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    James Martin

    TitleAssistant Clinical Professor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0984
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Optical elastography for assessment of myocardial regeneration
      NIH/NHLBI R01HL130804Jun 1, 2016 - Mar 31, 2020
      Role: Co-Principal Investigator
      Hippo and Wnt signaling in cardiac regeneration
      NIH/NHLBI R01HL127717Jan 15, 2016 - Dec 31, 2019
      Role: Principal Investigator
      Pitx2 in atrial fibrillation
      NIH/NHLBI R01HL118761Apr 1, 2014 - Jan 31, 2022
      Role: Principal Investigator
      MicroRNAs in cleft lip and palate
      NIH/NIDCR R01DE023177Dec 4, 2012 - Nov 30, 2017
      Role: Principal Investigator
      Pitx2 Function in Cardiac Development
      NIH/NHLBI R01HL093484Apr 1, 2009 - Mar 31, 2013
      Role: Principal Investigator
      Weinstein Cardiovascular Development Conference
      NIH/NHLBI R13HL091580Jan 12, 2008 - Nov 30, 2012
      Role: Co-Principal Investigator
      PITX2 AND WNT'S IN CRANIOFACIAL DEVELOPMENT
      NIH/NIDCR R01DE016329Aug 1, 2005 - Jun 30, 2010
      Role: Principal Investigator
      RIEGER GENE FUNCTION IN TOOTH DEVELOPMENT
      NIH/NIDCR R01DE013509Jul 1, 2001 - May 31, 2006
      Role: Principal Investigator
      Bmp-signaling in craniofacial development
      NIH/NIDCR R01DE012324Jul 1, 1997 - Jun 30, 2014
      Role: Principal Investigator
      PAIRED RELATED HOMEOBOX GENES IN CRANIAL DEVELOPMENT
      NIH/NIDCR R29DE012324Jul 1, 1997 - Jun 30, 2002
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. van Vliet PP, Lin L, Boogerd CJ, Martin J, Andelfinger G, Grossfeld PD, Evans SM. Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Dev Biol. 2017 Sep 01; 429(1):249-259. PMID: 28669819.
        View in: PubMed
      2. Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin J, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP. Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm. Sci Transl Med. 2016 Aug 31; 8(354):354ra115. PMID: 27582060.
        View in: PubMed
      3. Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA, Martin J. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016 06 02; 534(7605):119-23. PMID: 27251288; PMCID: PMC4999251 [Available on 12/02/16].
      4. Poché RA, Zhang M, Rueda EM, Tong X, McElwee ML, Wong L, Hsu CW, Dejosez M, Burns AR, Fox DA, Martin J, Zwaka TP, Dickinson ME. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Cell Rep. 2016 Feb 23; 14(7):1684-1697. PMID: 26876175; PMCID: PMC4767647.
      5. Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin J. Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development. 2016 Feb 01; 143(3):504-15. PMID: 26718006; PMCID: PMC4760309 [Available on 02/01/17].
      6. Morikawa Y, Zhang M, Heallen T, Leach J, Tao G, Xiao Y, Bai Y, Li W, Willerson JT, Martin J. Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. Sci Signal. 2015 May 05; 8(375):ra41. PMID: 25943351; PMCID: PMC4442128.
      7. Heallen T, Morikawa Y, Leach J, Tao G, Willerson JT, Johnson RL, Martin J. Hippo signaling impedes adult heart regeneration. Development. 2013 Dec; 140(23):4683-90. PMID: 24255096; PMCID: PMC3833428.
      8. Bai Y, Wang J, Morikawa Y, Bonilla-Claudio M, Klysik E, Martin J. Bmp signaling represses Vegfa to promote outflow tract cushion development. Development. 2013 Aug; 140(16):3395-402. PMID: 23863481; PMCID: PMC3737720.
      9. Waite MR, Skidmore JM, Micucci JA, Shiratori H, Hamada H, Martin J, Martin DM. Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development. Mol Cell Neurosci. 2013 Jan; 52:128-39. PMID: 23147109; PMCID: PMC3540135.
      10. Klaus A, Müller M, Schulz H, Saga Y, Martin J, Birchmeier W. Wnt/ß-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10921-6. PMID: 22711842; PMCID: PMC3390862.
      11. Bonilla-Claudio M, Wang J, Bai Y, Klysik E, Selever J, Martin J. Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development. 2012 Feb; 139(4):709-19. PMID: 22219353; PMCID: PMC3265059.
      12. Zhang J, Liu J, Huang Y, Chang JY, Liu L, McKeehan WL, Martin J, Wang F. FRS2a-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res. 2012 Feb 17; 110(4):e29-39. PMID: 22207710; PMCID: PMC3677753.
      13. Waite MR, Skaggs K, Kaviany P, Skidmore JM, Causeret F, Martin J, Martin DM. Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2. Mol Cell Neurosci. 2012 Jan; 49(1):32-43. PMID: 21925604; PMCID: PMC3244529.
      14. Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin J. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22; 332(6028):458-61. PMID: 21512031; PMCID: PMC3133743.
      15. Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin J. Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14; 19(6):903-12. PMID: 21145505; PMCID: PMC3010389.
      16. Wang Y, Martin J, Bai CB. Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol. 2010 Dec 15; 348(2):199-209. PMID: 20934421; PMCID: PMC3200223.
      17. Zhang J, Chang JY, Huang Y, Lin X, Luo Y, Schwartz RJ, Martin J, Wang F. The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. Circ Res. 2010 Nov 12; 107(10):1209-19. PMID: 20847311; PMCID: PMC3052773.
      18. Zhang Z, Florez S, Gutierrez-Hartmann A, Martin J, Amendt BA. MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem. 2010 Nov 05; 285(45):34718-28. PMID: 20807761; PMCID: PMC2966087.
      19. Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin J. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9753-8. PMID: 20457925; PMCID: PMC2906838.
      20. Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin J, Wang D, Yang J, Chen Y. Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol. 2009 Mar 15; 327(2):376-85. PMID: 19166829; PMCID: PMC2694185.
      21. Niu Z, Iyer D, Conway SJ, Martin J, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17824-9. PMID: 19004760; PMCID: PMC2584699.
      22. McCulley DJ, Kang JO, Martin J, Black BL. BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn. 2008 Nov; 237(11):3200-9. PMID: 18924235; PMCID: PMC2728547.
      23. Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin J, Wang F. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 2008 Nov; 135(21):3611-22. PMID: 18832393; PMCID: PMC3262991.
      24. Davis NM, Kurpios NA, Sun X, Gros J, Martin J, Tabin CJ. The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery. Dev Cell. 2008 Jul; 15(1):134-45. PMID: 18606147; PMCID: PMC2528248.
      25. Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin J, Amendt BA, Liu M. Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6081-6. PMID: 18424556; PMCID: PMC2329706.
      26. Amen M, Espinoza HM, Cox C, Liang X, Wang J, Link TM, Brennan RG, Martin J, Amendt BA. Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. Nucleic Acids Res. 2008 Feb; 36(2):462-76. PMID: 18045789; PMCID: PMC2241859.
      27. Ai D, Wang J, Amen M, Lu MF, Amendt BA, Martin J. Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development. Mol Cell Biol. 2007 Aug; 27(16):5765-75. PMID: 17562863; PMCID: PMC1952127.
      28. Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin J. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9319-24. PMID: 17519332; PMCID: PMC1890492.
      29. Lee KY, Jeong JW, Wang J, Ma L, Martin J, Tsai SY, Lydon JP, DeMayo FJ. Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol. 2007 Aug; 27(15):5468-78. PMID: 17515606; PMCID: PMC1952078.
      30. Dong F, Sun X, Liu W, Ai D, Klysik E, Lu MF, Hadley J, Antoni L, Chen L, Baldini A, Francis-West P, Martin J. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development. 2006 Dec; 133(24):4891-9. PMID: 17107996.
        View in: PubMed
      31. Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin J. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 2006 Aug 15; 296(2):437-49. PMID: 16836994.
        View in: PubMed
      32. Ovchinnikov DA, Selever J, Wang Y, Chen YT, Mishina Y, Martin J, Behringer RR. BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. Dev Biol. 2006 Jul 01; 295(1):103-15. PMID: 16630606.
        View in: PubMed
      33. Ma L, Lu MF, Schwartz RJ, Martin J. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development. 2005 Dec; 132(24):5601-11. PMID: 16314491.
        View in: PubMed
      34. Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, Zhang Z, Martin J, Behringer RR, Nakamura T, de Crombrugghe B. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14665-70. PMID: 16203988; PMCID: PMC1239942.
      35. Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin J. Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol. 2005 Jul 15; 283(2):282-93. PMID: 15936012.
        View in: PubMed
      36. Selever J, Liu W, Lu MF, Behringer RR, Martin J. Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol. 2004 Dec 15; 276(2):268-79. PMID: 15581864.
        View in: PubMed
      37. Liu W, Selever J, Wang D, Lu MF, Moses KA, Schwartz RJ, Martin J. Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4489-94. PMID: 15070745; PMCID: PMC384774.
      38. Liu W, Selever J, Lu MF, Martin J. Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development. 2003 Dec; 130(25):6375-85. PMID: 14623826.
        View in: PubMed
      39. Liu C, Liu W, Palie J, Lu MF, Brown NA, Martin J. Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov; 129(21):5081-91. PMID: 12397115.
        View in: PubMed
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