Chambers Hughes

TitleAssistant Professor
InstitutionUniversity of California San Diego
DepartmentCenter for Marine Biotechnology and Biomedecine
Address9500 Gilman Drive #0227
La Jolla CA 92093
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    1. Castro-Falcón G, Seiler G, Demir O, Rathinaswamy M, Hamelin D, Hoffmann RM, Makowski S, Letzel AC, Field S, Burke J, Amaro RE, Hughes CC. Neolymphostin A is a Covalent Phosphoinositide-3-kinase (PI3-K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor that Employs an Unusual Electrophilic Vinylogous Ester. J Med Chem. 2018 Oct 31. PMID: 30380865.
      View in: PubMed
    2. Castro-Falcón G, Mill Aacute N Agui Ntilde Aga N, Roullier C, Jensen PR, Hughes CC. Nitrosopyridine probe to detect polyketide natural products with conjugated alkenes: Discovery of novodaryamide and nocarditriene. ACS Chem Biol. 2018 Oct 01. PMID: 30272441.
      View in: PubMed
    3. Patin NV, Floros DJ, Hughes CC, Dorrestein PC, Jensen PR. The role of inter-species interactions in Salinispora specialized metabolism. Microbiology. 2018 Jun 07. PMID: 29877785.
      View in: PubMed
    4. Gallagher KA, Wanger G, Henderson J, Llorente M, Hughes CC, Jensen PR. Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environ Microbiol. 2017 Jun; 19(6):2182-2191. PMID: 28205416.
      View in: PubMed
    5. Reimer D, Hughes CC. Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts. J Nat Prod. 2017 01 27; 80(1):126-133. PMID: 28055208.
      View in: PubMed
    6. Castro-Falcón G, Hahn D, Reimer D, Hughes CC. Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action. ACS Chem Biol. 2016 08 19; 11(8):2328-36. PMID: 27294329.
      View in: PubMed
    7. Alvarez-Mico X, Jensen PR, Fenical W, Hughes CC. Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp. Org Lett. 2013 Mar 01; 15(5):988-91. PMID: 23405849; PMCID: PMC3702164.
    8. Yamanaka K, Ryan KS, Gulder TA, Hughes CC, Moore BS. Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. J Am Chem Soc. 2012 Aug 01; 134(30):12434-7. PMID: 22800473; PMCID: PMC3415713.
    9. Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jul; 55(7):3305-12. PMID: 21502631; PMCID: PMC3122406.
    10. Hughes CC, Fenical W. Antibacterials from the sea. Chemistry. 2010 Nov 08; 16(42):12512-25. PMID: 20845412; PMCID: PMC3071975.
    11. Hughes CC, Kauffman CA, Jensen PR, Fenical W. Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. J Org Chem. 2010 May 21; 75(10):3240-50. PMID: 20405892; PMCID: PMC2884375.
    12. Hughes CC, Fenical W. Total synthesis of the ammosamides. J Am Chem Soc. 2010 Mar 03; 132(8):2528-9. PMID: 20131899; PMCID: PMC2828514.
    13. Nett M, Gulder TA, Kale AJ, Hughes CC, Moore BS. Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem. 2009 Oct 08; 52(19):6163-7. PMID: 19746976; PMCID: PMC2771571.
    14. Hughes CC, Yang YL, Liu WT, Dorrestein PC, La Clair JJ, Fenical W. Marinopyrrole A target elucidation by acyl dye transfer. J Am Chem Soc. 2009 Sep 02; 131(34):12094-6. PMID: 19673475; PMCID: PMC2769490.
    15. Hughes CC, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ. Ammosamides A and B target myosin. Angew Chem Int Ed Engl. 2009; 48(4):728-32. PMID: 19097126; PMCID: PMC2820877.
    16. Hughes CC, MacMillan JB, Gaudêncio SP, Jensen PR, Fenical W. The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angew Chem Int Ed Engl. 2009; 48(4):725-7. PMID: 19090514; PMCID: PMC2819817.
    17. Hughes CC, Prieto-Davo A, Jensen PR, Fenical W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org Lett. 2008 Feb 21; 10(4):629-31. PMID: 18205372; PMCID: PMC2820876.
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