Colleen McHugh

TitleAssistant Professor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0314
La Jolla CA 92093
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    1. McHugh CA, Guttman M. RAP-MS: A Method to Identify Proteins that Interact Directly with a Specific RNA Molecule in Cells. Methods Mol Biol. 2018; 1649:473-488. PMID: 29130217.
      View in: PubMed
    2. McHugh CA, Chen CK, Chow A, Surka CF, Tran C, McDonel P, Pandya-Jones A, Blanco M, Burghard C, Moradian A, Sweredoski MJ, Shishkin AA, Su J, Lander ES, Hess S, Plath K, Guttman M. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. Nature. 2015 May 14; 521(7551):232-6. PMID: 25915022; PMCID: PMC4516396.
    3. McHugh CA, Fontana J, Nemecek D, Cheng N, Aksyuk AA, Heymann JB, Winkler DC, Lam AS, Wall JS, Steven AC, Hoiczyk E. A virus capsid-like nanocompartment that stores iron and protects bacteria from oxidative stress. EMBO J. 2014 Sep 01; 33(17):1896-911. PMID: 25024436; PMCID: PMC4195785.
    4. McHugh CA, Russell P, Guttman M. Methods for comprehensive experimental identification of RNA-protein interactions. Genome Biol. 2014 Jan 27; 15(1):203. PMID: 24467948; PMCID: PMC4054858.
    5. Koch MK, McHugh CA, Hoiczyk E. BacM, an N-terminally processed bactofilin of Myxococcus xanthus, is crucial for proper cell shape. Mol Microbiol. 2011 May; 80(4):1031-51. PMID: 21414039; PMCID: PMC3091990.
    6. Hoiczyk E, Ring MW, McHugh CA, Schwär G, Bode E, Krug D, Altmeyer MO, Lu JZ, Bode HB. Lipid body formation plays a central role in cell fate determination during developmental differentiation of Myxococcus xanthus. Mol Microbiol. 2009 Oct; 74(2):497-517. PMID: 19788540; PMCID: PMC2877170.
    7. Carra JH, McHugh CA, Mulligan S, Machiesky LM, Soares AS, Millard CB. Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site. BMC Struct Biol. 2007 Nov 06; 7:72. PMID: 17986339; PMCID: PMC2194779.
    8. McHugh CA, Tammariello RF, Millard CB, Carra JH. Improved stability of a protein vaccine through elimination of a partially unfolded state. Protein Sci. 2004 Oct; 13(10):2736-43. PMID: 15340172; PMCID: PMC2286567.
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