Francesca Soncin

Title(s)Assistant Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-7423-9167 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Turin, Torino, ItalyBSc/MA03/2004Pharmaceutical Chemistry and Technologies
    University of Manchester, Manchester, UKMRes12/2006Life Sciences
    University of Manchester, Manchester, UKPhD12/2010Stem Cell Biology
    Collapse Awards and Honors
    European Union2002Socrates Erasmus Program
    The Armourers & Brasiers' Company2009Armourers & Brasiers’ Gauntlet Trust Award
    Marine Biological Laboratory2013Frontiers in Reproduction MBL Scholarship
    International Federation of Placenta Associations2015NIH Young Investigator Award
    International Federation of Placenta Associations 2016Elsevier Award
    Perinatal Research Society 2017PRS Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Interested in early placental development and the trophoblast (placental) stem cells. In particular, the identification of the transcription factor network and signaling pathways for the maintenance of trophoblast stem cells.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Drivers of trophoblast stem/progenitor cell identity in human placenta
    CIRM DISC0-13757Jan 1, 2023 - Jan 31, 2025
    Role: Principal Investigator
    Role of VGLL1 in human placental development and trophoblast specification
    NIH R01HD096260Feb 1, 2019 - Jan 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chronic Villitis as a Distinctive Feature of Placental Injury in Maternal SARS-CoV-2 Infection. Am J Obstet Gynecol. 2024 Apr 03. Gabby LC, Jones CK, McIntyre BB, Manalo Z, Meads M, Pizzo DP, Diaz-Vigil J, Soncin F, Fisch KM, Ramos GA, Jacobs MB, Parast MM. PMID: 38580043.
      View in: PubMed   Mentions:    Fields:    
    2. Conserved and divergent features of trophoblast stem cells. J Mol Endocrinol. 2024 May 01; 72(4). Sah N, Soncin F. PMID: 38276878.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Current Strategies of Modeling Human Trophoblast Using Human Pluripotent Stem Cells in vitro. Curr Protoc. 2023 Oct; 3(10):e875. Cheung VC, Bui T, Soncin F, Bai T, Kessler JA, Parast MM, Horii M. PMID: 37787612; PMCID: PMC10558083.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Corrigendum: Transcriptomic drivers of differentiation, maturation, and polyploidy in human extravillous trophoblast. Front Cell Dev Biol. 2023; 11:1189745. Morey R, Farah O, Kallol S, Requena DF, Meads M, Moretto-Zita M, Soncin F, Laurent LC, Parast MM. PMID: 37057000; PMCID: PMC10086438.
      View in: PubMed   Mentions:
    5. Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2. Stem Cells Dev. 2023 05; 32(9-10):225-236. Kallol S, Martin-Sancho L, Morey R, Aisagbonhi O, Pizzo D, Meads M, Chanda SK, Soncin F. PMID: 36803114; PMCID: PMC10171947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. The role of BMP4 signaling in trophoblast emergence from pluripotency. Cell Mol Life Sci. 2022 Jul 25; 79(8):447. Roberts RM, Ezashi T, Temple J, Owen JR, Soncin F, Parast MM. PMID: 35877048; PMCID: PMC10243463.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Derivation of functional trophoblast stem cells from primed human pluripotent stem cells. Stem Cell Reports. 2022 06 14; 17(6):1303-1317. Soncin F, Morey R, Bui T, Requena DF, Cheung VC, Kallol S, Kittle R, Jackson MG, Farah O, Chousal J, Meads M, Pizzo D, Horii M, Fisch KM, Parast MM. PMID: 35594858; PMCID: PMC9214048.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    8. Role of autocrine bone morphogenetic protein signaling in trophoblast stem cells†. Biol Reprod. 2022 03 19; 106(3):540-550. Au J, Requena DF, Rishik H, Kallol S, Tekkatte C, Farah OA, Kittle R, Meads M, Wakeland A, Soncin F. PMID: 34791028; PMCID: PMC8934699.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast. Front Cell Dev Biol. 2021; 9:702046. Morey R, Farah O, Kallol S, Requena DF, Meads M, Moretto-Zita M, Soncin F, Laurent LC, Parast MM. PMID: 34540826; PMCID: PMC8446284.
      View in: PubMed   Mentions: 15  
    10. Role of Hippo signaling pathway in early placental development. Proc Natl Acad Sci U S A. 2020 08 25; 117(34):20354-20356. Soncin F, Parast MM. PMID: 32788372; PMCID: PMC7456147.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories. Stem Cell Reports. 2019 11 12; 13(5):924-938. D'Antonio-Chronowska A, Donovan MKR, Young Greenwald WW, Nguyen JP, Fujita K, Hashem S, Matsui H, Soncin F, Parast M, Ward MC, Coulet F, Smith EN, Adler E, D'Antonio M, Frazer KA. PMID: 31668852; PMCID: PMC6895695.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    12. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018 01 29; 145(2). Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul Nambi Rajan K, Nelson KK, Chang CW, Moretto-Zita M, Natale DR, Laurent LC, Parast MM. PMID: 29361559; PMCID: PMC5825847.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    13. Sirtuin1 is required for proper trophoblast differentiation and placental development in mice. Placenta. 2018 02; 62:1-8. Arul Nambi Rajan K, Khater M, Soncin F, Pizzo D, Moretto-Zita M, Pham J, Stus O, Iyer P, Tache V, Laurent LC, Parast MM. PMID: 29405961; PMCID: PMC5805473.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017 Apr; 187(4):767-780. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent LC, Parast MM. PMID: 28167044; PMCID: PMC5397702.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    15. Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem. 2015 Dec 11; 290(50):30152-62. Moretto Zita M, Soncin F, Natale D, Pizzo D, Parast M. PMID: 26491013; PMCID: PMC4705987.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci. 2015 Apr; 72(7):1291-302. Soncin F, Natale D, Parast MM. PMID: 25430479; PMCID: PMC4366325.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    17. Novel cell lines isolated from mouse embryonic stem cells exhibiting de novo methylation of the E-cadherin promoter. Stem Cells. 2014 Nov; 32(11):2869-79. Hawkins K, Keramari M, Soncin F, Segal JM, Mohamet L, Miazga N, Ritson S, Bobola N, Merry CL, Ward CM. PMID: 25074424.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state. Development. 2013 Oct; 140(19):3965-76. Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, Loring JF, Crum CP, Laurent LC, Parast MM. PMID: 24004950; PMCID: PMC3775414.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    19. A sensitive green fluorescent protein biomarker of N-glycosylation site occupancy. FASEB J. 2012 Oct; 26(10):4210-7. Losfeld ME, Soncin F, Ng BG, Singec I, Freeze HH. PMID: 22691915; PMCID: PMC3448770.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. E-cadherin acts as a regulator of transcripts associated with a wide range of cellular processes in mouse embryonic stem cells. PLoS One. 2011; 6(7):e21463. Soncin F, Mohamet L, Ritson S, Hawkins K, Bobola N, Zeef L, Merry CL, Ward CM. PMID: 21779327; PMCID: PMC3136471.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. The function of e-cadherin in stem cell pluripotency and self-renewal. Genes (Basel). 2011 Feb 25; 2(1):229-59. Soncin F, Ward CM. PMID: 24710147; PMCID: PMC3924836.
      View in: PubMed   Mentions: 37     Fields:    
    22. Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol. 2010 Nov; 28(11):1187-94. Oldershaw RA, Baxter MA, Lowe ET, Bates N, Grady LM, Soncin F, Brison DR, Hardingham TE, Kimber SJ. PMID: 20967028.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    23. Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal. Stem Cells. 2009 Sep; 27(9):2069-80. Soncin F, Mohamet L, Eckardt D, Ritson S, Eastham AM, Bobola N, Russell A, Davies S, Kemler R, Merry CL, Ward CM. PMID: 19544408.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    24. Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 2007 Dec 01; 67(23):11254-62. Eastham AM, Spencer H, Soncin F, Ritson S, Merry CL, Stern PL, Ward CM. PMID: 18056451.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    25. E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells. Mol Biol Cell. 2007 Aug; 18(8):2838-51. Spencer HL, Eastham AM, Merry CL, Southgate TD, Perez-Campo F, Soncin F, Ritson S, Kemler R, Stern PL, Ward CM. PMID: 17507657; PMCID: PMC1949355.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
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