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Jason Ear

Title(s)Postdoctoral Scholar, Cellular and Molecular Medicine
SchoolHealth Sciences
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ear J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Sci Rep. 2019 Aug 20; 9(1):12124. PMID: 31431650.
      View in: PubMed
    2. Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, Ghosh P. Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma. Sci Rep. 2018 12 21; 8(1):18036. PMID: 30575751.
      View in: PubMed
    3. Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018 02 27; 11(519). PMID: 29487190.
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    4. Aznar N, Sun N, Dunkel Y, Ear J, Buschman MD, Ghosh P. A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing ß-catenin. Mol Biol Cell. 2017 Dec 01; 28(25):3709-3723. PMID: 29021338.
      View in: PubMed
    5. Ear J, Lin S. RNA methylation regulates hematopoietic stem and progenitor cell development. J Genet Genomics. 2017 10 20; 44(10):473-474. PMID: 29037987.
      View in: PubMed
    6. Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C, Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D. Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin. Curr Protoc Chem Biol. 2016 Dec 07; 8(4):265-298. PMID: 27925669.
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    7. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. GIV/Girdin activates Gai and inhibits Gas via the same motif. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5721-30. PMID: 27621449.
      View in: PubMed
    8. Ear J, Hsueh J, Nguyen M, Zhang Q, Sung V, Chopra R, Sakamoto KM, Lin S. A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. J Genet Genomics. 2016 05 20; 43(5):307-18. PMID: 27216296.
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    9. Ear J, Huang H, Wilson T, Tehrani Z, Lindgren A, Sung V, Laadem A, Daniel TO, Chopra R, Lin S. RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1. Blood. 2015 Aug 13; 126(7):880-90. PMID: 26109203.
      View in: PubMed
    10. Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov 05; 25(22):3654-71. PMID: 25187647.
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    11. Zhang Y, Ear J, Yang Z, Morimoto K, Zhang B, Lin S. Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death Dis. 2014 Jul 24; 5:e1352. PMID: 25058426.
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    12. Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 2013 May 27; 9(9-10):1776-85. PMID: 23180726.
      View in: PubMed
    13. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 07; 19(12):1826-36. PMID: 22153505.
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    14. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. Tyrosine phosphorylation of the Ga-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27; 4(192):ra64. PMID: 21954290.
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    15. Stafford RL, Ear J, Knight MJ, Bowie JU. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J Mol Biol. 2011 Sep 09; 412(1):3-13. PMID: 21763699.
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    16. Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011 Mar 01; 22(5):673-86. PMID: 21209316.
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    17. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb; 25(2):590-9. PMID: 20974669.
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    18. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 01; 21(13):2338-54. PMID: 20462955.
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    19. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010 Apr 23; 285(17):12765-77. PMID: 20157114.
      View in: PubMed