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Amnon Altman

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0912
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci Signal. 2016 09 13; 9(445):rs10. PMID: 27625306.
      View in: PubMed
    2. Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y. TCR-induced sumoylation of the kinase PKC-? controls T cell synapse organization and T cell activation. Nat Immunol. 2015 Nov; 16(11):1195-203. PMID: 26390157.
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    3. Kong KF, Fu G, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio AJ, Becart S, Kim G, Yates JR, Kronenberg M, Saito T, Gascoigne NR, Altman A. Protein kinase C-? controls CTLA-4-mediated regulatory T cell function. Nat Immunol. 2014 May; 15(5):465-72. PMID: 24705298; PMCID: PMC4040250.
    4. Kong KF, Altman A. In and out of the bull's eye: protein kinase Cs in the immunological synapse. Trends Immunol. 2013 May; 34(5):234-42. PMID: 23428395; PMCID: PMC3647024.
    5. Zhang EY, Kong KF, Altman A. The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression. Adv Pharmacol. 2013; 66:267-312. PMID: 23433459; PMCID: PMC3903317.
    6. Stahelin RV, Kong KF, Raha S, Tian W, Melowic HR, Ward KE, Murray D, Altman A, Cho W. Protein kinase C? C2 domain is a phosphotyrosine binding module that plays a key role in its activation. J Biol Chem. 2012 Aug 31; 287(36):30518-28. PMID: 22787157; PMCID: PMC3436300.
    7. Altman A, Kong KF. PKC?: a new target for selective immunosuppression. Expert Rev Clin Immunol. 2012 Mar; 8(3):205-8. PMID: 22390482.
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    8. Kong KF, Yokosuka T, Canonigo-Balancio AJ, Isakov N, Saito T, Altman A. A motif in the V3 domain of the kinase PKC-? determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat Immunol. 2011 Oct 02; 12(11):1105-12. PMID: 21964608; PMCID: PMC3197934.
    9. So T, Soroosh P, Eun SY, Altman A, Croft M. Antigen-independent signalosome of CARMA1, PKC?, and TNF receptor-associated factor 2 (TRAF2) determines NF-?B signaling in T cells. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2903-8. PMID: 21282629; PMCID: PMC3041086.
    10. Ohayon A, Golenser J, Sinay R, Tamir A, Altman A, Pollack Y, Isakov N. Protein kinase C ? deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria. Infect Immun. 2010 Oct; 78(10):4195-205. PMID: 20660606; PMCID: PMC2950346.
    11. Ohayon A, Babichev Y, Pasvolsky R, Dong G, Sztarkier I, Benharroch D, Altman A, Isakov N. Hodgkin's lymphoma cells exhibit high expression levels of the PICOT protein. J Immunotoxicol. 2010 Mar; 7(1):8-14. PMID: 20170406.
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    12. Hundt M, Harada Y, De Giorgio L, Tanimura N, Zhang W, Altman A. Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. J Immunol. 2009 Aug 01; 183(3):1685-94. PMID: 19592663; PMCID: PMC2782658.
    13. Cohen S, Braiman A, Shubinsky G, Ohayon A, Altman A, Isakov N. PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion. Biochem Biophys Res Commun. 2009 Jul 17; 385(1):22-7. PMID: 19433059.
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    14. Melowic HR, Stahelin RV, Blatner NR, Tian W, Hayashi K, Altman A, Cho W. Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta. J Biol Chem. 2007 Jul 20; 282(29):21467-76. PMID: 17548359.
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    15. Hayashi K, Altman A. Protein kinase C theta (PKCtheta): a key player in T cell life and death. Pharmacol Res. 2007 Jun; 55(6):537-44. PMID: 17544292; PMCID: PMC2045646.
    16. Hayashi K, Altman A. Filamin A is required for T cell activation mediated by protein kinase C-theta. J Immunol. 2006 Aug 01; 177(3):1721-8. PMID: 16849481.
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    17. Hundt M, Tabata H, Jeon MS, Hayashi K, Tanaka Y, Krishna R, De Giorgio L, Liu YC, Fukata M, Altman A. Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity. 2006 May; 24(5):513-22. PMID: 16713970.
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    18. Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Mol Cell Biol. 2006 Mar; 26(5):1806-16. PMID: 16479000; PMCID: PMC1430257.
    19. Barouch-Bentov R, Altman A. Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology. Adv Exp Med Biol. 2006; 584:1-13. PMID: 16802595.
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    20. Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis. J Immunol. 2005 Dec 01; 175(11):7635-41. PMID: 16301673.
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    21. Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP, Altman A. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol. 2005 Oct 15; 175(8):5126-34. PMID: 16210616.
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    22. Giannoni F, Barnett J, Bi K, Samodal R, Lanza P, Marchese P, Billetta R, Vita R, Klein MR, Prakken B, Kwok WW, Sercarz E, Altman A, Albani S. Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane. J Immunol. 2005 Mar 15; 174(6):3204-11. PMID: 15749850.
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    23. Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. J Immunol. 2004 Nov 15; 173(10):6440-7. PMID: 15528385.
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    24. Li Y, Sedwick CE, Hu J, Altman A. Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation. J Biol Chem. 2005 Jan 14; 280(2):1217-23. PMID: 15536066.
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    25. Sedwick CE, Altman A. Perspectives on PKCtheta in T cell activation. Mol Immunol. 2004 Jul; 41(6-7):675-86. PMID: 15220003.
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    26. Altman A, Kaminski S, Busuttil V, Droin N, Hu J, Tadevosyan Y, Hipskind RA, Villalba M. Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway. Eur J Immunol. 2004 Jul; 34(7):2001-11. PMID: 15214048.
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    27. Srivastava KK, Batra S, Sassano A, Li Y, Majchrzak B, Kiyokawa H, Altman A, Fish EN, Platanias LC. Engagement of protein kinase C-theta in interferon signaling in T-cells. J Biol Chem. 2004 Jul 16; 279(29):29911-20. PMID: 15150272.
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    28. Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A. SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J. 2004 Mar 10; 23(5):1112-22. PMID: 14988727; PMCID: PMC380980.
    29. Altman A, Villalba M. Protein kinase C-theta (PKCtheta): it's all about location, location, location. Immunol Rev. 2003 Apr; 192:53-63. PMID: 12670395.
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    30. Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A. SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. Immunity. 2003 Mar; 18(3):403-14. PMID: 12648457.
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    31. Altman A, Villalba M. Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death. J Biochem. 2002 Dec; 132(6):841-6. PMID: 12473184.
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    32. Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002 Sep 16; 21(18):4809-19. PMID: 12234921; PMCID: PMC126295.
    33. Villalba M, Altman A. Protein kinase C-theta (PKCtheta), a potential drug target for therapeutic intervention with human T cell leukemias. Curr Cancer Drug Targets. 2002 Jun; 2(2):125-37. PMID: 12188914.
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    34. Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 2002 Apr 15; 157(2):253-63. PMID: 11956228; PMCID: PMC2199257.
    35. Isakov N, Altman A. Protein kinase C(theta) in T cell activation. Annu Rev Immunol. 2002; 20:761-94. PMID: 11861617.
      View in: PubMed
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