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Deborah Witherden

Title(s)Staff Res Assoc , Division of Biological Science
SchoolAcademic Aff
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nguyen QP, Deng TZ, Witherden DA, Goldrath AW. Origins of CD4+ circulating and tissue-resident memory T-cells. Immunology. 2019 May; 157(1):3-12. PMID: 30897205.
      View in: PubMed
    2. Witherden DA, Johnson MD, Havran WL. Coreceptors and Their Ligands in Epithelial ?d T Cell Biology. Front Immunol. 2018; 9:731. PMID: 29686687.
      View in: PubMed
    3. Lee P, Gund R, Dutta A, Pincha N, Rana I, Ghosh S, Witherden D, Kandyba E, MacLeod A, Kobielak K, Havran WL, Jamora C. Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of ?dT-cells. Elife. 2017 12 04; 6. PMID: 29199946.
      View in: PubMed
    4. Nielsen MM, Witherden DA, Havran WL. ?d T cells in homeostasis and host defence of epithelial barrier tissues. Nat Rev Immunol. 2017 Dec; 17(12):733-745. PMID: 28920588.
      View in: PubMed
    5. Ramirez K, Witherden DA, Havran WL. All hands on DE(T)C: Epithelial-resident ?d T cells respond to tissue injury. Cell Immunol. 2015 Jul; 296(1):57-61. PMID: 25958272; PMCID: PMC4466205.
    6. Nielsen MM, Dyring-Andersen B, Schmidt JD, Witherden D, Lovato P, Woetmann A, Ødum N, Poulsen SS, Havran WL, Geisler C, Bonefeld CM. NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity. J Invest Dermatol. 2015 May; 135(5):1311-1319. PMID: 25634359; PMCID: PMC4402141.
    7. Witherden DA, Ramirez K, Havran WL. Multiple Receptor-Ligand Interactions Direct Tissue-Resident ?d T Cell Activation. Front Immunol. 2014; 5:602. PMID: 25505467; PMCID: PMC4241470.
    8. Nielsen MM, Lovato P, MacLeod AS, Witherden DA, Skov L, Dyring-Andersen B, Dabelsteen S, Woetmann A, Ødum N, Havran WL, Geisler C, Bonefeld CM. IL-1ß-dependent activation of dendritic epidermal T cells in contact hypersensitivity. J Immunol. 2014 Apr 01; 192(7):2975-83. PMID: 24600030; PMCID: PMC4020443.
    9. MacLeod AS, Hemmers S, Garijo O, Chabod M, Mowen K, Witherden DA, Havran WL. Dendritic epidermal T cells regulate skin antimicrobial barrier function. J Clin Invest. 2013 Oct; 123(10):4364-74. PMID: 24051381; PMCID: PMC3784546.
    10. Meehan TF, Witherden DA, Kim CH, Sendaydiego K, Ye I, Garijo O, Komori HK, Kumanogoh A, Kikutani H, Eckmann L, Havran WL. Protection against colitis by CD100-dependent modulation of intraepithelial ?d T lymphocyte function. Mucosal Immunol. 2014 Jan; 7(1):134-42. PMID: 23695512.
      View in: PubMed
    11. Witherden DA, Havran WL. Cross-talk between intraepithelial ?d T cells and epithelial cells. J Leukoc Biol. 2013 Jul; 94(1):69-76. PMID: 23620015; PMCID: PMC3685022.
    12. Witherden DA, Havran WL. EPCR: a stress trigger for ?d T cells. Nat Immunol. 2012 Sep; 13(9):812-4. PMID: 22910386.
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    13. Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H, Teyton L, Fischer WH, Havran WL. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal ?d T cell function. Immunity. 2012 Aug 24; 37(2):314-25. PMID: 22902232.
      View in: PubMed
    14. Komori HK, Witherden DA, Kelly R, Sendaydiego K, Jameson JM, Teyton L, Havran WL. Cutting edge: dendritic epidermal ?d T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding. J Immunol. 2012 Apr 01; 188(7):2972-6. PMID: 22393149; PMCID: PMC3311739.
    15. Verdino P, Witherden DA, Podshivalova K, Rieder SE, Havran WL, Wilson IA. cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for ?d T cells. PLoS One. 2011; 6(5):e19828. PMID: 21629689.
      View in: PubMed
    16. Witherden DA, Havran WL. Molecular aspects of epithelial ?d T cell regulation. Trends Immunol. 2011 Jun; 32(6):265-71. PMID: 21481636; PMCID: PMC3109268.
    17. Verdino P, Witherden DA, Ferguson MS, Corper AL, Schiefner A, Havran WL, Wilson IA. Molecular insights into ?d T cell costimulation by an anti-JAML antibody. Structure. 2011 Jan 12; 19(1):80-9. PMID: 21220118.
      View in: PubMed
    18. Witherden DA, Havran WL. Costimulating epithelial ?d T cells. Cell Cycle. 2011 Jan 01; 10(1):4-5. PMID: 21191174.
      View in: PubMed
    19. Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L, Fischer WH, Wilson IA, Havran WL. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science. 2010 Sep 03; 329(5996):1205-10. PMID: 20813954; PMCID: PMC2943937.
    20. Verdino P, Witherden DA, Havran WL, Wilson IA. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science. 2010 Sep 03; 329(5996):1210-4. PMID: 20813955; PMCID: PMC2951132.
    21. Kim CH, Witherden DA, Havran WL. Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes. J Leukoc Biol. 2008 Nov; 84(5):1259-63. PMID: 18667688; PMCID: PMC2567898.
    22. Havran WL, Jameson JM, Witherden DA. Epithelial cells and their neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G627-30. PMID: 16160077.
      View in: PubMed
    23. Jameson JM, Cauvi G, Sharp LL, Witherden DA, Havran WL. Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation. J Exp Med. 2005 Apr 18; 201(8):1269-79. PMID: 15837812; PMCID: PMC2213158.
    24. Baccala R, Witherden D, Gonzalez-Quintial R, Dummer W, Surh CD, Havran WL, Theofilopoulos AN. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol. 2005 Apr 15; 174(8):4606-12. PMID: 15814683.
      View in: PubMed
    25. Sharp LL, Jameson JM, Witherden DA, Komori HK, Havran WL. Dendritic epidermal T-cell activation. Crit Rev Immunol. 2005; 25(1):1-18. PMID: 15833080.
      View in: PubMed
    26. Jameson JM, Sharp LL, Witherden DA, Havran WL. Regulation of skin cell homeostasis by gamma delta T cells. Front Biosci. 2004 Sep 01; 9:2640-51. PMID: 15358587.
      View in: PubMed
    27. Jameson JM, Cauvi G, Witherden DA, Havran WL. A keratinocyte-responsive gamma delta TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis. J Immunol. 2004 Mar 15; 172(6):3573-9. PMID: 15004158.
      View in: PubMed
    28. Jameson J, Witherden D, Havran WL. T-cell effector mechanisms: gammadelta and CD1d-restricted subsets. Curr Opin Immunol. 2003 Jun; 15(3):349-53. PMID: 12787763.
      View in: PubMed
    29. Witherden DA, Boismenu R, Havran WL. CD81 and CD28 costimulate T cells through distinct pathways. J Immunol. 2000 Aug 15; 165(4):1902-9. PMID: 10925271.
      View in: PubMed
    30. Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D. Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. J Exp Med. 2000 Jan 17; 191(2):355-64. PMID: 10637279.
      View in: PubMed
    31. Witherden DA, Rieder SE, Boismenu R, Havran WL. A role for epithelial gamma delta T cells in tissue repair. Springer Semin Immunopathol. 2000; 22(3):265-81. PMID: 11116957.
      View in: PubMed
    32. Witherden DA, Kimpton WG, Abernethy NJ, Cahill RN. Changes in thymic export of gamma delta and alpha beta T cells during fetal and postnatal development. Eur J Immunol. 1994 Oct; 24(10):2329-36. PMID: 7925561.
      View in: PubMed
    33. Witherden DA, Abernethy NJ, Kimpton WG, Cahill RN. Changes in thymic export of L-selectin+ gamma delta and alpha beta T cells during fetal and postnatal development. Eur J Immunol. 1994 May; 24(5):1234-9. PMID: 7514135.
      View in: PubMed
    34. Witherden DA, Abernethy NJ, Kimpton WG, Cahill RN. CD45RA expression of gamma delta and alpha beta T cells emigrating from the fetal and postnatal thymus. Eur J Immunol. 1994 Jan; 24(1):186-90. PMID: 8020555.
      View in: PubMed