James Hagood

InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0731
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Targeted Therapies for Pulmonary Fibrosis
    NIH P01HL119165Mar 3, 2015 - Feb 29, 2020
    Role: Co-Investigator
    Alveolar DevMAP
    NIH/NHLBI U01HL122626Jun 15, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Targeting the Apoptosis-Resistant Pulmonary Myofibroblast
    NIH/NHLBI R01HL111169Aug 1, 2012 - May 31, 2016
    Role: Principal Investigator
    Childhood Interstitial &Diffuse Lung Disease Scientific Conference
    NIH/NHLBI R13HL114359Jun 1, 2012 - May 31, 2013
    Role: Principal Investigator
    Epigenetic Alterations in IPF Fibroblastic Foci
    NIH/NHLBI R03HL097006May 11, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Regulation of Fibroblast Phenotype in Lung Fibrosis
    NIH/NHLBI R01HL082818Dec 1, 2005 - Jun 30, 2018
    Role: Principal Investigator
    Role of Fibroblast Thy-1 in Pulmonary Fibrosis
    NIH/NHLBI R01HL065348May 22, 2002 - Mar 31, 2006
    Role: Principal Investigator
    NIH/NIAMS R03AR046378Aug 1, 2000 - Jul 31, 2003
    Role: Principal Investigator
    NIH/NHLBI K08HL003239Dec 1, 1994 - Nov 30, 1999
    Role: Principal Investigator
    NIH P60AR020614Sep 20, 1977 - Dec 31, 2002
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ding J, Hagood J, Ambalavanan N, Kaminski N, Bar-Joseph Z. iDREM: Interactive visualization of dynamic regulatory networks. PLoS Comput Biol. 2018 03; 14(3):e1006019. PMID: 29538379.
      View in: PubMed
    2. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood J, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Extracellular matrix in lung development, homeostasis and disease. Matrix Biol. 2018 Mar 08. PMID: 29524630.
      View in: PubMed
    3. Shentu TP, Huang TS, Cernelc-Kohan M, Chan J, Wong SS, Espinoza CR, Tan C, Gramaglia I, van der Heyde H, Chien S, Hagood J. Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation. Sci Rep. 2017 Dec 22; 7(1):18052. PMID: 29273797.
      View in: PubMed
    4. Joshi S, Singh AR, Wong SS, Zulcic M, Jiang M, Pardo A, Selman M, Hagood J, Durden DL. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. PLoS One. 2017; 12(8):e0182851. PMID: 28817691.
      View in: PubMed
    5. Ardini-Poleske ME, Clark RF, Ansong C, Carson JP, Corley RA, Deutsch GH, Hagood J, Kaminski N, Mariani TJ, Potter SS, Pryhuber GS, Warburton D, Whitsett JA, Palmer SM, Ambalavanan N. LungMAP: The Molecular Atlas of Lung Development Program. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L733-L740. PMID: 28798251.
      View in: PubMed
    6. Liu X, Wong SS, Taype CA, Kim J, Shentu TP, Espinoza CR, Finley JC, Bradley JE, Head BP, Patel HH, Mah EJ, Hagood J. Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution. Lab Invest. 2017 03; 97(3):256-267. PMID: 28165468.
      View in: PubMed
    7. Kleyman M, Sefer E, Nicola T, Espinoza C, Chhabra D, Hagood J, Kaminski N, Ambalavanan N, Bar-Joseph Z. Selecting the most appropriate time points to profile in high-throughput studies. Elife. 2017 Jan 26; 6. PMID: 28124972.
      View in: PubMed
    8. Dietz AC, Chen Y, Yasui Y, Ness KK, Hagood J, Chow EJ, Stovall M, Neglia JP, Oeffinger KC, Mertens AC, Robison LL, Armstrong GT, Mulrooney DA. Risk and impact of pulmonary complications in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer. 2016 Dec 01; 122(23):3687-3696. PMID: 27504874.
      View in: PubMed
    9. Glasser SW, Hagood J, Wong S, Taype CA, Madala SK, Hardie WD. Mechanisms of Lung Fibrosis Resolution. Am J Pathol. 2016 05; 186(5):1066-77. PMID: 27021937; PMCID: PMC4861766 [Available on 05/01/17].
    10. Checa M, Hagood J, Velazquez-Cruz R, Ruiz V, García-De-Alba C, Rangel-Escareño C, Urrea F, Becerril C, Montaño M, García-Trejo S, Cisneros Lira J, Aquino-Gálvez A, Pardo A, Selman M. Cigarette Smoke Enhances the Expression of Profibrotic Molecules in Alveolar Epithelial Cells. PLoS One. 2016; 11(3):e0150383. PMID: 26934369; PMCID: PMC4775036.
    11. Craig VJ, Zhang L, Hagood J, Owen CA. Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):585-600. PMID: 26121236; PMCID: PMC4742954 [Available on 11/01/16].
    12. Fiore VF, Strane PW, Bryksin AV, White ES, Hagood J, Barker TH. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015 Oct 12; 211(1):173-90. PMID: 26459603; PMCID: PMC4602038.
    13. Fan LL, Dishop MK, Galambos C, Askin FB, White FV, Langston C, Liptzin DR, Kroehl ME, Deutsch GH, Young LR, Kurland G, Hagood J, Dell S, Trapnell BC, Deterding RR. Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme. Ann Am Thorac Soc. 2015 Oct; 12(10):1498-505. PMID: 26291470; PMCID: PMC4627419 [Available on 10/01/16].
    14. Ebrahim M, Hagood J, Moore J, El-Said H. Bronchoscopic guidance of endovascular stenting limits airway compression. Catheter Cardiovasc Interv. 2015 Apr; 85(5):832-6. PMID: 25504498.
      View in: PubMed
    15. Hagood J. Beyond the genome: epigenetic mechanisms in lung remodeling. Physiology (Bethesda). 2014 May; 29(3):177-85. PMID: 24789982; PMCID: PMC4046816.
    16. Sanders YY, Hagood J, Liu H, Zhang W, Ambalavanan N, Thannickal VJ. Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J. 2014 May; 43(5):1448-58. PMID: 24603818.
      View in: PubMed
    17. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood J, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. PMID: 24160862; PMCID: PMC3983890.
    18. Leyton L, Hagood J. Thy-1 modulates neurological cell-cell and cell-matrix interactions through multiple molecular interactions. Adv Neurobiol. 2014; 8:3-20. PMID: 25300130.
      View in: PubMed
    19. Ross MK, Ellis LS, Bird LM, Hagood J. Pulmonary interstitial glycogenosis in a patient ultimately diagnosed with Noonan syndrome. Pediatr Pulmonol. 2014 May; 49(5):508-11. PMID: 24039098.
      View in: PubMed
    20. Harris WT, Kelly DR, Zhou Y, Wang D, MacEwen M, Macewen M, Hagood J, Clancy JP, Ambalavanan N, Sorscher EJ. Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease. PLoS One. 2013; 8(8):e70196. PMID: 23950911; PMCID: PMC3741283.
    21. Kurland G, Deterding RR, Hagood J, Young LR, Brody AS, Castile RG, Dell S, Fan LL, Hamvas A, Hilman BC, Langston C, Nogee LM, Redding GJ. An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):376-94. PMID: 23905526; PMCID: PMC3778735.
    22. Hamvas A, Deterding R, Balch WE, Schwartz DA, Albertine KH, Whitsett JA, Cardoso WV, Kotton DN, Kourembanas S, Hagood J. Diffuse lung disease in children: summary of a scientific conference. Pediatr Pulmonol. 2014 Apr; 49(4):400-9. PMID: 23798474; PMCID: PMC4145861.
    23. Stokes DC, McBride JT, Hagood J, Lesser DJ, Taylor JB. The (pediatric pulmonary) world is flat. The spread of Internet-based pediatric pulmonary case conferences. Ann Am Thorac Soc. 2013 Jun; 10(3):274-5. PMID: 23802832.
      View in: PubMed
    24. Bradley JE, Chan JM, Hagood J. Effect of the GPI anchor of human Thy-1 on antibody recognition and function. Lab Invest. 2013 Mar; 93(3):365-74. PMID: 23358110.
      View in: PubMed
    25. Hagood J, Ambalavanan N. Systems biology of lung development and regeneration: current knowledge and recommendations for future research. Wiley Interdiscip Rev Syst Biol Med. 2013 Mar-Apr; 5(2):125-33. PMID: 23293056.
      View in: PubMed
    26. Dell S, Cernelc-Kohan M, Hagood J. Diffuse and interstitial lung disease and childhood rheumatologic disorders. Curr Opin Rheumatol. 2012 Sep; 24(5):530-40. PMID: 22820514.
      View in: PubMed
    27. Cisneros J, Hagood J, Checa M, Ortiz-Quintero B, Negreros M, Herrera I, Ramos C, Pardo A, Selman M. Hypermethylation-mediated silencing of p14(ARF) in fibroblasts from idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L295-303. PMID: 22707614.
      View in: PubMed
    28. Sanders YY, Ambalavanan N, Halloran B, Zhang X, Liu H, Crossman DK, Bray M, Zhang K, Thannickal VJ, Hagood J. Altered DNA methylation profile in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012 Sep 15; 186(6):525-35. PMID: 22700861; PMCID: PMC3480526.
    29. Thannickal VJ, Hagood J. Biological insights from clinical trials and networks. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):475-6. PMID: 22383567; PMCID: PMC3297100.
    30. Varisco BM, Ambalavanan N, Whitsett JA, Hagood J. Thy-1 signals through PPAR? to promote lipofibroblast differentiation in the developing lung. Am J Respir Cell Mol Biol. 2012 Jun; 46(6):765-72. PMID: 22268140; PMCID: PMC3380285.
    31. Huang WT, Vayalil PK, Miyata T, Hagood J, Liu RM. Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):87-95. PMID: 21852684; PMCID: PMC3262658.
    32. Nuovo GJ, Hagood J, Magro CM, Chin N, Kapil R, Davis L, Marsh CB, Folcik VA. The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis. Mod Pathol. 2012 Mar; 25(3):416-33. PMID: 22037258; PMCID: PMC3270219.
    33. Kis K, Liu X, Hagood J. Myofibroblast differentiation and survival in fibrotic disease. Expert Rev Mol Med. 2011 Aug 23; 13:e27. PMID: 21861939.
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    34. Ramírez G, Hagood J, Sanders Y, Ramírez R, Becerril C, Segura L, Barrera L, Selman M, Pardo A. Absence of Thy-1 results in TGF-ß induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts. Lab Invest. 2011 Aug; 91(8):1206-18. PMID: 21577212.
      View in: PubMed
    35. Sanders YY, Tollefsbol TO, Varisco BM, Hagood J. Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. Am J Respir Cell Mol Biol. 2011 Jul; 45(1):16-23. PMID: 20724553; PMCID: PMC3145068.
    36. Shan B, Hagood J, Zhuo Y, Nguyen HT, MacEwen M, Morris GF, Lasky JA. Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase. PLoS One. 2010 Jul 19; 5(7):e11662. PMID: 20657842; PMCID: PMC2906514.
    37. Hardie WD, Hagood J, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle. 2010 Jul 15; 9(14):2769-76. PMID: 20676040; PMCID: PMC3040960.
    38. Zhou Y, Hagood J, Lu B, Merryman WD, Murphy-Ullrich JE. Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation. J Biol Chem. 2010 Jul 16; 285(29):22382-93. PMID: 20463011; PMCID: PMC2903374.
    39. Liu RM, Choi J, Wu JH, Gaston Pravia KA, Lewis KM, Brand JD, Mochel NS, Krzywanski DM, Lambeth JD, Hagood J, Forman HJ, Thannickal VJ, Postlethwait EM. Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem. 2010 May 21; 285(21):16239-47. PMID: 20228065; PMCID: PMC2871491.
    40. Glasser SW, Hardie WD, Hagood J. Pathogenesis of Interstitial Lung Disease in Children and Adults. Pediatr Allergy Immunol Pulmonol. 2010 Mar; 23(1):9-14. PMID: 22087431.
      View in: PubMed
    41. Deterding RR, Brody AS, Hagood J, Young LR. Round Table Discussion: Children's Interstitial Lung Disease. Pediatr Allergy Immunol Pulmonol. 2010 Mar; 23(1):91-96. PMID: 22332034.
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    42. McDougal J, Gettys A, Hagood J. ChILD Family Education. Pediatr Allergy Immunol Pulmonol. 2010 Mar; 23(1):87-90. PMID: 22332033.
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    43. Li X, Atkinson TP, Hagood J, Makris C, Duffy LB, Waites KB. Emerging macrolide resistance in Mycoplasma pneumoniae in children: detection and characterization of resistant isolates. Pediatr Infect Dis J. 2009 Aug; 28(8):693-6. PMID: 19633515.
      View in: PubMed
    44. Hardie WD, Glasser SW, Hagood J. Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol. 2009 Jul; 175(1):3-16. PMID: 19497999; PMCID: PMC2708789.
    45. Bradley JE, Ramirez G, Hagood J. Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype. Biofactors. 2009 May-Jun; 35(3):258-65. PMID: 19422052.
      View in: PubMed
    46. Nicola T, Hagood J, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, Ambalavanan N. Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am J Physiol Lung Cell Mol Physiol. 2009 May; 296(5):L738-50. PMID: 19270178; PMCID: PMC2681351.
    47. Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood J, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Proc Am Thorac Soc. 2009 Jan 15; 6(1):1-10. PMID: 19131525.
      View in: PubMed
    48. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood J, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan; 44(1):2-13. PMID: 19086051.
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    49. Shaik SS, Soltau TD, Chaturvedi G, Totapally B, Hagood J, Andrews WW, Athar M, Voitenok NN, Killingsworth CR, Patel RP, Fallon MB, Maheshwari A. Low intensity shear stress increases endothelial ELR+ CXC chemokine production via a focal adhesion kinase-p38{beta} MAPK-NF-{kappa}B pathway. J Biol Chem. 2009 Feb 27; 284(9):5945-55. PMID: 19117939; PMCID: PMC2645838.
    50. Zhou Y, Koli K, Hagood J, Miao M, Mavalli M, Rifkin DB, Murphy-Ullrich JE. Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin. Am J Pathol. 2009 Jan; 174(1):21-33. PMID: 19056849; PMCID: PMC2631315.
    51. Barker TH, Hagood J. Getting a grip on Thy-1 signaling. Biochim Biophys Acta. 2009 May; 1793(5):921-3. PMID: 19007822; PMCID: PMC2701903.
    52. Sanders YY, Pardo A, Selman M, Nuovo GJ, Tollefsbol TO, Siegal GP, Hagood J. Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):610-8. PMID: 18556592; PMCID: PMC2574530.
    53. Ambalavanan N, Nicola T, Hagood J, Bulger A, Serra R, Murphy-Ullrich J, Oparil S, Chen YF. Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L86-95. PMID: 18487357; PMCID: PMC2494779.
    54. Hagood J, Olman MA. Muscle fatigue: MK2 signaling and myofibroblast differentiation. Am J Respir Cell Mol Biol. 2007 Nov; 37(5):503-6. PMID: 17940320; PMCID: PMC2720146.
    55. Rege TA, Pallero MA, Gomez C, Grenett HE, Murphy-Ullrich JE, Hagood J. Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I. Exp Cell Res. 2006 Nov 15; 312(19):3752-67. PMID: 17027000.
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    56. Sanders YY, Kumbla P, Hagood J. Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):226-35. PMID: 16960126; PMCID: PMC2720117.
    57. Rege TA, Hagood J. Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses. Biochim Biophys Acta. 2006 Oct; 1763(10):991-9. PMID: 16996153; PMCID: PMC1781924.
    58. Rege TA, Hagood J. Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis. FASEB J. 2006 Jun; 20(8):1045-54. PMID: 16770003.
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    59. Hagood J, Prabhakaran P, Kumbla P, Salazar L, MacEwen MW, Barker TH, Ortiz LA, Schoeb T, Siegal GP, Alexander CB, Pardo A, Selman M. Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol. 2005 Aug; 167(2):365-79. PMID: 16049324; PMCID: PMC1603564.
    60. Arnold DH, Spiro DM, Desmond RA, Hagood J. Estimation of airway obstruction using oximeter plethysmograph waveform data. Respir Res. 2005 Jun 28; 6:65. PMID: 15985171; PMCID: PMC1168908.
    61. Hagood J, Lenker CV, Thrasher S. A course on the transition to adult care of patients with childhood-onset chronic illnesses. Acad Med. 2005 Apr; 80(4):352-5. PMID: 15793019.
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    62. Zhou Y, Hagood J, Murphy-Ullrich JE. Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. Am J Pathol. 2004 Aug; 165(2):659-69. PMID: 15277239; PMCID: PMC1618578.
    63. Barker TH, Grenett HE, MacEwen MW, Tilden SG, Fuller GM, Settleman J, Woods A, Murphy-Ullrich J, Hagood J. Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. Exp Cell Res. 2004 May 01; 295(2):488-96. PMID: 15093746.
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    64. Barker TH, Pallero MA, MacEwen MW, Tilden SG, Woods A, Murphy-Ullrich JE, Hagood J. Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation. J Biol Chem. 2004 May 28; 279(22):23510-6. PMID: 15033989.
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    65. Hagood J, Mangalwadi A, Guo B, MacEwen MW, Salazar L, Fuller GM. Concordant and discordant interleukin-1-mediated signaling in lung fibroblast thy-1 subpopulations. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):702-8. PMID: 12034569.
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