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A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex. J Immunol. 2021 Nov 22.
Mantuano E, Azmoon P, Banki MA, Sigurdson CJ, Campana WM, Gonias SL. PMID: 34810220.
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PubMed Mentions:
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A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. J Biol Chem. 2020 10 09; 295(41):14178-14188.
Mantuano E, Azmoon P, Banki MA, Lam MS, Sigurdson CJ, Gonias SL. PMID: 32788217.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. J Neuroinflammation. 2019 Dec 06; 16(1):257.
Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E. PMID: 31810478.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages. PLoS One. 2019; 14(11):e0224738.
Das L, Azmoon P, Banki MA, Mantuano E, Gonias SL. PMID: 31697716.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue plasminogen activator. J Neurochem. 2020 02; 152(4):468-481.
Mattei V, Manganelli V, Martellucci S, Capozzi A, Mantuano E, Longo A, Ferri A, Garofalo T, Sorice M, Misasi R. PMID: 31602645.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. J Leukoc Biol. 2019 04; 105(4):729-740.
Zalfa C, Azmoon P, Mantuano E, Gonias SL. PMID: 30690783; PMCID: PMC6430673.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci. 2018 07 26; 131(14).
Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E. PMID: 29930084; PMCID: PMC6080607.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 02 14; 8(1):2982.
Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL. PMID: 29445239; PMCID: PMC5813209.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PLoS One. 2017; 12(10):e0186649.
Gonias SL, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS. PMID: 29088295.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 09 14; 130(11):1364-1374.
Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL. PMID: 28684538.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311.
Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM. PMID: 27824728.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci. 2016 10; 76:42-51.
Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E, Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E. PMID: 27565578; PMCID: PMC5056852.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1369-74.
Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL, Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL. PMID: 26787872; PMCID: PMC4747752.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015 Sep 15; 128(18):3478-88.
Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL, Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL. PMID: 26272917; PMCID: PMC4594737.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013; 8(11):e81081.
Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE, Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE. PMID: 24312263; PMCID: PMC3842329.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013 Nov 22; 288(47):34009-34018.
Mantuano E, Lam MS, Gonias SL, Mantuano E, Lam MS, Gonias SL. PMID: 24129569; PMCID: PMC3837140.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. PLoS One. 2013; 8(9):e75497.
Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM, Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM. PMID: 24086544; PMCID: PMC3781060.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci. 2013 Mar 27; 33(13):5590-602.
Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM, Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. PMID: 23536074; PMCID: PMC3837698.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. J Cell Sci. 2013 Jan 01; 126(Pt 1):209-20.
Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL, Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL. PMID: 23132925; PMCID: PMC3603516.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis. Anticancer Agents Med Chem. 2012 Jul; 12(6):653-62.
Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R, Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R. PMID: 22263796.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85.
Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM, Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM. PMID: 21940431; PMCID: PMC3188465.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem. 2010 May 07; 285(19):14259-66.
Mantuano E, Jo M, Gonias SL, Campana WM, Mantuano E, Jo M, Gonias SL, Campana WM. PMID: 20197276; PMCID: PMC2863187.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface. Glia. 2010 Mar; 58(4):399-409.
Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM, Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM. PMID: 19705458; PMCID: PMC2807473.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009 Apr 28; 2(68):ra18.
Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL, Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. PMID: 19401592; PMCID: PMC2696635.
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PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
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The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci. 2008 Nov 05; 28(45):11571-82.
Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM, Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM. PMID: 18987193; PMCID: PMC3837707.
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PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. J Nutr. 2008 Jul; 138(7):1360-4.
Gallo D, Zannoni GF, De Stefano I, Mosca M, Ferlini C, Mantuano E, Scambia G, Gallo D, Zannoni GF, De Stefano I, Mosca M, Ferlini C, Mantuano E, Scambia G. PMID: 18567761.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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17beta-Estradiol and soy phytochemicals selectively induce a type 2 polarization in mesenteric lymph nodes of ovariectomized rats. Menopause. 2008 Jul-Aug; 15(4 Pt 1):718-25.
Gallo D, Battaglia A, Mantuano E, Travaglia D, De Stefano I, Buzzonetti A, Scambia G, Gallo D, Battaglia A, Mantuano E, Travaglia D, De Stefano I, Buzzonetti A, Scambia G. PMID: 18520337.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008 Jul 18; 283(29):19904-11.
Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL, Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. PMID: 18499670; PMCID: PMC2459272.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer. Endocr Relat Cancer. 2007 Jun; 14(2):317-24.
Gallo D, Mantuano E, Fabrizi M, Ferlini C, Mozzetti S, De Stefano I, Scambia G, Gallo D, Mantuano E, Fabrizi M, Ferlini C, Mozzetti S, De Stefano I, Scambia G. PMID: 17639047.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII. Eur J Med Chem. 2005 Jun; 40(6):521-8.
Calderone V, Giorgi I, Livi O, Martinotti E, Mantuano E, Martelli A, Nardi A, Calderone V, Giorgi I, Livi O, Martinotti E, Mantuano E, Martelli A, Nardi A. PMID: 15922836.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells