Gernot Walter

Title(s)Emeritus Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of PP2A in Lung Cancer
    NIH R01CA118015Jan 1, 2008 - Dec 31, 2011
    Role: Principal Investigator
    Molecular Pathology of Cancer Training Grant
    NIH T32CA077109Jul 1, 1998 - Jul 31, 2010
    Role: Co-Principal Investigator
    PROTEIN PHOSPHATASE 2A AND TUMOR ANTIGENS IN CELL GROWTH
    NIH R01CA036111Dec 1, 1983 - Nov 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways. Cell Cycle. 2012 Feb 01; 11(3):451-9. Walter G, Ruediger R. PMID: 22262169; PMCID: PMC3315090.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    2. Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice. Mol Cell Biol. 2011 Sep; 31(18):3832-44. Ruediger R, Ruiz J, Walter G. PMID: 21791616; PMCID: PMC3165721.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    3. Mutagenesis and expression of the scaffolding Aalpha and Abeta subunits of PP2A: assays for measuring defects in binding of cancer-related Aalpha and Abeta mutants to the regulatory B and catalytic C subunits. Methods Mol Biol. 2007; 365:85-99. Ruediger R, Zhou J, Walter G. PMID: 17200556.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Purification of PP2A holoenzymes by sequential immunoprecipitation with anti-peptide antibodies. Methods Mol Biol. 2007; 365:113-26. Walter G, Zhou J, Ruediger R. PMID: 17200558.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol. 2006 Mar; 26(5):1997-2011. Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G. PMID: 16479016; PMCID: PMC1430240.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    6. The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit. J Biol Chem. 2003 Mar 07; 278(10):8617-22. Zhou J, Pham HT, Walter G. PMID: 12506124.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    7. Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. J Biol Chem. 2002 Jun 07; 277(23):20750-5. Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT. PMID: 11929880.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    8. Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene. 2001 Apr 05; 20(15):1892-9. Ruediger R, Pham HT, Walter G. PMID: 11313937.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    9. Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene. Oncogene. 2001 Jan 04; 20(1):10-5. Ruediger R, Pham HT, Walter G. PMID: 11244497.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    10. Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1307-18. Brewis N, Ohst K, Fields K, Rapacciuolo A, Chou D, Bloor C, Dillmann W, Rockman H, Walter G. PMID: 10993798.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    11. Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. J Virol. 1999 Jan; 73(1):839-42. Ruediger R, Fields K, Walter G. PMID: 9847399; PMCID: PMC103900.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    12. Protein phosphatase 2A is required for the initiation of chromosomal DNA replication. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14693-8. Lin XH, Walter J, Scheidtmann K, Ohst K, Newport J, Walter G. PMID: 9843951; PMCID: PMC24511.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    13. Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds. Biochem Pharmacol. 1998 Apr 01; 55(7):1105-11. Leoni LM, Shih HC, Deng L, Tuey C, Walter G, Carson DA, Cottam HB. PMID: 9605434.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. Virology. 1997 Nov 24; 238(2):432-43. Ruediger R, Brewis N, Ohst K, Walter G. PMID: 9400615.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. Quantitation of luciferase reporter mRNA by in vitro translation of total cellular RNA is faster and more sensitive than northern blotting and primer extension. Anal Biochem. 1997 Nov 15; 253(2):267-9. Ruediger R, Walter G. PMID: 9367515.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Crystallization of the A alpha subunit of protein phosphatase 2A. Protein Sci. 1996 Jun; 5(6):1198-200. Skidmore MO, Sawaya MR, Parkin S, Rupp B, Hope H, Everse SJ, Walter G. PMID: 8762154; PMCID: PMC2143440.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J Virol. 1994 Jan; 68(1):123-9. Ruediger R, Hentz M, Fait J, Mumby M, Walter G. PMID: 8254721; PMCID: PMC236271.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    18. Protein serine/threonine phosphatases and cell transformation. Biochim Biophys Acta. 1993 Aug 23; 1155(2):207-26. Walter G, Mumby M. PMID: 8395218.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus. Mol Cell Biol. 1992 Nov; 12(11):4872-82. Ruediger R, Roeckel D, Fait J, Bergqvist A, Magnusson G, Walter G. PMID: 1328865; PMCID: PMC360420.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    20. Constant expression and activity of protein phosphatase 2A in synchronized cells. Mol Cell Biol. 1991 Aug; 11(8):4282-5. Ruediger R, Van Wart Hood JE, Mumby M, Walter G. PMID: 1649390; PMCID: PMC361261.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    21. Increased expression of pp60c-src protein-tyrosine kinase during peripheral nerve regeneration. J Neurosci Res. 1991 Feb; 28(2):299-309. Le Beau JM, Tedeschi B, Walter G. PMID: 1709691.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Association of protein phosphatase 2A with polyoma virus medium tumor antigen. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2521-5. Walter G, Ruediger R, Slaughter C, Mumby M. PMID: 2157202; PMCID: PMC53721.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    23. Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8669-72. Walter G, Ferre F, Espiritu O, Carbone-Wiley A. PMID: 2554323; PMCID: PMC298349.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    24. Homologous cellular proteins associated with simian virus 40 small T antigen and polyomavirus medium T antigen. J Virol. 1988 Dec; 62(12):4760-2. Walter G, Carbone-Wiley A, Joshi B, Rundell K. PMID: 3184277; PMCID: PMC253593.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    25. Specific kinase activity and phosphorylation state of pp60c-src from neuroblastomas and fibroblasts. Oncogene. 1988 Sep; 3(3):237-44. Yang XM, Walter G. PMID: 2462704.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. In vitro phosphorylation of SV40 large T antigen. Virology. 1988 Jul; 165(1):13-22. Grässer FA, Scheidtmann KH, Tuazon PT, Traugh JA, Walter G. PMID: 2838952.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    27. Sensitive two-site sandwich enzyme immunoassay with antipeptide antibodies for detection of viral antigens. J Immunol Methods. 1988 Jun 13; 110(2):153-9. Wiestler OD, Walter G. PMID: 2837513.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. Developmental expression of two forms of pp60c-src in mouse brain. Mol Cell Biol. 1988 Jan; 8(1):502-4. Wiestler OD, Walter G. PMID: 2447488; PMCID: PMC363161.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    29. An altered form of pp60c-src is expressed primarily in the central nervous system. Mol Cell Biol. 1987 Nov; 7(11):4115-7. Le Beau JM, Wiestler OD, Walter G. PMID: 2448603; PMCID: PMC368082.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    30. Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding. J Virol. 1987 Nov; 61(11):3373-80. Grässer FA, Mann K, Walter G. PMID: 2822947; PMCID: PMC255931.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
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