Irina Rodionova

Title(s)Assistant Project Scientist, Bioengineering
SchoolAcademic Aff
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L. Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase. ACS Chem Biol. 2019 May 17; 14(5):949-958. PMID: 30969758.
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    2. Bouvier JT, Sernova NV, Ghasempur S, Rodionova IA, Vetting MW, Al-Obaidi NF, Almo SC, Gerlt JA, Rodionov DA. Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria. J Bacteriol. 2019 Jan 15; 201(2). PMID: 30249705.
      View in: PubMed
    3. Rodionova IA, Goodacre N, Do J, Hosseinnia A, Babu M, Uetz P, Saier MH. The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-?-glutamate synthase FolC. J Biol Chem. 2018 10 05; 293(40):15725-15732. PMID: 30089654.
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    4. Rodionova IA, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. J Bacteriol. 2018 03 01; 200(5). PMID: 29229699.
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    5. Rodionova IA, Zhang Z, Mehla J, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli. J Biol Chem. 2017 08 25; 292(34):14250-14257. PMID: 28634232.
      View in: PubMed
    6. Rodionova IA, Vetting MW, Li X, Almo SC, Osterman AL, Rodionov DA. A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea. Nucleic Acids Res. 2017 Apr 20; 45(7):3785-3799. PMID: 28073944.
      View in: PubMed
    7. Rodionov DA, Leyn SA, Li X, Rodionova IA. A Novel Transcriptional Regulator Related to Thiamine Phosphate Synthase Controls Thiamine Metabolism Genes in Archaea. J Bacteriol. 2017 02 15; 199(4). PMID: 27920295.
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    8. Romine MF, Rodionov DA, Maezato Y, Anderson LN, Nandhikonda P, Rodionova IA, Carre A, Li X, Xu C, Clauss TR, Kim YM, Metz TO, Wright AT. Elucidation of roles for vitamin B12 in regulation of folate, ubiquinone, and methionine metabolism. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):E1205-E1214. PMID: 28137868.
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    9. Zhang F, Patel DM, Colavita K, Rodionova I, Buckley B, Scott DA, Kumar A, Shabalina SA, Saha S, Chernov M, Osterman AL, Kashina A. Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. Nat Commun. 2015 Jul 15; 6:7517. PMID: 26175007; PMCID: PMC4503932.
    10. Leyn SA, Rodionova IA, Li X, Rodionov DA. Novel Transcriptional Regulons for Autotrophic Cycle Genes in Crenarchaeota. J Bacteriol. 2015 Jul; 197(14):2383-91. PMID: 25939834; PMCID: PMC4524184.
    11. Rodionova IA, Zuccola HJ, Sorci L, Aleshin AE, Kazanov MD, Ma CT, Sergienko E, Rubin EJ, Locher CP, Osterman AL. Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J Biol Chem. 2015 Mar 20; 290(12):7693-706. PMID: 25631047; PMCID: PMC4367272.
    12. Rodionova IA, Li X, Plymale AE, Motamedchaboki K, Konopka AE, Romine MF, Fredrickson JK, Osterman AL, Rodionov DA. Genomic distribution of B-vitamin auxotrophy and uptake transporters in environmental bacteria from the Chloroflexi phylum. Environ Microbiol Rep. 2015 Apr; 7(2):204-10. PMID: 25345570.
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    13. Rodionova IA, Schuster BM, Guinn KM, Sorci L, Scott DA, Li X, Kheterpal I, Shoen C, Cynamon M, Locher C, Rubin EJ, Osterman AL. Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria. MBio. 2014 Feb 18; 5(1). PMID: 24549842; PMCID: PMC3944813.
    14. Rodionova IA, Li X, Thiel V, Stolyar S, Stanton K, Fredrickson JK, Bryant DA, Osterman AL, Best AA, Rodionov DA. Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria. Front Microbiol. 2013; 4:407. PMID: 24391637; PMCID: PMC3870299.
    15. Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A, Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D, Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S. The COMBREX project: design, methodology, and initial results. PLoS Biol. 2013; 11(8):e1001638. PMID: 24013487; PMCID: PMC3754883.
    16. Rodionov DA, Rodionova IA, Li X, Ravcheev DA, Tarasova Y, Portnoy VA, Zengler K, Osterman AL. Transcriptional regulation of the carbohydrate utilization network in Thermotoga maritima. Front Microbiol. 2013; 4:244. PMID: 23986752; PMCID: PMC3750489.
    17. Rodionova IA, Leyn SA, Burkart MD, Boucher N, Noll KM, Osterman AL, Rodionov DA. Novel inositol catabolic pathway in Thermotoga maritima. Environ Microbiol. 2013 Aug; 15(8):2254-66. PMID: 23441918.
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    18. Sorci L, Blaby IK, Rodionova IA, De Ingeniis J, Tkachenko S, de Crécy-Lagard V, Osterman AL. Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci. J Bacteriol. 2013 Feb; 195(4):726-32. PMID: 23204464; PMCID: PMC3562111.
    19. Rodionova IA, Scott DA, Grishin NV, Osterman AL, Rodionov DA. Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima. Environ Microbiol. 2012 Nov; 14(11):2920-34. PMID: 22925190; PMCID: PMC4505799.
    20. Rodionova IA, Yang C, Li X, Kurnasov OV, Best AA, Osterman AL, Rodionov DA. Diversity and versatility of the Thermotoga maritima sugar kinome. J Bacteriol. 2012 Oct; 194(20):5552-63. PMID: 22885293; PMCID: PMC3458674.
    21. Zhang Y, Zagnitko O, Rodionova I, Osterman A, Godzik A. The FGGY carbohydrate kinase family: insights into the evolution of functional specificities. PLoS Comput Biol. 2011 Dec; 7(12):e1002318. PMID: 22215998; PMCID: PMC3245297.
    22. Johnson S, Barile E, Farina B, Purves A, Wei J, Chen LH, Shiryaev S, Zhang Z, Rodionova I, Agrawal A, Cohen SM, Osterman A, Strongin A, Pellecchia M. Targeting metalloproteins by fragment-based lead discovery. Chem Biol Drug Des. 2011 Aug; 78(2):211-23. PMID: 21564556; PMCID: PMC3135788.
    23. Rodionov DA, Novichkov PS, Stavrovskaya ED, Rodionova IA, Li X, Kazanov MD, Ravcheev DA, Gerasimova AV, Kazakov AE, Kovaleva GY, Permina EA, Laikova ON, Overbeek R, Romine MF, Fredrickson JK, Arkin AP, Dubchak I, Osterman AL, Gelfand MS. Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus. BMC Genomics. 2011 Jun 15; 12 Suppl 1:S3. PMID: 21810205; PMCID: PMC3223726.
    24. Rodionov DA, Yang C, Li X, Rodionova IA, Wang Y, Obraztsova AY, Zagnitko OP, Overbeek R, Romine MF, Reed S, Fredrickson JK, Nealson KH, Osterman AL. Genomic encyclopedia of sugar utilization pathways in the Shewanella genus. BMC Genomics. 2010 Sep 13; 11:494. PMID: 20836887; PMCID: PMC2996990.
    25. Huang N, Kolhatkar R, Eyobo Y, Sorci L, Rodionova I, Osterman AL, Mackerell AD, Zhang H. Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement. J Med Chem. 2010 Jul 22; 53(14):5229-39. PMID: 20578699; PMCID: PMC2915899.
    26. Sorci L, Pan Y, Eyobo Y, Rodionova I, Huang N, Kurnasov O, Zhong S, MacKerell AD, Zhang H, Osterman AL. Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Chem Biol. 2009 Aug 28; 16(8):849-61. PMID: 19716475.
      View in: PubMed
    27. Rodionov DA, Hebbeln P, Eudes A, ter Beek J, Rodionova IA, Erkens GB, Slotboom DJ, Gelfand MS, Osterman AL, Hanson AD, Eitinger T. A novel class of modular transporters for vitamins in prokaryotes. J Bacteriol. 2009 Jan; 191(1):42-51. PMID: 18931129; PMCID: PMC2612444.
    28. Rodionov DA, Li X, Rodionova IA, Yang C, Sorci L, Dervyn E, Martynowski D, Zhang H, Gelfand MS, Osterman AL. Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon. Nucleic Acids Res. 2008 Apr; 36(6):2032-46. PMID: 18276644; PMCID: PMC2330245.
    29. Yang C, Rodionov DA, Rodionova IA, Li X, Osterman AL. Glycerate 2-kinase of Thermotoga maritima and genomic reconstruction of related metabolic pathways. J Bacteriol. 2008 Mar; 190(5):1773-82. PMID: 18156253; PMCID: PMC2258669.