Loading...

Anne Murphy

Title(s)Adjunct Professor, Pharmacology
SchoolHealth Sciences
Phone858-246-0573
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    George Washington UniversityPh.D.School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic role of the neuronal Na+-dependent citrate transporter implicated in epilepsy
    NIH/NINDS R21NS104513May 15, 2018 - Apr 30, 2020
    Role: Co-Principal Investigator
    Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease
    NIH/NINDS R01NS087611May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    PPAR-sparing/free Thiazolidinediones for Treatment of Diabetes
    NIH/NIDDK R42DK081298May 1, 2009 - Mar 31, 2012
    Role: Principal Investigator
    OSTEOARTHRITIS/CHONDROCALCINOSIS: MITOCHONDRIAL THERAPY
    NIH/NIAMS R43AR049145Sep 24, 2003 - May 31, 2004
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
    Role: Co-Investigator
    BC1-2 IN HYPOXIA/REOXYGENATION
    NIH/NINDS R01NS034154Aug 10, 1996 - Apr 30, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Swinton MK, Carson A, Telese F, Sanchez AB, Soontornniyomkij B, Rad L, Batki I, Quintanilla B, Pérez-Santiago J, Achim CL, Letendre S, Ellis RJ, Grant I, Murphy AN, Fields JA. Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia. Neurobiol Dis. 2019 Jun 22; 130:104502. PMID: 31238091.
      View in: PubMed
    2. Woodall BP, Orogo AM, Najor RH, Cortez MQ, Moreno ER, Wang H, Divakaruni AS, Murphy AN, Gustafsson ÅB. Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. JCI Insight. 2019 Apr 16; 5. PMID: 30990467.
      View in: PubMed
    3. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production. Cell Metab. 2019 Jun 04; 29(6):1350-1362.e7. PMID: 30982734.
      View in: PubMed
    4. Tachibana S, Chen C, Zhang OR, Schurr SV, Hill C, Li R, Manso AM, Zhang J, Andreyev A, Murphy AN, Ross RS, Cho Y. Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer. J Vis Exp. 2019 Feb 13; (144). PMID: 30829322.
      View in: PubMed
    5. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 Dec 04; 25(10):2904-2918.e8. PMID: 30517875.
      View in: PubMed
    6. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 Nov; 77(11):1636-1643. PMID: 30061164.
      View in: PubMed
    7. Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). PMID: 30105314.
      View in: PubMed
    8. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 Sep 04; 28(3):504-515.e7. PMID: 30043753.
      View in: PubMed
    9. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 Sep 04; 28(3):490-503.e7. PMID: 30043752.
      View in: PubMed
    10. Falconer J, Murphy AN, Young SP, Clark AR, Tiziani S, Guma M, Buckley CD. Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis. Arthritis Rheumatol. 2018 Jul; 70(7):984-999. PMID: 29579371.
      View in: PubMed
    11. Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018 Mar; 25(3):542-572. PMID: 29229998.
      View in: PubMed
    12. Barros LF, Bolaños JP, Bonvento G, Bouzier-Sore AK, Brown A, Hirrlinger J, Kasparov S, Kirchhoff F, Murphy AN, Pellerin L, Robinson MB, Weber B. Current technical approaches to brain energy metabolism. Glia. 2018 06; 66(6):1138-1159. PMID: 29110344.
      View in: PubMed
    13. Divakaruni AS, Andreyev AY, Rogers GW, Murphy AN. In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents. Anal Biochem. 2018 Jul 01; 552:60-65. PMID: 28987935.
      View in: PubMed
    14. Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB. Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and reduces survival. J Biol Chem. 2017 07 07; 292(27):11348. PMID: 28687597.
      View in: PubMed
    15. Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED. Impaired mitophagy facilitates mitochondrial damage in Danon disease. J Mol Cell Cardiol. 2017 07; 108:86-94. PMID: 28526246.
      View in: PubMed
    16. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. PMID: 28254829.
      View in: PubMed
    17. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017 09; 43(Pt B):208-217. PMID: 28034771.
      View in: PubMed
    18. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 08 09; 16(6):1536-1547. PMID: 27477285; PMCID: PMC4981511.
      View in: PubMed, PubMed Central
    19. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. PMID: 26815411; PMCID: PMC4963240.
      View in: PubMed, PubMed Central
    20. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 01; 291(27):14274-84. PMID: 27189937; PMCID: PMC4933182 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    21. Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016 Mar 02; 6:22538. PMID: 26932729; PMCID: PMC4773760.
      View in: PubMed, PubMed Central
    22. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. PMID: 26611103; PMCID: PMC4713337.
      View in: PubMed, PubMed Central
    23. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. PMID: 26571352; PMCID: PMC4684771.
      View in: PubMed, PubMed Central
    24. Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes. 2015 Sep; 64(9):3273-84. PMID: 26294429; PMCID: PMC4542449.
      View in: PubMed, PubMed Central
    25. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
      View in: PubMed, PubMed Central
    26. Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB. Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival. J Biol Chem. 2015 Sep 04; 290(36):22061-75. PMID: 26183775; PMCID: PMC4571958.
      View in: PubMed, PubMed Central
    27. Andreyev AY, Kushnareva YE, Murphy AN, Starkov AA. Mitochondrial ROS Metabolism: 10 Years Later. Biochemistry (Mosc). 2015 May; 80(5):517-31. PMID: 26071769.
      View in: PubMed
    28. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. PMID: 25605649; PMCID: PMC4344921.
      View in: PubMed, PubMed Central
    29. Andreyev AY, Tsui HS, Milne GL, Shmanai VV, Bekish AV, Fomich MA, Pham MN, Nong Y, Murphy AN, Clarke CF, Shchepinov MS. Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress. Free Radic Biol Med. 2015 May; 82:63-72. PMID: 25578654.
      View in: PubMed
    30. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 06; 56(3):425-35. PMID: 25458843; PMCID: PMC4267523.
      View in: PubMed, PubMed Central
    31. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. PMID: 25159328; PMCID: PMC4216952.
      View in: PubMed, PubMed Central
    32. Divakaruni AS, Rogers GW, Murphy AN. Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode. Curr Protoc Toxicol. 2014 May 27; 60:25.2.1-16. PMID: 24865646.
      View in: PubMed
    33. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. PMID: 24908200; PMCID: PMC4506135.
      View in: PubMed, PubMed Central
    34. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. PMID: 24755473; PMCID: PMC4885639.
      View in: PubMed, PubMed Central
    35. Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown JH, Murphy AN, Zorzano A, Enríquez JA, Aragay AM. A new non-canonical pathway of Ga(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal. 2014 May; 26(5):1135-46. PMID: 24444709; PMCID: PMC4745894.
      View in: PubMed, PubMed Central
    36. Divakaruni AS, Paradyse A, Ferrick DA, Murphy AN, Jastroch M. Analysis and interpretation of microplate-based oxygen consumption and pH data. Methods Enzymol. 2014; 547:309-54. PMID: 25416364.
      View in: PubMed
    37. Murphy AN, Chan DC. Methods in Enzymology. Mitochondrial function. Preface. Methods Enzymol. 2014; 547:xix-xx. PMID: 25416370.
      View in: PubMed
    38. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. PMID: 23703906; PMCID: PMC3779451.
      View in: PubMed, PubMed Central
    39. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8(5):e61551. PMID: 23690925.
      View in: PubMed
    40. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5422-7. PMID: 23513224; PMCID: PMC3619368.
      View in: PubMed, PubMed Central
    41. Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, Jimenez R, Petrosyan S, Murphy AN, Gustafsson AB. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem. 2013 Jan 11; 288(2):915-26. PMID: 23152496; PMCID: PMC3543040.
      View in: PubMed, PubMed Central
    42. Gibson CL, Murphy AN, Murphy SP. Stroke outcome in the ketogenic state--a systematic review of the animal data. J Neurochem. 2012 Nov; 123 Suppl 2:52-7. PMID: 23050642; PMCID: PMC3970216.
      View in: PubMed, PubMed Central
    43. Darshi M, Trinh KN, Murphy AN, Taylor SS. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. PMID: 23019327; PMCID: PMC3501047.
      View in: PubMed, PubMed Central
    44. Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. Isozyme-specific interaction of protein kinase Cd with mitochondria dissected using live cell fluorescence imaging. J Biol Chem. 2012 Nov 02; 287(45):37891-906. PMID: 22988234; PMCID: PMC3488061.
      View in: PubMed, PubMed Central
    45. Divakaruni AS, Murphy AN. Cell biology. A mitochondrial mystery, solved. Science. 2012 Jul 06; 337(6090):41-3. PMID: 22767917.
      View in: PubMed
    46. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 02; 15(5):778-86. PMID: 22560226.
      View in: PubMed
    47. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):E1227-35. PMID: 22084075; PMCID: PMC3228425.
      View in: PubMed, PubMed Central
    48. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. PMID: 22376256.
      View in: PubMed
    49. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. PMID: 21862885; PMCID: PMC3162469.
      View in: PubMed, PubMed Central
    50. Rogers GW, Brand MD, Petrosyan S, Ashok D, Elorza AA, Ferrick DA, Murphy AN. High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One. 2011; 6(7):e21746. PMID: 21799747; PMCID: PMC3143121.
      View in: PubMed, PubMed Central
    51. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-70. PMID: 21757760; PMCID: PMC3162416.
      View in: PubMed, PubMed Central
    52. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. PMID: 21641550; PMCID: PMC3119201.
      View in: PubMed, PubMed Central
    53. Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, Gustafsson ÅB. Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ. 2011 Apr; 18(4):721-31. PMID: 21278801.
      View in: PubMed
    54. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. PMID: 21081504.
      View in: PubMed
    55. Murphy SP, Murphy AN. Pre-clinical systematic review. J Neurochem. 2010 Nov; 115(4):805. PMID: 21038509.
      View in: PubMed
    56. White AT, Murphy AN. Administration of thiazolidinediones for neuroprotection in ischemic stroke: a pre-clinical systematic review. J Neurochem. 2010 Nov; 115(4):845-53. PMID: 20964688; PMCID: PMC2981074.
      View in: PubMed, PubMed Central
    57. Yeh TY, Beiswenger KK, Li P, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW. Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes. 2009 Nov; 58(11):2476-85. PMID: 19651815; PMCID: PMC2768175.
      View in: PubMed, PubMed Central
    58. Murphy AN. In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease. EMBO Mol Med. 2009 May; 1(2):81-4. PMID: 20049706; PMCID: PMC3378120.
      View in: PubMed, PubMed Central
    59. Miyamoto S, Murphy AN, Brown JH. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. PMID: 19377835; PMCID: PMC2732429.
      View in: PubMed, PubMed Central
    60. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15; 389(2):157-64. PMID: 19341700; PMCID: PMC2713743.
      View in: PubMed, PubMed Central
    61. Murphy AN, Allison WS. Mitochondrial function, part B: mitochondrial protein kinases, protein phosphatases and mitochondrial diseases. Preface. Methods Enzymol. 2009; 457:xxv-xxvi. PMID: 19426858.
      View in: PubMed
    62. Tang T, Zheng B, Chen SH, Murphy AN, Kudlicka K, Zhou H, Farquhar MG. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. J Biol Chem. 2009 Feb 20; 284(8):5414-24. PMID: 19103604; PMCID: PMC2643507.
      View in: PubMed, PubMed Central
    63. Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008 May 30; 283(22):15440-50. PMID: 18385140; PMCID: PMC2397459.
      View in: PubMed, PubMed Central
    64. Miyamoto S, Murphy AN, Brown JH. Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. Cell Death Differ. 2008 Mar; 15(3):521-9. PMID: 18064042.
      View in: PubMed
    65. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14342-7. PMID: 17766440; PMCID: PMC1963346.
      View in: PubMed, PubMed Central
    66. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem. 2007 Aug 17; 282(33):23745-9. PMID: 17584744.
      View in: PubMed
    67. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5318-23. PMID: 17376863; PMCID: PMC1838440.
      View in: PubMed, PubMed Central
    68. Yamaguchi R, Andreyev A, Murphy AN, Perkins GA, Ellisman MH, Newmeyer DD. Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity. Cell Death Differ. 2007 Mar; 14(3):616-24. PMID: 16977331.
      View in: PubMed
    69. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 09; 280(49):40398-401. PMID: 16207717; PMCID: PMC2612541.
      View in: PubMed, PubMed Central
    70. Kushnareva YE, Wiley SE, Ward MW, Andreyev AY, Murphy AN. Excitotoxic injury to mitochondria isolated from cultured neurons. J Biol Chem. 2005 Aug 12; 280(32):28894-902. PMID: 15932874.
      View in: PubMed
    71. Johnson K, Svensson CI, Etten DV, Ghosh SS, Murphy AN, Powell HC, Terkeltaub R. Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum. 2004 Apr; 50(4):1216-25. PMID: 15077304.
      View in: PubMed
    72. Taylor SW, Fahy E, Zhang B, Glenn GM, Warnock DE, Wiley S, Murphy AN, Gaucher SP, Capaldi RA, Gibson BW, Ghosh SS. Characterization of the human heart mitochondrial proteome. Nat Biotechnol. 2003 Mar; 21(3):281-6. PMID: 12592411.
      View in: PubMed
    73. Kushnareva Y, Murphy AN, Andreyev A. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J. 2002 Dec 01; 368(Pt 2):545-53. PMID: 12180906; PMCID: PMC1222999.
      View in: PubMed, PubMed Central
    74. Fiskum G, Murphy AN, Beal MF. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab. 1999 Apr; 19(4):351-69. PMID: 10197505.
      View in: PubMed
    75. Murphy AN, Fiskum G, Beal MF. Mitochondria in neurodegeneration: bioenergetic function in cell life and death. J Cereb Blood Flow Metab. 1999 Mar; 19(3):231-45. PMID: 10078875.
      View in: PubMed
    76. Murphy AN. Ca(2+)-mediated mitochondrial dysfunction and the protective effects of Bcl-2. Ann N Y Acad Sci. 1999; 893:19-32. PMID: 10672227.
      View in: PubMed
    77. Murphy AN, Fiskum G. Bcl-2 and Ca(2+)-mediated mitochondrial dysfunction in neural cell death. Biochem Soc Symp. 1999; 66:33-41. PMID: 10989655.
      View in: PubMed
    78. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9893-8. PMID: 8790427.
      View in: PubMed
    79. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem. 1996 Sep; 67(3):1259-67. PMID: 8752134.
      View in: PubMed
    80. Myers KM, Fiskum G, Liu Y, Simmens SJ, Bredesen DE, Murphy AN. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem. 1995 Dec; 65(6):2432-40. PMID: 7595537.
      View in: PubMed
    81. Murphy AN, Kelleher JK, Fiskum G. Submicromolar Ca2+ regulates phosphorylating respiration by normal rat liver and AS-30D hepatoma mitochondria by different mechanisms. J Biol Chem. 1990 Jun 25; 265(18):10527-34. PMID: 2113059.
      View in: PubMed
    82. Murphy AN, Kelleher JK, Fiskum G. Calcium sensitive isocitrate and 2-oxoglutarate dehydrogenase activities in rat liver and AS-30D hepatoma mitochondria. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1218-25. PMID: 3207422.
      View in: PubMed
    83. Murphy AN, Fiskum G. Ca2+-transport-mediated regulation of metabolism in hepatoma mitochondria. Ann N Y Acad Sci. 1988; 551:253-5. PMID: 3245663.
      View in: PubMed
    84. Murphy AN, Fiskum G. Abnormal Ca2+ transport characteristics of hepatoma mitochondria and endoplasmic reticulum. Adv Exp Med Biol. 1988; 232:139-50. PMID: 3213683.
      View in: PubMed
    85. Kelleher JK, Bryan BM, Mallet RT, Holleran AL, Murphy AN, Fiskum G. Analysis of tricarboxylic acid-cycle metabolism of hepatoma cells by comparison of 14CO2 ratios. Biochem J. 1987 Sep 15; 246(3):633-9. PMID: 3120698.
      View in: PubMed
    Anne's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (463) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (77) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑