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David Malinak

Title(s)Resident Physician, Medicine
SchoolHealth Sciences
Address200 W. Arbor Drive #8425
San Diego CA 92103
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators. J Enzyme Inhib Med Chem. 2020 Dec; 35(1):478-488. Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K. PMID: 31910701.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Wide-Antimicrobial Spectrum of Picolinium Salts. Molecules. 2020 May 11; 25(9). Salajkova S, Benkova M, Marek J, Sleha R, Prchal L, Malinak D, Dolezal R, Sepcic K, Gunde-Cimerman N, Kuca K, Soukup O. PMID: 32403238.
      View in: PubMed   Mentions:    Fields:    
    3. Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity. J Biophotonics. 2019 12; 12(12):e201900024. Salajkova S, Sramek M, Malinak D, Havel F, Musilek K, Benkova M, Soukup O, Vasicova P, Prchal L, Dolezal R, Hodny Z, Bartek J, Zarska M, Kuca K. PMID: 31298802.
      View in: PubMed   Mentions:    Fields:    
    4. Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes. Chem Biol Interact. 2019 Jul 01; 307:16-20. Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z. PMID: 31004594.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Donepezil Derivatives Targeting Amyloid-ß Cascade in Alzheimer's Disease. Curr Alzheimer Res. 2019; 16(9):772-800. Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J. PMID: 30819078.
      View in: PubMed   Mentions:    Fields:    
    6. Oxime K203: a drug candidate for the treatment of tabun intoxication. Arch Toxicol. 2019 03; 93(3):673-691. Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J. PMID: 30564897.
      View in: PubMed   Mentions: 1     Fields:    
    7. Profiling donepezil template into multipotent hybrids with antioxidant properties. J Enzyme Inhib Med Chem. 2018 Dec; 33(1):583-606. Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D, Kuca K, Korabecny J. PMID: 29529892.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. J Med Chem. 2018 12 13; 61(23):10753-10766. Zorbaz T, Malinak D, Marakovic N, Macek Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinic M, Kuca K, Kovarik Z, Musilek K. PMID: 30383374.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study. Molecules. 2018 Sep 07; 23(9). Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K. PMID: 30205495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro. Eur J Med Chem. 2018 Feb 25; 146:38-46. Honegr J, Malinak D, Dolezal R, Soukup O, Benkova M, Hroch L, Benek O, Janockova J, Kuca K, Prymula R. PMID: 29407964.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery. Molecules. 2018 Jan 04; 23(1). Honegr J, Dolezal R, Malinak D, Benkova M, Soukup O, Almeida JSFD, Franca TCC, Kuca K, Prymula R. PMID: 29300367.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? Med Chem. 2018; 14(3):281-292. Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K. PMID: 29332594.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Addressing Food Insecurity in Family Medicine and Medical Education. Fam Med. 2017 Nov; 49(10):765-771. Smith S, Malinak D, Chang J, Schultz A, Brownell K. PMID: 29190401.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). Expert Opin Ther Pat. 2017 Sep; 27(9):971-985. Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K. PMID: 28569609.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    15. Implementation of a food insecurity screening and referral program in student-run free clinics in San Diego, California. Prev Med Rep. 2017 Mar; 5:134-139. Smith S, Malinak D, Chang J, Perez M, Perez S, Settlecowski E, Rodriggs T, Hsu M, Abrew A, Aedo S. PMID: 27990340.
      View in: PubMed   Mentions:
    16. SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. Arch Toxicol. 2016 Dec; 90(12):2831-2859. Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K. PMID: 27582056.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. Eur J Med Chem. 2016 Oct 04; 121:699-711. Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J, Honegr J, Ramalho TC, Kuca K. PMID: 27341309.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety. Bioorg Med Chem. 2016 Feb 15; 24(4):841-8. Soukup O, Dolezal R, Malinak D, Marek J, Salajkova S, Pasdiorova M, Honegr J, Korabecny J, Nachtigal P, Nachon F, Jun D, Kuca K. PMID: 26774252.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment. Molecules. 2015 Dec 10; 20(12):22084-101. Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L, Sepsova V, Hrabinova M, Soukup O, Jun D, Kuca K. PMID: 26690394.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. J Med Chem. 2015 Nov 25; 58(22):8985-9003. Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K. PMID: 26503905.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. Synthesis and disinfection effect of the pyridine-4-aldoxime based salts. Molecules. 2015 Feb 24; 20(3):3681-96. Marek J, Malinak D, Dolezal R, Soukup O, Pasdiorova M, Dolezal M, Kuca K. PMID: 25719739.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists. Curr Med Chem. 2015; 22(29):3306-25. Honegr J, Soukup O, Doležal R, Malinak D, Penhaker M, Prymula R, Kuca K. PMID: 26295466.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase. J Mol Graph Model. 2015 Mar; 56:113-29. Dolezal R, Korabecny J, Malinak D, Honegr J, Musilek K, Kuca K. PMID: 25588616.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: synthesis and antimicrobial activity. Bioorg Med Chem Lett. 2014 Nov 15; 24(22):5238-41. Malinak D, Dolezal R, Marek J, Salajkova S, Soukup O, Vejsova M, Korabecny J, Honegr J, Penhaker M, Musilek K, Kuca K. PMID: 25442318.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells