Antonio De Maio

InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0739
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    Dr. Antonio De Maio is professor and a member of the Biomedical Sciences Graduate Program (BMS) at UC San Diego.

    A graduate of the Central University of Venezuela in Caracas, Dr. Antonio De Maio received his PhD from the Weizmann Institute of Science in Rehovot, Israel. Dr. Antonio De Maio joined the faculty at UC San Diego School of Medicine in January 2006.

    Prior to that, he was an Associate Professor and Research Director for the Division of Pediatric Surgery at Johns Hopkins University. While at Hopkins, Dr. De Maio led the Committee for the Recruitment of Under-represented Minorities to Graduate Programs and the Post-baccalaureate Research Education Program (PREP). At UC San Diego, Dr. De Maio continues to be very active in increasing student diversity in graduate and medical school.

    He received a Vice Chancellor of Health Sciences 2007 Equal Opportunity/Affirmative Action and Diversity Award. Dr. De Maio is the Director of the Initiative to Maximize Student Diversity (IMSD) Program at UC San Diego, which is supported by NIGMS-NIH.

    Dr. De Maio is a member of the American Association for the Advancement of Science (AAAS), American Society for Cell Biology (ASCB), American Association of Immunologist (AAI), Cell Stress Society International (President-Elect), International Endotoxin Society (IEIIS), PanAmerican Trauma Society, Shock Society, Society of Critical Care Medicine (SCCM), and Society for Advancement of Chicanos and Native Americans in Science (SACNAS).

    The Antonio De Maio Laboratory
    Located on UC San Diego's beautiful La Jolla campus, the Antonio De Maio laboratory is investigating the molecular and genetic bases of the response to injury. Traumatic injury is a major cause of mortality and morbidity in the United States, particularly among children.

    The Antonio De Maio laboratory has found that the response to injury is modulated by several confounding factors including genetic background, sex, age, diet, and environment. The major factor associated with morbidity and mortality injury is an overwhelming inflammatory response.

    The Antonio De Maio group is using mouse genetics to identify genes that regulate the inflammatory process as potential therapeutic targets. In addition, the Antonio De Maio laboratory is studying the role of heat shock proteins in the regulation of the inflammatory response.

    The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels.

    The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels. For more information on their research, please click here.

    Collapse Research 
    Collapse Research Activities and Funding
    Contribution of Cholesterol Homeostasis for Injury Resolution
    NIH/NIGMS R01GM114473Apr 1, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Heat Shock Proteins and the Stress Observation System
    NIH/NIGMS R01GM098455Sep 1, 2012 - Apr 30, 2016
    Role: Principal Investigator
    UCSD MARC Program
    NIH/NIGMS T34GM087193Jun 1, 2009 - May 31, 2015
    Role: Principal Investigator
    Mentoring Young Minds to Increase Diversity in the Biomedical Research
    NIH/NIGMS R25GM083275Mar 1, 2008 - Jan 31, 2023
    Role: Principal Investigator
    Modifier genes of sepsis
    NIH/NIGMS R01GM073825Sep 1, 2006 - Aug 31, 2011
    Role: Principal Investigator
    NIH/NIGMS R01GM057317Jan 1, 1999 - Dec 31, 2004
    Role: Principal Investigator
    Mechanisms of cytoprotection induced by stress proteins
    NIH/NIGMS R01GM050878Aug 1, 1994 - Jul 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bickler SW, Wang A, Amin S, Halbach J, Lizardo R, Cauvi DM, De Maio A. Urbanization in Sub-Saharan Africa: Declining Rates of Chronic and Recurrent Infection and Their Possible Role in the Origins of Non-communicable Diseases. World J Surg. 2018 Jun; 42(6):1617-1628. PMID: 29234849.
      View in: PubMed
    2. Liu Z, Cauvi DM, Bernardino EMA, Lara B, Lizardo RE, Hawisher D, Bickler S, De Maio A. Isolation and characterization of human urine extracellular vesicles. Cell Stress Chaperones. 2018 May 23. PMID: 29796787.
      View in: PubMed
    3. Arispe N, De Maio A. Memory Loss and the Onset of Alzheimer's Disease Could Be Under the Control of Extracellular Heat Shock Proteins. J Alzheimers Dis. 2018; 63(3):927-934. PMID: 29689729.
      View in: PubMed
    4. Halbach JL, Wang AW, Hawisher D, Cauvi DM, Lizardo RE, Rosas J, Reyes T, Escobedo O, Bickler SW, Coimbra R, De Maio A. Why Antibiotic Treatment Is Not Enough for Sepsis Resolution: an Evaluation in an Experimental Animal Model. Infect Immun. 2017 12; 85(12). PMID: 28947644.
      View in: PubMed
    5. Rivera I, Capone R, Cauvi DM, Arispe N, De Maio A. Modulation of Alzheimer's amyloid ß peptide oligomerization and toxicity by extracellular Hsp70. Cell Stress Chaperones. 2018 Mar; 23(2):269-279. PMID: 28956268.
      View in: PubMed
    6. Bickler SW, Lizardo E, Cauvi DM, De Maio A. The transition from a rural to an urban environment in Africa alters G protein-coupled receptor signaling. Med Hypotheses. 2016 Oct; 95:49-53. PMID: 27692166.
      View in: PubMed
    7. Halbach J, Bickler S, De Maio A. The Molecular Complexity of Sepsis: Expression of Peroxisome Proliferator-Activated Receptor-a, the Tip of the Iceberg? Crit Care Med. 2016 Aug; 44(8):1617-8. PMID: 27428127.
      View in: PubMed
    8. Lopez V, Cauvi DM, Arispe N, De Maio A. Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes. Cell Stress Chaperones. 2016 07; 21(4):609-16. PMID: 27075190; PMCID: PMC4907991 [Available on 01/01/17].
    9. Williams MR, Cauvi DM, Rivera I, Hawisher D, De Maio A. Changes in macrophage function modulated by the lipid environment. Innate Immun. 2016 Apr; 22(3):141-51. PMID: 26951856.
      View in: PubMed
    10. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. PMID: 25513848; PMCID: PMC4524537.
    11. Bickler SW, Lizardo RE, De Maio A. The transition from a rural to an urban environment alters expression of the human Ebola virus receptor Neiman-Pick C1: implications for the current epidemic in West Africa. Cell Stress Chaperones. 2015 Mar; 20(2):203-6. PMID: 25477151; PMCID: PMC4326391.
    12. Vazquez DE, Niño DF, De Maio A, Cauvi DM. Sustained expression of lipocalin-2 during polymicrobial sepsis. Innate Immun. 2015 Jul; 21(5):477-89. PMID: 25227123.
      View in: PubMed
    13. Cauvi DM, Williams MR, Bermudez JA, Armijo G, De Maio A. Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis. Shock. 2014 Sep; 42(3):246-55. PMID: 24978886; PMCID: PMC4134380.
    14. Vega VL, Crotty Alexander LE, Charles W, Hwang JH, Nizet V, De Maio A. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. PMID: 25163764.
      View in: PubMed
    15. Niño DF, Cauvi DM, De Maio A. Itraconazole, a commonly used antifungal, inhibits Fc? receptor-mediated phagocytosis: alteration of Fc? receptor glycosylation and gene expression. Shock. 2014 Jul; 42(1):52-9. PMID: 24667630; PMCID: PMC4071940.
    16. Armijo G, Okerblom J, Cauvi DM, Lopez V, Schlamadinger DE, Kim J, Arispe N, De Maio A. Interaction of heat shock protein 70 with membranes depends on the lipid environment. Cell Stress Chaperones. 2014 Nov; 19(6):877-86. PMID: 24789271; PMCID: PMC4389847.
    17. De Maio A. Extracellular Hsp70: export and function. Curr Protein Pept Sci. 2014 May; 15(3):225-31. PMID: 24694368.
      View in: PubMed
    18. De Maio A. What can we learn from elegant clinical studies?*. Crit Care Med. 2014 Apr; 42(4):972-3. PMID: 24633091; PMCID: PMC3960573.
    19. De Maio A, Vazquez D. Extracellular heat shock proteins: a new location, a new function. Shock. 2013 Oct; 40(4):239-46. PMID: 23807250; PMCID: PMC4351735.
    20. Bickler SW, De Maio A. Dysfunction of the innate immune system during sepsis: a call for research. Crit Care Med. 2013 Jan; 41(1):364-5. PMID: 23269155.
      View in: PubMed
    21. Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012 Aug; 38(3):294-300. PMID: 22683732; PMCID: PMC3422402.
    22. Drummond R, Cauvi DM, Hawisher D, Song D, Niño DF, Coimbra R, Bickler S, De Maio A. Deletion of scavenger receptor A gene in mice resulted in protection from septic shock and modulation of TLR4 signaling in isolated peritoneal macrophages. Innate Immun. 2013 Feb; 19(1):30-41. PMID: 22751446; PMCID: PMC4349423.
    23. Reino DC, Palange D, Feketeova E, Bonitz RP, Xu DZ, Lu Q, Sheth SU, Peña G, Ulloa L, De Maio A, Feinman R, Deitch EA. Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. Shock. 2012 Jul; 38(1):107-14. PMID: 22575992; PMCID: PMC3378823.
    24. Cauvi DM, Song D, Vazquez DE, Hawisher D, Bermudez JA, Williams MR, Bickler S, Coimbra R, De Maio A. Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction. J Biol Chem. 2012 Jun 08; 287(24):19804-15. PMID: 22518839; PMCID: PMC3370166.
    25. De Maio A, Santoro MG, Tanguay RM, Hightower LE. Ferruccio Ritossa's scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal. Cell Stress Chaperones. 2012 Mar; 17(2):139-43. PMID: 22252402; PMCID: PMC3273555.
    26. Bickler SW, Ring J, De Maio A. Sulfur amino acid metabolism limits the growth of children living in environments of poor sanitation. Med Hypotheses. 2011 Sep; 77(3):380-2. PMID: 21658846.
      View in: PubMed
    27. Drummond R, Song D, Hawisher D, Wolf PL, Vazquez DE, Nino DF, Coimbra R, Cauvi DM, De Maio A. Acute acalculous cholecystitis-like phenotype in scavenger receptor A knock-out mice. J Surg Res. 2012 May 15; 174(2):344-51. PMID: 21474146; PMCID: PMC3173564.
    28. De Maio A. Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones. 2011 May; 16(3):235-49. PMID: 20963644; PMCID: PMC3077223.
    29. De Maio A, Tanguay RM, Kampinga H, Lee E, Kim CD, Hightower L. Stress at the Korean Mountains: meeting report of the 8th International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones. 2011 Mar; 16(2):113-8. PMID: 20886326; PMCID: PMC3059799.
    30. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. PMID: 20888586; PMCID: PMC3017641.
    31. Zeidan Q, Wang Z, De Maio A, Hart GW. O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell. 2010 Jun 15; 21(12):1922-36. PMID: 20410138; PMCID: PMC2883937.
    32. Vega VL, Charles W, De Maio A. A new feature of the stress response: increase in endocytosis mediated by Hsp70. Cell Stress Chaperones. 2010 Sep; 15(5):517-27. PMID: 20043217; PMCID: PMC3006637.
    33. Frey T, De Maio A. The antifungal agent itraconazole induces the accumulation of high mannose glycoproteins in macrophages. J Biol Chem. 2009 Jun 19; 284(25):16882-90. PMID: 19414590; PMCID: PMC2719324.
    34. Schilling D, Gehrmann M, Steinem C, De Maio A, Pockley AG, Abend M, Molls M, Multhoff G. Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB J. 2009 Aug; 23(8):2467-77. PMID: 19289606; PMCID: PMC2717766.
    35. Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, De Maio A, Pockley G, Multhoff G. Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. PLoS One. 2008 Apr 02; 3(4):e1925. PMID: 18382692; PMCID: PMC2271151.
    36. Grabowski JE, Vega VL, Talamini MA, De Maio A. Acidification enhances peritoneal macrophage phagocytic activity. J Surg Res. 2008 Jun 15; 147(2):206-11. PMID: 18498871.
      View in: PubMed
    37. Vega VL, Rodríguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhoff G, Arispe N, De Maio A. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol. 2008 Mar 15; 180(6):4299-307. PMID: 18322243.
      View in: PubMed
    38. Frey T, De Maio A. Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin. Mol Med. 2007 Nov-Dec; 13(11-12):592-604. PMID: 17932552; PMCID: PMC2017107.
    39. Hanly EJ, Aurora AA, Shih SP, Fuentes JM, Marohn MR, De Maio A, Talamini MA. Peritoneal acidosis mediates immunoprotection in laparoscopic surgery. Surgery. 2007 Sep; 142(3):357-64. PMID: 17723887.
      View in: PubMed
    40. Fulton WB, Reeves RH, Takeya M, De Maio A. A quantitative trait loci analysis to map genes involved in lipopolysaccharide-induced inflammatory response: identification of macrophage scavenger receptor 1 as a candidate gene. J Immunol. 2006 Mar 15; 176(6):3767-73. PMID: 16517746.
      View in: PubMed
    41. Fuentes JM, Talamini MA, Fulton WB, Hanly EJ, Aurora AR, De Maio A. General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock. Clin Vaccine Immunol. 2006 Feb; 13(2):281-8. PMID: 16467339; PMCID: PMC1391927.
    42. Fuentes JM, Hanly EJ, Aurora AR, De Maio A, Shih SP, Marohn MR, Talamini MA. CO2 abdominal insufflation pretreatment increases survival after a lipopolysaccharide-contaminated laparotomy. J Gastrointest Surg. 2006 Jan; 10(1):32-8. PMID: 16368488.
      View in: PubMed
    43. Balakrishnan K, De Maio A. Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism. Cell Stress Chaperones. 2006; 11(1):44-50. PMID: 16572728; PMCID: PMC1400612.
    44. Multhoff G, De Maio A. Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones. 2006; 11(2):108-15. PMID: 16817316; PMCID: PMC1484512.
    45. Hanly EJ, Aurora AR, Fuentes JM, Shih SP, Marohn MR, De Maio A, Talamini MA. Abdominal insufflation with CO2 causes peritoneal acidosis independent of systemic pH. J Gastrointest Surg. 2005 Dec; 9(9):1245-51; discussion 1251-2. PMID: 16332480.
      View in: PubMed
    46. Alaish SM, Torres M, Ferlito M, Sun CC, De Maio A. The severity of cholestatic injury is modulated by the genetic background. Shock. 2005 Nov; 24(5):412-6. PMID: 16247325.
      View in: PubMed
    47. Vega VL, De Maio A. Increase in phagocytosis after geldanamycin treatment or heat shock: role of heat shock proteins. J Immunol. 2005 Oct 15; 175(8):5280-7. PMID: 16210633.
      View in: PubMed
    48. Fuentes JM, Hanly EJ, Aurora AR, De Maio A, Talamini MA. Anesthesia-specific protection from endotoxic shock is not mediated through the vagus nerve. Surgery. 2005 Oct; 138(4):766-71. PMID: 16269307.
      View in: PubMed
    49. Torres MB, Trentzsch H, Stewart D, Mooney ML, Fuentes JM, Saad DF, Reeves RH, De Maio A. Protection from lethal endotoxic shock after testosterone depletion is linked to chromosome X. Shock. 2005 Oct; 24(4):318-23. PMID: 16205315.
      View in: PubMed
    50. Torres MB, Vega VL, Bedri M, Saad D, Trentzsch H, Reeves RH, De Maio A. IL-10 plasma levels are elevated after LPS injection in splenectomized A/J mice. J Surg Res. 2005 Nov; 129(1):101-6. PMID: 16087192.
      View in: PubMed
    51. Torres MB, De Maio A. An exaggerated inflammatory response after CLP correlates with a negative outcome. J Surg Res. 2005 May 01; 125(1):88-93. PMID: 15836855.
      View in: PubMed
    52. Hanly EJ, Bachman SL, Marohn MR, Boden JH, Herring AE, De Maio A, Talamini MA. Carbon dioxide pneumoperitoneum-mediated attenuation of the inflammatory response is independent of systemic acidosis. Surgery. 2005 May; 137(5):559-66. PMID: 15855930.
      View in: PubMed
    53. Ferlito M, De Maio A. Enhanced LPS-induced TNF alpha production in heat-shocked human promonocytic cells: regulation at the translational/post-translational level. Biochim Biophys Acta. 2005 Mar 22; 1743(1-2):20-8. PMID: 15777836.
      View in: PubMed
    54. De Maio A, Torres MB, Reeves RH. Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock. 2005 Jan; 23(1):11-7. PMID: 15614125.
      View in: PubMed
    55. Arispe N, Doh M, Simakova O, Kurganov B, De Maio A. Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability. FASEB J. 2004 Nov; 18(14):1636-45. PMID: 15522909.
      View in: PubMed
    56. Vega VL, De Cabo R, De Maio A. Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice. Shock. 2004 Sep; 22(3):248-53. PMID: 15316395.
      View in: PubMed
    57. Morrison WE, Arbelaez JJ, Fackler JC, De Maio A, Paidas CN. Gender and age effects on outcome after pediatric traumatic brain injury. Pediatr Crit Care Med. 2004 Mar; 5(2):145-51. PMID: 14987344.
      View in: PubMed
    58. Cornivelli L, Zeidan Q, De Maio A. HSP70 interacts with ribosomal subunits of thermotolerant cells. Shock. 2003 Oct; 20(4):320-5. PMID: 14501945.
      View in: PubMed
    59. Trentzsch H, Stewart D, Paidas CN, De Maio A. The combination of polymicrobial sepsis and endotoxin results in an inflammatory process that could not be predicted from the independent insults. J Surg Res. 2003 May 15; 111(2):203-8. PMID: 12850463.
      View in: PubMed
    60. Hanly EJ, Mendoza-Sagaon M, Murata K, Hardacre JM, De Maio A, Talamini MA. CO2 Pneumoperitoneum modifies the inflammatory response to sepsis. Ann Surg. 2003 Mar; 237(3):343-50. PMID: 12616117; PMCID: PMC1514307.
    61. Vega VL, De Maio A. Geldanamycin treatment ameliorates the response to LPS in murine macrophages by decreasing CD14 surface expression. Mol Biol Cell. 2003 Feb; 14(2):764-73. PMID: 12589068; PMCID: PMC150006.
    62. Trentzsch H, Stewart D, De Maio A. Genetic background conditions the effect of sex steroids on the inflammatory response during endotoxic shock. Crit Care Med. 2003 Jan; 31(1):232-6. PMID: 12545021.
      View in: PubMed
    63. Arispe N, Doh M, De Maio A. Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70. Cell Stress Chaperones. 2002 Oct; 7(4):330-8. PMID: 12653477; PMCID: PMC514832.
    64. Stewart D, Fulton WB, Wilson C, Monitto CL, Paidas CN, Reeves RH, De Maio A. Genetic contribution to the septic response in a mouse model. Shock. 2002 Oct; 18(4):342-7. PMID: 12392278.
      View in: PubMed
    65. De Maio A, Vega VL, Contreras JE. Gap junctions, homeostasis, and injury. J Cell Physiol. 2002 Jun; 191(3):269-82. PMID: 12012322.
      View in: PubMed
    66. Paidas CN, Mooney ML, Theodorakis NG, De Maio A. Accelerated recovery after endotoxic challenge in heat shock-pretreated mice. Am J Physiol Regul Integr Comp Physiol. 2002 May; 282(5):R1374-81. PMID: 11959679.
      View in: PubMed