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Claire Bristow

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0507
La Jolla CA 92093
Emailcbristow@ucsd.edu
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    Collapse Overview 
    Collapse Overview
    Claire C. Bristow, PhD, MPH, MSc is an epidemiologist focused on prevention, diagnostics and genomics for sexually transmitted infections (STIs) including HIV. Dr. Bristow received a master’s degree in Global Health and Development from the Institute for Child Health at University College London. She completed her master’s in public health and PhD in epidemiology at University of California Los Angeles.

    From 2009 – 2012, Dr. Bristow was a senior research associate for the U.S. Centers for Disease Control in the Division of Tuberculosis Elimination and the Global AIDS Program in South Africa. More recently, Dr. Bristow’s research focused on dual elimination of HIV and syphilis and she co-founded dualelimination.org. In this work, Dr. Bristow has conducted comprehensive evaluations of dual rapid tests for the simultaneous detection of HIV infection and syphilis. In addition, Dr. Bristow is committed to improving point-of-care diagnostics for other STIs as well as implementing multiplex molecular diagnostic approaches in global settings including Mexico, Haiti, Peru, Botswana and South Africa. Dr. Bristow authored a textbook chapter for the American Society for Microbiology Press Molecular Microbiology: Diagnostic Principles and Practice textbook entitled “Diagnostic Approaches to Genitourinary Tract Infections”.

    A major global health threat is antibiotic resistance–when bacteria mutate so antibiotics no longer work in people who need them to treat infections. The emergence and spread of drug-resistant pathogens has accelerated and the therapeutic arsenal is shrinking. The speed with which these drugs are being lost far outpaces the development of replacement drugs. Dr. Bristow is now working to improve technology to detect antimicrobial resistant Neisseria gonorrhoeae and ways to halt the epidemic of resistance. Over the past 75 years, Neisseria gonorrhoeae infections have become increasingly resistant to antimicrobial therapy: first to sulfa-based antibiotics, then penicillins, tetracyclines, fluoroquinolones and now extended-spectrum cephalosporins. The U.S. Centers for Disease Control and Prevention has identified drug-resistant Neisseria gonorrhoeae as one of the top three urgent threats and it also fits into World Health Organization’s plan for addressing the crisis of antibacterial drug resistance. Gonococcal antimicrobial resistance surveillance remains sporadic, limited or even lacking in many regions worldwide. In 2016, Dr. Bristow was awarded a Fogarty-GloCal Fellowship to conduct research in Tijuana to better understand the spread of antibiotic resistance of Neisseria gonorrhoeae. In addition, she has been awarded research support that will be provided for different research aims that are complementary to that project from the UCSD Center for AIDS Research (CFAR). Dr. Bristow is also a co-investigator in the STAR Sexually Transmitted Infections Clinical Trials Group (CTG) funded by the Division of Microbiology and Infectious Diseases (DMID) at the NIAID within the National Institutes of Health.

    To subscribe to Dr. Bristow’s monthly newsletter on Neisseria gonorrhoeae antimicrobial resistance please click here: http://eepurl.com/cQ4X-f


    Collapse Research 
    Collapse Research Activities and Funding
    Molecular epidemiology of HIV and Neisseria gonorrhoeae in the context of drug resistance
    NIH/NIAID K01AI136725Jan 1, 2018 - Dec 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bristow C, Shannon C, de Cortina SH, Klausner JD. Use of oral fluid with a rapid treponemal test for syphilis evaluation. Sex Transm Dis. 2018 Mar 29. PMID: 29596225.
      View in: PubMed
    2. Adachi K, Xu J, Yeganeh N, Camarca M, Morgado MG, Watts DH, Mofenson LM, Veloso VG, Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Ceriotto M, Machado DM, Bryson YJ, Grinsztejn B, Moye J, Klausner JD, Bristow C, Dickover R, Mirochnick M, Nielsen-Saines K. Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission. PLoS One. 2018; 13(1):e0189851. PMID: 29304083.
      View in: PubMed
    3. Bristow C, Klausner JD. Using Treponemal Assay Signal Strength Cutoff Ratios To Predict Syphilis Infection. J Clin Microbiol. 2018 Jan; 56(1). PMID: 29046409.
      View in: PubMed
    4. Salow KR, Cohen AC, Bristow C, McGrath MR, Klausner JD. Comparing mail-in self-collected specimens sent via United States Postal Service versus clinic-collected specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in extra-genital sites. PLoS One. 2017; 12(12):e0189515. PMID: 29240781.
      View in: PubMed
    5. Bristow C, McGrath MR, Cohen AC, Anderson LJ, Gordon KK, Klausner JD. Comparative Evaluation of 2 Nucleic Acid Amplification Tests for the Detection of Chlamydia trachomatis and Neisseria gonorrhoeae at Extragenital Sites. Sex Transm Dis. 2017 Jul; 44(7):398-400. PMID: 28604481.
      View in: PubMed
    6. Herbst de Cortina S, Bristow C, Humphries R, Vargas SK, Konda KA, Caceres CF, Klausner JD. Laboratory Evaluation of a Smartphone-Based Electronic Reader of Rapid Dual Point-of-Care Tests for Antibodies to Human Immunodeficiency Virus and Treponema pallidum Infections. Sex Transm Dis. 2017 Jul; 44(7):412-416. PMID: 28604483.
      View in: PubMed
    7. Kojima N, Park H, Konda KA, Joseph Davey DL, Bristow C, Brown B, Leon SR, Vargas SK, Calvo GM, Caceres CF, Klausner JD. The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru. BMC Infect Dis. 2017 04 11; 17(1):255. PMID: 28399798.
      View in: PubMed
    8. Cristillo AD, Bristow C, Peeling R, Van Der Pol B, de Cortina SH, Dimov IK, Pai NP, Jin Shin D, Chiu RY, Klapperich C, Madhivanan P, Morris SR, Klausner JD. Point-of-Care Sexually Transmitted Infection Diagnostics: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis. 2017 04; 44(4):211-218. PMID: 28282646.
      View in: PubMed
    9. Kojima N, Krupp K, Ravi K, Gowda S, Jaykrishna P, Leonardson-Placek C, Siddhaiah A, Bristow C, Arun A, Klausner JD, Madhivanan P. Implementing and sustaining a mobile medical clinic for prenatal care and sexually transmitted infection prevention in rural Mysore, India. BMC Infect Dis. 2017 03 06; 17(1):189. PMID: 28264668.
      View in: PubMed
    10. Bristow C, Mathelier P, Ocheretina O, Benoit D, Pape JW, Wynn A, Klausner JD. Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis screening and treatment of pregnant women in Port-au-Prince, Haiti. Int J STD AIDS. 2017 10; 28(11):1130-1134. PMID: 28134005.
      View in: PubMed
    11. Billings JD, Joseph Davey DL, Konda KA, Bristow C, Chow J, Klausner JD, Cáceres CF. Factors associated with previously undiagnosed human immunodeficiency virus infection in a population of men who have sex with men and male-to-female transgender women in Lima, Peru. Medicine (Baltimore). 2016 Oct; 95(42):e5147. PMID: 27759645.
      View in: PubMed
    12. Adachi K, Klausner JD, Xu J, Ank B, Bristow C, Morgado MG, Watts DH, Weir F, Persing D, Mofenson LM, Veloso VG, Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Ceriotto M, Machado DM, Bryson YJ, Grinsztejn B, Bastos FI, Siberry G, Nielsen-Saines K. Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected Pregnant Women and Adverse Infant Outcomes. Pediatr Infect Dis J. 2016 Aug; 35(8):894-900. PMID: 27164464; PMCID: PMC4945428 [Available on 08/01/17].
    13. Bristow C, Lee SJ, Severe L, William Pape J, Javanbakht M, Scott Comulada W, Klausner JD. Attributes of diagnostic tests to increase uptake of dual testing for syphilis and HIV in Port-au-Prince, Haiti. Int J STD AIDS. 2017 03; 28(3):259-264. PMID: 27037111.
      View in: PubMed
    14. Allan-Blitz LT, Leon SR, Bristow C, Konda KA, Vargas SK, Flores JA, Brown BJ, Caceres CF, Klausner JD. High prevalence of extra-genital chlamydial or gonococcal infections among men who have sex with men and transgender women in Lima, Peru. Int J STD AIDS. 2017 02; 28(2):138-144. PMID: 26846151.
      View in: PubMed
    15. Bristow C, Severe L, Pape JW, Javanbakht M, Lee SJ, Comulada WS, Klausner JD. Dual rapid lateral flow immunoassay fingerstick wholeblood testing for syphilis and HIV infections is acceptable and accurate, Port-au-Prince, Haiti. BMC Infect Dis. 2016 06 18; 16:302. PMID: 27316352; PMCID: PMC4912739.
    16. Herbst de Cortina S, Bristow C, Joseph Davey D, Klausner JD. A Systematic Review of Point of Care Testing for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis. Infect Dis Obstet Gynecol. 2016; 2016:4386127. PMID: 27313440; PMCID: PMC4899593.
    17. Herbst de Cortina S, Bristow C, Vargas SK, Perez DG, Konda KA, Caceres CF, Klausner JD. Laboratory Evaluation of a Point-of-Care Downward-Flow Assay for Simultaneous Detection of Antibodies to Treponema pallidum and Human Immunodeficiency Virus. J Clin Microbiol. 2016 07; 54(7):1922-1924. PMID: 27147725.
      View in: PubMed
    18. Bristow C, Dong H, Klausner JD. Technological Solutions to Address Drug-Resistant Neisseria gonorrhoeae. Emerg Infect Dis. 2016 May; 22(5):939-40. PMID: 27088665; PMCID: PMC4861538.
    19. Podewils LJ, Bronner Murrison L, Bristow C, Bantubani N, Mametja LD. The other side of surveillance: Monitoring, application, and integration of tuberculosis data to guide and evaluate programme activities in South Africa. S Afr Med J. 2016 Mar 10; 106(4):55. PMID: 27032857; PMCID: PMC4943662.
    20. Bristow C, Larson E, Anderson LJ, Klausner JD. Cost-effectiveness of HIV and syphilis antenatal screening: a modelling study. Sex Transm Infect. 2016 08; 92(5):340-6. PMID: 26920867.
      View in: PubMed
    21. Bristow C, Leon SR, Huang E, Ramos LB, Vargas SK, Flores JA, Konda KA, Caceres CF, Klausner JD. Field Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection in Peru. Sex Transm Dis. 2016 Jan; 43(1):57-60. PMID: 26650998; PMCID: PMC4675040 [Available on 01/01/17].
    22. Bristow C, Leon SR, Huang E, Brown BJ, Ramos LB, Vargas SK, Flores JA, Caceres CF, Klausner JD. Field evaluation of a dual rapid diagnostic test for HIV infection and syphilis in Lima, Peru. Sex Transm Infect. 2016 May; 92(3):182-5. PMID: 26670914; PMCID: PMC4875763 [Available on 05/01/17].
    23. Bristow C, Klausner JD. Cuba: defeating mother-to-child transmission of syphilis. Lancet. 2015 Oct 17; 386(10003):1533. PMID: 26530617.
      View in: PubMed
    24. Adachi K, Klausner JD, Bristow C, Xu J, Ank B, Morgado MG, Watts DH, Weir F, Persing D, Mofenson LM, Veloso VG, Pilotto JH, Joao E, Nielsen-Saines K. Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission. Sex Transm Dis. 2015 Oct; 42(10):554-65. PMID: 26372927; PMCID: PMC4571193 [Available on 10/01/16].
    25. Kojima N, Bristow C, Maecker H, Rosenberg-Hasson Y, Leon SR, Vargas SK, Konda KA, Caceres CF, Klausner JD. Similarities in the Markers of Inflammation Between Men With Syphilis and Women With Increased Risk of HIV Acquisition. Clin Infect Dis. 2016 Jan 15; 62(2):265-6. PMID: 26394671; PMCID: PMC4731406 [Available on 01/15/17].
    26. Podewils LJ, Bantubani N, Bristow C, Bronner LE, Peters A, Pym A, Mametja LD. Completeness and Reliability of the Republic of South Africa National Tuberculosis (TB) Surveillance System. BMC Public Health. 2015 Aug 11; 15:765. PMID: 26259599; PMCID: PMC4542096.
    27. Chipungu C, Veltman JA, Jansen P, Chiliko P, Lossa C, Namarika D, Benner B, Hoffman RM, Bristow C, Klausner JD. Feasibility and Acceptability of Cryptococcal Antigen Screening and Prevalence of Cryptocococcemia in Patients Attending a Resource-Limited HIV/AIDS Clinic in Malawi. J Int Assoc Provid AIDS Care. 2015 Sep-Oct; 14(5):387-90. PMID: 26139095.
      View in: PubMed
    28. Wynn A, Bristow C, Ross D, Schenker I, Klausner JD. A program evaluation report of a rapid scale-up of a high-volume medical male circumcision site, KwaZulu-Natal, South Africa, 2010-2013. BMC Health Serv Res. 2015 Jun 18; 15:235. PMID: 26084777; PMCID: PMC4472417.
    29. Kojima N, Bristow C, Pollock N, Crouse P, Theodore H, Bonhomme J, Gaston CF, Dévieux JG, Pape JW, Klausner JD. Rapid Training and Implementation of the Pollock Technique, a Safe, Effective Newborn Circumcision Procedure, in a Low-Resource Setting. Glob Pediatr Health. 2015; 2:2333794X15589114. PMID: 27335959; PMCID: PMC4784613.
    30. Bristow C, Larson E, Javanbakht M, Huang E, Causer L, Klausner JD. A review of recent advances in rapid point-of-care tests for syphilis. Sex Health. 2015 Apr; 12(2):119-25. PMID: 25622292.
      View in: PubMed
    31. Marlin RW, Young SD, Bristow C, Wilson G, Rodriguez J, Ortiz J, Mathew R, Klausner JD. Piloting an HIV self-test kit voucher program to raise serostatus awareness of high-risk African Americans, Los Angeles. BMC Public Health. 2014 Nov 26; 14:1226. PMID: 25427749; PMCID: PMC4289344.
    32. Bristow C, Konda KA, Wong J, Caceres CF, Klausner JD. Choosing a metric for measurement of pre-exposure prophylaxis. Lancet Infect Dis. 2014 Dec; 14(12):1177-8. PMID: 25455980; PMCID: PMC4507263.
    33. Bristow C, Leon SR, Ramos LB, Vargas SK, Flores JA, Konda KA, Caceres CF, Klausner JD. Laboratory evaluation of a dual rapid immunodiagnostic test for HIV and syphilis infection. J Clin Microbiol. 2015 Jan; 53(1):311-3. PMID: 25378568; PMCID: PMC4290944.
    34. Veltman JA, Bristow C, Klausner JD. Meningitis in HIV-positive patients in sub-Saharan Africa: a review. J Int AIDS Soc. 2014; 17:19184. PMID: 25308903; PMCID: PMC4195174.
    35. Humphries RM, Woo JS, Chung JH, Sokovic A, Bristow C, Klausner JD. Laboratory evaluation of three rapid diagnostic tests for dual detection of HIV and Treponema pallidum antibodies. J Clin Microbiol. 2014 Dec; 52(12):4394-7. PMID: 25297332; PMCID: PMC4313326.
    36. Bristow C, Adu-Sarkodie Y, Ondondo RO, Bukusi EA, Dagnra CA, Oo KY, Pe EH, Khamsay C, Houng le T, Campuzano RV, Estes J, Klausner JD. Multisite Laboratory Evaluation of a Dual Human Immunodeficiency Virus (HIV)/Syphilis Point-of-Care Rapid Test for Simultaneous Detection of HIV and Syphilis Infection. Open Forum Infect Dis. 2014 Mar; 1(1):ofu015. PMID: 25734088; PMCID: PMC4324189.
    37. Jinno S, Anker B, Kaur P, Bristow C, Klausner JD. Predictors of serological failure after treatment in HIV-infected patients with early syphilis in the emerging era of universal antiretroviral therapy use. BMC Infect Dis. 2013 Dec 26; 13:605. PMID: 24369955; PMCID: PMC3877955.
    38. Bristow C, Desgrottes T, Cutler L, Cutler D, Devarajan K, Ocheretina O, Pape JW, Klausner JD. The aetiology of vaginal symptoms in rural Haiti. Int J STD AIDS. 2014 Aug; 25(9):669-75. PMID: 24352116; PMCID: PMC4712119.
    39. Dilraj A, Bristow C, Connolly C, Margot B, Dlamini S, Podewils LJ. Validation of sputum smear results in the Electronic TB Register for the management of tuberculosis, South Africa. Int J Tuberc Lung Dis. 2013 Oct; 17(10):1317-21. PMID: 24025384; PMCID: PMC4615998.
    40. Bristow C, Podewils LJ, Bronner LE, Bantubani N, Walt Mv, Peters A, Mametja D. TB tracer teams in South Africa: knowledge, practices and challenges of tracing TB patients to improve adherence. BMC Public Health. 2013 Sep 04; 13:801. PMID: 24007294; PMCID: PMC3846832.
    41. Bristow C, Dilraj A, Margot B, Podewils LJ. Lack of patient registration in the electronic TB register for sputum smear-positive patients in KwaZulu-Natal, South Africa. Tuberculosis (Edinb). 2013 Sep; 93(5):567-8. PMID: 23769141; PMCID: PMC4616016.
    42. Bristow C, Larson E, Vilakazi-Nhlapo AK, Wilson M, Klausner JD. Scale-up of isoniazid preventive therapy in PEPFAR-assisted clinical sites in South Africa. Int J Tuberc Lung Dis. 2012 Aug; 16(8):1020-2. PMID: 22668595.
      View in: PubMed