Alexander Nott

Title(s)Assistant Project Scientist, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, CA, USAProject ScientistNeuroinflammation and epigenetics
    Massachusetts Institute of Technology, MA, USAPostdoctoral Fellow05/2016Neurodevelopmental Disorders
    University College London, London, UKPhD05/2011Neuroepigenetics
    University of Bath, Bath, UKMbiochem06/2005Biochemistry
    Collapse Awards and Honors
    Altman Clinical & Translational Research Institute - UCSD, CA2019  - 2022KL2 Career Development award (NIH)
    University of California, San Diego, CA2017  - 2020Alzheimer’s Association Research Fellowship Program
    Laboratory of Molecular and Cell Biology, UK2005  - 2009Medical Research Council (MRC) graduate funding
    University College London, UK2007Charlotte and Yule Bogue Research Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Alexi Nott received his undergraduate degree in Biochemistry at the University of Bath, UK. During his undergraduate studies he completed two internships on behavioral neuroscience and translational genomics at Duke University and Baylor College of Medicine, respectively. Alexi completed his PhD at the University College London on neuroepigenetics, where he elucidated the functional regulation of an epigenetic factor during neurodevelopment. Subsequently, Alexi completed his postdoctoral training at Massachusetts Institute of Technology on neurodevelopmental disorders, where he integrated mouse and human models to study Rett syndrome. Currently, Alexi is a Project Scientist at University of California, San Diego investigating the role of epigenetics of neurodegenerative disorders. His approach focuses on identifying cell type-specific gene regulatory mechanisms that are dysfunctional during aging-related brain diseases with a focus on neuroinflammation. Ultimately, Alexi aims to identify signaling pathways and epigenetic factors that drive brain diseases, to reveal new potential therapeutic targets and diagnostic biomarkers.

    Collapse Research 
    Collapse Research Activities and Funding
    Deciphering a functional role of genetic variation in Alzheimer’s disease
    KL2 Career Development Award (NIH/NCATS) KL2TR001444Aug 1, 2019 - Aug 31, 2022
    Role: Principle investigator
    Functional role of genetic variation in cell-specific pathogenesis of Alzheimer’s disease
    Alzheimer’s Association Research Fellowship AARF-18-531498Nov 1, 2017 - Nov 1, 2020
    Role: Principle investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    2. Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity. 2019 10 15; 51(4):655-670.e8. Sakai M, Troutman TD, Seidman JS, Ouyang Z, Spann NJ, Abe Y, Ego KM, Bruni CM, Deng Z, Schlachetzki JCM, Nott A, Bennett H, Chang J, Vu BT, Pasillas MP, Link VM, Texari L, Heinz S, Thompson BM, McDonald JG, Geissmann F, Glass CK. PMID: 31587991.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    3. Immune memory in the brain. Nature. 2018 04; 556(7701):312-313. Nott A, Glass CK. PMID: 29662132.
      View in: PubMed   Mentions:    Fields:    
    4. A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 11 01; 17(6):1683-1698. Nitarska J, Smith JG, Sherlock WT, Hillege MM, Nott A, Barshop WD, Vashisht AA, Wohlschlegel JA, Mitter R, Riccio A. PMID: 27806305.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    5. Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nat Neurosci. 2016 11; 19(11):1477-1488. Durak O, Gao F, Kaeser-Woo YJ, Rueda R, Martorell AJ, Nott A, Liu CY, Watson LA, Tsai LH. PMID: 27694995.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    6. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nat Neurosci. 2016 11; 19(11):1497-1505. Nott A, Cheng J, Gao F, Lin YT, Gjoneska E, Ko T, Minhas P, Zamudio AV, Meng J, Zhang F, Jin P, Tsai LH. PMID: 27428650.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    7. S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4152-7. Seneviratne U, Nott A, Bhat VB, Ravindra KC, Wishnok JS, Tsai LH, Tannenbaum SR. PMID: 27035958.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    8. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell. 2015 Jun 18; 161(7):1592-605. Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. PMID: 26052046.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    9. HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. Neuroepigenetics. 2015 Jan 01; 1:34-40. Nott A, Cho S, Seo J, Tsai LH. PMID: 25705589.
      View in: PubMed   Mentions:
    10. The Top3ß way to untangle RNA. Nat Neurosci. 2013 Sep; 16(9):1163-4. Nott A, Tsai LH. PMID: 23982446.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3113-8. Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A. PMID: 23359715.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    12. Nitric oxide-mediated epigenetic mechanisms in developing neurons. . 2009 Mar 01; 8(5):725-30. Nott A, Riccio A. PMID: 19221483.
      View in: PubMed   Mentions:
    13. S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature. 2008 Sep 18; 455(7211):411-5. Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A. PMID: 18754010.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    14. Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. Brain Res. 2006 Apr 07; 1081(1):72-8. Nott A, Levin ED. PMID: 16556437.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals