Elisabetta Mantuano

Title(s)	ASSOC PROJ SCI-FY NON REP, Pathology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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An LRP1-binding motif in cellular prion protein replicates cell-signaling activities of the full-length protein. JCI Insight. 2023 08 08; 8(15). Mantuano E, Zampieri C, Azmoon P, Gunner CB, Heye KR, Gonias SL. PMID: 37368488; PMCID: PMC10445690.

View in: PubMed Mentions: Fields:
Med Medicine (General)
Translation:Animals Cells
An antibody that targets cell-surface glucose-regulated protein-78 inhibits expression of inflammatory cytokines and plasminogen activator inhibitors by macrophages. J Cell Biochem. 2023 05; 124(5):743-752. Gunner CB, Azmoon P, Mantuano E, Das L, Zampieri C, Pizzo SV, Gonias SL. PMID: 36947703; PMCID: PMC10200756.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Cel Cell Biology
Translation:Humans Cells
The LRP1/CD91 ligands, tissue-type plasminogen activator, α2-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling. Sci Rep. 2022 Oct 20; 12(1):17594. Mantuano E, Azmoon P, Banki MA, Gunner CB, Gonias SL. PMID: 36266319; PMCID: PMC9585055.

View in: PubMed Mentions: 4 Fields:
Sci Science
Translation:Humans
Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system. J Biol Chem. 2022 03; 298(3):101642. Gonias SL, Banki MA, Azmoon P, Romero HK, Sigurdson CJ, Mantuano E, Campana WM. PMID: 35090893; PMCID: PMC8861162.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex. J Immunol. 2022 01 01; 208(1):85-96. Mantuano E, Azmoon P, Banki MA, Sigurdson CJ, Campana WM, Gonias SL. PMID: 34810220; PMCID: PMC8702456.

View in: PubMed Mentions: 5 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. J Biol Chem. 2020 10 09; 295(41):14178-14188. Mantuano E, Azmoon P, Banki MA, Lam MS, Sigurdson CJ, Gonias SL. PMID: 32788217; PMCID: PMC7549038.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry
Translation:Animals Cells
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. J Neuroinflammation. 2019 Dec 06; 16(1):257. Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E. PMID: 31810478; PMCID: PMC6896679.

View in: PubMed Mentions: 7 Fields:
Neu Neurology
Translation:Animals Cells
Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages. PLoS One. 2019; 14(11):e0224738. Das L, Azmoon P, Banki MA, Mantuano E, Gonias SL. PMID: 31697716; PMCID: PMC6837328.

View in: PubMed Mentions: 12 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue plasminogen activator. J Neurochem. 2020 02; 152(4):468-481. Mattei V, Manganelli V, Martellucci S, Capozzi A, Mantuano E, Longo A, Ferri A, Garofalo T, Sorice M, Misasi R. PMID: 31602645.

View in: PubMed Mentions: 15 Fields:
Che Chemistry Neu Neurology
Translation:Humans Cells
Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. J Leukoc Biol. 2019 04; 105(4):729-740. Zalfa C, Azmoon P, Mantuano E, Gonias SL. PMID: 30690783; PMCID: PMC6430673.

View in: PubMed Mentions: 13 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci. 2018 07 26; 131(14). Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E. PMID: 29930084; PMCID: PMC6080607.

View in: PubMed Mentions: 7 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 02 14; 8(1):2982. Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL. PMID: 29445239; PMCID: PMC5813209.

View in: PubMed Mentions: 27 Fields:
Sci Science
Translation:Humans Animals Cells
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PLoS One. 2017; 12(10):e0186649. Gonias SL, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS. PMID: 29088295; PMCID: PMC5663383.

View in: PubMed Mentions: 24 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 09 14; 130(11):1364-1374. Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL. PMID: 28684538; PMCID: PMC5600142.

View in: PubMed Mentions: 36 Fields:
Hem Hematology
Translation:Humans Animals Cells
Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017 04; 31(4):1744-1755. Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL. PMID: 28073836; PMCID: PMC5349802.

View in: PubMed Mentions: 14 Fields:
Bio Biology Phy Physiology
Translation:Animals Cells
Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311. Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM. PMID: 27824728; PMCID: PMC5123743.

View in: PubMed Mentions: 10 Fields:
Neu Neurology
Translation:Animals Cells
The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci. 2016 10; 76:42-51. Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E. PMID: 27565578; PMCID: PMC5056852.

View in: PubMed Mentions: 15 Fields:
Cel Cell Biology Mol Molecular Biology Neu Neurology
Translation:Animals Cells
LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1369-74. Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL. PMID: 26787872; PMCID: PMC4747752.

View in: PubMed Mentions: 67 Fields:
Sci Science
Translation:Animals Cells
The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015 Sep 15; 128(18):3478-88. Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL. PMID: 26272917; PMCID: PMC4594737.

View in: PubMed Mentions: 32 Fields:
Cel Cell Biology
Translation:Animals Cells
Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013; 8(11):e81081. Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE. PMID: 24312263; PMCID: PMC3842329.

View in: PubMed Mentions: 22 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013 Nov 22; 288(47):34009-34018. Mantuano E, Lam MS, Gonias SL. PMID: 24129569; PMCID: PMC3837140.

View in: PubMed Mentions: 54 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. PLoS One. 2013; 8(9):e75497. Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM. PMID: 24086544; PMCID: PMC3781060.

View in: PubMed Mentions: 11 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci. 2013 Mar 27; 33(13):5590-602. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. PMID: 23536074; PMCID: PMC3837698.

View in: PubMed Mentions: 38 Fields:
Neu Neurology
Translation:Animals Cells
LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. J Cell Sci. 2013 Jan 01; 126(Pt 1):209-20. Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL. PMID: 23132925; PMCID: PMC3603516.

View in: PubMed Mentions: 41 Fields:
Cel Cell Biology
Translation:Animals Cells
A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis. Anticancer Agents Med Chem. 2012 Jul; 12(6):653-62. Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R. PMID: 22263796.

View in: PubMed Mentions: 8 Fields:
Ant Antineoplastic Agents Che Chemistry
Translation:Humans Cells
The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM. PMID: 21940431; PMCID: PMC3188465.

View in: PubMed Mentions: 33 Fields:
Neu Neurology
Translation:Animals Cells
Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem. 2010 May 07; 285(19):14259-66. Mantuano E, Jo M, Gonias SL, Campana WM. PMID: 20197276; PMCID: PMC2863187.

View in: PubMed Mentions: 46 Fields:
Bio Biochemistry
Translation:Animals Cells
Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface. Glia. 2010 Mar; 58(4):399-409. Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM. PMID: 19705458; PMCID: PMC2807473.

View in: PubMed Mentions: 11 Fields:
Neu Neurology
Translation:Animals Cells
Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009 Apr 28; 2(68):ra18. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. PMID: 19401592; PMCID: PMC2696635.

View in: PubMed Mentions: 80 Fields:
Cel Cell Biology Phy Physiology Sci Science
Translation:Animals Cells
The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci. 2008 Nov 05; 28(45):11571-82. Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM. PMID: 18987193; PMCID: PMC3837707.

View in: PubMed Mentions: 96 Fields:
Neu Neurology
Translation:Animals Cells
Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. J Nutr. 2008 Jul; 138(7):1360-4. Gallo D, Zannoni GF, De Stefano I, Mosca M, Ferlini C, Mantuano E, Scambia G. PMID: 18567761.

View in: PubMed Mentions: 13 Fields:
Nut Nutritional Sciences
Translation:Humans Animals Cells
17beta-Estradiol and soy phytochemicals selectively induce a type 2 polarization in mesenteric lymph nodes of ovariectomized rats. Menopause. 2008 Jul-Aug; 15(4 Pt 1):718-25. Gallo D, Battaglia A, Mantuano E, Travaglia D, De Stefano I, Buzzonetti A, Scambia G. PMID: 18520337.

View in: PubMed Mentions: 3 Fields:
Gyn Gynecology
Translation:Animals Cells
Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008 Jul 18; 283(29):19904-11. Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. PMID: 18499670; PMCID: PMC2459272.

View in: PubMed Mentions: 37 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer. Endocr Relat Cancer. 2007 Jun; 14(2):317-24. Gallo D, Mantuano E, Fabrizi M, Ferlini C, Mozzetti S, De Stefano I, Scambia G. PMID: 17639047.

View in: PubMed Mentions: 1 Fields:
End Endocrinology Neo Neoplasms
Translation:Humans Animals
Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII. Eur J Med Chem. 2005 Jun; 40(6):521-8. Calderone V, Giorgi I, Livi O, Martinotti E, Mantuano E, Martelli A, Nardi A. PMID: 15922836.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Animals Cells