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    Eugene Yeo

    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Collapse Overview 
      Collapse Overview
      Understanding how genes are regulated and coordinated is of fundamental significance in biomedical sciences. RNA binding proteins (RBPs) are an unexplored frontier of regulated gene expression, even though their misregulation leads to critical human diseases. I am a leader in the development of computational and experimental approaches to understand mechanistic details of how RBPs control post-transcriptional regulatory networks in development and disease (neurodegeneration). My ongoing research program focuses on how specific RBPs and their regulated RNA targets are necessary for the survival and function of pluripotent stem cells and the central nervous system. I leverage computational concepts from my background in engineering and computational neuroscience to develop creative methods for deriving meaning out of highly complex datasets and integrate many different types of information to achieve clear understanding of the underlying problem. My lab is reputed to generate genome-wide data of the highest quality coupled with rigorous analyses. Using human patient-derived stem cell models, mice and patient post-mortem samples, we delve deep into mechanistic validations of our predictions, forging actionable links between basic biology and medicine. In proposed research, I am dedicated to exploring post-transcriptional gene regulation but at the level of single pluripotent stem cells and neurons. We will develop novel scalable methodologies to test hypotheses of variation and cell-type specific heterogeneity in RNA processing. We are committed to developing RNA-sensitive nanotechnologies that utilize differences in RNA content in cells to alter cellular behavior, linking our efforts to deeply understand RNA biology with engineering applications derived from that knowledge.

      Research Focus Areas:

    • Developmental Biology

    • Genetics and Genomics

    • Gene Expression and Regulation

    • Neurodevelopment and Neurodegenerative Disease

    • Stem Cell Biology

    • Systems Biology

    • Collapse Research 
      Collapse Research Activities and Funding
      Application of RNA-targeting Cas9 to Fuchs' dystrophy
      NIH/NEI R01EY029166Apr 1, 2018 - Mar 31, 2022
      Role: Principal Investigator
      A Comprehensive Functional Map of Human Protein-RNA Interactions
      NIH/NHGRI U41HG009889Feb 5, 2018 - Jan 31, 2022
      Role: Co-Principal Investigator
      Therapeutic strategies for microsatellite expansion diseases using RNA-targeting CRISPR/Cas
      NIH/NINDS R01NS103172Sep 22, 2017 - May 31, 2022
      Role: Principal Investigator
      Dissecting splicing factor mutations in iPSCs
      NIH/NHLBI R01HL137219Apr 5, 2017 - Jan 31, 2021
      Role: Co-Principal Investigator
      Using single-cell RNA-seq to interrogate host immunity to pathogens
      NIH/NIAID R01AI123202Sep 23, 2016 - Aug 31, 2021
      Role: Principal Investigator
      Reconstruction of cardiovascular regulatory networks from large-scale single-cell analyses of cardiovascular lineages
      NIH/NICHD R01HD085902Mar 1, 2016 - Feb 28, 2021
      Role: Principal Investigator
      Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
      NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
      Role: Principal Investigator
      Defining the messenger RNP code in the brain
      NIH/NINDS R01NS075449Feb 15, 2012 - Jan 31, 2017
      Role: Principal Investigator
      NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
      Role: Principal Investigator
      Genomic Measurement of Alternative Splicing
      NIH/NIGMS R01GM084317Jan 1, 2009 - Dec 31, 2013
      Role: Principal Investigator
      Functional RNA elements in the human genome
      NIH/NHGRI R01HG004659Jun 1, 2008 - Jun 30, 2020
      Role: Principal Investigator
      Administrative Core
      NIH/NIMH U19MH-01
      Role: Co-Investigator

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