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Amy Tsai

TitleRecall Non-faculty Academic
InstitutionUniversity of California San Diego
DepartmentBioengineering
Address9500 Gilman Drive #0412
La Jolla CA 92093
Phone858-534-5847
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    Collapse Research 
    Collapse Research Activities and Funding
    Plasma hyperviscosity for the reversal of hypovolemic cardiovascular collapse
    NIH/NHLBI R01HL076182Jan 1, 2004 - Dec 31, 2008
    Role: Principal Investigator
    CRITICAL MICROVASCULAR OXYGEN FLUCTUATIONS
    NIH/NHLBI F32HL008343Dec 24, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aghaeepour N, Kin C, Ganio EA, Jensen KP, Gaudilliere DK, Tingle M, Tsai A, Lancero HL, Choisy B, McNeil LS, Okada R, Shelton AA, Nolan GP, Angst MS, Gaudilliere BL. Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery. J Immunol. 2017 Aug 09. PMID: 28794234.
      View in: PubMed
    2. Zimmerman R, Tsai AG, Salazar Vázquez BY, Cabrales P, Hofmann A, Meier J, Shander A, Spahn DR, Friedman JM, Tartakovsky DM, Intaglietta M. Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity. Anesth Analg. 2017 05; 124(5):1547-1554. PMID: 28328758.
      View in: PubMed
    3. Martucci AF, Abreu Martucci AC, Cabrales P, Nascimento PD, Intaglietta M, Tsai AG, Castiglia YM. Acute kidney function and morphology following topload administration of recombinant hemoglobin solution. Artif Cells Nanomed Biotechnol. 2017 Feb; 45(1):24-30. PMID: 27797281.
      View in: PubMed
    4. Tsai AG, Vázquez BY, Hofmann A, Acharya SA, Intaglietta M. Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions? J Infus Nurs. 2015 May-Jun; 38(3):217-22. PMID: 25871869.
      View in: PubMed
    5. Tsai AG, Salazar Vázquez BY, Cabrales P, Kistler EB, Tartakovsky DM, Subramaniam S, Acharya SA, Intaglietta M. Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies. J Funct Biomater. 2014 Oct 27; 5(4):232-45. PMID: 25350267; PMCID: PMC4285404.
    6. Tsai AG, Cabrales P, Young MA, Winslow RM, Intaglietta M. Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia. Artif Cells Nanomed Biotechnol. 2015 Feb; 43(1):10-7. PMID: 25060721.
      View in: PubMed
    7. Meng F, Tsai AG, Intaglietta M, Acharya SA. PEGylation of aa-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG aa-Hbs. Artif Cells Nanomed Biotechnol. 2015; 43(4):270-81. PMID: 24597567; PMCID: PMC4167218.
    8. Martini J, Cabrales P, Fries D, Intaglietta M, Tsai AG. Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*. Crit Care Med. 2013 Nov; 41(11):e301-8. PMID: 23978812; PMCID: PMC4109711.
    9. McQueen FM, Doyle A, Reeves Q, Gao A, Tsai A, Gamble GD, Curteis B, Williams M, Dalbeth N. Bone erosions in patients with chronic gouty arthropathy are associated with tophi but not bone oedema or synovitis: new insights from a 3 T MRI study. Rheumatology (Oxford). 2014 Jan; 53(1):95-103. PMID: 24080252.
      View in: PubMed
    10. Yalcin O, Ortiz D, Tsai AG, Johnson PC, Cabrales P. Microhemodynamic aberrations created by transfusion of stored blood. Transfusion. 2014 Apr; 54(4):1015-27. PMID: 23901933; PMCID: PMC4105299.
    11. Tsai AG, Intaglietta M, Sakai H, Delpy E, La Rochelle CD, Rousselot M, Zal F. Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier. Curr Drug Discov Technol. 2012 Sep; 9(3):166-72. PMID: 22564165.
      View in: PubMed
    12. Sriram K, Salazar Vázquez BY, Tsai AG, Cabrales P, Intaglietta M, Tartakovsky DM. Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1096-106. PMID: 22923620; PMCID: PMC3517642.
    13. Hightower CM, Salazar Vázquez BY, Cabrales P, Tsai AG, Acharya SA, Intaglietta M. Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage. Transfusion. 2013 Jan; 53(1):49-59. PMID: 22554380; PMCID: PMC4517570.
    14. Sriram K, Tsai AG, Cabrales P, Meng F, Acharya SA, Tartakovsky DM, Intaglietta M. PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2489-97. PMID: 22505638; PMCID: PMC3378262.
    15. Villela NR, Tsai AG, Cabrales P, Intaglietta M. Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model. J Trauma. 2011 Aug; 71(2):418-24. PMID: 21248647.
      View in: PubMed
    16. Vázquez BY, Hightower CM, Martini J, Messmer C, Frienesenecker B, Corbels P, Tsai AG, Intaglietta M. Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock. Crit Care Med. 2011 Jun; 39(6):1461-6. PMID: 21336111; PMCID: PMC3318980.
    17. Hightower CM, Salazar Vázquez BY, Woo Park S, Sriram K, Martini J, Yalcin O, Tsai AG, Cabrales P, Tartakovsky DM, Johnson PC, Intaglietta M. Integration of cardiovascular regulation by the blood/endothelium cell-free layer. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug; 3(4):458-70. PMID: 21523919.
      View in: PubMed
    18. Salazar Vázquez BY, Cabrales P, Tsai AG, Intaglietta M. Nonlinear cardiovascular regulation consequent to changes in blood viscosity. Clin Hemorheol Microcirc. 2011; 49(1-4):29-36. PMID: 22214675.
      View in: PubMed
    19. Vázquez BY, Martini J, Tsai AG, Johnson PC, Cabrales P, Intaglietta M. The variability of blood pressure due to small changes of hematocrit. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H863-7. PMID: 20601464; PMCID: PMC2944491.
    20. Tsai AG, Hofmann A, Cabrales P, Intaglietta M. Perfusion vs. oxygen delivery in transfusion with "fresh" and "old" red blood cells: the experimental evidence. Transfus Apher Sci. 2010 Aug; 43(1):69-78. PMID: 20646963; PMCID: PMC2918661.
    21. Tsai AG, Cabrales P, Intaglietta M. The physics of oxygen delivery: facts and controversies. Antioxid Redox Signal. 2010 Mar 15; 12(6):683-91. PMID: 19757988; PMCID: PMC2834451.
    22. Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials. 2010 May; 31(13):3723-35. PMID: 20149433; PMCID: PMC2837140.
    23. Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Physiol (1985). 2009 Nov; 107(5):1548-58. PMID: 19745190; PMCID: PMC2777796.
    24. Cabrales P, Tsai AG. Will fixing the vasoactivity caused by hemoglobin-based oxygen carriers be enough? Crit Care Med. 2009 Jun; 37(6):2125-6. PMID: 19448469.
      View in: PubMed
    25. Meng F, Manjula BN, Tsai AG, Cabrales P, Intaglietta M, Smith PK, Prabhakaran M, Acharya SA. Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts. Protein J. 2009 Jun; 28(5):199-212. PMID: 19653083.
      View in: PubMed
    26. Villela NR, Cabrales P, Tsai AG, Intaglietta M. Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model. Shock. 2009 Jun; 31(6):645-52. PMID: 18948853.
      View in: PubMed
    27. Cabrales P, Tsai AG, Intaglietta M. Exogenous nitric oxide induces protection during hemorrhagic shock. Resuscitation. 2009 Jun; 80(6):707-12. PMID: 19362408; PMCID: PMC2747810.
    28. Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar; 31(3):300-7. PMID: 18636045.
      View in: PubMed
    29. Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2212-8. PMID: 18835914; PMCID: PMC2614583.
    30. Cabrales P, Tsai AG, Ananda K, Acharya SA, Intaglietta M. Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. Resuscitation. 2008 Oct; 79(1):139-46. PMID: 18621463; PMCID: PMC2758307.
    31. Cabrales P, Tsai AG, Intaglietta M. Balance between vasoconstriction and enhanced oxygen delivery. Transfusion. 2008 Oct; 48(10):2087-95. PMID: 18631171; PMCID: PMC2747808.
    32. Mao Q, Gundavarapu S, Patel C, Tsai A, Luks FI, De Paepe ME. The Fas system confers protection against alveolar disruption in hyperoxia-exposed newborn mice. Am J Respir Cell Mol Biol. 2008 Dec; 39(6):717-29. PMID: 18587053; PMCID: PMC2586047.
    33. Salazar Vázquez BY, Wettstein R, Cabrales P, Tsai AG, Intaglietta M. Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation. Biochim Biophys Acta. 2008 Oct; 1784(10):1421-7. PMID: 18502215; PMCID: PMC2886513.
    34. Martini J, Cabrales P, K A, Acharya SA, Intaglietta M, Tsai AG. Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Crit Care. 2008; 12(2):R54. PMID: 18423033; PMCID: PMC2447609.
    35. Cabrales P, Tsai AG, Intaglietta M. Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock. Resuscitation. 2008 Jun; 77(3):379-86. PMID: 18308459; PMCID: PMC3224810.
    36. Cabrales P, Tsai AG, Intaglietta M. Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes. Shock. 2007 Oct; 28(4):461-7. PMID: 17558350.
      View in: PubMed
    37. Cabrales P, Tsai AG, Intaglietta M. Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):354-61. PMID: 17884988; PMCID: PMC2258455.
    38. Salazar Vázquez BY, Cabrales P, Tsai AG, Johnson PC, Intaglietta M. Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):135-42. PMID: 17709601; PMCID: PMC2214674.
    39. Acharya SA, Acharya VN, Kanika ND, Tsai AG, Intaglietta M, Manjula BN. Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation. Biochem J. 2007 Aug 01; 405(3):503-11. PMID: 17425516; PMCID: PMC2267292.
    40. Tsai AG, Johnson PC, Intaglietta M. Is the distribution of tissue pO(2) homogeneous? Antioxid Redox Signal. 2007 Jul; 9(7):979-84. PMID: 17508919.
      View in: PubMed
    41. Cabrales P, Intaglietta M, Tsai AG. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation. 2007 Oct; 75(1):124-34. PMID: 17481796; PMCID: PMC3224809.
    42. Tsai AG, Cabrales P, Johnson PC, Intaglietta M. New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions. J Appl Physiol (1985). 2007 May; 102(5):2081-2; author reply 2083. PMID: 17483445.
      View in: PubMed
    43. Hangai-Hoger N, Tsai AG, Cabrales P, Suematsu M, Intaglietta M. Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. Crit Care Med. 2007 Apr; 35(4):1123-32. PMID: 17334240.
      View in: PubMed
    44. Cabrales P, Tsai AG, Intaglietta M. Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity? Shock. 2007 Apr; 27(4):380-9. PMID: 17414420.
      View in: PubMed
    45. Cabrales P, Vázquez BY, Tsai AG, Intaglietta M. Microvascular and capillary perfusion following glycocalyx degradation. J Appl Physiol (1985). 2007 Jun; 102(6):2251-9. PMID: 17347383.
      View in: PubMed
    46. Cabrales P, Tsai AG, Intaglietta M. Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin. Antioxid Redox Signal. 2007 Mar; 9(3):375-84. PMID: 17184174.
      View in: PubMed
    47. Cabrales P, Tsai AG, Intaglietta M. Perfluorocarbon in microcirculation during ischemia reperfusion. J Am Coll Surg. 2007 Feb; 204(2):225-35. PMID: 17254926.
      View in: PubMed
    48. Hangai-Hoger N, Tsai AG, Cabrales P, Intaglietta M. Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2. Lymphat Res Biol. 2007; 5(3):159-68. PMID: 18035934.
      View in: PubMed
    49. Cabrales P, Tsai AG, Intaglietta M. Hemorrhagic shock resuscitation with carbon monoxide saturated blood. Resuscitation. 2007 Feb; 72(2):306-18. PMID: 17092627.
      View in: PubMed
    50. Wettstein R, Tsai AG, Harder Y, Erni D, Intaglietta M. Early resuscitation with polymerized bovine hemoglobin reverses acidosis, but not peripheral tissue oxygenation, in a severe hamster shock model. Shock. 2006 Nov; 26(5):496-503. PMID: 17047521.
      View in: PubMed
    51. Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M. Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood. 2006 Nov 15; 108(10):3603-10. PMID: 16857991; PMCID: PMC1895434.
    52. Wettstein R, Erni D, Intaglietta M, Tsai AG. Rapid restoration of microcirculatory blood flow with hyperviscous and hyperoncotic solutions lowers the transfusion trigger in resuscitation from hemorrhagic shock. Shock. 2006 Jun; 25(6):641-6. PMID: 16721273.
      View in: PubMed
    53. Cabrales P, Tsai AG. Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2445-52. PMID: 16731641.
      View in: PubMed
    54. Friesenecker BE, Tsai AG, Martini J, Ulmer H, Wenzel V, Hasibeder WR, Intaglietta M, Dünser MW. Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine. Crit Care. 2006; 10(3):R75. PMID: 16696866; PMCID: PMC1550934.
    55. Tsai AG, Cabrales P. Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored? Crit Care Med. 2006 May; 34(5):1566-7. PMID: 16633264.
      View in: PubMed
    56. Cabrales P, Martini J, Intaglietta M, Tsai AG. Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H581-90. PMID: 16517943.
      View in: PubMed
    57. Martini J, Tsai AG, Cabrales P, Johnson PC, Intaglietta M. Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H310-7. PMID: 16489106.
      View in: PubMed
    58. Hangai-Hoger N, Nacharaju P, Manjula BN, Cabrales P, Tsai AG, Acharya SA, Intaglietta M. Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia. Crit Care Med. 2006 Jan; 34(1):108-17. PMID: 16374164.
      View in: PubMed
    59. Tsai AG, Friesenecker B, Cabrales P, Hangai-Hoger N, Intaglietta M. The vascular wall as a regulator of tissue oxygenation. Curr Opin Nephrol Hypertens. 2006 Jan; 15(1):67-71. PMID: 16340669.
      View in: PubMed
    60. Intaglietta M, Cabrales P, Tsai AG. Microvascular perspective of oxygen-carrying and -noncarrying blood substitutes. Annu Rev Biomed Eng. 2006; 8:289-321. PMID: 16834558.
      View in: PubMed
    61. Cabrales P, Tsai AG, Johnson PC, Intaglietta M. Oxygen release from arterioles with normal flow and no-flow conditions. J Appl Physiol (1985). 2006 May; 100(5):1569-76. PMID: 16384838.
      View in: PubMed
    62. Cabrales P, Tsai AG, Intaglietta M. Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia. J Appl Physiol (1985). 2006 Apr; 100(4):1181-7. PMID: 16357070.
      View in: PubMed
    63. Cabrales P, Tsai AG, Frangos JA, Intaglietta M. Role of endothelial nitric oxide in microvascular oxygen delivery and consumption. Free Radic Biol Med. 2005 Nov 01; 39(9):1229-37. PMID: 16214038.
      View in: PubMed
    64. Tsai AG, Cabrales P, Johnson PC, Intaglietta M, Golub AS, Pittman RN. Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1777; author reply H1778-9. PMID: 16162870.
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    65. Cabrales P, Tsai AG, Winslow RM, Intaglietta M. Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2392-400. PMID: 16024576.
      View in: PubMed
    66. Tsai AG, Cabrales P, Intaglietta M. Blood viscosity: a factor in tissue survival? Crit Care Med. 2005 Jul; 33(7):1662-3. PMID: 16003089.
      View in: PubMed
    67. Cabrales P, Nacharaju P, Manjula BN, Tsai AG, Acharya SA, Intaglietta M. Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders. Shock. 2005 Jul; 24(1):66-73. PMID: 15988323.
      View in: PubMed
    68. Cabrales P, Intaglietta M, Tsai AG. Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding. Shock. 2005 Jun; 23(6):549-55. PMID: 15897809.
      View in: PubMed
    69. Johnson PC, Vandegriff K, Tsai AG, Intaglietta M. Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle. J Appl Physiol (1985). 2005 Apr; 98(4):1177-84. PMID: 15772057.
      View in: PubMed
    70. Manjula BN, Tsai AG, Intaglietta M, Tsai CH, Ho C, Smith PK, Perumalsamy K, Kanika ND, Friedman JM, Acharya SA. Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function. Protein J. 2005 Apr; 24(3):133-46. PMID: 16096719.
      View in: PubMed
    71. Sakai H, Cabrales P, Tsai AG, Tsuchida E, Intaglietta M. Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2897-903. PMID: 15681705.
      View in: PubMed
    72. Cabrales P, Tsai AG, Winslow RM, Intaglietta M. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2146-53. PMID: 15637119.
      View in: PubMed
    73. Acharya SA, Friedman JM, Manjula BN, Intaglietta M, Tsai AG, Winslow RM, Malavalli A, Vandegriff K, Smith PK. Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive. Artif Cells Blood Substit Immobil Biotechnol. 2005; 33(3):239-55. PMID: 16152690.
      View in: PubMed
    74. Cabrales P, Tsai AG, Intaglietta M. Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1708-16. PMID: 15591096.
      View in: PubMed
    75. Tsai AG, Acero C, Nance PR, Cabrales P, Frangos JA, Buerk DG, Intaglietta M. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1730-9. PMID: 15576432.
      View in: PubMed
    76. Tsai AG, Cabrales P, Hangai-Hoger N, Intaglietta M. Oxygen distribution and respiration by the microcirculation. Antioxid Redox Signal. 2004 Dec; 6(6):1011-8. PMID: 15548898.
      View in: PubMed
    77. Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M. Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1885-92. PMID: 15563528.
      View in: PubMed
    78. Hangai-Hoger N, Tsai AG, Friesenecker B, Cabrales P, Intaglietta M. Microvascular oxygen delivery and consumption following treatment with verapamil. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1515-20. PMID: 15563532.
      View in: PubMed
    79. Tsai AG, Cabrales P, Intaglietta M. Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions. Transfusion. 2004 Nov; 44(11):1626-34. PMID: 15504169.
      View in: PubMed
    80. Cabrales P, Tsai AG, Intaglietta M. Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock. Shock. 2004 Nov; 22(5):431-7. PMID: 15489635.
      View in: PubMed
    81. Wettstein R, Cabrales P, Erni D, Tsai AG, Winslow RM, Intaglietta M. Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin. Shock. 2004 Oct; 22(4):351-7. PMID: 15377891.
      View in: PubMed
    82. Manjula BN, Tsai AG, Intaglietta M, Tsai CH, Ho C, Malavalli A, Vandegriff KD, Winslow RM, Smith PK, Perumalsamy K, Devi Kanika N, Friedman JM, Acharya SA. WITHDRAWN: PEGylated hemoglobin: Role of surface configuration of PEG for the modulation of hemoglobin vasoactivity. J Biol Chem. 2004 Aug 27. PMID: 15194702.
      View in: PubMed
    83. Cabrales P, Tsai AG, Intaglietta M. Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2825-33. PMID: 15297257.
      View in: PubMed
    84. Tsai AG, Cabrales P, Intaglietta M. Oxygen-carrying blood substitutes: a microvascular perspective. Expert Opin Biol Ther. 2004 Jul; 4(7):1147-57. PMID: 15268681.
      View in: PubMed
    85. Cabrales P, Tsai AG, Frangos JA, Briceño JC, Intaglietta M. Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H320-30. PMID: 15210452.
      View in: PubMed
    86. Cabrales P, Kanika ND, Manjula BN, Tsai AG, Acharya SA, Intaglietta M. Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1609-17. PMID: 15191899.
      View in: PubMed
    87. Wettstein R, Tsai AG, Erni D, Lukyanov AN, Torchilin VP, Intaglietta M. Improving microcirculation is more effective than substitution of red blood cells to correct metabolic disorder in experimental hemorrhagic shock. Shock. 2004 Mar; 21(3):235-40. PMID: 14770036.
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    88. Cabrales P, Tsai AG, Intaglietta M. Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H363-73. PMID: 14975932.
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    89. Hangai-Hoger N, Cabrales P, Briceño JC, Tsai AG, Intaglietta M. Microlymphatic and tissue oxygen tension in the rat mesentery. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H878-83. PMID: 14630627.
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    90. Briceño JC, Cabrales P, Tsai AG, Intaglietta M. Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1223-8. PMID: 14615279.
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    91. Saldívar E, Cabrales P, Tsai AG, Intaglietta M. Microcirculatory changes during chronic adaptation to hypoxia. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H2064-71. PMID: 14561680.
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    92. Cabrales P, Acero C, Intaglietta M, Tsai AG. Measurement of the cardiac output in small animals by thermodilution. Microvasc Res. 2003 Sep; 66(2):77-82. PMID: 12935765.
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    93. Saltzman DJ, Toth A, Tsai AG, Intaglietta M, Johnson PC. Oxygen tension distribution in postcapillary venules in resting skeletal muscle. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H1980-5. PMID: 12842813.
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    94. Tsai AG, Johnson PC, Intaglietta M. Oxygen gradients in the microcirculation. Physiol Rev. 2003 Jul; 83(3):933-63. PMID: 12843412.
      View in: PubMed
    95. Tsai AG, Vandegriff KD, Intaglietta M, Winslow RM. Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics. Am J Physiol Heart Circ Physiol. 2003 Oct; 285(4):H1411-9. PMID: 12805024.
      View in: PubMed
    96. Tsai AG, Cabrales P, Winslow RM, Intaglietta M. Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia. Am J Physiol Heart Circ Physiol. 2003 Oct; 285(4):H1537-45. PMID: 12805029.
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    102. Tsai AG, Intaglietta M. The unusual properties of effective blood substitutes. Keio J Med. 2002 Mar; 51(1):17-20. PMID: 11951374.
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    103. Mazzoni MC, Tsai AG, Intaglietta M. Blood and plasma viscosity and microvascular function in hemodilution. A perspective from La Jolla, California. Eur Surg Res. 2002 Jan-Apr; 34(1-2):101-5. PMID: 11867909.
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    105. Tsai AG, Intaglietta M. High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger. Biorheology. 2001; 38(2-3):229-37. PMID: 11381177.
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