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Gareth Jennings

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0751
La Jolla CA 92093
Phone858-822-5434
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PLoS Pathog. 2018 Sep; 14(9):e1007245. PMID: 30212566.
      View in: PubMed
    2. Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Costi R, Di Santo R. Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. Eur J Med Chem. 2018 Jun 28; 156:53-60. PMID: 30006174.
      View in: PubMed
    3. Jennings GK, Hsu MH, Shock LS, Johnson EF, Hackett JC. Non-covalent interactions dominate dynamic heme distortion in cytochrome P450 4B1. J Biol Chem. 2018 Jun 01. PMID: 29858244.
      View in: PubMed
    4. Zarate-Perez F, Velázquez-Fernández JB, Jennings GK, Shock LS, Lyons CE, Hackett JC. Biophysical characterization of Aptenodytes forsteri cytochrome P450 aromatase. J Inorg Biochem. 2018 Apr 07; 184:79-87. PMID: 29684698.
      View in: PubMed
    5. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. PMID: 29284029.
      View in: PubMed
    6. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 Feb 17; 12(2):422-434. PMID: 27977118.
      View in: PubMed
    7. Jennings GK, Ritchie CM, Shock LS, Lyons CE, Hackett JC. N-Heterocyclic Carbene Capture by Cytochrome P450 3A4. Mol Pharmacol. 2016 07; 90(1):42-51. PMID: 27126611; PMCID: PMC4931868 [Available on 07/01/17].
    8. Di Nardo G, Breitner M, Bandino A, Ghosh D, Jennings GK, Hackett JC, Gilardi G. Evidence for an elevated aspartate pK(a) in the active site of human aromatase. J Biol Chem. 2015 Jan 09; 290(2):1186-96. PMID: 25425647; PMCID: PMC4294484.
    9. Jennings GK, Modi A, Elenewski JE, Ritchie CM, Nguyen T, Ellis KC, Hackett JC. Spin equilibrium and O2-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyad. J Inorg Biochem. 2014 Jul; 136:81-91. PMID: 24793591; PMCID: PMC4085784.