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Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cereb Cortex. 2022 Dec 06.
Barnes SA, Dillon DG, Young JW, Thomas ML, Faget L, Yoo JH, Der-Avakian A, Hnasko TS, Geyer MA, Ramanathan DS. PMID: 36472411.
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Effects of modafinil on electroencephalographic microstates in healthy adults. Psychopharmacology (Berl). 2022 Aug; 239(8):2573-2584.
Linton SR, Murphy M, Schroder HS, Breiger M, Iturra-Mena AM, Kangas BD, Bergman J, Carlezon WA, Risbrough VB, Barnes SA, Der-Avakian A, Pizzagalli DA. PMID: 35471613; PMCID: PMC9296596.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil. J Cogn Neurosci. 2022 03 31; 34(5):864-876.
Schroder HS, Iturra-Mena AM, Breiger M, Linton SR, Robble MA, Kangas BD, Bergman J, Nickels S, Vitaliano G, Der-Avakian A, Barnes SA, Carlezon WA, Pizzagalli DA. PMID: 35195725.
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Humans
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Probabilistic Reinforcement Learning and Anhedonia. Curr Top Behav Neurosci. 2022; 58:355-377.
Kangas BD, Der-Avakian A, Pizzagalli DA. PMID: 35435644.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Concordant neurophysiological signatures of cognitive control in humans and rats. Neuropsychopharmacology. 2021 06; 46(7):1252-1262.
Robble MA, Schroder HS, Kangas BD, Nickels S, Breiger M, Iturra-Mena AM, Perlo S, Cardenas E, Der-Avakian A, Barnes SA, Leutgeb S, Risbrough VB, Vitaliano G, Bergman J, Carlezon WA, Pizzagalli DA. PMID: 33746206; PMCID: PMC8134486.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics. Neurosci Biobehav Rev. 2020 09; 116:452-453.
Silverman JL, Nithianantharajah J, Der-Avakian A, Young JW, Sukoff Rizzo SJ. PMID: 32681939; PMCID: PMC7773218.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Assessing the motivational effects of ethanol in mice using a discrete-trial current-intensity intracranial self-stimulation procedure. Drug Alcohol Depend. 2020 02 01; 207:107806.
Barkley-Levenson AM, Der-Avakian A, Palmer AA. PMID: 31864164; PMCID: PMC6939988.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia. J Neurosci. 2020 01 15; 40(3):569-584.
Prakash N, Stark CJ, Keisler MN, Luo L, Der-Avakian A, Dulcis D. PMID: 31792153; PMCID: PMC6961996.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Overview of the Biography and Legacy of Professor Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):910-912.
Geyer MA, Semenova S, Li X, Der-Avakian A, Barnes SA, Grant I. PMID: 29501205.
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Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):932-939.
Der-Avakian A, Pizzagalli DA. PMID: 29615189; PMCID: PMC5953796.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
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Effects of adolescent alcohol exposure on stress-induced reward deficits, brain CRF, monoamines and glutamate in adult rats. Psychopharmacology (Berl). 2018 03; 235(3):737-747.
Boutros N, Der-Avakian A, Kesby JP, Lee S, Markou A, Semenova S. PMID: 29181815.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation. Biol Psychiatry. 2018 05 15; 83(10):895-907.
Deslauriers J, Toth M, Der-Avakian A, Risbrough VB. PMID: 29338843; PMCID: PMC6085893.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimals
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Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia. Schizophr Bull. 2017 07 01; 43(4):706-711.
Barnes SA, Der-Avakian A, Young JW. PMID: 28586462; PMCID: PMC5472160.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1603-1614.
Der-Avakian A, D'Souza MS, Potter DN, Chartoff EH, Carlezon WA, Pizzagalli DA, Markou A. PMID: 28280884; PMCID: PMC5420477.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1549-1556.
Boutros N, Der-Avakian A, Markou A, Semenova S. PMID: 28197651.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood. Behav Brain Res. 2016 09 15; 311:160-166.
Boutros N, Der-Avakian A, Semenova S, Lee S, Markou A. PMID: 27217101; PMCID: PMC5253236.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders. Curr Top Behav Neurosci. 2016; 28:231-62.
Der-Avakian A, Barnes SA, Markou A, Pizzagalli DA. PMID: 26873017; PMCID: PMC4983255.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimals
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Negative affective states and cognitive impairments in nicotine dependence. Neurosci Biobehav Rev. 2015 Nov; 58:168-85.
Hall FS, Der-Avakian A, Gould TJ, Markou A, Shoaib M, Young JW. PMID: 26054790; PMCID: PMC4670824.
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PubMed Mentions:
28 Fields:
Translation:
Humans
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Dissociation of learned helplessness and fear conditioning in mice: a mouse model of depression. PLoS One. 2015; 10(4):e0125892.
Landgraf D, Long J, Der-Avakian A, Streets M, Welsh DK. PMID: 25928892; PMCID: PMC4416012.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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Association between nicotine withdrawal and reward responsiveness in humans and rats. JAMA Psychiatry. 2014 Nov; 71(11):1238-1245.
Pergadia ML, Der-Avakian A, D'Souza MS, Madden PAF, Heath AC, Shiffman S, Markou A, Pizzagalli DA. PMID: 25208057; PMCID: PMC4353576.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCTClinical Trials
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Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence. J Med Chem. 2014 May 22; 57(10):4154-72.
Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND. PMID: 24735492; PMCID: PMC4033659.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response. Biol Psychiatry. 2014 Oct 01; 76(7):542-9.
Der-Avakian A, Mazei-Robison MS, Kesby JP, Nestler EJ, Markou A. PMID: 24576687; PMCID: PMC4117827.
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PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
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Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia. Eur Neuropsychopharmacol. 2014 May; 24(5):744-58.
Barnes SA, Der-Avakian A, Markou A. PMID: 24183826; PMCID: PMC3986268.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research. Transl Psychiatry. 2013 Aug 27; 3:e297.
Der-Avakian A, D'Souza MS, Pizzagalli DA, Markou A. PMID: 23982629; PMCID: PMC3756297.
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PubMed Mentions:
51 Fields:
Translation:
Animals
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The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci. 2012 Jan; 35(1):68-77.
Der-Avakian A, Markou A. PMID: 22177980; PMCID: PMC3253139.
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PubMed Mentions:
343 Fields:
Translation:
HumansAnimals
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Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference. Eur J Neurosci. 2012 Jan; 35(1):160-5.
Rozeske RR, Der-Avakian A, Watkins LR, Maier SF. PMID: 22118376; PMCID: PMC3251642.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats. Neuroscience. 2010 Nov 10; 170(4):1189-98.
Der-Avakian A, Markou A. PMID: 20691770; PMCID: PMC2949486.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats. Behav Pharmacol. 2010 Jul; 21(4):359-68.
Der-Avakian A, Markou A. PMID: 20571366; PMCID: PMC4082429.
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PubMed Mentions:
26 Fields:
Translation:
Animals
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The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology. 2009 Mar; 34(4):834-43.
Rozeske RR, Der-Avakian A, Bland ST, Beckley JT, Watkins LR, Maier SF. PMID: 18368036; PMCID: PMC2653625.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression. Psychoneuroendocrinology. 2007 May; 32(4):376-84.
Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF. PMID: 17383826.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology (Berl). 2007 May; 191(4):909-17.
Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. PMID: 17211647.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats. Psychopharmacology (Berl). 2007 May; 191(4):899-907.
Der-Avakian A, Rozeske RR, Bland ST, Watkins LR, Maier SF. PMID: 17211648.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine. Psychoneuroendocrinology. 2006 Jun; 31(5):653-63.
Der-Avakian A, Bland ST, Schmid MJ, Watkins LR, Spencer RL, Maier SF. PMID: 16584846.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci. 2005 Aug 31; 25(35):8000-9.
Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. PMID: 16135757; PMCID: PMC6725459.
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PubMed Mentions:
101 Fields:
Translation:
Animals
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Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. Brain Res. 2005 Jul 27; 1051(1-2):90-9.
Bland ST, Schmid MJ, Der-Avakian A, Watkins LR, Spencer RL, Maier SF. PMID: 15993862.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats. Psychopharmacology (Berl). 2005 May; 179(2):409-17.
Der-Avakian A, Will MJ, Bland ST, Deak T, Nguyen KT, Schmid MJ, Spencer RL, Watkins LR, Maier SF. PMID: 15821955.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. 2004; 126(3):705-15.
Bland ST, Twining C, Schmid MJ, Der-Avakian A, Watkins LR, Maier SF. PMID: 15183519.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats. Psychopharmacology (Berl). 2004 Jan; 171(2):191-8.
Will MJ, Der-Avakian A, Bland ST, Grahn RE, Hammack SE, Sparks PD, Pepin JL, Watkins LR, Maier SF. PMID: 13680080.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci. 2003 Feb 01; 23(3):1019-25.
Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF. PMID: 12574432; PMCID: PMC6741923.
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PubMed Mentions:
86 Fields:
Translation:
Animals
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Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress. Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):345-51.
Will MJ, Der-Avakian A, Pepin JL, Durkan BT, Watkins LR, Maier SF. PMID: 11812543.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol. 1999 Dec 15; 216(2):595-610.
de la Cruz CC, Der-Avakian A, Spyropoulos DD, Tieu DD, Carpenter EM. PMID: 10642795.
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PubMed Mentions:
18 Fields:
Translation:
Animals