Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Charles King

    TitleAssociate Researcher
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0983
    CA La Jolla 92093
    Phone858-822-4720
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Proteomic Analysis of PI 3-Kinase Signaling in Islet
      NIH/NIDDK R21DK071228Apr 1, 2005 - Mar 31, 2008
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Browne SH, Diaz-Perez JA, Preziosi M, King C, Jones GA, Jain S, Sun X, Reid EG, VandenBerg S, Wang HY. mTOR activity in AIDS-related diffuse large B-cell lymphoma. PLoS One. 2017; 12(2):e0170771. PMID: 28192480.
        View in: PubMed
      2. Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, Honda TK, Wang-Rodriguez J, Xuan Y, Korrapati A, Yu V, Singh P, Grandis JR, King C, Lippman SM, Wang XQ, Hinton A, Ongkeko WM. The non-coding landscape of head and neck squamous cell carcinoma. Oncotarget. 2016 08 09; 7(32):51211-51222. PMID: 27323410.
        View in: PubMed
      3. Hayek A, King C. Brief review: cell replacement therapies to treat type 1 diabetes mellitus. Clin Diabetes Endocrinol. 2016; 2:4. PMID: 28702240.
        View in: PubMed
      4. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King C, Newton AC. Protein kinase C? exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. PMID: 26635352; PMCID: PMC4888060.
      5. King C, Obonyo M. Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1). BMC Microbiol. 2015 Oct 21; 15:222. PMID: 26487493; PMCID: PMC4618363.
      6. Fogel GB, Kai ZS, Zargar S, Hinton A, Jones GA, Wong AS, Ficici SG, Lopez AD, King C. MicroRNA dynamics during human embryonic stem cell differentiation to pancreatic endoderm. Gene. 2015 Dec 15; 574(2):359-70. PMID: 26297998.
        View in: PubMed
      7. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King C, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. PMID: 26187466; PMCID: PMC4571940.
      8. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King C, Sastri M, Herberg FW, Taylor SS. Single Turnover Autophosphorylation Cycle of the PKA RIIƟ Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466; PMCID: PMC4497662.
      9. Mitchell M, Mali S, King C, Bark SJ. Enhancing MALDI time-of-flight mass spectrometer performance through spectrum averaging. PLoS One. 2015; 10(3):e0120932. PMID: 25798583; PMCID: PMC4370844.
      10. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King C, Nizet V, Nigam V. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-?B signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. PMID: 25630970; PMCID: PMC4771066.
      11. Hinton A, Hunter SE, Afrikanova I, Jones GA, Lopez AD, Fogel GB, Hayek A, King C. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells. 2014 Sep; 32(9):2360-72. PMID: 24805944.
        View in: PubMed
      12. Lopez AD, Kayali AG, Hayek A, King C. Isolation, culture, and imaging of human fetal pancreatic cell clusters. J Vis Exp. 2014 May 18; (87). PMID: 24895054; PMCID: PMC4193289.
      13. King C. Cardioprotection by encapsulated GLP-1-producing mesenchymal stem cells. Regen Med. 2013 Mar; 8(2):117-8. PMID: 23596646.
        View in: PubMed
      14. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King C, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor SS. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
      15. Sachlos E, Bollenbach T, Kerstetter-Fogle AE, King C. The dark side of scaffolds. Regen Med. 2013 Jan; 8(1):17. PMID: 23259801.
        View in: PubMed
      16. King C. Mesenchymal stem cells: protectors of islets? Regen Med. 2013 Jan; 8(1):20-1. PMID: 23390634.
        View in: PubMed
      17. King C. Targeting innate immunity to treat long-term type 1 diabetes. Regen Med. 2012 Nov; 7(6):753-4. PMID: 23304723.
        View in: PubMed
      18. Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King C. The SDF-1a/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS One. 2012; 7(6):e38721. PMID: 22761699; PMCID: PMC3382144.
      19. King C, Sachlos E, Kerstetter-Fogle AE, Bollenbach T. Research highlights: Highlights from the latest articles in regenerative medicine. Regen Med. 2012 May; 7(3):275-7. PMID: 22594320.
        View in: PubMed
      20. Hinton A, Hunter S, Reyes G, Fogel GB, King C. From pluripotency to islets: miRNAs as critical regulators of human cellular differentiation. Adv Genet. 2012; 79:1-34. PMID: 22989764.
        View in: PubMed
      21. King C, Sastri M, Chang P, Pennypacker J, Taylor SS. The rate of NF-?B nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One. 2011 Apr 27; 6(4):e18713. PMID: 21556136; PMCID: PMC3083391.
      22. Powers ME, Smith PA, Roberts TC, Fowler BJ, King C, Trauger SA, Siuzdak G, Romesberg FE. Type I signal peptidase and protein secretion in Staphylococcus epidermidis. J Bacteriol. 2011 Jan; 193(2):340-8. PMID: 21075926; PMCID: PMC3019839.
      23. Hinton A, Afrikanova I, Wilson M, King C, Maurer B, Yeo GW, Hayek A, Pasquinelli AE. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. Stem Cells Dev. 2010 Jun; 19(6):797-807. PMID: 19807270.
        View in: PubMed
      24. King C. Culture and preparation of human embryonic stem cells for proteomics-based applications. Methods Mol Biol. 2010; 584:151-77. PMID: 19907977.
        View in: PubMed
      25. King C, Bouic K, Friedmann T. A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Sci. 2009 Aug 11; 7:28. PMID: 19664293; PMCID: PMC2732595.
      26. Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King C, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009 Aug 03; 206(8):1691-9. PMID: 19596804; PMCID: PMC2722167.
      27. Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King C, Maedler K. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009 Feb; 9(2):125-39. PMID: 19187771.
        View in: PubMed
      28. De Jaco A, Comoletti D, King C, Taylor P. Trafficking of cholinesterases and neuroligins mutant proteins. An association with autism. Chem Biol Interact. 2008 Sep 25; 175(1-3):349-51. PMID: 18555979; PMCID: PMC2692863.
      29. King C, Beattie GM, Lopez AD, Hayek A. Generation of definitive endoderm from human embryonic stem cells cultured in feeder layer-free conditions. Regen Med. 2008 Mar; 3(2):175-80. PMID: 18307401.
        View in: PubMed
      30. Guo LT, Friedmann T, King C. Partial characterization of the proteome of the mouse striatum. Proteomics. 2007 Nov; 7(21):3867-9. PMID: 17922512.
        View in: PubMed
      31. Schauble S, King C, Darshi M, Koller A, Shah K, Taylor SS. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem. 2007 May 18; 282(20):14952-9. PMID: 17242405.
        View in: PubMed
      32. Beattie GM, Lopez AD, Bucay N, Hinton A, Firpo MT, King C, Hayek A. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells. 2005 Apr; 23(4):489-95. PMID: 15790770.
        View in: PubMed
      33. Schaffner A, King C, Schaer D, Guiney DG. Induction and antimicrobial activity of platelet basic protein derivatives in human monocytes. J Leukoc Biol. 2004 Nov; 76(5):1010-8. PMID: 15316029.
        View in: PubMed
      34. King C, Newton AC. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004 Sep 03; 279(36):37518-27. PMID: 15210700.
        View in: PubMed
      35. Zenke FT, Krendel M, DerMardirossian C, King C, Bohl BP, Bokoch GM. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem. 2004 Apr 30; 279(18):18392-400. PMID: 14970201.
        View in: PubMed
      36. Humphrey RK, Beattie GM, Lopez AD, Bucay N, King C, Firpo MT, Rose-John S, Hayek A. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells. 2004; 22(4):522-30. PMID: 15277698.
        View in: PubMed
      37. Zhou GL, Zhuo Y, King C, Fryer BH, Bokoch GM, Field J. Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol. 2003 Nov; 23(22):8058-69. PMID: 14585966; PMCID: PMC262366.
      38. Puto LA, Pestonjamasp K, King C, Bokoch GM. p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. J Biol Chem. 2003 Mar 14; 278(11):9388-93. PMID: 12522133.
        View in: PubMed
      39. Hayashi M, Tapping RI, Chao TH, Lo JF, King C, Yang Y, Lee JD. BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. J Biol Chem. 2001 Mar 23; 276(12):8631-4. PMID: 11254654.
        View in: PubMed
      40. King C, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem. 2000 Dec 29; 275(52):41201-9. PMID: 10995762.
        View in: PubMed
      41. King C, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J Biol Chem. 2000 Jun 16; 275(24):18108-13. PMID: 10748151.
        View in: PubMed
      42. King C, Sanders LC, Bokoch GM. In vivo activity of wild-type and mutant PAKs. Methods Enzymol. 2000; 325:315-27. PMID: 11036614.
        View in: PubMed
      43. King C, Reilly AM, Knaus UG. Purification and in vitro activities of p21-activated kinases. Methods Enzymol. 2000; 325:155-66. PMID: 11036601.
        View in: PubMed
      44. Zenke FT, King C, Bohl BP, Bokoch GM. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem. 1999 Nov 12; 274(46):32565-73. PMID: 10551809.
        View in: PubMed
      45. Bokoch GM, Reilly AM, Daniels RH, King C, Olivera A, Spiegel S, Knaus UG. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem. 1998 Apr 03; 273(14):8137-44. PMID: 9525917.
        View in: PubMed