Grant Campbell

Title(s)Project Scientist, Pediatrics
SchoolVc-health Sciences-schools
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    Collapse Biography 
    Collapse Education and Training
    University of Edinburgh, Edinburgh, United KingdomBSc (Hons)06/2000Biological Sciences (Honours in Virology)
    University of Aix-Marseille, Marseille, FrancePhD11/2004Molecular Microbiology and Biotechnology
    University of California San Diego, La Jolla, CAPostdoctoral Scholar11/2009Molecular microbiology

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting HIV Myeloid Reservoirs in the CNS by IAP and TREM1 Inhibition
    NIH R01MH128021Jul 1, 2021 - Apr 30, 2026
    Role: Principal Investigator
    Utilizing autophagy to control HIV and tuberculosis
    CHRP ID12-SD-255Mar 1, 2013 - Feb 28, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells. Theranostics. 2021; 11(18):9009-9021. Campbell GR, Zhuang J, Zhang G, Landa I, Kubiatowicz LJ, Dehaini D, Fang RH, Zhang L, Spector SA. PMID: 34522224; PMCID: PMC8419049.
      View in: PubMed   Mentions:    Fields:    
    2. Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure. Cells. 2021 07 16; 10(7). Campbell GR, Spector SA. PMID: 34359967; PMCID: PMC8307643.
      View in: PubMed   Mentions:    Fields:    
    3. SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway. iScience. 2021 Apr 23; 24(4):102295. Campbell GR, To RK, Hanna J, Spector SA. PMID: 33718825; PMCID: PMC7939994.
      View in: PubMed   Mentions: 7  
    4. CD4+ T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy. mBio. 2020 09 15; 11(5). Zhang G, Campbell GR, Zhang Q, Maule E, Hanna J, Gao W, Zhang L, Spector SA. PMID: 32934078; PMCID: PMC7492730.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages. Cell Death Dis. 2020 07 27; 11(7):590. Campbell GR, To RK, Zhang G, Spector SA. PMID: 32719312; PMCID: PMC7385130.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. mBio. 2019 11 12; 10(6). Campbell GR, To RK, Spector SA. PMID: 31719184; PMCID: PMC6851287.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    7. Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides. Cell Death Dis. 2019 05 29; 10(6):419. Zhang G, Luk BT, Wei X, Campbell GR, Fang RH, Zhang L, Spector SA. PMID: 31142734; PMCID: PMC6541658.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    8. DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection. Autophagy. 2019 04; 15(4):744-746. Campbell GR, Spector SA. PMID: 30653393; PMCID: PMC6526817.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells. Cell Host Microbe. 2018 11 14; 24(5):689-702.e7. Campbell GR, Bruckman RS, Chu YL, Trout RN, Spector SA. PMID: 30344003; PMCID: PMC6250054.
      View in: PubMed   Mentions: 25  Translation:HumansCells
    10. Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication. J Biol Chem. 2018 04 20; 293(16):5808-5820. Campbell GR, Bruckman RS, Herns SD, Joshi S, Durden DL, Spector SA. PMID: 29475942; PMCID: PMC5912471.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    11. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, et al. PMID: 26799652; PMCID: PMC4835977.
      View in: PubMed   Mentions: 2143     Fields:    Translation:HumansAnimals
    12. Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration. PLoS Pathog. 2015 Jun; 11(6):e1005018. Campbell GR, Rawat P, Bruckman RS, Spector SA. PMID: 26115100; PMCID: PMC4482621.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    13. Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1. J Biol Chem. 2015 Feb 20; 290(8):5028-5040. Campbell GR, Bruckman RS, Chu YL, Spector SA. PMID: 25540204; PMCID: PMC4335239.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCellsCTClinical Trials
    14. Autophagy, Infection, and the Immune Response. Modulating Autophagy to Cure Human Immunodeficiency Virus type‐1. 2014; 127-142. Spector SA, Campbell GR. . View Publication.
    15. Inhibition of human immunodeficiency virus type-1 through autophagy. Curr Opin Microbiol. 2013 Jun; 16(3):349-54. Campbell GR, Spector SA. PMID: 23747172; PMCID: PMC3742638.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    16. Vitamin D attenuates nucleoside reverse transcriptase inhibitor induced human skeletal muscle mitochondria DNA depletion. AIDS. 2013 Jun 01; 27(9):1397-401. Campbell GR, Pallack ZT, Spector SA. PMID: 23435299; PMCID: PMC3762245.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013 Feb 14; 494(7436):201-6. Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B. PMID: 23364696; PMCID: PMC3788641.
      View in: PubMed   Mentions: 308     Fields:    Translation:HumansAnimalsCells
    18. Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1. PLoS Pathog. 2012; 8(11):e1003017. Campbell GR, Spector SA. PMID: 23166493; PMCID: PMC3499571.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCellsCTClinical Trials
    19. Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1. Autophagy. 2012 Oct; 8(10):1523-5. Campbell GR, Spector SA. PMID: 22892387; PMCID: PMC3679232.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    20. Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy. PLoS Pathog. 2012; 8(5):e1002689. Campbell GR, Spector SA. PMID: 22589721; PMCID: PMC3349755.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    21. Antiretroviral therapy does not block the secretion of the human immunodeficiency virus tat protein. Infect Disord Drug Targets. 2012 Feb; 12(1):81-6. Mediouni S, Darque A, Baillat G, Ravaux I, Dhiver C, Tissot-Dupont H, Mokhtari M, Moreau H, Tamalet C, Brunet C, Paul P, Dignat-George F, Stein A, Brouqui P, Spector SA, Campbell GR, Loret EP. PMID: 22280310.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    22. Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection. J Biol Chem. 2011 May 27; 286(21):18890-902. Campbell GR, Spector SA. PMID: 21454634; PMCID: PMC3099705.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    23. Differential induction of rat neuronal excitotoxic cell death by human immunodeficiency virus type 1 clade B and C tat proteins. AIDS Res Hum Retroviruses. 2011 Jun; 27(6):647-54. Campbell GR, Watkins JD, Loret EP, Spector SA. PMID: 20977378; PMCID: PMC3101084.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins. J Biol Chem. 2010 Jun 11; 285(24):18319-25. Wong JK, Campbell GR, Spector SA. PMID: 20378550; PMCID: PMC2881757.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. HIV-1 clade B Tat, but not clade C Tat, increases X4 HIV-1 entry into resting but not activated CD4+ T cells. J Biol Chem. 2010 Jan 15; 285(3):1681-91. Campbell GR, Loret EP, Spector SA. PMID: 19917610; PMCID: PMC2804326.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? Retrovirology. 2009 May 25; 6:50. Campbell GR, Loret EP. PMID: 19467159; PMCID: PMC2693501.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    27. Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant. Retrovirology. 2008 Sep 22; 5:83. Watkins JD, Campbell GR, Halimi H, Loret EP. PMID: 18808674; PMCID: PMC2557015.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    28. CCL2 increases X4-tropic HIV-1 entry into resting CD4+ T cells. J Biol Chem. 2008 Nov 07; 283(45):30745-53. Campbell GR, Spector SA. PMID: 18784079; PMCID: PMC2576528.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    29. Tat-specific binding IgG and disease progression in HIV type 1-infected Ugandans. AIDS Res Hum Retroviruses. 2008 Apr; 24(4):587-94. Senkaali D, Kebba A, Shafer LA, Campbell GR, Loret EP, Van Der Paal L, Grosskurth H, Yirrell D, Kaleebu P. PMID: 18366309.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. Tat mutations in an African cohort that do not prevent transactivation but change its immunogenic properties. Vaccine. 2007 Dec 05; 25(50):8441-7. Campbell GR, Senkaali D, Watkins J, Esquieu D, Opi S, Yirrell DL, Kaleebu P, Loret EP. PMID: 17997200.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Human immunodeficiency virus type 1 subtype C Tat fails to induce intracellular calcium flux and induces reduced tumor necrosis factor production from monocytes. J Virol. 2007 Jun; 81(11):5919-28. Campbell GR, Watkins JD, Singh KK, Loret EP, Spector SA. PMID: 17376903; PMCID: PMC1900281.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    32. Reservoir cells no longer detectable after a heterologous SHIV challenge with the synthetic HIV-1 Tat Oyi vaccine. Retrovirology. 2006 Jan 27; 3:8. Watkins JD, Lancelot S, Campbell GR, Esquieu D, de Mareuil J, Opi S, Annappa S, Salles JP, Loret EP. PMID: 16441880; PMCID: PMC1434768.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    33. The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells. J Biol Chem. 2005 Nov 18; 280(46):38376-82. Campbell GR, Watkins JD, Esquieu D, Pasquier E, Loret EP, Spector SA. PMID: 16155003.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    34. HIV-1 Tat protein enhances microtubule polymerization. Retrovirology. 2005 Feb 03; 2:5. de Mareuil J, Carre M, Barbier P, Campbell GR, Lancelot S, Opi S, Esquieu D, Watkins JD, Prevot C, Braguer D, Peyrot V, Loret EP. PMID: 15691386; PMCID: PMC549075.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    35. The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. J Biol Chem. 2004 Nov 12; 279(46):48197-204. Campbell GR, Pasquier E, Watkins J, Bourgarel-Rey V, Peyrot V, Esquieu D, Barbier P, de Mareuil J, Braguer D, Kaleebu P, Yirrell DL, Loret EP. PMID: 15331610.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    36. Full-length HIV-1 Tat protein necessary for a vaccine. Vaccine. 2004 Aug 13; 22(23-24):3105-11. Opi S, Péloponèse JM, Esquieu D, Watkins J, Campbell G, De Mareuil J, Jeang KT, Yirrell DL, Kaleebu P, Loret EP. PMID: 15297062.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor. Bioorg Med Chem Lett. 2004 Mar 22; 14(6):1543-6. Montembault M, Vo-Thanh G, Deyine A, Fargeas V, Villiéras M, Adjou A, Dubreuil D, Esquieu D, Grégoire C, Opi S, Péloponèse JM, Campbell G, Watkins J, de Mareuil J, Aubertin AM, Bailly C, Loret E, Lebreton J. PMID: 15006399.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    38. Discovery of a Tat HIV-1 inhibitor through computer-aided drug design. Spectroscopy. 2003; 17:639-645. Esquieu D, Péloponèse JM, Opi S, Gregoire C, de Mareuil J, Watkins J, Campbell G, Dunot J, Sturgis J, Witvrouw M, Pannecouque C, de Clercq E, Montembault M, Giang V, Villiéras M, Fargeas V, Lebreton J, Loret EP. View Publication.
    39. Tat HIV-1 primary and tertiary structures critical to immune response against non-homologous variants. J Biol Chem. 2002 Sep 27; 277(39):35915-9. Opi S, Péloponèse JM, Esquieu D, Campbell G, de Mareuil J, Walburger A, Solomiac M, Grégoire C, Bouveret E, Yirrell DL, Loret EP. PMID: 12080071.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. Homonuclear (1)H-NMR assignment and structural characterization of human immunodeficiency virus type 1 Tat Mal protein. Biopolymers. 2001; 62(6):324-35. Grégoire C, Péloponèse JM, Esquieu D, Opi S, Campbell G, Solomiac M, Lebrun E, Lebreton J, Loret EP. PMID: 11857271.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
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