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    Hanne Hoffmann

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0674
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      The Role of the Homeoprotein Vax1 in Fertility and Circadian Rhythm
      NIH K99HD084759Apr 1, 2016 - Mar 31, 2018
      Role: Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hoffmann H, Gong P, Tamrazian A, Mellon PL. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2017 Sep 07. PMID: 28890143.
        View in: PubMed
      2. Hoffmann H, Mellon PL. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst). 2016; 2. PMID: 28164172.
        View in: PubMed
      3. Hoffmann H, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23; 36(12):3506-18. PMID: 27013679; PMCID: PMC4804008.
      4. Xie H, Hoffmann H, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun; 29(6):842-55. PMID: 25915183; PMCID: PMC4447639.
      5. Hoffmann H, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon PL. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct; 155(10):4043-53. PMID: 25060364; PMCID: PMC4164932.
      6. Moreno E, Moreno-Delgado D, Navarro G, Hoffmann H, Fuentes S, Rosell-Vilar S, Gasperini P, Rodríguez-Ruiz M, Medrano M, Mallol J, Cortés A, Casadó V, Lluís C, Ferré S, Ortiz J, Canela E, McCormick PJ. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: s1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 2014 Mar 05; 34(10):3545-58. PMID: 24599455; PMCID: PMC3942573.
      7. Witham EA, Meadows JD, Hoffmann H, Shojaei S, Coss D, Kauffman AS, Mellon PL. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug; 27(8):1283-94. PMID: 23770611; PMCID: PMC3725344.
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