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Howard Rockman

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0613B
La Jolla CA 92093
Phone919-668-2520
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying Cardiomyopathy Genes in Mice and Drosophila
    NIH/NHLBI R01HL083065Dec 1, 2005 - Aug 31, 2015
    Role: Principal Investigator
    Novel Mechanisms and Therapies in Heart Failure
    NIH/NHLBI P01HL075443Sep 10, 2004 - May 31, 2020
    Role: Principal Investigator
    Modifier Genes in Heart Failure
    NIH/NHLBI R01HL068963Sep 30, 2001 - Jun 30, 2007
    Role: Principal Investigator
    Genes That Regulate Target Organ Damage in Hypertension
    NIH/NHLBI R01HL069230Sep 30, 2001 - Aug 31, 2006
    Role: Principal Investigator
    PHENOTYPIC SCREENS FOR CARDIOVASCULAR MUTATIONS IN MICE
    NIH/NHLBI R01HL065184Sep 30, 2000 - Jul 31, 2004
    Role: Principal Investigator
    Regulation of beta AR Function by P13K Inhibition
    NIH/NHLBI R01HL061558Jan 11, 1999 - Aug 31, 2004
    Role: Principal Investigator
    Mechanisms of Maladaptation in Heart Failure
    NIH/NHLBI R01HL056687Aug 1, 1996 - Apr 30, 2019
    Role: Principal Investigator
    SR CA++ ATPASE TRANSGENE OVEREXPRESSION IN FAILING HEART
    NIH/NHLBI K08HL003041Aug 1, 1994 - Jul 31, 1999
    Role: Principal Investigator
    Multidisciplinary Heart and Vascular Diseases
    NIH/NHLBI T32HL007101Jul 1, 1975 - Mar 31, 2021
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wisler JW, Rockman H, Lefkowitz RJ. Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery. Circulation. 2018 May 29; 137(22):2315-2317. PMID: 29844068.
      View in: PubMed
    2. Rockman H. We're listening. JCI Insight. 2018 Jan 25; 3(2). PMID: 29367456.
      View in: PubMed
    3. Wang J, Hanada K, Gareri C, Rockman H. Mechanoactivation of the angiotensin II type 1 receptor induces ß-arrestin-biased signaling through Gai coupling. J Cell Biochem. 2018 Apr; 119(4):3586-3597. PMID: 29231251.
      View in: PubMed
    4. Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman H. Gai is required for carvedilol-induced ß1 adrenergic receptor ß-arrestin biased signaling. Nat Commun. 2017 Nov 22; 8(1):1706. PMID: 29167435.
      View in: PubMed
    5. Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman H, Shenoy SK. Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of ß-adrenergic receptor signaling. JCI Insight. 2017 Sep 07; 2(17). PMID: 28878120.
      View in: PubMed
    6. Rockman H. ?????? ??????. J Clin Invest. 2017 Jun 01; 127(6):2019-2020. PMID: 28569731.
      View in: PubMed
    7. Rockman H. A successful launch. JCI Insight. 2017 Jan 26; 2(2):e92800. PMID: 28138566.
      View in: PubMed
    8. Abraham DM, Davis RT, Warren CM, Mao L, Wolska BM, Solaro RJ, Rockman H. ß-Arrestin mediates the Frank-Starling mechanism of cardiac contractility. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14426-14431. PMID: 27911784.
      View in: PubMed
    9. Watson LJ, Alexander KM, Mohan ML, Bowman AL, Mangmool S, Xiao K, Naga Prasad SV, Rockman H. Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. Cell Signal. 2016 10; 28(10):1580-92. PMID: 27169346; PMCID: PMC4980165 [Available on 10/01/17].
    10. Hodavance SY, Gareri C, Torok RD, Rockman H. G Protein-coupled Receptor Biased Agonism. J Cardiovasc Pharmacol. 2016 Mar; 67(3):193-202. PMID: 26751266; PMCID: PMC4783281 [Available on 03/01/17].
    11. Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman H, Van Eyk JE, Craig R, Farazi TG, Kass DA. Pacemaker-induced transient asynchrony suppresses heart failure progression. Sci Transl Med. 2015 Dec 23; 7(319):319ra207. PMID: 26702095; PMCID: PMC4858435.
    12. Xu W, Barrientos T, Mao L, Rockman H, Sauve AA, Andrews NC. Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. Cell Rep. 2015 Oct 20; 13(3):533-545. PMID: 26456827; PMCID: PMC4618069.
    13. Wisler JW, Harris EM, Raisch M, Mao L, Kim J, Rockman H, Lefkowitz RJ. The role of ß-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. Am J Physiol Heart Circ Physiol. 2015 Nov; 309(9):H1516-27. PMID: 26371162; PMCID: PMC4666970.
    14. Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman H. Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. Circulation. 2015 Jun 16; 131(24):2120-30. PMID: 25995315; PMCID: PMC4470842.
    15. Rockman H. Happy birthday JCI. J Clin Invest. 2014 Oct; 124(10):4135-6. PMID: 25271720; PMCID: PMC4191037.
    16. Tang W, Strachan RT, Lefkowitz RJ, Rockman H. Allosteric modulation of ß-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. J Biol Chem. 2014 Oct 10; 289(41):28271-83. PMID: 25170081; PMCID: PMC4192482.
    17. Lee TE, Yu L, Wolf MJ, Rockman H. Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila. Genetics. 2014 Oct; 198(2):591-603. PMID: 25081566; PMCID: PMC4196615.
    18. Ashton JR, Befera N, Clark D, Qi Y, Mao L, Rockman H, Johnson GA, Badea CT. Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. Contrast Media Mol Imaging. 2014 Mar-Apr; 9(2):161-8. PMID: 24523061; PMCID: PMC4017375.
    19. Rockman H. Waste not, want not. J Clin Invest. 2014 Feb; 124(2):463. PMID: 24487638; PMCID: PMC3904639.
    20. Kim IM, Wang Y, Park KM, Tang Y, Teoh JP, Vinson J, Traynham CJ, Pironti G, Mao L, Su H, Johnson JA, Koch WJ, Rockman H. ß-arrestin1-biased ß1-adrenergic receptor signaling regulates microRNA processing. Circ Res. 2014 Feb 28; 114(5):833-44. PMID: 24334028; PMCID: PMC3955054.
    21. Santacruz L, Hernandez A, Nienaber J, Mishra R, Pinilla M, Burchette J, Mao L, Rockman H, Jacobs DO. Normal cardiac function in mice with supraphysiological cardiac creatine levels. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H373-81. PMID: 24271489; PMCID: PMC3920135.
    22. Tang H, Xiao K, Mao L, Rockman H, Marchuk DA. Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction. J Mol Cell Cardiol. 2013 Jan; 54:101-11. PMID: 23085512.
      View in: PubMed
    23. Kim KS, Abraham D, Williams B, Violin JD, Mao L, Rockman H. ß-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. Am J Physiol Heart Circ Physiol. 2012 Oct 15; 303(8):H1001-10. PMID: 22886417; PMCID: PMC3469643.
    24. Lee CL, Moding EJ, Cuneo KC, Li Y, Sullivan JM, Mao L, Washington I, Jeffords LB, Rodrigues RC, Ma Y, Das S, Kontos CD, Kim Y, Rockman H, Kirsch DG. p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. Sci Signal. 2012 Jul 24; 5(234):ra52. PMID: 22827996; PMCID: PMC3533440.
    25. Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman H, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W. Animal models of heart failure: a scientific statement from the American Heart Association. Circ Res. 2012 Jun 22; 111(1):131-50. PMID: 22595296.
      View in: PubMed
    26. Rockman H. Great expectations. J Clin Invest. 2012 Apr; 122(4):1133. PMID: 22466653; PMCID: PMC3314484.
    27. Casad ME, Yu L, Daniels JP, Wolf MJ, Rockman H. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Mol Genet Genomics. 2012 Apr; 287(4):351-60. PMID: 22398840; PMCID: PMC3701947.
    28. Rockman H. Tradition, tradition. J Clin Invest. 2012 Mar; 122(3):785-6. PMID: 22378046; PMCID: PMC3287243.
    29. Caplan AL, Rockman H, Turka LA. Editorial position on publishing articles on human organ transplantation. J Clin Invest. 2012 Jan; 122(1):2. PMID: 22214852; PMCID: PMC3248316.
    30. Shenoy SK, Rockman H. Cardiovascular biology: heart fails without pump partner. Nature. 2011 Sep 28; 477(7366):546-7. PMID: 21956327.
      View in: PubMed
    31. Wolf MJ, Rockman H. Drosophila, genetic screens, and cardiac function. Circ Res. 2011 Sep 16; 109(7):794-806. PMID: 21921272; PMCID: PMC3678974.
    32. Casad ME, Abraham D, Kim IM, Frangakis S, Dong B, Lin N, Wolf MJ, Rockman H. Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. Genetics. 2011 Nov; 189(3):861-70. PMID: 21890737; PMCID: PMC3213377.
    33. Rockman H, Lefkowitz RJ. Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling. Circ Res. 2011 Jul 08; 109(2):202-4. PMID: 21737815; PMCID: PMC3298859.
    34. Lin N, Badie N, Yu L, Abraham D, Cheng H, Bursac N, Rockman H, Wolf MJ. A method to measure myocardial calcium handling in adult Drosophila. Circ Res. 2011 May 27; 108(11):1306-15. PMID: 21493892; PMCID: PMC3128985.
    35. Grotegut CA, Feng L, Mao L, Heine RP, Murtha AP, Rockman H. ß-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration. Am J Physiol Endocrinol Metab. 2011 Mar; 300(3):E468-77. PMID: 21139074; PMCID: PMC3064008.
    36. Noor N, Patel CB, Rockman H. ?-arrestin: a signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):534-41. PMID: 21074538; PMCID: PMC3063861.
    37. Patel CB, Noor N, Rockman H. Functional selectivity in adrenergic and angiotensin signaling systems. Mol Pharmacol. 2010 Dec; 78(6):983-92. PMID: 20855464; PMCID: PMC2993470.
    38. Rakesh K, Yoo B, Kim IM, Salazar N, Kim KS, Rockman H. beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci Signal. 2010 Jun 08; 3(125):ra46. PMID: 20530803; PMCID: PMC2981501.
    39. Tilley DG, Nguyen AD, Rockman H. Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor. Biochem Biophys Res Commun. 2010 Jun 11; 396(4):921-6. PMID: 20460106; PMCID: PMC2907067.
    40. Kim BE, Turski ML, Nose Y, Casad M, Rockman H, Thiele DJ. Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Cell Metab. 2010 May 05; 11(5):353-63. PMID: 20444417; PMCID: PMC2901851.
    41. Mangmool S, Shukla AK, Rockman H. beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol. 2010 May 03; 189(3):573-87. PMID: 20421423; PMCID: PMC2867304.
    42. Bucholz E, Ghaghada K, Qi Y, Mukundan S, Rockman H, Johnson GA. Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. Magn Reson Med. 2010 Apr; 63(4):979-87. PMID: 20373399; PMCID: PMC2852272.
    43. Kim IM, Wolf MJ, Rockman H. Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res. 2010 Apr 16; 106(7):1233-43. PMID: 20203305; PMCID: PMC2860286.
    44. Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman H, Birnbaumer L, Rosenberg P. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res. 2009 Nov 06; 105(10):1023-30. PMID: 19797170; PMCID: PMC2881555.
    45. Wheeler FC, Tang H, Marks OA, Hadnott TN, Chu PL, Mao L, Rockman H, Marchuk DA. Tnni3k modifies disease progression in murine models of cardiomyopathy. PLoS Genet. 2009 Sep; 5(9):e1000647. PMID: 19763165; PMCID: PMC2731170.
    46. Yoo B, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman H. Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1377-86. PMID: 19633206; PMCID: PMC2770777.
    47. Pandya K, Porter K, Rockman H, Smithies O. Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. Eur J Heart Fail. 2009 Jul; 11(7):648-52. PMID: 19553396; PMCID: PMC2701279.
    48. Tilley DG, Kim IM, Patel PA, Violin JD, Rockman H. beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. J Biol Chem. 2009 Jul 24; 284(30):20375-86. PMID: 19509284; PMCID: PMC2740462.
    49. Fernandez L, Marchuk DA, Moran JL, Beier DR, Rockman H. An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. Mamm Genome. 2009 May; 20(5):296-304. PMID: 19387734; PMCID: PMC2743897.
    50. Lima B, Lam GK, Xie L, Diesen DL, Villamizar N, Nienaber J, Messina E, Bowles D, Kontos CD, Hare JM, Stamler JS, Rockman H. Endogenous S-nitrosothiols protect against myocardial injury. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6297-302. PMID: 19325130; PMCID: PMC2669330.
    51. Mehra MR, Rockman H, Greenberg BH. Highlights of the 2008 Scientific Sessions of the Heart Failure Society of America. Toronto, Ontario, Canada, September 20-23, 2008. J Am Coll Cardiol. 2009 Feb 10; 53(6):514-22. PMID: 19195609.
      View in: PubMed
    52. Acehan D, Khuchua Z, Houtkooper RH, Malhotra A, Kaufman J, Vaz FM, Ren M, Rockman H, Stokes DL, Schlame M. Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion. 2009 Apr; 9(2):86-95. PMID: 19114128; PMCID: PMC2660382.
    53. Patel PA, Tilley DG, Rockman H. Physiologic and cardiac roles of beta-arrestins. J Mol Cell Cardiol. 2009 Mar; 46(3):300-8. PMID: 19103204.
      View in: PubMed
    54. Patel PA, Tilley DG, Rockman H. Beta-arrestin-mediated signaling in the heart. Circ J. 2008 Nov; 72(11):1725-9. PMID: 18838825; PMCID: PMC2617733.
    55. Wolf MJ, Rockman H. Drosophila melanogaster as a model system for genetics of postnatal cardiac function. Drug Discov Today Dis Models. 2008 Oct 01; 5(3):117-123. PMID: 19802348.
      View in: PubMed
    56. Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman H. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14555-60. PMID: 18787115; PMCID: PMC2567217.
    57. Pandya K, Cowhig J, Brackhan J, Kim HS, Hagaman J, Rojas M, Carter CW, Mao L, Rockman H, Maeda N, Smithies O. Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13063-8. PMID: 18755891; PMCID: PMC2526551.
    58. Francois H, Makhanova N, Ruiz P, Ellison J, Mao L, Rockman H, Coffman TM. A role for the thromboxane receptor in L-NAME hypertension. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1096-102. PMID: 18684890; PMCID: PMC2576155.
    59. Ream MA, Chandra R, Peavey M, Ray AM, Roffler-Tarlov S, Kim HG, Wetsel WC, Rockman H, Chikaraishi DM. High oxygen prevents fetal lethality due to lack of catecholamines. Am J Physiol Regul Integr Comp Physiol. 2008 Sep; 295(3):R942-53. PMID: 18635452; PMCID: PMC2536863.
    60. Barki-Harrington L, Rockman H. Beta-arrestins: multifunctional cellular mediators. Physiology (Bethesda). 2008 Feb; 23:17-22. PMID: 18268361.
      View in: PubMed
    61. Mehra MR, Rockman H, Greenberg BH. Highlights of the 2007 Scientific Meeting of the Heart Failure Society of America: Washington, DC, September 16-19, 2007. J Am Coll Cardiol. 2008 Jan 22; 51(3):320-7. PMID: 18206743.
      View in: PubMed
    62. Esposito G, Perrino C, Ozaki T, Takaoka H, Defer N, Petretta MP, De Angelis MC, Mao L, Hanoune J, Rockman H, Chiariello M. Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8. Basic Res Cardiol. 2008 Jan; 103(1):22-30. PMID: 18034275.
      View in: PubMed
    63. Chin BB, Metzler SD, Lemaire A, Curcio A, Vemulapalli S, Greer KL, Petry NA, Turkington TG, Coleman RE, Rockman H, Jaszczak RJ. Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT. Radiology. 2007 Nov; 245(2):440-8. PMID: 17940303.
      View in: PubMed
    64. Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman H, Bennett V. Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. PLoS One. 2007 Oct 17; 2(10):e1051. PMID: 17940615; PMCID: PMC2013943.
    65. Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman H, McNally EM. Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum Mol Genet. 2007 Dec 01; 16(23):2933-43. PMID: 17855453.
      View in: PubMed
    66. Salzler HR, Griffiths R, Ruiz P, Chi L, Frey C, Marchuk DA, Rockman H, Le TH. Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus. Kidney Int. 2007 Nov; 72(10):1226-32. PMID: 17851470.
      View in: PubMed
    67. Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman H. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest. 2007 Sep; 117(9):2445-58. PMID: 17786238; PMCID: PMC1952636.
    68. Perrino C, Rockman H. Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure. Curr Opin Cardiol. 2007 Sep; 22(5):443-9. PMID: 17762546.
      View in: PubMed
    69. Badea CT, Hedlund LW, Mackel JF, Mao L, Rockman H, Johnson GA. Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. Mol Imaging. 2007 Jul-Aug; 6(4):261-8. PMID: 17711781; PMCID: PMC2671027.
    70. Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman H, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007 May 04; 129(3):511-22. PMID: 17482545.
      View in: PubMed
    71. Salazar NC, Chen J, Rockman H. Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta. 2007 Apr; 1768(4):1006-18. PMID: 17376402; PMCID: PMC1892229.
    72. Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman H, Lefkowitz RJ. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16284-9. PMID: 17060617; PMCID: PMC1637574.
    73. Donahue MP, Marchuk DA, Rockman H. Redefining heart failure: the utility of genomics. J Am Coll Cardiol. 2006 Oct 03; 48(7):1289-98. PMID: 17010784.
      View in: PubMed
    74. Gurley SB, Allred A, Le TH, Griffiths R, Mao L, Philip N, Haystead TA, Donoghue M, Breitbart RE, Acton SL, Rockman H, Coffman TM. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug; 116(8):2218-25. PMID: 16878172; PMCID: PMC1518789.
    75. Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman H, Murphy E, Zeldin DC. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res. 2006 Aug 18; 99(4):442-50. PMID: 16857962.
      View in: PubMed
    76. Perrino C, Rockman H, Chiariello M. Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure. Vascul Pharmacol. 2006 Aug; 45(2):77-85. PMID: 16807128.
      View in: PubMed
    77. Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS, Smithies O, Rockman H. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest. 2006 Jun; 116(6):1547-60. PMID: 16741575; PMCID: PMC1464895.
    78. Curcio A, Noma T, Naga Prasad SV, Wolf MJ, Lemaire A, Perrino C, Mao L, Rockman H. Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1754-60. PMID: 16699071.
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    79. Tilley DG, Rockman H. Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment. Expert Rev Cardiovasc Ther. 2006 May; 4(3):417-32. PMID: 16716102.
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    80. Perrino C, Rockman H. GATA4 and the two sides of gene expression reprogramming. Circ Res. 2006 Mar 31; 98(6):715-6. PMID: 16574910.
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    81. Tachibana H, Perrino C, Takaoka H, Davis RJ, Naga Prasad SV, Rockman H. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun. 2006 May 19; 343(4):1060-6. PMID: 16579967.
      View in: PubMed
    82. Volovyk ZM, Wolf MJ, Prasad SV, Rockman H. Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover. J Biol Chem. 2006 Apr 07; 281(14):9773-80. PMID: 16461348.
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    83. Wolf MJ, Amrein H, Izatt JA, Choma MA, Reedy MC, Rockman H. Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1394-9. PMID: 16432241; PMCID: PMC1360529.
    84. Badea CT, Bucholz E, Hedlund LW, Rockman H, Johnson GA. Imaging methods for morphological and functional phenotyping of the rodent heart. Toxicol Pathol. 2006; 34(1):111-7. PMID: 16507552.
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    85. Rajagopal K, Lefkowitz RJ, Rockman H. When 7 transmembrane receptors are not G protein-coupled receptors. J Clin Invest. 2005 Nov; 115(11):2971-4. PMID: 16276410; PMCID: PMC1265881.
    86. Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim HS, Rockman H, Fitzgerald GA, Koller BH, Coffman TM. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab. 2005 Sep; 2(3):201-7. PMID: 16154102.
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    87. Perrino C, Esposito G, Rockman H. Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med. 2005 Sep; 47(3):143-55. PMID: 16462723.
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    88. Chen Z, Foster MW, Zhang J, Mao L, Rockman H, Kawamoto T, Kitagawa K, Nakayama KI, Hess DT, Stamler JS. An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12159-64. PMID: 16103363; PMCID: PMC1189320.
    89. Naga Prasad SV, Jayatilleke A, Madamanchi A, Rockman H. Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. Nat Cell Biol. 2005 Aug; 7(8):785-96. PMID: 16094730.
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    90. Perrino C, Naga Prasad SV, Patel M, Wolf MJ, Rockman H. Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. J Am Coll Cardiol. 2005 Jun 07; 45(11):1862-70. PMID: 15936620.
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    91. Wheeler FC, Fernandez L, Carlson KM, Wolf MJ, Rockman H, Marchuk DA. QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. Mamm Genome. 2005 Jun; 16(6):414-23. PMID: 16075368.
      View in: PubMed
    92. Perrino C, Naga Prasad SV, Schroder JN, Hata JA, Milano C, Rockman H. Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. Circulation. 2005 May 24; 111(20):2579-87. PMID: 15897344.
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    93. van den Bosch BJ, van den Burg CM, Schoonderwoerd K, Lindsey PJ, Scholte HR, de Coo RF, van Rooij E, Rockman H, Doevendans PA, Smeets HJ. Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice. Cardiovasc Res. 2005 Feb 01; 65(2):411-8. PMID: 15639480.
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    94. Tachibana H, Naga Prasad SV, Lefkowitz RJ, Koch WJ, Rockman H. Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation. 2005 Feb 08; 111(5):591-7. PMID: 15668342.
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    95. Wolf MJ, Tachibana H, Rockman H. Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts. Methods Mol Med. 2005; 112:353-62. PMID: 16010029.
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    96. Kedar V, McDonough H, Arya R, Li HH, Rockman H, Patterson C. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18135-40. PMID: 15601779; PMCID: PMC539735.
    97. Nassar R, Malouf NN, Mao L, Rockman H, Oakeley AE, Frye JR, Herlong JR, Sanders SP, Anderson PA. cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1147-56. PMID: 15513965.
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    98. Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman H, Guo Y, Bolli R, Glembotski CC. Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. J Biol Chem. 2005 Jan 07; 280(1):669-76. PMID: 15492008; PMCID: PMC3691679.
    99. Skavdahl M, Steenbergen C, Clark J, Myers P, Demianenko T, Mao L, Rockman H, Korach KS, Murphy E. Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol. 2005 Feb; 288(2):H469-76. PMID: 15374829.
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    100. Barki-Harrington L, Perrino C, Rockman H. Network integration of the adrenergic system in cardiac hypertrophy. Cardiovasc Res. 2004 Aug 15; 63(3):391-402. PMID: 15276464.
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    101. Seubert J, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman J, Mao L, Rockman H, Hammock BD, Murphy E, Zeldin DC. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res. 2004 Sep 03; 95(5):506-14. PMID: 15256482.
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    102. Tong H, Rockman H, Koch WJ, Steenbergen C, Murphy E. G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. Circ Res. 2004 Apr 30; 94(8):1133-41. PMID: 15031261.
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    103. Caron KM, James LR, Kim HS, Knowles J, Uhlir R, Mao L, Hagaman JR, Cascio W, Rockman H, Smithies O. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3106-11. PMID: 14978280; PMCID: PMC365751.
    104. Francois H, Athirakul K, Mao L, Rockman H, Coffman TM. Role for thromboxane receptors in angiotensin-II-induced hypertension. Hypertension. 2004 Feb; 43(2):364-9. PMID: 14718360.
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    105. Blaxall BC, Spang R, Rockman H, Koch WJ. Differential myocardial gene expression in the development and rescue of murine heart failure. Physiol Genomics. 2003 Oct 17; 15(2):105-14. PMID: 12865503.
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    106. Nienaber JJ, Tachibana H, Naga Prasad SV, Esposito G, Wu D, Mao L, Rockman H. Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest. 2003 Oct; 112(7):1067-79. PMID: 14523044; PMCID: PMC198526.
    107. Le Corvoisier P, Park HY, Carlson KM, Marchuk DA, Rockman H. Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy. Hum Mol Genet. 2003 Dec 01; 12(23):3097-107. PMID: 14519689.
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    108. Barki-Harrington L, Luttrell LM, Rockman H. Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. Circulation. 2003 Sep 30; 108(13):1611-8. PMID: 12963634.
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    109. Keys JR, Greene EA, Cooper CJ, Naga Prasad SV, Rockman H, Koch WJ. Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H2201-11. PMID: 12869383.
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    110. Naga Prasad SV, Perrino C, Rockman H. Role of phosphoinositide 3-kinase in cardiac function and heart failure. Trends Cardiovasc Med. 2003 Jul; 13(5):206-12. PMID: 12837584.
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    111. Rapacciuolo A, Suvarna S, Barki-Harrington L, Luttrell LM, Cong M, Lefkowitz RJ, Rockman H. Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. J Biol Chem. 2003 Sep 12; 278(37):35403-11. PMID: 12821660.
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    112. Most P, Remppis A, Pleger ST, Löffler E, Ehlermann P, Bernotat J, Kleuss C, Heierhorst J, Ruiz P, Witt H, Karczewski P, Mao L, Rockman H, Duncan SJ, Katus HA, Koch WJ. Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. J Biol Chem. 2003 Sep 05; 278(36):33809-17. PMID: 12777394.
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    113. Le Corvoisier P, Park HY, Rockman H. Modifier genes and heart failure. Minerva Cardioangiol. 2003 Apr; 51(2):107-20. PMID: 12783067.
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    114. Le Corvoisier P, Park HY, Carlson KM, Donahue MP, Marchuk DA, Rockman H. Impact of genetic polymorphisms on heart failure prognosis. Arch Mal Coeur Vaiss. 2003 Mar; 96(3):197-206. PMID: 12722550.
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    115. Colomer JM, Mao L, Rockman H, Means AR. Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Mol Endocrinol. 2003 Feb; 17(2):183-92. PMID: 12554746.
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    116. Barki-Harrington L, Rockman H. Sensing heart stress. Nat Med. 2003 Jan; 9(1):19-20. PMID: 12514714.
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    117. Esposito G, Rapacciuolo A, Naga Prasad SV, Rockman H. Cardiac hypertrophy: role of G protein-coupled receptors. J Card Fail. 2002 Dec; 8(6 Suppl):S409-14. PMID: 12555153.
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    118. Naga Prasad SV, Laporte SA, Chamberlain D, Caron MG, Barak L, Rockman H. Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol. 2002 Aug 05; 158(3):563-75. PMID: 12163475; PMCID: PMC2173831.
    119. Takaoka H, Esposito G, Mao L, Suga H, Rockman H. Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2190-7. PMID: 12003828.
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    120. Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman H, Koch WJ, Luttrell LM. Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. J Biol Chem. 2002 Aug 09; 277(32):28631-40. PMID: 12036966.
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    121. Suzuki M, Carlson KM, Marchuk DA, Rockman H. Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. Circulation. 2002 Apr 16; 105(15):1824-9. PMID: 11956126.
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    122. Eckhart AD, Ozaki T, Tevaearai H, Rockman H, Koch WJ. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol. 2002 Apr; 61(4):749-58. PMID: 11901213.
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    123. Rockman H, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature. 2002 Jan 10; 415(6868):206-12. PMID: 11805844.
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    124. Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, Rockman H. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation. 2002 Jan 01; 105(1):85-92. PMID: 11772881.
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    125. Prasad SV, Nienaber J, Rockman H. G-protein-coupled receptor function in heart failure. Cold Spring Harb Symp Quant Biol. 2002; 67:439-44. PMID: 12858569.
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    126. Kohout TA, Takaoka H, McDonald PH, Perry SJ, Mao L, Lefkowitz RJ, Rockman H. Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. Circulation. 2001 Nov 13; 104(20):2485-91. PMID: 11705829.
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    127. Naga Prasad SV, Nienaber J, Rockman H. Beta-adrenergic axis and heart disease. Trends Genet. 2001 Oct; 17(10):S44-9. PMID: 11585676.
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    128. Rapacciuolo A, Esposito G, Prasad SV, Rockman H. G protein-coupled receptor signalling in in vivo cardiac overload. Acta Physiol Scand. 2001 Sep; 173(1):51-7. PMID: 11678726.
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    129. Rapacciuolo A, Esposito G, Caron K, Mao L, Thomas SA, Rockman H. Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy. J Am Coll Cardiol. 2001 Sep; 38(3):876-82. PMID: 11527648.
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    130. Iaccarino G, Keys JR, Rapacciuolo A, Shotwell KF, Lefkowitz RJ, Rockman H, Koch WJ. Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. J Am Coll Cardiol. 2001 Aug; 38(2):534-40. PMID: 11499749.
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    131. Ufret-Vincenty CA, Baro DJ, Lederer WJ, Rockman H, Quinones LE, Santana LF. Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. J Biol Chem. 2001 Jul 27; 276(30):28197-203. PMID: 11369778.
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    132. Harding VB, Jones LR, Lefkowitz RJ, Koch WJ, Rockman H. Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5809-14. PMID: 11331748; PMCID: PMC33295.
    133. Knowles JW, Esposito G, Mao L, Hagaman JR, Fox JE, Smithies O, Rockman H, Maeda N. Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest. 2001 Apr; 107(8):975-84. PMID: 11306601; PMCID: PMC199554.
    134. Naga Prasad SV, Barak LS, Rapacciuolo A, Caron MG, Rockman H. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. J Biol Chem. 2001 Jun 01; 276(22):18953-9. PMID: 11259422.
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    135. Esposito G, Prasad SV, Rapacciuolo A, Mao L, Koch WJ, Rockman H. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation. 2001 Mar 13; 103(10):1453-8. PMID: 11245652.
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    136. Esposito G, Santana LF, Dilly K, Cruz JD, Mao L, Lederer WJ, Rockman H. Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H3101-12. PMID: 11087268.
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    137. Manning BS, Shotwell K, Mao L, Rockman H, Koch WJ. Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy. Circulation. 2000 Nov 28; 102(22):2751-7. PMID: 11094043.
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    138. Brewis N, Ohst K, Fields K, Rapacciuolo A, Chou D, Bloor C, Dillmann W, Rockman H, Walter G. Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1307-18. PMID: 10993798.
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    139. Lipskaia L, Defer N, Esposito G, Hajar I, Garel MC, Rockman H, Hanoune J. Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. Circ Res. 2000 Apr 14; 86(7):795-801. PMID: 10764414.
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    140. Lefkowitz RJ, Rockman H, Koch WJ. Catecholamines, cardiac beta-adrenergic receptors, and heart failure. Circulation. 2000 Apr 11; 101(14):1634-7. PMID: 10758041.
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    141. Naga Prasad SV, Esposito G, Mao L, Koch WJ, Rockman H. Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. J Biol Chem. 2000 Feb 18; 275(7):4693-8. PMID: 10671499.
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    142. Koch WJ, Lefkowitz RJ, Rockman H. Functional consequences of altering myocardial adrenergic receptor signaling. Annu Rev Physiol. 2000; 62:237-60. PMID: 10845091.
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    143. Akhter SA, Eckhart AD, Rockman H, Shotwell K, Lefkowitz RJ, Koch WJ. In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation. 1999 Aug 10; 100(6):648-53. PMID: 10441103.
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    144. Cho MC, Rapacciuolo A, Koch WJ, Kobayashi Y, Jones LR, Rockman H. Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. J Biol Chem. 1999 Aug 06; 274(32):22251-6. PMID: 10428792.
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    145. Cho MC, Rao M, Koch WJ, Thomas SA, Palmiter RD, Rockman H. Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. Circulation. 1999 May 25; 99(20):2702-7. PMID: 10338466.
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    146. Koch WJ, Rockman H. Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. Trends Cardiovasc Med. 1999 Apr-May; 9(3-4):77-81. PMID: 10578521.
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    147. Choi DJ, Rockman H. Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure. Cell Biochem Biophys. 1999; 31(3):321-9. PMID: 10736754.
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    148. Iaccarino G, Rockman H, Shotwell KF, Tomhave ED, Koch WJ. Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. Am J Physiol. 1998 Oct; 275(4 Pt 2):H1298-306. PMID: 9746479.
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    149. Neumann J, Boknik P, DePaoli-Roach AA, Field LJ, Rockman H, Kobayashi YM, Kelley JS, Jones LR. Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. J Mol Cell Cardiol. 1998 Oct; 30(10):1991-2002. PMID: 9799653.
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    150. Tanaka N, Ryoke T, Hongo M, Mao L, Rockman H, Clark RG, Ross J. Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice. Am J Physiol. 1998 Aug; 275(2 Pt 2):H393-9. PMID: 9683425.
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    151. Rockman H, Choi DJ, Akhter SA, Jaber M, Giros B, Lefkowitz RJ, Caron MG, Koch WJ. Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. J Biol Chem. 1998 Jul 17; 273(29):18180-4. PMID: 9660778.
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    152. Rockman H, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7000-5. PMID: 9618528; PMCID: PMC22717.
    153. Akhter SA, Luttrell LM, Rockman H, Iaccarino G, Lefkowitz RJ, Koch WJ. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science. 1998 Apr 24; 280(5363):574-7. PMID: 9554846.
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    154. Koch WJ, Lefkowitz RJ, Milano CA, Akhter SA, Rockman H. Myocardial overexpression of adrenergic receptors and receptor kinases. Adv Pharmacol. 1998; 42:502-6. PMID: 9327950.
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    155. Oliver PM, Fox JE, Kim R, Rockman H, Kim HS, Reddick RL, Pandey KN, Milgram SL, Smithies O, Maeda N. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14730-5. PMID: 9405681; PMCID: PMC25105.
    156. Akhter SA, Milano CA, Shotwell KF, Cho MC, Rockman H, Lefkowitz RJ, Koch WJ. Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. J Biol Chem. 1997 Aug 22; 272(34):21253-9. PMID: 9261135.
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    157. He H, Giordano FJ, Hilal-Dandan R, Choi DJ, Rockman H, McDonough PM, Bluhm WF, Meyer M, Sayen MR, Swanson E, Dillmann WH. Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J Clin Invest. 1997 Jul 15; 100(2):380-9. PMID: 9218515; PMCID: PMC508201.
    158. Choi DJ, Koch WJ, Hunter JJ, Rockman H. Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. J Biol Chem. 1997 Jul 04; 272(27):17223-9. PMID: 9202046.
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    159. Sack MN, Disch DL, Rockman H, Kelly DP. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6438-43. PMID: 9177236; PMCID: PMC21068.
    160. Rockman H, Koch WJ, Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol. 1997 Apr; 272(4 Pt 2):H1553-9. PMID: 9139936.
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    161. Ryu KH, Tanaka N, Dalton N, Mao L, Rockman H, Milano CA, Ross J. Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation. J Card Fail. 1997 Mar; 3(1):27-39. PMID: 9110253.
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    162. Samama P, Bond RA, Rockman H, Milano CA, Lefkowitz RJ. Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):137-41. PMID: 8990174; PMCID: PMC19258.
    163. Rockman H. Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice. Adv Exp Med Biol. 1997; 430:67-72. PMID: 9330719.
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    164. Lembo G, Rockman H, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Chien KR, Powell-Braxton L. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest. 1996 Dec 01; 98(11):2648-55. PMID: 8958230; PMCID: PMC507725.
    165. Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK, Ross J, Lefkowitz RJ, Caron MG, Giros B. Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12974-9. PMID: 8917529; PMCID: PMC24031.
    166. Rockman H, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, Koch WJ. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9954-9. PMID: 8790438; PMCID: PMC38536.
    167. Tanaka N, Dalton N, Mao L, Rockman H, Peterson KL, Gottshall KR, Hunter JJ, Chien KR, Ross J. Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation. 1996 Sep 01; 94(5):1109-17. PMID: 8790053.
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    168. Rockman H, Koch WJ, Milano CA, Lefkowitz RJ. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. J Mol Med (Berl). 1996 Sep; 74(9):489-95. PMID: 8892053.
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    169. Swertfeger DK, Witte DP, Stuart WD, Rockman H, Harmony JA. Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury. Am J Pathol. 1996 Jun; 148(6):1971-83. PMID: 8669482; PMCID: PMC1861654.
    170. Rockman H, Hamilton RA, Jones LR, Milano CA, Mao L, Lefkowitz RJ. Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. J Clin Invest. 1996 Apr 01; 97(7):1618-23. PMID: 8601626; PMCID: PMC507225.
    171. Ben-Yehuda O, Rockman H. Regulation of myocardial contractility: Insights from transgenic mice. Trends Cardiovasc Med. 1996 Apr; 6(3):95-9. PMID: 21232281.
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    172. Hunter JJ, Tanaka N, Rockman H, Ross J, Chien KR. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem. 1995 Sep 29; 270(39):23173-8. PMID: 7559464.
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    173. Knowlton KU, Rockman H, Itani M, Vovan A, Seidman CE, Chien KR. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest. 1995 Sep; 96(3):1311-8. PMID: 7657806; PMCID: PMC185753.
    174. Lin MC, Rockman H, Chien KR. Heart and lung disease in engineered mice. Nat Med. 1995 Aug; 1(8):749-51. PMID: 7585174.
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    175. Koch WJ, Rockman H, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995 Jun 02; 268(5215):1350-3. PMID: 7761854.
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    176. Bond RA, Leff P, Johnson TD, Milano CA, Rockman H, McMinn TR, Apparsundaram S, Hyek MF, Kenakin TP, Allen LF. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature. 1995 Mar 16; 374(6519):272-6. PMID: 7885448.
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    177. Milano CA, Allen LF, Dolber PC, Johnson TD, Rockman H, Bond RA, Lefkowitz RJ. Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J Thorac Cardiovasc Surg. 1995 Feb; 109(2):236-41. PMID: 7853876.
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    178. Milano CA, Dolber PC, Rockman H, Bond RA, Venable ME, Allen LF, Lefkowitz RJ. Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):10109-13. PMID: 7937846; PMCID: PMC44967.
    179. Rockman H, Wachhorst SP, Mao L, Ross J. ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. Am J Physiol. 1994 Jun; 266(6 Pt 2):H2468-75. PMID: 8024008.
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    180. Milano CA, Allen LF, Rockman H, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science. 1994 Apr 22; 264(5158):582-6. PMID: 8160017.
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    181. Rockman H, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, Ross J, Chien KR. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2694-8. PMID: 8146176; PMCID: PMC43436.
    182. Omens JH, Rockman H, Covell JW. Passive ventricular mechanics in tight-skin mice. Am J Physiol. 1994 Mar; 266(3 Pt 2):H1169-76. PMID: 8160820.
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    183. Ono S, Bhargava V, Ono S, Mao L, Hagan G, Rockman H, Ross J. In vivo assessment of left ventricular remodelling after myocardial infarction by digital video contrast angiography in the rat. Cardiovasc Res. 1994 Mar; 28(3):349-57. PMID: 8174155.
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    184. Oh BH, Ono S, Rockman H, Ross J. Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion. Circulation. 1993 Feb; 87(2):598-607. PMID: 8425304.
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    185. Kambayashi M, Miura T, Oh BH, Murata K, Rockman H, Parra G, Ross J. Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs. Circulation. 1992 Dec; 86(6):1935-44. PMID: 1451265.
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    186. Oh BH, Volpini M, Kambayashi M, Murata K, Rockman H, Kassab GS, Ross J. Myocardial function and transmural blood flow during coronary venous retroperfusion in pigs. Circulation. 1992 Oct; 86(4):1265-79. PMID: 1394933.
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    187. Lee KJ, Ross RS, Rockman H, Harris AN, O'Brien TX, van Bilsen M, Shubeita HE, Kandolf R, Brem G, Price J. Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. J Biol Chem. 1992 Aug 05; 267(22):15875-85. PMID: 1379240.
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    188. Kambayashi M, Miura T, Oh BH, Rockman H, Murata K, Ross J. Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs. Circulation. 1992 Aug; 86(2):572-80. PMID: 1353420.
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