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Charles King

TitleAssociate Researcher
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0983
La Jolla CA 92093
Phone858-822-4720
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    Collapse Research 
    Collapse Research Activities and Funding
    Proteomic Analysis of PI 3-Kinase Signaling in Islet
    NIH/NIDDK R21DK071228Apr 1, 2005 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Browne SH, Diaz-Perez JA, Preziosi M, King CC, Jones GA, Jain S, Sun X, Reid EG, VandenBerg S, Wang HY. mTOR activity in AIDS-related diffuse large B-cell lymphoma. PLoS One. 2017; 12(2):e0170771. PMID: 28192480.
      View in: PubMed
    2. Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, Honda TK, Wang-Rodriguez J, Xuan Y, Korrapati A, Yu V, Singh P, Grandis JR, King CC, Lippman SM, Wang XQ, Hinton A, Ongkeko WM. The non-coding landscape of head and neck squamous cell carcinoma. Oncotarget. 2016 08 09; 7(32):51211-51222. PMID: 27323410.
      View in: PubMed
    3. Hayek A, King CC. Brief review: cell replacement therapies to treat type 1 diabetes mellitus. Clin Diabetes Endocrinol. 2016; 2:4. PMID: 28702240.
      View in: PubMed
    4. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. Protein kinase C? exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. PMID: 26635352; PMCID: PMC4888060.
    5. King CC, Obonyo M. Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1). BMC Microbiol. 2015 Oct 21; 15:222. PMID: 26487493; PMCID: PMC4618363.
    6. Fogel GB, Kai ZS, Zargar S, Hinton A, Jones GA, Wong AS, Ficici SG, Lopez AD, King CC. MicroRNA dynamics during human embryonic stem cell differentiation to pancreatic endoderm. Gene. 2015 Dec 15; 574(2):359-70. PMID: 26297998.
      View in: PubMed
    7. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. PMID: 26187466; PMCID: PMC4571940.
    8. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Single Turnover Autophosphorylation Cycle of the PKA RIIƟ Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466; PMCID: PMC4497662.
    9. Mitchell M, Mali S, King CC, Bark SJ. Enhancing MALDI time-of-flight mass spectrometer performance through spectrum averaging. PLoS One. 2015; 10(3):e0120932. PMID: 25798583; PMCID: PMC4370844.
    10. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-?B signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. PMID: 25630970; PMCID: PMC4771066.
    11. Hinton A, Hunter SE, Afrikanova I, Jones GA, Lopez AD, Fogel GB, Hayek A, King CC. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells. 2014 Sep; 32(9):2360-72. PMID: 24805944.
      View in: PubMed
    12. Lopez AD, Kayali AG, Hayek A, King CC. Isolation, culture, and imaging of human fetal pancreatic cell clusters. J Vis Exp. 2014 May 18; (87). PMID: 24895054; PMCID: PMC4193289.
    13. King CC. Cardioprotection by encapsulated GLP-1-producing mesenchymal stem cells. Regen Med. 2013 Mar; 8(2):117-8. PMID: 23596646.
      View in: PubMed
    14. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor SS. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
    15. Sachlos E, Bollenbach T, Kerstetter-Fogle AE, King CC. The dark side of scaffolds. Regen Med. 2013 Jan; 8(1):17. PMID: 23259801.
      View in: PubMed
    16. King CC. Mesenchymal stem cells: protectors of islets? Regen Med. 2013 Jan; 8(1):20-1. PMID: 23390634.
      View in: PubMed
    17. King CC. Targeting innate immunity to treat long-term type 1 diabetes. Regen Med. 2012 Nov; 7(6):753-4. PMID: 23304723.
      View in: PubMed
    18. Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC. The SDF-1a/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS One. 2012; 7(6):e38721. PMID: 22761699; PMCID: PMC3382144.
    19. King CC, Sachlos E, Kerstetter-Fogle AE, Bollenbach T. Research highlights: Highlights from the latest articles in regenerative medicine. Regen Med. 2012 May; 7(3):275-7. PMID: 22594320.
      View in: PubMed
    20. Hinton A, Hunter S, Reyes G, Fogel GB, King CC. From pluripotency to islets: miRNAs as critical regulators of human cellular differentiation. Adv Genet. 2012; 79:1-34. PMID: 22989764.
      View in: PubMed
    21. King CC, Sastri M, Chang P, Pennypacker J, Taylor SS. The rate of NF-?B nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One. 2011 Apr 27; 6(4):e18713. PMID: 21556136; PMCID: PMC3083391.
    22. Powers ME, Smith PA, Roberts TC, Fowler BJ, King CC, Trauger SA, Siuzdak G, Romesberg FE. Type I signal peptidase and protein secretion in Staphylococcus epidermidis. J Bacteriol. 2011 Jan; 193(2):340-8. PMID: 21075926; PMCID: PMC3019839.
    23. Hinton A, Afrikanova I, Wilson M, King CC, Maurer B, Yeo GW, Hayek A, Pasquinelli AE. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. Stem Cells Dev. 2010 Jun; 19(6):797-807. PMID: 19807270.
      View in: PubMed
    24. King CC. Culture and preparation of human embryonic stem cells for proteomics-based applications. Methods Mol Biol. 2010; 584:151-77. PMID: 19907977.
      View in: PubMed
    25. King CC, Bouic K, Friedmann T. A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Sci. 2009 Aug 11; 7:28. PMID: 19664293; PMCID: PMC2732595.
    26. Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009 Aug 03; 206(8):1691-9. PMID: 19596804; PMCID: PMC2722167.
    27. Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009 Feb; 9(2):125-39. PMID: 19187771.
      View in: PubMed
    28. De Jaco A, Comoletti D, King CC, Taylor P. Trafficking of cholinesterases and neuroligins mutant proteins. An association with autism. Chem Biol Interact. 2008 Sep 25; 175(1-3):349-51. PMID: 18555979; PMCID: PMC2692863.
    29. King CC, Beattie GM, Lopez AD, Hayek A. Generation of definitive endoderm from human embryonic stem cells cultured in feeder layer-free conditions. Regen Med. 2008 Mar; 3(2):175-80. PMID: 18307401.
      View in: PubMed
    30. Guo LT, Friedmann T, King CC. Partial characterization of the proteome of the mouse striatum. Proteomics. 2007 Nov; 7(21):3867-9. PMID: 17922512.
      View in: PubMed
    31. Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem. 2007 May 18; 282(20):14952-9. PMID: 17242405.
      View in: PubMed
    32. Beattie GM, Lopez AD, Bucay N, Hinton A, Firpo MT, King CC, Hayek A. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells. 2005 Apr; 23(4):489-95. PMID: 15790770.
      View in: PubMed
    33. Schaffner A, King CC, Schaer D, Guiney DG. Induction and antimicrobial activity of platelet basic protein derivatives in human monocytes. J Leukoc Biol. 2004 Nov; 76(5):1010-8. PMID: 15316029.
      View in: PubMed
    34. King CC, Newton AC. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004 Sep 03; 279(36):37518-27. PMID: 15210700.
      View in: PubMed
    35. Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem. 2004 Apr 30; 279(18):18392-400. PMID: 14970201.
      View in: PubMed
    36. Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo MT, Rose-John S, Hayek A. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells. 2004; 22(4):522-30. PMID: 15277698.
      View in: PubMed
    37. Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J. Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol. 2003 Nov; 23(22):8058-69. PMID: 14585966; PMCID: PMC262366.
    38. Puto LA, Pestonjamasp K, King CC, Bokoch GM. p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. J Biol Chem. 2003 Mar 14; 278(11):9388-93. PMID: 12522133.
      View in: PubMed