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    Beverly Emerson

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Deregulation of CTCF in Epigenetic Gene Silencing in Human Cancers
      NIH/NCI R01CA159354Jun 1, 2011 - May 31, 2016
      Role: Principal Investigator
      Genomic Mapping of C-G Epigenetic Programs in Hematovascular Progenitor Cells
      NIH/NIGMS R01GM078626Sep 20, 2006 - Aug 31, 2010
      Role: Principal Investigator
      Gordon Conference on the Red Cell
      NIH/NIDDK R13DK059827Jul 15, 2001 - Jun 30, 2002
      Role: Principal Investigator
      MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION
      NIH/NCI R13CA091512Jan 12, 2001 - Dec 31, 2001
      Role: Principal Investigator
      FASEB CONFERENCE: CHROMATIN AND TRANSCRIPTION
      NIH/NICHD R13HD035945Jul 1, 1997 - Jun 30, 1998
      Role: Principal Investigator
      Specificity of Mammalian SWI/SNF Remodeling Complexes
      NIH/NIGMS R01GM038760Jul 1, 1987 - Nov 30, 2008
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Peña-Hernández R, Marques M, Hilmi K, Zhao T, Saad A, Alaoui-Jamali MA, Del Rincon SV, Ashworth T, Roy AL, Emerson B, Witcher M. Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E677-86. PMID: 25646466.
        View in: PubMed
      2. Lee MC, Lopez-Diaz FJ, Khan SY, Tariq MA, Dayn Y, Vaske CJ, Radenbaugh AJ, Kim HJ, Emerson B, Pourmand N. Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc Natl Acad Sci U S A. 2014 Nov 4; 111(44):E4726-35. PMID: 25339441.
        View in: PubMed
      3. Krawczyk M, Emerson B. p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-?B complexes. Elife. 2014; 3:e01776. PMID: 24843008.
        View in: PubMed
      4. López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson B. Coordinate transcriptional and translational repression of p53 by TGF-ß1 impairs the stress response. Mol Cell. 2013 May 23; 50(4):552-64. PMID: 23706820.
        View in: PubMed
      5. Balakrishnan SK, Witcher M, Berggren TW, Emerson B. Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. PLoS One. 2012; 7(8):e42424. PMID: 22879976.
        View in: PubMed
      6. Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson B, Tlsty TD, Austin RH. An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer. 2011 May; 11(5):375-82. PMID: 21508974.
        View in: PubMed
      7. Morachis JM, Huang R, Emerson B. Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. Oncotarget. 2011 Jan-Feb; 2(1-2):18-28. PMID: 21378408.
        View in: PubMed
      8. Morachis JM, Murawsky CM, Emerson B. Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev. 2010 Jan 15; 24(2):135-47. PMID: 20040571.
        View in: PubMed
      9. Witcher M, Emerson B. Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell. 2009 May 15; 34(3):271-84. PMID: 19450526.
        View in: PubMed
      10. Kaeser MD, Aslanian A, Dong MQ, Yates JR, Emerson B. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem. 2008 Nov 21; 283(47):32254-63. PMID: 18809673.
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      11. Kaeser MD, Emerson B. Remodeling plans for cellular specialization: unique styles for every room. Curr Opin Genet Dev. 2006 Oct; 16(5):508-12. PMID: 16905306.
        View in: PubMed
      12. Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson B, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev. 2006 Mar 1; 20(5):601-12. PMID: 16510875.
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      13. Ling J, Baibakov B, Pi W, Emerson B, Tuan D. The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter. J Mol Biol. 2005 Jul 29; 350(5):883-96. PMID: 15979088.
        View in: PubMed
      14. Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, Young RA, Montminy M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4459-64. PMID: 15753290.
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      15. Best JL, Amezcua CA, Mayr B, Flechner L, Murawsky CM, Emerson B, Zor T, Gardner KH, Montminy M. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17622-7. PMID: 15585582.
        View in: PubMed
      16. Xu W, Cho H, Kadam S, Banayo EM, Anderson S, Yates JR, Emerson B, Evans RM. A methylation-mediator complex in hormone signaling. Genes Dev. 2004 Jan 15; 18(2):144-56. PMID: 14729568.
        View in: PubMed
      17. Espinosa JM, Verdun RE, Emerson B. p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell. 2003 Oct; 12(4):1015-27. PMID: 14580351.
        View in: PubMed
      18. Kadam S, Emerson B. Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Mol Cell. 2003 Feb; 11(2):377-89. PMID: 12620226.
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      19. Kadam S, Emerson B. Mechanisms of chromatin assembly and transcription. Curr Opin Cell Biol. 2002 Jun; 14(3):262-8. PMID: 12067647.
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      20. Emerson B. Specificity of gene regulation. Cell. 2002 May 3; 109(3):267-70. PMID: 12015975.
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      21. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson B, Montminy M, Evans RM. A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21; 294(5551):2507-11. PMID: 11701890.
        View in: PubMed
      22. Espinosa JM, Emerson B. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell. 2001 Jul; 8(1):57-69. PMID: 11511360.
        View in: PubMed
      23. Zhang W, Kadam S, Emerson B, Bieker JJ. Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol. 2001 Apr; 21(7):2413-22. PMID: 11259590.
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      24. Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson B. Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 2000 Oct 1; 14(19):2441-51. PMID: 11018012.
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      25. Bagga R, Michalowski S, Sabnis R, Griffith JD, Emerson B. HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology. Nucleic Acids Res. 2000 Jul 1; 28(13):2541-50. PMID: 10871404.
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      26. Emerson B, Bagga R. LXIII Cold Spring Harbor Symposium on Quantitative Biology: Mechanisms of Transcription, 3-8 June 1998. Biochim Biophys Acta. 1999 Jan 29; 1423(1):R45-51. PMID: 9989213.
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      27. Armstrong JA, Bieker JJ, Emerson B. A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell. 1998 Oct 2; 95(1):93-104. PMID: 9778250.
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      28. Armstrong JA, Emerson B. Transcription of chromatin: these are complex times. Curr Opin Genet Dev. 1998 Apr; 8(2):165-72. PMID: 9610406.
        View in: PubMed
      29. Bagga R, Armstrong JA, Emerson B. Role of chromatin structure and distal enhancers in tissue-specific transcriptional regulation in vitro. Cold Spring Harb Symp Quant Biol. 1998; 63:569-76. PMID: 10384322.
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      30. Barton MC, Madani N, Emerson B. Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro. Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7257-62. PMID: 9207078.
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      31. Bagga R, Emerson B. An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro. Genes Dev. 1997 Mar 1; 11(5):629-39. PMID: 9119227.
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      32. Armstrong JA, Emerson B. NF-E2 disrupts chromatin structure at human beta-globin locus control region hypersensitive site 2 in vitro. Mol Cell Biol. 1996 Oct; 16(10):5634-44. PMID: 8816476.
        View in: PubMed
      33. Barton MC, Emerson B. Regulated gene expression in reconstituted chromatin and synthetic nuclei. Methods Enzymol. 1996; 274:299-312. PMID: 8902814.
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      34. Barton MC, Emerson B. Regulated expression of the beta-globin gene locus in synthetic nuclei. Genes Dev. 1994 Oct 15; 8(20):2453-65. PMID: 7958909.
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      35. Barton MC, Madani N, Emerson B. The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled beta-globin genes. Genes Dev. 1993 Sep; 7(9):1796-809. PMID: 8370527.
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      36. Fong TC, Emerson B. The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized beta-globin TATA box. Genes Dev. 1992 Apr; 6(4):521-32. PMID: 1559609.
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      37. Barton MC, Hoekstra MF, Emerson B. Site-directed, recombination-mediated mutagenesis of a complex gene locus. Nucleic Acids Res. 1990 Dec 25; 18(24):7349-55. PMID: 2175433.
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      38. Emerson B, Nickol JM, Fong TC. Erythroid-specific activation and derepression of the chick beta-globin promoter in vitro. Cell. 1989 Jun 30; 57(7):1189-200. PMID: 2736626.
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      39. Emerson B, Nickol JM, Jackson PD, Felsenfeld G. Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4786-90. PMID: 3474625.
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      40. Emerson B, Lewis CD, Felsenfeld G. Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain. Cell. 1985 May; 41(1):21-30. PMID: 2986843.
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      41. Emerson B, Roeder RG. DNA sequences and transcription factor interactions of active and inactive forms of mammalian 5 S RNA genes. J Biol Chem. 1984 Jun 25; 259(12):7926-35. PMID: 6203900.
        View in: PubMed
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