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Isaac Chaim

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0651
La Jolla CA 92093
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    1. Chaim I, Nagel ZD, Jordan JJ, Mazzucato P, Ngo LP, Samson LD. In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. Proc Natl Acad Sci U S A. 2017 Nov 28; 114(48):E10379-E10388. PMID: 29122935.
      View in: PubMed
    2. Margulies CM, Chaim I, Mazumder A, Criscione J, Samson LD. Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms. PLoS One. 2017; 12(9):e0184619. PMID: 28886188.
      View in: PubMed
    3. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim I, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. PMID: 28803727.
      View in: PubMed
    4. Chaim I, Gardner A, Wu J, Iyama T, Wilson DM, Samson LD. A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine. Nucleic Acids Res. 2017 Apr 07; 45(6):3242-3252. PMID: 28115629.
      View in: PubMed
    5. Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim I, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD. DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme. Cancer Res. 2017 01 01; 77(1):198-206. PMID: 27793847.
      View in: PubMed
    6. Nagel ZD, Chaim I, Samson LD. Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. DNA Repair (Amst). 2014 Jul; 19:199-213. PMID: 24780560; PMCID: PMC4071454.
    7. Nagel ZD, Margulies CM, Chaim I, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD. Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):E1823-32. PMID: 24757057; PMCID: PMC4020053.
    8. Chaim I, Sabino MA, Mendt M, Müller AJ, Ajami D. Evaluation of the potential of novel PCL-PPDX biodegradable scaffolds as support materials for cartilage tissue engineering. J Tissue Eng Regen Med. 2012 Apr; 6(4):272-9. PMID: 21548137.
      View in: PubMed
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