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Antonio De Maio

Title(s)Professor, Surgery
SchoolHealth Sciences
Phone858-822-6501
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    Collapse Overview 
    Collapse Overview
    Dr. Antonio De Maio is professor and a member of the Biomedical Sciences Graduate Program (BMS) at UC San Diego.

    A graduate of the Central University of Venezuela in Caracas, Dr. Antonio De Maio received his PhD from the Weizmann Institute of Science in Rehovot, Israel. Dr. Antonio De Maio joined the faculty at UC San Diego School of Medicine in January 2006.

    Prior to that, he was an Associate Professor and Research Director for the Division of Pediatric Surgery at Johns Hopkins University. While at Hopkins, Dr. De Maio led the Committee for the Recruitment of Under-represented Minorities to Graduate Programs and the Post-baccalaureate Research Education Program (PREP). At UC San Diego, Dr. De Maio continues to be very active in increasing student diversity in graduate and medical school.

    He received a Vice Chancellor of Health Sciences 2007 Equal Opportunity/Affirmative Action and Diversity Award. Dr. De Maio is the Director of the Initiative to Maximize Student Diversity (IMSD) Program at UC San Diego, which is supported by NIGMS-NIH.

    Dr. De Maio is a member of the American Association for the Advancement of Science (AAAS), American Society for Cell Biology (ASCB), American Association of Immunologist (AAI), Cell Stress Society International (President-Elect), International Endotoxin Society (IEIIS), PanAmerican Trauma Society, Shock Society, Society of Critical Care Medicine (SCCM), and Society for Advancement of Chicanos and Native Americans in Science (SACNAS).

    The Antonio De Maio Laboratory
    Located on UC San Diego's beautiful La Jolla campus, the Antonio De Maio laboratory is investigating the molecular and genetic bases of the response to injury. Traumatic injury is a major cause of mortality and morbidity in the United States, particularly among children.

    The Antonio De Maio laboratory has found that the response to injury is modulated by several confounding factors including genetic background, sex, age, diet, and environment. The major factor associated with morbidity and mortality injury is an overwhelming inflammatory response.

    The Antonio De Maio group is using mouse genetics to identify genes that regulate the inflammatory process as potential therapeutic targets. In addition, the Antonio De Maio laboratory is studying the role of heat shock proteins in the regulation of the inflammatory response.

    The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels.

    The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels. For more information on their research, please click here.

    Collapse Research 
    Collapse Research Activities and Funding
    Contribution of Cholesterol Homeostasis for Injury Resolution
    NIH/NIGMS R01GM114473Apr 1, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Heat Shock Proteins and the Stress Observation System
    NIH/NIGMS R01GM098455Sep 1, 2012 - Apr 30, 2016
    Role: Principal Investigator
    UCSD MARC Program
    NIH/NIGMS T34GM087193Jun 1, 2009 - May 31, 2015
    Role: Principal Investigator
    Mentoring Young Minds to Increase Diversity in the Biomedical Research
    NIH/NIGMS R25GM083275Mar 1, 2008 - Jan 31, 2023
    Role: Principal Investigator
    Modifier genes of sepsis
    NIH/NIGMS R01GM073825Sep 1, 2006 - Aug 31, 2011
    Role: Principal Investigator
    GENETIC CONTRIBUTION TO THE STRESS RESPONSE
    NIH/NIGMS R01GM057317Jan 1, 1999 - Dec 31, 2004
    Role: Principal Investigator
    Mechanisms of cytoprotection induced by stress proteins
    NIH/NIGMS R01GM050878Aug 1, 1994 - Jul 31, 2010
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. De Maio A, Cauvi DM, Capone R, Bello I, Egberts WV, Arispe N, Boelens W. The small heat shock proteins, HSPB1 and HSPB5, interact differently with lipid membranes. Cell Stress Chaperones. 2019 Jul 23. PMID: 31338686.
      View in: PubMed
    2. De Maio A. Reply to "Bacterial Proliferation May Be the Key Component of Sepsis Mortality". Infect Immun. 2018 Nov; 86(11). PMID: 30361456.
      View in: PubMed
    3. De Maio A. Extracellular Hsp70: export and function. Curr Protein Pept Sci. 2014 May; 15(3):225-31. PMID: 24694368.
      View in: PubMed
    4. De Maio A, Santoro MG, Tanguay RM, Hightower LE. Ferruccio Ritossa's scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal. Cell Stress Chaperones. 2012 Mar; 17(2):139-43. PMID: 22252402; PMCID: PMC3273555.
    5. De Maio A. Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones. 2011 May; 16(3):235-49. PMID: 20963644; PMCID: PMC3077223.
    6. Bickler SW, DeMaio A. Western diseases: current concepts and implications for pediatric surgery research and practice. Pediatr Surg Int. 2008 Mar; 24(3):251-5. PMID: 18087704.
      View in: PubMed
    7. Gross C, Koelch W, DeMaio A, Arispe N, Multhoff G. Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem. 2003 Oct 17; 278(42):41173-81. PMID: 12874291.
      View in: PubMed
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