Susan Kaech

Title(s)Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic heterogeneity of tissue resident memory T cells in the liver
    NIH R21AI151562Mar 6, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Metabolic regulation of epigenetic states in CD8 T cell exhaustion
    NIH R21AI151986Mar 5, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity
    NIH R01CA240909Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Understanding and Overcoming Resistance to Cancer Immunotherapy Due to Defective Antigen Presentation
    NIH R01CA230275Feb 6, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    (PQ5) Mitochondrial Heterogeneity in Melanoma Tumor and Immune Responses
    NIH R01CA216101Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    (PQ1) Lipid Metabolism, Inflammation, and T cell Dysfunction in HIV-associated Cancer
    NIH R01CA206483Jun 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Discovery of NR4A1/2 ligands controlling tissue-resident memory T (Trm) cells
    NIH R21AI131015Jan 1, 2017 - Dec 31, 2019
    Role: Co-Principal Investigator
    Cellular Mechanisms of Viral Control
    NIH R01AI123864Mar 15, 2016 - Feb 28, 2021
    Role: Co-Principal Investigator
    Targeting the Immune System in Mouse Models of Lung Adenocarcinoma
    NIH R01CA195720Apr 16, 2015 - Mar 31, 2018
    Role: Co-Principal Investigator
    The role of STAT3 in effector and memory CD8 T cell longevity and metabolism
    NIH R21AI097767Feb 1, 2012 - Jan 31, 2015
    Role: Principal Investigator
    iCyt Reflection Cell Sorter
    NIH S10RR029602Dec 10, 2009 - Dec 9, 2011
    Role: Principal Investigator
    Transcriptional control of IL-7 receptor (IL-7R) in T cells
    NIH R03TW008208Aug 10, 2009 - May 31, 2013
    Role: Principal Investigator
    Control of Effector and Memory T Cell Development by Inflammatory Signals
    NIH R01AI074699Jun 25, 2009 - May 31, 2015
    Role: Principal Investigator
    Determining how adjuvants alter effector and memory T cells during vaccination
    NIH R21AI081150May 22, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Control of Terminal Differentiation of Effector and Memory T Cells by Blimp-1
    NIH R21AI077075Aug 15, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH R37AI066232May 1, 2005 - Jan 31, 2023
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH R01AI066232May 1, 2005 - Oct 31, 2013
    Role: Principal Investigator
    Priming of Memory and Effector CD4 T Cells
    NIH R01CA038350Mar 1, 1984 - Dec 31, 2009
    Role: Principal Investigator
    Salk Institute Cancer Training Grant
    NIH T32CA009370Sep 1, 1980 - Jun 30, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth. Cancer Discov. 2024 Jan 25; OF1-OF22. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. PMID: 38270272.
      View in: PubMed   Mentions:    Fields:    
    2. EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. Cancer Discov. 2024 Jan 19. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteiza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. PMID: 38241033.
      View in: PubMed   Mentions:    Fields:    
    3. Early Chromatin Remodeling Events in Acutely Stimulated CD8+ T Cells. Yale J Biol Med. 2023 Dec; 96(4):467-473. McDonald B, Chick BY, Hargreaves DC, Kaech SM. PMID: 38161581; PMCID: PMC10751865.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Multiomics atlas-assisted discovery of transcription factors enables specific cell state programming. bioRxiv. 2023 Dec 05. Chung HK, Liu C, Sun M, Casillas E, Chen T, Chick B, Wang J, Ma S, Mcdonald B, He P, Yang Q, Varanasi SK, Mann T, Chen D, Hoffmann F, Tripple V, Hang Y, Ho J, Cho UH, Williams A, Wang Y, Hargreaves D, Kaech SM, Wang W. PMID: 36711632; PMCID: PMC9881845.
      View in: PubMed   Mentions:
    5. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. Mol Cancer. 2023 11 14; 22(1):182. Djureinovic D, Weiss SA, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto AL, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech SM, Bosenberg M, Jilaveanu LB, Kluger HM. PMID: 37964379; PMCID: PMC10644655.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. CD8+ T cells in the cancer-immunity cycle. Immunity. 2023 10 10; 56(10):2231-2253. Giles JR, Globig AM, Kaech SM, Wherry EJ. PMID: 37820583.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    7. Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance. Cancer Immunol Res. 2023 10 04; 11(10):1332-1350. Krykbaeva I, Bridges K, Damsky W, Pizzurro GA, Alexander AF, McGeary MK, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss SA, Olino K, Kaech SM, Kluger HM, Miller-Jensen K, Bosenberg M. PMID: 37478171.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science. 2023 09 22; 381(6664):1316-1323. Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. PMID: 37733872.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. 2023 Oct; 622(7982):383-392. Globig AM, Zhao S, Roginsky J, Maltez VI, Guiza J, Avina-Ochoa N, Heeg M, Araujo Hoffmann F, Chaudhary O, Wang J, Senturk G, Chen D, O'Connor C, Pfaff S, Germain RN, Schalper KA, Emu B, Kaech SM. PMID: 37731001; PMCID: PMC10871066.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Memory T Cells in the Immunoprevention of Cancer: A Switch from Therapeutic to Prophylactic Approaches. J Immunol. 2023 09 15; 211(6):907-916. Mittra S, Harding SM, Kaech SM. PMID: 37669503; PMCID: PMC10491418.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma. Immunity. 2023 09 12; 56(9):2086-2104.e8. Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O'Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM. PMID: 37572655.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates. Immunity. 2023 06 13; 56(6):1303-1319.e5. McDonald B, Chick BY, Ahmed NS, Burns M, Ma S, Casillas E, Chen D, Mann TH, O'Connor C, Hah N, Hargreaves DC, Kaech SM. PMID: 37315534; PMCID: PMC10281564.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Setdb1 -loss induces type-I interferons and immune clearance of melanoma. bioRxiv. 2023 May 24. McGeary MK, Damsky W, Daniels A, Song E, Micevic G, Huet-Calderwood C, Lou HJ, Paradkar S, Kaech S, Calderwood DA, Turk BE, Iwasaki A, Bosenberg MW. PMID: 37292991; PMCID: PMC10245815.
      View in: PubMed   Mentions:
    14. EGFR + lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. bioRxiv. 2023 Apr 17. Kuhlmann-Hogan A, Cordes T, Xu Z, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy SR, Nobari M, Cheng GZ, Shaw R, Leibel SL, Metallo CM, Politi K, Kaech SM. PMID: 37131637; PMCID: PMC10153136.
      View in: PubMed   Mentions:
    15. Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. Ann N Y Acad Sci. 2023 05; 1523(1):38-50. Cable J, Rathmell JC, Pearce EL, Ho PC, Haigis MC, Mamedov MR, Wu MJ, Kaech SM, Lynch L, Febbraio MA, Bapat SP, Hong HS, Zou W, Belkaid Y, Sullivan ZA, Keller A, Wculek SK, Green DR, Postic C, Amit I, Benitah SA, Jones RG, Reina-Campos M, Torres SV, Beyaz S, Brennan D, O'Neill LAJ, Perry RJ, Brenner D. PMID: 36960914; PMCID: PMC10367315.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Immunoediting instructs tumor metabolic reprogramming to support immune evasion. Cell Metab. 2023 01 03; 35(1):118-133.e7. Tsai CH, Chuang YM, Li X, Yu YR, Tzeng SF, Teoh ST, Lindblad KE, Di Matteo M, Cheng WC, Hsueh PC, Kao KC, Imrichova H, Duan L, Gallart-Ayala H, Hsiao PW, Mazzone M, Ivanesevic J, Liu X, de Visser KE, Lujambio A, Lunt SY, Kaech SM, Ho PC. PMID: 36599297; PMCID: PMC10375941.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection. J Exp Med. 2023 01 02; 220(1). Kasmani MY, Zander R, Chung HK, Chen Y, Khatun A, Damo M, Topchyan P, Johnson KE, Levashova D, Burns R, Lorenz UM, Tarakanova VL, Joshi NS, Kaech SM, Cui W. PMID: 36315049; PMCID: PMC9623343.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    18. SnapShot: Cancer immunoediting. Cell. 2022 Oct 13; 185(21):4038-4038.e1. Varanasi SK, Kaech SM, Bui JD. PMID: 36240741.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs. Elife. 2022 08 09; 11. Chandiran K, Suarez-Ramirez JE, Hu Y, Jellison ER, Ugur Z, Low JS, McDonald B, Kaech SM, Cauley LS. PMID: 35942952; PMCID: PMC9402230.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Eicosanoids in the pancreatic tumor microenvironment - a multicellular, multifaceted progression. Gastro Hep Adv. 2022; 1(4):682-697. Gubbala VB, Jytosana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han H, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, DelGiorno KE. PMID: 36277993; PMCID: PMC9583893.
      View in: PubMed   Mentions: 1  
    21. Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis. J Immunother Cancer. 2022 04; 10(4). Chaudhary O, Trotta D, Wang K, Wang X, Chu X, Bradley C, Okulicz J, Maves RC, Kronmann K, Schofield CM, Blaylock JM, Deng Y, Schalper KA, Kaech SM, Agan B, Ganesan A, Emu B. PMID: 35470232; PMCID: PMC9039380.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. Dev Cell. 2021 11 22; 56(22):3128-3145.e15. Wang T, Wang Z, de Fabritus L, Tao J, Saied EM, Lee HJ, Ramazanov BR, Jackson B, Burkhardt D, Parker M, Gleinich AS, Wang Z, Seo DE, Zhou T, Xu S, Alecu I, Azadi P, Arenz C, Hornemann T, Krishnaswamy S, van de Pavert SA, Kaech SM, Ivanova NB, Santori FR. PMID: 34762852; PMCID: PMC8628544.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    23. Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma. Dis Model Mech. 2021 11 01; 14(11). Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K. PMID: 34494649; PMCID: PMC8617309.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. Counting on You: How MHC Tetramers Revolutionized the Study of T Cell Memory and CD8+ T Cell Exhaustion. J Immunol. 2021 09 01; 207(5):1225-1227. Mann TH, Kaech SM. PMID: 34426517.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    25. Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet. Semin Immunol. 2021 02; 52:101485. Zhao S, Peralta RM, Avina-Ochoa N, Delgoffe GM, Kaech SM. PMID: 34462190; PMCID: PMC8545851.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis. Cell Rep. 2021 08 24; 36(8):109602. Qian Y, Arellano G, Ifergan I, Lin J, Snowden C, Kim T, Thomas JJ, Law C, Guan T, Balabanov RD, Kaech SM, Miller SD, Choi J. PMID: 34433042; PMCID: PMC8431781.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Motility Matters: How CD8+ T-Cell Trafficking Influences Effector and Memory Cell Differentiation. Cold Spring Harb Perspect Biol. 2021 08 02; 13(8). Farsakoglu Y, McDonald B, Kaech SM. PMID: 34001529; PMCID: PMC8327832.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. Parallels Between the Antiviral State and the Irradiated State. J Natl Cancer Inst. 2021 08 02; 113(8):969-979. McGee HM, Marciscano AE, Campbell AM, Monjazeb AM, Kaech SM, Teijaro JR. PMID: 33252657; PMCID: PMC8502484.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. A Phase I Study of APX005M and Cabiralizumab with or without Nivolumab in Patients with Melanoma, Kidney Cancer, or Non-Small Cell Lung Cancer Resistant to Anti-PD-1/PD-L1. Clin Cancer Res. 2021 09 01; 27(17):4757-4767. Weiss SA, Djureinovic D, Jessel S, Krykbaeva I, Zhang L, Jilaveanu L, Ralabate A, Johnson B, Levit NS, Anderson G, Zelterman D, Wei W, Mahajan A, Trifan O, Bosenberg M, Kaech SM, Perry CJ, Damsky W, Gettinger S, Sznol M, Hurwitz M, Kluger HM. PMID: 34140403; PMCID: PMC9236708.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    30. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021 07 13; 54(7):1561-1577.e7. Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. PMID: 34102100; PMCID: PMC9273026.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    31. How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications. Trends Immunol. 2021 05; 42(5):401-417. Van Acker HH, Ma S, Scolaro T, Kaech SM, Mazzone M. PMID: 33867272; PMCID: PMC9681987.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    32. The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates. J Exp Med. 2021 04 05; 218(4). Chung HK, McDonald B, Kaech SM. PMID: 33755719; PMCID: PMC7992501.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    33. Immigration in science. J Exp Med. 2020 11 02; 217(11). Casanova JL, Holtzman DM, Kaech SM, Lanier LL, Nathan CF, Rudensky AY, Tuveson D, Wolchok JD. PMID: 33057576; PMCID: PMC7563685.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. J Exp Med. 2020 08 03; 217(8). Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. PMID: 32525985; PMCID: PMC7398161.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    35. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 11; 159(5):1866-1881.e8. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. PMID: 32717220; PMCID: PMC7680354.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    36. Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Cancer Res. 2020 05 15; 80(10):2017-2030. Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech SM, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DAE, Politi K. PMID: 32193290; PMCID: PMC7392201.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    37. JEM women in STEM: Unique journeys with a common purpose. J Exp Med. 2020 03 02; 217(3). O'Garra A, Belkaid Y, Sharpe A, Kaech S, Cherry S, Passegué E. PMID: 33002100; PMCID: PMC7062526.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. J Immunol. 2020 03 15; 204(6):1661-1673. Avey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. PMID: 32060136; PMCID: PMC7755271.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsPHPublic Health
    39. Reinvigorating NIH Grant Peer Review. Immunity. 2020 01 14; 52(1):1-3. Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ, Once-a-Year Pledge Supporters. PMID: 31940266.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. Nat Metab. 2019 12; 1(12):1209-1218. Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. PMID: 32395698; PMCID: PMC7213273.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    41. T Cell Metabolism in a State of Flux. Immunity. 2019 11 19; 51(5):783-785. Varanasi SK, Ma S, Kaech SM. PMID: 31747577.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    42. O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth. Oncogene. 2020 01; 39(3):560-573. Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR, Han W, Sherwin RS, Nie Y, Yang X. PMID: 31501520; PMCID: PMC7107572.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    43. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell. 2019 09 19; 179(1):236-250.e18. Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, Yanovich-Arad G, Barnabas GD, Ashkenazi S, Besser MJ, Schachter J, Bosenberg M, Shadel GS, Barshack I, Kaech SM, Markel G, Geiger T. PMID: 31495571; PMCID: PMC7993352.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    44. Tick-TOX, it's time for T cell exhaustion. Nat Immunol. 2019 09; 20(9):1092-1094. Mann TH, Kaech SM. PMID: 31427776.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    45. The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment. Oncotarget. 2019 Jul 16; 10(44):4532-4545. Gaffney SG, Perry EB, Chen PM, Greenstein A, Kaech SM, Townsend JP. PMID: 31360302; PMCID: PMC6642048.
      View in: PubMed   Mentions: 7     Fields:    
    46. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. J Immunother Cancer. 2019 07 10; 7(1):172. Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. PMID: 31291990; PMCID: PMC6617639.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    47. A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression. Nat Commun. 2019 02 15; 10(1):794. Myers LM, Tal MC, Torrez Dulgeroff LB, Carmody AB, Messer RJ, Gulati G, Yiu YY, Staron MM, Angel CL, Sinha R, Markovic M, Pham EA, Fram B, Ahmed A, Newman AM, Glenn JS, Davis MM, Kaech SM, Weissman IL, Hasenkrug KJ. PMID: 30770827; PMCID: PMC6377614.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    48. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018 10 30; 25(5):1204-1213.e4. Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA. PMID: 30380412; PMCID: PMC6289175.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    49. T-bet in Tfh cells: Now you see me, now you don't. J Exp Med. 2018 11 05; 215(11):2697-2698. Kaech SM. PMID: 30337467; PMCID: PMC6219747.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    50. A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. Nat Commun. 2018 08 10; 9(1):3196. Gettinger SN, Choi J, Mani N, Sanmamed MF, Datar I, Sowell R, Du VY, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, Zhao H, Schlessinger J, Lifton R, Rimm DL, Chen L, Herbst RS, Schalper KA. PMID: 30097571; PMCID: PMC6086912.
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    51. Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. J Immunol. 2018 08 01; 201(3):908-915. Arojo OA, Ouyang X, Liu D, Meng T, Kaech SM, Pereira JP, Su B. PMID: 29934471.
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    52. Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response. Oncotarget. 2018 May 25; 9(40):25808-25825. Pereira FV, Melo ACL, Low JS, de Castro ÍA, Braga TT, Almeida DC, Batista de Lima AGU, Hiyane MI, Correa-Costa M, Andrade-Oliveira V, Origassa CST, Pereira RM, Kaech SM, Rodrigues EG, Câmara NOS. PMID: 29899823; PMCID: PMC5995253.
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    54. Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer. J Thorac Oncol. 2018 06; 13(6):831-839. Gettinger SN, Wurtz A, Goldberg SB, Rimm D, Schalper K, Kaech S, Kavathas P, Chiang A, Lilenbaum R, Zelterman D, Politi K, Herbst RS. PMID: 29578107; PMCID: PMC6485248.
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    55. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J Exp Med. 2018 04 02; 215(4):1153-1168. Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM. PMID: 29449309; PMCID: PMC5881466.
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    56. Correction: STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 03 05; 215(3):999. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. PMID: 29440270; PMCID: PMC5839754.
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    58. Trials and Tribble-ations of tissue TRM cells. Nat Immunol. 2018 02; 19(2):102-103. Low JS, Kaech SM. PMID: 29348504; PMCID: PMC6392028.
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    60. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci Immunol. 2017 10 20; 2(16). Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. PMID: 29054998; PMCID: PMC5846620.
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    61. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017 12; 7(12):1420-1435. Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K. PMID: 29025772; PMCID: PMC5718941.
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    62. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. Sci Rep. 2017 09 11; 7(1):11155. Yeon SM, Halim L, Chandele A, Perry CJ, Kim SH, Kim SU, Byun Y, Yuk SH, Kaech SM, Jung YW. PMID: 28894184; PMCID: PMC5593957.
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    63. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. PLoS Pathog. 2017 Aug; 13(8):e1006544. Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. PMID: 28827827; PMCID: PMC5578684.
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    64. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol. 2017 08 15; 199(4):1250-1260. Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. PMID: 28701508; PMCID: PMC5544928.
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    65. UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell Melanoma Res. 2017 07; 30(4):428-435. Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. PMID: 28379630; PMCID: PMC5820096.
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    68. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency. Immunity. 2017 04 18; 46(4):596-608. Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM. PMID: 28410989; PMCID: PMC5457165.
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    69. TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. Cancer. 2017 05 15; 123(10):1778-1790. Hajek M, Sewell A, Kaech S, Burtness B, Yarbrough WG, Issaeva N. PMID: 28295222; PMCID: PMC5419871.
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    71. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci Immunol. 2016 Oct; 1(5). Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. PMID: 28713870; PMCID: PMC5509416.
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    75. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016 08 01; 6:30636. Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. PMID: 27477778; PMCID: PMC4967920.
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    81. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20; 43(4):690-702. Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. PMID: 26410627; PMCID: PMC4618086.
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    82. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10; 162(6):1217-28. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. PMID: 26321681; PMCID: PMC4567953.
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    86. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015 Feb 12; 160(4):745-758. Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. PMID: 25662011; PMCID: PMC4498261.
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    87. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015 Apr 23; 520(7548):553-7. West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. PMID: 25642965; PMCID: PMC4409480.
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    90. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY). 2015 Jan; 7(1):38-52. Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. PMID: 25596819; PMCID: PMC4356402.
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    94. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity. 2014 Oct 16; 41(4):633-45. Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. PMID: 25308332; PMCID: PMC4324721.
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    96. CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest. 2014 Oct; 124(10):4549-63. Shaw PJ, Weidinger C, Vaeth M, Luethy K, Kaech SM, Feske S. PMID: 25157823; PMCID: PMC4191007.
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    97. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. PMID: 25082897; PMCID: PMC4143044.
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    98. Regulating the diverse outcomes of interferon's interference. Trends Immunol. 2014 Aug; 35(8):353-4. Marshall HD, Kaech SM. PMID: 25052591; PMCID: PMC4267687.
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    100. BRAF-targeted therapy alters the functions of intratumoral CD4+ T cells to inhibit melanoma progression. Oncoimmunology. 2014; 3:e29126. Ho PC, Kaech SM. PMID: 25083331; PMCID: PMC4106160.
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    105. Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity. 2013 Nov 14; 39(5):939-48. Slütter B, Pewe LL, Kaech SM, Harty JT. PMID: 24238342; PMCID: PMC3872058.
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    112. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 2012 Jun; 33(19):4957-64. Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM. PMID: 22484047; PMCID: PMC5724530.
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    113. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1210-5. Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS. PMID: 22167808; PMCID: PMC3268324.
      View in: PubMed   Mentions: 168     Fields:    Translation:AnimalsCells
    114. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 2011 Nov 23; 35(5):792-805. Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. PMID: 22118527; PMCID: PMC3431922.
      View in: PubMed   Mentions: 237     Fields:    Translation:AnimalsCells
    115. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity. 2011 Oct 28; 35(4):633-46. Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. PMID: 22018471; PMCID: PMC3444169.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    116. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J Immunol. 2011 Oct 15; 187(8):4068-76. Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, Kaech SM. PMID: 21930973; PMCID: PMC3991478.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    117. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood. 2011 Nov 24; 118(22):5965-76. Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. PMID: 21917752; PMCID: PMC3228506.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    118. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol. 2011 Jun; 178(6):2740-51. D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS. PMID: 21641396; PMCID: PMC3124231.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    119. IL-7 knocks the socs off chronic viral infection. Cell. 2011 Feb 18; 144(4):467-8. Parish IA, Kaech SM. PMID: 21335230; PMCID: PMC4380280.
      View in: PubMed   Mentions: 2     Fields:    
    120. Expression of kinesin superfamily genes in cultured hippocampal neurons. Cytoskeleton (Hoboken). 2010 Dec; 67(12):784-95. Silverman MA, Kaech S, Ramser EM, Lu X, Lasarev MR, Nagalla S, Banker G. PMID: 20862690; PMCID: PMC2996887.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    121. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol. 2010 Nov 01; 185(9):5315-25. Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM. PMID: 20921525; PMCID: PMC4267692.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    122. Like parent, like child: inheritance of effector CD8+ T cell traits. Immunity. 2010 Sep 24; 33(3):296-8. Jung YW, Kaech SM. PMID: 20870171.
      View in: PubMed   Mentions:    Fields:    
    123. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16601-6. Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM. PMID: 20823247; PMCID: PMC2944719.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    124. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol. 2010 Sep 01; 185(5):2989-97. Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. PMID: 20660705; PMCID: PMC3753007.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    125. Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev. 2010 Jul; 236:151-66. Cui W, Kaech SM. PMID: 20636815; PMCID: PMC4380273.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    126. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 2010 Jul 01; 185(1):313-26. Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. PMID: 20519643; PMCID: PMC2891136.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    127. Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation. Immunol Rev. 2010 May; 235(1):219-33. Rutishauser RL, Kaech SM. PMID: 20536566.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    128. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2010 May 15; 184(10):5723-31. Hinson ER, Joshi NS, Chen JH, Rahner C, Jung YW, Wang X, Kaech SM, Cresswell P. PMID: 20410488; PMCID: PMC3883313.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    129. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity. 2009 Aug 21; 31(2):296-308. Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Meffre E, Jacob J, Calame K, Kaech SM. PMID: 19664941; PMCID: PMC2783637.
      View in: PubMed   Mentions: 346     Fields:    Translation:AnimalsCells
    130. Diversity in CD8(+) T cell differentiation. Curr Opin Immunol. 2009 Jun; 21(3):291-7. Parish IA, Kaech SM. PMID: 19497720; PMCID: PMC3991474.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    131. Requirement of B cells for generating CD4+ T cell memory. J Immunol. 2009 Feb 15; 182(4):1868-76. Whitmire JK, Asano MS, Kaech SM, Sarkar S, Hannum LG, Shlomchik MJ, Ahmed R. PMID: 19201839; PMCID: PMC2658628.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    132. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine. 2009 Mar 26; 27(15):2177-87. Cui W, Joshi NS, Jiang A, Kaech SM. PMID: 19201385; PMCID: PMC2803112.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    133. Intrinsic and extrinsic control of effector T cell survival and memory T cell development. Immunol Res. 2009; 45(1):46-61. Hand TW, Kaech SM. PMID: 18629449.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    134. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol. 2008 Sep 15; 181(6):3804-10. Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA. PMID: 18768833; PMCID: PMC2835404.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    135. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 01; 181(3):1859-68. Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR. PMID: 18641323; PMCID: PMC3771862.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    136. Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol. 2008 Apr 15; 180(8):5309-19. Chandele A, Joshi NS, Zhu J, Paul WE, Leonard WJ, Kaech SM. PMID: 18390712; PMCID: PMC2792750.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    137. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. J Immunol. 2008 Feb 01; 180(3):1309-15. Joshi NS, Kaech SM. PMID: 18209024.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    138. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007 Oct; 27(4):670-84. Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R. PMID: 17950003.
      View in: PubMed   Mentions: 1159     Fields:    Translation:AnimalsCells
    139. Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity. 2007 Sep; 27(3):393-405. Kaech SM, Wherry EJ. PMID: 17892848; PMCID: PMC3431921.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansAnimalsCells
    140. Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. Mitochondrion. 2007 Dec; 7(6):374-85. D'Souza AD, Parikh N, Kaech SM, Shadel GS. PMID: 17890163; PMCID: PMC2692272.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    141. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug; 27(2):281-95. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM. PMID: 17723218; PMCID: PMC2034442.
      View in: PubMed   Mentions: 1051     Fields:    Translation:AnimalsCells
    142. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11730-5. Hand TW, Morre M, Kaech SM. PMID: 17609371; PMCID: PMC1913873.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    143. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006 Dec; 5(6):473-86. Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR. PMID: 17129212.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    144. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005 Dec; 6(12):1236-44. Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, Goldrath AW, Ahmed R, Reiner SL. PMID: 16273099.
      View in: PubMed   Mentions: 693     Fields:    Translation:HumansAnimalsCells
    145. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol. 2005 Nov 01; 175(9):5783-9. Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z. PMID: 16237070.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    146. Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. J Immunol. 2005 Nov 01; 175(9):5619-23. Chandele A, Kaech SM. PMID: 16237050; PMCID: PMC3245648.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    147. Differentiation of CD8 T cells in response to acute and chronic viral infections: implications for HIV vaccine development. Curr Drug Targets Infect Disord. 2005 Jun; 5(2):121-9. Miller JD, Masopust D, Wherry EJ, Kaech S, Silvestri G, Ahmed R. PMID: 15975018.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    148. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7418-25. Manders PM, Hunter PJ, Telaranta AI, Carr JM, Marshall JL, Carrasco M, Murakami Y, Palmowski MJ, Cerundolo V, Kaech SM, Ahmed R, Fearon DT. PMID: 15833813; PMCID: PMC1140431.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    149. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. J Immunol. 2005 Mar 01; 174(5):2900-9. Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, Silvestri G. PMID: 15728501.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    150. The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis. J Immunol. 2004 Nov 01; 173(9):5425-33. Sabbagh L, Kaech SM, Bourbonnière M, Woo M, Cohen LY, Haddad EK, Labrecque N, Ahmed R, Sékaly RP. PMID: 15494489.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    151. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16004-9. Wherry EJ, Barber DL, Kaech SM, Blattman JN, Ahmed R. PMID: 15505208; PMCID: PMC524220.
      View in: PubMed   Mentions: 249     Fields:    Translation:AnimalsCells
    152. Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells. J Virol. 2004 Oct; 78(20):10953-9. Latner DR, Kaech SM, Ahmed R. PMID: 15452215; PMCID: PMC521836.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    153. The role of programming in memory T-cell development. Curr Opin Immunol. 2004 Apr; 16(2):217-25. Masopust D, Kaech SM, Wherry EJ, Ahmed R. PMID: 15023416.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    154. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol. 2003 Dec; 4(12):1191-8. Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. PMID: 14625547.
      View in: PubMed   Mentions: 911     Fields:    Translation:AnimalsCells
    155. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology. 2003 Sep; 110(1):10-7. Wan J, Martinvalet D, Ji X, Lois C, Kaech SM, Von Andrian UH, Lieberman J, Ahmed R, Manjunath N. PMID: 12941136; PMCID: PMC1783016.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    156. TCR signal transduction in antigen-specific memory CD8 T cells. J Immunol. 2003 Jun 01; 170(11):5455-63. Kersh EN, Kaech SM, Onami TM, Moran M, Wherry EJ, Miceli MC, Ahmed R. PMID: 12759421.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    157. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest. 2003 Jun; 111(12):1887-95. Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R, Larsen CP. PMID: 12813024; PMCID: PMC161424.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansAnimalsCells
    158. Models of CD8+ responses: 1. What is the antigen-independent proliferation program. J Theor Biol. 2003 Apr 21; 221(4):585-98. Antia R, Bergstrom CT, Pilyugin SS, Kaech SM, Ahmed R. PMID: 12713942.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    159. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med. 2003 May; 9(5):540-7. Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. PMID: 12692546.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    160. Immunology. CD8 T cells remember with a little help. Science. 2003 Apr 11; 300(5617):263-5. Kaech SM, Ahmed R. PMID: 12690179.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    161. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003 Mar; 4(3):225-34. Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R. PMID: 12563257.
      View in: PubMed   Mentions: 801     Fields:    Translation:AnimalsCells
    162. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol. 2003 Feb 01; 170(3):1443-51. Shen H, Whitmire JK, Fan X, Shedlock DJ, Kaech SM, Ahmed R. PMID: 12538706.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    163. Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. J Immunol. 2003 Jan 01; 170(1):147-52. Hathcock KS, Kaech SM, Ahmed R, Hodes RJ. PMID: 12496394.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    164. Molecular and functional profiling of memory CD8 T cell differentiation. Cell. 2002 Dec 13; 111(6):837-51. Kaech SM, Hemby S, Kersh E, Ahmed R. PMID: 12526810.
      View in: PubMed   Mentions: 423     Fields:    Translation:AnimalsCells
    165. Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol. 2002 Apr; 2(4):251-62. Kaech SM, Wherry EJ, Ahmed R. PMID: 12001996.
      View in: PubMed   Mentions: 678     Fields:    Translation:HumansAnimalsCells
    166. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med. 2002 Mar 04; 195(5):657-64. Blattman JN, Antia R, Sourdive DJ, Wang X, Kaech SM, Murali-Krishna K, Altman JD, Ahmed R. PMID: 11877489; PMCID: PMC2193761.
      View in: PubMed   Mentions: 245     Fields:    Translation:AnimalsCells
    167. Cytoskeletal microdifferentiation: a mechanism for organizing morphological plasticity in dendrites. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7086-92. Kaech S, Parmar H, Roelandse M, Bornmann C, Matus A. PMID: 11416192; PMCID: PMC34627.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    168. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol. 2001 May; 2(5):415-22. Kaech SM, Ahmed R. PMID: 11323695; PMCID: PMC3760150.
      View in: PubMed   Mentions: 460     Fields:    Translation:AnimalsCells
    169. Glutamate receptors regulate actin-based plasticity in dendritic spines. Nat Neurosci. 2000 Sep; 3(9):887-94. Fischer M, Kaech S, Wagner U, Brinkhaus H, Matus A. PMID: 10966619.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    170. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem. 1998 Nov 27; 273(48):31633-6. Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B. PMID: 9822620.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    171. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell. 1998 Sep 18; 94(6):761-71. Kaech SM, Whitfield CW, Kim SK. PMID: 9753323; PMCID: PMC3224769.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    172. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell. 1996 Apr 19; 85(2):195-204. Simske JS, Kaech SM, Harp SA, Kim SK. PMID: 8612272.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    173. Improved lipid-mediated gene transfer into primary cultures of hippocampal neurons. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):344-8. Kaech S, Kim JB, Cariola M, Ralston E. PMID: 8717375.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    174. Molecular characterization of a neuronal-specific protein that stimulates the activity of Cdk5. J Neurochem. 1995 May; 64(5):1988-95. Shetty KT, Kaech S, Link WT, Jaffe H, Flores CM, Wray S, Pant HC, Beushausen S. PMID: 7536802.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    175. Myristylation and amino-terminal phosphorylation are required for activation of pp60c-src during mitosis. Oncogene. 1993 Mar; 8(3):575-81. Kaech S, Schnierle B, Wyss A, Ballmer-Hofer K. PMID: 7679790.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    176. Association of p60c-src with polyoma virus middle-T antigen abrogating mitosis-specific activation. Nature. 1991 Apr 04; 350(6317):431-3. Kaech S, Covic L, Wyss A, Ballmer-Hofer K. PMID: 1707141.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    177. Myristylation of pp60c-src is not required for complex formation with polyomavirus middle-T antigen. J Virol. 1990 Oct; 64(10):5163-6. Wyss A, Kaech S, Ballmer-Hofer K. PMID: 2168992; PMCID: PMC248010.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    178. Stimulation of pp60c-src kinase activity in FDC-P1 cells by polyoma middle-T antigen and hematopoietic growth factors. Oncogene. 1989 Dec; 4(12):1433-9. Muser J, Kaech S, Moroni C, Ballmer-Hofer K. PMID: 2480561.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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