Brian Hempel

Title(s)Postdoctoral Scholar, Cognitive Science
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Presynaptic and Postsynaptic Mesolimbic Dopamine D3 Receptors Play Distinct Roles in Cocaine Versus Opioid Reward in Mice. Biol Psychiatry. 2024 Nov 01; 96(9):752-765. Xi ZX, Bocarsly ME, Galaj E, Hempel B, Teresi C, Shaw M, Bi GH, Jordan C, Linz E, Alton H, Tanda G, Freyberg Z, Alvarez VA, Newman AH. PMID: 38838841; PMCID: PMC11446657.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    2. PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice. Mol Psychiatry. 2023 10; 28(10):4203-4214. Hempel B, Crissman M, Pari S, Klein B, Bi GH, Alton H, Xi ZX. PMID: 37479780; PMCID: PMC10799974.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    3. PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice. Res Sq. 2023 Mar 02. Xi ZX, Hempel B, Crissman M, Pari S, Klein B, Bi GH, Alton H. PMID: 36909477; PMCID: PMC10002816.
      View in: PubMed   Mentions:
    4. Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice. J Neurosci. 2023 01 18; 43(3):373-385. Han X, Liang Y, Hempel B, Jordan CJ, Shen H, Bi GH, Li J, Xi ZX. PMID: 36517243; PMCID: PMC9864584.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    5. A red nucleus-VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use. Sci Adv. 2022 Sep 02; 8(35):eabo1440. He Y, Madeo G, Liang Y, Zhang C, Hempel B, Liu X, Mu L, Liu S, Bi GH, Galaj E, Zhang HY, Shen H, McDevitt RA, Gardner EL, Liu QS, Xi ZX. PMID: 36054363; PMCID: PMC10848951.
      View in: PubMed   Mentions: 10     Fields:    
    6. A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder. Neuropsychopharmacology. 2022 12; 47(13):2309-2318. Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH. PMID: 35879349; PMCID: PMC9309443.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    7. Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research. Transl Psychiatry. 2022 07 18; 12(1):286. Galaj E, Hempel B, Moore A, Klein B, Bi GH, Gardner EL, Seltzman HH, Xi ZX. PMID: 35851573; PMCID: PMC9293959.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    8. Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism. J Neurosci. 2022 03 16; 42(11):2327-2343. Yang HJ, Hempel BJ, Bi GH, He Y, Zhang HY, Gardner EL, Xi ZX. PMID: 35091501; PMCID: PMC8936610.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Receptor mechanisms underlying the CNS effects of cannabinoids: CB1 receptor and beyond. Adv Pharmacol. 2022; 93:275-333. Hempel B, Xi ZX. PMID: 35341569; PMCID: PMC10709991.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    10. Mitochondrial Clk1-iron-DAT regulation pathway: a possible new therapeutic target for methamphetamine use disorder. Acta Pharmacol Sin. 2022 08; 43(8):1887-1888. Hempel B, Xi ZX. PMID: 34873315; PMCID: PMC9343602.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms. Front Pharmacol. 2021; 12:722476. He XH, Galaj E, Bi GH, He Y, Hempel B, Wang YL, Gardner EL, Xi ZX. PMID: 34566647; PMCID: PMC8458938.
      View in: PubMed   Mentions: 16  
    12. Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice. Behav Brain Res. 2021 10 11; 415:113506. Botz-Zapp CA, Foster SL, Pulley DM, Hempel B, Bi GH, Xi ZX, Newman AH, Weinshenker D, Manvich DF. PMID: 34352292; PMCID: PMC8403645.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    13. Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice. Neuropharmacology. 2021 05 15; 189:108538. Zhang HY, Shen H, Gao M, Ma Z, Hempel BJ, Bi GH, Gardner EL, Wu J, Xi ZX. PMID: 33789118; PMCID: PMC8122071.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    14. Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice. Addict Biol. 2021 07; 26(4):e13005. Humburg BA, Jordan CJ, Zhang HY, Shen H, Han X, Bi GH, Hempel B, Galaj E, Baumann MH, Xi ZX. PMID: 33538103; PMCID: PMC9308103.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    15. Dissecting the role of CB1 and CB2 receptors in cannabinoid reward versus aversion using transgenic CB1- and CB2-knockout mice. Eur Neuropsychopharmacol. 2021 02; 43:38-51. Li X, Hempel BJ, Yang HJ, Han X, Bi GH, Gardner EL, Xi ZX. PMID: 33334652; PMCID: PMC7854511.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    16. Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder. Curr Opin Pharmacol. 2021 02; 56:13-21. Tanda G, Hersey M, Hempel B, Xi ZX, Newman AH. PMID: 32927246; PMCID: PMC8247144.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    17. Cross-generational THC Exposure Weakly Attenuates Cocaine's Rewarding Effects in Adult Male Offspring. Physiol Behav. 2020 12 01; 227:113164. Hempel BJ, Crissman ME, Imanalieva A, Melkumyan M, Winston CA, Riley AL. PMID: 32891609.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Pre-conception exposure to THC fails to impact nicotine reward in adult offspring. Pharmacol Biochem Behav. 2020 10; 197:173001. Hempel BJ, Melkumyan M, Crissman ME, Winston CA, Madar J, Riley AL. PMID: 32710886.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    19. Cross-Generational THC Exposure Alters Heroin Reinforcement in Adult Male Offspring. Drug Alcohol Depend. 2020 07 01; 212:107985. Hempel BJ, Crissman ME, Imanalieva A, Melkumyan M, Weiss TD, Winston CA, Riley AL. PMID: 32386920.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    20. Ad-libitum high fat diet consumption during adolescence and adulthood impacts the intravenous self-administration of cocaine in male Sprague-Dawley rats. Exp Clin Psychopharmacol. 2020 Feb; 28(1):32-43. Clasen MM, Sanon TV, Hempel BJ, Nelson KH, Kearns DN, Davidson TL, Riley AL. PMID: 30998057.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    21. Stereoselective effects of the second-generation synthetic cathinone α-pyrrolidinopentiophenone (α-PVP): assessments of conditioned taste avoidance in rats. Psychopharmacology (Berl). 2019 Mar; 236(3):1067-1077. Nelson KH, López-Arnau R, Hempel BJ, To P, Manke HN, Crissman ME, Clasen MM, Rice KC, Riley AL. PMID: 30334086; PMCID: PMC8328279.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    22. An assessment of concurrent cannabidiol and Δ⁹-tetrahydrocannabinol administration in place aversion and taste avoidance conditioning. Exp Clin Psychopharmacol. 2018 04; 26(2):205-213. Hempel BJ, Clasen MM, Nelson KH, Woloshchuk CJ, Riley AL. PMID: 29648861.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Antagonism of the kappa opioid receptor attenuates THC-induced place aversions in adult male Sprague-Dawley rats. Pharmacol Biochem Behav. 2017 Dec; 163:30-35. Clasen MM, Flax SM, Hempel BJ, Cheng K, Rice KC, Riley AL. PMID: 29100992; PMCID: PMC6676491.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    24. Sex as a biological variable: Drug use and abuse. Physiol Behav. 2018 04 01; 187:79-96. Riley AL, Hempel BJ, Clasen MM. PMID: 29030249.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    25. The effects of cannabidiol (CBD) on Δ⁹-tetrahydrocannabinol (THC) self-administration in male and female Long-Evans rats. Exp Clin Psychopharmacol. 2017 08; 25(4):242-248. Wakeford AGP, Wetzell BB, Pomfrey RL, Clasen MM, Taylor WW, Hempel BJ, Riley AL. PMID: 28682102.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    26. Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation 'bath salt' α-pyrrolidinopentiophenone (α-PVP). Pharmacol Biochem Behav. 2017 05; 156:48-55. Nelson KH, Hempel BJ, Clasen MM, Rice KC, Riley AL. PMID: 28427995; PMCID: PMC6155479.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    27. Pre-exposure to cocaine or morphine attenuates taste avoidance conditioning in adolescent rats: Drug specificity in the US pre-exposure effect. Dev Psychobiol. 2017 05; 59(4):486-494. Clasen MM, Hempel BJ, Riley AL. PMID: 28369881.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    28. An assessment of sex differences in Δ9-tetrahydrocannabinol (THC) taste and place conditioning. Pharmacol Biochem Behav. 2017 02; 153:69-75. Hempel BJ, Wakeford AG, Nelson KH, Clasen MM, Woloshchuk CJ, Riley AL. PMID: 27986515.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    29. Delta-9-tetrahydrocannabinol (THC) history fails to affect THC's ability to induce place preferences in rats. Pharmacol Biochem Behav. 2016 May; 144:1-6. Hempel BJ, Wakeford AG, Clasen MM, Friar MA, Riley AL. PMID: 26905371.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
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