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Eugene Tkachenko

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0726
La Jolla CA 92093
Phone858-822-6492
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    Collapse Research 
    Collapse Research Activities and Funding
    Endothelial Mechanotaxis During Development
    NIH/NHLBI R56HL124195Sep 1, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Visualization of shear stress-induced endothelial cell signaling.
    NIH/NHLBI F32HL094012Aug 1, 2008 - Jul 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Weijts B, Tkachenko E, Traver D, Groisman A. A Four-Well Dish for High-Resolution Longitudinal Imaging of the Tail and Posterior Trunk of Larval Zebrafish. Zebrafish. 2017 10; 14(5):489-491. PMID: 28118101.
      View in: PubMed
    2. Vertelov G, Gutierrez E, Lee SA, Ronan E, Groisman A, Tkachenko E. Rigidity of silicone substrates controls cell spreading and stem cell differentiation. Sci Rep. 2016 Sep 21; 6:33411. PMID: 27651230; PMCID: PMC5030667.
    3. Tkachenko E, Rawson R, La E, Doherty TA, Baum R, Cavagnero K, Miyanohara A, Dohil R, Kurten RC, Aceves SS. Rigid substrate induces esophageal smooth muscle hypertrophy and eosinophilic esophagitis fibrotic gene expression. J Allergy Clin Immunol. 2016 Apr; 137(4):1270-1272.e1. PMID: 26542032; PMCID: PMC4826849 [Available on 04/01/17].
    4. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710; PMCID: PMC3798183.
    5. Tkachenko E, Tse D, Sideleva O, Deharvengt SJ, Luciano MR, Xu Y, McGarry CL, Chidlow J, Pilch PF, Sessa WC, Toomre DK, Stan RV. Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells. PLoS One. 2012; 7(3):e32655. PMID: 22403691; PMCID: PMC3293851.
    6. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg MH, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031; PMCID: PMC3178539.
    7. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420; PMCID: PMC3746034.
    8. Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010 Oct; 137(20):3449-58. PMID: 20843856; PMCID: PMC2947757.
    9. Tkachenko E, Gutierrez E, Ginsberg MH, Groisman A. An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip. 2009 Apr 21; 9(8):1085-95. PMID: 19350090; PMCID: PMC2742503.
    10. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell. 2008 Nov; 19(11):4930-41. PMID: 18784251; PMCID: PMC2575143.
    11. Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res. 2008 Jul 18; 103(2):177-85. PMID: 18583710; PMCID: PMC2669779.
    12. FĂ©ral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH. CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol. 2007 Aug 13; 178(4):701-11. PMID: 17682053; PMCID: PMC2064475.
    13. Geddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle. 2007 Feb 15; 6(4):455-60. PMID: 17312391.
      View in: PubMed
    14. Tkachenko E, Lutgens E, Stan RV, Simons M. Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway. J Cell Sci. 2004 Jul 01; 117(Pt 15):3189-99. PMID: 15226395.
      View in: PubMed
    15. Stan RV, Tkachenko E, Niesman IR. PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms. Mol Biol Cell. 2004 Aug; 15(8):3615-30. PMID: 15155804; PMCID: PMC491823.
    16. Horowitz A, Tkachenko E, Simons M. Fibroblast growth factor-specific modulation of cellular response by syndecan-4. J Cell Biol. 2002 May 13; 157(4):715-25. PMID: 12011116; PMCID: PMC2173870.
    17. Tkachenko E, Simons M. Clustering induces redistribution of syndecan-4 core protein into raft membrane domains. J Biol Chem. 2002 May 31; 277(22):19946-51. PMID: 11889131.
      View in: PubMed