Ronald Evans

Title(s)Adjunct Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Engineering human islet-like organoids for transplantation
    NIH R01DK120480Sep 30, 2018 - Jul 31, 2022
    Role: Principal Investigator
    A Hub for the Nuclear Receptor Signaling Atlas1
    NIH U24DK097748Sep 17, 2012 - Aug 31, 2019
    Role: Principal Investigator
    Role of Immune Mechanisms in Athersclerosis and Inflammation
    NIH P01HL088093Apr 1, 2007 - Apr 30, 2020
    Role: Co-Investigator
    PPARs: Transcriptional Regulators of Metabolism
    NIH R13DK063898Jan 1, 2003 - Dec 31, 2003
    Role: Principal Investigator
    Nuclear Receptors and Coregulators in Health and Disease
    NIH U19DK062434Aug 15, 2002 - Jul 31, 2012
    Role: Co-Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NUCLEAR RECEPTORS 2000
    NIH R13DK057518Mar 20, 2000 - Feb 28, 2001
    Role: Principal Investigator
    SCOR in Molecular Medicine and Atherosclerosis
    NIH P50HL056989Apr 23, 1997 - Mar 31, 2008
    Role: Co-Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    Translational Cardiovascular Science and Medicine
    NIH T32HL007770Jul 1, 1993 - Dec 31, 2009
    Role: Principal Investigator
    Transcriptional Regulation of Cell Growth
    NIH P01CA054418Jun 1, 1991 - Apr 30, 2006
    Role: Co-Investigator
    Spatial Regulation of Developmental Gene Expression
    NIH R01HL105278Sep 12, 1990 - Sep 30, 2020
    Role: Principal Investigator
    Spatial Regulation of Developmental Gene Expression
    NIH R01HD027183Sep 12, 1990 - May 31, 2010
    Role: Principal Investigator
    GORDON RESEARCH CONFERENCE ON MOLECULAR GENETICS
    NIH R13HD027968Jul 20, 1990 - Jul 19, 1991
    Role: Principal Investigator
    A Laser Microbeam Biotechnology Resource
    NIH P41RR001192Dec 1, 1979 - Mar 31, 2013
    Role: Co-Investigator
    Hormonal Regulation of Mammalian Gene Expression
    NIH R01DK057978Apr 1, 1979 - Mar 31, 2025
    Role: Principal Investigator
    Hormonal Regulation of Mammalian Gene Expression
    NIH R37DK057978Apr 1, 1979 - Sep 30, 2020
    Role: Principal Investigator
    HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSION
    NIH R37GM026444Apr 1, 1979 - Mar 31, 2000
    Role: Principal Investigator
    HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSION
    NIH R01GM026444Apr 1, 1979 - Mar 31, 1990
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA014195Dec 1, 1977 - Jan 31, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting nuclear receptor corepressors for reversible male contraception. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2320129121. Hong SH, Castro G, Wang D, Nofsinger R, Kane M, Folias A, Atkins AR, Yu RT, Napoli JL, Sassone-Corsi P, de Rooij DG, Liddle C, Downes M, Evans RM. PMID: 38377195.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab. 2024 Feb; 6(2):273-289. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. PMID: 38286821; PMCID: PMC10896723.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proc Natl Acad Sci U S A. 2024 Jan 09; 121(2):e2316104121. Abe Y, Kofman ER, Ouyang Z, Cruz-Becerra G, Spann NJ, Seidman JS, Troutman TD, Stender JD, Taylor H, Fan W, Link VM, Shen Z, Sakai J, Downes M, Evans RM, Kadonaga JT, Rosenfeld MG, Glass CK. PMID: 38165941; PMCID: PMC10786282.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. Nat Commun. 2023 Dec 06; 14(1):7791. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 38057326; PMCID: PMC10700526.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. Circulation. 2024 Jan 16; 149(3):227-250. Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker JK, Jensen BC, Pei L, Burris T, Zhang L. PMID: 37961903; PMCID: PMC10842599.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023 10 05; 83(19):3421-3437.e11. Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. PMID: 37751740; PMCID: PMC10591845.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression. bioRxiv. 2023 Sep 14. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 37745372; PMCID: PMC10515810.
      View in: PubMed   Mentions:
    8. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. Cell Rep. 2023 08 29; 42(8):112997. Fu T, Huan T, Rahman G, Zhi H, Xu Z, Oh TG, Guo J, Coulter S, Tripathi A, Martino C, McCarville JL, Zhu Q, Cayabyab F, Low B, He M, Xing S, Vargas F, Yu RT, Atkins A, Liddle C, Ayres J, Raffatellu M, Dorrestein PC, Downes M, Knight R, Evans RM. PMID: 37611587; PMCID: PMC10903535.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Silver electroceutical technology to treat sarcopenia. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2300036120. Kim MY, Shin HY, Cho SC, Yang S, Intisar A, Woo HJ, Choi YS, You CL, Kang JS, Lee YI, Park SC, Yea K, Oh TG, Downes M, Evans RM, Kim MS. PMID: 37549292; PMCID: PMC10438839.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. Sci Total Environ. 2023 Nov 15; 899:165667. Kushwaha P, Tran A, Quintero D, Song M, Yu Q, Yu R, Downes M, Evans RM, Babst-Kostecka A, Schroeder JI, Maier RM. PMID: 37478925; PMCID: PMC10529914.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    12. PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2217826120. Yoon BK, Kim H, Oh TG, Oh SK, Jo S, Kim M, Chun KH, Hwang N, Lee S, Jin S, Atkins AR, Yu RT, Downes M, Kim JW, Kim H, Evans RM, Cheong JH, Fang S. PMID: 37192160; PMCID: PMC10214193.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 04 21; 18(4):756-771. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. PMID: 36988910.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Legacy: a tribute to Terri Grodzicker of Genes & Development. Genes Dev. 2023 Jan 01; 37(1-2):20-21. Evans RM. PMID: 37061954; PMCID: PMC10046438.
      View in: PubMed   Mentions:    Fields:    
    15. FXR mediates ILC-intrinsic responses to intestinal inflammation. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2213041119. Fu T, Li Y, Oh TG, Cayabyab F, He N, Tang Q, Coulter S, Truitt M, Medina P, He M, Yu RT, Atkins A, Zheng Y, Liddle C, Downes M, Evans RM. PMID: 36508655; PMCID: PMC9907109.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Autocrine FGF1 signaling promotes glucose uptake in adipocytes. Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2122382119. Nies VJM, Struik D, Liu S, Liu W, Kruit JK, Downes M, van Zutphen T, Verkade HJ, Evans RM, Jonker JW. PMID: 36161959; PMCID: PMC9546606.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. Aliment Pharmacol Ther. 2022 11; 56(10):1475-1485. Sharpton SR, Oh TG, Madamba E, Wang C, Yu RT, Atkins AR, Huan T, Downes M, Evans RM, Loomba R. PMID: 36164267; PMCID: PMC9746351.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6. Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    19. Shared Mechanisms between Cardiovascular Disease and NAFLD. Semin Liver Dis. 2022 Nov; 42(4):455-464. Huang DQ, Downes M, Evans RM, Witztum JL, Glass CK, Loomba R. PMID: 36008083.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Metabolic Messengers: fibroblast growth factor 1. Nat Metab. 2022 06; 4(6):663-671. Gasser E, Sancar G, Downes M, Evans RM. PMID: 35681108; PMCID: PMC9624216.
      View in: PubMed   Mentions: 3     Fields:    
    21. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. Mol Metab. 2022 07; 61:101504. Casanova-Vallve N, Duglan D, Vaughan ME, Pariollaud M, Handzlik MK, Fan W, Yu RT, Liddle C, Downes M, Delezie J, Mello R, Chan AB, Westermark PO, Metallo CM, Evans RM, Lamia KA. PMID: 35470095; PMCID: PMC9079800.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    22. Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    23. Interorgan crosstalk in pancreatic islet function and pathology. FEBS Lett. 2022 03; 596(5):607-619. Evans RM, Wei Z. PMID: 35014695; PMCID: PMC8930530.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest. 2022 01 18; 132(2). Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. PMID: 34847077; PMCID: PMC8759781.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    25. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ahmed NS, Gatchalian J, Ho J, Burns MJ, Hah N, Wei Z, Downes M, Evans RM, Hargreaves DC. PMID: 34983841; PMCID: PMC8740701.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. FGF1 and insulin control lipolysis by convergent pathways. Cell Metab. 2022 01 04; 34(1):171-183.e6. Sancar G, Liu S, Gasser E, Alvarez JG, Moutos C, Kim K, van Zutphen T, Wang Y, Huddy TF, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM. PMID: 34986332; PMCID: PMC8863067.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    27. Colon cancer checks in when bile acids check out: the bile acid-nuclear receptor axis in colon cancer. Essays Biochem. 2021 12 17; 65(6):1015-1024. Tang Q, Evans RM. PMID: 34414429; PMCID: PMC8628182.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
      View in: PubMed   Mentions: 1     Fields:    
    29. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature. 2021 11; 599(7884):296-301. Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. PMID: 34707293; PMCID: PMC9186421.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. J Biol Chem. 2021 11; 297(5):101173. Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Suyama K, Nose T, Yoshihara E, Downes M, Evans RM, Matsushima A. PMID: 34499926; PMCID: PMC8551653.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). Wang L, Oh TG, Magida J, Estepa G, Obayomi SMB, Chong LW, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. PMID: 34446564; PMCID: PMC8536317.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep. 2021 06 29; 35(13):109331. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. PMID: 34192547; PMCID: PMC8293281.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    33. Neural basis of opioid-induced respiratory depression and its rescue. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Liu S, Kim DI, Oh TG, Pao GM, Kim JH, Palmiter RD, Banghart MR, Lee KF, Evans RM, Han S. PMID: 34074761; PMCID: PMC8201770.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    34. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021 07 13; 54(7):1561-1577.e7. Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. PMID: 34102100; PMCID: PMC9273026.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    35. Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis. Cell Metab. 2021 03 02; 33(3):457. Oh TG, Kim SM, Atkins AR, Yu RT, Downes M, Evans RM, Loomba R. PMID: 33657386.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(1):293-320. Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. PMID: 33631374; PMCID: PMC8166943.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    37. Publisher Correction: Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2021 Feb; 590(7844):E27. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 33469222.
      View in: PubMed   Mentions:    Fields:    
    38. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis. 2020 Nov 09; 9(11):100. Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. PMID: 33168807; PMCID: PMC7653036.
      View in: PubMed   Mentions: 25  
    39. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):901. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 33147487; PMCID: PMC7891106.
      View in: PubMed   Mentions: 24     Fields:    
    40. Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. Cancer Res. 2020 10 15; 80(20):4324-4334. Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee JH, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. PMID: 32928922; PMCID: PMC7906529.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    41. Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing. Cell Metab. 2020 11 03; 32(5):704-709. Evans RM, Lippman SM. PMID: 32941797; PMCID: PMC7486067.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2020 10; 586(7830):606-611. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 32814902; PMCID: PMC7872080.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    43. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 11 03; 32(5):878-888.e6. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 32610095; PMCID: PMC7822714.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    44. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 07; 2(7):620-634. Reilly SM, Hung CW, Ahmadian M, Zhao P, Keinan O, Gomez AV, DeLuca JH, Dadpey B, Lu D, Zaid J, Poirier B, Peng X, Yu RT, Downes M, Liddle C, Evans RM, Murphy AN, Saltiel AR. PMID: 32694788; PMCID: PMC7384260.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    45. Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. Cell Metab. 2020 06 02; 31(6):1173-1188.e5. Paschoal VA, Walenta E, Talukdar S, Pessentheiner AR, Osborn O, Hah N, Chi TJ, Tye GL, Armando AM, Evans RM, Chi NW, Quehenberger O, Olefsky JM, Oh DY. PMID: 32413335; PMCID: PMC7337476.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    46. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. 2020 06 16; 52(6):1057-1074.e7. Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK. PMID: 32362324; PMCID: PMC7305990.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
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    234. Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. Toxicol Appl Pharmacol. 2005 Dec 01; 209(2):174-82. Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Evans RM, Sinclair JF. PMID: 15907335.
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    235. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol. 2005 Oct; 25(19):8456-64. Zhao X, Sternsdorf T, Bolger TA, Evans RM, Yao TP. PMID: 16166628; PMCID: PMC1265742.
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    236. Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005 Dec; 33(12):1827-36. Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF. PMID: 16141365.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    237. A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol. 2005 Oct; 19(10):2466-77. Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM. PMID: 16051664.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    238. A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol. 2005 Oct; 19(10):2437-50. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. PMID: 16051663.
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    239. The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. Mol Endocrinol. 2005 Oct; 19(10):2433-6. Margolis RN, Evans RM, O'Malley BW, NURSA Atlas Consortium. PMID: 16051673.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    240. The nuclear receptor superfamily: a rosetta stone for physiology. Mol Endocrinol. 2005 Jun; 19(6):1429-38. Evans RM. PMID: 15914712.
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    241. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2063-8. Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M. PMID: 15684063; PMCID: PMC548592.
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    242. Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2198-203. Sonoda J, Chong LW, Downes M, Barish GD, Coulter S, Liddle C, Lee CH, Evans RM. PMID: 15671183; PMCID: PMC548561.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    243. Development of ecdysone-regulated lentiviral vectors. Mol Ther. 2005 Jan; 11(1):142-8. Galimi F, Saez E, Gall J, Hoong N, Cho G, Evans RM, Verma IM. PMID: 15585415.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    244. Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. Mol Cell Biol. 2004 Dec; 24(24):10661-9. Shalom-Barak T, Nicholas JM, Wang Y, Zhang X, Ong ES, Young TH, Gendler SJ, Evans RM, Barak Y. PMID: 15572671; PMCID: PMC533980.
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    245. A nuclear strike against Listeria--the evolving life of LXR. Cell. 2004 Oct 15; 119(2):149-51. Barish GD, Evans RM. PMID: 15479632.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    246. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004 Nov; 10(11):1245-50. Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang Q. PMID: 15475963.
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    247. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem. 2004 Nov 19; 279(47):49517-22. Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. PMID: 15358766.
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    248. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004 Oct; 2(10):e294. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. PMID: 15328533; PMCID: PMC509410.
      View in: PubMed   Mentions: 438     Fields:    Translation:AnimalsCells
    249. 2003 Keio Medical Science Prize commemorative lecture. PPARs and the complex journey to obesity. Keio J Med. 2004 Jun; 53(2):53-8. Evans RM. PMID: 15264367.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    250. PPARs and LXRs: atherosclerosis goes nuclear. Trends Endocrinol Metab. 2004 May-Jun; 15(4):158-65. Barish GD, Evans RM. PMID: 15109614.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    251. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PMID: 15107844.
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    252. PPARs and the complex journey to obesity. Nat Med. 2004 Apr; 10(4):355-61. Evans RM, Barish GD, Wang YX. PMID: 15057233.
      View in: PubMed   Mentions: 603     Fields:    Translation:HumansCells
    253. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4047-52. Tsai CC, Kao HY, Mitzutani A, Banayo E, Rajan H, McKeown M, Evans RM. PMID: 15016912; PMCID: PMC384693.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    254. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem. 2004 May 21; 279(21):22250-7. Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. PMID: 15004017.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    255. PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev. 2004 Mar 01; 18(5):528-40. Saez E, Rosenfeld J, Livolsi A, Olson P, Lombardo E, Nelson M, Banayo E, Cardiff RD, Izpisua-Belmonte JC, Evans RM. PMID: 15037548; PMCID: PMC374235.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    256. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol. 2004 Feb; 65(2):292-300. Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. PMID: 14742670.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    257. A methylation-mediator complex in hormone signaling. Genes Dev. 2004 Jan 15; 18(2):144-56. Xu W, Cho H, Kadam S, Banayo EM, Anderson S, Yates JR, Emerson BM, Evans RM. PMID: 14729568; PMCID: PMC324421.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    258. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. PMID: 14702088.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
    259. Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci. 2004 Jan; 13(1):203-10. Demarest SJ, Deechongkit S, Dyson HJ, Evans RM, Wright PE. PMID: 14691235; PMCID: PMC2286511.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    260. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. PMID: 14660788; PMCID: PMC307633.
      View in: PubMed   Mentions: 449     Fields:    Translation:AnimalsCells
    261. Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. J Immunol. 2003 Dec 01; 171(11):5743-50. Natarajan C, Muthian G, Barak Y, Evans RM, Bright JJ. PMID: 14634082.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    262. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. PMID: 14625542.
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    263. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003 Oct 17; 302(5644):453-7. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK. PMID: 12970571.
      View in: PubMed   Mentions: 193     Fields:    Translation:AnimalsCells
    264. Genetic deficiency in Pparg does not alter development of experimental prostate cancer. Nat Med. 2003 Oct; 9(10):1265-6. Saez E, Olson P, Evans RM. PMID: 12960963.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    265. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology. 2003 Jun; 144(6):2201-7. Lee CH, Olson P, Evans RM. PMID: 12746275.
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    266. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 2003 Apr 18; 113(2):159-70. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM. PMID: 12705865.
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    267. Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol. 2003 Apr 04; 327(4):819-32. Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE. PMID: 12654265.
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    268. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. PMID: 12718892; PMCID: PMC6179153.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    269. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Mol Endocrinol. 2003 Jul; 17(7):1268-82. Rosenfeld JM, Vargas R, Xie W, Evans RM. PMID: 12663745.
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    270. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org Biomol Chem. 2003 Mar 21; 1(6):908-20. Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. PMID: 12929628.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    271. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4150-5. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. PMID: 12644700; PMCID: PMC153063.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    272. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. Miles PD, Barak Y, Evans RM, Olefsky JM. PMID: 12556354.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    273. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003 Mar; 130(6):1113-22. Stenman J, Yu RT, Evans RM, Campbell K. PMID: 12571103.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    274. PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1268-73. Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. PMID: 12540828; PMCID: PMC298762.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    275. Acetylation and methylation in nuclear receptor gene activation. Methods Enzymol. 2003; 364:205-23. Xu W, Cho H, Evans RM. PMID: 14631847.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    276. Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain. J Biol Chem. 2003 Feb 28; 278(9):7366-73. Kao HY, Han CC, Komar AA, Evans RM. PMID: 12468549.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    277. Peroxisome proliferator-activated receptor-gamma in macrophage lipid homeostasis. Trends Endocrinol Metab. 2002 Oct; 13(8):331-5. Lee CH, Evans RM. PMID: 12217489.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    278. Vitamin D receptor as an intestinal bile acid sensor. Science. 2002 May 17; 296(5571):1313-6. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. PMID: 12016314.
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    279. Pharmaceutical use of mouse models humanized for the xenobiotic receptor. Drug Discov Today. 2002 May 01; 7(9):509-15. Xie W, Evans RM. PMID: 11983567.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    280. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2613-8. Shi Y, Hon M, Evans RM. PMID: 11867749; PMCID: PMC122396.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    281. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002 Feb; 9(2):265-77. Tini M, Benecke A, Um SJ, Torchia J, Evans RM, Chambon P. PMID: 11864601.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    282. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):303-8. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. PMID: 11756685; PMCID: PMC117556.
      View in: PubMed   Mentions: 196     Fields:    Translation:Animals
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