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Anne Murphy

Title(s)Adjunct Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0636
La Jolla CA 92093
Phone858-246-0573
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    Collapse Biography 
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    George Washington UniversityPh.D.School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic role of the neuronal Na+-dependent citrate transporter implicated in epilepsy
    NIH/NINDS R21NS104513May 15, 2018 - Apr 30, 2020
    Role: Co-Principal Investigator
    Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease
    NIH/NINDS R01NS087611May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    PPAR-sparing/free Thiazolidinediones for Treatment of Diabetes
    NIH/NIDDK R42DK081298May 1, 2009 - Nov 30, 2009
    Role: Principal Investigator
    OSTEOARTHRITIS/CHONDROCALCINOSIS: MITOCHONDRIAL THERAPY
    NIH/NIAMS R43AR049145Sep 24, 2003 - May 31, 2004
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH/NIDDK P01DK054441Dec 15, 1998 - Nov 30, 2001
    Role: Co-Investigator
    BC1-2 IN HYPOXIA/REOXYGENATION
    NIH/NINDS R01NS034154Aug 10, 1996 - Apr 30, 2000
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sub-nanowatt microfluidic single-cell calorimetry. Nat Commun. 2020 Jun 12; 11(1):2982. Hong S, Dechaumphai E, Green CR, Lal R, Murphy AN, Metallo CM, Chen R. PMID: 32532969.
      View in: PubMed   Mentions:    Fields:    
    2. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 May 20; e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AM, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379.
      View in: PubMed   Mentions:    Fields:    
    3. Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):328-336. Liu X, Xiao W, Zhang Y, Wiley SE, Zuo T, Zheng Y, Chen N, Chen L, Wang X, Zheng Y, Huang L, Lin S, Murphy AN, Dixon JE, Xu P, Guo X. PMID: 31843888.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. Mol Metab. 2020 02; 32:122-135. Cordes T, Lucas A, Divakaruni AS, Murphy AN, Cabrales P, Metallo CM. PMID: 32029222.
      View in: PubMed   Mentions:    Fields:    
    5. Do Two Mitochondrial Wrongs Help Make Cells Right? Trends Mol Med. 2020 Jan; 26(1):3-6. Divakaruni AS, Murphy AN. PMID: 31813762.
      View in: PubMed   Mentions:    Fields:    
    6. Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells. Cancer Res. 2019 09 01; 79(17):4360-4370. Wu X, Yeerna H, Goto Y, Ando T, Wu VH, Zhang X, Wang Z, Amornphimoltham P, Murphy AN, Tamayo P, Chen Q, Lippman SM, Gutkind JS. PMID: 31292160.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia. Neurobiol Dis. 2019 10; 130:104502. Swinton MK, Carson A, Telese F, Sanchez AB, Soontornniyomkij B, Rad L, Batki I, Quintanilla B, Pérez-Santiago J, Achim CL, Letendre S, Ellis RJ, Grant I, Murphy AN, Fields JA. PMID: 31238091.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. JCI Insight. 2019 04 16; 5. Woodall BP, Orogo AM, Najor RH, Cortez MQ, Moreno ER, Wang H, Divakaruni AS, Murphy AN, Gustafsson ÅB. PMID: 30990467.
      View in: PubMed   Mentions: 2     Fields:    
    9. Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734.
      View in: PubMed   Mentions: 9     Fields:    
    10. Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer. J Vis Exp. 2019 02 13; (144). Tachibana S, Chen C, Zhang OR, Schurr SV, Hill C, Li R, Manso AM, Zhang J, Andreyev A, Murphy AN, Ross RS, Cho Y. PMID: 30829322.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019 Jan; 1(1):86-97. Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM. PMID: 31528845.
      View in: PubMed   Mentions:
    13. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 11; 77(11):1636-1643. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. PMID: 30061164.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. PMID: 30105314.
      View in: PubMed   Mentions:
    15. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 09 04; 28(3):504-515.e7. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. PMID: 30043753.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis. Arthritis Rheumatol. 2018 07; 70(7):984-999. Falconer J, Murphy AN, Young SP, Clark AR, Tiziani S, Guma M, Buckley CD. PMID: 29579371.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018 03; 25(3):542-572. Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. PMID: 29229998.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents. Anal Biochem. 2018 07 01; 552:60-65. Divakaruni AS, Andreyev AY, Rogers GW, Murphy AN. PMID: 28987935.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and reduces survival. J Biol Chem. 2017 07 07; 292(27):11348. Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB. PMID: 28687597.
      View in: PubMed   Mentions:    Fields:    
    21. Impaired mitophagy facilitates mitochondrial damage in Danon disease. J Mol Cell Cardiol. 2017 07; 108:86-94. Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED. PMID: 28526246.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. PMID: 28254829.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    23. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017 09; 43(Pt B):208-217. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. PMID: 28034771.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 08 09; 16(6):1536-1547. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM. PMID: 27477285.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. PMID: 26815411.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 01; 291(27):14274-84. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. PMID: 27189937.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    27. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016 Mar 02; 6:22538. Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV. PMID: 26932729.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. PMID: 26611103.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    29. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM. PMID: 26571352.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    30. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes. 2015 Sep; 64(9):3273-84. Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M. PMID: 26294429.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    31. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival. J Biol Chem. 2015 Sep 04; 290(36):22061-75. Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB. PMID: 26183775.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Mitochondrial ROS Metabolism: 10 Years Later. Biochemistry (Mosc). 2015 May; 80(5):517-31. Andreyev AY, Kushnareva YE, Murphy AN, Starkov AA. PMID: 26071769.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    34. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress. Free Radic Biol Med. 2015 May; 82:63-72. Andreyev AY, Tsui HS, Milne GL, Shmanai VV, Bekish AV, Fomich MA, Pham MN, Nong Y, Murphy AN, Clarke CF, Shchepinov MS. PMID: 25578654.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    36. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 06; 56(3):425-35. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM. PMID: 25458843.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    37. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. PMID: 25159328.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode. Curr Protoc Toxicol. 2014 May 27; 60:25.2.1-16. Divakaruni AS, Rogers GW, Murphy AN. PMID: 24865646.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    39. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. PMID: 24908200.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    40. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM. PMID: 24755473.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    41. A new non-canonical pathway of Ga(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal. 2014 May; 26(5):1135-46. Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown JH, Murphy AN, Zorzano A, Enríquez JA, Aragay AM. PMID: 24444709.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. Analysis and interpretation of microplate-based oxygen consumption and pH data. Methods Enzymol. 2014; 547:309-54. Divakaruni AS, Paradyse A, Ferrick DA, Murphy AN, Jastroch M. PMID: 25416364.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    43. Methods in Enzymology. Mitochondrial function. Preface. Methods Enzymol. 2014; 547:xix-xx. Murphy AN, Chan DC. PMID: 25416370.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    44. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. PMID: 23703906.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    45. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8(5):e61551. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. PMID: 23690925.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    46. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5422-7. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN. PMID: 23513224.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    47. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem. 2013 Jan 11; 288(2):915-26. Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, Jimenez R, Petrosyan S, Murphy AN, Gustafsson AB. PMID: 23152496.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    48. Stroke outcome in the ketogenic state--a systematic review of the animal data. J Neurochem. 2012 Nov; 123 Suppl 2:52-7. Gibson CL, Murphy AN, Murphy SP. PMID: 23050642.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    49. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. Darshi M, Trinh KN, Murphy AN, Taylor SS. PMID: 23019327.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    50. Isozyme-specific interaction of protein kinase Cd with mitochondria dissected using live cell fluorescence imaging. J Biol Chem. 2012 Nov 02; 287(45):37891-906. Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. PMID: 22988234.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    51. Cell biology. A mitochondrial mystery, solved. Science. 2012 Jul 06; 337(6090):41-3. Divakaruni AS, Murphy AN. PMID: 22767917.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    52. Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 02; 15(5):778-86. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. PMID: 22560226.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    53. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):E1227-35. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. PMID: 22084075.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    54. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 22376256.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    55. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. PMID: 21862885.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    56. High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One. 2011; 6(7):e21746. Rogers GW, Brand MD, Petrosyan S, Ashok D, Elorza AA, Ferrick DA, Murphy AN. PMID: 21799747.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    57. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-70. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. PMID: 21757760.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    58. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. PMID: 21641550.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    59. Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ. 2011 Apr; 18(4):721-31. Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, Gustafsson ÅB. PMID: 21278801.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    60. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS. PMID: 21081504.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    61. Pre-clinical systematic review. J Neurochem. 2010 Nov; 115(4):805. Murphy SP, Murphy AN. PMID: 21038509.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    62. Administration of thiazolidinediones for neuroprotection in ischemic stroke: a pre-clinical systematic review. J Neurochem. 2010 Nov; 115(4):845-53. White AT, Murphy AN. PMID: 20964688.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    63. Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes. 2009 Nov; 58(11):2476-85. Yeh TY, Beiswenger KK, Li P, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW. PMID: 19651815.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease. EMBO Mol Med. 2009 May; 1(2):81-4. Murphy AN. PMID: 20049706.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    65. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. Miyamoto S, Murphy AN, Brown JH. PMID: 19377835.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    66. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15; 389(2):157-64. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE. PMID: 19341700.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    67. Mitochondrial function, part B: mitochondrial protein kinases, protein phosphatases and mitochondrial diseases. Preface. Methods Enzymol. 2009; 457:xxv-xxvi. Murphy AN, Allison WS. PMID: 19426858.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    68. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. J Biol Chem. 2009 Feb 20; 284(8):5414-24. Tang T, Zheng B, Chen SH, Murphy AN, Kudlicka K, Zhou H, Farquhar MG. PMID: 19103604.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    69. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008 May 30; 283(22):15440-50. Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE. PMID: 18385140.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    70. Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. Cell Death Differ. 2008 Mar; 15(3):521-9. Miyamoto S, Murphy AN, Brown JH. PMID: 18064042.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    71. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14342-7. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA. PMID: 17766440.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    72. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem. 2007 Aug 17; 282(33):23745-9. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE. PMID: 17584744.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    73. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5318-23. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. PMID: 17376863.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    74. Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity. Cell Death Differ. 2007 Mar; 14(3):616-24. Yamaguchi R, Andreyev A, Murphy AN, Perkins GA, Ellisman MH, Newmeyer DD. PMID: 16977331.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    75. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 09; 280(49):40398-401. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. PMID: 16207717.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    76. Excitotoxic injury to mitochondria isolated from cultured neurons. J Biol Chem. 2005 Aug 12; 280(32):28894-902. Kushnareva YE, Wiley SE, Ward MW, Andreyev AY, Murphy AN. PMID: 15932874.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    77. Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum. 2004 Apr; 50(4):1216-25. Johnson K, Svensson CI, Etten DV, Ghosh SS, Murphy AN, Powell HC, Terkeltaub R. PMID: 15077304.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    78. Characterization of the human heart mitochondrial proteome. Nat Biotechnol. 2003 Mar; 21(3):281-6. Taylor SW, Fahy E, Zhang B, Glenn GM, Warnock DE, Wiley S, Murphy AN, Gaucher SP, Capaldi RA, Gibson BW, Ghosh SS. PMID: 12592411.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    79. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J. 2002 Dec 01; 368(Pt 2):545-53. Kushnareva Y, Murphy AN, Andreyev A. PMID: 12180906.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    80. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab. 1999 Apr; 19(4):351-69. Fiskum G, Murphy AN, Beal MF. PMID: 10197505.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    81. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem. 1996 Sep; 67(3):1259-67. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE. PMID: 8752134.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    82. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem. 1995 Dec; 65(6):2432-40. Myers KM, Fiskum G, Liu Y, Simmens SJ, Bredesen DE, Murphy AN. PMID: 7595537.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    83. Submicromolar Ca2+ regulates phosphorylating respiration by normal rat liver and AS-30D hepatoma mitochondria by different mechanisms. J Biol Chem. 1990 Jun 25; 265(18):10527-34. Murphy AN, Kelleher JK, Fiskum G. PMID: 2113059.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    84. Analysis of tricarboxylic acid-cycle metabolism of hepatoma cells by comparison of 14CO2 ratios. Biochem J. 1987 Sep 15; 246(3):633-9. Kelleher JK, Bryan BM, Mallet RT, Holleran AL, Murphy AN, Fiskum G. PMID: 3120698.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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