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    Der-Avakian, Andre

    TitleAssistant Research Scientist
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0603
    CA La Jolla 92093
    Phone858-534-3893
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      Biography

      Andre Der-Avakian, Ph.D. is an Assistant Research Scientist in the Department of Psychiatry at the University of California, San Diego. His research is focused on the development of novel cross-species translational behavioral tests of reward processing in rodents. Specifically, he is interested in stress-induced disruption of reward processing as it relates to the symptom of anhedonia, or loss of pleasure, seen in several psychiatric disorders like depression, schizophrenia, and drug addiction. Current projects include investigation of metabotropic glutamate 2/3 receptors in stress-induced anhedonia. Dr. Der-Avakian is also interested in understanding the neurobiological factors that promote resilience to stress-induced anhedonia.

      Dr. Der-Avakian received a B.A. in Psychology from the University of California, Los Angeles and a Ph.D. in Neuroscience and Psychology from the University of Colorado, Boulder. He completed his postdoctoral training in the Department of Psychiatry at the University of California, San Diego, where he was awarded a National Research Service Award from the National Institute of Mental Health.


      Collapse Research 
      Collapse Research Activities and Funding
      Lead optimization of Novel mGlu2 Negative Allosteric Modulators
      NIH/NIMH R01MH106865Apr 1, 2016 - Jan 31, 2019
      Role: Co-Principal Investigator
      A Translational Investigation of Anhedonia and its Underlying Neural Mechanisms
      NIH/NIMH F32MH080585Sep 18, 2008 - Sep 17, 2011
      Role: Principal Investigator

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Barnes SA, Der-Avakian A, Young JW. Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia. Schizophr Bull. 2017 Jun 06. PMID: 28586462.
        View in: PubMed
      2. Der-Avakian A, D'Souza MS, Potter DN, Chartoff EH, Carlezon WA, Pizzagalli DA, Markou A. Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats. Psychopharmacology (Berl). 2017 May; 234(9-10):1603-1614. PMID: 28280884.
        View in: PubMed
      3. Boutros N, Der-Avakian A, Markou A, Semenova S. Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats. Psychopharmacology (Berl). 2017 May; 234(9-10):1549-1556. PMID: 28197651.
        View in: PubMed
      4. Boutros N, Der-Avakian A, Semenova S, Lee S, Markou A. Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood. Behav Brain Res. 2016 Sep 15; 311:160-6. PMID: 27217101.
        View in: PubMed
      5. Der-Avakian A, Barnes SA, Markou A, Pizzagalli DA. Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders. Curr Top Behav Neurosci. 2016; 28:231-62. PMID: 26873017; NIHMSID: NIHMS777531 [Available on 01/01/17].
        View in: PubMed
      6. Hall FS, Der-Avakian A, Gould TJ, Markou A, Shoaib M, Young JW. Negative affective states and cognitive impairments in nicotine dependence. Neurosci Biobehav Rev. 2015 Jun 6. PMID: 26054790.
        View in: PubMed
      7. Landgraf D, Long J, Der-Avakian A, Streets M, Welsh DK. Dissociation of learned helplessness and fear conditioning in mice: a mouse model of depression. PLoS One. 2015; 10(4):e0125892. PMID: 25928892.
        View in: PubMed
      8. Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND. Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence. J Med Chem. 2014 May 22; 57(10):4154-72. PMID: 24735492.
        View in: PubMed
      9. Der-Avakian A, Mazei-Robison MS, Kesby JP, Nestler EJ, Markou A. Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response. Biol Psychiatry. 2014 Oct 1; 76(7):542-9. PMID: 24576687.
        View in: PubMed
      10. Barnes SA, Der-Avakian A, Markou A. Anhedonia, avolition, and anticipatory deficits: Assessments in animals with relevance to the negative symptoms of schizophrenia. Eur Neuropsychopharmacol. 2014 May; 24(5):744-58. PMID: 24183826.
        View in: PubMed
      11. Der-Avakian A, D'Souza MS, Pizzagalli DA, Markou A. Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research. Transl Psychiatry. 2013; 3:e297. PMID: 23982629.
        View in: PubMed
      12. Der-Avakian A, Markou A. The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci. 2012 Jan; 35(1):68-77. PMID: 22177980.
        View in: PubMed
      13. Rozeske RR, Der-Avakian A, Watkins LR, Maier SF. Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference. Eur J Neurosci. 2012 Jan; 35(1):160-5. PMID: 22118376.
        View in: PubMed
      14. Der-Avakian A, Markou A. Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats. Neuroscience. 2010 Nov 10; 170(4):1189-98. PMID: 20691770.
        View in: PubMed
      15. Der-Avakian A, Markou A. Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats. Behav Pharmacol. 2010 Jul; 21(4):359-68. PMID: 20571366.
        View in: PubMed
      16. Rozeske RR, Der-Avakian A, Bland ST, Beckley JT, Watkins LR, Maier SF. The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology. 2009 Mar; 34(4):834-43. PMID: 18368036.
        View in: PubMed
      17. Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF. Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression. Psychoneuroendocrinology. 2007 May; 32(4):376-84. PMID: 17383826.
        View in: PubMed
      18. Der-Avakian A, Rozeske RR, Bland ST, Watkins LR, Maier SF. The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats. Psychopharmacology (Berl). 2007 May; 191(4):899-907. PMID: 17211648.
        View in: PubMed
      19. Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology (Berl). 2007 May; 191(4):909-17. PMID: 17211647.
        View in: PubMed
      20. Der-Avakian A, Bland ST, Schmid MJ, Watkins LR, Spencer RL, Maier SF. The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine. Psychoneuroendocrinology. 2006 Jun; 31(5):653-63. PMID: 16584846.
        View in: PubMed
      21. Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci. 2005 Aug 31; 25(35):8000-9. PMID: 16135757.
        View in: PubMed
      22. Bland ST, Schmid MJ, Der-Avakian A, Watkins LR, Spencer RL, Maier SF. Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. Brain Res. 2005 Jul 27; 1051(1-2):90-9. PMID: 15993862.
        View in: PubMed
      23. Der-Avakian A, Will MJ, Bland ST, Deak T, Nguyen KT, Schmid MJ, Spencer RL, Watkins LR, Maier SF. Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats. Psychopharmacology (Berl). 2005 May; 179(2):409-17. PMID: 15821955.
        View in: PubMed
      24. Bland ST, Twining C, Schmid MJ, Der-Avakian A, Watkins LR, Maier SF. Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. 2004; 126(3):705-15. PMID: 15183519.
        View in: PubMed
      25. Will MJ, Der-Avakian A, Bland ST, Grahn RE, Hammack SE, Sparks PD, Pepin JL, Watkins LR, Maier SF. Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats. Psychopharmacology (Berl). 2004 Jan; 171(2):191-8. PMID: 13680080.
        View in: PubMed
      26. Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF. Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci. 2003 Feb 1; 23(3):1019-25. PMID: 12574432.
        View in: PubMed
      27. Will MJ, Der-Avakian A, Pepin JL, Durkan BT, Watkins LR, Maier SF. Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress. Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):345-51. PMID: 11812543.
        View in: PubMed
      28. de la Cruz CC, Der-Avakian A, Spyropoulos DD, Tieu DD, Carpenter EM. Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol. 1999 Dec 15; 216(2):595-610. PMID: 10642795.
        View in: PubMed
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