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    Amnon Altman

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0912
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pedros C, Zhang Y, Hu JK, Choi YS, Canonigo-Balancio AJ, Yates JR, Altman A, Crotty S, Kong KF. A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1. Nat Immunol. 2016 Jul; 17(7):825-33. PMID: 27135603.
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      2. Côte M, Fos C, Canonigo-Balancio AJ, Ley K, Bécart S, Altman A. SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1. J Cell Sci. 2015 Dec 1; 128(23):4341-52. PMID: 26483383.
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      3. Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y. TCR-induced sumoylation of the kinase PKC-? controls T cell synapse organization and T cell activation. Nat Immunol. 2015 Nov; 16(11):1195-203. PMID: 26390157.
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      4. Fos C, Becart S, Canonigo Balancio AJ, Boehning D, Altman A. Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP3 receptor 1 promotes Ca²? signaling in T cells. Sci Signal. 2014 Sep 30; 7(345):ra93. PMID: 25270259; PMCID: PMC4300114.
      5. Altman A, Kong KF. Protein kinase C inhibitors for immune disorders. Drug Discov Today. 2014 Aug; 19(8):1217-21. PMID: 24892801; PMCID: PMC4138286.
      6. Kong KF, Fu G, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio AJ, Becart S, Kim G, Yates JR, Kronenberg M, Saito T, Gascoigne NR, Altman A. Protein kinase C-? controls CTLA-4-mediated regulatory T cell function. Nat Immunol. 2014 May; 15(5):465-72. PMID: 24705298; PMCID: PMC4040250.
      7. Xie JJ, Liang JQ, Diao LH, Altman A, Li Y. TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol. 2013 Apr 15; 190(8):4027-36. PMID: 23514740; PMCID: PMC3622165.
      8. Kong KF, Altman A. In and out of the bull's eye: protein kinase Cs in the immunological synapse. Trends Immunol. 2013 May; 34(5):234-42. PMID: 23428395; PMCID: PMC3647024.
      9. Zhang EY, Kong KF, Altman A. The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression. Adv Pharmacol. 2013; 66:267-312. PMID: 23433459; PMCID: PMC3903317.
      10. Feau S, Schoenberger SP, Altman A, Bécart S. SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner. J Immunol. 2013 Jan 1; 190(1):174-83. PMID: 23197258.
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      11. Stahelin RV, Kong KF, Raha S, Tian W, Melowic HR, Ward KE, Murray D, Altman A, Cho W. Protein kinase C? C2 domain is a phosphotyrosine binding module that plays a key role in its activation. J Biol Chem. 2012 Aug 31; 287(36):30518-28. PMID: 22787157; PMCID: PMC3436300.
      12. Altman A, Kong KF. PKC?: a new target for selective immunosuppression. Expert Rev Clin Immunol. 2012 Mar; 8(3):205-8. PMID: 22390482.
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      13. Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C. Itk controls the spatiotemporal organization of T cell activation. Sci Signal. 2011 Oct 04; 4(193):ra66. PMID: 21971040; PMCID: PMC3248797.
      14. Kong KF, Yokosuka T, Canonigo-Balancio AJ, Isakov N, Saito T, Altman A. A motif in the V3 domain of the kinase PKC-? determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat Immunol. 2011 Oct 02; 12(11):1105-12. PMID: 21964608; PMCID: PMC3197934.
      15. Altman A, Kong KF. To kill, you have to duck an HDAC. Nat Immunol. 2011 Apr; 12(4):279-81. PMID: 21423220.
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      16. So T, Soroosh P, Eun SY, Altman A, Croft M. Antigen-independent signalosome of CARMA1, PKC?, and TNF receptor-associated factor 2 (TRAF2) determines NF-?B signaling in T cells. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2903-8. PMID: 21282629.
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      17. Ladygina N, Martin BR, Altman A. Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy. Adv Immunol. 2011; 109:1-44. PMID: 21569911.
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      18. Ohayon A, Babichev Y, Pasvolsky R, Dong G, Sztarkier I, Benharroch D, Altman A, Isakov N. Hodgkin's lymphoma cells exhibit high expression levels of the PICOT protein. J Immunotoxicol. 2010 Mar; 7(1):8-14. PMID: 20170406.
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      19. Canonigo-Balancio AJ, Fos C, Prod'homme T, Bécart S, Altman A. SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis. J Immunol. 2009 Dec 01; 183(11):7259-67. PMID: 19915062; PMCID: PMC2821872.
      20. Altman A, Koretzky GA, Tsoukas CD. Navigating the leukocyte signaling maze guided by Ariadne's thread. Nat Immunol. 2009 Nov; 10(11):1134-6. PMID: 19841642.
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      21. Bécart S, Altman A. SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells. Immunol Rev. 2009 Nov; 232(1):319-33. PMID: 19909373; PMCID: PMC2801603.
      22. Hundt M, Harada Y, De Giorgio L, Tanimura N, Zhang W, Altman A. Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. J Immunol. 2009 Aug 01; 183(3):1685-94. PMID: 19592663; PMCID: PMC2782658.
      23. Cohen S, Braiman A, Shubinsky G, Ohayon A, Altman A, Isakov N. PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion. Biochem Biophys Res Commun. 2009 Jul 17; 385(1):22-7. PMID: 19433059.
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      24. Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM. Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. J Biol Chem. 2009 May 01; 284(18):11882-91. PMID: 19251698; PMCID: PMC2673257.
      25. Bécart S, Balancio AJ, Charvet C, Feau S, Sedwick CE, Altman A. Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation. Immunity. 2008 Nov 14; 29(5):704-19. PMID: 18976935; PMCID: PMC2825161.
      26. Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008 Sep 29; 205(10):2339-47. PMID: 18794338.
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      27. Bécart S, Charvet C, Canonigo Balancio AJ, De Trez C, Tanaka Y, Duan W, Ware C, Croft M, Altman A. SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling. J Clin Invest. 2007 Aug; 117(8):2164-75. PMID: 17657315.
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      28. Melowic HR, Stahelin RV, Blatner NR, Tian W, Hayashi K, Altman A, Cho W. Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta. J Biol Chem. 2007 Jul 20; 282(29):21467-76. PMID: 17548359.
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      29. Hayashi K, Altman A. Protein kinase C theta (PKCtheta): a key player in T cell life and death. Pharmacol Res. 2007 Jun; 55(6):537-44. PMID: 17544292; PMCID: PMC2045646.
      30. Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006 Oct 15; 177(8):5024-31. PMID: 17015685.
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      31. Hayashi K, Altman A. Filamin A is required for T cell activation mediated by protein kinase C-theta. J Immunol. 2006 Aug 01; 177(3):1721-8. PMID: 16849481.
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      32. Hundt M, Tabata H, Jeon MS, Hayashi K, Tanaka Y, Krishna R, De Giorgio L, Liu YC, Fukata M, Altman A. Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity. 2006 May; 24(5):513-22. PMID: 16713970.
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      33. Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Mol Cell Biol. 2006 Mar; 26(5):1806-16. PMID: 16479000.
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      34. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006 Mar; 4(3):648-55. PMID: 16460447.
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      35. So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A. 2006 Mar 7; 103(10):3740-5. PMID: 16501042.
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      36. Barouch-Bentov R, Altman A. Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology. Adv Exp Med Biol. 2006; 584:1-13. PMID: 16802595.
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      37. Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis. J Immunol. 2005 Dec 1; 175(11):7635-41. PMID: 16301673.
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      38. Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP, Altman A. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol. 2005 Oct 15; 175(8):5126-34. PMID: 16210616.
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      39. Tanaka Y, So T, Lebedeva S, Croft M, Altman A. Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. Blood. 2005 Aug 15; 106(4):1286-95. PMID: 15845902.
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      40. Giannoni F, Barnett J, Bi K, Samodal R, Lanza P, Marchese P, Billetta R, Vita R, Klein MR, Prakken B, Kwok WW, Sercarz E, Altman A, Albani S. Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane. J Immunol. 2005 Mar 15; 174(6):3204-11. PMID: 15749850.
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      41. Charvet C, Canonigo AJ, Billadeau DD, Altman A. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. J Biol Chem. 2005 Apr 15; 280(15):15289-99. PMID: 15708849.
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      42. Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. J Immunol. 2004 Nov 15; 173(10):6440-7. PMID: 15528385.
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      43. Li Y, Sedwick CE, Hu J, Altman A. Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation. J Biol Chem. 2005 Jan 14; 280(2):1217-23. PMID: 15536066.
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      44. Foucault I, Le Bras S, Charvet C, Moon C, Altman A, Deckert M. The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor. Blood. 2005 Feb 01; 105(3):1106-13. PMID: 15345594.
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      45. Altman A, Kaminski S, Busuttil V, Droin N, Hu J, Tadevosyan Y, Hipskind RA, Villalba M. Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway. Eur J Immunol. 2004 Jul; 34(7):2001-11. PMID: 15214048.
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      46. Sedwick CE, Altman A. Perspectives on PKCtheta in T cell activation. Mol Immunol. 2004 Jul; 41(6-7):675-86. PMID: 15220003.
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      47. Srivastava KK, Batra S, Sassano A, Li Y, Majchrzak B, Kiyokawa H, Altman A, Fish EN, Platanias LC. Engagement of protein kinase C-theta in interferon signaling in T-cells. J Biol Chem. 2004 Jul 16; 279(29):29911-20. PMID: 15150272.
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      48. Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A. SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J. 2004 Mar 10; 23(5):1112-22. PMID: 14988727; PMCID: PMC380980.
      49. Altman A, Villalba M. Protein kinase C-theta (PKCtheta): it's all about location, location, location. Immunol Rev. 2003 Apr; 192:53-63. PMID: 12670395.
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      50. Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A. SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. Immunity. 2003 Mar; 18(3):403-14. PMID: 12648457.
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      51. del Pozo MA, Schwartz MA, Hu J, Kiosses WB, Altman A, Villalba M. Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading. J Immunol. 2003 Jan 01; 170(1):41-7. PMID: 12496381.
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      52. Altman A, Villalba M. Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death. J Biochem. 2002 Dec; 132(6):841-6. PMID: 12473184.
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      53. Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002 Sep 16; 21(18):4809-19. PMID: 12234921.
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      54. Villalba M, Altman A. Protein kinase C-theta (PKCtheta), a potential drug target for therapeutic intervention with human T cell leukemias. Curr Cancer Drug Targets. 2002 Jun; 2(2):125-37. PMID: 12188914.
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      55. Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 2002 Apr 15; 157(2):253-63. PMID: 11956228.
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      56. Kaminuma O, Elly C, Tanaka Y, Mori A, Liu YC, Altman A, Miyatake S. Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity. FEBS Lett. 2002 Mar 13; 514(2-3):153-8. PMID: 11943142.
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      57. Sedwick CE, Altman A. Ordered just so: lipid rafts and lymphocyte function. Sci STKE. 2002 Mar 05; 2002(122):re2. PMID: 11880687.
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      58. Fang N, Fang D, Wang HY, Altman A, Liu YC. Regulation of immune responses by E3 ubiquitin-protein ligases. Curr Dir Autoimmun. 2002; 5:161-75. PMID: 11826757.
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      59. Isakov N, Altman A. Protein kinase C(theta) in T cell activation. Annu Rev Immunol. 2002; 20:761-94. PMID: 11861617.
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      60. Junger WG, Hoyt DB, Davis RE, Herdon-Remelius C, Namiki S, Junger H, Loomis W, Altman A. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest. 1998 Jun 15; 101(12):2768-79. PMID: 9637711; PMCID: PMC508868.
      61. Junger WG, Coimbra R, Liu FC, Herdon-Remelius C, Junger W, Junger H, Loomis W, Hoyt DB, Altman A. Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock. 1997 Oct; 8(4):235-41. PMID: 9329123.
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      62. Junger WG, Hoyt DB, Hamreus M, Liu FC, Herdon-Remelius C, Junger W, Altman A. Hypertonic saline activates protein tyrosine kinases and mitogen-activated protein kinase p38 in T-cells. J Trauma. 1997 Mar; 42(3):437-43; discussion 443-5. PMID: 9095111.
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      63. Geng Y, Gulbins E, Altman A, Lotz M. Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8602-6. PMID: 8078929.
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