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Anna Devor

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0624
La Jolla CA 92093
Phone858-232-9940
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    Collapse Research 
    Collapse Research Activities and Funding
    Microscopic foundation of multimodal human imaging
    NIH/NIMH R01MH111359Sep 15, 2016 - May 31, 2021
    Role: Principal Investigator
    Non-degenerate multiphoton microscopy for deep brain imaging
    NIH/NINDS U01NS094232Sep 30, 2015 - Jun 30, 2018
    Role: Principal Investigator
    In vivo 2-photon imaging of NADH in health and disease
    NIH/NIBIB R21EB012620Jan 15, 2011 - Dec 31, 2013
    Role: Principal Investigator
    Two-photon Calcium Imaging of Specific Neuronal Phenotypes
    NIH/NIBIB R21EB009118Jun 1, 2009 - May 31, 2011
    Role: Principal Investigator
    Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopy
    NIH/NINDS R01NS057198Dec 1, 2006 - May 31, 2018
    Role: Principal Investigator
    Neurovascular Coupling in Cerebrum and Cerebellum
    NIH/NINDS R01NS051188May 23, 2005 - Jun 30, 2010
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Thunemann M, Lu Y, Liu X, Kiliç K, Desjardins M, Vandenberghe M, Sadegh S, Saisan PA, Cheng Q, Weldy KL, Lyu H, Djurovic S, Andreassen OA, Dale AM, Devor A, Kuzum D. Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays. Nat Commun. 2018 May 23; 9(1):2035. PMID: 29789548.
      View in: PubMed
    2. Uhlirova H, Tian P, Kiliç K, Thunemann M, Sridhar VB, Chmelik R, Bartsch H, Dale AM, Devor A, Saisan PA. Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo. J Vis Exp. 2018 05 04; (135). PMID: 29782006.
      View in: PubMed
    3. Gómez CA, Sutin J, Wu W, Fu B, Uhlirova H, Devor A, Boas DA, Sakadžic S, Yaseen MA. Phasor analysis of NADH FLIM identifies pharmacological disruptions to mitochondrial metabolic processes in the rodent cerebral cortex. PLoS One. 2018; 13(3):e0194578. PMID: 29561904.
      View in: PubMed
    4. Mäki-Marttunen T, Halnes G, Devor A, Metzner C, Dale AM, Andreassen OA, Einevoll GT. A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. J Neurosci Methods. 2018 Jan 01; 293:264-283. PMID: 28993204.
      View in: PubMed
    5. Holter KE, Kehlet B, Devor A, Sejnowski TJ, Dale AM, Omholt SW, Ottersen OP, Nagelhus EA, Mardal KA, Pettersen KH. Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow. Proc Natl Acad Sci U S A. 2017 Sep 12; 114(37):9894-9899. PMID: 28847942.
      View in: PubMed
    6. Yaseen MA, Sutin J, Wu W, Fu B, Uhlirova H, Devor A, Boas DA, Sakadžic S. Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolism in vivo. Biomed Opt Express. 2017 May 01; 8(5):2368-2385. PMID: 28663879.
      View in: PubMed
    7. Uhlirova H, Tian P, Kiliç K, Thunemann M, Sridhar VB, Bartsch H, Dale AM, Devor A, Saisan PA. Neurovascular Network Explorer 2.0: A Database of 2-Photon Single-Vessel Diameter Measurements from Mouse SI Cortex in Response To Optogenetic Stimulation. Front Neuroinform. 2017; 11:4. PMID: 28203155.
      View in: PubMed
    8. Yang MH, Abashin M, Saisan PA, Tian P, Ferri CG, Devor A, Fainman Y. Non-degenerate 2-photon excitation in scattering medium for fluorescence microscopy. Opt Express. 2016 Dec 26; 24(26):30173-30187. PMID: 28059294.
      View in: PubMed
    9. Sakadžic S, Yaseen MA, Jaswal R, Roussakis E, Dale AM, Buxton RB, Vinogradov SA, Boas DA, Devor A. Two-photon microscopy measurement of cerebral metabolic rate of oxygen using periarteriolar oxygen concentration gradients. Neurophotonics. 2016 Oct; 3(4):045005. PMID: 27774493.
      View in: PubMed
    10. Uhlirova H, Kiliç K, Tian P, Sakadžic S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ, Vandenberghe M, Djurovic S, Andreassen OA, Silva GA, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A. The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements. Philos Trans R Soc Lond B Biol Sci. 2016 Oct 05; 371(1705). PMID: 27574309; PMCID: PMC5003857 [Available on 10/05/17].
    11. Gagnon L, Sakadžic S, Lesage F, Pouliot P, Dale AM, Devor A, Buxton RB, Boas DA. Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy. Philos Trans R Soc Lond B Biol Sci. 2016 Oct 05; 371(1705). PMID: 27574311; PMCID: PMC5003859 [Available on 10/05/17].
    12. Gagnon L, Smith AF, Boas DA, Devor A, Secomb TW, Sakadžic S. Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation. Front Comput Neurosci. 2016; 10:82. PMID: 27630556; PMCID: PMC5006088.
    13. Uhlirova H, Kiliç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžic S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A. Cell type specificity of neurovascular coupling in cerebral cortex. Elife. 2016 05 31; 5. PMID: 27244241; PMCID: PMC4933561.
    14. Glabska HT, Norheim E, Devor A, Dale AM, Einevoll GT, Wójcik DK. Generalized Laminar Population Analysis (gLPA) for Interpretation of Multielectrode Data from Cortex. Front Neuroinform. 2016; 10:1. PMID: 26834620; PMCID: PMC4724720.
    15. Wang Y, Thompson WK, Schork AJ, Holland D, Chen CH, Bettella F, Desikan RS, Li W, Witoelar A, Zuber V, Devor A. Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genet. 2016 Jan; 12(1):e1005803. PMID: 26808560; PMCID: PMC4726519.
    16. Mäki-Marttunen T, Halnes G, Devor A, Witoelar A, Bettella F, Djurovic S, Wang Y, Einevoll GT, Andreassen OA, Dale AM. Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan 01; 1(1):49-59. PMID: 26949748.
      View in: PubMed
    17. Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation. 2015 Apr; 22(3):204-218. PMID: 25705966; PMCID: PMC4393797.
    18. Gagnon L, Sakadžic S, Lesage F, Musacchia JJ, Lefebvre J, Fang Q, Yücel MA, Evans KC, Mandeville ET, Cohen-Adad J, Polimeni JR, Yaseen MA, Lo EH, Greve DN, Buxton RB, Dale AM, Devor A, Boas DA. Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe. J Neurosci. 2015 Feb 25; 35(8):3663-75. PMID: 25716864; PMCID: PMC4339366.
    19. Sakadžic S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014 Dec 08; 5:5734. PMID: 25483924; PMCID: PMC4260810.
    20. Devor A, Roe AW, Mahadevan-Jansen A, Boas DA. The BRAIN Initiative. Neurophotonics. 2014 Jul; 1(1):011001. PMID: 26157962; PMCID: PMC4489344.
    21. Sridhar VB, Tian P, Dale AM, Devor A, Saisan PA. Neurovascular Network Explorer 1.0: a database of 2-photon single-vessel diameter measurements with MATLAB(®) graphical user interface. Front Neuroinform. 2014; 8:56. PMID: 24904401; PMCID: PMC4033101.
    22. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. PMID: 24139032.
      View in: PubMed
    23. Nizar K, Uhlirova H, Tian P, Saisan PA, Cheng Q, Reznichenko L, Weldy KL, Steed TC, Sridhar VB, MacDonald CL, Cui J, Gratiy SL, Sakadzic S, Boas DA, Beka TI, Einevoll GT, Chen J, Masliah E, Dale AM, Silva GA, Devor A. In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci. 2013 May 08; 33(19):8411-22. PMID: 23658179; PMCID: PMC3712855.
    24. Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. J Neurosci. 2012 Jul 18; 32(29):9992-8. PMID: 22815513; PMCID: PMC3491088.
    25. Devor A, Sakadžic S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA. Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1259-76. PMID: 22252238; PMCID: PMC3390808.
    26. Devor A, Boas D. Neurovascular imaging. Front Neuroenergetics. 2012; 4:1. PMID: 22279435; PMCID: PMC3260454.
    27. Gratiy SL, Devor A, Einevoll GT, Dale AM. On the estimation of population-specific synaptic currents from laminar multielectrode recordings. Front Neuroinform. 2011; 5:32. PMID: 22203801; PMCID: PMC3243925.
    28. Baraghis E, Devor A, Fang Q, Srinivasan VJ, Wu W, Lesage F, Ayata C, Kasischke KA, Boas DA, Sakadzic S. Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt. 2011 Oct; 16(10):106003. PMID: 22029350; PMCID: PMC3206923.
    29. Devor A, Sakadzic S, Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA. "Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci. 2011 Sep 21; 31(38):13676-81. PMID: 21940458; PMCID: PMC3188944.
    30. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011 May 04; (51). PMID: 21587157; PMCID: PMC3197095.
    31. Tian P, Devor A, Sakadzic S, Dale AM, Boas DA. Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain. J Biomed Opt. 2011 Jan-Feb; 16(1):016006. PMID: 21280912; PMCID: PMC3041814.
    32. Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15246-51. PMID: 20696904; PMCID: PMC2930564.
    33. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997; PMCID: PMC2932799.
    34. Yücel MA, Devor A, Akin A, Boas DA. The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot. Front Neuroenergetics. 2009; 1:7. PMID: 20027233; PMCID: PMC2795469.
    35. Huppert TJ, Jones PB, Devor A, Dunn AK, Teng IC, Dale AM, Boas DA. Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia. J Biomed Opt. 2009 Jul-Aug; 14(4):044038. PMID: 19725749; PMCID: PMC2774124.
    36. Blomquist P, Devor A, Indahl UG, Ulbert I, Einevoll GT, Dale AM. Estimation of thalamocortical and intracortical network models from joint thalamic single-electrode and cortical laminar-electrode recordings in the rat barrel system. PLoS Comput Biol. 2009 Mar; 5(3):e1000328. PMID: 19325875; PMCID: PMC2653726.
    37. Devor A, Hillman EM, Tian P, Waeber C, Teng IC, Ruvinskaya L, Shalinsky MH, Zhu H, Haslinger RH, Narayanan SN, Ulbert I, Dunn AK, Lo EH, Rosen BR, Dale AM, Kleinfeld D, Boas DA. Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci. 2008 Dec 31; 28(53):14347-57. PMID: 19118167; PMCID: PMC2655308.
    38. Chen Y, Aguirre AD, Ruvinskaya L, Devor A, Boas DA, Fujimoto JG. Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation. J Neurosci Methods. 2009 Mar 30; 178(1):162-73. PMID: 19121336; PMCID: PMC3004397.
    39. Fang Q, Sakadzic S, Ruvinskaya L, Devor A, Dale AM, Boas DA. Oxygen advection and diffusion in a three- dimensional vascular anatomical network. Opt Express. 2008 Oct 27; 16(22):17530-41. PMID: 18958033; PMCID: PMC2584207.
    40. Boas DA, Jones SR, Devor A, Huppert TJ, Dale AM. A vascular anatomical network model of the spatio-temporal response to brain activation. Neuroimage. 2008 Apr 15; 40(3):1116-29. PMID: 18289880; PMCID: PMC2577617.
    41. Devor A, Tian P, Nishimura N, Teng IC, Hillman EM, Narayanan SN, Ulbert I, Boas DA, Kleinfeld D, Dale AM. Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci. 2007 Apr 18; 27(16):4452-9. PMID: 17442830; PMCID: PMC2680207.
    42. Hillman EM, Devor A, Bouchard MB, Dunn AK, Krauss GW, Skoch J, Bacskai BJ, Dale AM, Boas DA. Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage. 2007 Mar; 35(1):89-104. PMID: 17222567; PMCID: PMC1994243.
    43. Devor A, Trevelyan A, Kleinfeld D. Is there a common origin to surround-inhibition as seen through electrical activity versus hemodynamic changes? Focus on "Duration-dependent response in SI to vibrotactile stimulation in squirrel monkey". J Neurophysiol. 2007 Mar; 97(3):1880-2. PMID: 17215499.
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    44. Einevoll GT, Pettersen KH, Devor A, Ulbert I, Halgren E, Dale AM. Laminar population analysis: estimating firing rates and evoked synaptic activity from multielectrode recordings in rat barrel cortex. J Neurophysiol. 2007 Mar; 97(3):2174-90. PMID: 17182911.
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    45. Pettersen KH, Devor A, Ulbert I, Dale AM, Einevoll GT. Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuities. J Neurosci Methods. 2006 Jun 30; 154(1-2):116-33. PMID: 16436298.
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    46. Dunn AK, Devor A, Dale AM, Boas DA. Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. Neuroimage. 2005 Aug 15; 27(2):279-90. PMID: 15925522.
      View in: PubMed
    47. Yuan S, Devor A, Boas DA, Dunn AK. Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. Appl Opt. 2005 Apr 01; 44(10):1823-30. PMID: 15813518.
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    48. Devor A, Ulbert I, Dunn AK, Narayanan SN, Jones SR, Andermann ML, Boas DA, Dale AM. Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3822-7. PMID: 15734797; PMCID: PMC550644.
    49. Leergaard TB, Bjaalie JG, Devor A, Wald LL, Dale AM. In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing. Neuroimage. 2003 Nov; 20(3):1591-600. PMID: 14642470.
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    50. Devor A, Dunn AK, Andermann ML, Ulbert I, Boas DA, Dale AM. Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron. 2003 Jul 17; 39(2):353-9. PMID: 12873390.
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    51. De Zeeuw CI, Chorev E, Devor A, Manor Y, Van Der Giessen RS, De Jeu MT, Hoogenraad CC, Bijman J, Ruigrok TJ, French P, Jaarsma D, Kistler WM, Meier C, Petrasch-Parwez E, Dermietzel R, Sohl G, Gueldenagel M, Willecke K, Yarom Y. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J Neurosci. 2003 Jun 01; 23(11):4700-11. PMID: 12805309.
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    52. Dunn AK, Devor A, Bolay H, Andermann ML, Moskowitz MA, Dale AM, Boas DA. Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Opt Lett. 2003 Jan 01; 28(1):28-30. PMID: 12656525.
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    53. Devor A, Yarom Y. Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings. J Neurophysiol. 2002 Jun; 87(6):3048-58. PMID: 12037207.
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    54. Devor A, Yarom Y. Generation and propagation of subthreshold waves in a network of inferior olivary neurons. J Neurophysiol. 2002 Jun; 87(6):3059-69. PMID: 12037208.
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    55. Devor A. The great gate: control of sensory information flow to the cerebellum. Cerebellum. 2002 Jan-Mar; 1(1):27-34. PMID: 12879971.
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