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Jason Ear

Title(s)Postdoctoral Scholar, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: DAPLE protein inhibits nucleotide exchange on Gas and Gaq via the same motif that activates Gai. J Biol Chem. 2020 Jun 26; 295(26):8867. Marivin A, Maziarz M, Zhao J, DiGiacomo V, Calvo IO, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M. PMID: 32591443.
      View in: PubMed   Mentions:    Fields:    
    2. Tyrosine-Based Signals Regulate the Assembly of Daple·PARD3 Complex at Cell-Cell Junctions. iScience. 2020 Feb 21; 23(2):100859. Ear J, Saklecha A, Rajapakse N, Choi J, Ghassemian M, Kufareva I, Ghosh P. PMID: 32058970.
      View in: PubMed   Mentions:
    3. DAPLE protein inhibits nucleotide exchange on Gas and Gaq via the same motif that activates Gai. J Biol Chem. 2020 02 21; 295(8):2270-2284. Marivin A, Maziarz M, Zhao J, DiGiacomo V, Olmos Calvo I, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M. PMID: 31949046.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Sci Rep. 2019 08 20; 9(1):12124. Ear J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. PMID: 31431650.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma. Sci Rep. 2018 12 21; 8(1):18036. Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, Ghosh P. PMID: 30575751.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018 02 27; 11(519). Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. PMID: 29487190.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing ß-catenin. Mol Biol Cell. 2017 Dec 01; 28(25):3709-3723. Aznar N, Sun N, Dunkel Y, Ear J, Buschman MD, Ghosh P. PMID: 29021338.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. RNA methylation regulates hematopoietic stem and progenitor cell development. J Genet Genomics. 2017 10 20; 44(10):473-474. Ear J, Lin S. PMID: 29037987.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin. Curr Protoc Chem Biol. 2016 Dec 07; 8(4):265-298. Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C, Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D. PMID: 27925669.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. GIV/Girdin activates Gai and inhibits Gas via the same motif. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5721-30. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. PMID: 27621449.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. J Genet Genomics. 2016 05 20; 43(5):307-18. Ear J, Hsueh J, Nguyen M, Zhang Q, Sung V, Chopra R, Sakamoto KM, Lin S. PMID: 27216296.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1. Blood. 2015 Aug 13; 126(7):880-90. Ear J, Huang H, Wilson T, Tehrani Z, Lindgren A, Sung V, Laadem A, Daniel TO, Chopra R, Lin S. PMID: 26109203.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    13. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov 05; 25(22):3654-71. Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. PMID: 25187647.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    14. Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death Dis. 2014 Jul 24; 5:e1352. Zhang Y, Ear J, Yang Z, Morimoto K, Zhang B, Lin S. PMID: 25058426.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    15. Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 2013 May 27; 9(9-10):1776-85. Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. PMID: 23180726.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    16. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 07; 19(12):1826-36. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. PMID: 22153505.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    17. Tyrosine phosphorylation of the Ga-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27; 4(192):ra64. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. PMID: 21954290.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    18. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J Mol Biol. 2011 Sep 09; 412(1):3-13. Stafford RL, Ear J, Knight MJ, Bowie JU. PMID: 21763699.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011 Mar 01; 22(5):673-86. Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. PMID: 21209316.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    20. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb; 25(2):590-9. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. PMID: 20974669.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    21. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 01; 21(13):2338-54. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. PMID: 20462955.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    22. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010 Apr 23; 285(17):12765-77. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. PMID: 20157114.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells