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Geoffrey Chang

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0754
La Jolla CA 92093
Phone858-822-5490
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of Pennsylvania

    Collapse Research 
    Collapse Research Activities and Funding
    Identity, mechanisms and early life impacts of transporter interfering compounds
    NIH/NIEHS R01ES027921Jun 1, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Structure-based optimization of a novel pharmacological chaperone therapy for MPSIIIC
    NIH/NICHD R41HD092110Sep 15, 2017 - Aug 31, 2018
    Role: Co-Principal Investigator
    A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)
    NIH/NEI R21EY028399Sep 1, 2017 - Aug 31, 2019
    Role: Co-Principal Investigator
    Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease
    NIH/NINDS R01NS087611May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Structure and function of ABC transporters to understand persistence of global ma
    NIH/NIEHS R01ES021985Sep 24, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Molecular Organization of the Organic Cation-Proton Exchanger, MATE1
    NIH/NIDDK R01DK080801Sep 30, 2010 - Jul 31, 2015
    Role: Principal Investigator
    TransportPDB: Center for the X-ray Structure Determination of Human Transporters
    NIH/NIGMS U54GM094610Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Structural biology and high resolution studies of P-glycoprotein
    NIH/NIGMS R01GM094367Sep 20, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Affinity maturation via in vitro evolution at the lab bench-top
    NIH/NIGMS R01GM094955Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Inhibition of Malaria Chloroquine Resistance Transporters
    NIH/NIAID R56AI090832Jun 21, 2010 - May 31, 2012
    Role: Principal Investigator
    Crystallography of MATE Transporters
    NIH/NIGMS R01GM070480Feb 1, 2005 - Jan 31, 2011
    Role: Principal Investigator
    JCIMPT-Complexes
    NIH/NIGMS P50GM073197Sep 24, 2004 - Jul 31, 2014
    Role: Co-Investigator
    X-ray Structures of Small MDR Efflux Pumps
    NIH/NIGMS R01GM067644Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator
    Crystallography of Multi-Drug Resistant MFS Transporters
    NIH/NIGMS R21GM065798Sep 24, 2001 - Aug 31, 2003
    Role: Principal Investigator
    Structural Biology and Inhibition of MDR ABC Transporters
    NIH/NIGMS R01GM061905Sep 1, 2000 - Jun 30, 2011
    Role: Principal Investigator
    Molecular Organization of Renal and Hepatic Organic Cation Transporters
    NIH/NIDDK R01DK058251Aug 15, 2000 - Jul 31, 2017
    Role: Principal Investigator
    HIGH RESOLUTION STRUCTURE OF THE POTASSIUM ION CHANNEL
    NIH/NIGMS F32GM018486Jan 7, 1997
    Role: Principal Investigator
    BioCARS: A Synchroton Structural Biology Resource
    NIH P41RR007707Sep 15, 1992 - Jul 31, 2013
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pieper U, Schlessinger A, Kloppmann E, Chang G, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. Coordinating the impact of structural genomics on the human a-helical transmembrane proteome. Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. PMID: 23381628; PMCID: PMC3645303.
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