Alexander Nott

Title(s)Assistant Project Scientist, Cellular and Molecular Medicine
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, CA, USAProject ScientistNeuroinflammation and epigenetics
    Massachusetts Institute of Technology, MA, USAPostdoctoral Fellow05/2016Neurodevelopmental Disorders
    University College London, London, UKPhD05/2011Neuroepigenetics
    University of Bath, Bath, UKMbiochem06/2005Biochemistry
    Collapse Awards and Honors
    Altman Clinical & Translational Research Institute - UCSD, CA2019  - 2022KL2 Career Development award (NIH)
    University of California, San Diego, CA2017  - 2020Alzheimer’s Association Research Fellowship Program
    Laboratory of Molecular and Cell Biology, UK2005  - 2009Medical Research Council (MRC) graduate funding
    University College London, UK2007Charlotte and Yule Bogue Research Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Alexi Nott received his undergraduate degree in Biochemistry at the University of Bath, UK. During his undergraduate studies he completed two internships on behavioral neuroscience and translational genomics at Duke University and Baylor College of Medicine, respectively. Alexi completed his PhD at the University College London on neuroepigenetics, where he elucidated the functional regulation of an epigenetic factor during neurodevelopment. Subsequently, Alexi completed his postdoctoral training at Massachusetts Institute of Technology on neurodevelopmental disorders, where he integrated mouse and human models to study Rett syndrome. Currently, Alexi is a Project Scientist at University of California, San Diego investigating the role of epigenetics of neurodegenerative disorders. His approach focuses on identifying cell type-specific gene regulatory mechanisms that are dysfunctional during aging-related brain diseases with a focus on neuroinflammation. Ultimately, Alexi aims to identify signaling pathways and epigenetic factors that drive brain diseases, to reveal new potential therapeutic targets and diagnostic biomarkers.

    Collapse Research 
    Collapse Research Activities and Funding
    Deciphering a functional role of genetic variation in Alzheimer’s disease
    KL2 Career Development Award (NIH/NCATS) KL2TR001444Aug 1, 2019 - Aug 31, 2022
    Role: Principle investigator
    Functional role of genetic variation in cell-specific pathogenesis of Alzheimer’s disease
    Alzheimer’s Association Research Fellowship AARF-18-531498Nov 1, 2017 - Nov 1, 2020
    Role: Principle investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nott A, Glass CK. Immune memory in the brain. Nature. 2018 04; 556(7701):312-313. PMID: 29662132.
      View in: PubMed
    2. Nitarska J, Smith JG, Sherlock WT, Hillege MM, Nott A, Barshop WD, Vashisht AA, Wohlschlegel JA, Mitter R, Riccio A. A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 11 01; 17(6):1683-1698. PMID: 27806305.
      View in: PubMed
    3. Durak O, Gao F, Kaeser-Woo YJ, Rueda R, Martorell AJ, Nott A, Liu CY, Watson LA, Tsai LH. Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nat Neurosci. 2016 11; 19(11):1477-1488. PMID: 27694995.
      View in: PubMed
    4. Nott A, Cheng J, Gao F, Lin YT, Gjoneska E, Ko T, Minhas P, Zamudio AV, Meng J, Zhang F, Jin P, Tsai LH. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nat Neurosci. 2016 11; 19(11):1497-1505. PMID: 27428650.
      View in: PubMed
    5. Seneviratne U, Nott A, Bhat VB, Ravindra KC, Wishnok JS, Tsai LH, Tannenbaum SR. S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4152-7. PMID: 27035958.
      View in: PubMed
    6. Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell. 2015 Jun 18; 161(7):1592-605. PMID: 26052046.
      View in: PubMed
    7. Nott A, Cho S, Seo J, Tsai LH. HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. Neuroepigenetics. 2015 Jan 01; 1:34-40. PMID: 25705589.
      View in: PubMed
    8. Nott A, Tsai LH. The Top3ß way to untangle RNA. Nat Neurosci. 2013 Sep; 16(9):1163-4. PMID: 23982446.
      View in: PubMed
    9. Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A. S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3113-8. PMID: 23359715.
      View in: PubMed
    10. Nott A, Riccio A. Nitric oxide-mediated epigenetic mechanisms in developing neurons. Cell Cycle. 2009 Mar 01; 8(5):725-30. PMID: 19221483.
      View in: PubMed
    11. Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A. S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature. 2008 Sep 18; 455(7211):411-5. PMID: 18754010.
      View in: PubMed
    12. Nott A, Levin ED. Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. Brain Res. 2006 Apr 07; 1081(1):72-8. PMID: 16556437.
      View in: PubMed