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A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol. 2024 Feb 29.
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. PMID: 38424270.
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PubMed Mentions:
1 Fields:
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The Past and Future of Inflammation as a Target to Cancer Prevention. Cancer Prev Res (Phila). 2024 Jan 25.
Antonucci L, Karin M. PMID: 38271694.
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PubMed Mentions: Fields:
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Cholesterol esterification and p53-mediated tumor suppression. Explor Target Antitumor Ther. 2023; 4(5):1122-1127.
Li Y, Karin M, Prochownik EV. PMID: 38023993; PMCID: PMC10651352.
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IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance. Sci Adv. 2023 10 27; 9(43):eadg5391.
Rundberg Nilsson AJS, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 37889967; PMCID: PMC10610924.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Sci Adv. 2023 09 15; 9(37):eadh0831.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. PMID: 37703359; PMCID: PMC10499313.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Multifaceted collagen-DDR1 signaling in cancer. Trends Cell Biol. 2023 Sep 12.
Su H, Karin M. PMID: 37709651.
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PubMed Mentions: Fields:
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Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ Health Perspect. 2023 09; 131(9):97001.
Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S. PMID: 37668303; PMCID: PMC10478510.
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PubMed Mentions: Fields:
Translation:
Animals
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Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration. bioRxiv. 2023 Jul 21.
Fini MA, Monks JA, Li M, Gerasimovskaya E, Paucek P, Wang K, Frid MG, Pugliese SC, Bratton D, Yu YR, Irwin D, Karin M, Wright RM, Stenmark KR. PMID: 37502951; PMCID: PMC10370167.
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Author Correction: A central role for JNK in obesity and insulin resistance. Nature. 2023 Jul; 619(7968):E25.
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 37328696.
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PubMed Mentions: Fields:
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Collagen architecture and signaling orchestrate cancer development. Trends Cancer. 2023 09; 9(9):764-773.
Su H, Karin M. PMID: 37400314.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Signalling by senescent melanocytes hyperactivates hair growth. Nature. 2023 Jun; 618(7966):808-817.
Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. PMID: 37344645; PMCID: PMC10284692.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis. Nat Commun. 2023 05 08; 14(1):2651.
Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi HY, Shrestha R, Pan SQ, Chen Y, Li M, Kapelanski-Lamoureux A, Yochum G, Sher L, Monga SP, Lazaris A, Machida K, Karin M, Guccione E, Tsukamoto H. PMID: 37156770; PMCID: PMC10167314.
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AnimalsCells
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Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2300706120.
Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang JY, Pandit SK, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 37126700; PMCID: PMC10175751.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 05; 30(5):1097-1154.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. PMID: 37100955; PMCID: PMC10130819.
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36 Fields:
Translation:
HumansAnimals
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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
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HumansAnimals
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P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology. 2023 05 01; 77(5):1499-1511.
Zhu Y, Gu L, Lin X, Zhou X, Lu B, Liu C, Li Y, Prochownik EV, Karin M, Wang F, Li Y. PMID: 35398929.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential. Cell Genom. 2023 May 10; 3(5):100301.
Carlessi R, Denisenko E, Boslem E, Köhn-Gaone J, Main N, Abu Bakar NDB, Shirolkar GD, Jones M, Beasley AB, Poppe D, Dwyer BJ, Jackaman C, Tjiam MC, Lister R, Karin M, Fallowfield JA, Kendall TJ, Forbes SJ, Gray ES, Olynyk JK, Yeoh G, Forrest ARR, Ramm GA, Febbraio MA, Tirnitz-Parker JEE. PMID: 37228755; PMCID: PMC10203275.
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PubMed Mentions:
3
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ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol. 2023 08; 79(2):362-377.
He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. PMID: 36996941.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. bioRxiv. 2023 Mar 06.
Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang J, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 36945365; PMCID: PMC10028807.
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PubMed Mentions:
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IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance. bioRxiv. 2023 Mar 02.
Rundberg Nilsson A, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 36747722; PMCID: PMC9900858.
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PubMed Mentions:
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Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24.
Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
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Oxidized mitochondrial DNA: a protective signal gone awry. Trends Immunol. 2023 03; 44(3):188-200.
Xian H, Karin M. PMID: 36739208.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. 2022 11 15; 13(11):959.
Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, Shelanski ML, Bouaziz S, Karin M, El Amri C, Jacotot ED. PMID: 36379916; PMCID: PMC9666555.
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Translation:
HumansCells
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Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature. 2022 10; 610(7931):356-365.
Filliol A, Saito Y, Nair A, Dapito DH, Yu LX, Ravichandra A, Bhattacharjee S, Affo S, Fujiwara N, Su H, Sun Q, Savage TM, Wilson-Kanamori JR, Caviglia JM, Chin L, Chen D, Wang X, Caruso S, Kang JK, Amin AD, Wallace S, Dobie R, Yin D, Rodriguez-Fiallos OM, Yin C, Mehal A, Izar B, Friedman RA, Wells RG, Pajvani UB, Hoshida Y, Remotti HE, Arpaia N, Zucman-Rossi J, Karin M, Henderson NC, Tabas I, Schwabe RF. PMID: 36198802; PMCID: PMC9949942.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372.
Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6.
Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Semin Liver Dis. 2022 08; 42(3):233-249.
Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. PMID: 36001995; PMCID: PMC9662188.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 08 02; 34(8):1201-1213.e5.
Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. PMID: 35921818; PMCID: PMC9365100.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346.
Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8.
Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
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PubMed Mentions:
93 Fields:
Translation:
AnimalsCells
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Diabesity? No worries, FKBP11 to the rescue. Cell Metab. 2022 07 05; 34(7):942-944.
Karin M. PMID: 35793657.
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Translation:
AnimalsCells
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NF-κB: A Double-Edged Sword Controlling Inflammation. Biomedicines. 2022 May 27; 10(6).
Liu D, Zhong Z, Karin M. PMID: 35740272; PMCID: PMC9219609.
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PubMed Mentions:
19
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Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth. Cell Death Discov. 2022 Mar 03; 8(1):94.
De Marco M, Gauttier V, Pengam S, Mary C, Ranieri B, Basile A, Festa M, Falco A, Reppucci F, Cammarota AL, Acernese F, De Laurenzi V, Sala G, Brongo S, Miyasaka M, Shalapour S, Vanhove B, Poirier N, Iaccarino R, Karin M, Turco MC, Rosati A, Marzullo L. PMID: 35241649; PMCID: PMC8894496.
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PubMed Mentions:
2
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Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 01; 20(3):337-349.
Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. PMID: 34810213; PMCID: PMC8898265.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A. 2022 02 08; 119(6).
Song NY, Li X, Ma B, Willette-Brown J, Zhu F, Jiang C, Su L, Shetty J, Zhao Y, Shi G, Banerjee S, Wu X, Tran B, Nussinov R, Karin M, Hu Y. PMID: 35121655; PMCID: PMC8833198.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021 12 09; 12(1):7172.
Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. PMID: 34887405; PMCID: PMC8660815.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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"Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab. 2021 12 07; 33(12):2316-2328.
Febbraio MA, Karin M. PMID: 34619076; PMCID: PMC8665123.
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PubMed Mentions:
34 Fields:
Translation:
Humans
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Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18).
Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Regulation of antitumor immunity by inflammation-induced epigenetic alterations. Cell Mol Immunol. 2022 01; 19(1):59-66.
Karin M, Shalapour S. PMID: 34465885; PMCID: PMC8752743.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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The neglected brothers come of age: B cells and cancer. Semin Immunol. 2021 02; 52:101479.
Shalapour S, Karin M. PMID: 34215491; PMCID: PMC8545794.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Am J Pathol. 2021 09; 191(9):1564-1579.
Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. PMID: 34119473; PMCID: PMC8406794.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11.
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. PMID: 34115964; PMCID: PMC8189765.
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PubMed Mentions:
105 Fields:
Translation:
HumansAnimalsCells
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Macropinocytosis: the big drinker behind cancer cell self-consumption. Autophagy. 2021 05; 17(5):1290-1291.
Su H, Yang F, Sun B, Karin M. PMID: 33879021; PMCID: PMC8143249.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proc Natl Acad Sci U S A. 2021 04 13; 118(15).
Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. PMID: 33833060; PMCID: PMC8054017.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis. Cancers (Basel). 2021 Mar 25; 13(7).
Okuda K, Umemura A, Umemura S, Kataoka S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, Shima T, Okanoue T, Karin M, Itoh Y. PMID: 33806040; PMCID: PMC8037653.
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PubMed Mentions:
4
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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 2021 05 10; 39(5):678-693.e11.
Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. PMID: 33740421; PMCID: PMC8119368.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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From Liver Fat to Cancer: Perils of the Western Diet. Cancers (Basel). 2021 Mar 04; 13(5).
Kim JY, He F, Karin M. PMID: 33806428; PMCID: PMC7961422.
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PubMed Mentions:
9
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Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. Proc Natl Acad Sci U S A. 2021 02 23; 118(8).
Zhou Y, Bastian IN, Long MD, Dow M, Li W, Liu T, Ngu RK, Antonucci L, Huang JY, Phung QT, Zhao XH, Banerjee S, Lin XJ, Wang H, Dang B, Choi S, Karin D, Su H, Ellisman MH, Jamieson C, Bosenberg M, Cheng Z, Haybaeck J, Kenner L, Fisch KM, Bourgon R, Hernandez G, Lill JR, Liu S, Carter H, Mellman I, Karin M, Shalapour S. PMID: 33602823; PMCID: PMC7923353.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study. BMJ Open. 2021 02 12; 11(2):e043584.
Ebinger JE, Botwin GJ, Albert CM, Alotaibi M, Arditi M, Berg AH, Binek A, Botting P, Fert-Bober J, Figueiredo JC, Grein JD, Hasan W, Henglin M, Hussain SK, Jain M, Joung S, Karin M, Kim EH, Li D, Liu Y, Luong E, McGovern DPB, Merchant A, Merin N, Miles PB, Minissian M, Nguyen TT, Raedschelders K, Rashid MA, Riera CE, Riggs RV, Sharma S, Sternbach S, Sun N, Tourtellotte WG, Van Eyk JE, Sobhani K, Braun JG, Cheng S. PMID: 33579769; PMCID: PMC7883610.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021 06; 74(6):1429-1441.
Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC. PMID: 33515644; PMCID: PMC8573791.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 2021 05; 18(5):261-279.
Hou J, Karin M, Sun B. PMID: 33469195; PMCID: PMC8978805.
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PubMed Mentions:
91 Fields:
Translation:
Humans
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Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31259-31266.
Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553; PMCID: PMC7733785.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045.
Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 08 10; 38(2):247-262.e11.
Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943; PMCID: PMC7423690.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 06 17; 41(4):405-416.
He F, Antonucci L, Karin M. PMID: 32347301; PMCID: PMC7298623.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimals
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Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 05 28; 18(1):214.
Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781; PMCID: PMC7257145.
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Immunotherapy, Inflammation and Colorectal Cancer. Cells. 2020 03 04; 9(3).
Lichtenstern CR, Ngu RK, Shalapour S, Karin M. PMID: 32143413; PMCID: PMC7140520.
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PubMed Mentions:
116 Fields:
Translation:
HumansAnimals
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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020 03; 8(1).
Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM. PMID: 32209603; PMCID: PMC7064135.
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PubMed Mentions:
376 Fields:
Translation:
Humans
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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol. 2020 06; 72(6):1182-1195.
He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M. PMID: 32105670; PMCID: PMC8054878.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3).
Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annu Rev Immunol. 2020 04 26; 38:649-671.
Shalapour S, Karin M. PMID: 32040356; PMCID: PMC8936002.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660.
Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622; PMCID: PMC8012106.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 07; 27(7):2206-2216.
Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855; PMCID: PMC7308363.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 2020 05; 72(5):960-975.
Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. PMID: 31954207.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 01 13; 11(1):189.
Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P. PMID: 31929511; PMCID: PMC6955241.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 01 13; 11(1):190.
Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. PMID: 31929512; PMCID: PMC6955242.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. Cancer Cell. 2020 Jan 13; 37(1):135-136.
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 31935370.
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PubMed Mentions: Fields:
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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959.
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 Nov 15; 79(22):5897.
Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson L, Karasic T, Llovet J, Finn R, Groopman J, El-Serag H, Monga S, Wang XW, Karin M, Schwartz R, Tanabe K, Roberts L, Gunaratne P, Tsung A, Brown K, Lawrence T, Salem R, Singal A, Kim A, Rabiee A, Resar L, Meyer J, Hoshida Y, He AR, Ghoshal K, Ryan P, Jaffee E, Guha C, Mishra L, Coleman N, Ahmed M. PMID: 31772073.
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PubMed Mentions:
3 Fields:
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Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-κB kinase subunit β-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769.
Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063; PMCID: PMC6962627.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312.
Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566; PMCID: PMC6957844.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 09 01; 79(17):4326-4330.
Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. PMID: 31481419; PMCID: PMC8330805.
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PubMed Mentions:
67 Fields:
Translation:
Humans
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The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications. J Hepatol. 2020 01; 72(1):167-182.
Hou J, Zhang H, Sun B, Karin M. PMID: 31449859.
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PubMed Mentions:
77 Fields:
Translation:
HumansAnimals
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Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation. Immunity. 2019 07 16; 51(1):15-26.
Shalapour S, Karin M. PMID: 31315033; PMCID: PMC6640850.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimals
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The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 2019 05 13; 35(5):714-720.
Todoric J, Karin M. PMID: 31085174.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7.
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734; PMCID: PMC6675591.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach. Mol Cancer Res. 2019 07; 17(7):1493-1502.
Friemel J, Frick L, Unger K, Egger M, Parrotta R, Böge YT, Adili A, Karin M, Luedde T, Heikenwalder M, Weber A. PMID: 30967480.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470.
Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461; PMCID: PMC6461375.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785.
Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003; PMCID: PMC7133393.
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PubMed Mentions:
11 Fields:
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Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 2019 01 08; 29(1):18-26.
Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. PMID: 30449681; PMCID: PMC6326872.
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PubMed Mentions:
105 Fields:
Translation:
HumansAnimals
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NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6.
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007; PMCID: PMC6409207.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888.
Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485; PMCID: PMC6196518.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15.
Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454; PMCID: PMC6159928.
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PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200.
Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212; PMCID: PMC6166836.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714; PMCID: PMC7871211.
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PubMed Mentions:
1 Fields:
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203.
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112; PMCID: PMC6329306.
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PubMed Mentions:
441 Fields:
Translation:
AnimalsCells
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The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411.
Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586; PMCID: PMC6319369.
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PubMed Mentions:
491 Fields:
Translation:
Humans
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6.
Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692; PMCID: PMC6005359.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET. J Hepatol. 2018 07; 69(1):79-88.
Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. PMID: 29505847; PMCID: PMC6008184.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar; 25(3):486-541.
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479; PMCID: PMC5864239.
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PubMed Mentions:
2353 Fields:
Translation:
HumansAnimalsCells
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NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 05; 18(5):309-324.
Taniguchi K, Karin M. PMID: 29379212.
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PubMed Mentions:
1003 Fields:
Translation:
HumansAnimalsCells
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IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E812-E821.
Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. PMID: 29311298; PMCID: PMC5789942.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29168501; PMCID: PMC8594569.
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PubMed Mentions:
3 Fields:
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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. PMID: 29153842; PMCID: PMC5730340.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460; PMCID: PMC5884449.
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PubMed Mentions:
238 Fields:
Translation:
HumansAnimalsCells
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Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017; 12(8):e0181052.
Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. PMID: 28797077; PMCID: PMC5552280.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. 2017 10; 60(10):2021-2032.
Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A. PMID: 28725915.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 2017 Jul 19; 18(8):861-869.
Afonina IS, Zhong Z, Karin M, Beyaert R. PMID: 28722711.
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PubMed Mentions:
264 Fields:
Translation:
HumansCells
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DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7414-7419.
Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. PMID: 28652331; PMCID: PMC5514741.
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PubMed Mentions:
209 Fields:
Translation:
HumansCells
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GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017 05; 24(5):929-943.
Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. PMID: 28387757; PMCID: PMC5423119.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440.
Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773; PMCID: PMC5338369.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648.
Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. PMID: 28130546; PMCID: PMC5320959.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat Immunol. 2017 03; 18(3):354-363.
Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. PMID: 28114291; PMCID: PMC5321575.
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PubMed Mentions:
120 Fields:
Translation:
HumansAnimalsCells
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Corrigendum: PI3Kγ is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27974794.
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PubMed Mentions:
17 Fields:
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Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prev Res (Phila). 2016 Dec; 9(12):895-905.
Todoric J, Antonucci L, Karin M. PMID: 27913448; PMCID: PMC5142754.
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PubMed Mentions:
144 Fields:
Translation:
Humans
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Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18.
Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. PMID: 27814504; PMCID: PMC5908236.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 2016 Oct 20; 167(3):606-609.
Moscat J, Karin M, Diaz-Meco MT. PMID: 27768885; PMCID: PMC5114003.
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PubMed Mentions:
198 Fields:
Translation:
HumansCells
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p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer Cell. 2016 10 10; 30(4):595-609.
Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. PMID: 27728806; PMCID: PMC5081228.
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PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27642729; PMCID: PMC5479689.
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PubMed Mentions:
535 Fields:
Translation:
HumansAnimalsCells
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IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. Hepatology. 2016 10; 64(4):1217-31.
Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. PMID: 27396433.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 2016 08; 590(15):2375-97.
Taniguchi K, Yamachika S, He F, Karin M. PMID: 27404485; PMCID: PMC4983218.
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PubMed Mentions:
56 Fields:
Translation:
Humans
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Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 2016 Jul-Aug; 34(4 Suppl 98):12-6.
Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27586797.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14; 166(2):288-298.
Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27419869; PMCID: PMC4947210.
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PubMed Mentions:
288 Fields:
Translation:
HumansAnimals
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Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer. Cell Rep. 2016 06 28; 16(1):120-132.
McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS. PMID: 27320908; PMCID: PMC4927403.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal. 2016 06 07; 9(431):re5.
Lee JH, Cho US, Karin M. PMID: 27273098; PMCID: PMC4902175.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948.
Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 27211490; PMCID: PMC4907799.
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PubMed Mentions:
214 Fields:
Translation:
HumansAnimalsCells
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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 05 17; 7:11551.
de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. PMID: 27187615; PMCID: PMC4873670.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. Cell Metab. 2016 05 10; 23(5):759-61.
Shalapour S, Karin M. PMID: 27166937.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis. 2016 06; 37(6):541-6.
Karin M, Dhar D. PMID: 27207669; PMCID: PMC4876993.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimals
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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910.
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428; PMCID: PMC4769378.
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PubMed Mentions:
495 Fields:
Translation:
AnimalsCells
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The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35.
Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399; PMCID: PMC4878828.
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PubMed Mentions:
15
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Reparative inflammation takes charge of tissue regeneration. Nature. 2016 Jan 21; 529(7586):307-15.
Karin M, Clevers H. PMID: 26791721; PMCID: PMC5228603.
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PubMed Mentions:
332 Fields:
Translation:
HumansAnimalsCells
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Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling. J Immunol. 2016 Mar 01; 196(5):2368-76.
Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. PMID: 26792803; PMCID: PMC4761524.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Obesity and Cancer: The Oil that Feeds the Flame. Cell Metab. 2016 Jan 12; 23(1):48-62.
Font-Burgada J, Sun B, Karin M. PMID: 26771116.
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PubMed Mentions:
155 Fields:
Translation:
HumansAnimals
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Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14670-5.
Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K. PMID: 26554006; PMCID: PMC4664371.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun. 2015 Nov 02; 6:8695.
Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. PMID: 26522614; PMCID: PMC4659838.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6166-74.
Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M. PMID: 26512112; PMCID: PMC4653219.
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PubMed Mentions:
117 Fields:
Translation:
AnimalsCells
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Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015 Dec; 16(12):1235-44.
Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. PMID: 26502405; PMCID: PMC4653079.
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PubMed Mentions:
174 Fields:
Translation:
HumansAnimalsCells
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The IL-23 to IL-17 cascade inflammation-related cancers. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S87-90.
Wang K, Karin M. PMID: 26457610.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nat Commun. 2015 Oct 12; 6:8428.
Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. PMID: 26455434.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Sep 21; 5:14029.
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Hee Lee J. PMID: 26390293; PMCID: PMC4642703.
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PubMed Mentions:
3 Fields:
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Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. 2016 05 19; 35(20):2634-44.
Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. PMID: 26364612; PMCID: PMC4791217.
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PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
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Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015 Sep; 125(9):3347-55.
Shalapour S, Karin M. PMID: 26325032; PMCID: PMC4588298.
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PubMed Mentions:
352 Fields:
Translation:
HumansAnimalsCells
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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79.
Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631; PMCID: PMC4545590.
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PubMed Mentions:
237 Fields:
Translation:
AnimalsCells
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Immune Infiltration and Prostate Cancer. Front Oncol. 2015; 5:128.
Strasner A, Karin M. PMID: 26217583; PMCID: PMC4495337.
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PubMed Mentions:
99
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Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 2015 Jul; 266(1):161-74.
Wu X, Karin M. PMID: 26085214.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine Growth Factor Rev. 2015 Aug; 26(4):389-403.
Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP. PMID: 26119834; PMCID: PMC4526340.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimals
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A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84.
Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. PMID: 26109050; PMCID: PMC4495398.
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PubMed Mentions:
183 Fields:
Translation:
HumansAnimalsCells
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Tumor-Elicited Inflammation and Colorectal Cancer. Adv Cancer Res. 2015; 128:173-96.
Wang K, Karin M. PMID: 26216633.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimals
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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8.
Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. PMID: 25924065; PMCID: PMC4501632.
View in:
PubMed Mentions:
271 Fields:
Translation:
HumansAnimalsCells
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Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94.
Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. PMID: 25909884; PMCID: PMC4816107.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30; 5:9502.
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. PMID: 25819761; PMCID: PMC4377584.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. PMID: 25731159; PMCID: PMC4447318.
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PubMed Mentions:
323 Fields:
Translation:
HumansAnimalsCells
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Analysis of NF-κB activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606.
Shaked H, Guma M, Karin M. PMID: 25736774.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5. Cell Death Differ. 2015 May; 22(5):852-61.
Kobayashi K, Toguchida J, Karin M, Kato T. PMID: 25526093; PMCID: PMC4392083.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18; 41(6):1052-63.
Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M. PMID: 25526314; PMCID: PMC4272447.
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PubMed Mentions:
168 Fields:
Translation:
HumansAnimalsCells
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Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91.
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. PMID: 25457612; PMCID: PMC4303546.
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PubMed Mentions:
177 Fields:
Translation:
HumansAnimalsCells
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The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5.
Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284; PMCID: PMC4260592.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. FASEB J. 2015 Feb; 29(2):408-17.
Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. PMID: 25366347; PMCID: PMC4314228.
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PubMed Mentions:
82 Fields:
Translation:
AnimalsCells
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Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response. Cancer Res. 2014 Dec 15; 74(24):7274-84.
Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A. PMID: 25336190; PMCID: PMC4349570.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Whipping NF-κB to Submission via GADD45 and MKK7. Cancer Cell. 2014 Oct 13; 26(4):447-9.
Karin M. PMID: 25314072.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 2014 Oct 13; 26(4):549-64.
Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M. PMID: 25314080.
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PubMed Mentions:
305 Fields:
Translation:
HumansAnimalsCells
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Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407.
Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. PMID: 25274633; PMCID: PMC4382461.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977.
Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. PMID: 25266676; PMCID: PMC4298287.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81.
Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. PMID: 25267627; PMCID: PMC4205637.
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PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 03; 33(21):2581-96.
Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. PMID: 25260751; PMCID: PMC4282369.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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PubMed Mentions:
5
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Roles of tumor suppressors in regulating tumor-associated inflammation. Cell Death Differ. 2014 Nov; 21(11):1677-86.
Yang L, Karin M. PMID: 25190145; PMCID: PMC4211367.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimals
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Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5.
Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. PMID: 25189770; PMCID: PMC4183333.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343.
Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. PMID: 25132496; PMCID: PMC4165611.
View in:
PubMed Mentions:
268 Fields:
Translation:
AnimalsCells
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NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nat Commun. 2014 Jul 29; 5:4513.
Fang DF, He K, Wang N, Sang ZH, Qiu X, Xu G, Jian Z, Liang B, Li T, Li HY, Li AL, Zhou T, Gong WL, Yang B, Karin M, Zhang XM, Li WH. PMID: 25072696.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78.
Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318; PMCID: PMC4109552.
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PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
-
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44.
Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. PMID: 24910242; PMCID: PMC4079758.
View in:
PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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The therapeutic value of targeting inflammation in gastrointestinal cancers. Trends Pharmacol Sci. 2014 Jul; 35(7):349-57.
Sun B, Karin M. PMID: 24881011; PMCID: PMC4108072.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14; 25(4):469-83.
Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM. PMID: 24735923; PMCID: PMC3995091.
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PubMed Mentions:
175 Fields:
Translation:
HumansAnimalsCells
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IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 2014 Feb; 26(1):54-74.
Taniguchi K, Karin M. PMID: 24552665.
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PubMed Mentions:
308 Fields:
Translation:
HumansAnimalsCells
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Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med. 2014 Feb; 20(2):126-7.
Karin M, Jobin C, Balkwill F. PMID: 24504404; PMCID: PMC4339017.
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PubMed Mentions:
24 Fields:
Translation:
Animals
-
Tumor infiltrating B-cells are increased in prostate cancer tissue. J Transl Med. 2014 Jan 30; 12:30.
Woo JR, Liss MA, Muldong MT, Palazzi K, Strasner A, Ammirante M, Varki N, Shabaik A, Howell S, Kane CJ, Karin M, Jamieson CA. PMID: 24475900; PMCID: PMC3914187.
View in:
PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):E702-11.
Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. PMID: 24469832; PMCID: PMC3926043.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. PLoS One. 2014; 9(1):e83391.
Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. PMID: 24416163; PMCID: PMC3885413.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7.
Dhar D, Seki E, Karin M. PMID: 24411937; PMCID: PMC3947913.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1090-5.
Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. PMID: 24395807; PMCID: PMC3903249.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91.
Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. PMID: 24333183; PMCID: PMC3960359.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8.
Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. PMID: 24191041; PMCID: PMC3839688.
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PubMed Mentions:
41 Fields:
Translation:
Animals
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Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96.
He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. PMID: 24120137; PMCID: PMC4015514.
View in:
PubMed Mentions:
226 Fields:
Translation:
AnimalsCells
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The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal. 2013 Oct 01; 6(295):ra87.
Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin M, Yagita H, Kang YJ. PMID: 24084649; PMCID: PMC4004444.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 03; 18(6):792-801.
Lee JH, Budanov AV, Karin M. PMID: 24055102; PMCID: PMC3858445.
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PubMed Mentions:
162 Fields:
Translation:
AnimalsCells
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IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Mucosal Immunol. 2014 Mar; 7(2):257-67.
Bonnegarde-Bernard A, Jee J, Fial MJ, Aeffner F, Cormet-Boyaka E, Davis IC, Lin M, Tomé D, Karin M, Sun Y, Boyaka PN. PMID: 23839064; PMCID: PMC4053573.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCellsPHPublic Health
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An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. Genes Dev. 2013 Jul 01; 27(13):1435-40.
Ammirante M, Kuraishy AI, Shalapour S, Strasner A, Ramirez-Sanchez C, Zhang W, Shabaik A, Karin M. PMID: 23796898; PMCID: PMC3713424.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1199-209.e4.
Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. PMID: 23622129; PMCID: PMC3786712.
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PubMed Mentions:
147 Fields:
Translation:
HumansAnimalsCells
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Inflammation and liver tumorigenesis. Front Med. 2013 Jun; 7(2):242-54.
Sun B, Karin M. PMID: 23681888.
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PubMed Mentions:
43 Fields:
Translation:
Humans
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A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 2013 May 13; 23(5):647-59.
Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. PMID: 23602409; PMCID: PMC3981467.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May; 123(5):2231-43.
Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. PMID: 23563314; PMCID: PMC3635720.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog. 2013 Mar; 9(3):e1003234.
Simonin Y, Vegna S, Akkari L, Grégoire D, Antoine E, Piette J, Floc'h N, Lassus P, Yu GY, Rosenberg AR, Karin M, Durantel D, Hibner U. PMID: 23555249; PMCID: PMC3605200.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20; 32(6):816-28.
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. PMID: 23422957; PMCID: PMC3604721.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82.
Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. PMID: 23341606; PMCID: PMC3568328.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Common flora and intestine: A carcinogenic marriage. Cell Logist. 2013 Jan 01; 3(1):e24975.
Wang K, Karin M. PMID: 24516778; PMCID: PMC3906427.
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PubMed Mentions:
3
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p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24.
Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. PMID: 23271722; PMCID: PMC3605785.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013 Apr; 72 Suppl 2:ii100-3.
Wang K, Grivennikov SI, Karin M. PMID: 23253923.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimals
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Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013 Jan 04; 288(1):598-607.
Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW. PMID: 23155052; PMCID: PMC3537058.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8.
Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. PMID: 23034650; PMCID: PMC3601659.
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PubMed Mentions:
668 Fields:
Translation:
HumansAnimalsCells
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Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 2012 Oct 26; 48(2):313-21.
Yu GY, He G, Li CY, Tang M, Grivennikov S, Tsai WT, Wu MS, Hsu CW, Tsai Y, Wang LH, Karin M. PMID: 22959272; PMCID: PMC3483424.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21.
Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. PMID: 22958918; PMCID: PMC3687365.
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PubMed Mentions:
141 Fields:
Translation:
Animals
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Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95.
Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. PMID: 22488549; PMCID: PMC3397277.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12.
Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. PMID: 22893683; PMCID: PMC3435160.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012 Sep 01; 189(5):2089-93.
Gaba A, Grivennikov SI, Do MV, Stumpo DJ, Blackshear PJ, Karin M. PMID: 22865915; PMCID: PMC3424405.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 2012; 8(7):e1002812.
Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. PMID: 22829768; PMCID: PMC3400567.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20.
Seki E, Brenner DA, Karin M. PMID: 22705006; PMCID: PMC3523093.
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PubMed Mentions:
244 Fields:
Translation:
HumansAnimalsCells
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CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2.
Font-Burgada J, Seki E, Karin M. PMID: 22698394; PMCID: PMC4718070.
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PubMed Mentions:
4 Fields:
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IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77.
Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. PMID: 22544702; PMCID: PMC3369682.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade. Biochem J. 2012 Mar 15; 442(3):723-32.
Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA. PMID: 22364283.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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NF-κB and the link between inflammation and cancer. Immunol Rev. 2012 Mar; 246(1):379-400.
DiDonato JA, Mercurio F, Karin M. PMID: 22435567.
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PubMed Mentions:
696 Fields:
Translation:
HumansAnimalsCells
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Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:10-4.
Aghajan M, Li N, Karin M. PMID: 22320909; PMCID: PMC3298015.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):E177-86.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. PMID: 22203995; PMCID: PMC3268290.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84.
Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. PMID: 22196886; PMCID: PMC3268914.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47.
Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. PMID: 22153071; PMCID: PMC3251960.
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PubMed Mentions:
253 Fields:
Translation:
HumansAnimalsCells
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Obesity, inflammation, and liver cancer. J Hepatol. 2012 Mar; 56(3):704-13.
Sun B, Karin M. PMID: 22120206; PMCID: PMC3889660.
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PubMed Mentions:
231 Fields:
Translation:
Humans
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Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507.
Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. PMID: 22389871; PMCID: PMC3290412.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Tumor promotion via injury- and death-induced inflammation. Immunity. 2011 Oct 28; 35(4):467-77.
Kuraishy A, Karin M, Grivennikov SI. PMID: 22035839; PMCID: PMC3587290.
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PubMed Mentions:
126 Fields:
Translation:
HumansAnimals
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Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2.
Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082; PMCID: PMC3428231.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011 Sep 30; 147(1):173-84.
Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. PMID: 21962514; PMCID: PMC3295636.
View in:
PubMed Mentions:
160 Fields:
Translation:
AnimalsCells
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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain. 2011 Sep; 134(Pt 9):2722-35.
Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. PMID: 21908876.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14.
Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. PMID: 21815634; PMCID: PMC3174326.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900.
Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. PMID: 21825016; PMCID: PMC3171091.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13710-5.
Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, Karin M, Costanzo A. PMID: 21807998; PMCID: PMC3158164.
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PubMed Mentions:
81 Fields:
Translation:
HumansCells
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Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol. 2011 Jul 19; 12(8):715-23.
Ben-Neriah Y, Karin M. PMID: 21772280.
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PubMed Mentions:
671 Fields:
Translation:
HumansAnimals
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Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 2011 Jul 22; 35(1):34-44.
Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. PMID: 21683629; PMCID: PMC3889666.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell. 2011 Jun 14; 19(6):740-53.
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 21665148.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011 Jun 10; 11(7):457-68.
Häcker H, Tseng PH, Karin M. PMID: 21660053.
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PubMed Mentions:
214 Fields:
Translation:
HumansAnimalsCells
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JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12.
Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. PMID: 21305529; PMCID: PMC3106119.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol. 2011 May; 41(5):1266-77.
Kang J, Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ. PMID: 21469085.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell. 2011 Apr 12; 19(4):429-31.
Li N, Grivennikov SI, Karin M. PMID: 21481782; PMCID: PMC3111086.
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PubMed Mentions:
136 Fields:
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Crystal structure of inhibitor of κB kinase β. Nature. 2011 Apr 21; 472(7343):325-30.
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. PMID: 21423167; PMCID: PMC3081413.
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PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Transcriptional regulation of the Th17 immune response by IKK(alpha). J Exp Med. 2011 Apr 11; 208(4):787-96.
Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. PMID: 21402739; PMCID: PMC3135338.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011 Mar; 70 Suppl 1:i104-8.
Grivennikov SI, Karin M. PMID: 21339211.
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PubMed Mentions:
257 Fields:
Translation:
HumansAnimals
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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53.
Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. PMID: 21326202; PMCID: PMC3166217.
View in:
PubMed Mentions:
323 Fields:
Translation:
HumansAnimalsCells
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IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun. 2011; 2:318.
Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. PMID: 21587235; PMCID: PMC3113230.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci. 2011 Jan; 1217:191-206.
Kim S, Karin M. PMID: 21276007; PMCID: PMC4383094.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimals
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NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res. 2011 Jan; 21(1):159-68.
He G, Karin M. PMID: 21187858; PMCID: PMC3193410.
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PubMed Mentions:
551 Fields:
Translation:
AnimalsCells
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Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13.
Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249; PMCID: PMC3017162.
View in:
PubMed Mentions:
173 Fields:
Translation:
HumansAnimalsCells
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IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ. Nat Immunol. 2011 Feb; 12(2):144-50.
Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Sinzig U, Aung T, Nizet V, Weissman IL, Karin M. PMID: 21170027; PMCID: PMC3677078.
View in:
PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
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JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7.
Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. PMID: 21135226; PMCID: PMC3009768.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. Nano Lett. 2010 Dec 08; 10(12):5088-92.
Kong SD, Zhang W, Lee JH, Brammer K, Lal R, Karin M, Jin S. PMID: 21038917.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimals
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B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18956-60.
Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ. PMID: 20956327; PMCID: PMC2973856.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Stressin' Sestrins take an aging fight. EMBO Mol Med. 2010 Oct; 2(10):388-400.
Budanov AV, Lee JH, Karin M. PMID: 20878915; PMCID: PMC3166214.
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PubMed Mentions:
116 Fields:
Translation:
Humans
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Peering into the aftermath: JAKi rips STAT3 in cancer. Nat Med. 2010 Oct; 16(10):1085-7.
Greten FR, Karin M. PMID: 20930749.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Sphingolipids: the oil on the TRAFire that promotes inflammation. Sci Signal. 2010 Sep 28; 3(141):pe34.
Napolitano G, Karin M. PMID: 20876871.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010 Oct 01; 70(19):7465-75.
Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. PMID: 20841473; PMCID: PMC2948598.
View in:
PubMed Mentions:
338 Fields:
Translation:
AnimalsCells
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Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 2010 Sep 24; 33(3):400-11.
Pérez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, Vallabhapurapu S, Bravo J, Warnatz K, Chaix Y, Cascarrigny F, Lebon P, Rozenberg F, Karin M, Tardieu M, Al-Muhsen S, Jouanguy E, Zhang SY, Abel L, Casanova JL. PMID: 20832341; PMCID: PMC2946444.
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PubMed Mentions:
175 Fields:
Translation:
HumansCells
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Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell. 2010 Aug 27; 39(4):570-82.
Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H. PMID: 20797629.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest. 2010 Jul; 120(7):2563-74.
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. PMID: 20530876; PMCID: PMC2898608.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Inflammation and colon cancer. Gastroenterology. 2010 Jun; 138(6):2101-2114.e5.
Terzic J, Grivennikov S, Karin E, Karin M. PMID: 20420949.
View in:
PubMed Mentions:
935 Fields:
Translation:
HumansAnimalsCells
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Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74.
Lee JH, Bodmer R, Bier E, Karin M. PMID: 20606249; PMCID: PMC2919257.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimals
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Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12.
Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. PMID: 20494824; PMCID: PMC2908188.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51.
Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. PMID: 20386472; PMCID: PMC2941912.
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PubMed Mentions:
134 Fields:
Translation:
HumansAnimals
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JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 2010 Aug; 24(8):2596-611.
Solinas G, Karin M. PMID: 20371626.
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PubMed Mentions:
138 Fields:
Translation:
Humans
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Immunity, inflammation, and cancer. Cell. 2010 Mar 19; 140(6):883-99.
Grivennikov SI, Greten FR, Karin M. PMID: 20303878; PMCID: PMC2866629.
View in:
PubMed Mentions:
4798 Fields:
Translation:
HumansAnimals
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Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010 Mar 16; 17(3):286-97.
He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. PMID: 20227042; PMCID: PMC2841312.
View in:
PubMed Mentions:
213 Fields:
Translation:
HumansAnimalsCells
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B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 2010 Mar 11; 464(7286):302-5.
Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. PMID: 20220849; PMCID: PMC2866639.
View in:
PubMed Mentions:
320 Fields:
Translation:
HumansAnimalsCells
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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8.
Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043; PMCID: PMC2866632.
View in:
PubMed Mentions:
288 Fields:
Translation:
AnimalsCells
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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010 Jan 22; 140(2):197-208.
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. PMID: 20141834; PMCID: PMC2836922.
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PubMed Mentions:
818 Fields:
Translation:
Animals
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NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem. 2010 Mar 26; 285(13):9706-9715.
Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS. PMID: 20097762; PMCID: PMC2843220.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97.
Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. PMID: 20129250; PMCID: PMC2818776.
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PubMed Mentions:
233 Fields:
Translation:
AnimalsPHPublic Health
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Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev. 2010 Feb; 20(1):65-71.
Grivennikov SI, Karin M. PMID: 20036794; PMCID: PMC2821983.
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PubMed Mentions:
210 Fields:
Translation:
HumansCells
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Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010 Feb; 21(1):11-9.
Grivennikov SI, Karin M. PMID: 20018552; PMCID: PMC2834864.
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PubMed Mentions:
544 Fields:
Translation:
HumansAnimalsCells
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Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J Immunol. 2009 Dec 15; 183(12):7877-89.
Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. PMID: 20007573; PMCID: PMC4095798.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 2010 Mar; 138(3):1022-34.e1-10.
Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. PMID: 19962981; PMCID: PMC2831162.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology. 2009 Dec; 50(6):1851-60.
Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. PMID: 19821485.
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PubMed Mentions:
30 Fields:
Translation:
Animals
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Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50.
Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. PMID: 19950258; PMCID: PMC2847793.
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PubMed Mentions:
142 Fields:
Translation:
AnimalsCells
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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010 Jan; 11(1):70-5.
Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. PMID: 19898473; PMCID: PMC2872790.
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PubMed Mentions:
205 Fields:
Translation:
AnimalsCells
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NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov; 1(5):a000141.
Karin M. PMID: 20066113; PMCID: PMC2773649.
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PubMed Mentions:
407 Fields:
Translation:
HumansAnimalsCells
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A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009 Oct 06; 16(4):295-308.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. PMID: 19800575; PMCID: PMC4422166.
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PubMed Mentions:
175 Fields:
Translation:
HumansAnimalsCells
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Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009 Nov 12; 114(20):4469-76.
Enzler T, Kater AP, Zhang W, Widhopf GF, Chuang HY, Lee J, Avery E, Croce CM, Karin M, Kipps TJ. PMID: 19755673.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. J Immunol. 2009 Sep 15; 183(6):3831-8.
Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. PMID: 19710465.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 2009 Aug 19; 4(8):e6695.
Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM. PMID: 19690611; PMCID: PMC2723911.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
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NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8.
Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. PMID: 19541630; PMCID: PMC2722361.
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PubMed Mentions:
105 Fields:
Translation:
AnimalsCells
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Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5.
Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. PMID: 19433784; PMCID: PMC2688966.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev. 2009 Mar; 228(1):225-40.
Karin M, Gallagher E. PMID: 19290931.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565.
Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. PMID: 19203587.
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PubMed Mentions: Fields:
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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13.
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. PMID: 19185845; PMCID: PMC2667107.
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PubMed Mentions:
1049 Fields:
Translation:
HumansAnimalsCells
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Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):349-54.
Koch KS, Maeda S, He G, Karin M, Leffert HL. PMID: 19171122; PMCID: PMC2663043.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 2009 Jan 01; 457(7225):102-6.
Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M. PMID: 19122641; PMCID: PMC2746432.
View in:
PubMed Mentions:
541 Fields:
Translation:
AnimalsCells
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Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009 Jan; 8(1):33-40.
Baud V, Karin M. PMID: 19116625; PMCID: PMC2729321.
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PubMed Mentions:
485 Fields:
Translation:
HumansAnimalsCells
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Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009; 27:693-733.
Vallabhapurapu S, Karin M. PMID: 19302050.
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PubMed Mentions:
1215 Fields:
Translation:
HumansAnimalsCells
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Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20197-202.
Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA. PMID: 19091944; PMCID: PMC2629300.
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PubMed Mentions:
32 Fields:
Translation:
Cells
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Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71.
Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. PMID: 19001420; PMCID: PMC2613605.
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PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008 Dec; 9(12):1364-70.
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. PMID: 18997792; PMCID: PMC2671996.
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PubMed Mentions:
335 Fields:
Translation:
HumansAnimalsCells
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The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17091-6.
Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. PMID: 18957551; PMCID: PMC2579383.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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NF-kappaB signaling, liver disease and hepatoprotective agents. Oncogene. 2008 Oct 20; 27(48):6228-44.
Sun B, Karin M. PMID: 18931690.
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PubMed Mentions:
112 Fields:
Translation:
HumansCells
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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13.
Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. PMID: 18922779; PMCID: PMC2567907.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008 Oct 03; 135(1):61-73.
Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. PMID: 18854155; PMCID: PMC2586330.
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PubMed Mentions:
614 Fields:
Translation:
HumansAnimalsCells
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Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Oct; 237(10):2926-35.
Hou Y, Li F, Karin M, Ostrowski MC. PMID: 18816823; PMCID: PMC2998709.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain. 2008 Nov; 131(Pt 11):3019-33.
Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE, Lee S, Kim CH, Kim DW, Jo EK, Lee KE, Karin M, Lee SJ. PMID: 18819987; PMCID: PMC2577806.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J. 2008 Oct 22; 27(20):2639-47.
Descargues P, Sil AK, Karin M. PMID: 18818691; PMCID: PMC2556095.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15058-63.
Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. PMID: 18815378; PMCID: PMC2567492.
View in:
PubMed Mentions:
87 Fields:
Translation:
Animals
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Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 2008 Aug 12; 14(2):156-65.
Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. PMID: 18691550; PMCID: PMC2707922.
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PubMed Mentions:
242 Fields:
Translation:
AnimalsCells
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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 08; 134(3):451-60.
Budanov AV, Karin M. PMID: 18692468; PMCID: PMC2758522.
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PubMed Mentions:
686 Fields:
Translation:
HumansAnimalsCells
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Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One. 2008 Jul 23; 3(7):e2769.
Meinzer U, Esmiol-Welterlin S, Barreau F, Berrebi D, Dussaillant M, Bonacorsi S, Chareyre F, Niwa-Kawakita M, Alberti C, Sterkers G, Villard C, Lesuffleur T, Peuchmaur M, Karin M, Eckmann L, Giovannini M, Ollendorff V, Wolf-Watz H, Hugot JP. PMID: 18648508; PMCID: PMC2447872.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9.
Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. PMID: 18633439.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008 Aug 01; 321(5889):663-8.
Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. PMID: 18635759; PMCID: PMC2669719.
View in:
PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 2008 Oct; 135(4):1311-21.
Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M. PMID: 18700144.
View in:
PubMed Mentions:
129 Fields:
Translation:
AnimalsCells
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The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell. 2008 Jul 08; 14(1):10-21.
Bernassola F, Karin M, Ciechanover A, Melino G. PMID: 18598940.
View in:
PubMed Mentions:
293 Fields:
Translation:
HumansAnimalsCells
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c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 2008 Jul 01; 68(13):5031-9.
Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. PMID: 18593901.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Prion propagation in mice lacking central nervous system NF-kappaB signalling. J Gen Virol. 2008 Jun; 89(Pt 6):1545-1550.
Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A. PMID: 18474572.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8.
Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. PMID: 18511561; PMCID: PMC2409384.
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PubMed Mentions:
174 Fields:
Translation:
HumansAnimalsCells
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An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76.
Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. PMID: 18490491; PMCID: PMC2413025.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 2008 Feb; 18(1):19-26.
Naugler WE, Karin M. PMID: 18440219; PMCID: PMC2587362.
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PubMed Mentions:
302 Fields:
Translation:
HumansCells
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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11.
Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192; PMCID: PMC2669289.
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PubMed Mentions:
689 Fields:
Translation:
AnimalsCells
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The IkappaB kinase - a bridge between inflammation and cancer. Cell Res. 2008 Mar; 18(3):334-42.
Karin M. PMID: 18301380.
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PubMed Mentions:
121 Fields:
Translation:
HumansAnimals
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Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell. 2008 Feb 15; 29(3):279-90.
Herrlich P, Karin M, Weiss C. PMID: 18280234; PMCID: PMC2714880.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2487-92.
Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M. PMID: 18268325; PMCID: PMC2268163.
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PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
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The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008 Mar; 14(3):109-19.
Naugler WE, Karin M. PMID: 18261959.
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PubMed Mentions:
302 Fields:
Translation:
HumansAnimalsCells
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Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell. 2008 Jan; 13(1):7-9.
Grivennikov S, Karin M. PMID: 18167335.
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PubMed Mentions:
172 Fields:
Translation:
HumansCells
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From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev. 2007 Dec; 220:8-21.
Temkin V, Karin M. PMID: 17979836.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Rsk Tolls the bell for endocytosis in DCs. Nat Immunol. 2007 Nov; 8(11):1197-9.
Karin M. PMID: 17952046.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97.
Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. PMID: 17983584.
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PubMed Mentions:
262 Fields:
Translation:
AnimalsCells
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Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90.
Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. PMID: 17924664.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15852-7.
Cao Y, Luo JL, Karin M. PMID: 17890319; PMCID: PMC2000410.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007 Sep 07; 130(5):918-31.
Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. PMID: 17803913; PMCID: PMC2134986.
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PubMed Mentions:
319 Fields:
Translation:
HumansAnimalsCells
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Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin Cancer Res. 2007 Sep 01; 13(17):4956-9.
Van Waes C, Yu M, Nottingham L, Karin M. PMID: 17785544.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007 Jul 06; 317(5834):121-4.
Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. PMID: 17615358.
View in:
PubMed Mentions:
871 Fields:
Translation:
AnimalsCells
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IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. Crit Care Med. 2007 May; 35(5):1332-40.
Chen LW, Chen PH, Chang WJ, Wang JS, Karin M, Hsu CM. PMID: 17414734.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007 May; 117(5):1175-83.
Lin WW, Karin M. PMID: 17476347; PMCID: PMC1857251.
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PubMed Mentions:
744 Fields:
Translation:
HumansAnimals
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Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6359-64.
Mills DM, Bonizzi G, Karin M, Rickert RC. PMID: 17404218; PMCID: PMC1851084.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901.
Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. PMID: 17380205; PMCID: PMC1821069.
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PubMed Mentions:
221 Fields:
Translation:
HumansAnimalsCells
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Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4.
Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. PMID: 17377533.
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PubMed Mentions:
209 Fields:
Translation:
HumansAnimalsCells
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Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007 Mar 29; 446(7135):552-6.
Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D. PMID: 17322906.
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PubMed Mentions:
227 Fields:
Translation:
AnimalsCells
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p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60.
Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. PMID: 17360634; PMCID: PMC1805532.
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PubMed Mentions:
123 Fields:
Translation:
AnimalsCells
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NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1913-8.
Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS. PMID: 17267600; PMCID: PMC1794308.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Adv Exp Med Biol. 2007; 602:125-34.
Ruocco MG, Karin M. PMID: 17966397.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos. 2007 Mar; 35(3):402-9.
Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ. PMID: 17151194.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol. 2007 Jan; 8(1):57-63.
Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. PMID: 17143273.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Role for IKK2 in muscle: waste not, want not. J Clin Invest. 2006 Nov; 116(11):2866-8.
Karin M. PMID: 17080193; PMCID: PMC1626137.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol. 2006 Nov 01; 177(9):6344-52.
Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. PMID: 17056565.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16454-9.
Solinas G, Naugler W, Galimi F, Lee MS, Karin M. PMID: 17050683; PMCID: PMC1637603.
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PubMed Mentions:
113 Fields:
Translation:
HumansAnimalsCells
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Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006 Oct 17; 2006(357):re13.
Häcker H, Karin M. PMID: 17047224.
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PubMed Mentions:
599 Fields:
Translation:
HumansAnimalsCells
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BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10.
Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ. PMID: 16973958; PMCID: PMC1890820.
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PubMed Mentions:
82 Fields:
Translation:
HumansCells
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Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. J Biol Chem. 2006 Dec 01; 281(48):37142-9.
Chen F, Lu Y, Castranova V, Li Z, Karin M. PMID: 16966325.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 2006 Sep; 25(3):403-15.
Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. PMID: 16973390.
View in:
PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells. Eur J Immunol. 2006 Aug; 36(8):2076-84.
Labuda T, Christensen JP, Rasmussen S, Bonnesen B, Karin M, Thomsen AR, Odum N. PMID: 16761309.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. 2007 Feb 08; 26(6):851-8.
Lin R, Maeda S, Liu C, Karin M, Edgington TS. PMID: 16878148.
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PubMed Mentions:
262 Fields:
Translation:
HumansAnimalsCells
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Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20.
Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. PMID: 16818780.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Intracellular pattern recognition receptors in the host response. Nature. 2006 Jul 06; 442(7098):39-44.
Meylan E, Tschopp J, Karin M. PMID: 16823444.
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PubMed Mentions:
441 Fields:
Translation:
HumansAnimals
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Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10741-6.
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. PMID: 16818881; PMCID: PMC1487172.
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PubMed Mentions:
144 Fields:
Translation:
HumansAnimalsCells
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Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10544-51.
Sakurai T, Maeda S, Chang L, Karin M. PMID: 16807293; PMCID: PMC1502270.
View in:
PubMed Mentions:
199 Fields:
Translation:
AnimalsCells
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NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun; 45(6):355-61.
Karin M. PMID: 16673382.
View in:
PubMed Mentions:
120 Fields:
Translation:
HumansCells
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Nuclear factor-kappaB in cancer development and progression. Nature. 2006 May 25; 441(7092):431-6.
Karin M. PMID: 16724054.
View in:
PubMed Mentions:
1523 Fields:
Translation:
HumansAnimals
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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem. 2006 Jul 28; 281(30):21458-21468.
Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. PMID: 16717090.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest. 2006 Apr; 116(4):1117-26.
Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC. PMID: 16557301; PMCID: PMC1409741.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35.
Karin M, Lawrence T, Nizet V. PMID: 16497591.
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PubMed Mentions:
370 Fields:
Translation:
HumansAnimalsCells
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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006 Feb 10; 124(3):601-13.
Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. PMID: 16469705.
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PubMed Mentions:
322 Fields:
Translation:
AnimalsCells
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Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9.
Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. PMID: 16455799; PMCID: PMC1413899.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2292-7.
Mahieu T, Park JM, Revets H, Pasche B, Lengeling A, Staelens J, Wullaert A, Vanlaere I, Hochepied T, van Roy F, Karin M, Libert C. PMID: 16455798; PMCID: PMC1413734.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1717-22.
Gallagher E, Gao M, Liu YC, Karin M. PMID: 16446428; PMCID: PMC1413664.
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PubMed Mentions:
152 Fields:
Translation:
HumansCells
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Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). Harvey Lect. 2006-2007; 102:133-51.
Karin M. PMID: 20166567.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005 Dec 22; 20(6):891-903.
Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R. PMID: 16364914.
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PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
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Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 2005 Dec; 5(12):941-52.
Liu YC, Penninger J, Karin M. PMID: 16322747; PMCID: PMC7096784.
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PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8.
Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. PMID: 16317067; PMCID: PMC1308936.
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PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7.
Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. PMID: 16306937.
View in:
PubMed Mentions:
387 Fields:
Translation:
AnimalsCells
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The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol. 2005 Nov; 25(6):541-50.
Luo JL, Kamata H, Karin M. PMID: 16380818.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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IKK{beta} as a target for treatment of inflammation induced bone loss. Ann Rheum Dis. 2005 Nov; 64 Suppl 4:iv81-5.
Ruocco MG, Karin M. PMID: 16239395; PMCID: PMC1766902.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005 Oct; 5(10):749-59.
Karin M, Greten FR. PMID: 16175180.
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PubMed Mentions:
1257 Fields:
Translation:
HumansAnimalsCells
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IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest. 2005 Oct; 115(10):2625-32.
Luo JL, Kamata H, Karin M. PMID: 16200195; PMCID: PMC1236696.
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PubMed Mentions:
329 Fields:
Translation:
HumansAnimalsCells
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Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell. 2005 Sep 02; 19(5):581-93.
Gao M, Karin M. PMID: 16137616.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29.
Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. PMID: 16169504.
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PubMed Mentions:
147 Fields:
Translation:
AnimalsCells
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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005 Jul 01; 121(7):977-90.
Maeda S, Kamata H, Luo JL, Leffert H, Karin M. PMID: 15989949.
View in:
PubMed Mentions:
539 Fields:
Translation:
AnimalsCells
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NOD2 and Crohn's disease: loss or gain of function? Immunity. 2005 Jun; 22(6):661-7.
Eckmann L, Karin M. PMID: 15963781.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimals
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Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. EMBO Rep. 2005 Jun; 6(6):531-7.
Zhang P, Chan J, Dragoi AM, Gong X, Ivanov S, Li ZW, Chuang TH, Chuang T, Tuthill C, Wan Y, Karin M, Chu WM. PMID: 15905851; PMCID: PMC1369095.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005 May 16; 201(10):1677-87.
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M. PMID: 15897281; PMCID: PMC2212920.
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PubMed Mentions:
107 Fields:
Translation:
AnimalsCells
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IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43.
Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. PMID: 15858576.
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PubMed Mentions:
283 Fields:
Translation:
AnimalsCells
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From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life. 2005 Apr-May; 57(4-5):283-95.
Karin M, Gallagher E. PMID: 16036612.
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PubMed Mentions:
169 Fields:
Translation:
HumansAnimalsCells
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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11; 120(5):649-61.
Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. PMID: 15766528.
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PubMed Mentions:
744 Fields:
Translation:
HumansAnimalsCells
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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 04; 307(5710):734-8.
Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. PMID: 15692052.
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PubMed Mentions:
266 Fields:
Translation:
AnimalsCells
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IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8.
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. PMID: 15685170.
View in:
PubMed Mentions:
770 Fields:
Translation:
AnimalsCells
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Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc. 2005; 2(4):386-90; discussion 394-5.
Karin M. PMID: 16267367; PMCID: PMC2713329.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimals
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Inflammation and cancer: the long reach of Ras. Nat Med. 2005 Jan; 11(1):20-1.
Karin M. PMID: 15635437.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimals
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Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med. 2004 Dec 20; 200(12):1647-55.
Park JM, Ng VH, Maeda S, Rest RF, Karin M. PMID: 15611291; PMCID: PMC2211988.
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PubMed Mentions:
120 Fields:
Translation:
AnimalsCells
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Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17813-8.
Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. PMID: 15601766; PMCID: PMC539759.
View in:
PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
-
I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. J Immunol. 2004 Nov 15; 173(10):6161-8.
Drayton DL, Bonizzi G, Ying X, Liao S, Karin M, Ruddle NH. PMID: 15528353.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
-
Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs. Ann Rheum Dis. 2004 Nov; 63 Suppl 2:ii62-ii64.
Karin M. PMID: 15479874; PMCID: PMC1766783.
View in:
PubMed Mentions:
16 Fields:
Translation:
Humans
-
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10.
Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. PMID: 15470505; PMCID: PMC524385.
View in:
PubMed Mentions:
148 Fields:
Translation:
AnimalsCells
-
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell. 2004 Sep 10; 15(5):713-25.
Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. PMID: 15350216.
View in:
PubMed Mentions:
174 Fields:
Translation:
AnimalsCells
-
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004 Oct 08; 306(5694):271-5.
Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. PMID: 15358865.
View in:
PubMed Mentions:
187 Fields:
Translation:
AnimalsCells
-
Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 2004 Sep; 6(3):297-305.
Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. PMID: 15380520.
View in:
PubMed Mentions:
230 Fields:
Translation:
AnimalsCells
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004 Aug 06; 118(3):285-96.
Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. PMID: 15294155.
View in:
PubMed Mentions:
1072 Fields:
Translation:
AnimalsCells
-
CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation. J Neuroimmunol. 2004 Aug; 153(1-2):50-63.
Lee S, Hong J, Choi SY, Oh SB, Park K, Kim JS, Karin M, Lee SJ. PMID: 15265663.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol. 2004 Jul; 24(13):5914-22.
Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG. PMID: 15199146; PMCID: PMC480890.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Genetic dissection of antigen receptor induced-NF-kappaB activation. Mol Immunol. 2004 Jul; 41(6-7):701-14.
Li ZW, Rickert RC, Karin M. PMID: 15220005.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell. 2004 Jun 04; 14(5):571-83.
Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY. PMID: 15175153.
View in:
PubMed Mentions:
202 Fields:
Translation:
HumansCells
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The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004 Jun; 25(6):280-8.
Bonizzi G, Karin M. PMID: 15145317.
View in:
PubMed Mentions:
952 Fields:
Translation:
AnimalsCells
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The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004 Apr 08; 206(2):193-9.
Greten FR, Karin M. PMID: 15013524.
View in:
PubMed Mentions:
138 Fields:
Translation:
HumansAnimalsCells
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IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4.
Sil AK, Maeda S, Sano Y, Roop DR, Karin M. PMID: 15071597.
View in:
PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 2004 Apr 01; 23(14):2540-7.
Amir RE, Haecker H, Karin M, Ciechanover A. PMID: 14676825.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
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The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76.
Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. PMID: 15037607.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5.
Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. PMID: 15029200.
View in:
PubMed Mentions:
151 Fields:
Translation:
AnimalsCells
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Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev. 2004 Mar 01; 18(5):584-94.
Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA. PMID: 15037551; PMCID: PMC374239.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2452-7.
Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. PMID: 14983030; PMCID: PMC356971.
View in:
PubMed Mentions:
93 Fields:
Translation:
Animals
-
A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb; 6(2):219-27.
Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT. PMID: 14960276.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 2004 Feb; 14(2):94-101.
Xia Y, Karin M. PMID: 15102441.
View in:
PubMed Mentions:
102 Fields:
Translation:
HumansAnimalsCells
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The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov. 2004 Jan; 3(1):17-26.
Karin M, Yamamoto Y, Wang QM. PMID: 14708018.
View in:
PubMed Mentions:
442 Fields:
Translation:
HumansAnimalsCells
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Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Res. 2003 Nov 15; 63(22):7689-93.
Chen F, Castranova V, Li Z, Karin M, Shi X. PMID: 14633691.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov; 23(21):7780-93.
Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. PMID: 14560022; PMCID: PMC207563.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 2003 Nov; 19(5):725-37.
Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. PMID: 14614859.
View in:
PubMed Mentions:
128 Fields:
Translation:
AnimalsCells
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CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell. 2003 Oct; 12(4):829-39.
Kato T, Delhase M, Hoffmann A, Karin M. PMID: 14580335.
View in:
PubMed Mentions:
127 Fields:
Translation:
HumansCells
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A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 2003 Sep 01; 22(17):4443-54.
Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y. PMID: 12941696; PMCID: PMC202382.
View in:
PubMed Mentions:
82 Fields:
Translation:
AnimalsCells
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Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J. 2003 Jul 01; 22(13):3356-66.
Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. PMID: 12839997; PMCID: PMC165656.
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PubMed Mentions:
114 Fields:
Translation:
HumansCells
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Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions. J Histochem Cytochem. 2003 May; 51(5):555-65.
Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L. PMID: 12704203.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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IKK beta is required for peripheral B cell survival and proliferation. J Immunol. 2003 May 01; 170(9):4630-7.
Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. PMID: 12707341.
View in:
PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003 May; 9(5):575-81.
Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. PMID: 12692538.
View in:
PubMed Mentions:
188 Fields:
Translation:
Animals
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NF-kappaB in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):215-23.
Cao Y, Karin M. PMID: 14635796.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33.
Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. PMID: 12689591.
View in:
PubMed Mentions:
162 Fields:
Translation:
AnimalsCells
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NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14.
Lin A, Karin M. PMID: 12654254.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansAnimalsCells
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The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33.
Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. PMID: 12637498.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol. 2003 Feb; 23(3):1061-74.
Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. PMID: 12529410; PMCID: PMC140693.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Oncogene at last--c-Jun promotes liver cancer in mice. Cancer Cell. 2003 Feb; 3(2):102-4.
Maeda S, Karin M. PMID: 12620404.
View in:
PubMed Mentions:
22 Fields:
Translation:
Animals
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The control of mRNA stability in response to extracellular stimuli. Mol Cells. 2002 Dec 31; 14(3):323-31.
Shim J, Karin M. PMID: 12521293.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell. 2002 Dec; 2(6):431-3.
Häcker H, Karin M. PMID: 12498710.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell. 2002 Dec; 10(6):1331-44.
Shim J, Lim H, R Yates J, Karin M. PMID: 12504009.
View in:
PubMed Mentions:
92 Fields:
Translation:
HumansCells
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A central role for JNK in obesity and insulin resistance. Nature. 2002 Nov 21; 420(6913):333-6.
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 12447443.
View in:
PubMed Mentions:
1253 Fields:
Translation:
AnimalsCells
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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002 Oct; 17(4):525-35.
Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. PMID: 12387745.
View in:
PubMed Mentions:
368 Fields:
Translation:
HumansAnimalsCells
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Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem. 2002 Oct 04; 277(40):37896-903.
Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y. PMID: 12138127.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002 May; 4(5):E131-6.
Shaulian E, Karin M. PMID: 11988758.
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PubMed Mentions:
1023 Fields:
Translation:
AnimalsCells
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Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1631-5.
Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M. PMID: 11980884.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002 Apr; 2(4):301-10.
Karin M, Cao Y, Greten FR, Li ZW. PMID: 12001991.
View in:
PubMed Mentions:
917 Fields:
Translation:
HumansAnimalsCells
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Missing pieces in the NF-kappaB puzzle. Cell. 2002 Apr; 109 Suppl:S81-96.
Ghosh S, Karin M. PMID: 11983155.
View in:
PubMed Mentions:
1225 Fields:
Translation:
HumansAnimalsCells
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NF-kappaB at the crossroads of life and death. Nat Immunol. 2002 Mar; 3(3):221-7.
Karin M, Lin A. PMID: 11875461.
View in:
PubMed Mentions:
918 Fields:
Translation:
HumansAnimals
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Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum. 2002 Mar; 46(3):818-23.
Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. PMID: 11920420.
View in:
PubMed Mentions:
43 Fields:
Translation:
Animals
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The IKK/NF-kappaB pathway. Crit Care Med. 2002 Jan; 30(1 Supp):S18-S26.
Senftleben U, Karin M. PMID: 11891403.
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PubMed Mentions:
35 Fields:
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The IKK/NF-kappa B pathway. Crit Care Med. 2002 Jan; 30(1 Suppl):S18-26.
Senftleben U, Karin M. PMID: 11782557.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001 Dec 14; 107(6):763-75.
Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. PMID: 11747812.
View in:
PubMed Mentions:
186 Fields:
Translation:
HumansAnimalsCells
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AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell. 2001 Nov 16; 107(4):451-64.
Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M. PMID: 11719186.
View in:
PubMed Mentions:
384 Fields:
Translation:
HumansAnimalsCells
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Inhibition of JNK activation through NF-kappaB target genes. Nature. 2001 Nov 15; 414(6861):313-7.
Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. PMID: 11713531.
View in:
PubMed Mentions:
246 Fields:
Translation:
HumansAnimalsCells
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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001 Aug 24; 293(5534):1495-9.
Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. PMID: 11520989.
View in:
PubMed Mentions:
540 Fields:
Translation:
AnimalsCells
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AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. IUBMB Life. 2001 Jul; 52(1-2):17-24.
Karin M, Shaulian E. PMID: 11795587.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul; 108(1):73-81.
Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. PMID: 11435459; PMCID: PMC209341.
View in:
PubMed Mentions:
241 Fields:
Translation:
AnimalsCells
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c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene. 2001 Jun 07; 20(26):3443-8.
Jiménez B, Volpert OV, Reiher F, Chang L, Muñoz A, Karin M, Bouck N. PMID: 11423995.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol Cell Biol. 2001 Jun; 21(12):3986-94.
Devin A, Lin Y, Yamaoka S, Li Z, Karin M. PMID: 11359906; PMCID: PMC87061.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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AP-1--glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol. 2001 Jun; 169(3):447-51.
Karin M, Chang L. PMID: 11375114.
View in:
PubMed Mentions:
38 Fields:
Translation:
Humans
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AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation. Mol Cell Biol. 2001 May; 21(9):3012-24.
Piu F, Aronheim A, Katz S, Karin M. PMID: 11287607; PMCID: PMC86930.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol. 2001 May 01; 209(2):149-57.
Ojo-Amaize EA, Kapahi P, Kakkanaiah VN, Takahashi T, Shalom-Barak T, Cottam HB, Adesomoju AA, Nchekwube EJ, Oyemade OA, Karin M, Okogun JI. PMID: 11446747.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 2001 Apr 05; 410(6829):710-4.
Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. PMID: 11287960.
View in:
PubMed Mentions:
130 Fields:
Translation:
HumansAnimalsCells
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IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity. 2001 Mar; 14(3):217-30.
Senftleben U, Li ZW, Baud V, Karin M. PMID: 11290332.
View in:
PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Mammalian MAP kinase signalling cascades. Nature. 2001 Mar 01; 410(6824):37-40.
Chang L, Karin M. PMID: 11242034.
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PubMed Mentions:
1631 Fields:
Translation:
AnimalsCells
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c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med. 2001 Feb 05; 193(3):317-28.
Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. PMID: 11157052; PMCID: PMC2195924.
View in:
PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol Cell. 2001 Feb; 7(2):421-32.
Cavalli V, Vilbois F, Corti M, Marcote MJ, Tamura K, Karin M, Arkinstall S, Gruenberg J. PMID: 11239470.
View in:
PubMed Mentions:
120 Fields:
Translation:
HumansAnimalsCells
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Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. Mol Endocrinol. 2001 Jan; 15(1):32-45.
Feng W, Webb P, Nguyen P, Liu X, Li J, Karin M, Kushner PJ. PMID: 11145737.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors. 2001; 15(2-4):87-9.
Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. PMID: 12016332.
View in:
PubMed Mentions:
48 Fields:
Translation:
Humans
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ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. J Biol Chem. 2001 Mar 23; 276(12):8898-903.
Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G. PMID: 11114307.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell. 2000 Dec 08; 103(6):897-907.
Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. PMID: 11136975.
View in:
PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2000 Dec 08; 103(6):909-18.
Chu W, Gong X, Li Z, Takabayashi K, Ouyang H, Chen Y, Lois A, Chen DJ, Li GC, Karin M, Raz E. PMID: 11136976.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17; 275(46):36062-6.
Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. PMID: 10967126.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansCells
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IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3665-9.
Yoshida K, Hu Y, Karin M. PMID: 11053261.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
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Kinase regulation in inflammatory response. Nature. 2000 Jul 27; 406(6794):367-8.
Delhase M, Li N, Karin M. PMID: 10935625.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21; 102(2):221-31.
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. PMID: 10943842.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2. J Biol Chem. 2000 Jul 14; 275(28):21653-60.
López-Fernández J, Palacios D, Castillo AI, Tolon RM, Aranda A, Karin M. PMID: 10801832.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell. 2000 Jul 07; 102(1):67-76.
Spence J, Gali RR, Dittmar G, Sherman F, Karin M, Finley D. PMID: 10929714.
View in:
PubMed Mentions:
129 Fields:
Translation:
HumansAnimalsCells
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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun; 5(6):969-79.
Makris C, Godfrey VL, Krähn-Senftleben G, Takahashi T, Roberts JL, Schwarz T, Feng L, Johnson RS, Karin M. PMID: 10911991.
View in:
PubMed Mentions:
117 Fields:
Translation:
HumansAnimalsCells
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p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol. 2000 Jun; 20(11):3951-64.
Wu Z, Woodring PJ, Bhakta KS, Tamura K, Wen F, Feramisco JR, Karin M, Wang JY, Puri PL. PMID: 10805738; PMCID: PMC85749.
View in:
PubMed Mentions:
187 Fields:
Translation:
HumansAnimalsCells
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Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 2000 May 15; 14(10):1236-48.
Chen CY, Gherzi R, Andersen JS, Gaietta G, Jürchott K, Royer HD, Mann M, Karin M. PMID: 10817758; PMCID: PMC316620.
View in:
PubMed Mentions:
134 Fields:
Translation:
HumansCells
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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5243-8.
Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. PMID: 10805784; PMCID: PMC25813.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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NAK is an IkappaB kinase-activating kinase. Nature. 2000 Apr 13; 404(6779):778-82.
Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M. PMID: 10783893.
View in:
PubMed Mentions:
111 Fields:
Translation:
HumansAnimalsCells
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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr; 20(7):2334-42.
Cheng J, Yang J, Xia Y, Karin M, Su B. PMID: 10713157; PMCID: PMC85399.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 2000 Mar 01; 14(5):574-84.
Puri PL, Wu Z, Zhang P, Wood LD, Bhakta KS, Han J, Feramisco JR, Karin M, Wang JY. PMID: 10716945; PMCID: PMC316418.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansAnimalsCells
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The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol. 2000 Feb; 12(1):85-98.
Karin M, Delhase M. PMID: 10723801.
View in:
PubMed Mentions:
304 Fields:
Translation:
HumansAnimalsCells
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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 2000 Jan 06; 403(6765):103-8.
Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. PMID: 10638762.
View in:
PubMed Mentions:
309 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 2000; 18:621-63.
Karin M, Ben-Neriah Y. PMID: 10837071.
View in:
PubMed Mentions:
1480 Fields:
Translation:
HumansAnimalsCells
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Signaling pathways leading to nuclear factor-kappa B activation. Methods Enzymol. 2000; 319:273-9.
Li N, Karin M. PMID: 10907518.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Analysis and identification of protein-protein interactions using protein recruitment systems. Methods Enzymol. 2000; 328:47-59.
Aronheim A, Karin M. PMID: 11075337.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
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Assays for JNK and p38 mitogen-activated protein kinases. Methods Enzymol. 2000; 322:388-92.
Sudo T, Karin M. PMID: 10914034.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev. 1999 Dec; 89(1-2):115-24.
Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. PMID: 10559486.
View in:
PubMed Mentions:
121 Fields:
Translation:
Animals
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JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 1999 Dec; 11(6):721-31.
Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M. PMID: 10626894.
View in:
PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene. 1999 Nov 22; 18(49):6867-74.
Karin M. PMID: 10602462.
View in:
PubMed Mentions:
337 Fields:
Translation:
HumansAnimalsCells
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The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE. 1999 Oct 26; 1999(5):RE1.
Rothwarf DM, Karin M. PMID: 11865184.
View in:
PubMed Mentions:
167 Fields:
Translation:
HumansAnimalsCells
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Stress-induced JNK activation is independent of Gadd45 induction. J Biol Chem. 1999 Oct 15; 274(42):29595-8.
Shaulian E, Karin M. PMID: 10514425.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem. 1999 Sep 24; 274(39):27339-42.
Karin M. PMID: 10488062.
View in:
PubMed Mentions:
147 Fields:
Translation:
AnimalsCells
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Is NF-kappaB the sensor of oxidative stress? FASEB J. 1999 Jul; 13(10):1137-43.
Li N, Karin M. PMID: 10385605.
View in:
PubMed Mentions:
204 Fields:
Translation:
Humans
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Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol. 1999 Jul; 19(7):4547-51.
Zandi E, Karin M. PMID: 10373503; PMCID: PMC84252.
View in:
PubMed Mentions:
77 Fields:
Translation:
Humans
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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999 Jun 07; 189(11):1839-45.
Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. PMID: 10359587; PMCID: PMC2193082.
View in:
PubMed Mentions:
318 Fields:
Translation:
AnimalsCells
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Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). J Biol Chem. 1999 May 21; 274(21):15173-80.
Tian J, Karin M. PMID: 10329725.
View in:
PubMed Mentions:
33 Fields:
Translation:
Cells
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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 May 15; 13(10):1297-308.
Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M. PMID: 10346818; PMCID: PMC316725.
View in:
PubMed Mentions:
144 Fields:
Translation:
HumansCells
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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science. 1999 Apr 09; 284(5412):316-20.
Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. PMID: 10195896.
View in:
PubMed Mentions:
230 Fields:
Translation:
AnimalsCells
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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science. 1999 Apr 09; 284(5412):309-13.
Delhase M, Hayakawa M, Chen Y, Karin M. PMID: 10195894.
View in:
PubMed Mentions:
292 Fields:
Translation:
HumansCells
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Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 1999 Mar 01; 13(5):607-19.
Schreiber M, Kolbus A, Piu F, Szabowski A, Möhle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF. PMID: 10072388; PMCID: PMC316508.
View in:
PubMed Mentions:
214 Fields:
Translation:
AnimalsCells
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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol. 1999 Feb 11; 9(3):116-25.
Sabapathy K, Hu Y, Kallunki T, Schreiber M, David JP, Jochum W, Wagner EF, Karin M. PMID: 10021384.
View in:
PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J Exp Med. 1999 Jan 04; 189(1):145-58.
Hettmann T, DiDonato J, Karin M, Leiden JM. PMID: 9874571; PMCID: PMC1887697.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 1999 Jan; 19(1):751-63.
Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. PMID: 9858598; PMCID: PMC83932.
View in:
PubMed Mentions:
105 Fields:
Translation:
AnimalsCells
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The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation. Cold Spring Harb Symp Quant Biol. 1999; 64:491-503.
Delhase M, Karin M. PMID: 11232326.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 1998 Nov 01; 12(21):3369-81.
Xia Y, Wu Z, Su B, Murray B, Karin M. PMID: 9808624; PMCID: PMC317229.
View in:
PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13012-7.
Li N, Karin M. PMID: 9789032; PMCID: PMC23690.
View in:
PubMed Mentions:
117 Fields:
Translation:
HumansCells
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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998 Sep 17; 395(6699):297-300.
Rothwarf DM, Zandi E, Natoli G, Karin M. PMID: 9751060.
View in:
PubMed Mentions:
273 Fields:
Translation:
HumansCells
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Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28; 281(5381):1360-3.
Zandi E, Chen Y, Karin M. PMID: 9721103.
View in:
PubMed Mentions:
140 Fields:
Translation:
HumansAnimalsCells
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NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem. 1998 Aug 14; 273(33):21132-6.
Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. PMID: 9694868.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action? Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9067-9.
Karin M, Delhase M. PMID: 9689033; PMCID: PMC33875.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Multicellular stalk-like structures in Saccharomyces cerevisiae. J Bacteriol. 1998 Aug; 180(15):3992-6.
Engelberg D, Mimran A, Martinetto H, Otto J, Simchen G, Karin M, Fink GR. PMID: 9683500; PMCID: PMC107387.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci. 1998 Jul 15; 18(14):5124-35.
Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M. PMID: 9651196; PMCID: PMC6793486.
View in:
PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
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Mitogen-activated protein kinase cascades as regulators of stress responses. Ann N Y Acad Sci. 1998 Jun 30; 851:139-46.
Karin M. PMID: 9668616.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science. 1998 Jun 19; 280(5371):1945-9.
Chen CY, Del Gatto-Konczak F, Wu Z, Karin M. PMID: 9632395.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 1998 Jun 01; 17(11):3101-11.
Werlen G, Jacinto E, Xia Y, Karin M. PMID: 9606192; PMCID: PMC1170649.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansCells
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A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell. 1998 Jun; 9(6):1437-48.
Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D. PMID: 9614185; PMCID: PMC25366.
View in:
PubMed Mentions:
101 Fields:
Translation:
HumansAnimalsCells
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New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 1998 May 15; 93(4):487-90.
Karin M. PMID: 9604923.
View in:
PubMed Mentions:
64 Fields:
Translation:
Animals
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The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival. Cancer J Sci Am. 1998 May; 4 Suppl 1:S92-9.
Karin M. PMID: 9619277.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 1998 Jan; 8(1):31-41.
Jacinto E, Werlen G, Karin M. PMID: 9462509.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol Cell Biol. 1997 Dec; 17(12):7407-16.
Wu Z, Wu J, Jacinto E, Karin M. PMID: 9372971; PMCID: PMC232596.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta. 1997 Oct 24; 1333(2):F85-104.
Minden A, Karin M. PMID: 9395283.
View in:
PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997 Oct 17; 91(2):243-52.
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. PMID: 9346241.
View in:
PubMed Mentions:
495 Fields:
Translation:
HumansCells
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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997 Aug 07; 388(6642):548-54.
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. PMID: 9252186.
View in:
PubMed Mentions:
567 Fields:
Translation:
HumansCells
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Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol Cell Biol. 1997 Aug; 17(8):4687-95.
Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M. PMID: 9234725; PMCID: PMC232321.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102.
Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. PMID: 9154808; PMCID: PMC232162.
View in:
PubMed Mentions:
160 Fields:
Translation:
AnimalsCells
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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997 Apr 10; 336(15):1066-71.
Barnes PJ, Karin M. PMID: 9091804.
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PubMed Mentions:
1143 Fields:
Translation:
HumansCells
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AP-1 function and regulation. Curr Opin Cell Biol. 1997 Apr; 9(2):240-6.
Karin M, Liu Zg, Zandi E. PMID: 9069263.
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PubMed Mentions:
699 Fields:
Translation:
HumansAnimals
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Immunoregulatory genes and immunosuppression by glucocorticoids. Arch Toxicol Suppl. 1997; 19:87-95.
Auphan N, Didonato JA, Helmberg A, Rosette C, Karin M. PMID: 9079197.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996 Nov 29; 87(5):929-39.
Kallunki T, Deng T, Hibi M, Karin M. PMID: 8945519.
View in:
PubMed Mentions:
156 Fields:
Translation:
Cells
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A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev Biol. 1996 Nov 25; 180(1):353-64.
Reach M, Galindo RL, Towb P, Allen JL, Karin M, Wasserman SA. PMID: 8948598.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 1996 Nov 21; 384(6606):273-6.
Liu ZG, Baskaran R, Lea-Chou ET, Wood LD, Chen Y, Karin M, Wang JY. PMID: 8918879.
View in:
PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
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The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 1996 Nov 15; 15(22):6269-79.
Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M. PMID: 8947050; PMCID: PMC452450.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 1996 Nov 15; 274(5290):1194-7.
Rosette C, Karin M. PMID: 8895468.
View in:
PubMed Mentions:
198 Fields:
Translation:
HumansCells
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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. 1996 Nov 01; 87(3):565-76.
Liu ZG, Hsu H, Goeddel DV, Karin M. PMID: 8898208.
View in:
PubMed Mentions:
415 Fields:
Translation:
HumansCells
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The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996 Nov; 16(11):5947-54.
Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. PMID: 8887624; PMCID: PMC231597.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 1996 Oct 03; 383(6599):453-7.
Claret FX, Hibi M, Dhut S, Toda T, Karin M. PMID: 8837781.
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PubMed Mentions:
127 Fields:
Translation:
HumansAnimalsCells
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Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 2):S11-5.
Didonato JA, Saatcioglu F, Karin M. PMID: 8756781.
View in:
PubMed Mentions:
12 Fields:
Translation:
Humans
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Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. J Biol Chem. 1996 Jul 19; 271(29):17349-53.
Collins LR, Minden A, Karin M, Brown JH. PMID: 8663428.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol. 1996 Jun; 8(3):402-11.
Su B, Karin M. PMID: 8793994.
View in:
PubMed Mentions:
159 Fields:
Translation:
AnimalsCells
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Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol. 1996 Apr; 16(4):1295-304.
DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M. PMID: 8657102; PMCID: PMC231113.
View in:
PubMed Mentions:
198 Fields:
Translation:
HumansAnimalsCells
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The regulation of AP-1 activity by mitogen-activated protein kinases. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):127-34.
Karin M. PMID: 8650258.
View in:
PubMed Mentions:
75 Fields:
Translation:
Cells
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Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem. 1996 Feb 09; 271(6):3229-37.
Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI, Johnson GL. PMID: 8621725.
View in:
PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
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A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha. Mol Cell Biol. 1996 Jan; 16(1):219-27.
Claret FX, Antakly T, Karin M, Saatcioglu F. PMID: 8524299; PMCID: PMC230995.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. Mol Cell Biol. 1995 Dec; 15(12):6694-701.
Caelles C, Hennemann H, Karin M. PMID: 8524234; PMCID: PMC230922.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 1995 Dec 01; 14(23):5957-64.
Cavigelli M, Dolfi F, Claret FX, Karin M. PMID: 8846788; PMCID: PMC394715.
View in:
PubMed Mentions:
155 Fields:
Translation:
HumansCells
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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 1995 Oct 13; 270(5234):286-90.
Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. PMID: 7569976.
View in:
PubMed Mentions:
504 Fields:
Translation:
HumansAnimalsCells
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The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995 Jul 14; 270(28):16483-6.
Karin M. PMID: 7622446.
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PubMed Mentions:
596 Fields:
Translation:
HumansAnimalsCells
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Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol. 1995 Jul 01; 5(7):747-57.
Karin M, Hunter T. PMID: 7583121.
View in:
PubMed Mentions:
163 Fields:
Translation:
AnimalsCells
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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 1995 Jun 30; 81(7):1147-57.
Minden A, Lin A, Claret FX, Abo A, Karin M. PMID: 7600582.
View in:
PubMed Mentions:
394 Fields:
Translation:
HumansAnimalsCells
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Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4972-6.
Yoshioka K, Deng T, Cavigelli M, Karin M. PMID: 7761434; PMCID: PMC41829.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 1995 Apr 14; 268(5208):286-90.
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M. PMID: 7716521.
View in:
PubMed Mentions:
199 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B. Mol Cell Biol. 1995 Mar; 15(3):1302-11.
DiDonato JA, Mercurio F, Karin M. PMID: 7862124; PMCID: PMC230353.
View in:
PubMed Mentions:
92 Fields:
Translation:
HumansCells
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Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B. J Cell Biol. 1995 Mar; 128(6):1111-9.
Rosette C, Karin M. PMID: 7896875; PMCID: PMC2120413.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Multiple Ras functions can contribute to mammalian cell transformation. Cell. 1995 Feb 24; 80(4):533-41.
White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH. PMID: 7867061.
View in:
PubMed Mentions:
222 Fields:
Translation:
HumansAnimalsCells
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Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 1995 Feb 01; 14(3):452-60.
Helmberg A, Auphan N, Caelles C, Karin M. PMID: 7859735; PMCID: PMC398103.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 1994 Dec 15; 8(24):2996-3007.
Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. PMID: 8001819.
View in:
PubMed Mentions:
176 Fields:
Translation:
HumansCells
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Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A. EMBO J. 1994 Dec 15; 13(24):6006-10.
Smeal T, Hibi M, Karin M. PMID: 7813438; PMCID: PMC395577.
View in:
PubMed Mentions:
23 Fields:
Translation:
Cells
-
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science. 1994 Dec 09; 266(5191):1719-23.
Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M. PMID: 7992057.
View in:
PubMed Mentions:
263 Fields:
Translation:
HumansAnimalsCells
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Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J Biol Chem. 1994 Oct 21; 269(42):26396-401.
Westwick JK, Weitzel C, Minden A, Karin M, Brenner DA. PMID: 7929360.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
-
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol. 1994 Oct; 14(10):6683-8.
Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M. PMID: 7935387; PMCID: PMC359198.
View in:
PubMed Mentions:
112 Fields:
Translation:
HumansAnimalsCells
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Negative transcriptional regulation by nuclear receptors. Semin Cancer Biol. 1994 Oct; 5(5):347-59.
Saatcioglu F, Claret FX, Karin M. PMID: 7849263.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell. 1994 Sep 23; 78(6):949-61.
Aronheim A, Engelberg D, Li N, al-Alawi N, Schlessinger J, Karin M. PMID: 7923364.
View in:
PubMed Mentions:
130 Fields:
Translation:
HumansAnimalsCells
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c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature. 1994 Sep 08; 371(6493):171-5.
Deng T, Karin M. PMID: 8072547.
View in:
PubMed Mentions:
88 Fields:
Translation:
HumansCells
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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature. 1994 Jul 21; 370(6486):220-3.
Caelles C, Helmberg A, Karin M. PMID: 8028670.
View in:
PubMed Mentions:
190 Fields:
Translation:
Cells
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Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994 Jul 21; 370(6486):226-9.
Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. PMID: 8028671.
View in:
PubMed Mentions:
189 Fields:
Translation:
HumansAnimalsCells
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Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. DNA Cell Biol. 1994 Jul; 13(7):731-42.
Inouye C, Remondelli P, Karin M, Elledge S. PMID: 7772254.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor. Mol Cell Biol. 1994 Jul; 14(7):4929-37.
Engelberg D, Zandi E, Parker CS, Karin M. PMID: 8007989; PMCID: PMC358865.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6030-4.
Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. PMID: 8016110; PMCID: PMC44131.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 1994 Jun 03; 77(5):727-36.
Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. PMID: 8205621.
View in:
PubMed Mentions:
197 Fields:
Translation:
HumansAnimalsCells
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Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J Clin Invest. 1994 Jun; 93(6):2554-61.
Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M. PMID: 8200992; PMCID: PMC294481.
View in:
PubMed Mentions:
35 Fields:
Translation:
Cells
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Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr Opin Cell Biol. 1994 Jun; 6(3):415-24.
Karin M. PMID: 7917334.
View in:
PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
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BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins. Mol Cell Biol. 1994 Jun; 14(6):3915-26.
Zhang Q, Didonato JA, Karin M, McKeithan TW. PMID: 8196632; PMCID: PMC358758.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell. 1994 May 06; 77(3):381-90.
Engelberg D, Klein C, Martinetto H, Struhl K, Karin M. PMID: 8181058.
View in:
PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 1994 Mar 25; 76(6):1025-37.
Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. PMID: 8137421.
View in:
PubMed Mentions:
818 Fields:
Translation:
HumansCells
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A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation. Cell. 1993 Dec 17; 75(6):1095-105.
Saatcioglu F, Deng T, Karin M. PMID: 7903219.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Transcriptional control of GH expression and anterior pituitary development. Endocr Rev. 1993 Dec; 14(6):670-89.
Theill LE, Karin M. PMID: 8119232.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 1993 Nov; 7(11):2135-48.
Hibi M, Lin A, Smeal T, Minden A, Karin M. PMID: 8224842.
View in:
PubMed Mentions:
492 Fields:
Translation:
HumansAnimalsCells
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NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science. 1993 Sep 10; 261(5127):1442-5.
Devary Y, Rosette C, DiDonato JA, Karin M. PMID: 8367725.
View in:
PubMed Mentions:
125 Fields:
Translation:
HumansAnimalsCells
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Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature. 1993 Aug 05; 364(6437):544-7.
Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M, Chojkier M. PMID: 8336793.
View in:
PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
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A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Mol Cell Biol. 1993 Jun; 13(6):3675-85.
Saatcioglu F, Bartunek P, Deng T, Zenke M, Karin M. PMID: 8098843; PMCID: PMC359836.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev. 1993 Apr; 7(4):683-93.
Lew D, Brady H, Klausing K, Yaginuma K, Theill LE, Stauber C, Karin M, Mellon PL. PMID: 8096199.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev. 1993 Apr; 7(4):705-18.
Mercurio F, DiDonato JA, Rosette C, Karin M. PMID: 8458581.
View in:
PubMed Mentions:
110 Fields:
Translation:
HumansCells
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Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Mol Cell Biol. 1993 Apr; 13(4):2104-12.
Alberts AS, Deng T, Lin A, Meinkoth JL, Schönthal A, Mumby MC, Karin M, Feramisco JR. PMID: 8384305; PMCID: PMC359531.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev. 1993 Mar; 7(3):479-90.
Deng T, Karin M. PMID: 8383624.
View in:
PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones. Eur J Clin Pharmacol. 1993; 45 Suppl 1:S9-15; discussion S43-4.
Karin M, Yang-Yen HF, Chambard JC, Deng T, Saatcioglu F. PMID: 8313934.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Control of AP-1 activity by signal transduction cascades. Adv Second Messenger Phosphoprotein Res. 1993; 28:255-60.
Lin A, Smeal T, Binetruy B, Deng T, Chambard JC, Karin M. PMID: 8398411.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
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Regulation of human and yeast metallothionein gene transcription by heavy metal ions. Prog Clin Biol Res. 1993; 380:113-28.
Skroch P, Buchman C, Karin M. PMID: 8456121.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Promoter elements and transcriptional regulation of the acetylcholinesterase gene. DNA Cell Biol. 1993 Jan-Feb; 12(1):63-72.
Ekström TJ, Klump WM, Getman D, Karin M, Taylor P. PMID: 8422273.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Activation of activating protein 1 during hepatic acute phase response. Am J Physiol. 1993 Jan; 264(1 Pt 1):G95-103.
Hattori M, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. PMID: 8430810.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell. 1992 Dec 24; 71(7):1081-91.
Devary Y, Gottlieb RA, Smeal T, Karin M. PMID: 1473146.
View in:
PubMed Mentions:
157 Fields:
Translation:
HumansCells
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Control of transcription factors by signal transduction pathways: the beginning of the end. Trends Biochem Sci. 1992 Oct; 17(10):418-22.
Karin M, Smeal T. PMID: 1455510.
View in:
PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
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Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992 Oct; 12(10):4742-50.
Trejo J, Chambard JC, Karin M, Brown JH. PMID: 1328861; PMCID: PMC360401.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8572-6.
Deng T, Karin M. PMID: 1528863; PMCID: PMC49962.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
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Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell. 1992 Sep 04; 70(5):777-89.
Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M. PMID: 1516134.
View in:
PubMed Mentions:
112 Fields:
Translation:
Cells
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Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105. DNA Cell Biol. 1992 Sep; 11(7):523-37.
Mercurio F, Didonato J, Rosette C, Karin M. PMID: 1388725.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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The regulation of transcription by phosphorylation. Cell. 1992 Aug 07; 70(3):375-87.
Hunter T, Karin M. PMID: 1643656.
View in:
PubMed Mentions:
350 Fields:
Translation:
Cells
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Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol. 1992 Aug; 12(8):3507-13.
Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR, Karin M. PMID: 1630458; PMCID: PMC364600.
View in:
PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
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Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell. 1992 Jul 10; 70(1):105-13.
Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M. PMID: 1352481.
View in:
PubMed Mentions:
132 Fields:
Translation:
Cells
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Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J. 1992 Jun; 11(6):2261-9.
Theill LE, Hattori K, Lazzaro D, Castrillo JL, Karin M. PMID: 1600947; PMCID: PMC556693.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Signal transduction from cell surface to nucleus in development and disease. FASEB J. 1992 May; 6(8):2581-90.
Karin M. PMID: 1317309.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes Dev. 1992 Apr; 6(4):676-89.
Li L, Chambard JC, Karin M, Olson EN. PMID: 1313772.
View in:
PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
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Specific members of the Jun protein family regulate collagenase expression in response to various extracellular stimuli. Matrix Suppl. 1992; 1:156-64.
Angel P, Karin M. PMID: 1336108.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature. 1991 Dec 12; 354(6353):494-6.
Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. PMID: 1749429.
View in:
PubMed Mentions:
238 Fields:
Translation:
AnimalsCells
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The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1991 Dec 10; 1072(2-3):129-57.
Angel P, Karin M. PMID: 1751545.
View in:
PubMed Mentions:
835 Fields:
Translation:
HumansAnimalsCells
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The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol Cell Biol. 1991 Dec; 11(12):6286-95.
Alani R, Brown P, Binétruy B, Dosaka H, Rosenberg RK, Angel P, Karin M, Birrer MJ. PMID: 1944289; PMCID: PMC361817.
View in:
PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New Biol. 1991 Dec; 3(12):1206-19.
Yang-Yen HF, Zhang XK, Graupner G, Tzukerman M, Sakamoto B, Karin M, Pfahl M. PMID: 1667479.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
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The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box. Genes Dev. 1991 Aug; 5(8):1490-503.
McCormick A, Brady H, Fukushima J, Karin M. PMID: 1869051.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science. 1991 Jul 12; 253(5016):197-9.
Castrillo JL, Theill LE, Karin M. PMID: 1677216.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Signal transduction and gene control. Curr Opin Cell Biol. 1991 Jun; 3(3):467-73.
Karin M. PMID: 1832548.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature. 1991 May 09; 351(6322):122-7.
Binétruy B, Smeal T, Karin M. PMID: 1903181.
View in:
PubMed Mentions:
166 Fields:
Translation:
AnimalsCells
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Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol. 1991 May; 11(5):2804-11.
Devary Y, Gottlieb RA, Lau LF, Karin M. PMID: 1901948; PMCID: PMC360059.
View in:
PubMed Mentions:
140 Fields:
Translation:
HumansCells
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Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell. 1991 Feb 08; 64(3):573-84.
Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M, Hunter T. PMID: 1846781.
View in:
PubMed Mentions:
277 Fields:
Translation:
HumansCells
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Cell type specific expression of the growth hormone gene and its control by GHF-1. Nihon Naibunpi Gakkai Zasshi. 1990 Dec 20; 66(12):1205-20.
Karin M, Theill L, Castrillo JL, McCormick A, Brady H. PMID: 2292312.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Transcriptional control and the integration of cell-autonomous and environmental cues during development. Curr Opin Cell Biol. 1990 Dec; 2(6):996-1002.
Karin M. PMID: 2099815.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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A simplified method for the preparation of transcriptionally active liver nuclear extracts. DNA Cell Biol. 1990 Dec; 9(10):777-81.
Hattori M, Tugores A, Veloz L, Karin M, Brenner DA. PMID: 2264931.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Human metallothionein genes: structure of the functional locus at 16q13. Genomics. 1990 Nov; 8(3):513-8.
West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI. PMID: 2286373.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation. J Biol Chem. 1990 Oct 25; 265(30):18166-71.
William F, Wagner F, Karin M, Kraft AS. PMID: 2120223.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 1990 Sep 21; 62(6):1205-15.
Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M. PMID: 2169352.
View in:
PubMed Mentions:
354 Fields:
Translation:
HumansAnimalsCells
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A single amino acid change in CUP2 alters its mode of DNA binding. Mol Cell Biol. 1990 Sep; 10(9):4778-87.
Buchman C, Skroch P, Dixon W, Tullius TD, Karin M. PMID: 2167439; PMCID: PMC361081.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site. Mol Endocrinol. 1990 Jul; 4(7):973-80.
Lafyatis R, Kim SJ, Angel P, Roberts AB, Sporn MB, Karin M, Wilder RL. PMID: 2178224.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature. 1990 Jun 28; 345(6278):829-32.
McCormick A, Brady H, Theill LE, Karin M. PMID: 1972784.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter. New Biol. 1990 Jun; 2(6):566-73.
Radler-Pohl A, Pfeuffer I, Karin M, Serfling E. PMID: 2088505.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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DNA-binding activity of Jun is increased through its interaction with Fos. J Cell Biochem. 1990 Apr; 42(4):193-206.
Allegretto EA, Smeal T, Angel P, Spiegelman BM, Karin M. PMID: 2111328.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription. New Biol. 1990 Apr; 2(4):351-61.
Yang-Yen HF, Chiu R, Karin M. PMID: 1963081.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2710-4.
Kaina B, Lohrer H, Karin M, Herrlich P. PMID: 2320583; PMCID: PMC53760.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol. 1990 Apr; 10(4):1492-7.
Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB. PMID: 2108318; PMCID: PMC362252.
View in:
PubMed Mentions:
137 Fields:
Translation:
HumansCells
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Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell. 1990 Mar 09; 60(5):809-20.
Dollé P, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. PMID: 1690079.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Growth hormone gene regulation: a paradigm for cell-type-specific gene activation. Trends Genet. 1990 Mar; 6(3):92-6.
Karin M, Castrillo JL, Theill LE. PMID: 2183418.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Too many transcription factors: positive and negative interactions. New Biol. 1990 Feb; 2(2):126-31.
Karin M. PMID: 2128034.
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PubMed Mentions:
48 Fields:
Translation:
Cells
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Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regul. 1990 Feb; 1(3):269-78.
Kim SJ, Lafyatis R, Kim KY, Angel P, Fujiki H, Karin M, Sporn MB, Roberts AB. PMID: 1966042; PMCID: PMC361469.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1. Recent Prog Horm Res. 1990; 46:43-57; discussion 57-8.
Karin M, Theill L, Castrillo JL, McCormick A, Brady H. PMID: 2281188.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Adv Second Messenger Phosphoprotein Res. 1990; 24:352-8.
Leffert HL, Koch KS, Lu XP, Brenner DA, Karin M, Skelly HF, Rippe RA, Fey G, Chojkier M. PMID: 2169815.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell. 1989 Dec 22; 59(6):979-86.
Chiu R, Angel P, Karin M. PMID: 2513128.
View in:
PubMed Mentions:
156 Fields:
Translation:
HumansAnimalsCells
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Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev. 1989 Dec; 3(12B):2091-100.
Smeal T, Angel P, Meek J, Karin M. PMID: 2516828.
View in:
PubMed Mentions:
62 Fields:
Translation:
Cells
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Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature. 1989 Dec 21-28; 342(6252):945-8.
Theill LE, Castrillo JL, Wu D, Karin M. PMID: 2574416.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1. Science. 1989 Oct 13; 246(4927):249-51.
Muegge K, Williams TM, Kant J, Karin M, Chiu R, Schmidt A, Siebenlist U, Young HA, Durum SK. PMID: 2799385.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol. 1989 Oct; 1(1):35-43.
Angel P, Smeal T, Meek J, Karin M. PMID: 2518690.
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PubMed Mentions:
32 Fields:
Translation:
Cells
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The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Mol Cell Biol. 1989 Sep; 9(9):4091-5.
Buchman C, Skroch P, Welch J, Fogel S, Karin M. PMID: 2674688; PMCID: PMC362479.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element. Mol Endocrinol. 1989 May; 3(5):815-21.
Dana S, Karin M. PMID: 2547155.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner. EMBO J. 1989 May; 8(5):1455-60.
Mercurio F, Karin M. PMID: 2548845; PMCID: PMC400974.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. Oncogene. 1989 May; 4(5):629-36.
Schönthal A, Büscher M, Angel P, Rahmsdorf HJ, Ponta H, Hattori K, Chiu R, Karin M, Herrlich P. PMID: 2498806.
View in:
PubMed Mentions:
42 Fields:
Translation:
Cells
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Complexities of gene regulation by cAMP. Trends Genet. 1989 Mar; 5(3):65-7.
Karin M. PMID: 2544046.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 1989 Feb 16; 337(6208):661-3.
Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. PMID: 2537468.
View in:
PubMed Mentions:
194 Fields:
Translation:
HumansCells
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Purification of growth hormone-specific transcription factor GHF-1 containing homeobox. Science. 1989 Feb 10; 243(4892):814-7.
Castrillo JL, Bodner M, Karin M. PMID: 2563596.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J. 1989 Feb; 8(2):465-73.
Serfling E, Barthelmäs R, Pfeuffer I, Schenk B, Zarius S, Swoboda R, Mercurio F, Karin M. PMID: 2542017; PMCID: PMC400828.
View in:
PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. EMBO J. 1989 Jan; 8(1):255-60.
Welch J, Fogel S, Buchman C, Karin M. PMID: 2653812; PMCID: PMC400797.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain. EMBO J. 1988 Dec 20; 7(13):4245-53.
Haugen TH, Turek LP, Mercurio FM, Cripe TP, Olson BJ, Anderson RD, Seidl D, Karin M, Schiller J. PMID: 2854060; PMCID: PMC455138.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell. 1988 Dec 02; 55(5):875-85.
Angel P, Hattori K, Smeal T, Karin M. PMID: 3142689.
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PubMed Mentions:
396 Fields:
Translation:
HumansCells
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Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9148-52.
Hattori K, Angel P, Le Beau MM, Karin M. PMID: 3194415; PMCID: PMC282681.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell. 1988 Nov 04; 55(3):505-18.
Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. PMID: 2902927.
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PubMed Mentions:
141 Fields:
Translation:
AnimalsCells
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Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell. 1988 Oct 21; 55(2):379-89.
McCormick A, Wu D, Castrillo JL, Dana S, Strobl J, Thompson EB, Karin M. PMID: 3167985.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1. Genes Dev. 1988 Oct; 2(10):1216-26.
Hai TW, Liu F, Allegretto EA, Karin M, Green MR. PMID: 3144478.
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PubMed Mentions:
95 Fields:
Translation:
Humans
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Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene. 1988 Sep; 3(3):301-11.
Büscher M, Rahmsdorf HJ, Litfin M, Karin M, Herrlich P. PMID: 2849742.
View in:
PubMed Mentions:
75 Fields:
Translation:
HumansAnimalsCells
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The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell. 1988 Aug 12; 54(4):541-52.
Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M. PMID: 3135940.
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PubMed Mentions:
341 Fields:
Translation:
HumansCells
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Progesterone induction of metallothionein-IIA gene expression. Mol Endocrinol. 1988 Jun; 2(6):485-91.
Slater EP, Cato AC, Karin M, Baxter JD, Beato M. PMID: 2843758.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Cytosine methylation does not affect binding of transcription factor Sp1. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2066-70.
Harrington MA, Jones PA, Imagawa M, Karin M. PMID: 3281160; PMCID: PMC279929.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature. 1988 Mar 10; 332(6160):166-71.
Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M. PMID: 3347253.
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PubMed Mentions:
256 Fields:
Translation:
HumansCells
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Targets for signal-transducing protein kinases. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:131-42.
Hunter T, Angel P, Boyle WJ, Chiu R, Freed E, Gould KL, Isacke CM, Karin M, Lindberg RA, van der Geer P. PMID: 3076078.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter. EMBO J. 1987 Dec 20; 6(13):4067-71.
Dinter H, Chiu R, Imagawa M, Karin M, Jones KA. PMID: 3443102; PMCID: PMC553889.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell. 1987 Oct 23; 51(2):251-60.
Imagawa M, Chiu R, Karin M. PMID: 2822255.
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PubMed Mentions:
309 Fields:
Translation:
HumansAnimalsCells
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Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature. 1987 Oct 15-21; 329(6140):648-51.
Chiu R, Imagawa M, Imbra RJ, Bockoven JR, Karin M. PMID: 2821407.
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PubMed Mentions:
104 Fields:
Translation:
HumansCells
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A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell. 1987 Jul 17; 50(2):267-75.
Bodner M, Karin M. PMID: 3594572.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 1987 Jun 19; 49(6):729-39.
Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M. PMID: 3034432.
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PubMed Mentions:
838 Fields:
Translation:
HumansAnimalsCells
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Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome. J Clin Invest. 1987 May; 79(5):1338-42.
Packman S, Palmiter RD, Karin M, O'Toole C. PMID: 3571489; PMCID: PMC424381.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J. 1987 Apr; 6(4):971-81.
Lefevre C, Imagawa M, Dana S, Grindlay J, Bodner M, Karin M. PMID: 3595566; PMCID: PMC553491.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Metallothionein gene expression is regulated by serum factors and activators of protein kinase C. Mol Cell Biol. 1987 Apr; 7(4):1358-63.
Imbra RJ, Karin M. PMID: 3600629; PMCID: PMC365221.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity. Mol Cell Biol. 1987 Feb; 7(2):606-13.
Karin M, Haslinger A, Heguy A, Dietlin T, Cooke T. PMID: 3821726; PMCID: PMC365115.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature. 1987 Jan 22-28; 325(6102):368-72.
Lee W, Haslinger A, Karin M, Tjian R. PMID: 3027570.
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PubMed Mentions:
243 Fields:
Translation:
HumansCells
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Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J. 1987 Jan; 6(1):145-52.
Haugen TH, Cripe TP, Ginder GD, Karin M, Turek LP. PMID: 3034572; PMCID: PMC553370.
View in:
PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Transcriptional control mechanisms which regulate the expression of human metallothionein genes. Experientia Suppl. 1987; 52:401-5.
Karin M, Haslinger A, Heguy A, Dietlin T, Imbra R. PMID: 2959529.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature. 1986 Oct 9-15; 323(6088):555-8.
Imbra RJ, Karin M. PMID: 3020435.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells
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Structure and tissue-specific expression of the human metallothionein IB gene. Mol Cell Biol. 1986 Jun; 6(6):2149-57.
Heguy A, West A, Richards RI, Karin M. PMID: 3785191; PMCID: PMC367755.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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In vivo competition between a metallothionein regulatory element and the SV40 enhancer. Science. 1986 Apr 04; 232(4746):76-80.
Scholer H, Haslinger A, Heguy A, Holtgreve H, Karin M. PMID: 3006253.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8572-6.
Haslinger A, Karin M. PMID: 3866241; PMCID: PMC390959.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene. Mol Cell Biol. 1985 Nov; 5(11):2984-92.
Slater EP, Rabenau O, Karin M, Baxter JD, Beato M. PMID: 3018491; PMCID: PMC369110.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Interleukin 1 regulates human metallothionein gene expression. Mol Cell Biol. 1985 Oct; 5(10):2866-9.
Karin M, Imbra RJ, Heguy A, Wong G. PMID: 3879767; PMCID: PMC367029.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Metallothioneins: proteins in search of function. Cell. 1985 May; 41(1):9-10.
Karin M. PMID: 2581697.
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PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
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Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. Nature. 1985 Feb 21-27; 313(6004):709-11.
Le Beau MM, Diaz MO, Karin M, Rowley JD. PMID: 3856101.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor. Trans Assoc Am Physicians. 1985; 98:66-73.
Slater EP, Anderson TR, Cattini PA, Eberhardt NL, Karin M, Mellon PL, Baxter JD. PMID: 3842208.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes. DNA. 1984 Aug; 3(4):319-26.
Karin M, Holtgreve H. PMID: 6489094.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Cell. 1984 May; 37(1):263-72.
Richards RI, Heguy A, Karin M. PMID: 6327055.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature. 1984 Apr 5-11; 308(5959):513-9.
Karin M, Haslinger A, Holtgreve H, Richards RI, Krauter P, Westphal HM, Beato M. PMID: 6323998.
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PubMed Mentions:
237 Fields:
Translation:
HumansCells
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The human metallothionein gene family: structure and expression. Environ Health Perspect. 1984 Mar; 54:111-5.
Karin M, Richards RI. PMID: 6734550; PMCID: PMC1568162.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA. Cell. 1984 Feb; 36(2):371-9.
Karin M, Haslinger A, Holtgreve H, Cathala G, Slater E, Baxter JD. PMID: 6692472.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):337-41.
Karin M, Najarian R, Haslinger A, Valenzuela P, Welch J, Fogel S. PMID: 6364141; PMCID: PMC344671.
View in:
PubMed Mentions:
104 Fields:
Translation:
AnimalsCells
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Mechanisms of glucocorticoid hormone action. J Steroid Biochem. 1984 Jan; 20(1):77-88.
Lan NC, Karin M, Nguyen T, Weisz A, Birnbaum MJ, Eberhardt NL, Baxter JD. PMID: 6368989.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells. DNA. 1984; 3(2):147-55.
Karin M, Eberhardt NL, Mellon SH, Malich N, Richards RI, Slater EP, Barta A, Martial JA, Baxter JD, Cathala G. PMID: 6723496.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Gene amplification in yeast: CUP1 copy number regulates copper resistance. Curr Genet. 1983 Sep; 7(5):347-55.
Fogel S, Welch JW, Cathala G, Karin M. PMID: 24173415.
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PubMed Mentions:
28 Fields:
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Industrial yeasts display tandem gene iteration at the CUP1 region. Mol Cell Biol. 1983 Aug; 3(8):1353-61.
Welch JW, Fogel S, Cathala G, Karin M. PMID: 6621529; PMCID: PMC369981.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4040-4.
Karin M, Cathala G, Nguyen-Huu MC. PMID: 6306660; PMCID: PMC394196.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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A method for isolation of intact, translationally active ribonucleic acid. DNA. 1983; 2(4):329-35.
Cathala G, Savouret JF, Mendez B, West BL, Karin M, Martial JA, Baxter JD. PMID: 6198133.
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PubMed Mentions:
395 Fields:
Translation:
Cells
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Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. Nature. 1982 Oct 28; 299(5886):797-802.
Karin M, Richards RI. PMID: 7133118.
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PubMed Mentions:
151 Fields:
Translation:
HumansCells
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Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. Nucleic Acids Res. 1982 May 25; 10(10):3165-73.
Karin M, Richards RI. PMID: 6896577; PMCID: PMC320698.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals. Eur J Biochem. 1981 Sep 01; 118(3):527-31.
Karin M, Andersen RD, Herschman HR. PMID: 7297561.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids. J Cell Physiol. 1981 Jan; 106(1):63-74.
Karin M, Slater EP, Herschman HR. PMID: 6162854.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Induction of metallothionein in HeLa cells by dexamethasone and zinc. Eur J Biochem. 1981 Jan; 113(2):267-72.
Karin M, Herschman HR. PMID: 7202410.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response. Nature. 1980 Jul 17; 286(5770):295-7.
Karin M, Andersen RD, Slater E, Smith K, Herschman HR. PMID: 7402316.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc. Eur J Biochem. 1980 Jun; 107(2):395-401.
Karin M, Herschman HR. PMID: 7398649.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells. J Cell Physiol. 1980 Apr; 103(1):35-40.
Karin M, Herschman HR. PMID: 7430258.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Primary induction of metallothionein by dexamethasone in culture rat hepatocytes. Biochem Biophys Res Commun. 1980 Feb 12; 92(3):1052-69.
Karin M, Herschman HR, Weinstein D. PMID: 7362599.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures. Science. 1979 Apr 13; 204(4389):176-7.
Karin M, Herschman HR. PMID: 432639.
View in:
PubMed Mentions:
31 Fields:
Translation:
Cells