Loading...

Ayako Makino

Title(s)Associate Professor In Residence, Medicine
SchoolHealth Sciences
Phone858-246-5790
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Role of Gap Junction in Hypoxia-induced Pulmonary Hypertension
    NIH/NHLBI R01HL146764May 1, 2019 - Apr 30, 2023
    Role: Principal Investigator
    Coronary Endothelial Cell Dysfunction in Diabetes: Role of HuR
    NIH/NHLBI R01HL142214Mar 1, 2018 - Jan 31, 2022
    Role: Principal Investigator
    Ion Channels and Membrane Receptors in Pulmonary Arterial Hypertension
    NIH/NHLBI R35HL135807Jan 15, 2017 - Dec 31, 2023
    Role: Co-Investigator
    Cellular and Molecular Mechanisms of Coronary Endothelial Dysfunction in Diabetes
    NIH/NHLBI R01HL115578Jul 3, 2012 - Jun 30, 2016
    Role: Principal Investigator
    Mechanisms of coronary endothelial dysfunction in diabetes
    NIH/NIDDK K01DK083506Apr 1, 2009 - Mar 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Tang H, Wu K, Wang J, Vinjamuri S, Gu Y, Song S, Wang Z, Zhang Q, Balistrieri A, Ayon RJ, Rischard F, Vanderpool R, Chen J, Zhou G, Desai AA, Black SM, Garcia JGN, Yuan JX, Makino A. Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. JACC Basic Transl Sci. 2018 Dec; 3(6):744-762. PMID: 30623134.
      View in: PubMed
    2. Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, Jiang Q, Li M, Chen Y, Carr SG, Wu K, Zhang Q, Balistrieri A, Wang C, Song S, Ayon RJ, Desai AA, Black SM, Garcia JGN, Makino A, Yuan JX, Lu W, Wang J. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 01; 316(1):L216-L228. PMID: 30358436.
      View in: PubMed
    3. Willson C, Watanabe M, Tsuji-Hosokawa A, Makino A. Pulmonary vascular dysfunction in metabolic syndrome. J Physiol. 2019 Feb; 597(4):1121-1141. PMID: 30125956.
      View in: PubMed
    4. Pan M, Han Y, Basu A, Dai A, Si R, Willson C, Balistrieri A, Scott BT, Makino A. Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice. Am J Physiol Cell Physiol. 2018 06 01; 314(6):C732-C740. PMID: 29513568.
      View in: PubMed
    5. Whitaker ME, Nair V, Sinari S, Dherange PA, Natarajan B, Trutter L, Brittain EL, Hemnes AR, Austin ED, Patel K, Black SM, Garcia JGN, Yuan Md PhD JX, Vanderpool RR, Rischard F, Makino A, Bedrick EJ, Desai AA. Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension. Am J Med. 2018 Jun; 131(6):702.e7-702.e13. PMID: 29421689.
      View in: PubMed
    6. Song S, Carr SG, McDermott KM, Rodriguez M, Babicheva A, Balistrieri A, Ayon RJ, Wang J, Makino A, Yuan JX. STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension. Hypertension. 2018 03; 71(3):518-529. PMID: 29358461.
      View in: PubMed
    7. Sudhahar V, Okur MN, Bagi Z, O'Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, Fukai T. Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2018 03; 38(3):529-541. PMID: 29301787.
      View in: PubMed
    8. He X, Song S, Ayon RJ, Balisterieri A, Black SM, Makino A, Wier WG, Zang WJ, Yuan JX. Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C504-C517. PMID: 29351410.
      View in: PubMed
    9. Tang H, Babicheva A, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX. Endothelial HIF-2a contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2018 02 01; 314(2):L256-L275. PMID: 29074488.
      View in: PubMed
    10. Wu K, Zhang Q, Wu X, Lu W, Tang H, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z, McDermott KM, Balistrieri A, Wang C, Black SM, Garcia JGN, Makino A, Yuan JX, Wang J. Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol. 2017 Nov; 174(22):4155-4172. PMID: 28849593.
      View in: PubMed
    11. Pan M, Han Y, Si R, Guo R, Desai A, Makino A. Hypoxia-induced pulmonary hypertension in type 2 diabetic mice. Pulm Circ. 2017 Mar; 7(1):175-185. PMID: 28680577.
      View in: PubMed
    12. Guo R, Si R, Scott BT, Makino A. Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C398-C406. PMID: 28122731.
      View in: PubMed
    13. Song S, Ayon RJ, Yamamura A, Yamamura H, Dash S, Babicheva A, Tang H, Sun X, Cordery AG, Khalpey Z, Black SM, Desai AA, Rischard F, McDermott KM, Garcia JG, Makino A, Yuan JX. Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol. 2017 03 01; 312(3):L309-L325. PMID: 27979859.
      View in: PubMed
    14. Smith KA, Ayon RJ, Tang H, Makino A, Yuan JX. Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. Front Physiol. 2016; 7:517. PMID: 27867361.
      View in: PubMed
    15. Luo S, Truong AH, Makino A. Isolation of Mouse Coronary Endothelial Cells. J Vis Exp. 2016 07 03; (113). PMID: 27404385.
      View in: PubMed
    16. Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg DR, Chen J, Gu Y, Pohl NM, Zhou T, Jiménez-Pérez L, Ayon RJ, Desai AA, Goltzman D, Rischard F, Khalpey Z, Black SM, Garcia JG, Makino A, Yuan JX. Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L846-59. PMID: 26968768.
      View in: PubMed
    17. Song S, Jacobson KN, McDermott KM, Reddy SP, Cress AE, Tang H, Dudek SM, Black SM, Garcia JG, Makino A, Yuan JX. ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol. 2016 Jan 15; 310(2):C99-114. PMID: 26491047.
      View in: PubMed
    18. Han Y, Cho YE, Ayon R, Guo R, Youssef KD, Pan M, Dai A, Yuan JX, Makino A. SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L1027-36. PMID: 26361875.
      View in: PubMed
    19. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. PMID: 25569851; PMCID: PMC4566064.
    20. Makino A, Dai A, Han Y, Youssef KD, Wang W, Donthamsetty R, Scott BT, Wang H, Dillmann WH. O-GlcNAcase overexpression reverses coronary endothelial cell dysfunction in type 1 diabetic mice. Am J Physiol Cell Physiol. 2015 Nov 01; 309(9):C593-9. PMID: 26269457; PMCID: PMC4628934 [Available on 11/01/16].
    21. Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX. Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. Am J Physiol Cell Physiol. 2015 Apr 15; 308(8):C581-93. PMID: 25673771.
      View in: PubMed
    22. Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15; 308(2):L208-20. PMID: 25416384.
      View in: PubMed
    23. Song S, Yamamura A, Yamamura H, Ayon RJ, Smith KA, Tang H, Makino A, Yuan JX. Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Aug 15; 307(4):C373-83. PMID: 24920677.
      View in: PubMed
    24. Suarez J, Wang H, Scott BT, Ling H, Makino A, Swanson E, Brown JH, Suarez JA, Feinstein S, Diaz-Juarez J, Dillmann WH. In vivo selective expression of thyroid hormone receptor a1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 01; 307(3):R340-6. PMID: 24848360; PMCID: PMC4121632.
    25. Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T, Feng X, Oda K, Miyajima A, Makino A, Iwai M, Fujita T, Yokoyama U, Okumura S, Sato M, Eguchi H, Tohnai I, Ishikawa Y. Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. J Physiol Sci. 2014 May; 64(3):177-83. PMID: 24619404.
      View in: PubMed
    26. Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Xie LH, Feng X, Oda K, Makino A, Fujita T, Yokoyama U, Iwatsubo M, Chen S, Goydos JS, Ishikawa Y, Iwatsubo K. Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration. PLoS One. 2014; 9(2):e89292. PMID: 24586666.
      View in: PubMed
    27. Cho YE, Basu A, Dai A, Heldak M, Makino A. Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice. Am J Physiol Cell Physiol. 2013 Nov 15; 305(10):C1033-40. PMID: 23986204.
      View in: PubMed
    28. Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15; 305(2):L154-64. PMID: 23686856.
      View in: PubMed
    29. Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol. 2013 Jun 01; 304(11):C1042-52. PMID: 23426966.
      View in: PubMed
    30. Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wan J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX. Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells. Circ Res. 2013 Feb 15; 112(4):640-50. PMID: 23300272.
      View in: PubMed
    31. Sasaki K, Donthamsetty R, Heldak M, Cho YE, Scott BT, Makino A. VDAC: old protein with new roles in diabetes. Am J Physiol Cell Physiol. 2012 Nov 15; 303(10):C1055-60. PMID: 22972802.
      View in: PubMed
    32. Yue L, Bian JT, Grizelj I, Cavka A, Phillips SA, Makino A, Mazzone T. Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase. Hypertension. 2012 Oct; 60(4):1040-6. PMID: 22914792.
      View in: PubMed
    33. Estrada IA, Donthamsetty R, Debski P, Zhou MH, Zhang SL, Yuan JX, Han W, Makino A. STIM1 restores coronary endothelial function in type 1 diabetic mice. Circ Res. 2012 Oct 12; 111(9):1166-75. PMID: 22896585.
      View in: PubMed
    34. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012 Aug 03; 111(4):469-81. PMID: 22730443.
      View in: PubMed
    35. Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I. The role of oxysterols in control of endothelial stiffness. J Lipid Res. 2012 Jul; 53(7):1348-58. PMID: 22496390.
      View in: PubMed
    36. Makino A, Wang H, Scott BT, Yuan JX, Dillmann WH. Thyroid hormone receptor-a and vascular function. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1346-52. PMID: 22322976; PMCID: PMC3361953.
    37. Pangare M, Makino A. Mitochondrial function in vascular endothelial cell in diabetes. J Smooth Muscle Res. 2012; 48(1):1-26. PMID: 22504486.
      View in: PubMed
    38. Yao W, Mu W, Zeifman A, Lofti M, Remillard CV, Makino A, Perkins DL, Garcia JG, Yuan JX, Zhang W. Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells. Pulm Circ. 2011 Jul-Sep; 1(3):405-18. PMID: 22140631.
      View in: PubMed
    39. Makino A, Firth AL, Yuan JX. Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr Physiol. 2011 Jul; 1(3):1555-602. PMID: 23733654.
      View in: PubMed
    40. Ko EA, Song MY, Donthamsetty R, Makino A, Yuan JX. Tension Measurement in Isolated Rat and Mouse Pulmonary Artery. Drug Discov Today Dis Models. 2010; 7(3-4):123-130. PMID: 23175638.
      View in: PubMed
    41. Song MY, Makino A, Yuan JX. Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. Antioxid Redox Signal. 2011 Sep 15; 15(6):1549-65. PMID: 21126186.
      View in: PubMed
    42. Makino A, Suarez J, Gawlowski T, Han W, Wang H, Scott BT, Dillmann WH. Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1296-302. PMID: 21346246; PMCID: PMC3119148.
    43. Song MY, Makino A, Yuan JX. STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension. Pulm Circ. 2011; 1(1):84-94. PMID: 21709766.
      View in: PubMed
    44. Makino A, Scott BT, Dillmann WH. Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia. 2010 Aug; 53(8):1783-94. PMID: 20461356; PMCID: PMC2892085.
    45. Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW, Thistlethwaite PA. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med. 2009 Nov; 15(11):1289-97. PMID: 19855400; PMCID: PMC2780347.
    46. Makino A, Suarez J, Wang H, Belke DD, Scott BT, Dillmann WH. Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy. Endocrinology. 2009 Apr; 150(4):2008-15. PMID: 19074585; PMCID: PMC2659277.
    47. Suarez J, Hu Y, Makino A, Fricovsky E, Wang H, Dillmann WH. Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1561-8. PMID: 19060297; PMCID: PMC2603561.
    48. Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1529-38. PMID: 18689502; PMCID: PMC2593496.
    49. Makino A, Platoshyn O, Suarez J, Yuan JX, Dillmann WH. Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C221-30. PMID: 18463230; PMCID: PMC2493564.
    50. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. PMID: 18040067.
      View in: PubMed
    51. Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX. Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H220-8. PMID: 17982012.
      View in: PubMed
    52. Makino A, Shin HY, Komai Y, Fukuda S, Coughlin M, Sugihara-Seki M, Schmid-Schönbein GW. Mechanotransduction in leukocyte activation: a review. Biorheology. 2007; 44(4):221-49. PMID: 18094448.
      View in: PubMed
    53. Kamata K, Makino A, Kanie N, Oda S, Matsumoto T, Kobayashi T, Kikuchi T, Nishimura M, Honda T. Effects of anthocyanidin derivative (HK-008) on relaxation in rat perfused mesenterial bed. J Smooth Muscle Res. 2006 Jun; 42(2-3):75-88. PMID: 17001114.
      View in: PubMed
    54. Makino A, Prossnitz ER, Bünemann M, Wang JM, Yao W, Schmid-Schönbein GW. G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am J Physiol Cell Physiol. 2006 Jun; 290(6):C1633-9. PMID: 16436471.
      View in: PubMed
    55. Makino A, Glogauer M, Bokoch GM, Chien S, Schmid-Schönbein GW. Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am J Physiol Cell Physiol. 2005 Apr; 288(4):C863-71. PMID: 15561759.
      View in: PubMed
    56. Makino A, Skelton MM, Zou AP, Cowley AW. Increased renal medullary H2O2 leads to hypertension. Hypertension. 2003 Jul; 42(1):25-30. PMID: 12782642.
      View in: PubMed
    57. Makino A, Kamata K. Effects of chronic administration of L-arginine on vasoactive responses induced by endothelin-1 and its plasma level in streptozotocin-induced diabetic rats. J Smooth Muscle Res. 2002 Oct; 38(4-5):101-15. PMID: 12596889.
      View in: PubMed
    58. Makino A, Skelton MM, Zou AP, Roman RJ, Cowley AW. Increased renal medullary oxidative stress produces hypertension. Hypertension. 2002 Feb; 39(2 Pt 2):667-72. PMID: 11882628.
      View in: PubMed
    59. Kuroda Y, Nakata M, Makino A, Matsumoto A, Ohashi K, Itahashi K, Takeuchi F, Goto M, Kojima N, Mizuochi T. Structural studies on IgG oligosaccharides of patients with primary Sjögren's syndrome. Glycoconj J. 2002 Jan; 19(1):23-31. PMID: 12652077.
      View in: PubMed
    60. Makino A, Oda S, Kamata K. Mechanisms underlying increased release of endothelin-1 from aorta in diabetic rats. Peptides. 2001 Apr; 22(4):639-45. PMID: 11311735.
      View in: PubMed
    61. Makino A, Ohuchi K, Kamata K. Mechanisms underlying the attenuation of endothelium-dependent vasodilatation in the mesenteric arterial bed of the streptozotocin-induced diabetic rat. Br J Pharmacol. 2000 Jun; 130(3):549-56. PMID: 10821782.
      View in: PubMed
    62. Makino A, Kamata K. Time-course changes in plasma endothelin-1 and its effects on the mesenteric arterial bed in streptozotocin-induced diabetic rats. Diabetes Obes Metab. 2000 Jan; 2(1):47-55. PMID: 11220354.
      View in: PubMed
    63. Makino A, Kamata K. Possible modulation by endothelin-1, nitric oxide, prostaglandin I2 and thromboxane A2 of vasoconstriction induced by an alpha-agonist in mesenteric arterial bed from diabetic rats. Diabetologia. 1998 Dec; 41(12):1410-8. PMID: 9867207.
      View in: PubMed
    64. Makino A, Kamata K. Elevated plasma endothelin-1 level in streptozotocin-induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin-1. Br J Pharmacol. 1998 Mar; 123(6):1065-72. PMID: 9559887.
      View in: PubMed
    65. Kamata K, Makino A. A comparative study on the rat aorta and mesenteric arterial bed of the possible role of nitric oxide in the desensitization of the vasoconstrictor response to an alpha 1-adrenoceptor agonist. Br J Pharmacol. 1997 Apr; 120(7):1221-8. PMID: 9105696.
      View in: PubMed