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    Farhad Imam

    TitleAssistant Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0734
    CA La Jolla 92093
    Phone858-822-4661
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      Collapse Overview 
      Collapse Overview
      Acutely ill premature and term newborn infants are exposed to environmental perturbations such as high/low oxygen or temperature as part of their disease process. These perturbations can cause cellular damage during a critical time of maturation for the brain and other organs, contributing to disorders such as cerebral palsy, autism and seizures.

      Dr. Imam has established an animal model to study acute and repetitive stress during embryogenesis and have used it to identify novel, conserved stress-protective genes using genetic and genomic strategies. These novel genes may provide additional insight into stress-protective and hypoxia-protective mechanisms, and ultimately therapeutic strategies for acutely ill and/or preterm infants.


      Collapse Research 
      Collapse Research Activities and Funding
      Mechanistic Insights into Hypoxic Preconditioning using Genetic and Genomic Approaches in Zebrafish
      NIH/NHLBI K08HL134579Aug 1, 2016 - Jul 31, 2021
      Role: Principal Investigator
      Trans-illumination of visible light for real-time catheter visualization
      NIH/NCI R43CA162857Sep 16, 2011 - Jun 30, 2013
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Marin-Valencia I, Novarino G, Johansen A, Rosti B, Issa MY, Musaev D, Bhat G, Scott E, Silhavy JL, Stanley V, Rosti RO, Gleeson JW, Imam F, Zaki MS, Gleeson JG. A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly, epilepsy and autistic features. J Med Genet. 2017 Jun 16. PMID: 28626029.
        View in: PubMed
      2. Han T, Yang CS, Chang KY, Zhang D, Imam F, Rana TM. Identification of novel genes and networks governing hematopoietic stem cell development. EMBO Rep. 2016 Dec; 17(12):1814-1828. PMID: 27797851.
        View in: PubMed
      3. Woods IG, Imam F. Transcriptome analysis of severe hypoxic stress during development in zebrafish. Genom Data. 2015 Dec; 6:83-8. PMID: 26697342; PMCID: PMC4664676.
      4. Manchenkov T, Pasillas MP, Haddad GG, Imam F. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 2015 Apr 03; 5(6):1107-16. PMID: 25840431; PMCID: PMC4478541.
      5. Cloete E, Battin MR, Imam F, Teele RL. Ossification of sacral vertebral bodies in neonates born 24 to 38 weeks' gestational age and its relevance to spinal ultrasonography. Am J Perinatol. 2013 Jun; 30(6):519-22. PMID: 23254382.
        View in: PubMed
      6. Vastenhouw NL, Zhang Y, Woods IG, Imam F, Regev A, Liu XS, Rinn J, Schier AF. Chromatin signature of embryonic pluripotency is established during genome activation. Nature. 2010 Apr 08; 464(7290):922-6. PMID: 20336069; PMCID: PMC2874748.
      7. Raychaudhuri S, Chang JT, Imam F, Altman RB. The computational analysis of scientific literature to define and recognize gene expression clusters. Nucleic Acids Res. 2003 Aug 01; 31(15):4553-60. PMID: 12888516; PMCID: PMC169898.
      8. Arbeitman MN, Furlong EE, Imam F, Johnson E, Null BH, Baker BS, Krasnow MA, Scott MP, Davis RW, White KP. Gene expression during the life cycle of Drosophila melanogaster. Science. 2002 Sep 27; 297(5590):2270-5. PMID: 12351791.
        View in: PubMed
      9. Imam F, Sutherland D, Huang W, Krasnow MA. stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells. Genetics. 1999 May; 152(1):307-18. PMID: 10224263; PMCID: PMC1460608.
      10. Bender M, Imam F, Talbot WS, Ganetzky B, Hogness DS. Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell. 1997 Dec 12; 91(6):777-88. PMID: 9413987.
        View in: PubMed
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