-1218. Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman E, Indik JH, Shi G, Christensen J, Gupta G, Hillery C, Kansal MM, Parikh DS, Zhou T, Yuan JX, Kanthi Y, Bronk P, Koren G, Kittles R, Duarte JD, Garcia JGN, Machado RF, Dudley SC, Choi BR, Desai AA. PMID: 33181835; PMCID: PMC7933768.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    39. mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target. Int J Mol Sci. 2021 Feb 21; 22(4). Babicheva A, Makino A, Yuan JX. PMID: 33670032; PMCID: PMC7926633.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    40. Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension. J Am Heart Assoc. 2020 12 15; 9(24):e018327. Si R, Zhang Q, Cabrera JTO, Zheng Q, Tsuji-Hosokawa A, Watanabe M, Hosokawa S, Xiong M, Jain PP, Ashton AW, Yuan JX, Wang J, Makino A. PMID: 33307937; PMCID: PMC7955394.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020968531. Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. PMID: 33343881; PMCID: PMC7727059.
      View in: PubMed   Mentions: 4  
    42. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv. 2020 Dec 04. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33300001; PMCID: PMC7724674.
      View in: PubMed   Mentions: 4  
    43. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020956592. Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. PMID: 33282184; PMCID: PMC7691930.
      View in: PubMed   Mentions: 8  
    44. Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox Biol. 2021 01; 38:101785. Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 33221570; PMCID: PMC7691184.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery. Pulm Pharmacol Ther. 2020 10; 64:101975. Gomez AI, Acosta MF, Muralidharan P, Yuan JX, Black SM, Hayes D, Mansour HM. PMID: 33137515; PMCID: PMC8923534.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    46. Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172. Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718; PMCID: PMC7834011.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    47. Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension. Hypertension. 2020 11; 76(5):1589-1599. Zhang C, Zhang T, Lu W, Duan X, Luo X, Liu S, Chen Y, Li Y, Chen J, Liao J, Zhou D, Chen X, Feng H, Gu G, Wang T, Tang H, Makino A, Zhong N, Yuan JX, Yang K, Wang J. PMID: 32921193.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
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