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Deepa Hammaker

TitleProject Scientist
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0656
La Jolla CA 92093
Phone858-246-2395
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS. Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Nat Commun. 2018 May 15; 9(1):1921. PMID: 29765031.
      View in: PubMed
    2. Hammaker D, Firestein GS. Epigenetics of inflammatory arthritis. Curr Opin Rheumatol. 2018 Mar; 30(2):188-196. PMID: 29194108.
      View in: PubMed
    3. Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS. Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochem Pharmacol. 2018 May; 151:282-290. PMID: 29408488.
      View in: PubMed
    4. Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017 10 01; 199(7):2316-2322. PMID: 28807995.
      View in: PubMed
    5. Hammaker D, Whitaker JW, Maeshima K, Boyle DL, Ekwall AH, Wang W, Firestein GS. LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis. Arthritis Rheumatol. 2016 11; 68(11):2637-2645. PMID: 27159840.
      View in: PubMed
    6. Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W. Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nat Commun. 2016 Jun 10; 7:11849. PMID: 27282753; PMCID: PMC4906396.
    7. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
      View in: PubMed
    8. Ekwall AK, Whitaker JW, Hammaker D, Bugbee WD, Wang W, Firestein GS. The Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2015 May; 67(5):1193-202. PMID: 25707478; PMCID: PMC4490933.
    9. Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor. J Pharmacol Exp Ther. 2015 Jun; 353(3):505-16. PMID: 25784649; PMCID: PMC4429673.
    10. Hammaker D, Boyle DL, Topolewski K, Firestein GS. Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. J Inflamm (Lond). 2014; 11:14. PMID: 24855454; PMCID: PMC4030013.
    11. Bartok B, Hammaker D, Firestein GS. Phosphoinositide 3-kinase d regulates migration and invasion of synoviocytes in rheumatoid arthritis. J Immunol. 2014 Mar 01; 192(5):2063-70. PMID: 24470496.
      View in: PubMed
    12. Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS. Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS One. 2014; 9(1):e84818. PMID: 24400116; PMCID: PMC3882259.
    13. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549; PMCID: PMC3397277.
    14. Hammaker D, Topolewski K, Edgar M, Yoshizawa T, Fukushima A, Boyle DL, Burak EC, Sah RL, Firestein GS. Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice. Arthritis Rheum. 2012 Mar; 64(3):678-87. PMID: 21953132; PMCID: PMC3267851.
    15. Luo Y, Boyle DL, Hammaker D, Edgar M, Franzoso G, Firestein GS. Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45ß-deficient mice. Arthritis Rheum. 2011 Oct; 63(10):2949-55. PMID: 21702006; PMCID: PMC3183142.
    16. Hammaker D, Boyle DL, Firestein GS. Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis. Rheumatology (Oxford). 2012 Apr; 51(4):610-8. PMID: 21613249; PMCID: PMC3306173.
    17. Hammaker D, Firestein GS. "Go upstream, young man": lessons learned from the p38 saga. Ann Rheum Dis. 2010 Jan; 69 Suppl 1:i77-82. PMID: 19995751; PMCID: PMC2911016.
    18. Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle DL, Firestein GS. Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. Arthritis Rheum. 2009 Nov; 60(11):3229-40. PMID: 19877043; PMCID: PMC2858378.
    19. Yoshizawa T, Hammaker D, Boyle DL, Corr M, Flavell R, Davis R, Schett G, Firestein GS. Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression. J Immunol. 2009 Jul 15; 183(2):1360-7. PMID: 19561096; PMCID: PMC2744479.
    20. Yoshizawa T, Hammaker D, Sweeney SE, Boyle DL, Firestein GS. Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. J Immunol. 2008 Sep 01; 181(5):3252-8. PMID: 18713996; PMCID: PMC2725405.
    21. Hammaker D, Boyle DL, Inoue T, Firestein GS. Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2007; 9(3):R57. PMID: 17559674; PMCID: PMC2206340.
    22. Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338. PMID: 16953659; PMCID: PMC1560929.
    23. Inoue T, Hammaker D, Boyle DL, Firestein GS. Regulation of JNK by MKK-7 in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Jul; 54(7):2127-35. PMID: 16802349.
      View in: PubMed
    24. Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5484-9. PMID: 16567640; PMCID: PMC1459381.
    25. You X, Boyle DL, Hammaker D, Firestein GS. PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53. Arthritis Res Ther. 2006; 8(6):R157. PMID: 17014719; PMCID: PMC1794498.
    26. Sweeney SE, Hammaker D, Boyle DL, Firestein GS. Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes. J Immunol. 2005 May 15; 174(10):6424-30. PMID: 15879144.
      View in: PubMed
    27. Inoue T, Hammaker D, Boyle DL, Firestein GS. Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. J Immunol. 2005 Apr 01; 174(7):4301-6. PMID: 15778394.
      View in: PubMed
    28. Hammaker D, Boyle DL, Chabaud-Riou M, Firestein GS. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol. 2004 Feb 01; 172(3):1612-8. PMID: 14734742.
      View in: PubMed
    29. Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS. Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. Arthritis Rheum. 2003 Sep; 48(9):2450-60. PMID: 13130464.
      View in: PubMed