Jason Yuan

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Peking Union Medical College, Beijing, ChinaPhD05/1993Cardiovascular Physiology
    Suzhou Medical College, Suzhou, ChinaMD07/1983
    Collapse Awards and Honors
    The Francis Families Foundation1994  - 1997Parker B. Francis Fellowship
    The American Physiological Society1995Giles F. Filley Memorial Award
    American Heart Association1995Cournand and Comroe Young Investigator Award (Winner)
    American Heart Association1996Best Abstract Award
    American Heart Association1998  - 2003Established Investigator Award
    American Heart Association2003Fellow
    American Society for Clinical Investigation2007Elected Member
    American Association for the Advancement of Science2007Fellow
    John Simon Guggenheim Memorial Foundation2008Guggenheim Fellowship Award
    American Thoracic Society2011Estelle Grover Lecturer
    Pulmonary Vascular Research Institute2012PVRI Achievement Award
    Association of American Physicians2013Elected Member
    American Heart Association2017Kenneth D. Bloch Memorial Lecturer
    The American Physiological Society2018Robert M. Berne Distinguished Lectureship
    American Thoracic Society2019Leadership Award
    The American Physiological Society2019Fellow (FAPS)

    Collapse Research 
    Collapse Research Activities and Funding
    Ion Channels and Membrane Receptors in Pulmonary Arterial Hypertension
    NIH R35HL135807Jan 15, 2017 - Dec 31, 2023
    Role: Principal Investigator
    Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertension
    NIH U01HL125208Sep 15, 2014 - Jul 31, 2020
    Role: Co-Principal Investigator
    Molecular mechanisms of downregulated Kv channels in IPAH: Role of microRNA
    NIH R01HL115014Sep 1, 2012 - May 31, 2017
    Role: Principal Investigator
    2008 Grover Conference on Pulmonary Vascular Pathobiology
    NIH R13HL092781Sep 10, 2008 - Sep 14, 2008
    Role: Principal Investigator
    SNPs in Idopathic Pulmonary Artierial Hypertension
    NIH R21HL080033May 10, 2005 - Apr 30, 2008
    Role: Principal Investigator
    Training in Mechanisms of Cardiovascular Diseases
    NIH T32HL072742Aug 1, 2003 - Jul 31, 2015
    Role: Principal Investigator
    Calcium Signaling in Pulmonary Arterial Hypertension: Role of CaSR and TRPC6
    NIH R01HL066012Dec 1, 2000 - May 31, 2017
    Role: Principal Investigator
    Cellular Mechanisms of PPH: Role of K+ Channels
    NIH R01HL064945Jul 15, 1999 - Jun 30, 2008
    Role: Principal Investigator
    Ion Channels and Pulmonary Vascular Tone
    NIH R01HL054043Apr 1, 1995 - Jun 30, 2010
    Role: Principal Investigator
    ION CHANNELS AND PULMONARY VASCULAR TONE
    NIH R29HL054043Apr 1, 1995 - Mar 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype. Sleep. 2022 06 13; 45(6). Zhen X, Moya EA, Gautane M, Zhao H, Lawrence ES, Gu W, Barnes LA, Yuan JX, Jain PP, Xiong M, Catalan Serra P, Pham LV, Malhotra A, Simonson TS, Mesarwi OA. PMID: 34893914; PMCID: PMC9189937.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. NEDD9 provides mechanistic insight into the coagulopathy of COVID-19. Pulm Circ. 2022 Apr; 12(2):e12087. Rizzo AN, Yuan JX. PMID: 35599982; PMCID: PMC9111000.
      View in: PubMed   Mentions:
    3. Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability. Antioxidants (Basel). 2022 May 05; 11(5). Liu Z, Zhang Y, Youn JY, Zhang Y, Makino A, Yuan JX, Cai H. PMID: 35624768; PMCID: PMC9137638.
      View in: PubMed   Mentions:
    4. JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension. Sci Transl Med. 2022 05 04; 14(643):eabl5471. Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, Yuan JX, Shyy J, Thistlethwaite PA. PMID: 35507674.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Targeting ATP-Sensitive K+ Channels to Treat Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2022 05; 66(5):476-478. Breen E, Yuan JX. PMID: 35238728; PMCID: PMC9116352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex. Transl Res. 2022 09; 247:1-18. Rafikov R, Rischard F, Vasilyev M, Varghese MV, Yuan JX, Desai AA, Garcia JGN, Rafikova O. PMID: 35405322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia. Hum Mol Genet. 2022 03 31; 31(7):1130-1140. Stobdan T, Jain PP, Xiong M, Bafna V, Yuan JX, Haddad GG. PMID: 34718575; PMCID: PMC8976430.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2022 05 01; 322(5):L737-L760. Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 35318857; PMCID: PMC9076422.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 04 11; 57(7):839-853.e6. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. PMID: 35303432; PMCID: PMC9137452.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. In Vivo and Ex Vivo Experimental Approach for Studying Functional Role of Notch in Pulmonary Vascular Disease. Methods Mol Biol. 2022; 2472:209-220. Jain PP, Hosokawa S, Babicheva A, Zhao T, Chen J, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35674903.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial. Lancet Respir Med. 2022 03; 10(3):267-277. Sutharsan S, McKone EF, Downey DG, Duckers J, MacGregor G, Tullis E, Van Braeckel E, Wainwright CE, Watson D, Ahluwalia N, Bruinsma BG, Harris C, Lam AP, Lou Y, Moskowitz SM, Tian S, Yuan J, Waltz D, Mall MA, VX18-445-109 study group. PMID: 34942085.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    12. Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood. Nat Commun. 2021 12 07; 12(1):7104. Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX, An TS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Gräf S, Morrell NW, Wilkins MR, Lawrie A, Wang D, UK National PAH Cohort Study Consortium. PMID: 34876579; PMCID: PMC8651638.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist. Br J Pharmacol. 2022 03; 179(5):1065-1081. Zheng Q, Lu W, Yan H, Duan X, Chen Y, Zhang C, Luo X, Chen J, Wang C, Liu S, Li Y, Tang H, Rahimi S, Rahimi S, Yuan JX, Zhong N, Yang K, Wang J. PMID: 34599843.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211059712. Ahmed M, Zaghloul N, Zimmerman P, Casanova NG, Sun X, Song JH, Hernon VR, Sammani S, Rischard F, Rafikova O, Rafikov R, Makino A, Kempf CL, Camp SM, Wang J, Desai AA, Lussier Y, Yuan JX, Garcia JGN. PMID: 34790349; PMCID: PMC8591779.
      View in: PubMed   Mentions: 3  
    15. HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes. JCI Insight. 2021 11 08; 6(21). Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A. PMID: 34747371; PMCID: PMC8663561.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. TRPC6, a therapeutic target for pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1161-L1182. Jain PP, Lai N, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34704831; PMCID: PMC8715021.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C1010-C1027. Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 34669509; PMCID: PMC8714987.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211041512. Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 34531976; PMCID: PMC8438952.
      View in: PubMed   Mentions: 3  
    19. Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells. Front Physiol. 2021; 12:714785. Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, Lai N, Zhao T, Hernandez M, Balistrieri A, Parmisano S, Simonson T, Breen E, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34408668; PMCID: PMC8364962.
      View in: PubMed   Mentions: 1  
    20. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 09; 178(17):3373-3394. Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-Endothelial Cell Interaction in Pulmonary Hypertension. Am J Respir Crit Care Med. 2021 06 15; 203(12):1455-1458. Wang J, Yang K, Yuan JX. PMID: 33770456; PMCID: PMC8483222.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients. Hypertension. 2021 06; 77(6):1974-1989. Liao J, Lu W, Chen Y, Duan X, Zhang C, Luo X, Lin Z, Chen J, Liu S, Yan H, Chen Y, Feng H, Zhou D, Chen X, Zhang Z, Yang Q, Liu X, Tang H, Li J, Makino A, Yuan JX, Zhong N, Yang K, Wang J. PMID: 33813851.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021 04 30; 128(9):1323-1326. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33784827; PMCID: PMC8091897.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    24. Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy. Antioxidants (Basel). 2021 Mar 11; 10(3). Muralidharan P, Acosta MF, Gomez AI, Grijalva C, Tang H, Yuan JX, Mansour HM. PMID: 33799587; PMCID: PMC7998162.
      View in: PubMed   Mentions: 2  
    25. IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. Blood. 2021 03 04; 137(9):1208-1218. Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman E, Indik JH, Shi G, Christensen J, Gupta G, Hillery C, Kansal MM, Parikh DS, Zhou T, Yuan JX, Kanthi Y, Bronk P, Koren G, Kittles R, Duarte JD, Garcia JGN, Machado RF, Dudley SC, Choi BR, Desai AA. PMID: 33181835; PMCID: PMC7933768.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    26. mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target. Int J Mol Sci. 2021 Feb 21; 22(4). Babicheva A, Makino A, Yuan JX. PMID: 33670032; PMCID: PMC7926633.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension. J Am Heart Assoc. 2020 12 15; 9(24):e018327. Si R, Zhang Q, Cabrera JTO, Zheng Q, Tsuji-Hosokawa A, Watanabe M, Hosokawa S, Xiong M, Jain PP, Ashton AW, Yuan JX, Wang J, Makino A. PMID: 33307937; PMCID: PMC7955394.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    28. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020968531. Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. PMID: 33343881; PMCID: PMC7727059.
      View in: PubMed   Mentions: 2  
    29. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv. 2020 Dec 04. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33300001; PMCID: PMC7724674.
      View in: PubMed   Mentions: 3  
    30. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020956592. Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. PMID: 33282184; PMCID: PMC7691930.
      View in: PubMed   Mentions: 4  
    31. Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox Biol. 2021 01; 38:101785. Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 33221570; PMCID: PMC7691184.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery. Pulm Pharmacol Ther. 2020 10; 64:101975. Gomez AI, Acosta MF, Muralidharan P, Yuan JX, Black SM, Hayes D, Mansour HM. PMID: 33137515; PMCID: PMC8923534.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172. Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718; PMCID: PMC7834011.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    34. Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension. Hypertension. 2020 11; 76(5):1589-1599. Zhang C, Zhang T, Lu W, Duan X, Luo X, Liu S, Chen Y, Li Y, Chen J, Liao J, Zhou D, Chen X, Feng H, Gu G, Wang T, Tang H, Makino A, Zhong N, Yuan JX, Yang K, Wang J. PMID: 32921193.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep; 10(3):2045894020948470. Wu K, Tang H, Lin R, Carr SG, Wang Z, Babicheva A, Ayon RJ, Jain PP, Xiong M, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Valdez-Jasso D, Simonson TS, Desai AA, Garcia JGN, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 33294172; PMCID: PMC7707860.
      View in: PubMed   Mentions: 4  
    36. Hypoxia-induced pulmonary hypertension-Utilizing experiments of nature. Br J Pharmacol. 2021 01; 178(1):121-131. Gassmann M, Cowburn A, Gu H, Li J, Rodriguez M, Babicheva A, Jain PP, Xiong M, Gassmann NN, Yuan JX, Wilkins MR, Zhao L. PMID: 32464698.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    37. MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. 2020 09 22; 142(12):1190-1204. Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, Lei Y, Chen S, Yin Q, Thistlethwaite PA, Wang J, Gong K, Yuan ZY, Yuan JX, Shyy JY. PMID: 32755395; PMCID: PMC7497891.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    38. Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α. Am J Respir Cell Mol Biol. 2020 07; 63(1):92-103. Sun X, Sun BL, Babicheva A, Vanderpool R, Oita RC, Casanova N, Tang H, Gupta A, Lynn H, Gupta G, Rischard F, Sammani S, Kempf CL, Moreno-Vinasco L, Ahmed M, Camp SM, Wang J, Desai AA, Yuan JX, Garcia JGN. PMID: 32142369; PMCID: PMC7328254.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    39. Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 06 01; 201(11):1407-1415. Karnes JH, Wiener HW, Schwantes-An TH, Natarajan B, Sweatt AJ, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JX, Kittles R, de Jesus Perez V, Zamanian RT, Rischard F, Tiwari HK, Nichols WC, Benza RL, Desai AA. PMID: 31916850; PMCID: PMC7258627.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling? Am J Respir Crit Care Med. 2020 05 15; 201(10):1177-1179. Goncharova EA, Simon MA, Yuan JX. PMID: 31968178; PMCID: PMC7233339.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    41. Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes. Cardiovasc Res. 2020 05 01; 116(6):1186-1198. Si R, Zhang Q, Tsuji-Hosokawa A, Watanabe M, Willson C, Lai N, Wang J, Dai A, Scott BT, Dillmann WH, Yuan JX, Makino A. PMID: 31504245; PMCID: PMC7177511.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension. Br J Pharmacol. 2020 06; 177(12):2743-2764. Chen Y, Lu W, Yang K, Duan X, Li M, Chen X, Zhang J, Kuang M, Liu S, Wu X, Zou G, Liu C, Hong C, He W, Liao J, Hou C, Zhang Z, Zheng Q, Chen J, Zhang N, Tang H, Vanderpool RR, Desai AA, Rischard F, Black SM, Garcia JGN, Makino A, Yuan JX, Zhong N, Wang J. PMID: 31976548; PMCID: PMC7236078.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    43. Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels. Am J Physiol Cell Physiol. 2020 05 01; 318(5):C954-C968. Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX. PMID: 32186932; PMCID: PMC7294324.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    44. Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis. J Heart Lung Transplant. 2020 04; 39(4):310-320. Badagliacca R, Rischard F, Papa S, Kubba S, Vanderpool R, Yuan JX, Garcia JGN, Airhart S, Poscia R, Pezzuto B, Manzi G, Miotti C, Luongo F, Scoccia G, Sciomer S, Torre R, Fedele F, Vizza CD. PMID: 32061507.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. Br J Pharmacol. 2020 01; 177(2):314-327. Zhang Q, Tsuji-Hosokawa A, Willson C, Watanabe M, Si R, Lai N, Wang Z, Yuan JX, Wang J, Makino A. PMID: 31503328; PMCID: PMC6989957.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    46. Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition. Am J Respir Cell Mol Biol. 2020 01; 62(1):49-60. Huang J, Lu W, Ouyang H, Chen Y, Zhang C, Luo X, Li M, Shu J, Zheng Q, Chen H, Chen J, Tang H, Sun D, Yuan JX, Yang K, Wang J. PMID: 31211918; PMCID: PMC6938136.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L10-L26. Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX. PMID: 31553627; PMCID: PMC6985878.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    48. KCNK3 Channel: A New Player in the Field of Pulmonary Vascular Disease. Circ Res. 2019 09 13; 125(7):696-698. Babicheva A, Zhao T, Yuan JX. PMID: 31513487.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    49. PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13394-13403. Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L, Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y. PMID: 31213542; PMCID: PMC6613097.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    50. EXPRESS: Surfing the Right Ventricular Pressure Waveform: Methods to assess Global, Systolic and Diastolic RV Function from a Clinical Right Heart Catheterization. Pulm Circ. 2019 Apr 29; 2045894019850993. Vanderpool RR, Puri R, Osorio A, Wickstrom K, Desai A, Black S, Garcia JGN, Yuan J, Rischard F. PMID: 31032737; PMCID: PMC7031797.
      View in: PubMed   Mentions: 6  
    51. Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension. Antioxid Redox Signal. 2019 11 01; 31(13):917-932. Rafikov R, Nair V, Sinari S, Babu H, Sullivan JC, Yuan JX, Desai AA, Rafikova O. PMID: 30652485; PMCID: PMC6765065.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    52. Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. Antioxid Redox Signal. 2019 10 20; 31(12):819-842. Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 30623676; PMCID: PMC6751394.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    53. Endothelial Notch1 in Pulmonary Hypertension. Circ Res. 2019 01 18; 124(2):176-179. Babicheva A, Yuan JX. PMID: 30653427; PMCID: PMC6368966.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    54. Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. JACC Basic Transl Sci. 2018 Dec; 3(6):744-762. Tang H, Wu K, Wang J, Vinjamuri S, Gu Y, Song S, Wang Z, Zhang Q, Balistrieri A, Ayon RJ, Rischard F, Vanderpool R, Chen J, Zhou G, Desai AA, Black SM, Garcia JGN, Yuan JX, Makino A. PMID: 30623134; PMCID: PMC6314964.
      View in: PubMed   Mentions: 24  
    55. Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase. mBio. 2018 12 18; 9(6). Sutherland MC, Tran NL, Tillman DE, Jarodsky JM, Yuan J, Kranz RG. PMID: 30563894; PMCID: PMC6299221.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    56. Pathophysiology of stroke: what do cells of the neurovascular unit have to do with it? Am J Physiol Cell Physiol. 2019 01 01; 316(1):C1. O'Donnell ME, Yuan JX. PMID: 30462541.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    57. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L216-L228. Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, Jiang Q, Li M, Chen Y, Carr SG, Wu K, Zhang Q, Balistrieri A, Wang C, Song S, Ayon RJ, Desai AA, Black SM, Garcia JGN, Makino A, Yuan JX, Lu W, Wang J. PMID: 30358436; PMCID: PMC6383500.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca2+ Channels. Biomed Res Int. 2018; 2018:4892349. Miao R, Wan J, Liu J, Yuan JX, Wang J, Xie W, Zhai Z, Wang C. PMID: 30320134; PMCID: PMC6167576.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    59. New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension. PLoS One. 2018; 13(8):e0203493. Kurdyukov S, Eccles CA, Desai AA, Gonzalez-Garay M, Yuan JX, Garcia JGN, Rafikova O, Rafikov R. PMID: 30161219; PMCID: PMC6117081.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    60. Pathophysiology of stroke: the many and varied contributions of brain microvasculature. Am J Physiol Cell Physiol. 2018 09 01; 315(3):C341-C342. O'Donnell ME, Yuan JX. PMID: 30110563; PMCID: PMC6171040.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    61. Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension. Cell Signal. 2018 11; 51:119-129. Dai J, Zhou Q, Tang H, Chen T, Li J, Raychaudhuri P, Yuan JX, Zhou G. PMID: 30092353; PMCID: PMC6119636.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    62. LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18. Am J Respir Cell Mol Biol. 2018 05; 58(5):614-624. Gross CM, Kellner M, Wang T, Lu Q, Sun X, Zemskov EA, Noonepalle S, Kangath A, Kumar S, Gonzalez-Garay M, Desai AA, Aggarwal S, Gorshkov B, Klinger C, Verin AD, Catravas JD, Jacobson JR, Yuan JX, Rafikov R, Garcia JGN, Black SM. PMID: 29115856; PMCID: PMC5946326.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    63. STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension. Hypertension. 2018 03; 71(3):518-529. Song S, Carr SG, McDermott KM, Rodriguez M, Babicheva A, Balistrieri A, Ayon RJ, Wang J, Makino A, Yuan JX. PMID: 29358461; PMCID: PMC5955710.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    64. Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C504-C517. He X, Song S, Ayon RJ, Balisterieri A, Black SM, Makino A, Wier WG, Zang WJ, Yuan JX. PMID: 29351410; PMCID: PMC5966788.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    65. Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217752912. Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ. PMID: 29283043; PMCID: PMC5798691.
      View in: PubMed   Mentions: 54  
    66. AJP-Cell Physiology begins landmark reviews in cell physiology: an editorial from the senior editors of AJP-Cell Physiology. Am J Physiol Cell Physiol. 2018 01 01; 314(1):C1-C2. Delpire E, Hamilton KL, Hawke TJ, Isenberg JS, Lotersztajn S, Yuan JX, Adams JC. PMID: 29092820; PMCID: PMC6334934.
      View in: PubMed   Mentions:    Fields:    
    67. Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension? Am J Respir Cell Mol Biol. 2017 11; 57(5):506-508. Vanderpool RR, Tang H, Rischard F, Yuan JX. PMID: 29090954; PMCID: PMC5705908.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    68. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ Res. 2017 10 27; 121(10):1136-1139. Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA, PVDOMICS Study Group. PMID: 29074534; PMCID: PMC5685561.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCTClinical Trials
    69. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2018 02 01; 314(2):L256-L275. Tang H, Babicheva A, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX. PMID: 29074488; PMCID: PMC5866501.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    70. Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol. 2017 Nov; 174(22):4155-4172. Wu K, Zhang Q, Wu X, Lu W, Tang H, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z, McDermott KM, Balistrieri A, Wang C, Black SM, Garcia JGN, Makino A, Yuan JX, Wang J. PMID: 28849593; PMCID: PMC5659991.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    71. How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension. Eur Respir J. 2017 08; 50(2). Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP. PMID: 28838981; PMCID: PMC6330704.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension. Pulm Circ. 2017 Jul-Sep; 7(3):569-571. Tang H, Vanderpool RR, Wang J, Yuan JX. PMID: 28895506; PMCID: PMC5841892.
      View in: PubMed   Mentions: 1  
    73. The Pulmonary Vascular Research Institute celebrates its first decade. Pulm Circ. 2017 Apr-Jun; 7(2):283-284. Yuan JX, Morrell NW, Stenmark KR, Lang IM, Butrous G, Reynolds ME. PMID: 28597776; PMCID: PMC5467951.
      View in: PubMed   Mentions:
    74. Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension. Circulation. 2017 04 18; 135(16):1532-1546. Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JGN, Machado RF. PMID: 28202489; PMCID: PMC5400780.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    75. Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets. Am J Physiol Lung Cell Mol Physiol. 2017 04 01; 312(4):L452-L476. Wang T, Gross C, Desai AA, Zemskov E, Wu X, Garcia AN, Jacobson JR, Yuan JX, Garcia JG, Black SM. PMID: 27979857; PMCID: PMC5407098.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    76. Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol. 2017 03 01; 312(3):L309-L325. Song S, Ayon RJ, Yamamura A, Yamamura H, Dash S, Babicheva A, Tang H, Sun X, Cordery AG, Khalpey Z, Black SM, Desai AA, Rischard F, McDermott KM, Garcia JG, Makino A, Yuan JX. PMID: 27979859; PMCID: PMC5374303.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    77. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016 12 05; 5(12). Chen T, Zhou Q, Tang H, Bozkanat M, Yuan JX, Raj JU, Zhou G. PMID: 27919930; PMCID: PMC5210422.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    78. Our readership grows by leaps and bounds. Pulm Circ. 2016 Dec; 6(4):405-406. Yuan JX, Morrell NW, Stenmark KR, Butrous G, Reynolds ME. PMID: 28090284; PMCID: PMC5210069.
      View in: PubMed   Mentions:
    79. Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series). Pulm Circ. 2016 Dec; 6(4):448-464. Pullamsetti SS, Perros F, Chelladurai P, Yuan J, Stenmark K. PMID: 28090287; PMCID: PMC5210074.
      View in: PubMed   Mentions: 24  
    80. Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. Free Radic Biol Med. 2017 01; 102:217-228. Kumar S, Sun X, Noonepalle SK, Lu Q, Zemskov E, Wang T, Aggarwal S, Gross C, Sharma S, Desai AA, Hou Y, Dasarathy S, Qu N, Reddy V, Lee SG, Cherian-Shaw M, Yuan JX, Catravas JD, Rafikov R, Garcia JGN, Black SM. PMID: 27838434; PMCID: PMC5449193.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    81. Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. Front Physiol. 2016; 7:517. Smith KA, Ayon RJ, Tang H, Makino A, Yuan JX. PMID: 27867361; PMCID: PMC5095111.
      View in: PubMed   Mentions: 30  
    82. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 10 01; 311(4):H944-H957. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. PMID: 27591215; PMCID: PMC5114466.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    83. Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms. Am J Respir Crit Care Med. 2016 08 15; 194(4):393-7. Tang H, Desai AA, Yuan JX. PMID: 27525458; PMCID: PMC5003333.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    84. Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol. 2016 08; 55(2):275-87. Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM. PMID: 26959555; PMCID: PMC4979361.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    85. Ryanodine receptor-2: a necessity for gating store-operated Ca2+ channels. Cardiovasc Res. 2016 07 01; 111(1):13-5. Song S, Ayon RJ, Yuan JX. PMID: 27229459.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    86. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 07 01; 311(1):C136-49. Jiang Q, Lu W, Yang K, Hadadi C, Fu X, Chen Y, Yun X, Zhang J, Li M, Xu L, Tang H, Yuan JX, Wang J, Sun D. PMID: 27194472; PMCID: PMC4967135.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    87. Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L846-59. Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg DR, Chen J, Gu Y, Pohl NM, Zhou T, Jiménez-Pérez L, Ayon RJ, Desai AA, Goltzman D, Rischard F, Khalpey Z, Black SM, Garcia JG, Makino A, Yuan JX. PMID: 26968768; PMCID: PMC4867349.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    88. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One. 2016; 11(3):e0150480. Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM. PMID: 26937637; PMCID: PMC4777490.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    89. Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. Free Radic Biol Med. 2016 06; 95:96-111. Rafikova O, Rafikov R, Kangath A, Qu N, Aggarwal S, Sharma S, Desai J, Fields T, Ludewig B, Yuan JX, Jonigk D, Black SM. PMID: 26928584; PMCID: PMC5929487.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    90. Gasping for answers. Focus on "Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia". Am J Physiol Cell Physiol. 2016 Mar 15; 310(6):C432-3. Ayon RJ, Tang H, Yuan JX. PMID: 26843530; PMCID: PMC4796283.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    91. ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol. 2016 Jan 15; 310(2):C99-114. Song S, Jacobson KN, McDermott KM, Reddy SP, Cress AE, Tang H, Dudek SM, Black SM, Garcia JG, Makino A, Yuan JX. PMID: 26491047; PMCID: PMC4719033.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    92. SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L1027-36. Han Y, Cho YE, Ayon R, Guo R, Youssef KD, Pan M, Dai A, Yuan JX, Makino A. PMID: 26361875; PMCID: PMC4628985.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    93. Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. PMID: 25569851; PMCID: PMC4566064.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    94. Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Redox Biol. 2015 Dec; 6:278-286. Rafikov R, Sun X, Rafikova O, Louise Meadows M, Desai AA, Khalpey Z, Yuan JX, Fineman JR, Black SM. PMID: 26298201; PMCID: PMC4556771.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    95. MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on "miR-223 reverses experimental pulmonary arterial hypertension". Am J Physiol Cell Physiol. 2015 Sep 15; 309(6):C361-2. Smith KA, Yuan JX, Schumacker PT. PMID: 26201953.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    96. Response to Letter Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". Circulation. 2015 Jul 14; 132(2):e17. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. PMID: 26169652; PMCID: PMC4624330.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    97. New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis. EMBO Mol Med. 2015 Jun; 7(6):689-91. Tang H, Ayon RJ, Yuan JX. PMID: 25851536; PMCID: PMC4459811.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    98. Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015 Mar 15; 191(6):678-92. Chen T, Zhou G, Zhou Q, Tang H, Ibe JC, Cheng H, Gou D, Chen J, Yuan JX, Raj JU. PMID: 25647182; PMCID: PMC4384776.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    99. The rise and rise of Pulmonary Circulation. Pulm Circ. 2015 Mar; 5(1):1-2. Yuan JX, Morrell NW, Westcott A, Butrous G. PMID: 25992266; PMCID: PMC4405727.
      View in: PubMed   Mentions:
    100. Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. Am J Physiol Cell Physiol. 2015 Apr 15; 308(8):C581-93. Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX. PMID: 25673771; PMCID: PMC4398853.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    101. miRNA208/Mef2 and TNF-α in right ventricular dysfunction: the transition from hypertrophy to failure. Circ Res. 2015 Jan 02; 116(1):6-8. Tang H, Fernandez RA, Yuan JX. PMID: 25552686; PMCID: PMC4890563.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    102. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15; 308(2):L208-20. Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. PMID: 25416384; PMCID: PMC4338938.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    103. The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 Nov 01; 190(9):1032-43. Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. PMID: 25180446; PMCID: PMC4299585.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    104. ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease. Circulation. 2014 Sep 30; 130(14):1179-91. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. PMID: 25062690; PMCID: PMC4182129.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    105. Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension. PLoS One. 2014; 9(6):e101055. Guo L, Yang Y, Liu J, Wang L, Li J, Wang Y, Liu Y, Gu S, Gan H, Cai J, Yuan JX, Wang J, Wang C. PMID: 24978044; PMCID: PMC4076206.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    106. Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Aug 15; 307(4):C373-83. Song S, Yamamura A, Yamamura H, Ayon RJ, Smith KA, Tang H, Makino A, Yuan JX. PMID: 24920677; PMCID: PMC4137136.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    107. [Effects of gender on severity and pulmonary artery vascular reactivity in chronic hypoxic pulmonary hypertension in mice]. Zhonghua Yi Xue Za Zhi. 2014 Jun 10; 94(22):1692-5. Wan J, Yuan JX, Miao R, Zhai Z, Zhang M, Yang Y, Wang J, Wang C. PMID: 25151896.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    108. Breaking barriers in obstructive sleep apnea. Focus on "Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation". Am J Physiol Cell Physiol. 2014 Apr 15; 306(8):C724-5. Smith KA, Yuan JX. PMID: 24627556.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    109. Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One. 2014; 9(3):e90544. Zimnicka AM, Tang H, Guo Q, Kuhr FK, Oh MJ, Wan J, Chen J, Smith KA, Fraidenburg DR, Choudhury MS, Levitan I, Machado RF, Kaplan JH, Yuan JX. PMID: 24614111; PMCID: PMC3948681.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    110. The voice of pulmonary circulation. Pulm Circ. 2014 Mar; 4(1):1. Yuan JX, Morrell NW, Holt C, Butrous G. PMID: 25006415; PMCID: PMC4070763.
      View in: PubMed   Mentions:
    111. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C871-8. Yamamura H, Yamamura A, Ko EA, Pohl NM, Smith KA, Zeifman A, Powell FL, Thistlethwaite PA, Yuan JX. PMID: 24573085; PMCID: PMC4010807.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    112. Hypoxia-inducible factor-1α in pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):245-6. Smith KA, Yuan JX. PMID: 24484328; PMCID: PMC3977736.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    113. Deacetylation of MicroRNA-124 in fibroblasts: role in pulmonary hypertension. Circ Res. 2014 Jan 03; 114(1):5-8. Pohl NM, Fernandez RA, Smith KA, Yuan JX. PMID: 24385500.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    114. MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension. Pulm Circ. 2013 Sep; 3(3):654-64. Wang L, Guo LJ, Liu J, Wang W, Yuan JX, Zhao L, Wang J, Wang C. PMID: 24618550; PMCID: PMC4070804.
      View in: PubMed   Mentions: 17  
    115. Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension. Physiol Rep. 2013 Dec 01; 1(7):e00190. Ogawa A, Firth AL, Ariyasu S, Yamadori I, Matsubara H, Song S, Fraidenburg DR, Yuan JX. PMID: 24744867; PMCID: PMC3970741.
      View in: PubMed   Mentions: 12     Fields:    
    116. Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice. Hypertens Res. 2014 Feb; 37(2):116-24. Guo Q, Huang JA, Yamamura A, Yamamura H, Zimnicka AM, Fernandez R, Yuan JX. PMID: 24089267; PMCID: PMC5524516.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    117. Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):609-18. Ibe JC, Zhou Q, Chen T, Tang H, Yuan JX, Raj JU, Zhou G. PMID: 23668615; PMCID: PMC3824043.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    118. Mutant hERG channel traffic jam. Focus on "Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum". Am J Physiol Cell Physiol. 2013 Nov 01; 305(9):C916-8. Ayon RJ, Fernandez RA, Yuan JX. PMID: 23986200.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    119. Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model. PLoS One. 2013; 8(8):e70176. Chen J, Feng G, Guo Q, Wardenburg JB, Lin S, Inoshima I, Deaton R, Yuan JX, Garcia JG, Machado RF, Otto M, Wunderink RG. PMID: 23936388; PMCID: PMC3731344.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    120. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. PMID: 23713908; PMCID: PMC3778734.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    121. Current and future therapeutic targets for pulmonary arterial hypertension. High Alt Med Biol. 2013 Jun; 14(2):134-43. Fraidenburg D, Yuan J. PMID: 23795733.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    122. Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15; 305(2):L154-64. Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. PMID: 23686856; PMCID: PMC3726947.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    123. Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension. Circ Res. 2013 Apr 12; 112(8):1091-3. Fraidenburg DR, Yuan JX. PMID: 23580770; PMCID: PMC3728159.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    124. Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction. Pulm Circ. 2013 Apr; 3(2):396-405. Yoo HY, Zeifman A, Ko EA, Smith KA, Chen J, Machado RF, Zhao YY, Minshall RD, Yuan JX. PMID: 24015341; PMCID: PMC3757835.
      View in: PubMed   Mentions: 13  
    125. Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol. 2013 Jun 01; 304(11):C1042-52. Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. PMID: 23426966; PMCID: PMC3677177.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    126. Human models for smooth muscle cell differentiation. Focus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells". Am J Physiol Cell Physiol. 2013 Feb 15; 304(4):C287-8. Firth AL, Yuan JX. PMID: 23325406.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    127. Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells. Circ Res. 2013 Feb 15; 112(4):640-50. Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wan J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX. PMID: 23300272; PMCID: PMC3642037.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    128. Readership: The heart of Pulmonary Circulation. Pulm Circ. 2013 Jan; 3(1):1-2. Yuan JX, Morrell NW, Holt C, Butrous G. PMID: 23662169; PMCID: PMC3641711.
      View in: PubMed   Mentions:
    129. [Enhanced Ca2+-sensing receptor function in pulmonary hypertension]. Yakugaku Zasshi. 2013; 133(12):1351-9. Yamamura A, Yamamura H, Yuan JX. PMID: 24292183.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    130. Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension. J Signal Transduct. 2012; 2012:951497. Fernandez RA, Sundivakkam P, Smith KA, Zeifman AS, Drennan AR, Yuan JX. PMID: 23056939; PMCID: PMC3465915.
      View in: PubMed   Mentions: 8  
    131. H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on "Endogenous H2S is required for hypoxic sensing by carotid body glomus cells". Am J Physiol Cell Physiol. 2012 Nov 01; 303(9):C911-2. Smith KA, Yuan JX. PMID: 22992680.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    132. STIM1 restores coronary endothelial function in type 1 diabetic mice. Circ Res. 2012 Oct 12; 111(9):1166-75. Estrada IA, Donthamsetty R, Debski P, Zhou MH, Zhang SL, Yuan JX, Han W, Makino A. PMID: 22896585; PMCID: PMC3627729.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    133. Are men at risk? The role of testosterone in cardiovascular morbidity. Pulm Circ. 2012 Jul; 2(3):275-7. Sundivakkam PC, Desai AA, Smith KA, Yuan JX. PMID: 23130097; PMCID: PMC3487297.
      View in: PubMed   Mentions:
    134. CRACing the cluster: functionally active Orai1 channels in the absence of clustering with STIM1. Circ Res. 2012 Jun 22; 111(1):9-11. Smith KA, Yuan JX. PMID: 22723218; PMCID: PMC3387275.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    135. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012 Aug 03; 111(4):469-81. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX. PMID: 22730443; PMCID: PMC3695473.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    136. Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J. 2013 Feb; 41(2):462-8. Lang IM, Pesavento R, Bonderman D, Yuan JX. PMID: 22700839.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    137. A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med. 2012 Aug 15; 186(4):359-68. Desai AA, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, Wade MS, Raghavachari N, Kato GJ, Peters-Lawrence MH, Thiruvoipati T, Turner K, Artz N, Huang Y, Patel AR, Yuan JX, Gordeuk VR, Lang RM, Garcia JG, Machado RF. PMID: 22679008; PMCID: PMC3443809.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    138. Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. Am J Pathol. 2012 Jun; 180(6):2268-75. Zhao YD, Cai L, Mirza MK, Huang X, Geenen DL, Hofmann F, Yuan JX, Zhao YY. PMID: 22632818; PMCID: PMC3717780.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    139. "Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cells. Focus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel". Am J Physiol Cell Physiol. 2012 Jul 15; 303(2):C113-4. Firth AL, Yuan JX. PMID: 22572851.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    140. Science is an endless frontier: Encouraging translational research in pulmonary vascular disease. Pulm Circ. 2012 Apr-Jun; 2(2):137-8. Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22837853; PMCID: PMC3401866.
      View in: PubMed   Mentions:
    141. Thyroid hormone receptor-α and vascular function. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1346-52. Makino A, Wang H, Scott BT, Yuan JX, Dillmann WH. PMID: 22322976; PMCID: PMC3361953.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    142. New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8):H1546-62. Kuhr FK, Smith KA, Song MY, Levitan I, Yuan JX. PMID: 22245772; PMCID: PMC3330808.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    143. A one-year-old baby… into the Year of the Dragon. Pulm Circ. 2012 Jan-Mar; 2(1):1-2. Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22558513; PMCID: PMC3342737.
      View in: PubMed   Mentions:
    144. Identification of functional progenitor cells in the pulmonary vasculature. Pulm Circ. 2012 Jan-Mar; 2(1):84-100. Firth AL, Yuan JX. PMID: 22558524; PMCID: PMC3342753.
      View in: PubMed   Mentions: 3  
    145. PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C405-11. Ogawa A, Firth AL, Smith KA, Maliakal MV, Yuan JX. PMID: 22031597; PMCID: PMC3328839.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    146. VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury. Biochem Biophys Res Commun. 2011 Oct 07; 413(4):630-6. Guo Q, Jin J, Yuan JX, Zeifman A, Chen J, Shen B, Huang J. PMID: 21939637.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    147. The world of pulmonary vascular disease. Pulm Circ. 2011 Jul-Sep; 1(3):303-4. Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22140619; PMCID: PMC3224421.
      View in: PubMed   Mentions:
    148. Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr Physiol. 2011 Jul; 1(3):1555-602. Makino A, Firth AL, Yuan JX. PMID: 23733654; PMCID: PMC5524522.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    149. Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells. Pulm Circ. 2011 Jul-Sep; 1(3):405-18. Yao W, Mu W, Zeifman A, Lofti M, Remillard CV, Makino A, Perkins DL, Garcia JG, Yuan JX, Zhang W. PMID: 22140631; PMCID: PMC3224433.
      View in: PubMed   Mentions: 2  
    150. American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C253-4. Arcangeli A, Yuan JX. PMID: 21613608.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    151. Tension Measurement in Isolated Rat and Mouse Pulmonary Artery. Drug Discov Today Dis Models. 2010; 7(3-4):123-130. Ko EA, Song MY, Donthamsetty R, Makino A, Yuan JX. PMID: 23175638; PMCID: PMC3501740.
      View in: PubMed   Mentions: 7  
    152. Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts. J Am Coll Cardiol. 2011 May 03; 57(18):1846-55. Tang T, Hammond HK, Firth A, Yang Y, Gao MH, Yuan JX, Lai NC. PMID: 21527160; PMCID: PMC3087976.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    153. Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. Antioxid Redox Signal. 2011 Sep 15; 15(6):1549-65. Song MY, Makino A, Yuan JX. PMID: 21126186; PMCID: PMC3151422.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    154. Our journey continues. Pulm Circ. 2011 Apr-Jun; 1(2):133. Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22034601; PMCID: PMC3198651.
      View in: PubMed   Mentions:
    155. Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells. Pulm Circ. 2011 Apr-Jun; 1(2):269-79. Yamamura A, Yamamura H, Zeifman A, Yuan JX. PMID: 22034612; PMCID: PMC3198647.
      View in: PubMed   Mentions: 23  
    156. STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension. Pulm Circ. 2011; 1(1):84-94. Song MY, Makino A, Yuan JX. PMID: 21709766; PMCID: PMC3121304.
      View in: PubMed   Mentions: 49  
    157. Pulmonary Circulation : A new venue for communicating your findings, ideas and perspectives. Pulm Circ. 2011 Jan-Mar; 1(1):1-2. Yuan JX, Morrell NW, Harikrishnan S, Butrous G. PMID: 22034592; PMCID: PMC3198629.
      View in: PubMed   Mentions: 1  
    158. Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension. Pulm Circ. 2011 Jan-Mar; 1(1):111-4. Kuang T, Wang J, Zeifman A, Pang B, Huang X, Burg ED, Yuan JX, Wang C. PMID: 22034597; PMCID: PMC3198628.
      View in: PubMed   Mentions: 1  
    159. Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels. Pulm Circ. 2011 Jan 01; 1(1):48-71. Firth AL, Remillard CV, Platoshyn O, Fantozzi I, Ko EA, Yuan JX. PMID: 21927714; PMCID: PMC3173772.
      View in: PubMed   Mentions: 33  
    160. Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):349-55. Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK. PMID: 21195051; PMCID: PMC3219303.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    161. Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol. 2011 Mar; 79(3):381-8. Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK. PMID: 21127130; PMCID: PMC3061356.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    162. Pulmonary hypertension in China: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl):69S-77S. Zhai Z, Wang J, Zhao L, Yuan JX, Wang C. PMID: 20522582.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    163. Idiopathic pulmonary arterial hypertension. Dis Model Mech. 2010 May-Jun; 3(5-6):268-73. Firth AL, Mandel J, Yuan JX. PMID: 20427556; PMCID: PMC2860847.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    164. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Cell Physiol. 2010 May; 298(5):C1217-25. Firth AL, Yao W, Ogawa A, Madani MM, Lin GY, Yuan JX. PMID: 20181931; PMCID: PMC2867379.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    165. Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats. Pulm Pharmacol Ther. 2010 Oct; 23(5):456-64. Kuang T, Wang J, Pang B, Huang X, Burg ED, Yuan JX, Wang C. PMID: 20188205; PMCID: PMC3108059.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    166. Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2010 Apr; 298(4):L548-57. Firth AL, Yao W, Remillard CV, Ogawa A, Yuan JX. PMID: 20139178; PMCID: PMC2853339.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    167. Introduction to TRP channels: structure, function, and regulation. Adv Exp Med Biol. 2010; 661:99-108. Song MY, Yuan JX. PMID: 20204725.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    168. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C496-509. Burg ED, Platoshyn O, Tsigelny IF, Lozano-Ruiz B, Rana BK, Yuan JX. PMID: 20018952; PMCID: PMC2838577.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    169. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med. 2009 Nov; 15(11):1289-97. Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW, Thistlethwaite PA. PMID: 19855400; PMCID: PMC2780347.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    170. Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases. Prog Biophys Mol Biol. 2010 Sep; 103(1):95-101. Ko EA, Park WS, Firth AL, Kim N, Yuan JX, Han J. PMID: 19835907.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    171. Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann N Y Acad Sci. 2009 Oct; 1177:101-11. Firth AL, Platoshyn O, Brevnova EE, Burg ED, Powell F, Haddad GH, Yuan JX. PMID: 19845612.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    172. Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L666-76. Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite PA, Yuan JX. PMID: 19633069; PMCID: PMC2770792.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    173. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest. 2009 Jul; 119(7):2009-18. Zhao YY, Zhao YD, Mirza MK, Huang JH, Potula HH, Vogel SM, Brovkovych V, Yuan JX, Wharton J, Malik AB. PMID: 19487814; PMCID: PMC2701851.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    174. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S10-S19. Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M. PMID: 19555853.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansAnimals
    175. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S20-S31. Morrell NW, Adnot S, Archer SL, Dupuis J, Lloyd Jones P, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. PMID: 19555855; PMCID: PMC2790324.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansAnimalsCells
    176. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009 May 05; 119(17):2313-22. Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX. PMID: 19380626; PMCID: PMC2749566.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    177. Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L979-86. Firth AL, Yau J, White A, Chiles PG, Marsh JJ, Morris TA, Yuan JX. PMID: 19363122; PMCID: PMC2692802.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    178. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L870-8. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX. PMID: 19286928; PMCID: PMC2692803.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    179. Bringing down the ROS: a new therapeutic approach for PPHN. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L976-8. Firth AL, Yuan JX. PMID: 18931050; PMCID: PMC2654816.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    180. Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1499-509. Rao JN, Liu SV, Zou T, Liu L, Xiao L, Zhang X, Bellavance E, Yuan JX, Wang JY. PMID: 18923057; PMCID: PMC2603560.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    181. Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1048-55. Sacks RS, Firth AL, Remillard CV, Agange N, Yau J, Ko EA, Yuan JX. PMID: 18836030; PMCID: PMC2604792.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    182. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546; PMCID: PMC2519786.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    183. Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L648-57. Ogawa A, Firth AL, Yao W, Rubin LJ, Yuan JX. PMID: 18708631; PMCID: PMC2575943.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    184. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1529-38. Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX. PMID: 18689502; PMCID: PMC2593496.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    185. Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C221-30. Makino A, Platoshyn O, Suarez J, Yuan JX, Dillmann WH. PMID: 18463230; PMCID: PMC2493564.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    186. Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208. Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JX. PMID: 18432456; PMCID: PMC5524512.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    187. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 01; 117(1):61-9. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. PMID: 18071070.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    188. Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H220-8. Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX. PMID: 17982012.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    189. Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L952-9. Wu W, Platoshyn O, Firth AL, Yuan JX. PMID: 17693484.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    190. Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). Biol Cell. 2007 Aug; 99(8):433-44. Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH. PMID: 17388782.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    191. Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C928-37. Ko EA, Burg ED, Platoshyn O, Msefya J, Firth AL, Yuan JX. PMID: 17581857.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    192. Heterogeneity of hypoxia-mediated decrease in I(K(V)) and increase in [Ca2+](cyt) in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L402-16. Platoshyn O, Yu Y, Ko EA, Remillard CV, Yuan JX. PMID: 17526598.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    193. Point:Counterpoint "Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction". J Appl Physiol (1985). 2007 05; 102(5):2078; discussion 2080. Yuan JX. PMID: 17549820.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    194. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. PMID: 17470567.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    195. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77. Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. PMID: 17381514.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    196. Cardiac L-arginine transport: the CAT is back. J Physiol. 2007 May 01; 580(Pt.3):699-700. Remillard CV, Yuan JX. PMID: 17363379; PMCID: PMC2075442.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    197. TRP channels in hypertension. Biochim Biophys Acta. 2007 Aug; 1772(8):895-906. Firth AL, Remillard CV, Yuan JX. PMID: 17399958; PMCID: PMC2025589.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    198. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007 May; 292(5):C1837-53. Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O'connor DT, Yuan JX. PMID: 17267549.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    199. Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007 Jun; 292(6):C2297-305. Zhang S, Dong H, Rubin LJ, Yuan JX. PMID: 17192285.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    200. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10. Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. PMID: 17189322.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    201. TRP channels, CCE, and the pulmonary vascular smooth muscle. Microcirculation. 2006 Dec; 13(8):671-92. Remillard CV, Yuan JX. PMID: 17085427.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    202. Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels. Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3):L685-98. Schach C, Xu M, Platoshyn O, Keller SH, Yuan JX. PMID: 17098807.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    203. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303. Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. PMID: 16980375.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    204. Transient receptor potential channels and caveolin-1: good friends in tight spaces. Mol Pharmacol. 2006 Oct; 70(4):1151-4. Remillard CV, Yuan JX. PMID: 16873578.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    205. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L993-1004. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. PMID: 16815889.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    206. Molecular biology of chronic thromboembolic pulmonary hypertension. Semin Thorac Cardiovasc Surg. 2006; 18(3):265-76. Sacks RS, Remillard CV, Agange N, Auger WR, Thistlethwaite PA, Yuan JX. PMID: 17185190.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    207. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):192-208. Murray F, Insel PA, Yuan JX. PMID: 16364695.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    208. TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G782-92. Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Marasa BS, Turner DJ, Yuan JX, Wang JY. PMID: 16282360.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    209. Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C907-16. Platoshyn O, Brevnova EE, Burg ED, Yu Y, Remillard CV, Yuan JX. PMID: 16236819; PMCID: PMC1363730.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    210. Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension. Exp Lung Res. 2005 Oct; 31(8):783-806. Fantozzi I, Huang W, Zhang J, Zhang S, Platoshyn O, Remillard CV, Thistlethwaite PA, Yuan JX. PMID: 16368652; PMCID: PMC1409757.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    211. Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C325-36. Mauban JR, Wilkinson K, Schach C, Yuan JX. PMID: 16162658; PMCID: PMC1351365.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    212. Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells. Pflugers Arch. 2005 Nov; 451(2):380-387. Platoshyn O, Remillard CV, Fantozzi I, Sison T, Yuan JX. PMID: 16052353; PMCID: PMC1351366.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    213. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2356-63. Iwata M, Cowling RT, Gurantz D, Moore C, Zhang S, Yuan JX, Greenberg BH. PMID: 16024575.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    214. PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you? Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L789-92. Remillard CV, Yuan JX. PMID: 15821019.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    215. ClC-3: more than just a volume-sensitive Cl- channel. Br J Pharmacol. 2005 May; 145(1):1-2. Remillard CV, Yuan JX. PMID: 15723095; PMCID: PMC1576112.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    216. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. PMID: 15703750; PMCID: PMC5578466.
      View in: PubMed   Mentions: 459     Fields:    Translation:HumansAnimalsCells
    217. Pathogenesis of pulmonary arterial hypertension: the need for multiple hits. Circulation. 2005 Feb 08; 111(5):534-8. Yuan JX, Rubin LJ. PMID: 15699271.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    218. Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways. Cell Biochem Biophys. 2005; 43(3):365-77. Keller SH, Platoshyn O, Yuan JX. PMID: 16244363.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    219. Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis. Cell Biochem Biophys. 2005; 42(1):41-53. Tsigelny I, Hotchko M, Yuan JX, Keller SH. PMID: 15673927.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    220. Hypoxic pulmonary vasoconstriction: role of ion channels. J Appl Physiol (1985). 2005 Jan; 98(1):415-20. Mauban JR, Remillard CV, Yuan JX. PMID: 15591311.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    221. High altitude pulmonary hypertension: role of K+ and Ca2+ channels. High Alt Med Biol. 2005; 6(2):133-46. Remillard CV, Yuan JX. PMID: 16060848; PMCID: PMC1351363.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    222. Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2005 Feb; 288(2):C245-52. Zhang S, Yuan JX, Barrett KE, Dong H. PMID: 15456699.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    223. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13861-6. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. PMID: 15358862; PMCID: PMC518765.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    224. Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension. Microvasc Res. 2004 Sep; 68(2):75-103. Mandegar M, Fung YC, Huang W, Remillard CV, Rubin LJ, Yuan JX. PMID: 15313118.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    225. Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1101-7. Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite PA, Rubin LJ, Yuan JX. PMID: 15317671.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    226. Molecular biology of primary pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):417-29, vi. Mandegar M, Thistlethwaite PA, Yuan JX. PMID: 15302361.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    227. ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1192-201. Zhang S, Remillard CV, Fantozzi I, Yuan JX. PMID: 15229105.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    228. Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L962-9. Kunichika N, Yu Y, Remillard CV, Platoshyn O, Zhang S, Yuan JX. PMID: 15220115.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    229. Overexpression of human KCNA5 increases IK V and enhances apoptosis. Am J Physiol Cell Physiol. 2004 Sep; 287(3):C715-22. Brevnova EE, Platoshyn O, Zhang S, Yuan JX. PMID: 15140747.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    230. Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci. 2004 Apr; 19:44-50. Landsberg JW, Yuan JX. PMID: 15016901.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    231. Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L226-38. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. PMID: 15047570.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    232. Activation of K+ channels: an essential pathway in programmed cell death. Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L49-67. Remillard CV, Yuan JX. PMID: 14656699.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimals
    233. Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1233-45. Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JX. PMID: 12909593.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    234. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L740-54. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX. PMID: 12740218.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    235. Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med. 2003 Feb 06; 348(6):500-9. Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethwaite PA. PMID: 12571257.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    236. PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol. 2003 Feb; 284(2):C316-30. Yu Y, Sweeney M, Zhang S, Platoshyn O, Landsberg J, Rothman A, Yuan JX. PMID: 12529250.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    237. Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents. Am J Physiol Cell Physiol. 2003 Jun; 284(6):C1405-10. Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX. PMID: 12734105.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    238. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C848-59. Rao JN, Guo X, Liu L, Zou T, Murthy KS, Yuan JX, Wang JY. PMID: 12466151.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    239. Cytochrome c activates K+ channels before inducing apoptosis. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1298-305. Platoshyn O, Zhang S, McDaniel SS, Yuan JX. PMID: 12225992.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    240. Ion channels in pulmonary arterial hypertension. Prog Cardiovasc Dis. 2002 Sep-Oct; 45(2):81-114. Mandegar M, Remillard CV, Yuan JX. PMID: 12411972.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    241. Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L144-55. Sweeney M, Yu Y, Platoshyn O, Zhang S, McDaniel SS, Yuan JX. PMID: 12060571.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    242. Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J Appl Physiol (1985). 2002 Apr; 92(4):1594-602. Sweeney M, McDaniel SS, Platoshyn O, Zhang S, Yu Y, Lapp BR, Zhao Y, Thistlethwaite PA, Yuan JX. PMID: 11896026.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    243. Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding. Am J Physiol Cell Physiol. 2002 Apr; 282(4):C885-98. Rao JN, Platoshyn O, Li L, Guo X, Golovina VA, Yuan JX, Wang JY. PMID: 11880277.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    244. Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H184-93. Krick S, Platoshyn O, Sweeney M, McDaniel SS, Zhang S, Rubin LJ, Yuan JX. PMID: 11748062.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    245. Role of K+ channels in pulmonary hypertension. Vascul Pharmacol. 2002 Jan; 38(1):25-33. Mandegar M, Yuan JX. PMID: 12378819.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells