Geoffrey Chang

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of Pennsylvania

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Development of low-cost, field-ready nanobodies against snake venom
    NIH R41GM146314Sep 15, 2021 - Sep 14, 2022
    Role: Co-Principal Investigator
    TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
    NIH R01NS121604Apr 1, 2021 - Mar 31, 2026
    Role: Co-Principal Investigator
    Nanobody inhibitors of proton-sensing G protein-coupled receptors
    NIH R03TR003639Apr 1, 2021 - Mar 31, 2022
    Role: Principal Investigator
    Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers
    NIH R21EY031277Sep 30, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Identity, mechanisms and early life impacts of transporter interfering compounds
    NIH R01ES027921Jun 1, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Structure-based optimization of a novel pharmacological chaperone therapy for MPSIIIC
    NIH R41HD092110Sep 15, 2017 - Aug 31, 2020
    Role: Co-Principal Investigator
    A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)
    NIH R21EY028399Sep 1, 2017 - Aug 31, 2020
    Role: Co-Principal Investigator
    Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease
    NIH R01NS087611May 1, 2014 - Apr 30, 2020
    Role: Principal Investigator
    Structure and function of ABC transporters to understand persistence of global ma
    NIH R01ES021985Sep 24, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Molecular Organization of the Organic Cation-Proton Exchanger, MATE1
    NIH R01DK080801Sep 30, 2010 - Jul 31, 2017
    Role: Principal Investigator
    TransportPDB: Center for the X-ray Structure Determination of Human Transporters
    NIH U54GM094610Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Structural biology and high resolution studies of P-glycoprotein
    NIH R01GM094367Sep 20, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Affinity maturation via in vitro evolution at the lab bench-top
    NIH R01GM094955Sep 1, 2010 - Aug 31, 2016
    Role: Principal Investigator
    Inhibition of Malaria Chloroquine Resistance Transporters
    NIH R56AI090832Jun 21, 2010 - May 31, 2012
    Role: Principal Investigator
    Crystallography of MATE Transporters
    NIH R01GM070480Feb 1, 2005 - Jan 31, 2011
    Role: Principal Investigator
    NIH P50GM073197Sep 24, 2004 - Dec 31, 2014
    Role: Co-Investigator
    X-ray Structures of Small MDR Efflux Pumps
    NIH R01GM067644Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator
    Crystallography of Multi-Drug Resistant MFS Transporters
    NIH R21GM065798Sep 24, 2001 - Aug 31, 2003
    Role: Principal Investigator
    Structural Biology and Inhibition of MDR ABC Transporters
    NIH R01GM061905Sep 1, 2000 - Jun 30, 2011
    Role: Principal Investigator
    Molecular Organization of Renal and Hepatic Organic Cation Transporters
    NIH R01DK058251Aug 15, 2000 - Jul 31, 2018
    Role: Principal Investigator
    NIH F32GM018486Jan 7, 1997
    Role: Principal Investigator
    BioCARS: A Synchroton Structural Biology Resource
    NIH P41RR007707Sep 15, 1992 - Jul 31, 2013
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Computational models in the service of X-ray and cryo-electron microscopy structure determination. Proteins. 2021 12; 89(12):1633-1646. Kryshtafovych A, Moult J, Albrecht R, Chang GA, Chao K, Fraser A, Greenfield J, Hartmann MD, Herzberg O, Josts I, Leiman PG, Linden SB, Lupas AN, Nelson DC, Rees SD, Shang X, Sokolova ML, Tidow H, AlphaFold2 team. PMID: 34449113; PMCID: PMC8616789.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    2. Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. PMID: 23381628; PMCID: PMC3645303.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
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