Andre Der-avakian

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Andre Der-Avakian, Ph.D. is an Assistant Research Scientist in the Department of Psychiatry at the University of California, San Diego. His research is focused on the development of novel cross-species translational behavioral tests of reward processing in rodents. Specifically, he is interested in stress-induced disruption of reward processing as it relates to the symptom of anhedonia, or loss of pleasure, seen in several psychiatric disorders like depression, schizophrenia, and drug addiction. Current projects include investigation of metabotropic glutamate 2/3 receptors in stress-induced anhedonia. Dr. Der-Avakian is also interested in understanding the neurobiological factors that promote resilience to stress-induced anhedonia.

    Dr. Der-Avakian received a B.A. in Psychology from the University of California, Los Angeles and a Ph.D. in Neuroscience and Psychology from the University of Colorado, Boulder. He completed his postdoctoral training in the Department of Psychiatry at the University of California, San Diego, where he was awarded a National Research Service Award from the National Institute of Mental Health.

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    PAASPort: A web-based tool for nonclinical research quality assessment and risk of bias management to advance development of innovative medications
    NIH R44DA050162Feb 1, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Preclinical neurophysiological and behavioral assays of motivation and effort
    NIH R01MH121352Sep 5, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Developing rodent models of PTSD/AUD: leveraging clinic-based strategies
    NIH R01AA026560Sep 12, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Lead optimization of Novel mGlu2 Negative Allosteric Modulators
    NIH R01MH106865Apr 1, 2016 - Jan 31, 2020
    Role: Co-Principal Investigator
    A Translational Investigation of Anhedonia and its Underlying Neural Mechanisms
    NIH F32MH080585Sep 18, 2008 - Sep 17, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cereb Cortex. 2023 05 09; 33(10):5783-5796. Barnes SA, Dillon DG, Young JW, Thomas ML, Faget L, Yoo JH, Der-Avakian A, Hnasko TS, Geyer MA, Ramanathan DS. PMID: 36472411; PMCID: PMC10183731.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    2. Effects of modafinil on electroencephalographic microstates in healthy adults. Psychopharmacology (Berl). 2022 Aug; 239(8):2573-2584. Linton SR, Murphy M, Schroder HS, Breiger M, Iturra-Mena AM, Kangas BD, Bergman J, Carlezon WA, Risbrough VB, Barnes SA, Der-Avakian A, Pizzagalli DA. PMID: 35471613; PMCID: PMC9296596.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil. J Cogn Neurosci. 2022 03 31; 34(5):864-876. Schroder HS, Iturra-Mena AM, Breiger M, Linton SR, Robble MA, Kangas BD, Bergman J, Nickels S, Vitaliano G, Der-Avakian A, Barnes SA, Carlezon WA, Pizzagalli DA. PMID: 35195725.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Probabilistic Reinforcement Learning and Anhedonia. Curr Top Behav Neurosci. 2022; 58:355-377. Kangas BD, Der-Avakian A, Pizzagalli DA. PMID: 35435644.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    5. Concordant neurophysiological signatures of cognitive control in humans and rats. Neuropsychopharmacology. 2021 06; 46(7):1252-1262. Robble MA, Schroder HS, Kangas BD, Nickels S, Breiger M, Iturra-Mena AM, Perlo S, Cardenas E, Der-Avakian A, Barnes SA, Leutgeb S, Risbrough VB, Vitaliano G, Bergman J, Carlezon WA, Pizzagalli DA. PMID: 33746206; PMCID: PMC8134486.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    6. Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics. Neurosci Biobehav Rev. 2020 09; 116:452-453. Silverman JL, Nithianantharajah J, Der-Avakian A, Young JW, Sukoff Rizzo SJ. PMID: 32681939; PMCID: PMC7773218.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    7. Assessing the motivational effects of ethanol in mice using a discrete-trial current-intensity intracranial self-stimulation procedure. Drug Alcohol Depend. 2020 02 01; 207:107806. Barkley-Levenson AM, Der-Avakian A, Palmer AA. PMID: 31864164; PMCID: PMC6939988.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia. J Neurosci. 2020 01 15; 40(3):569-584. Prakash N, Stark CJ, Keisler MN, Luo L, Der-Avakian A, Dulcis D. PMID: 31792153; PMCID: PMC6961996.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    9. Overview of the Biography and Legacy of Professor Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):910-912. Geyer MA, Semenova S, Li X, Der-Avakian A, Barnes SA, Grant I. PMID: 29501205.
      View in: PubMed   Mentions:    Fields:    
    10. Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):932-939. Der-Avakian A, Pizzagalli DA. PMID: 29615189; PMCID: PMC5953796.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    11. Effects of adolescent alcohol exposure on stress-induced reward deficits, brain CRF, monoamines and glutamate in adult rats. Psychopharmacology (Berl). 2018 03; 235(3):737-747. Boutros N, Der-Avakian A, Kesby JP, Lee S, Markou A, Semenova S. PMID: 29181815.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    12. Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation. Biol Psychiatry. 2018 05 15; 83(10):895-907. Deslauriers J, Toth M, Der-Avakian A, Risbrough VB. PMID: 29338843; PMCID: PMC6085893.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    13. Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia. Schizophr Bull. 2017 07 01; 43(4):706-711. Barnes SA, Der-Avakian A, Young JW. PMID: 28586462; PMCID: PMC5472160.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    14. Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1603-1614. Der-Avakian A, D'Souza MS, Potter DN, Chartoff EH, Carlezon WA, Pizzagalli DA, Markou A. PMID: 28280884; PMCID: PMC5420477.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    15. Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1549-1556. Boutros N, Der-Avakian A, Markou A, Semenova S. PMID: 28197651.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    16. Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood. Behav Brain Res. 2016 09 15; 311:160-166. Boutros N, Der-Avakian A, Semenova S, Lee S, Markou A. PMID: 27217101; PMCID: PMC5253236.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    17. Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders. Curr Top Behav Neurosci. 2016; 28:231-62. Der-Avakian A, Barnes SA, Markou A, Pizzagalli DA. PMID: 26873017; PMCID: PMC4983255.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    18. Negative affective states and cognitive impairments in nicotine dependence. Neurosci Biobehav Rev. 2015 Nov; 58:168-85. Hall FS, Der-Avakian A, Gould TJ, Markou A, Shoaib M, Young JW. PMID: 26054790; PMCID: PMC4670824.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    19. Dissociation of learned helplessness and fear conditioning in mice: a mouse model of depression. PLoS One. 2015; 10(4):e0125892. Landgraf D, Long J, Der-Avakian A, Streets M, Welsh DK. PMID: 25928892; PMCID: PMC4416012.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    20. Association between nicotine withdrawal and reward responsiveness in humans and rats. JAMA Psychiatry. 2014 Nov; 71(11):1238-1245. Pergadia ML, Der-Avakian A, D'Souza MS, Madden PAF, Heath AC, Shiffman S, Markou A, Pizzagalli DA. PMID: 25208057; PMCID: PMC4353576.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCTClinical Trials
    21. Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence. J Med Chem. 2014 May 22; 57(10):4154-72. Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND. PMID: 24735492; PMCID: PMC4033659.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    22. Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response. Biol Psychiatry. 2014 Oct 01; 76(7):542-9. Der-Avakian A, Mazei-Robison MS, Kesby JP, Nestler EJ, Markou A. PMID: 24576687; PMCID: PMC4117827.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    23. Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia. Eur Neuropsychopharmacol. 2014 May; 24(5):744-58. Barnes SA, Der-Avakian A, Markou A. PMID: 24183826; PMCID: PMC3986268.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    24. Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research. Transl Psychiatry. 2013 Aug 27; 3:e297. Der-Avakian A, D'Souza MS, Pizzagalli DA, Markou A. PMID: 23982629; PMCID: PMC3756297.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    25. The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci. 2012 Jan; 35(1):68-77. Der-Avakian A, Markou A. PMID: 22177980; PMCID: PMC3253139.
      View in: PubMed   Mentions: 385     Fields:    Translation:HumansAnimals
    26. Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference. Eur J Neurosci. 2012 Jan; 35(1):160-5. Rozeske RR, Der-Avakian A, Watkins LR, Maier SF. PMID: 22118376; PMCID: PMC3251642.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    27. Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats. Neuroscience. 2010 Nov 10; 170(4):1189-98. Der-Avakian A, Markou A. PMID: 20691770; PMCID: PMC2949486.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    28. Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats. Behav Pharmacol. 2010 Jul; 21(4):359-68. Der-Avakian A, Markou A. PMID: 20571366; PMCID: PMC4082429.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    29. The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology. 2009 Mar; 34(4):834-43. Rozeske RR, Der-Avakian A, Bland ST, Beckley JT, Watkins LR, Maier SF. PMID: 18368036; PMCID: PMC2653625.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    30. Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression. Psychoneuroendocrinology. 2007 May; 32(4):376-84. Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF. PMID: 17383826.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    31. The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology (Berl). 2007 May; 191(4):909-17. Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. PMID: 17211647.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    32. The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats. Psychopharmacology (Berl). 2007 May; 191(4):899-907. Der-Avakian A, Rozeske RR, Bland ST, Watkins LR, Maier SF. PMID: 17211648.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    33. The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine. Psychoneuroendocrinology. 2006 Jun; 31(5):653-63. Der-Avakian A, Bland ST, Schmid MJ, Watkins LR, Spencer RL, Maier SF. PMID: 16584846.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    34. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci. 2005 Aug 31; 25(35):8000-9. Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. PMID: 16135757; PMCID: PMC6725459.
      View in: PubMed   Mentions: 104     Fields:    Translation:Animals
    35. Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. Brain Res. 2005 Jul 27; 1051(1-2):90-9. Bland ST, Schmid MJ, Der-Avakian A, Watkins LR, Spencer RL, Maier SF. PMID: 15993862.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    36. Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats. Psychopharmacology (Berl). 2005 May; 179(2):409-17. Der-Avakian A, Will MJ, Bland ST, Deak T, Nguyen KT, Schmid MJ, Spencer RL, Watkins LR, Maier SF. PMID: 15821955.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    37. Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. 2004; 126(3):705-15. Bland ST, Twining C, Schmid MJ, Der-Avakian A, Watkins LR, Maier SF. PMID: 15183519.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    38. Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats. Psychopharmacology (Berl). 2004 Jan; 171(2):191-8. Will MJ, Der-Avakian A, Bland ST, Grahn RE, Hammack SE, Sparks PD, Pepin JL, Watkins LR, Maier SF. PMID: 13680080.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    39. Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci. 2003 Feb 01; 23(3):1019-25. Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF. PMID: 12574432; PMCID: PMC6741923.
      View in: PubMed   Mentions: 87     Fields:    Translation:Animals
    40. Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress. Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):345-51. Will MJ, Der-Avakian A, Pepin JL, Durkan BT, Watkins LR, Maier SF. PMID: 11812543.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    41. Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol. 1999 Dec 15; 216(2):595-610. de la Cruz CC, Der-Avakian A, Spyropoulos DD, Tieu DD, Carpenter EM. PMID: 10642795.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
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