Antonio De Maio

Title(s)Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    Dr. Antonio De Maio is professor and a member of the Biomedical Sciences Graduate Program (BMS) at UC San Diego.

    A graduate of the Central University of Venezuela in Caracas, Dr. Antonio De Maio received his PhD from the Weizmann Institute of Science in Rehovot, Israel. Dr. Antonio De Maio joined the faculty at UC San Diego School of Medicine in January 2006.

    Prior to that, he was an Associate Professor and Research Director for the Division of Pediatric Surgery at Johns Hopkins University. While at Hopkins, Dr. De Maio led the Committee for the Recruitment of Under-represented Minorities to Graduate Programs and the Post-baccalaureate Research Education Program (PREP). At UC San Diego, Dr. De Maio continues to be very active in increasing student diversity in graduate and medical school.

    He received a Vice Chancellor of Health Sciences 2007 Equal Opportunity/Affirmative Action and Diversity Award. Dr. De Maio is the Director of the Initiative to Maximize Student Diversity (IMSD) Program at UC San Diego, which is supported by NIGMS-NIH.

    Dr. De Maio is a member of the American Association for the Advancement of Science (AAAS), American Society for Cell Biology (ASCB), American Association of Immunologist (AAI), Cell Stress Society International (President-Elect), International Endotoxin Society (IEIIS), PanAmerican Trauma Society, Shock Society, Society of Critical Care Medicine (SCCM), and Society for Advancement of Chicanos and Native Americans in Science (SACNAS).

    The Antonio De Maio Laboratory
    Located on UC San Diego's beautiful La Jolla campus, the Antonio De Maio laboratory is investigating the molecular and genetic bases of the response to injury. Traumatic injury is a major cause of mortality and morbidity in the United States, particularly among children.

    The Antonio De Maio laboratory has found that the response to injury is modulated by several confounding factors including genetic background, sex, age, diet, and environment. The major factor associated with morbidity and mortality injury is an overwhelming inflammatory response.

    The Antonio De Maio group is using mouse genetics to identify genes that regulate the inflammatory process as potential therapeutic targets. In addition, the Antonio De Maio laboratory is studying the role of heat shock proteins in the regulation of the inflammatory response.

    The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels.

    The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels. For more information on their research, please click here.

    Collapse Research 
    Collapse Research Activities and Funding
    Contribution of Cholesterol Homeostasis for Injury Resolution
    NIH R01GM114473Apr 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Heat Shock Proteins and the Stress Observation System
    NIH R01GM098455Sep 1, 2012 - Apr 30, 2018
    Role: Principal Investigator
    UCSD MARC Program
    NIH T34GM087193Jun 1, 2009 - May 31, 2015
    Role: Principal Investigator
    Mentoring Young Minds to Increase Diversity in the Biomedical Research
    NIH R25GM083275Mar 1, 2008 - Jan 31, 2023
    Role: Principal Investigator
    Modifier genes of sepsis
    NIH R01GM073825Sep 1, 2006 - Aug 31, 2011
    Role: Principal Investigator
    GENETIC CONTRIBUTION TO THE STRESS RESPONSE
    NIH R01GM057317Jan 1, 1999 - Dec 31, 2004
    Role: Principal Investigator
    Mechanisms of cytoprotection induced by stress proteins
    NIH R01GM050878Aug 1, 1994 - Jul 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reply to Moldawer, Darden, and Efron's Reply to "Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies". Shock. 2021 Jul 01; 56(1):151-152. De Maio A. PMID: 33156240.
      View in: PubMed   Mentions:    Fields:    
    2. Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease. BMC Med Genomics. 2021 05 24; 14(1):138. Bickler SW, Cauvi DM, Fisch KM, Prieto JM, Sykes AG, Thangarajah H, Lazar DA, Ignacio RC, Gerstmann DR, Ryan AF, Bickler PE, De Maio A. PMID: 34030677.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Human heat shock cognate protein (HSC70/HSPA8) interacts with negatively charged phospholipids by a different mechanism than other HSP70s and brings HSP90 into membranes. Cell Stress Chaperones. 2021 May 18. Dores-Silva PR, Cauvi DM, Coto ALS, Silva NSM, Borges JC, De Maio A. PMID: 34003451.
      View in: PubMed   Mentions:    Fields:    
    4. New insights on human Hsp70-escort protein 1: Chaperone activity, interaction with liposomes, cellular localizations and HSPA's self-assemblies remodeling. Int J Biol Macromol. 2021 Apr 16; 182:772-784. Dores-Silva PR, Kiraly VTR, Moritz MNO, Serrão VHB, Dos Passos PMS, Spagnol V, Teixeira FR, Gava LM, Cauvi DM, Ramos CHI, De Maio A, Borges JC. PMID: 33857516.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Regulation of the Nfkbiz Gene and Its Protein Product IkB? in Animal Models of Sepsis and Endotoxic Shock. Infect Immun. 2021 Mar 17; 89(4). Casas A, Hawisher D, De Guzman CB, Bickler SW, De Maio A, Cauvi DM. PMID: 33431705.
      View in: PubMed   Mentions:    Fields:    
    6. First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020. Cell Stress Chaperones. 2021 03; 26(2):289-295. van Oosten-Hawle P, Bergink S, Blagg B, Brodsky J, Edkins A, Freeman B, Genest O, Hendershot L, Kampinga H, Johnson J, De Maio A, Masison D, Morano K, Multhoff G, Prodromou C, Prahlad V, Scherz-Shouval R, Zhuravleva A, Mollapour M, Truman AW. PMID: 33559835.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies. Shock. 2020 Nov; 54(5):631-632. De Maio A. PMID: 33048867.
      View in: PubMed   Mentions:    Fields:    
    8. Heat shock proteins and the biogenesis of cellular membranes. Cell Stress Chaperones. 2021 01; 26(1):15-18. De Maio A, Hightower LE. PMID: 33083932.
      View in: PubMed   Mentions: 1     Fields:    
    9. COVID-19, acute respiratory distress syndrome (ARDS), and hyperbaric oxygen therapy (HBOT): what is the link? Cell Stress Chaperones. 2020 09; 25(5):717-720. De Maio A, Hightower LE. PMID: 32424591.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    10. Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19? Med Hypotheses. 2020 Nov; 144:110224. Kjellberg A, De Maio A, Lindholm P. PMID: 33254531.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Human HSPA9 (mtHsp70, mortalin) interacts with lipid bilayers containing cardiolipin, a major component of the inner mitochondrial membrane. Biochim Biophys Acta Biomembr. 2020 11 01; 1862(11):183436. Dores-Silva PR, Cauvi DM, Kiraly VTR, Borges JC, De Maio A. PMID: 32781155.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain. Cell Stress Chaperones. 2020 11; 25(6):979-991. Dores-Silva PR, Cauvi DM, Coto ALS, Kiraly VTR, Borges JC, De Maio A. PMID: 32725381.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    13. Human urine exosomes: Another important member of the liquid biopsy family. Methods Enzymol. 2020; 645:195-208. De Maio A. PMID: 33565972.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Differential expression of nuclear genes encoding mitochondrial proteins from urban and rural populations in Morocco. Cell Stress Chaperones. 2020 11; 25(6):847-856. Bickler SW, Prieto JM, Cauvi DM, De Cos V, Nasamran C, Ameh E, Amin S, Nicholson S, Din H, Mocumbi AO, Noormahomed EV, Tellez-Isaias G, Fisch KM, De Maio A. PMID: 32319023.
      View in: PubMed   Mentions:    Fields:    
    15. The Greater Omentum-A Vibrant and Enigmatic Immunologic Organ Involved in Injury and Infection Resolution. Shock. 2020 04; 53(4):384-390. Wang AW, Prieto JM, Cauvi DM, Bickler SW, De Maio A. PMID: 31389904.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Opinion and Reflection do not Blame the Rodent for the Failure of Developing Sepsis Therapies. Shock. 2020 Mar 19. De Maio A. PMID: 32205795.
      View in: PubMed   Mentions:    Fields:    
    17. Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies. Int J Biol Macromol. 2020 Mar 01; 146:320-331. Kiraly VTR, Dores-Silva PR, Serrão VHB, Cauvi DM, De Maio A, Borges JC. PMID: 31899237.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. The Contribution of the Omentum to the Outcome From Sepsis: An Experimental Animal Study. Shock. 2019 12; 52(6):604-611. Wang AW, Cauvi DM, Hawisher D, Reyes T, Coimbra R, Bickler S, De Maio A. PMID: 30601409.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. The small heat shock proteins, HSPB1 and HSPB5, interact differently with lipid membranes. Cell Stress Chaperones. 2019 09; 24(5):947-956. De Maio A, Cauvi DM, Capone R, Bello I, Egberts WV, Arispe N, Boelens W. PMID: 31338686.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. . 2019 07 01; 317(1):R160-R168. Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A. PMID: 31091156.
      View in: PubMed   Mentions:
    21. Reply to "Bacterial Proliferation May Be the Key Component of Sepsis Mortality". Infect Immun. 2018 11; 86(11). De Maio A. PMID: 30361456.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Macrophage reprogramming by negatively charged membrane phospholipids controls infection. FASEB J. 2019 02; 33(2):2995-3009. Cauvi DM, Hawisher D, Dores-Silva PR, Lizardo RE, De Maio A. PMID: 30325674.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Urbanization in Sub-Saharan Africa: Declining Rates of Chronic and Recurrent Infection and Their Possible Role in the Origins of Non-communicable Diseases. World J Surg. 2018 06; 42(6):1617-1628. Bickler SW, Wang A, Amin S, Halbach J, Lizardo R, Cauvi DM, De Maio A. PMID: 29234849.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Isolation and characterization of human urine extracellular vesicles. Cell Stress Chaperones. 2018 09; 23(5):943-953. Liu Z, Cauvi DM, Bernardino EMA, Lara B, Lizardo RE, Hawisher D, Bickler S, De Maio A. PMID: 29796787.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. Memory Loss and the Onset of Alzheimer's Disease Could Be Under the Control of Extracellular Heat Shock Proteins. J Alzheimers Dis. 2018; 63(3):927-934. Arispe N, De Maio A. PMID: 29689729.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Why Antibiotic Treatment Is Not Enough for Sepsis Resolution: an Evaluation in an Experimental Animal Model. Infect Immun. 2017 12; 85(12). Halbach JL, Wang AW, Hawisher D, Cauvi DM, Lizardo RE, Rosas J, Reyes T, Escobedo O, Bickler SW, Coimbra R, De Maio A. PMID: 28947644.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    27. Modulation of Alzheimer's amyloid ß peptide oligomerization and toxicity by extracellular Hsp70. Cell Stress Chaperones. 2018 03; 23(2):269-279. Rivera I, Capone R, Cauvi DM, Arispe N, De Maio A. PMID: 28956268.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. The transition from a rural to an urban environment in Africa alters G protein-coupled receptor signaling. Med Hypotheses. 2016 Oct; 95:49-53. Bickler SW, Lizardo E, Cauvi DM, De Maio A. PMID: 27692166.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. The Molecular Complexity of Sepsis: Expression of Peroxisome Proliferator-Activated Receptor-a, the Tip of the Iceberg? Crit Care Med. 2016 08; 44(8):1617-8. Halbach J, Bickler S, De Maio A. PMID: 27428127.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes. Cell Stress Chaperones. 2016 07; 21(4):609-16. Lopez V, Cauvi DM, Arispe N, De Maio A. PMID: 27075190.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    31. Changes in macrophage function modulated by the lipid environment. Innate Immun. 2016 Apr; 22(3):141-51. Williams MR, Cauvi DM, Rivera I, Hawisher D, De Maio A. PMID: 26951856.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. PMID: 25513848.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    33. The transition from a rural to an urban environment alters expression of the human Ebola virus receptor Neiman-Pick C1: implications for the current epidemic in West Africa. Cell Stress Chaperones. 2015 Mar; 20(2):203-6. Bickler SW, Lizardo RE, De Maio A. PMID: 25477151.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    34. Sustained expression of lipocalin-2 during polymicrobial sepsis. Innate Immun. 2015 Jul; 21(5):477-89. Vazquez DE, Niño DF, De Maio A, Cauvi DM. PMID: 25227123.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis. Shock. 2014 Sep; 42(3):246-55. Cauvi DM, Williams MR, Bermudez JA, Armijo G, De Maio A. PMID: 24978886.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. Vega VL, Crotty Alexander LE, Charles W, Hwang JH, Nizet V, De Maio A. PMID: 25163764.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Itraconazole, a commonly used antifungal, inhibits Fc? receptor-mediated phagocytosis: alteration of Fc? receptor glycosylation and gene expression. Shock. 2014 Jul; 42(1):52-9. Niño DF, Cauvi DM, De Maio A. PMID: 24667630.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Extracellular Hsp70: export and function. Curr Protein Pept Sci. 2014 May; 15(3):225-31. De Maio A. PMID: 24694368.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    39. Interaction of heat shock protein 70 with membranes depends on the lipid environment. Cell Stress Chaperones. 2014 Nov; 19(6):877-86. Armijo G, Okerblom J, Cauvi DM, Lopez V, Schlamadinger DE, Kim J, Arispe N, De Maio A. PMID: 24789271.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    40. What can we learn from elegant clinical studies?*. Crit Care Med. 2014 Apr; 42(4):972-3. De Maio A. PMID: 24633091.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    41. Extracellular heat shock proteins: a new location, a new function. Shock. 2013 Oct; 40(4):239-46. De Maio A, Vazquez D. PMID: 23807250; PMCID: PMC4351735.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    42. Dysfunction of the innate immune system during sepsis: a call for research. Crit Care Med. 2013 Jan; 41(1):364-5. Bickler SW, De Maio A. PMID: 23269155.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012 Aug; 38(3):294-300. Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. PMID: 22683732.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    44. Deletion of scavenger receptor A gene in mice resulted in protection from septic shock and modulation of TLR4 signaling in isolated peritoneal macrophages. Innate Immun. 2013 Feb; 19(1):30-41. Drummond R, Cauvi DM, Hawisher D, Song D, Niño DF, Coimbra R, Bickler S, De Maio A. PMID: 22751446.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    45. Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. Shock. 2012 Jul; 38(1):107-14. Reino DC, Palange D, Feketeova E, Bonitz RP, Xu DZ, Lu Q, Sheth SU, Peña G, Ulloa L, De Maio A, Feinman R, Deitch EA. PMID: 22575992; PMCID: PMC3378823.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    46. Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction. J Biol Chem. 2012 Jun 08; 287(24):19804-15. Cauvi DM, Song D, Vazquez DE, Hawisher D, Bermudez JA, Williams MR, Bickler S, Coimbra R, De Maio A. PMID: 22518839.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    47. Ferruccio Ritossa's scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal. Cell Stress Chaperones. 2012 Mar; 17(2):139-43. De Maio A, Santoro MG, Tanguay RM, Hightower LE. PMID: 22252402.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    48. Sulfur amino acid metabolism limits the growth of children living in environments of poor sanitation. Med Hypotheses. 2011 Sep; 77(3):380-2. Bickler SW, Ring J, De Maio A. PMID: 21658846.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    49. Acute acalculous cholecystitis-like phenotype in scavenger receptor A knock-out mice. J Surg Res. 2012 May 15; 174(2):344-51. Drummond R, Song D, Hawisher D, Wolf PL, Vazquez DE, Nino DF, Coimbra R, Cauvi DM, De Maio A. PMID: 21474146.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    50. Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones. 2011 May; 16(3):235-49. De Maio A. PMID: 20963644.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    51. Stress at the Korean Mountains: meeting report of the 8th International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones. 2011 Mar; 16(2):113-8. De Maio A, Tanguay RM, Kampinga H, Lee E, Kim CD, Hightower L. PMID: 20886326; PMCID: PMC3059799.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. PMID: 20888586.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    53. O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell. 2010 Jun 15; 21(12):1922-36. Zeidan Q, Wang Z, De Maio A, Hart GW. PMID: 20410138.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    54. A new feature of the stress response: increase in endocytosis mediated by Hsp70. Cell Stress Chaperones. 2010 Sep; 15(5):517-27. Vega VL, Charles W, De Maio A. PMID: 20043217; PMCID: PMC3006637.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    55. The antifungal agent itraconazole induces the accumulation of high mannose glycoproteins in macrophages. J Biol Chem. 2009 Jun 19; 284(25):16882-90. Frey T, De Maio A. PMID: 19414590; PMCID: PMC2719324.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    56. Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB J. 2009 Aug; 23(8):2467-77. Schilling D, Gehrmann M, Steinem C, De Maio A, Pockley AG, Abend M, Molls M, Multhoff G. PMID: 19289606; PMCID: PMC2717766.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    57. Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. PLoS One. 2008 Apr 02; 3(4):e1925. Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, De Maio A, Pockley G, Multhoff G. PMID: 18382692; PMCID: PMC2271151.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    58. Acidification enhances peritoneal macrophage phagocytic activity. J Surg Res. 2008 Jun 15; 147(2):206-11. Grabowski JE, Vega VL, Talamini MA, De Maio A. PMID: 18498871.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    59. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol. 2008 Mar 15; 180(6):4299-307. Vega VL, Rodríguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhoff G, Arispe N, De Maio A. PMID: 18322243.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansCells
    60. Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin. Mol Med. 2007 Nov-Dec; 13(11-12):592-604. Frey T, De Maio A. PMID: 17932552.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    61. Peritoneal acidosis mediates immunoprotection in laparoscopic surgery. Surgery. 2007 Sep; 142(3):357-64. Hanly EJ, Aurora AA, Shih SP, Fuentes JM, Marohn MR, De Maio A, Talamini MA. PMID: 17723887.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    62. A quantitative trait loci analysis to map genes involved in lipopolysaccharide-induced inflammatory response: identification of macrophage scavenger receptor 1 as a candidate gene. J Immunol. 2006 Mar 15; 176(6):3767-73. Fulton WB, Reeves RH, Takeya M, De Maio A. PMID: 16517746.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    63. General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock. Clin Vaccine Immunol. 2006 Feb; 13(2):281-8. Fuentes JM, Talamini MA, Fulton WB, Hanly EJ, Aurora AR, De Maio A. PMID: 16467339.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    64. CO2 abdominal insufflation pretreatment increases survival after a lipopolysaccharide-contaminated laparotomy. J Gastrointest Surg. 2006 Jan; 10(1):32-8. Fuentes JM, Hanly EJ, Aurora AR, De Maio A, Shih SP, Marohn MR, Talamini MA. PMID: 16368488.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    65. Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism. Cell Stress Chaperones. 2006; 11(1):44-50. Balakrishnan K, De Maio A. PMID: 16572728; PMCID: PMC1400612.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    66. Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones. 2006; 11(2):108-15. Multhoff G, De Maio A. PMID: 16817316; PMCID: PMC1484512.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    67. Abdominal insufflation with CO2 causes peritoneal acidosis independent of systemic pH. J Gastrointest Surg. 2005 Dec; 9(9):1245-51; discussion 1251-2. Hanly EJ, Aurora AR, Fuentes JM, Shih SP, Marohn MR, De Maio A, Talamini MA. PMID: 16332480.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    68. The severity of cholestatic injury is modulated by the genetic background. Shock. 2005 Nov; 24(5):412-6. Alaish SM, Torres M, Ferlito M, Sun CC, De Maio A. PMID: 16247325.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    69. Increase in phagocytosis after geldanamycin treatment or heat shock: role of heat shock proteins. J Immunol. 2005 Oct 15; 175(8):5280-7. Vega VL, De Maio A. PMID: 16210633.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    70. Anesthesia-specific protection from endotoxic shock is not mediated through the vagus nerve. Surgery. 2005 Oct; 138(4):766-71. Fuentes JM, Hanly EJ, Aurora AR, De Maio A, Talamini MA. PMID: 16269307.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    71. Protection from lethal endotoxic shock after testosterone depletion is linked to chromosome X. Shock. 2005 Oct; 24(4):318-23. Torres MB, Trentzsch H, Stewart D, Mooney ML, Fuentes JM, Saad DF, Reeves RH, De Maio A. PMID: 16205315.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    72. IL-10 plasma levels are elevated after LPS injection in splenectomized A/J mice. J Surg Res. 2005 Nov; 129(1):101-6. Torres MB, Vega VL, Bedri M, Saad D, Trentzsch H, Reeves RH, De Maio A. PMID: 16087192.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    73. An exaggerated inflammatory response after CLP correlates with a negative outcome. J Surg Res. 2005 May 01; 125(1):88-93. Torres MB, De Maio A. PMID: 15836855.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    74. Carbon dioxide pneumoperitoneum-mediated attenuation of the inflammatory response is independent of systemic acidosis. Surgery. 2005 May; 137(5):559-66. Hanly EJ, Bachman SL, Marohn MR, Boden JH, Herring AE, De Maio A, Talamini MA. PMID: 15855930.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    75. Enhanced LPS-induced TNF alpha production in heat-shocked human promonocytic cells: regulation at the translational/post-translational level. Biochim Biophys Acta. 2005 Mar 22; 1743(1-2):20-8. Ferlito M, De Maio A. PMID: 15777836.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock. 2005 Jan; 23(1):11-7. De Maio A, Torres MB, Reeves RH. PMID: 15614125.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    77. Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability. FASEB J. 2004 Nov; 18(14):1636-45. Arispe N, Doh M, Simakova O, Kurganov B, De Maio A. PMID: 15522909.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    78. Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice. Shock. 2004 Sep; 22(3):248-53. Vega VL, De Cabo R, De Maio A. PMID: 15316395.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    79. Gender and age effects on outcome after pediatric traumatic brain injury. Pediatr Crit Care Med. 2004 Mar; 5(2):145-51. Morrison WE, Arbelaez JJ, Fackler JC, De Maio A, Paidas CN. PMID: 14987344.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    80. HSP70 interacts with ribosomal subunits of thermotolerant cells. Shock. 2003 Oct; 20(4):320-5. Cornivelli L, Zeidan Q, De Maio A. PMID: 14501945.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    81. The combination of polymicrobial sepsis and endotoxin results in an inflammatory process that could not be predicted from the independent insults. J Surg Res. 2003 May 15; 111(2):203-8. Trentzsch H, Stewart D, Paidas CN, De Maio A. PMID: 12850463.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    82. CO2 Pneumoperitoneum modifies the inflammatory response to sepsis. Ann Surg. 2003 Mar; 237(3):343-50. Hanly EJ, Mendoza-Sagaon M, Murata K, Hardacre JM, De Maio A, Talamini MA. PMID: 12616117; PMCID: PMC1514307.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    83. Geldanamycin treatment ameliorates the response to LPS in murine macrophages by decreasing CD14 surface expression. Mol Biol Cell. 2003 Feb; 14(2):764-73. Vega VL, De Maio A. PMID: 12589068.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    84. Genetic background conditions the effect of sex steroids on the inflammatory response during endotoxic shock. Crit Care Med. 2003 Jan; 31(1):232-6. Trentzsch H, Stewart D, De Maio A. PMID: 12545021.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    85. Genetic contribution to the septic response in a mouse model. Shock. 2002 Oct; 18(4):342-7. Stewart D, Fulton WB, Wilson C, Monitto CL, Paidas CN, Reeves RH, De Maio A. PMID: 12392278.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    86. Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70. Cell Stress Chaperones. 2002 Oct; 7(4):330-8. Arispe N, Doh M, De Maio A. PMID: 12653477; PMCID: PMC514832.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    87. Gap junctions, homeostasis, and injury. J Cell Physiol. 2002 Jun; 191(3):269-82. De Maio A, Vega VL, Contreras JE. PMID: 12012322.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    88. Accelerated recovery after endotoxic challenge in heat shock-pretreated mice. Am J Physiol Regul Integr Comp Physiol. 2002 May; 282(5):R1374-81. Paidas CN, Mooney ML, Theodorakis NG, De Maio A. PMID: 11959679.
      View in: PubMed   Mentions:
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