Farhad Imam

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0734
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    Acutely ill premature and term newborn infants are exposed to environmental perturbations such as high/low oxygen or temperature as part of their disease process. These perturbations can cause cellular damage during a critical time of maturation for the brain and other organs, contributing to disorders such as cerebral palsy, autism and seizures.

    Dr. Imam has established an animal model to study acute and repetitive stress during embryogenesis and have used it to identify novel, conserved stress-protective genes using genetic and genomic strategies. These novel genes may provide additional insight into stress-protective and hypoxia-protective mechanisms, and ultimately therapeutic strategies for acutely ill and/or preterm infants.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanistic Insights into Hypoxic Preconditioning using Genetic and Genomic Approaches in Zebrafish
    NIH/NHLBI K08HL134579Aug 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Trans-illumination of visible light for real-time catheter visualization
    NIH/NCI R43CA162857Sep 16, 2011 - Jun 30, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Marin-Valencia I, Novarino G, Johansen A, Rosti B, Issa MY, Musaev D, Bhat G, Scott E, Silhavy JL, Stanley V, Rosti RO, Gleeson JW, Imam FB, Zaki MS, Gleeson JG. A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly, epilepsy and autistic features. J Med Genet. 2018 Jan; 55(1):48-54. PMID: 28626029.
      View in: PubMed
    2. Han T, Yang CS, Chang KY, Zhang D, Imam FB, Rana TM. Identification of novel genes and networks governing hematopoietic stem cell development. EMBO Rep. 2016 12; 17(12):1814-1828. PMID: 27797851.
      View in: PubMed
    3. Manchenkov T, Pasillas MP, Haddad GG, Imam FB. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 2015 Apr 03; 5(6):1107-16. PMID: 25840431; PMCID: PMC4478541.
    4. Cloete E, Battin MR, Imam FB, Teele RL. Ossification of sacral vertebral bodies in neonates born 24 to 38 weeks' gestational age and its relevance to spinal ultrasonography. Am J Perinatol. 2013 Jun; 30(6):519-22. PMID: 23254382.
      View in: PubMed
    5. Vastenhouw NL, Zhang Y, Woods IG, Imam F, Regev A, Liu XS, Rinn J, Schier AF. Chromatin signature of embryonic pluripotency is established during genome activation. Nature. 2010 Apr 08; 464(7290):922-6. PMID: 20336069; PMCID: PMC2874748.
    6. Raychaudhuri S, Chang JT, Imam F, Altman RB. The computational analysis of scientific literature to define and recognize gene expression clusters. Nucleic Acids Res. 2003 Aug 01; 31(15):4553-60. PMID: 12888516; PMCID: PMC169898.
    7. Arbeitman MN, Furlong EE, Imam F, Johnson E, Null BH, Baker BS, Krasnow MA, Scott MP, Davis RW, White KP. Gene expression during the life cycle of Drosophila melanogaster. Science. 2002 Sep 27; 297(5590):2270-5. PMID: 12351791.
      View in: PubMed
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