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David Natale

Title(s)Assistant Professor, Reproductive Medicine
SchoolHealth Sciences
Phone858-822-0758
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    Stress-mediated trophoblast proliferation: adaptation or pathology?
    NIH/NICHD R01HD100179Jul 20, 2019 - May 31, 2024
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wattez JS, Qiao L, Lee S, Natale DRC, Shao J. The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. Dev Dyn. 2019 May; 248(5):363-374. PMID: 30843624.
      View in: PubMed
    2. Albers RE, Kaufman MR, Natale BV, Keoni C, Kulkarni-Datar K, Min S, Williams CR, Natale DRC, Brown TL. Trophoblast-Specific Expression of Hif-1a Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction. Sci Rep. 2019 Feb 26; 9(1):2742. PMID: 30808910.
      View in: PubMed
    3. Llurba Olive E, Xiao E, Natale DR, Fisher SA. Oxygen and lack of oxygen in fetal and placental development, feto-placental coupling, and congenital heart defects. Birth Defects Res. 2018 12 01; 110(20):1517-1530. PMID: 30576091.
      View in: PubMed
    4. Natale BV, Mehta P, Vu P, Schweitzer C, Gustin K, Kotadia R, Natale DRC. Reduced Uteroplacental Perfusion Pressure (RUPP) causes altered trophoblast differentiation and pericyte reduction in the mouse placenta labyrinth. Sci Rep. 2018 Nov 21; 8(1):17162. PMID: 30464252.
      View in: PubMed
    5. Albers RE, Selesniemi K, Natale DRC, Brown TL. TGF-ß induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation. Int J Stem Cells. 2018 May 30; 11(1):111-120. PMID: 29699384.
      View in: PubMed
    6. Langford MB, Outhwaite JE, Hughes M, Natale DRC, Simmons DG. Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Sci Rep. 2018 Mar 02; 8(1):3961. PMID: 29500366.
      View in: PubMed
    7. Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul Nambi Rajan K, Nelson KK, Chang CW, Moretto-Zita M, Natale DR, Laurent LC, Parast MM. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018 01 29; 145(2). PMID: 29361559.
      View in: PubMed
    8. Albers RE, Waker CA, Keoni C, Kaufman MR, Bottomley MA, Min S, Natale DR, Brown TL. Gestational differences in murine placenta: Glycolytic metabolism and pregnancy parameters. Theriogenology. 2018 Feb; 107:115-126. PMID: 29145065.
      View in: PubMed
    9. Kreisman MJ, Song CI, Yip K, Natale BV, Natale DR, Breen KM. Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse. Endocrinology. 2017 09 01; 158(9):2884-2894. PMID: 28911172.
      View in: PubMed
    10. Natale BV, Schweitzer C, Hughes M, Globisch MA, Kotadia R, Tremblay E, Vu P, Cross JC, Natale DRC. Sca-1 identifies a trophoblast population with multipotent potential in the mid-gestation mouse placenta. Sci Rep. 2017 07 17; 7(1):5575. PMID: 28717241.
      View in: PubMed
    11. Min S, Natale BV, Natale DRC. Temporal and spatial expression of glyceraldehyde 3-phosphate dehydrogenase (Gapdh) in the mouse placenta. Placenta. 2017 Sep; 57:170-174. PMID: 28864008.
      View in: PubMed
    12. Kenchegowda D, Natale B, Lemus MA, Natale DR, Fisher SA. Inactivation of maternal Hif-1a at mid-pregnancy causes placental defects and deficits in oxygen delivery to the fetal organs under hypoxic stress. Dev Biol. 2017 02 15; 422(2):171-185. PMID: 27940158.
      View in: PubMed
    13. Abumaree MH, Almutairi A, Cash S, Boeuf P, Chamley LW, Gamage T, James JL, Kalionis B, Khong TY, Kolahi KS, Lim R, Liong S, Morgan TK, Motomura K, Peiris HN, Pelekanos RA, Pelzer E, Shafiee A, Lash GE, Natale D. IFPA meeting 2015 workshop report IV: placenta and obesity; stem cells of the feto-maternal interface; placental immunobiology and infection. Placenta. 2016 12; 48 Suppl 1:S17-S20. PMID: 27506263.
      View in: PubMed
    14. Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C. ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Arthritis Rheumatol. 2016 Mar; 68(3):730-739. PMID: 26474194.
      View in: PubMed
    15. Moretto Zita M, Soncin F, Natale D, Pizzo D, Parast M. Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem. 2015 Dec 11; 290(50):30152-62. PMID: 26491013.
      View in: PubMed
    16. Outhwaite JE, Natale BV, Natale DR, Simmons DG. Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta. Placenta. 2015 Mar; 36(3):304-11. PMID: 25577283.
      View in: PubMed
    17. Soncin F, Natale D, Parast MM. Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci. 2015 Apr; 72(7):1291-302. PMID: 25430479.
      View in: PubMed
    18. Carey EA, Albers RE, Doliboa SR, Hughes M, Wyatt CN, Natale DR, Brown TL. AMPK knockdown in placental trophoblast cells results in altered morphology and function. Stem Cells Dev. 2014 Dec 01; 23(23):2921-30. PMID: 25003940.
      View in: PubMed
    19. Kaufman MR, Albers RE, Keoni C, Kulkarni-Datar K, Natale DR, Brown TL. Important aspects of placental-specific gene transfer. Theriogenology. 2014 Oct 15; 82(7):1043-8. PMID: 25110063.
      View in: PubMed
    20. Toselli C, Hyslop CM, Hughes M, Natale DR, Santamaria P, Huang CT. Contribution of a non-ß-cell source to ß-cell mass during pregnancy. PLoS One. 2014; 9(6):e100398. PMID: 24940737.
      View in: PubMed
    21. Hughes M, Natale BV, Simmons DG, Natale DR. Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta. Placenta. 2013 Sep; 34(9):831-5. PMID: 23830620.
      View in: PubMed
    22. Watson ED, Hughes M, Simmons DG, Natale DR, Sutherland AE, Cross JC. Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development. Dev Dyn. 2011 Nov; 240(11):2505-19. PMID: 21972064.
      View in: PubMed
    23. Gasperowicz M, Natale DR. Establishing three blastocyst lineages--then what? Biol Reprod. 2011 Apr; 84(4):621-30. PMID: 21123814.
      View in: PubMed
    24. Lash GE, Burton GJ, Chamley LW, Clifton VL, Constancia M, Crocker IP, Dantzer V, Desoye G, Drewlo S, Hemmings DG, Hiendleder S, Kalionis B, Keelan JA, Kudo Y, Lewis RM, Manuelpillai U, Murthi P, Natale D, Pfarrer C, Robertson S, Saffery R, Saito S, Sferruzzi-Perri A, Sobrevia L, Waddell BJ, Roberts CT. IFPA Meeting 2009 workshops report. Placenta. 2010 Mar; 31 Suppl:S4-20. PMID: 20064659.
      View in: PubMed
    25. Natale DR, Hemberger M, Hughes M, Cross JC. Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate. Dev Biol. 2009 Nov 01; 335(1):120-31. PMID: 19716815.
      View in: PubMed
    26. Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC. Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development. 2008 Jun; 135(12):2083-91. PMID: 18448564.
      View in: PubMed
    27. Hemberger M, Yang W, Natale D, Brown TL, Dunk C, Gargett CE, Tanaka S. Stem cells from fetal membranes - a workshop report. Placenta. 2008 Mar; 29 Suppl A:S17-9. PMID: 18155293.
      View in: PubMed
    28. Cross JC, Nakano H, Natale DR, Simmons DG, Watson ED. Branching morphogenesis during development of placental villi. Differentiation. 2006 Sep; 74(7):393-401. PMID: 16916377.
      View in: PubMed
    29. Natale DR, Starovic M, Cross JC. Phenotypic analysis of the mouse placenta. Methods Mol Med. 2006; 121:275-93. PMID: 16251749.
      View in: PubMed
    30. Paliga AJ, Natale DR, Watson AJ. p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development. Biol Cell. 2005 Aug; 97(8):629-40. PMID: 15850458.
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    31. Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 2004 Nov; 7(5):763-9. PMID: 15525537.
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    32. Watson AJ, Natale DR, Barcroft LC. Molecular regulation of blastocyst formation. Anim Reprod Sci. 2004 Jul; 82-83:583-92. PMID: 15271481.
      View in: PubMed
    33. Natale DR, Paliga AJ, Beier F, D'Souza SJ, Watson AJ. p38 MAPK signaling during murine preimplantation development. Dev Biol. 2004 Apr 01; 268(1):76-88. PMID: 15031106.
      View in: PubMed
    34. Natale DR, Watson AJ. Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Mech Dev. 2002 Dec; 119 Suppl 1:S21-6. PMID: 14516655.
      View in: PubMed
    35. Natale DR, Watson AJ. Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Gene Expr Patterns. 2002 Nov; 2(1-2):17-22. PMID: 12617831.
      View in: PubMed
    36. Natale DR, De Sousa PA, Westhusin ME, Watson AJ. Sensitivity of bovine blastocyst gene expression patterns to culture environments assessed by differential display RT-PCR. Reproduction. 2001 Nov; 122(5):687-93. PMID: 11690528.
      View in: PubMed
    37. Natale DR, Kidder GM, Westhusin ME, Watson AJ. Assessment by differential display-RT-PCR of mRNA transcript transitions and alpha-amanitin sensitivity during bovine preattachment development. Mol Reprod Dev. 2000 Feb; 55(2):152-63. PMID: 10618654.
      View in: PubMed
    38. Watson AJ, De Sousa P, Caveney A, Barcroft LC, Natale D, Urquhart J, Westhusin ME. Impact of bovine oocyte maturation media on oocyte transcript levels, blastocyst development, cell number, and apoptosis. Biol Reprod. 2000 Feb; 62(2):355-64. PMID: 10642573.
      View in: PubMed