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    Dong-er Zhang

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0815
    CA La Jolla 92093
    Phone858-822-5372
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      Collapse Research 
      Collapse Research Activities and Funding
      CSF2 receptor mediated actions in t(8;21) leukemia
      NIH/NCI R01CA192924Feb 13, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Synergestic roles of SRSF2 and RUNX1 in blood cell development and pathology
      NIH/NIDDK R01DK098808Sep 16, 2013 - Jun 30, 2018
      Role: Principal Investigator
      ISG15 and protein ISGylation in Cancer
      NIH/NCI R01CA177305Mar 1, 2013 - Feb 28, 2018
      Role: Principal Investigator
      International RUNX Workshop
      NIH/NCI R13CA159538Jul 1, 2011 - Dec 31, 2011
      Role: Principal Investigator
      Cancer Researchers in Nanotechnology (CRIN)
      NIH/NCI T32CA153915Sep 3, 2010 - Apr 30, 2022
      Role: Principal Investigator
      UBP43 in Hematopoiesis
      NIH/NHLBI R01HL091549Sep 15, 2008 - Aug 31, 2014
      Role: Principal Investigator
      FASEB Conference-Hematological Malignancies
      NIH/NCI R13CA117424Jul 22, 2005 - Jun 30, 2010
      Role: Principal Investigator
      Mechanism of Interferon Response and Resistance in CML
      NIH/NCI R01CA102625Jul 16, 2004 - Jun 30, 2009
      Role: Principal Investigator
      Molecular Mechanism of Leukemogenesis Involving AML1-ETO
      NIH/NCI R01CA104509Dec 1, 2003 - Jun 30, 2020
      Role: Principal Investigator
      Role of Ubiquitin Like Protein ISG15 Conjugation
      NIH/NIGMS R01GM066955Dec 1, 2002 - Jun 30, 2012
      Role: Principal Investigator
      t(8;21) and SON in Blood Cell Proliferation and Differentiation
      NIH/NCI R01CA096735Jul 1, 2002 - Nov 30, 2014
      Role: Principal Investigator
      UBP43 in Hematopoiesis
      NIH/NCI R01CA079849Oct 25, 1999 - Mar 31, 2009
      Role: Principal Investigator
      INTERACTING FACTORS IN HEMATOPOIESIS AND LEUKEMIA
      NIH P01CA072009Sep 15, 1997 - Apr 30, 2008
      Role: Co-Investigator
      Comprehensive Biology: Exploiting the Yeast Genome
      NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
      Role: Co-Investigator
      CD14 REGULATION BY MONOCYTE DIFFERENTIATION &CYTOKINES
      NIH/NCI R29CA059589Jul 1, 1994 - Jun 30, 2000
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Weng S, Stoner SA, Zhang D. Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies. Oncotarget. 2016 Sep 15. PMID: 27655702.
        View in: PubMed
      2. Qiu J, Zhou B, Thol F, Zhou Y, Chen L, Shao C, DeBoever C, Hou J, Li H, Chaturvedi A, Ganser A, Bejar R, Zhang D, Fu XD, Heuser M. Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators. RNA. 2016 Oct; 22(10):1535-49. PMID: 27492256.
        View in: PubMed
      3. Fan JB, Miyauchi-Ishida S, Arimoto K, Liu D, Yan M, Liu CW, Gyorffy B, Zhang D. Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14313-8. PMID: 26515094; PMCID: PMC4655505.
      4. Fan JB, Arimoto K, Motamedchaboki K, Yan M, Wolf DA, Zhang D. Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis. Sci Rep. 2015 Jul 30; 5:12704. PMID: 26226047; PMCID: PMC4520236.
      5. Komeno Y, Huang YJ, Qiu J, Lin L, Xu Y, Zhou Y, Chen L, Monterroza DD, Li H, DeKelver RC, Yan M, Fu XD, Zhang D. SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing. Mol Cell Biol. 2015 Sep 01; 35(17):3071-82. PMID: 26124281; PMCID: PMC4525309.
      6. Arimoto K, Hishiki T, Kiyonari H, Abe T, Cheng C, Yan M, Fan JB, Futakuchi M, Tsuda H, Murakami Y, Suzuki H, Zhang D, Shimotohno K. Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles. J Interferon Cytokine Res. 2015 May; 35(5):351-8. PMID: 25406959; PMCID: PMC4426318.
      7. Lam K, Muselman A, Du R, Harada Y, Scholl AG, Yan M, Matsuura S, Weng S, Harada H, Zhang D. Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice. Blood. 2014 Oct 02; 124(14):2203-12. PMID: 25150295; PMCID: PMC4183983.
      8. Arimoto K, Burkart C, Yan M, Ran D, Weng S, Zhang D. Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation. Mol Cell Biol. 2014 Oct; 34(20):3843-54. PMID: 25113560; PMCID: PMC4187709.
      9. Arimoto KI, Weng S, Zhang D. Plakophilin-2 induced EGFR phosphorylation: a focus on the intracellular activators of EGFR. Receptors Clin Investig. 2014; 2(1):e485. PMID: 25995992.
        View in: PubMed
      10. DeKelver RC, Lewin B, Lam K, Komeno Y, Yan M, Rundle C, Lo MC, Zhang D. Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia. PLoS Genet. 2013; 9(10):e1003765. PMID: 24130502; PMCID: PMC3794898.
      11. Fang RH, Hu CM, Chen KN, Luk BT, Carpenter CW, Gao W, Li S, Zhang D, Lu W, Zhang L. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale. 2013 Oct 07; 5(19):8884-8. PMID: 23907698; PMCID: PMC3831007.
      12. Burkart C, Arimoto K, Tang T, Cong X, Xiao N, Liu YC, Kotenko SV, Ellies LG, Zhang D. Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-? and elevated secretion of Cxcl10. EMBO Mol Med. 2013 Jul; 5(7):1035-50. PMID: 23681607; PMCID: PMC3721472.
      13. DeKelver RC, Yan M, Ahn EY, Shia WJ, Speck NA, Zhang D. Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential. Blood. 2013 May 2; 121(18):3714-7. PMID: 23426948.
        View in: PubMed
      14. Aryal S, Hu CM, Fang RH, Dehaini D, Carpenter C, Zhang D, Zhang L. Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release. Nanomedicine (Lond). 2013 Aug; 8(8):1271-80. PMID: 23409747.
        View in: PubMed
      15. Ran D, Shia WJ, Lo MC, Fan JB, Knorr DA, Ferrell PI, Ye Z, Yan M, Cheng L, Kaufman DS, Zhang D. RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood. 2013 Apr 11; 121(15):2882-90. PMID: 23372166; PMCID: PMC3624936.
      16. Ahn EE, Higashi T, Yan M, Matsuura S, Hickey CJ, Lo MC, Shia WJ, DeKelver RC, Zhang D. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster. J Biol Chem. 2013 Feb 22; 288(8):5381-8. PMID: 23322776.
        View in: PubMed
      17. Fan JB, Zhang D. ISG15 regulates IFN-? immunity in human mycobacterial disease. Cell Res. 2013 Feb; 23(2):173-5. PMID: 22964713; PMCID: PMC3567825.
      18. Matsuura S, Komeno Y, Stevenson KE, Biggs JR, Lam K, Tang T, Lo MC, Cong X, Yan M, Neuberg DS, Zhang D. Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome. Blood. 2012 Nov 08; 120(19):4028-37. PMID: 22919028; PMCID: PMC3496957.
      19. Lo MC, Peterson LF, Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn EY, Komeno Y, Ly M, Ommen HB, Chen IM, Hokland P, Willman CL, Ren B, Zhang D. Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood. 2012 Aug 16; 120(7):1473-84. PMID: 22740448; PMCID: PMC3423785.
      20. Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR, Zhang D. PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Blood. 2012 May 24; 119(21):4953-62. PMID: 22498736; PMCID: PMC3367897.
      21. Cong XL, Lo MC, Reuter BA, Yan M, Fan JB, Zhang D. Usp18 promotes conventional CD11b+ dendritic cell development. J Immunol. 2012 May 15; 188(10):4776-81. PMID: 22491252; PMCID: PMC3345079.
      22. Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang D. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. PMID: 22223820; PMCID: PMC3321875.
      23. Lam K, Zhang D. RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed). 2012 Jan 01; 17:1120-39. PMID: 22201794; PMCID: PMC3433167.
      24. Burkart C, Fan JB, Zhang D. Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus. J Biol Chem. 2012 Feb 10; 287(7):4883-93. PMID: 22170061; PMCID: PMC3281662.
      25. Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang D. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell. 2011 Apr 22; 42(2):185-98. PMID: 21504830; PMCID: PMC3137374.
      26. Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang D, Li L, Feng GS. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood. 2011 May 19; 117(20):5350-61. PMID: 21450902; PMCID: PMC3109710.
      27. Cong X, Yan M, Yin X, Zhang D. Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation. Blood Cells Mol Dis. 2010 Aug 15; 45(2):103-11. PMID: 20591702.
        View in: PubMed
      28. Yan M, Ahn EY, Hiebert SW, Zhang D. RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis. Blood. 2009 Jan 22; 113(4):883-6. PMID: 19036704.
        View in: PubMed
      29. Ahn EY, Yan M, Malakhova OA, Lo MC, Boyapati A, Ommen HB, Hines R, Hokland P, Zhang D. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):17103-8. PMID: 18952841.
        View in: PubMed