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Gernot Walter

Title(s)Emeritus Professor, Pathology
SchoolHealth Sciences
Phone858-534-1894
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of PP2A in Lung Cancer
    NIH/NCI R01CA118015Jan 1, 2008 - Dec 31, 2011
    Role: Principal Investigator
    Molecular Pathology of Cancer Training Grant
    NIH/NCI T32CA077109Jul 1, 1998 - Jul 31, 2010
    Role: Co-Principal Investigator
    PROTEIN PHOSPHATASE 2A AND TUMOR ANTIGENS IN CELL GROWTH
    NIH/NCI R01CA036111Dec 1, 1983 - Nov 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Walter G, Ruediger R. Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways. Cell Cycle. 2012 Feb 01; 11(3):451-9. PMID: 22262169; PMCID: PMC3315090.
    2. Ruediger R, Ruiz J, Walter G. Human cancer-associated mutations in the Aa subunit of protein phosphatase 2A increase lung cancer incidence in Aa knock-in and knockout mice. Mol Cell Biol. 2011 Sep; 31(18):3832-44. PMID: 21791616; PMCID: PMC3165721.
    3. Walter G, Zhou J, Ruediger R. Purification of PP2A holoenzymes by sequential immunoprecipitation with anti-peptide antibodies. Methods Mol Biol. 2007; 365:113-26. PMID: 17200558.
      View in: PubMed
    4. Ruediger R, Zhou J, Walter G. Mutagenesis and expression of the scaffolding Aalpha and Abeta subunits of PP2A: assays for measuring defects in binding of cancer-related Aalpha and Abeta mutants to the regulatory B and catalytic C subunits. Methods Mol Biol. 2007; 365:85-99. PMID: 17200556.
      View in: PubMed
    5. Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol. 2006 Mar; 26(5):1997-2011. PMID: 16479016; PMCID: PMC1430240.
    6. Zhou J, Pham HT, Ruediger R, Walter G. Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution. Biochem J. 2003 Jan 15; 369(Pt 2):387-98. PMID: 12370081; PMCID: PMC1223084.
    7. Zhou J, Pham HT, Walter G. The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit. J Biol Chem. 2003 Mar 07; 278(10):8617-22. PMID: 12506124.
      View in: PubMed
    8. Chou DM, Petersen P, Walter JC, Walter G. Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex. J Biol Chem. 2002 Oct 25; 277(43):40520-7. PMID: 12185086.
      View in: PubMed
    9. Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT. Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. J Biol Chem. 2002 Jun 07; 277(23):20750-5. PMID: 11929880.
      View in: PubMed
    10. Ruediger R, Pham HT, Walter G. Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene. 2001 Apr 05; 20(15):1892-9. PMID: 11313937.
      View in: PubMed
    11. Ruediger R, Pham HT, Walter G. Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene. Oncogene. 2001 Jan 04; 20(1):10-5. PMID: 11244497.
      View in: PubMed
    12. Brewis N, Ohst K, Fields K, Rapacciuolo A, Chou D, Bloor C, Dillmann W, Rockman H, Walter G. Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1307-18. PMID: 10993798.
      View in: PubMed
    13. Ruediger R, Fields K, Walter G. Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. J Virol. 1999 Jan; 73(1):839-42. PMID: 9847399; PMCID: PMC103900.
    14. Lin XH, Walter J, Scheidtmann K, Ohst K, Newport J, Walter G. Protein phosphatase 2A is required for the initiation of chromosomal DNA replication. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14693-8. PMID: 9843951; PMCID: PMC24511.
    15. Leoni LM, Shih HC, Deng L, Tuey C, Walter G, Carson DA, Cottam HB. Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds. Biochem Pharmacol. 1998 Apr 01; 55(7):1105-11. PMID: 9605434.
      View in: PubMed
    16. Ruediger R, Brewis N, Ohst K, Walter G. Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. Virology. 1997 Nov 24; 238(2):432-43. PMID: 9400615.
      View in: PubMed
    17. Ruediger R, Walter G. Quantitation of luciferase reporter mRNA by in vitro translation of total cellular RNA is faster and more sensitive than northern blotting and primer extension. Anal Biochem. 1997 Nov 15; 253(2):267-9. PMID: 9367515.
      View in: PubMed
    18. Skidmore MO, Sawaya MR, Parkin S, Rupp B, Hope H, Everse SJ, Walter G. Crystallization of the A alpha subunit of protein phosphatase 2A. Protein Sci. 1996 Jun; 5(6):1198-200. PMID: 8762154; PMCID: PMC2143440.
    19. Ruediger R, Hentz M, Fait J, Mumby M, Walter G. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J Virol. 1994 Jan; 68(1):123-9. PMID: 8254721; PMCID: PMC236271.
    20. Walter G, Mumby M. Protein serine/threonine phosphatases and cell transformation. Biochim Biophys Acta. 1993 Aug 23; 1155(2):207-26. PMID: 8395218.
      View in: PubMed
    21. Ruediger R, Roeckel D, Fait J, Bergqvist A, Magnusson G, Walter G. Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus. Mol Cell Biol. 1992 Nov; 12(11):4872-82. PMID: 1328865; PMCID: PMC360420.
    22. Ruediger R, Van Wart Hood JE, Mumby M, Walter G. Constant expression and activity of protein phosphatase 2A in synchronized cells. Mol Cell Biol. 1991 Aug; 11(8):4282-5. PMID: 1649390; PMCID: PMC361261.
    23. Le Beau JM, Tedeschi B, Walter G. Increased expression of pp60c-src protein-tyrosine kinase during peripheral nerve regeneration. J Neurosci Res. 1991 Feb; 28(2):299-309. PMID: 1709691.
      View in: PubMed
    24. Walter G, Ruediger R, Slaughter C, Mumby M. Association of protein phosphatase 2A with polyoma virus medium tumor antigen. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2521-5. PMID: 2157202; PMCID: PMC53721.
    25. Walter G, Ferre F, Espiritu O, Carbone-Wiley A. Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8669-72. PMID: 2554323; PMCID: PMC298349.
    26. Walter G, Carbone-Wiley A, Joshi B, Rundell K. Homologous cellular proteins associated with simian virus 40 small T antigen and polyomavirus medium T antigen. J Virol. 1988 Dec; 62(12):4760-2. PMID: 3184277; PMCID: PMC253593.
    27. Yang XM, Walter G. Specific kinase activity and phosphorylation state of pp60c-src from neuroblastomas and fibroblasts. Oncogene. 1988 Sep; 3(3):237-44. PMID: 2462704.
      View in: PubMed
    28. Grässer FA, Scheidtmann KH, Tuazon PT, Traugh JA, Walter G. In vitro phosphorylation of SV40 large T antigen. Virology. 1988 Jul; 165(1):13-22. PMID: 2838952.
      View in: PubMed
    29. Wiestler OD, Walter G. Sensitive two-site sandwich enzyme immunoassay with antipeptide antibodies for detection of viral antigens. J Immunol Methods. 1988 Jun 13; 110(2):153-9. PMID: 2837513.
      View in: PubMed
    30. Wiestler OD, Walter G. Developmental expression of two forms of pp60c-src in mouse brain. Mol Cell Biol. 1988 Jan; 8(1):502-4. PMID: 2447488.
      View in: PubMed
    31. Grässer FA, Mann K, Walter G. Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding. J Virol. 1987 Nov; 61(11):3373-80. PMID: 2822947; PMCID: PMC255931.
    32. Le Beau JM, Wiestler OD, Walter G. An altered form of pp60c-src is expressed primarily in the central nervous system. Mol Cell Biol. 1987 Nov; 7(11):4115-7. PMID: 2448603.
      View in: PubMed