Daniel Chao

Title(s)Assistant Professor Of Clinical, Ophthalmology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoVitreoretinal Surgery Fellowship2016
    Bascom Palmer Eye Institute/ University of MiamiOphthalmology Residency2014
    Santa Clara Valley Medical CenterTransitional Year2011
    Stanford UniversityPhD, Neurosciences2009Medicine
    Stanford UniversityMD2010Medicine
    Virginia Commonwealth UniversityB.S. Biomedical Engineering2001Engineering

    Collapse Overview 
    Collapse Overview
    Dr. Chao is an Assistant Professor of Ophthalmology at the Shiley Eye Institute at UCSD. He is a vitreoretinal surgeon and clinician-scientist, focused on translational research in retinal diseases. In addition to seeing patients with conditions such as retinal detachment, macular degeneration, and diabetic retinopathy, he runs a broad resaerch program focused on discovering new therapeutics for macular degeneration using zebrafish and mouse models. He also serves as principal investigator on a number of clinical trials investigating investigational medications for retinal disease. He is also Director of Ophthalmology Medical Student Education, where he is involved in coordinating medical student education and mentoring medical students interested in ophthalmology. He is also extremely interested in entrepreneurship and is co-founder of a company developing a new therapeutic for dry AMD, based on IP developed by he and his scientific collaborator at UCSD. He also collaborates and serves on the advisory boards of local San Diego biotech companies to develop new therapeutics and technologies for retinal diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Dissecting the role of ELOVL2 in Drusen Biogenesis and Age Related Macular Degeneration
    NIH/NEI K08EY030510Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator
    Zebrafish as a model for wet macular degeneration
    Brightfocus Foundation Jul 1, 2017 - Jul 1, 2019
    Role: PI
    Role Description: Used vhl zebrafish mutant to perform a small molecule screen to identify inhibitors of retinal neovascularization

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Assessment of respiratory droplet transmission during the ophthalmic slit lamp exam: a particle tracking analysis. Am J Ophthalmol. 2020 Sep 24. Shah SH, Garg AK, Patel S, Yim W, Jokerst J, Chao DL. PMID: 32980331.
      View in: PubMed   Mentions:    Fields:    
    2. Assessing the Physiological Relevance of Cough Simulators for Respiratory Droplet Dispersion. J Clin Med. 2020 Sep 17; 9(9). Patel SH, Yim W, Garg AK, Shah SH, Jokerst JV, Chao DL. PMID: 32957639.
      View in: PubMed   Mentions:
    3. Potential of Ocular Transmission of SARS-CoV-2: A Review. Vision (Basel). 2020 Sep 01; 4(3). Barnett BP, Wahlin K, Krawczyk M, Spencer D, Welsbie D, Afshari N, Chao D. PMID: 32883010.
      View in: PubMed   Mentions:
    4. Targeting of the NRL Pathway as a Therapeutic Strategy to Treat Retinitis Pigmentosa. J Clin Med. 2020 Jul 13; 9(7). Moore SM, Skowronska-Krawczyk D, Chao DL. PMID: 32668775.
      View in: PubMed   Mentions:
    5. ELOVL2: Not just a biomarker of aging. Transl Med Aging. 2020; 4:78-80. Chao DL, Skowronska-Krawczyk D. PMID: 33043173.
      View in: PubMed   Mentions:
    6. Multiexon deletion alleles of ATF6 linked to achromatopsia. JCI Insight. 2020 04 09; 5(7). Lee EJ, Chiang WJ, Kroeger H, Bi CX, Chao DL, Skowronska-Krawczyk D, Mastey RR, Tsang SH, Chea L, Kim K, Lambert SR, Grandjean JM, Baumann B, Audo I, Kohl S, Moore AT, Wiseman RL, Carroll J, Lin JH. PMID: 32271167.
      View in: PubMed   Mentions:    Fields:    
    7. Quality of Life Assessment of Severely Visually Impaired Individuals Using Aira Assistive Technology System. Transl Vis Sci Technol. 2020 Mar; 9(4):21. Park K, Kim Y, Nguyen BJ, Chen A, Chao DL. PMID: 32818108.
      View in: PubMed   Mentions:
    8. Anesthesia for Intravitreal Injection: A Systematic Review. Clin Ophthalmol. 2020; 14:543-550. Han J, Rinella NT, Chao DL. PMID: 32161439.
      View in: PubMed   Mentions:
    9. Genetically Encodable Contrast Agents for Optical Coherence Tomography. ACS Nano. 2020 07 28; 14(7):7823-7831. Lu GJ, Chou LD, Malounda D, Patel AK, Welsbie DS, Chao DL, Ramalingam T, Shapiro MG. PMID: 32023037.
      View in: PubMed   Mentions: 1     Fields:    
    10. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. Aging Cell. 2020 02; 19(2):e13100. Chen D, Chao DL, Rocha L, Kolar M, Nguyen Huu VA, Krawczyk M, Dasyani M, Wang T, Jafari M, Jabari M, Ross KD, Saghatelian A, Hamilton BA, Zhang K, Skowronska-Krawczyk D. PMID: 31943697.
      View in: PubMed   Mentions: 3     Fields:    
    11. Large-scale assessment of needs in low vision individuals using the Aira assistive technology. Clin Ophthalmol. 2019; 13:1853-1868. Nguyen BJ, Chen WS, Chen AJ, Utt A, Hill E, Apgar R, Chao DL. PMID: 31571823.
      View in: PubMed   Mentions:
    12. RESOLUTION, DEPTH OF FIELD, AND PHYSICIAN SATISFACTION DURING DIGITALLY ASSISTED VITREORETINAL SURGERY. Retina. 2019 Sep; 39(9):1768-1771. Freeman WR, Chen KC, Ho J, Chao DL, Ferreyra HA, Tripathi AB, Nudleman E, Bartsch DU. PMID: 29965938.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Genetics of Diabetic Retinopathy. Curr Diab Rep. 2019 07 29; 19(9):67. Han J, Lando L, Skowronska-Krawczyk D, Chao DL. PMID: 31359159.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. COMPARISON OF RETINAL PATHOLOGY VISUALIZATION IN MULTISPECTRAL SCANNING LASER IMAGING. Retina. 2019 Jul; 39(7):1333-1342. Meshi A, Lin T, Dans K, Chen KC, Amador M, Hasenstab K, Muftuoglu IK, Nudleman E, Chao D, Bartsch DU, Freeman WR. PMID: 29554078.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Success in Attaining Independent Funding Among National Institutes of Health K Grant Awardees in Ophthalmology-Reply. JAMA Ophthalmol. 2019 06 01; 137(6):720-721. Chao DL, Protopsaltis NJ. PMID: 30946441.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. OCT Angiography Biomarkers for Predicting Visual Outcomes after Ranibizumab Treatment for Diabetic Macular Edema. Ophthalmol Retina. 2019 10; 3(10):826-834. Hsieh YT, Alam MN, Le D, Hsiao CC, Yang CH, Chao DL, Yao X. PMID: 31227330.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Real-World Trends in Intravitreal Injection Practices among American Retina Specialists. Ophthalmol Retina. 2019 08; 3(8):656-662. Chaturvedi R, Wannamaker KW, Riviere PJ, Khanani AM, Wykoff CC, Chao DL. PMID: 31133544.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Comparison of smartphone ophthalmoscopy vs conventional direct ophthalmoscopy as a teaching tool for medical students: the COSMOS study. Clin Ophthalmol. 2019; 13:391-401. Kim Y, Chao DL. PMID: 30858689.
      View in: PubMed   Mentions:
    19. Analysis of Patient-Reported Barriers to Diabetic Retinopathy Follow-Up. Ophthalmic Surg Lasers Imaging Retina. 2019 02 01; 50(2):99-105. Lu AJ, Chen AJ, Hwang V, Law PY, Stewart JM, Chao DL. PMID: 30768217.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Bilateral Choroidal Melanocytosis. Ophthalmology. 2019 02; 126(2):220. Amador-Patarroyo MJ, Ahmed E, Chao DL. PMID: 30683179.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Artificial intelligence-based decision-making for age-related macular degeneration. Theranostics. 2019; 9(1):232-245. Hwang DK, Hsu CC, Chang KJ, Chao D, Sun CH, Jheng YC, Yarmishyn AA, Wu JC, Tsai CY, Wang ML, Peng CH, Chien KH, Kao CL, Lin TC, Woung LC, Chen SJ, Chiou SH. PMID: 30662564.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. Long-Chain Polyunsaturated Fatty Acids and Age-Related Macular Degeneration. Adv Exp Med Biol. 2019; 1185:39-43. Skowronska-Krawczyk D, Chao DL. PMID: 31884586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Emerging Concepts for RNA Therapeutics for Inherited Retinal Disease. Adv Exp Med Biol. 2019; 1185:85-89. Moore SM, Skowronska-Krawczyk D, Chao DL. PMID: 31884593.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Application of subthreshold laser therapy in retinal diseases: a review. Expert Rev Ophthalmol. 2018; 13(6):311-320. Moore SM, Chao DL. PMID: 31692951.
      View in: PubMed   Mentions:
    25. Success in Attaining Independent Funding Among National Institutes of Health K Grant Awardees in Ophthalmology: An Extended Follow-up. JAMA Ophthalmol. 2018 12 01; 136(12):1335-1340. Protopsaltis NJ, Chen AJ, Hwang V, Gedde SJ, Chao DL. PMID: 30267067.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Improvement in Patient-Reported Quality of Life Outcomes in Severely Visually Impaired Individuals Using the Aira Assistive Technology System. Transl Vis Sci Technol. 2018 Sep; 7(5):30. Nguyen BJ, Kim Y, Park K, Chen AJ, Chen S, Van Fossan D, Chao DL. PMID: 30386682.
      View in: PubMed   Mentions:
    27. Factors Associated with Non-compliance for Diabetic Retinopathy Follow-up in an Urban Safety-Net Hospital. Ophthalmic Epidemiol. 2018 Oct - Dec; 25(5-6):443-450. Chen AJ, Hwang V, Law PY, Stewart JM, Chao DL. PMID: 30081686.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. In vivo photoacoustic imaging of chorioretinal oxygen gradients. J Biomed Opt. 2018 03; 23(3):1-8. Hariri A, Wang J, Kim Y, Jhunjhunwala A, Chao DL, Jokerst JV. PMID: 29524321.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    29. BILATERAL ENTEROCOCCUS FAECALIS ENDOPHTHALMITIS WITH MULTIPLE RECURRENCES. Retin Cases Brief Rep. 2018 Feb 27. Aderman CM, Chao DL, Obeid A, Schwartz DM, Bhisitkul RB, Chiu CS. PMID: 29489562.
      View in: PubMed   Mentions:    Fields:    
    30. Cryptococcal choroiditis in advanced AIDS with clinicopathologic correlation. Am J Ophthalmol Case Rep. 2018 Jun; 10:51-54. Aderman CM, Gorovoy IR, Chao DL, Bloomer MM, Obeid A, Stewart JM. PMID: 29780913.
      View in: PubMed   Mentions:
    31. The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging. Photoacoustics. 2018 Mar; 9:10-20. Hariri A, Lemaster J, Wang J, Jeevarathinam AS, Chao DL, Jokerst JV. PMID: 29234601.
      View in: PubMed   Mentions:
    32. Cell autonomous sonic hedgehog signaling contributes to maintenance of retinal endothelial tight junctions. Exp Eye Res. 2017 11; 164:82-89. Díaz-Coránguez M, Chao DL, Salero EL, Goldberg JL, Antonetti DA. PMID: 28743502.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    33. Myopia is Inversely Associated With the Prevalence of Diabetic Retinopathy in the South Korean Population. Am J Ophthalmol. 2016 Dec; 172:39-44. Chao DL, Lin SC, Chen R, Lin SC. PMID: 27640007.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Prognostic Implications of Tumor Diameter in Association With Gene Expression Profile for Uveal Melanoma. JAMA Ophthalmol. 2016 Jul 01; 134(7):734-40. Walter SD, Chao DL, Feuer W, Schiffman J, Char DH, Harbour JW. PMID: 27123792.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    35. Refractive Error and the Risk of Age-Related Macular Degeneration in the South Korean Population. Asia Pac J Ophthalmol (Phila). 2016 Mar-Apr; 5(2):115-21. Lin SC, Singh K, Chao DL, Lin SC. PMID: 26914445.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Hydroxyapatite versus polyethylene orbital implants for patients undergoing enucleation for uveal melanoma. Can J Ophthalmol. 2015 Apr; 50(2):151-4. Chao DL, Harbour JW. PMID: 25863856.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Hematic cyst around orbital floor implant masquerading as choroidal mass. JAMA Ophthalmol. 2015 Mar; 133(3):e143534. Chao DL, Ko MJ, Johnson TE. PMID: 25763555.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Peripapillary serous detachment in multiple evanescent white dot syndrome. Retina. 2015 Mar; 35(3):521-4. Chao DL, Marsiglia M, Ahmad B, Sridhar J, Shah GK, de Souza EC, Yannuzzi LA, Albini TA. PMID: 25545483.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Penetrating ocular fishhook injury. JAMA Ophthalmol. 2015 Mar; 133(3):347-8. Chao DL, Erickson BP, Rachitskaya AV. PMID: 25763547.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Stability of macular traction in involutional diabetic retinopathy over a 5-year course. Ophthalmic Surg Lasers Imaging Retina. 2015 Jan; 46(1):131-3. Chao DL, Flynn HW. PMID: 25559526.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Acute postoperative visual loss. JAMA Ophthalmol. 2014 Nov; 132(11):1365-6. Churgin DS, Schatz NJ, Chao DL. PMID: 25392965.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Safety of bilateral intravitreal injections delivered in a teaching institution. Expert Opin Drug Deliv. 2014 Jul; 11(7):991-3. Chao DL, Gregori NZ, Khandji J, Goldhardt R. PMID: 24815986.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. A molecular revolution in uveal melanoma: implications for patient care and targeted therapy. Ophthalmology. 2014 Jun; 121(6):1281-8. Harbour JW, Chao DL. PMID: 24480708.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    44. Infectious Pseudomonas scleritis after strabismus surgery. J AAPOS. 2013 Aug; 17(4):423-5. Chao DL, Albini TA, McKeown CA, Cavuoto KM. PMID: 23871294.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Characterization of a clinician-scientist cohort in ophthalmology: a demographic analysis of k grant awardees in ophthalmology. Ophthalmology. 2013 Oct; 120(10):2146-50. Chao DL, Schiffman JC, Gedde SJ. PMID: 23631948.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans. Elife. 2013 Mar 06; 2:e00133. Yan J, Chao DL, Toba S, Koyasako K, Yasunaga T, Hirotsune S, Shen K. PMID: 23482306.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    47. Axial length does not correlate with degree of visual field loss in myopic Chinese individuals with glaucomatous appearing optic nerves. J Glaucoma. 2010 Oct-Nov; 19(8):509-13. Chao DL, Shrivastava A, Kim DH, Lin H, Singh K. PMID: 20179621.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Transient cell-cell interactions in neural circuit formation. Nat Rev Neurosci. 2009 Apr; 10(4):262-71. Chao DL, Ma L, Shen K. PMID: 19300445.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    49. Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C. elegans. Mol Cell Neurosci. 2008 Oct; 39(2):248-57. Chao DL, Shen K. PMID: 18675916.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    50. Single-synapse ablation and long-term imaging in live C. elegans. J Neurosci Methods. 2008 Aug 15; 173(1):20-6. Allen PB, Sgro AE, Chao DL, Doepker BE, Scott Edgar J, Shen K, Chiu DT. PMID: 18579213.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    51. Firing to wire: a role for activity in establishing layer specificity in the cortex. J Neurosci. 2007 Oct 10; 27(41):10922-3. Chao DL, Wang GJ. PMID: 17928433.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    52. Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science. 2007 Aug 17; 317(5840):947-51. Ding M, Chao D, Wang G, Shen K. PMID: 17626846.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    53. Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat. J Neurotrauma. 2003 Apr; 20(4):337-45. Kwon TH, Chao DL, Malloy K, Sun D, Alessandri B, Bullock MR. PMID: 12866813.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
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