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    Evan Snyder

    TitleAssociate Physician
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address200 W. Arbor Drive #8774
    CA San Diego 92103
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      Collapse Research 
      Collapse Research Activities and Funding
      Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
      NIH/NIMH RC2MH090011Sep 30, 2009 - Aug 31, 2012
      Role: Principal Investigator
      Homing of Stem Cells in Stroke Therapeutics
      NIH/NINDS R21NS062428Jun 15, 2009 - Feb 29, 2012
      Role: Co-Principal Investigator
      The Stem Cell Center at The Burnham Institute
      NIH/NIGMS P20GM075059Aug 1, 2005 - Jul 31, 2009
      Role: Principal Investigator
      IMMORTALIZED NEURAL PRECURSORS FOR GENE THERAPY &REPAIR
      NIH/NINDS R01NS034247Sep 1, 1995 - Aug 31, 2001
      Role: Principal Investigator
      IMMORTALIZATION &GRAFTING OF NEURAL PROGENITORS
      NIH/NINDS R01NS033852Sep 30, 1994 - Mar 31, 2001
      Role: Principal Investigator
      USE OF RETROVIRAL VECTORS TO STUDY NEURAL PLASTICITY
      NIH/NINDS K08NS001403Aug 1, 1989 - Jul 31, 1994
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Snyder E. Finding a new purpose for old drugs. Science. 2017 Sep 01; 357(6354):869-870. PMID: 28860370.
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      2. Davies BM, Smith J, Rikabi S, Wartolowska K, Morrey M, French A, MacLaren R, Williams D, Bure K, Pinedo-Villanueva R, Mathur A, Birchall M, Snyder E, Atala A, Reeve B, Brindley D. A quantitative, multi-national and multi-stakeholder assessment of barriers to the adoption of cell therapies. J Tissue Eng. 2017 Jan-Dec; 8:2041731417724413. PMID: 28835816.
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      3. Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder E. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A. 2017 May 30; 114(22):E4462-E4471. PMID: 28500272.
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      4. Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent LC, Elsworth JD, Sladek J, Snyder E, Redmond DE, Kern RA. Neural Stem Cells Derived From Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinsons Disease. Cell Transplant. 2016 Nov; 25(11):1945-1966. PMID: 27931506.
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      5. Garitaonandia I, Gonzalez R, Christiansen-Weber T, Abramihina T, Poustovoitov M, Noskov A, Sherman G, Semechkin A, Snyder E, Kern R. Neural Stem Cell Tumorigenicity and Biodistribution Assessment for Phase I Clinical Trial in Parkinson's Disease. Sci Rep. 2016 Sep 30; 6:34478. PMID: 27686862.
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      6. Ropper AE, Zeng X, Haragopal H, Anderson JE, Aljuboori Z, Han I, Abd-El-Barr M, Lee HJ, Sidman RL, Snyder E, Viapiano MS, Kim SU, Chi JH, Teng YD. Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. Neurosurgery. 2016 Sep; 79(3):481-91. PMID: 26671631.
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      7. Singec I, Crain AM, Hou J, Tobe BT, Talantova M, Winquist AA, Doctor KS, Choy J, Huang X, La Monaca E, Horn DM, Wolf DA, Lipton SA, Gutierrez GJ, Brill LM, Snyder E. Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports. 2016 Sep 13; 7(3):527-42. PMID: 27569059.
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      8. Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent LC, Elsworth JD, Sladek J, Snyder E, Jr DE, Kern RA. Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease. Cell Transplant. 2016 May 20. PMID: 27213850.
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      9. Abelin JG, Patel J, Lu X, Feeney CM, Fagbami L, Creech AL, Hu R, Lam D, Davison D, Pino L, Qiao JW, Kuhn E, Officer A, Li J, Abbatiello S, Subramanian A, Sidman R, Snyder E, Carr SA, Jaffe JD. Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes. Mol Cell Proteomics. 2016 May; 15(5):1622-41. PMID: 26912667.
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      10. Acevedo LM, Lindquist JN, Walsh BM, Sia P, Cimadamore F, Chen C, Denzel M, Pernia CD, Ranscht B, Terskikh A, Snyder E, Cheresh DA. hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature. Stem Cell Reports. 2015 Jun 9; 4(6):1075-88. PMID: 26004631.
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      11. Gonzalez R, Garitaonandia I, Crain A, Poustovoitov M, Abramihina T, Noskov A, Jiang C, Morey R, Laurent LC, Elsworth JD, Snyder E, Redmond DE, Semechkin R. Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease. Cell Transplant. 2015; 24(4):681-90. PMID: 25839189.
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      12. French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder E, Brindley DA. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem Cells Transl Med. 2015 Mar; 4(3):217-23. PMID: 25650438.
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      13. Silva M, Daheron L, Hurley H, Bure K, Barker R, Carr AJ, Williams D, Kim HW, French A, Coffey PJ, Cooper-White JJ, Reeve B, Rao M, Snyder E, Ng KS, Mead BE, Smith JA, Karp JM, Brindley DA, Wall I. Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies. Cell Stem Cell. 2015 Jan 8; 16(1):13-7. PMID: 25575079.
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      14. Huang L, Wong S, Snyder E, Hamblin MH, Lee JP. Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury. Stem Cell Res Ther. 2014; 5(6):129. PMID: 25418536.
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      15. Liu Y, Wu D, Lao D, Peterson C, Hohenstein Elliott KA, Snyder E. Laser-assisted generation of human induced pluripotent stem cells. Curr Protoc Stem Cell Biol. 2014; 31:4A.7.1-4A.7.15. PMID: 25366899.
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      16. Claycomb KI, Winokur PN, Johnson KM, Nicaise AM, Giampetruzzi AW, Sacino AV, Snyder E, Barbarese E, Bongarzone ER, Crocker SJ. Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. J Neuropathol Exp Neurol. 2014 Oct; 73(10):964-74. PMID: 25192051.
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      17. Davies BM, Rikabi S, French A, Pinedo-Villanueva R, Morrey ME, Wartolowska K, Judge A, MacLaren RE, Mathur A, Williams DJ, Wall I, Birchall M, Reeve B, Atala A, Barker RW, Cui Z, Furniss D, Bure K, Snyder E, Karp JM, Price A, Carr A, Brindley DA. Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. J Tissue Eng. 2014; 5:2041731414551764. PMID: 25383173.
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      18. Franklin RJ, Snyder E. Special issue on stem cells: "the end of the beginning". Exp Neurol. 2014 Oct; 260:1-2. PMID: 24950181.
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      19. Song RS, Carroll JM, Acevedo L, Wu D, Liu Y, Snyder E. Generation, Expansion, and Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) Derived From the Umbilical Cords of Newborns. Curr Protoc Stem Cell Biol. 2014; 29:1C.16.1-1C.16.13. PMID: 24838913.
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      20. Wakeman DR, Redmond DE, Dodiya HB, Sladek JR, Leranth C, Teng YD, Samulski RJ, Snyder E. Human Neural Stem Cells Survive Long Term in the Midbrain of Dopamine-Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target. Stem Cells Transl Med. 2014 Jun; 3(6):692-701. PMID: 24744393.
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      21. Ashwal S, Ghosh N, Turenius CI, Dulcich M, Denham CM, Tone B, Hartman R, Snyder E, Obenaus A. Reparative effects of neural stem cells in neonatal rats with hypoxic-ischemic injury are not influenced by host sex. Pediatr Res. 2014 May; 75(5):603-11. PMID: 24463490.
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      22. Goncharova V, Das S, Niles W, Schraufstatter I, Wong AK, Povaly T, Wakeman D, Miller L, Snyder E, Khaldoyanidi SK. Homing of neural stem cells from the venous compartment into a brain infarct does not involve conventional interactions with vascular endothelium. Stem Cells Transl Med. 2014 Feb; 3(2):229-40. PMID: 24396034.
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      23. Brindley DA, French A, Suh J, Roberts M, Davies B, Pinedo-Villanueva R, Wartolowska K, Rooke K, Kramm A, Judge A, Morrey M, Chandra A, Hurley H, Grover L, Bingham I, Siegel B, Rattley MS, Buckler RL, McKeon D, Krumholz K, Hook L, May M, Rikabi S, Pigott R, Morys M, Sabokbar A, Titus E, Laabi Y, Lemaitre G, Zahkia R, Sipp D, Horne R, Bravery C, Williams D, Wall I, Snyder E, Karp JM, Barker RW, Bure K, Carr AJ, Reeve B. The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev. 2013 Dec; 22 Suppl 1:63-72. PMID: 24304079.
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      24. Tobe BT, Brandel MG, Nye JS, Snyder E. Implications and limitations of cellular reprogramming for psychiatric drug development. Exp Mol Med. 2013; 45:e59. PMID: 24232258.
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      25. Oh IH, Snyder E. Special feature on stem cells: current research and future prospects. Exp Mol Med. 2013; 45:e63. PMID: 24232262.
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      26. Olee T, Grogan SP, Lotz MK, Colwell CW, D'Lima DD, Snyder E. Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells. Tissue Eng Part A. 2014 Feb; 20(3-4):683-92. PMID: 24028447.
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      27. Smith GA, Snyder E. Two cells are better than one: optimizing stem cell survival by co-grafting "helper" cells that offer regulated trophic support. Exp Neurol. 2013 Sep; 247:751-4. PMID: 23856435.
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      28. Li J, Yu L, Gu X, Ma Y, Pasqualini R, Arap W, Snyder E, Sidman RL. Tissue plasminogen activator regulates Purkinje neuron development and survival. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2410-9. PMID: 23674688.
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      29. Bignone PA, Krupa RA, Sternberg H, Funk WD, Snyder E, West MD, Larocca D. Identification of human embryonic progenitor cell targeting peptides using phage display. PLoS One. 2013; 8(3):e58200. PMID: 23483995.
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      30. Ijichi K, Brown GD, Moore CS, Lee JP, Winokur PN, Pagarigan R, Snyder E, Bongarzone ER, Crocker SJ. MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology. Glia. 2013 May; 61(5):765-77. PMID: 23404611.
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      31. Gonzalez R, Garitaonandia I, Abramihina T, Wambua GK, Ostrowska A, Brock M, Noskov A, Boscolo FS, Craw JS, Laurent LC, Snyder E, Semechkin RA. Deriving dopaminergic neurons for clinical use. A practical approach. Sci Rep. 2013; 3:1463. PMID: 23492920.
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      32. Hou J, Tobe BT, Lo F, Blethrow JD, Crain AM, Wolf DA, Snyder E, Singec I, Brill LM. Combined total proteomic and phosphoproteomic analysis of human pluripotent stem cells. Methods Mol Biol. 2013; 1029:163-89. PMID: 23756949.
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      33. Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D, Han I, Maragakis NJ, Lládo J, Erkmen K, Redmond DE, Sidman RL, Przedborski S, Rothstein JD, Brown RH, Snyder E. Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Sci Transl Med. 2012 Dec 19; 4(165):165ra164. PMID: 23253611.
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      34. Newton IG, Plaisted WC, Messina-Graham S, Abrahamsson Schairer AE, Shih AY, Snyder E, Jamieson CH, Mattrey RF. Optical imaging of progenitor cell homing to patient-derived tumors. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):525-36. PMID: 22991319.
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      35. Ghosh N, Yuan X, Turenius CI, Tone B, Ambadipudi K, Snyder E, Obenaus A, Ashwal S. Automated core-penumbra quantification in neonatal ischemic brain injury. J Cereb Blood Flow Metab. 2012 Dec; 32(12):2161-70. PMID: 22929436.
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      36. Snyder E, Teng YD. Stem cells and spinal cord repair. N Engl J Med. 2012 May 17; 366(20):1940-2. PMID: 22591301.
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      37. Parsons JF, Smotrich DB, Gonzalez R, Snyder E, Moore DA, Parsons XH. Defining Conditions for Sustaining Epiblast Pluripotence Enables Direct Induction of Clinically-Suitable Human Myocardial Grafts from Biologics-Free Human Embryonic Stem Cells. J Clin Exp Cardiolog. 2012 Apr 25; S9. PMID: 22905333.
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      38. Sternberg H, Murai JT, Erickson IE, Funk WD, Das S, Wang Q, Snyder E, Chapman KB, Vangsness CT, West MD. A human embryonic stem cell-derived clonal progenitor cell line with chondrogenic potential and markers of craniofacial mesenchyme. Regen Med. 2012 Jul; 7(4):481-501. PMID: 22519755.
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      39. Tobe BT, Hou J, Crain AM, Singec I, Snyder E, Brill LM. Phosphoproteomic analysis: an emerging role in deciphering cellular signaling in human embryonic stem cells and their differentiated derivatives. Stem Cell Rev. 2012 Mar; 8(1):16-31. PMID: 22009073.
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      40. Arthur JR, Lee JP, Snyder E, Seyfried TN. Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice. Neurochem Res. 2012 Jun; 37(6):1335-43. PMID: 22367451.
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      41. Teng YD, Yu D, Ropper AE, Li J, Kabatas S, Wakeman DR, Wang J, Sullivan MP, Redmond DE, Langer R, Snyder E, Sidman RL. Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research. Curr Neuropharmacol. 2011 Dec; 9(4):574-85. PMID: 22654717.
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      42. Parsons XH, Teng YD, Parsons JF, Snyder E, Smotrich DB, Moore DA. Efficient derivation of human cardiac precursors and cardiomyocytes from pluripotent human embryonic stem cells with small molecule induction. J Vis Exp. 2011; (57):e3274. PMID: 22083019.
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      43. Parsons XH, Teng YD, Parsons JF, Snyder E, Smotrich DB, Moore DA. Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction. J Vis Exp. 2011; (56):e3273. PMID: 22064669.
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      44. Serre A, Snyder E, Mallet J, Buchet D. Overexpression of basic helix-loop-helix transcription factors enhances neuronal differentiation of fetal human neural progenitor cells in various ways. Stem Cells Dev. 2012 Mar 1; 21(4):539-53. PMID: 21561385.
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      45. Tobe BT, Snyder E, Nye JS. Modeling complex neuropsychiatric disorders with human induced pluripotent stem cells. Curr Opin Pharmacol. 2011 Oct; 11(5):521-7. PMID: 21723195.
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      46. Katkov II, Kan NG, Cimadamore F, Nelson B, Snyder E, Terskikh AV. DMSO-Free Programmed Cryopreservation of Fully Dissociated and Adherent Human Induced Pluripotent Stem Cells. Stem Cells Int. 2011; 2011:981606. PMID: 21716669.
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      47. Snyder E. The intricate dance between repair and inflammation: introduction to special issue. Exp Neurol. 2011 Jul; 230(1):1-2. PMID: 21596040.
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      48. Snyder E. The risk of putting something where it does not belong: mesenchymal stem cells produce masses in the brain. Exp Neurol. 2011 Jul; 230(1):75-7. PMID: 21420402.
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      49. Gonzalez R, Lee JW, Snyder E, Schultz PG. Dorsomorphin promotes human embryonic stem cell self-renewal. Angew Chem Int Ed Engl. 2011 Apr 4; 50(15):3439-41. PMID: 21384475.
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      50. Kim KS, Lee HJ, Jeong HS, Li J, Teng YD, Sidman RL, Snyder E, Kim SU. Self-renewal induced efficiently, safely, and effective therapeutically with one regulatable gene in a human somatic progenitor cell. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4876-81. PMID: 21378266.
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      51. Parsons XH, Teng YD, Moore DA, Snyder E. Patents on Technologies of Human Tissue and Organ Regeneration from Pluripotent Human Embryonic Stem Cells. Recent Pat Regen Med. 2011; 1(2):142-163. PMID: 23355961.
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      52. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder E, Haddad GG. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
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      53. Grammatopoulos TN, Jones SM, Yoshimura M, Hoover BR, Das M, Snyder E, Larson GA, Zahniser NR, Tabakoff B, Zawada WM. Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption. Stem Cell Res Ther. 2010; 1(5):36. PMID: 21122109.
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      54. Obenaus A, Dilmac N, Tone B, Tian HR, Hartman R, Digicaylioglu M, Snyder E, Ashwal S. Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury. Ann Neurol. 2011 Feb; 69(2):282-91. PMID: 21387373.
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      55. Curchoe CL, Maurer J, McKeown SJ, Cattarossi G, Cimadamore F, Nilbratt M, Snyder E, Bronner-Fraser M, Terskikh AV. Early acquisition of neural crest competence during hESCs neuralization. PLoS One. 2010; 5(11):e13890. PMID: 21085480.
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      56. Li J, Gu X, Ma Y, Calicchio ML, Kong D, Teng YD, Yu L, Crain AM, Vartanian TK, Pasqualini R, Arap W, Libermann TA, Snyder E, Sidman RL. Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-?B signaling. Neuron. 2010 Oct 6; 68(1):45-60. PMID: 20920790.
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      57. Vaziri H, Chapman KB, Guigova A, Teichroeb J, Lacher MD, Sternberg H, Singec I, Briggs L, Wheeler J, Sampathkumar J, Gonzalez R, Larocca D, Murai J, Snyder E, Andrews WH, Funk WD, West MD. Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming. Regen Med. 2010 May; 5(3):345-63. PMID: 20230312.
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      58. Chernov AV, Baranovskaya S, Golubkov VS, Wakeman DR, Snyder E, Williams R, Strongin AY. Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens, and related genes in cancer. J Biol Chem. 2010 Jun 18; 285(25):19647-59. PMID: 20404328.
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      59. Lindquist JN, Cheresh DA, Snyder E. Derivation of vasculature from embryonic stem cells. Curr Protoc Stem Cell Biol. 2010 Mar; Chapter 1:Unit 1F.9. PMID: 20200855.
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      60. Jäderstad J, Jäderstad LM, Li J, Chintawar S, Salto C, Pandolfo M, Ourednik V, Teng YD, Sidman RL, Arenas E, Snyder E, Herlenius E. Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5184-9. PMID: 20147621.
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      61. Gonzalez R, Jennings LL, Knuth M, Orth AP, Klock HE, Ou W, Feuerhelm J, Hull MV, Koesema E, Wang Y, Zhang J, Wu C, Cho CY, Su AI, Batalov S, Chen H, Johnson K, Laffitte B, Nguyen DG, Snyder E, Schultz PG, Harris JL, Lesley SA. Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3552-7. PMID: 20133595.
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      62. Katz J, Keenan B, Snyder E. Culture and manipulation of neural stem cells. Adv Exp Med Biol. 2010; 671:13-22. PMID: 20455492.
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      63. Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder E, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A. The transcriptional network for mesenchymal transformation of brain tumours. Nature. 2010 Jan 21; 463(7279):318-25. PMID: 20032975.
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      64. Ourednik V, Ourednik J, Xu Y, Zhang Y, Lynch WP, Snyder E, Schachner M. Cross-talk between stem cells and the dysfunctional brain is facilitated by manipulating the niche: evidence from an adhesion molecule. Stem Cells. 2009 Nov; 27(11):2846-56. PMID: 19785036.
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      65. Espinosa-Jeffrey A, Wakeman DR, Kim SU, Snyder E, de Vellis J. Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturation. Curr Protoc Stem Cell Biol. 2009 Sep; Chapter 2:Unit 2D.4. PMID: 19725014.
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      66. Jandial R, Snyder E. A safer stem cell: on guard against cancer. Nat Med. 2009 Sep; 15(9):999-1001. PMID: 19734873.
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      67. Jeyakumar M, Lee JP, Sibson NR, Lowe JP, Stuckey DJ, Tester K, Fu G, Newlin R, Smith DA, Snyder E, Platt FM. Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease. Stem Cells. 2009 Sep; 27(9):2362-70. PMID: 19591217.
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      68. Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder E, Ding S. Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell. 2009 Aug 7; 5(2):204-13. PMID: 19664994.
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      69. Lee JP, Tsai DJ, In Park K, Harvey AR, Snyder E. The dynamics of long-term transgene expression in engrafted neural stem cells. J Comp Neurol. 2009 Jul 1; 515(1):83-92. PMID: 19399895.
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      70. Magge SN, Malik SZ, Royo NC, Chen HI, Yu L, Snyder E, O'Rourke DM, Watson DJ. Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. J Neurosci Res. 2009 May 15; 87(7):1547-55. PMID: 19125409.
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      71. Wakeman DR, Hofmann MR, Redmond DE, Teng YD, Snyder E. Long-term multilayer adherent network (MAN) expansion, maintenance, and characterization, chemical and genetic manipulation, and transplantation of human fetal forebrain neural stem cells. Curr Protoc Stem Cell Biol. 2009 May; Chapter 2:Unit2D.3. PMID: 19455542.
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      72. Ashwal S, Obenaus A, Snyder E. Neuroimaging as a basis for rational stem cell therapy. Pediatr Neurol. 2009 Mar; 40(3):227-36. PMID: 19218036.
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      73. Staquicini FI, Dias-Neto E, Li J, Snyder E, Sidman RL, Pasqualini R, Arap W. Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2903-8. PMID: 19193855.
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      74. Parsons XH, Teng YD, Snyder E. Important precautions when deriving patient-specific neural elements from pluripotent cells. Cytotherapy. 2009; 11(7):815-24. PMID: 19903095.
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      75. Katz J, Krueger J, Felding-Habermann B, Snyder E. Maintaining and engineering neural stem cells for delivery of genetically encoded therapy to brain tumors. Methods Mol Biol. 2009; 568:249-59. PMID: 19582432.
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      76. Neville CM, Huang AY, Shyu JY, Snyder E, Hadlock TA, Sundback CA. Neural precursor cell lines promote neurite branching. Int J Neurosci. 2009; 119(1):15-39. PMID: 19116829.
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      77. Wang L, Shi J, van Ginkel FW, Lan L, Niemeyer G, Martin DR, Snyder E, Cox NR. Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2. Exp Neurol. 2009 Mar; 216(1):177-83. PMID: 19109951.
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      78. De Filippis L, Ferrari D, Rota Nodari L, Amati B, Snyder E, Vescovi AL. Immortalization of human neural stem cells with the c-myc mutant T58A. PLoS One. 2008; 3(10):e3310. PMID: 18836552.
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      79. Fauza DO, Jennings RW, Teng YD, Snyder E. Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifida. Surgery. 2008 Sep; 144(3):367-73. PMID: 18707035.
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      80. Singec I, Snyder E. Inflammation as a matchmaker: revisiting cell fusion. Nat Cell Biol. 2008 May; 10(5):503-5. PMID: 18454127.
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      81. Gonzalez R, Loring JF, Snyder E. Preparation of autogenic human feeder cells for growth of human embryonic stem cells. Curr Protoc Stem Cell Biol. 2008 Mar; Chapter 1:Unit 1C.5.1-1C.5.15. PMID: 18770638.
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      82. Bjugstad KB, Teng YD, Redmond DE, Elsworth JD, Roth RH, Cornelius SK, Snyder E, Sladek JR. Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease. Exp Neurol. 2008 Jun; 211(2):362-9. PMID: 18394605.
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      83. Jandial R, Singec I, Ames CP, Snyder E. Genetic modification of neural stem cells. Mol Ther. 2008 Mar; 16(3):450-7. PMID: 18253153.
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      84. Jandial R, Aryan HE, Park J, Taylor WT, Snyder E. Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge. Neurosurg Focus. 2008; 24(3-4):E21. PMID: 18341398.
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      85. Lee JP, McKercher S, Muller FJ, Snyder E. Neural stem cell transplantation in mouse brain. Curr Protoc Neurosci. 2008 Jan; Chapter 3:Unit 3.10. PMID: 18428671.
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      86. Jandial R, U H, Levy ML, Snyder E. Brain tumor stem cells and the tumor microenvironmen. Neurosurg Focus. 2008; 24(3-4):E27. PMID: 18341404.
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      87. Singec I, Snyder E. Quo vadis brain repair? A long axonal journey in the adult CNS. Cell Stem Cell. 2007 Oct 11; 1(4):355-6. PMID: 18371370.
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      88. Wang L, Martin DR, Baker HJ, Zinn KR, Kappes JC, Ding H, Gentry AS, Harper S, Snyder E, Cox NR. Neural progenitor cell transplantation and imaging in a large animal model. Neurosci Res. 2007 Nov; 59(3):327-40. PMID: 17897743.
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      89. Redmond DE, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR, Sidman RL, Snyder E. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12175-80. PMID: 17586681.
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      90. Parker MA, Corliss DA, Gray B, Anderson JK, Bobbin RP, Snyder E, Cotanche DA. Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hear Res. 2007 Oct; 232(1-2):29-43. PMID: 17659854.
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      91. De Filippis L, Lamorte G, Snyder E, Malgaroli A, Vescovi AL. A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes. Stem Cells. 2007 Sep; 25(9):2312-21. PMID: 17556596.
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      92. Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, Dwek RA, Schwartz P, Tong G, Wenger D, Lipton SA, Seyfried TN, Platt FM, Snyder E. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med. 2007 Apr; 13(4):439-47. PMID: 17351625.
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      93. Sidman RL, Li J, Stewart GR, Clarke J, Yang W, Snyder E, Shihabuddin LS. Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice. Brain Res. 2007 Apr 6; 1140:195-204. PMID: 17289003.
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      94. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder E, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan; 25(1):100-6. PMID: 17206138.
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      95. Ahmad I, Hunter RE, Flax JD, Snyder E, Erickson RP. Neural stem cell implantation extends life in Niemann-Pick C1 mice. J Appl Genet. 2007; 48(3):269-72. PMID: 17666780.
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      96. Singec I, Jandial R, Crain A, Nikkhah G, Snyder E. The leading edge of stem cell therapeutics. Annu Rev Med. 2007; 58:313-28. PMID: 17100553.
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      97. Yu JJ, Sun X, Yuan X, Lee JW, Snyder E, Yu JS. Immunomodulatory neural stem cells for brain tumour therapy. Expert Opin Biol Ther. 2006 Dec; 6(12):1255-62. PMID: 17223735.
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      98. Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder E, Lo EH, Weissleder R, Schellingerhout D. Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging. Radiology. 2006 Dec; 241(3):822-30. PMID: 17114629.
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      99. Teng YD, Liao WL, Choi H, Konya D, Sabharwal S, Langer R, Sidman RL, Snyder E, Frontera WR. Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells. Regen Med. 2006 Nov; 1(6):763-76. PMID: 17465758.
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      100. Mueller FJ, Serobyan N, Schraufstatter IU, DiScipio R, Wakeman D, Loring JF, Snyder E, Khaldoyanidi SK. Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins. Stem Cells. 2006 Nov; 24(11):2367-72. PMID: 17071855.
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      101. Singec I, Knoth R, Meyer RP, Maciaczyk J, Volk B, Nikkhah G, Frotscher M, Snyder E. Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology. Nat Methods. 2006 Oct; 3(10):801-6. PMID: 16990812.
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      102. Li J, Imitola J, Snyder E, Sidman RL. Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets. J Neurosci. 2006 Jul 26; 26(30):7839-48. PMID: 16870729.
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      103. Katkov II, Kim MS, Bajpai R, Altman YS, Mercola M, Loring JF, Terskikh AV, Snyder E, Levine F. Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology. 2006 Oct; 53(2):194-205. PMID: 16839540.
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      104. Wakeman DR, Crain AM, Snyder E. Large animal models are critical for rationally advancing regenerative therapies. Regen Med. 2006 Jul; 1(4):405-13. PMID: 17465832.
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      105. Park KI, Hack MA, Ourednik J, Yandava B, Flax JD, Stieg PE, Gullans S, Jensen FE, Sidman RL, Ourednik V, Snyder E. Acute injury directs the migration, proliferation, and differentiation of solid organ stem cells: evidence from the effect of hypoxia-ischemia in the CNS on clonal "reporter" neural stem cells. Exp Neurol. 2006 May; 199(1):156-78. PMID: 16737696.
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      106. Taylor RM, Lee JP, Palacino JJ, Bower KA, Li J, Vanier MT, Wenger DA, Sidman RL, Snyder E. Intrinsic resistance of neural stem cells to toxic metabolites may make them well suited for cell non-autonomous disorders: evidence from a mouse model of Krabbe leukodystrophy. J Neurochem. 2006 Jun; 97(6):1585-99. PMID: 16805770.
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      107. Park KI, Himes BT, Stieg PE, Tessler A, Fischer I, Snyder E. Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury. Exp Neurol. 2006 May; 199(1):179-90. PMID: 16714016.
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      108. Kim HT, Kim IS, Lee IS, Lee JP, Snyder E, Park KI. Human neurospheres derived from the fetal central nervous system are regionally and temporally specified but are not committed. Exp Neurol. 2006 May; 199(1):222-35. PMID: 16714017.
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      109. Yip S, Sabetrasekh R, Sidman RL, Snyder E. Neural stem cells as novel cancer therapeutic vehicles. Eur J Cancer. 2006 Jun; 42(9):1298-308. PMID: 16697638.
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      110. Li J, Ma Y, Teng YD, Zheng K, Vartanian TK, Snyder E, Sidman RL. Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7847-52. PMID: 16682647.
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      111. Snyder E. Special issue: the intersection of stem/progenitor cell biology and hypoxic-ischemic cerebral injury/stroke. Exp Neurol. 2006 May; 199(1):1-4. PMID: 16798271.
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      112. Snyder E, Hinman LM, Kalichman MW. Can science resolve the ethical impasse in stem cell research? Nat Biotechnol. 2006 Apr; 24(4):397-400. PMID: 16601717.
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      113. Bakshi A, Shimizu S, Keck CA, Cho S, LeBold DG, Morales D, Arenas E, Snyder E, Watson DJ, McIntosh TK. Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. Eur J Neurosci. 2006 Apr; 23(8):2119-34. PMID: 16630059.
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      114. Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol. 2006 Mar; 26(5):1666-78. PMID: 16478988.
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      115. Snyder E, Loring JF. Beyond fraud--stem-cell research continues. N Engl J Med. 2006 Jan 26; 354(4):321-4. PMID: 16436761.
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      116. Souza GR, Christianson DR, Staquicini FI, Ozawa MG, Snyder E, Sidman RL, Miller JH, Arap W, Pasqualini R. Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1215-20. PMID: 16434473.
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      117. Teng YD, Choi H, Huang W, Onario RC, Frontera WR, Snyder E, Sabharwal S. Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis. Neurosci Lett. 2006 Apr 10-17; 397(1-2):155-8. PMID: 16388902.
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      118. Müller FJ, Snyder E, Loring JF. Gene therapy: can neural stem cells deliver? Nat Rev Neurosci. 2006 Jan; 7(1):75-84. PMID: 16371952.
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      119. Rajan P, Snyder E. Neural stem cells and their manipulation. Methods Enzymol. 2006; 419:23-52. PMID: 17141050.
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      120. Kalichman MW, Hinman LM, Snyder E. Exploring common ground in the stem cell ethical debate--a perspective for scientists: introduction to this special issue of stem cell reviews. Stem Cell Rev. 2005 Dec; 1(4):285-6. PMID: 17142867.
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      121. Bakshi A, Keck CA, Koshkin VS, LeBold DG, Siman R, Snyder E, McIntosh TK. Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. Brain Res. 2005 Dec 14; 1065(1-2):8-19. PMID: 16309635.
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      122. Snyder E, Loring JF. A role for stem cell biology in the physiological and pathological aspects of aging. J Am Geriatr Soc. 2005 Sep; 53(9 Suppl):S287-91. PMID: 16131354.
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      123. Parker MA, Anderson JK, Corliss DA, Abraria VE, Sidman RL, Park KI, Teng YD, Cotanche DA, Snyder E. Expression profile of an operationally-defined neural stem cell clone. Exp Neurol. 2005 Aug; 194(2):320-32. PMID: 15992799.
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      124. Boockvar JA, Schouten J, Royo N, Millard M, Spangler Z, Castelbuono D, Snyder E, O'Rourke D, McIntosh T. Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells. Neurosurgery. 2005; 56(1):163-71; discussion 171. PMID: 15617599.
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      125. Bjugstad KB, Redmond DE, Teng YD, Elsworth JD, Roth RH, Blanchard BC, Snyder E, Sladek JR. Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures. Cell Transplant. 2005; 14(4):183-92. PMID: 15929553.
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      126. Ryu MY, Lee MA, Ahn YH, Kim KS, Yoon SH, Snyder E, Cho KG, Kim SU. Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian rats. Cell Transplant. 2005; 14(4):193-202. PMID: 15929554.
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      127. Mueller FJ, McKercher SR, Imitola J, Loring JF, Yip S, Khoury SJ, Snyder E. At the interface of the immune system and the nervous system: how neuroinflammation modulates the fate of neural progenitors in vivo. Ernst Schering Res Found Workshop. 2005; (53):83-114. PMID: 16315610.
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      128. Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder E, Khoury SJ. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18117-22. PMID: 15608062.
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      129. Yan J, Welsh AM, Bora SH, Snyder E, Koliatsos VE. Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cord. J Comp Neurol. 2004 Nov 29; 480(1):101-14. PMID: 15514921.
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      130. Schouten JW, Fulp CT, Royo NC, Saatman KE, Watson DJ, Snyder E, Trojanowski JQ, Prockop DJ, Maas AI, McIntosh TK. A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. J Neurotrauma. 2004 Nov; 21(11):1501-38. PMID: 15684646.
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      131. Lladó J, Haenggeli C, Maragakis NJ, Snyder E, Rothstein JD. Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Mol Cell Neurosci. 2004 Nov; 27(3):322-31. PMID: 15519246.
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      132. Imitola J, Park KI, Teng YD, Nisim S, Lachyankar M, Ourednik J, Mueller FJ, Yiou R, Atala A, Sidman RL, Tuszynski M, Khoury SJ, Snyder E. Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci. 2004 May 29; 359(1445):823-37. PMID: 15293810.
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      133. Imitola J, Comabella M, Chandraker AK, Dangond F, Sayegh MH, Snyder E, Khoury SJ. Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli. Am J Pathol. 2004 May; 164(5):1615-25. PMID: 15111308.
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      134. Snyder E, Daley GQ, Goodell M. Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res. 2004 Apr 15; 76(2):157-68. PMID: 15048913.
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      135. Rothstein JD, Snyder E. Reality and immortality--neural stem cells for therapies. Nat Biotechnol. 2004 Mar; 22(3):283-5. PMID: 14990948.
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      136. Mellough CB, Cui Q, Spalding KL, Symons NA, Pollett MA, Snyder E, Macklis JD, Harvey AR. Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells. Exp Neurol. 2004 Mar; 186(1):6-19. PMID: 14980806.
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      137. Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder E, Eichler ME, Friedlander RM. Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9):3071-6. PMID: 14981254.
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      138. Mautes AE, Liu J, Brandewiede J, Manville J, Snyder E, Schachner M. Regional energy metabolism following short-term neural stem cell transplantation into the injured spinal cord. J Mol Neurosci. 2004; 24(2):227-36. PMID: 15456936.
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      139. Boockvar JA, Kapitonov D, Kapoor G, Schouten J, Counelis GJ, Bogler O, Snyder E, McIntosh TK, O'Rourke DM. Constitutive EGFR signaling confers a motile phenotype to neural stem cells. Mol Cell Neurosci. 2003 Dec; 24(4):1116-30. PMID: 14697673.
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      140. Lerro KA, Medoff E, Wu Y, Seropian SE, Snyder E, Krause D, Cooper DL. A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agents. Bone Marrow Transplant. 2003 Dec; 32(12):1113-7. PMID: 14647264.
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      141. Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R. In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther. 2003 Sep 1; 14(13):1247-54. PMID: 12952596.
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      142. Imitola J, Snyder E, Khoury SJ. Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis. Physiol Genomics. 2003 Aug 15; 14(3):171-97. PMID: 12923300.
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      143. Lu P, Jones LL, Snyder E, Tuszynski MH. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol. 2003 Jun; 181(2):115-29. PMID: 12781986.
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      144. Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder E. Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer J. 2003 May-Jun; 9(3):189-204. PMID: 12952304.
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      145. Daley GQ, Goodell MA, Snyder E. Realistic prospects for stem cell therapeutics. Hematology Am Soc Hematol Educ Program. 2003; 398-418. PMID: 14633792.
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      146. Ourednik J, Ourednik V, Lynch WP, Schachner M, Snyder E. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat Biotechnol. 2002 Nov; 20(11):1103-10. PMID: 12379867.
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      147. Park KI, Teng YD, Snyder E. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol. 2002 Nov; 20(11):1111-7. PMID: 12379868.
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      148. Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, Raghupathi R, Lenzlinger PM, Lifshitz J, Boockvar J, Neugebauer E, Snyder E, McIntosh TK. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery. 2002 Oct; 51(4):1043-52; discussion 1052-4. PMID: 12234415.
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      149. Yang M, Stull ND, Berk MA, Snyder E, Iacovitti L. Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Exp Neurol. 2002 Sep; 177(1):50-60. PMID: 12429210.
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      150. Snyder E, Park KI. Limitations in brain repair. Nat Med. 2002 Sep; 8(9):928-30. PMID: 12205449.
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      151. Park KI, Ourednik J, Ourednik V, Taylor RM, Aboody KS, Auguste KI, Lachyankar MB, Redmond DE, Snyder E. Global gene and cell replacement strategies via stem cells. Gene Ther. 2002 May; 9(10):613-24. PMID: 12032707.
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      152. Zlomanczuk P, Mrugala M, de la Iglesia HO, Ourednik V, Quesenberry PJ, Snyder E, Schwartz WJ. Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus. Exp Neurol. 2002 Apr; 174(2):162-8. PMID: 11922658.
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      153. Teng YD, Lavik EB, Qu X, Park KI, Ourednik J, Zurakowski D, Langer R, Snyder E. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):3024-9. PMID: 11867737.
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      154. Lavik E, Teng YD, Snyder E, Langer R. Seeding neural stem cells on scaffolds of PGA, PLA, and their copolymers. Methods Mol Biol. 2002; 198:89-97. PMID: 11951644.
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      155. Kosaras B, Snyder E. Electron microscopy and lac-Z labeling. Methods Mol Biol. 2002; 198:157-75. PMID: 11951619.
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      156. Park KI, Lachyankar M, Nissim S, Snyder E. Neural stem cells for CNS repair: state of the art and future directions. Adv Exp Med Biol. 2002; 506(Pt B):1291-6. PMID: 12614070.
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      157. Akerud P, Canals JM, Snyder E, Arenas E. Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease. J Neurosci. 2001 Oct 15; 21(20):8108-18. PMID: 11588183.
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      158. Himes BT, Liu Y, Solowska JM, Snyder E, Fischer I, Tessler A. Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats. J Neurosci Res. 2001 Sep 15; 65(6):549-64. PMID: 11550223.
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      159. Ourednik V, Ourednik J, Flax JD, Zawada WM, Hutt C, Yang C, Park KI, Kim SU, Sidman RL, Freed CR, Snyder E. Segregation of human neural stem cells in the developing primate forebrain. Science. 2001 Sep 7; 293(5536):1820-4. PMID: 11474066.
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      160. Snyder E. What kind of information technology training do you need and where can you find it? Biomed Instrum Technol. 2001 May-Jun; 35(3):203-6. PMID: 11395980.
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      161. Berger CL, Xu AL, Hanlon D, Lee C, Schechner J, Glusac E, Christensen I, Snyder E, Holloway V, Tigelaar R, Edelson RL. Induction of human tumor-loaded dendritic cells. Int J Cancer. 2001 Feb 15; 91(4):438-47. PMID: 11251964.
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      162. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder E. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A. 2000 Nov 7; 97(23):12846-51. PMID: 11070094.
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      163. Doering LC, Snyder E. Cholinergic expression by a neural stem cell line grafted to the adult medial septum/diagonal band complex. J Neurosci Res. 2000 Sep 15; 61(6):597-604. PMID: 10972956.
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      164. Sanchez-Ramos J, Song S, Dailey M, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Zigova T, Sanberg PR, Snyder E. The X-gal caution in neural transplantation studies. Cell Transplant. 2000 Sep-Oct; 9(5):657-67. PMID: 11144962.
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      165. Sanchez-Ramos J, Song S, Dailey M, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Zigova T, Sanberg PR, Snyder E. Article Commentary: The X-gal Caution in Neural Transplantation Studies. Cell Transplant. 2000 Sep; 9(5):657-667. PMID: 28880667.
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      166. Davenport RW, Lanuza M, Kim S, Jia M, Snyder E, Nelson PG. Thrombin action decreases acetylcholine receptor aggregate number and stability in cultured mouse myotubes. Brain Res Dev Brain Res. 2000 Aug 30; 122(2):119-23. PMID: 10960680.
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      167. Snyder E, Vescovi AL. The possibilities/perplexities of stem cells. Nat Biotechnol. 2000 Aug; 18(8):827-8. PMID: 10932148.
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      168. Herrlinger U, Woiciechowski C, Sena-Esteves M, Aboody KS, Jacobs AH, Rainov NG, Snyder E, Breakefield XO. Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas. Mol Ther. 2000 Apr; 1(4):347-57. PMID: 10933953.
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      169. Ourednik V, Ourednik J, Park KI, Teng YD, Aboody KA, Auguste KI, Taylor RM, Tate BA, Snyder E. Neural stem cells are uniquely suited for cell replacement and gene therapy in the CNS. Novartis Found Symp. 2000; 231:242-62; discussion 262-9, 302-6. PMID: 11131542.
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      170. Villa A, Snyder E, Vescovi A, Martínez-Serrano A. Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp Neurol. 2000 Jan; 161(1):67-84. PMID: 10683274.
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      171. Clineschmidt CM, Williams RD, Snyder E, Adamsons IA. A randomized trial in patients inadequately controlled with timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Ophthalmology. 1999 Dec; 106(12 Suppl):17-24. PMID: 10598693.
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      172. Rubio FJ, Kokaia Z, del Arco A, García-Simón MI, Snyder E, Lindvall O, Satrústegui J, Martínez-Serrano A. BDNF gene transfer to the mammalian brain using CNS-derived neural precursors. Gene Ther. 1999 Nov; 6(11):1851-66. PMID: 10602381.
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      173. Rowitch DH, S-Jacques B, Lee SM, Flax JD, Snyder E, McMahon AP. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci. 1999 Oct 15; 19(20):8954-65. PMID: 10516314.
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      174. Poulsen DJ, Favara C, Snyder E, Portis J, Chesebro B. Increased neurovirulence of polytropic mouse retroviruses delivered by inoculation of brain with infected neural stem cells. Virology. 1999 Oct 10; 263(1):23-9. PMID: 10544079.
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      175. Ourednik V, Ourednik J, Park KI, Snyder E. Neural stem cells -- a versatile tool for cell replacement and gene therapy in the central nervous system. Clin Genet. 1999 Oct; 56(4):267-78. PMID: 10636444.
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      176. Lynch WP, Sharpe AH, Snyder E. Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. J Virol. 1999 Aug; 73(8):6841-51. PMID: 10400782.
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      177. Park KI, Liu S, Flax JD, Nissim S, Stieg PE, Snyder E. Transplantation of neural progenitor and stem cells: developmental insights may suggest new therapies for spinal cord and other CNS dysfunction. J Neurotrauma. 1999 Aug; 16(8):675-87. PMID: 10511240.
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      178. Liu Y, Himes BT, Solowska J, Moul J, Chow SY, Park KI, Tessler A, Murray M, Snyder E, Fischer I. Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus. Exp Neurol. 1999 Jul; 158(1):9-26. PMID: 10448414.
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      179. Vescovi AL, Snyder E. Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo. Brain Pathol. 1999 Jul; 9(3):569-98. PMID: 10416994.
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      180. Wagner J, Akerud P, Castro DS, Holm PC, Canals JM, Snyder E, Perlmann T, Arenas E. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat Biotechnol. 1999 Jul; 17(7):653-9. PMID: 10404157.
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      181. Yandava BD, Billinghurst LL, Snyder E. "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):7029-34. PMID: 10359833.
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      182. Snyder E, Perrotta P, Rinder H, Baril L, Nichol J, Gilligan D. Effect of recombinant human megakaryocyte growth and development factor coupled with polyethylene glycol on the platelet storage lesion. Transfusion. 1999 Mar; 39(3):258-64. PMID: 10204587.
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      183. Burtness BA, Psyrri A, Rose M, D'Andrea E, Staugaard-Hahn C, Henderson-Bakas M, Clark MB, Mechanic S, Krause D, Snyder E, Cooper RB, Abrantes J, Corringham R, Deisseroth A, Cooper DL. A phase I study of paclitaxel for mobilization of peripheral blood progenitor cells. Bone Marrow Transplant. 1999 Feb; 23(4):311-5. PMID: 10100573.
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      184. Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13765-70. PMID: 9811875.
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      185. Flax JD, Aurora S, Yang C, Simonin C, Wills AM, Billinghurst LL, Jendoubi M, Sidman RL, Wolfe JH, Kim SU, Snyder E. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol. 1998 Nov; 16(11):1033-9. PMID: 9831031.
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      186. Clineschmidt CM, Williams RD, Snyder E, Adamsons IA. A randomized trial in patients inadequately controlled with timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Dorzolamide-Timolol Combination Study Group. Ophthalmology. 1998 Oct; 105(10):1952-9. PMID: 9787369.
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      187. Billinghurst LL, Taylor RM, Snyder E. Remyelination: cellular and gene therapy. Semin Pediatr Neurol. 1998 Sep; 5(3):211-28. PMID: 9777679.
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      188. Belury MA, Moya-Camarena SY, Sun H, Snyder E, Davis JW, Cunningham ML, Vanden Heuvel JP. Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver. Toxicol Appl Pharmacol. 1998 Aug; 151(2):254-61. PMID: 9707502.
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      189. Magriples U, Bernstein P, Snyder E, Copel JA. Can risk factor screening predict hepatitis C antibody reactivity? Am J Perinatol. 1998 Jun; 15(6):395-8. PMID: 9722062.
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      190. Hansen AR, Snyder E. Medical management of neonatal posthemorrhagic hydrocephalus. Neurosurg Clin N Am. 1998 Jan; 9(1):95-104. PMID: 9405767.
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      191. Inoue H, Ishii H, Alder H, Snyder E, Druck T, Huebner K, Croce CM. Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14584-9. PMID: 9405656.
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      192. Aboody-Guterman KS, Pechan PA, Rainov NG, Sena-Esteves M, Jacobs A, Snyder E, Wild P, Schraner E, Tobler K, Breakefield XO, Fraefel C. Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo. Neuroreport. 1997 Dec 1; 8(17):3801-8. PMID: 9427374.
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      193. Plotkin MD, Snyder E, Hebert SC, Delpire E. Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain. J Neurobiol. 1997 Nov 20; 33(6):781-95. PMID: 9369151.
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      194. Snyder E, Edwards J. Troubleshooting EEG noise. Biomed Instrum Technol. 1997 Nov-Dec; 31(6):632-3. PMID: 9426903.
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      195. Rosario CM, Yandava BD, Kosaras B, Zurakowski D, Sidman RL, Snyder E. Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action. Development. 1997 Nov; 124(21):4213-24. PMID: 9334270.
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      196. Snyder E, Yoon C, Flax JD, Macklis JD. Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11663-8. PMID: 9326667.
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      197. Taylor RM, Snyder E. Widespread engraftment of neural progenitor and stem-like cells throughout the mouse brain. Transplant Proc. 1997 Feb-Mar; 29(1-2):845-7. PMID: 9123550.
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      198. Snyder E, Park KI, Flax JD, Liu S, Rosario CM, Yandava BD, Aurora S. Potential of neural "stem-like" cells for gene therapy and repair of the degenerating central nervous system. Adv Neurol. 1997; 72:121-32. PMID: 8993691.
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      199. Snyder E, Senut MC. The use of nonneuronal cells for gene delivery. Neurobiol Dis. 1997; 4(2):69-102. PMID: 9331899.
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      200. Snyder E, Fisher LJ. Gene therapy in neurology. Curr Opin Pediatr. 1996 Dec; 8(6):558-68. PMID: 9018439.
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      201. Lynch WP, Snyder E, Qualtiere L, Portis JL, Sharpe AH. Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains. J Virol. 1996 Dec; 70(12):8896-907. PMID: 8971019.
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      202. Tucker DM, Leckman JF, Scahill L, Wilf GE, LaCamera R, Cardona L, Cohen P, Heidmann S, Goldstein J, Judge J, Snyder E, Bult A, Peterson BS, King R, Lombroso P. A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. J Am Acad Child Adolesc Psychiatry. 1996 Dec; 35(12):1684-91. PMID: 8973076.
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      203. Snyder E, Wolfe JH. Central nervous system cell transplantation: a novel therapy for storage diseases? Curr Opin Neurol. 1996 Apr; 9(2):126-36. PMID: 8782981.
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      204. Lacorazza HD, Flax JD, Snyder E, Jendoubi M. Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells. Nat Med. 1996 Apr; 2(4):424-9. PMID: 8597952.
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      205. Whittemore SR, Snyder E. Physiological relevance and functional potential of central nervous system-derived cell lines. Mol Neurobiol. 1996 Feb; 12(1):13-38. PMID: 8732538.
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      206. Snyder E. Immortalized neural stem cells: insights into development; prospects for gene therapy and repair. Proc Assoc Am Physicians. 1995 Jul; 107(2):195-204. PMID: 8624853.
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      207. Snyder E, Taylor RM, Wolfe JH. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature. 1995 Mar 23; 374(6520):367-70. PMID: 7885477.
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      208. Snyder E, Macklis JD. Multipotent neural progenitor or stem-like cells may be uniquely suited for therapy for some neurodegenerative conditions. Clin Neurosci. 1995-1996; 3(5):310-6. PMID: 8914798.
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      209. Snyder E. Grafting immortalized neurons to the CNS. Curr Opin Neurobiol. 1994 Oct; 4(5):742-51. PMID: 7849531.
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      210. Kitchens DL, Snyder E, Gottlieb DI. FGF and EGF are mitogens for immortalized neural progenitors. J Neurobiol. 1994 Jul; 25(7):797-807. PMID: 8089657.
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      211. Murphy S, Rebulla P, Bertolini F, Holme S, Moroff G, Snyder E, Stromberg R. In vitro assessment of the quality of stored platelet concentrates. The BEST (Biomedical Excellence for Safer Transfusion) Task Force of the International Society of Blood Transfusion. Transfus Med Rev. 1994 Jan; 8(1):29-36. PMID: 8136605.
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      212. Wolfe JH, Taylor RM, Sands MS, Haskins ME, Patterson DF, Snyder E. Mucopolysaccharidosis type VII as a model system for gene transfer to the central nervous system. Gene Ther. 1994; 1 Suppl 1:S55. PMID: 8542400.
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      213. Snyder E. Neural transplantation: an approach to cellular plasticity in the developing central nervous system. Semin Perinatol. 1992 Apr; 16(2):106-21. PMID: 1636125.
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      214. Snyder E, Deitcher DL, Walsh C, Arnold-Aldea S, Hartwieg EA, Cepko CL. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell. 1992 Jan 10; 68(1):33-51. PMID: 1732063.
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      215. Turner DL, Snyder E, Cepko CL. Lineage-independent determination of cell type in the embryonic mouse retina. Neuron. 1990 Jun; 4(6):833-45. PMID: 2163263.
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      216. Ryder EF, Snyder E, Cepko CL. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J Neurobiol. 1990 Mar; 21(2):356-75. PMID: 2307979.
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      217. Romero R, Snyder E, Scott D, Oyarzun E, Hobbins JC, Duffy TP. Beta-thromboglobulin during normal pregnancy, labor, and puerperium. Am J Perinatol. 1988 Apr; 5(2):109-12. PMID: 2964825.
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      218. Buchholz DH, Lin A, Snyder E, McCullough J, Porten J, Anderson M, Smith J, Dalmasso A, Helphingstine C, Path M. Plasma separation using a hollow fiber membrane device. Transfusion. 1986 Mar-Apr; 26(2):145-50. PMID: 3952789.
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      219. Snyder E, Kim SU. Insulin: is it a nerve survival factor? Brain Res. 1980 Sep 8; 196(2):565-71. PMID: 6994854.
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      220. Snyder E, Kim SU. Hormonal requirements for neuronal survival in culture. Neurosci Lett. 1979 Aug; 13(3):225-30. PMID: 119183.
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