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Gary Bennett

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #0818
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of chemotherapy-evoked neuropathic pain
    NIH/NINDS R01NS052255May 10, 2006 - Apr 30, 2011
    Role: Principal Investigator
    NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITIS
    NIH/NINDS R01NS036834Jul 3, 1998 - Jun 30, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, Weng HR, Spiegel S, Salvemini D. Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. J Exp Med. 2018 May 07; 215(5):1301-1313. PMID: 29703731.
      View in: PubMed
    2. Bennett GJ. Does the word "placebo" evoke a placebo response? Pain. 2018 Apr 27. PMID: 29781958.
      View in: PubMed
    3. Ragavendran JV, Laferrière A, Bennett GJ, Ware MA, Gandhi W, Bley K, Schweinhardt P, Coderre TJ. Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study. Pain. 2016 10; 157(10):2366-74. PMID: 27385502.
      View in: PubMed
    4. Tuttle AH, Tohyama S, Ramsay T, Kimmelman J, Schweinhardt P, Bennett GJ, Mogil JS. Increasing placebo responses over time in U.S. clinical trials of neuropathic pain. Pain. 2015 Dec; 156(12):2616-26. PMID: 26307858.
      View in: PubMed
    5. Bennett GJ, Doyle T, Salvemini D. Mitotoxicity in distal symmetrical sensory peripheral neuropathies. Nat Rev Neurol. 2014 Jun; 10(6):326-36. PMID: 24840972; PMCID: PMC4870000.
    6. Ware MA, Bennett GJ. Case report: Long-standing complex regional pain syndrome relieved by a cephalosporin antibiotic. Pain. 2014 Jul; 155(7):1412-5. PMID: 24667741.
      View in: PubMed
    7. Watson CP, Mackinnon SE, Dostrovsky JO, Bennett GJ, Farran RP, Carlson T. Nerve resection, crush and re-location relieve complex regional pain syndrome type II: a case report. Pain. 2014 Jun; 155(6):1168-73. PMID: 24502845.
      View in: PubMed
    8. Drummond ES, Dawson LF, Finch PM, Bennett GJ, Drummond PD. Increased expression of cutaneous a1-adrenoceptors after chronic constriction injury in rats. J Pain. 2014 Feb; 15(2):188-96. PMID: 24212069.
      View in: PubMed
    9. Janes K, Doyle T, Bryant L, Esposito E, Cuzzocrea S, Ryerse J, Bennett GJ, Salvemini D. Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase. Pain. 2013 Nov; 154(11):2432-40. PMID: 23891899; PMCID: PMC4870004.
    10. Ragavendran JV, Laferrière A, Xiao WH, Bennett GJ, Padi SS, Zhang J, Coderre TJ. Topical combinations aimed at treating microvascular dysfunction reduce allodynia in rat models of CRPS-I and neuropathic pain. J Pain. 2013 Jan; 14(1):66-78. PMID: 23273834; PMCID: PMC4467968.
    11. Bennett GJ. What is spontaneous pain and who has it? J Pain. 2012 Oct; 13(10):921-9. PMID: 22824584.
      View in: PubMed
    12. Oaklander AL, Wilson PR, Moskovitz PA, Manning DC, Lubenow T, Levine JD, Harden RN, Galer BS, Cooper MS, Bruehl S, Broatch J, Berde C, Bennett GJ. Response to "A new definition of neuropathic pain". Pain. 2012 Apr; 153(4):934-5; author reply 935-6. PMID: 22342073.
      View in: PubMed
    13. Xiao WH, Bennett GJ. Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin. Pain. 2012 Mar; 153(3):704-9. PMID: 22244441; PMCID: PMC3288606.
    14. Farmer MA, Taylor AM, Bailey AL, Tuttle AH, MacIntyre LC, Milagrosa ZE, Crissman HP, Bennett GJ, Ribeiro-da-Silva A, Binik YM, Mogil JS. Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia. Sci Transl Med. 2011 Sep 21; 3(101):101ra91. PMID: 21937756; PMCID: PMC3243907.
    15. Zheng H, Xiao WH, Bennett GJ. Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy. Exp Neurol. 2011 Dec; 232(2):154-61. PMID: 21907196; PMCID: PMC3202047.
    16. Almarestani L, Fitzcharles MA, Bennett GJ, Ribeiro-da-Silva A. Imaging studies in Freund's complete adjuvant model of regional polyarthritis, a model suitable for the study of pain mechanisms, in the rat. Arthritis Rheum. 2011 Jun; 63(6):1573-81. PMID: 21337537.
      View in: PubMed
    17. Burlina AP, Sims KB, Politei JM, Bennett GJ, Baron R, Sommer C, Møller AT, Hilz MJ. Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel. BMC Neurol. 2011 May 27; 11:61. PMID: 21619592; PMCID: PMC3126707.
    18. Bennett GJ, Liu GK, Xiao WH, Jin HW, Siau C. Terminal arbor degeneration--a novel lesion produced by the antineoplastic agent paclitaxel. Eur J Neurosci. 2011 May; 33(9):1667-76. PMID: 21395870; PMCID: PMC3086946.
    19. Ware MA, Wang T, Shapiro S, Robinson A, Ducruet T, Huynh T, Gamsa A, Bennett GJ, Collet JP. Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ. 2010 Oct 05; 182(14):E694-701. PMID: 20805210; PMCID: PMC2950205.
    20. Coderre TJ, Bennett GJ. A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology. Pain Med. 2010 Aug; 11(8):1224-38. PMID: 20704671; PMCID: PMC4467969.
    21. Mogil JS, Graham AC, Ritchie J, Hughes SF, Austin JS, Schorscher-Petcu A, Langford DJ, Bennett GJ. Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice. Mol Pain. 2010 Jun 08; 6:34. PMID: 20529328; PMCID: PMC2893131.
    22. Bennett GJ. Pathophysiology and animal models of cancer-related painful peripheral neuropathy. Oncologist. 2010; 15 Suppl 2:9-12. PMID: 20489191.
      View in: PubMed
    23. Xiao WH, Zheng FY, Bennett GJ, Bordet T, Pruss RM. Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15; 147(1-3):202-9. PMID: 19833436; PMCID: PMC2787910.
    24. Sang CN, Bennett GJ. Novel therapies for the control and prevention of neuropathic pain. Neurotherapeutics. 2009 Oct; 6(4):607-8. PMID: 19789065.
      View in: PubMed
    25. Bennett GJ, Watson CP. Herpes zoster and postherpetic neuralgia: past, present and future. Pain Res Manag. 2009 Jul-Aug; 14(4):275-82. PMID: 19714266; PMCID: PMC2734513.
    26. Dworkin RH, Barbano RL, Tyring SK, Betts RF, McDermott MP, Pennella-Vaughan J, Bennett GJ, Berber E, Gnann JW, Irvine C, Kamp C, Kieburtz K, Max MB, Schmader KE. A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. Pain. 2009 Apr; 142(3):209-17. PMID: 19195785.
      View in: PubMed
    27. Laferrière A, Millecamps M, Xanthos DN, Xiao WH, Siau C, de Mos M, Sachot C, Ragavendran JV, Huygen FJ, Bennett GJ, Coderre TJ. Cutaneous tactile allodynia associated with microvascular dysfunction in muscle. Mol Pain. 2008 Oct 28; 4:49. PMID: 18957097; PMCID: PMC2584041.
    28. Schukken YH, González RN, Tikofsky LL, Schulte HF, Santisteban CG, Welcome FL, Bennett GJ, Zurakowski MJ, Zadoks RN. CNS mastitis: nothing to worry about? Vet Microbiol. 2009 Feb 16; 134(1-2):9-14. PMID: 18842362.
      View in: PubMed
    29. Xiao W, Naso L, Bennett GJ. Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies. Pain Med. 2008 Jul-Aug; 9(5):505-17. PMID: 18777607.
      View in: PubMed
    30. Coderre TJ, Bennett GJ. Objectifying CRPS-I. Pain. 2008 Aug 15; 138(1):3-4. PMID: 18584964; PMCID: PMC4531088.
    31. Xiao WH, Bennett GJ. C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels. Pain. 2008 Jul; 137(1):218-28. PMID: 18395983.
      View in: PubMed
    32. Hayashi R, Xiao W, Kawamoto M, Yuge O, Bennett GJ. Systemic glucocorticoid therapy reduces pain and the number of endoneurial tumor necrosis factor-alpha (TNFalpha)-positive mast cells in rats with a painful peripheral neuropathy. J Pharmacol Sci. 2008 Apr; 106(4):559-65. PMID: 18385539.
      View in: PubMed
    33. Xanthos DN, Bennett GJ, Coderre TJ. Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain. Pain. 2008 Jul 31; 137(3):640-51. PMID: 18079061; PMCID: PMC4494839.
    34. Jin HW, Flatters SJ, Xiao WH, Mulhern HL, Bennett GJ. Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. Exp Neurol. 2008 Mar; 210(1):229-37. PMID: 18078936; PMCID: PMC2323600.
    35. Xiao WH, Bennett GJ. Persistent low-frequency spontaneous discharge in A-fiber and C-fiber primary afferent neurons during an inflammatory pain condition. Anesthesiology. 2007 Nov; 107(5):813-21. PMID: 18073557.
      View in: PubMed
    36. Xiao WH, Bennett GJ. Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine. Pain. 2008 Apr; 135(3):262-70. PMID: 17659836; PMCID: PMC2689385.
    37. Siau C, Xiao W, Bennett GJ. Paclitaxel- and vincristine-evoked painful peripheral neuropathies: loss of epidermal innervation and activation of Langerhans cells. Exp Neurol. 2006 Oct; 201(2):507-14. PMID: 16797537; PMCID: PMC1805691.
    38. Amir R, Argoff CE, Bennett GJ, Cummins TR, Durieux ME, Gerner P, Gold MS, Porreca F, Strichartz GR. The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain. 2006 May; 7(5 Suppl 3):S1-29. PMID: 16632328.
      View in: PubMed
    39. Siau C, Bennett GJ. Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy. Anesth Analg. 2006 May; 102(5):1485-90. PMID: 16632831; PMCID: PMC1805480.
    40. Yen LD, Bennett GJ, Ribeiro-da-Silva A. Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury. J Comp Neurol. 2006 Apr 20; 495(6):679-90. PMID: 16506190.
      View in: PubMed
    41. Argoff CE, Backonja MM, Belgrade MJ, Bennett GJ, Clark MR, Cole BE, Fishbain DA, Irving GA, McCarberg BH, McLean MJ. Consensus guidelines: treatment planning and options. Diabetic peripheral neuropathic pain. Mayo Clin Proc. 2006 Apr; 81(4 Suppl):S12-25. PMID: 16608049.
      View in: PubMed
    42. Flatters SJ, Bennett GJ. Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain. 2006 Jun; 122(3):245-57. PMID: 16530964; PMCID: PMC1805481.
    43. Flatters SJ, Xiao WH, Bennett GJ. Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. Neurosci Lett. 2006 Apr 24; 397(3):219-23. PMID: 16406309; PMCID: PMC1805703.
    44. Cianfrocca M, Flatters SJ, Bennett GJ, McNicol E, Relias V, Carr D, Gillis TA. Peripheral neuropathy in a woman with breast cancer. J Pain. 2006 Jan; 7(1):2-10. PMID: 16414547.
      View in: PubMed
    45. Villemure C, Wassimi S, Bennett GJ, Shir Y, Bushnell MC. Unpleasant odors increase pain processing in a patient with neuropathic pain: psychophysical and fMRI investigation. Pain. 2006 Jan; 120(1-2):213-20. PMID: 16361059.
      View in: PubMed
    46. Davies SL, Siau C, Bennett GJ. Characterization of a model of cutaneous inflammatory pain produced by an ultraviolet irradiation-evoked sterile injury in the rat. J Neurosci Methods. 2005 Oct 30; 148(2):161-6. PMID: 16024087.
      View in: PubMed
    47. Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain. 2004 Nov; 112(1-2):94-105. PMID: 15494189.
      View in: PubMed
    48. Mailis-Gagnon A, Bennett GJ. Abnormal contralateral pain responses from an intradermal injection of phenylephrine in a subset of patients with complex regional pain syndrome (CRPS). Pain. 2004 Oct; 111(3):378-84. PMID: 15363882.
      View in: PubMed
    49. Pérez J, Ware MA, Chevalier S, Gougeon R, Bennett GJ, Shir Y. Dietary fat and protein interact in suppressing neuropathic pain-related disorders following a partial sciatic ligation injury in rats. Pain. 2004 Oct; 111(3):297-305. PMID: 15363873.
      View in: PubMed
    50. Flatters SJ, Bennett GJ. Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain. 2004 May; 109(1-2):150-61. PMID: 15082137.
      View in: PubMed
    51. Lee BN, Dantzer R, Langley KE, Bennett GJ, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Cleeland CS. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation. 2004; 11(5):279-92. PMID: 15316238.
      View in: PubMed
    52. Bennett GJ. Neuropathic pain in the orofacial region: clinical and research challenges. J Orofac Pain. 2004; 18(4):281-6. PMID: 15636009.
      View in: PubMed
    53. Bennett GJ, Harden RN. Questions concerning the incidence and prevalence of complex regional pain syndrome type I (RSD). Pain. 2003 Nov; 106(1-2):209-10; author reply 210-1. PMID: 14581129.
      View in: PubMed
    54. Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, Hewitt DJ, Loeser JD, Max MB, Saltarelli M, Schmader KE, Stein C, Thompson D, Turk DC, Wallace MS, Watkins LR, Weinstein SM. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol. 2003 Nov; 60(11):1524-34. PMID: 14623723.
      View in: PubMed
    55. Bennett GJ. Neuropathic pain: a crisis of definition? Anesth Analg. 2003 Sep; 97(3):619-20. PMID: 12933371.
      View in: PubMed
    56. Bennett GJ, Chung JM, Honore M, Seltzer Z. Models of neuropathic pain in the rat. Curr Protoc Pharmacol. 2003 Jul; Chapter 5:Unit5.32. PMID: 21956807.
      View in: PubMed
    57. Cleeland CS, Bennett GJ, Dantzer R, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Lee BN. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer. 2003 Jun 01; 97(11):2919-25. PMID: 12767108.
      View in: PubMed
    58. Bennett GJ, Chung JM, Honore M, Seltzer Z. Models of neuropathic pain in the rat. Curr Protoc Neurosci. 2003 May; Chapter 9:Unit 9.14. PMID: 18428587.
      View in: PubMed
    59. Mailis A, Bennett GJ. Dissociation between cutaneous and deep sensibility in central post-stroke pain (CPSP). Pain. 2002 Aug; 98(3):331-4. PMID: 12127035.
      View in: PubMed
    60. Wallace MS, Rowbotham M, Bennett GJ, Jensen TS, Pladna R, Quessy S. A multicenter, double-blind, randomized, placebo-controlled crossover evaluation of a short course of 4030W92 in patients with chronic neuropathic pain. J Pain. 2002 Jun; 3(3):227-33. PMID: 14622777.
      View in: PubMed
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